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94 results on '"Riby, Jacques"'

51. A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Author

Infection & Immunity, dIRAS RA-I&I RA, Risk Assessment, LS IRAS EEPI GRA (Gezh.risico-analyse), Vijai, Joseph, Wang, Zhaoming, Berndt, Sonja I, Skibola, Christine F, Slager, Susan L, de Sanjose, Silvia, Melbye, Mads, Glimelius, Bengt, Bracci, Paige M, Conde, Lucia, Birmann, Brenda M, Wang, Sophia S, Brooks-Wilson, Angela R, Lan, Qing, de Bakker, Paul I W, Vermeulen, Roel C H, Portlock, Carol, Ansell, Stephen M, Link, Brian K, Riby, Jacques, North, Kari E, Gu, Jian, Hjalgrim, Henrik, Cozen, Wendy, Becker, Nikolaus, Teras, Lauren R, Spinelli, John J, Turner, Jenny, Zhang, Yawei, Purdue, Mark P, Giles, Graham G, Kelly, Rachel S, Zeleniuch-Jacquotte, Anne, Ennas, Maria Grazia, Monnereau, Alain, Bertrand, Kimberly A, Albanes, Demetrius, Lightfoot, Tracy, Yeager, Meredith, Chung, Charles C, Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Villano, Danylo J, Maria, Ann, Corines, Marina, Thomas, Tinu, Novak, Anne J, Dogan, Ahmet, Liebow, Mark, Thompson, Carrie A, Witzig, Thomas E, Habermann, Thomas M, Weiner, George J, Smith, Martyn T, Holly, Elizabeth A, Jackson, Rebecca D, Tinker, Lesley F, Ye, Yuanqing, Adami, Hans-Olov, Smedby, Karin E, De Roos, Anneclaire J, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Diver, W Ryan, Vajdic, Claire M, Armstrong, Bruce K, Kricker, Anne, Zheng, Tongzhang, Holford, Theodore R, Severi, Gianluca, Vineis, Paolo, Ferri, Giovanni M, Ricco, Rosalia, Miligi, Lucia, Clavel, Jacqueline, Giovannucci, Edward, Kraft, Peter, Virtamo, Jarmo, Smith, Alex, Kane, Eleanor, Roman, Eve, Chiu, Brian C H, Fraumeni, Joseph F, Wu, Xifeng, Cerhan, James R, Offit, Kenneth, Chanock, Stephen J, Rothman, Nathaniel, Nieters, Alexandra, Infection & Immunity, dIRAS RA-I&I RA, Risk Assessment, LS IRAS EEPI GRA (Gezh.risico-analyse), Vijai, Joseph, Wang, Zhaoming, Berndt, Sonja I, Skibola, Christine F, Slager, Susan L, de Sanjose, Silvia, Melbye, Mads, Glimelius, Bengt, Bracci, Paige M, Conde, Lucia, Birmann, Brenda M, Wang, Sophia S, Brooks-Wilson, Angela R, Lan, Qing, de Bakker, Paul I W, Vermeulen, Roel C H, Portlock, Carol, Ansell, Stephen M, Link, Brian K, Riby, Jacques, North, Kari E, Gu, Jian, Hjalgrim, Henrik, Cozen, Wendy, Becker, Nikolaus, Teras, Lauren R, Spinelli, John J, Turner, Jenny, Zhang, Yawei, Purdue, Mark P, Giles, Graham G, Kelly, Rachel S, Zeleniuch-Jacquotte, Anne, Ennas, Maria Grazia, Monnereau, Alain, Bertrand, Kimberly A, Albanes, Demetrius, Lightfoot, Tracy, Yeager, Meredith, Chung, Charles C, Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Villano, Danylo J, Maria, Ann, Corines, Marina, Thomas, Tinu, Novak, Anne J, Dogan, Ahmet, Liebow, Mark, Thompson, Carrie A, Witzig, Thomas E, Habermann, Thomas M, Weiner, George J, Smith, Martyn T, Holly, Elizabeth A, Jackson, Rebecca D, Tinker, Lesley F, Ye, Yuanqing, Adami, Hans-Olov, Smedby, Karin E, De Roos, Anneclaire J, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Diver, W Ryan, Vajdic, Claire M, Armstrong, Bruce K, Kricker, Anne, Zheng, Tongzhang, Holford, Theodore R, Severi, Gianluca, Vineis, Paolo, Ferri, Giovanni M, Ricco, Rosalia, Miligi, Lucia, Clavel, Jacqueline, Giovannucci, Edward, Kraft, Peter, Virtamo, Jarmo, Smith, Alex, Kane, Eleanor, Roman, Eve, Chiu, Brian C H, Fraumeni, Joseph F, Wu, Xifeng, Cerhan, James R, Offit, Kenneth, Chanock, Stephen J, Rothman, Nathaniel, and Nieters, Alexandra

Published
2015

52. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, Chatterjee, Nilanjan, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, and Chatterjee, Nilanjan

Published
2015

53. PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

Author

Nieters, Alexandra, Conde, Lucia, Slager, Susan L., Brooks-Wilson, Angela, Morton, Lindsay, Skibola, Danica R., Novak, Anne J., Riby, Jacques, Ansell, Stephen M., Halperin, Eran, Shanafelt, Tait D., Agana, Luz, Wang, Alice H., De Roos, Anneclaire J., Severson, Richard K., Cozen, Wendy, Spinelli, John, Butterbach, Katja, Becker, Nikolaus, de Sanjose, Silvia, Benavente, Yolanda, Cocco, Pierluigi, Staines, Anthony, Maynadié, Marc, Foretova, Lenka, Boffetta, Paolo, Brennan, Paul, Lan, Qing, Zhang, Yawei, Zheng, Tongzhang, Purdue, Mark, Armstrong, Bruce, Kricker, Anne, Vajdic, Claire M., Grulich, Andrew, Smith, Martyn T., Bracci, Paige M., Chanock, Stephen J., Hartge, Patricia, Cerhan, James R., Wang, Sophia S., Rothman, Nathaniel, and Skibola, Christine F.

Published
2012
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54. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia

Author

Slager, Susan L., Skibola, Christine F., Di Bernardo, Maria Chiara, Conde, Lucia, Broderick, Peter, McDonnell, Shannon K., Goldin, Lynn R., Croft, Naomi, Holroyd, Amy, Harris, Shelley, Riby, Jacques, Serie, Daniel J., Kay, Neil E., Call, Timothy G., Bracci, Paige M., Halperin, Eran, Lanasa, Mark C., Cunningham, Julie M., Leis, Jose F., Morrison, Vicki A., Spector, Logan G., Vachon, Celine M., Shanafelt, Tait D., Strom, Sara S., Camp, Nicola J., Weinberg, J. Brice, Matutes, Estella, Caporaso, Neil E., Wade, Rachel, Dyer, Martin J.S., Dearden, Claire, Cerhan, James R., Catovsky, Daniel, and Houlston, Richard S.

Published
2012
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55. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Sampson, Joshua N., primary, Wheeler, William A., additional, Yeager, Meredith, additional, Panagiotou, Orestis, additional, Wang, Zhaoming, additional, Berndt, Sonja I., additional, Lan, Qing, additional, Abnet, Christian C., additional, Amundadottir, Laufey T., additional, Figueroa, Jonine D., additional, Landi, Maria Teresa, additional, Mirabello, Lisa, additional, Savage, Sharon A., additional, Taylor, Philip R., additional, Vivo, Immaculata De, additional, McGlynn, Katherine A., additional, Purdue, Mark P., additional, Rajaraman, Preetha, additional, Adami, Hans-Olov, additional, Ahlbom, Anders, additional, Albanes, Demetrius, additional, Amary, Maria Fernanda, additional, An, She-Juan, additional, Andersson, Ulrika, additional, Andriole, Gerald, additional, Andrulis, Irene L., additional, Angelucci, Emanuele, additional, Ansell, Stephen M., additional, Arici, Cecilia, additional, Armstrong, Bruce K., additional, Arslan, Alan A., additional, Austin, Melissa A., additional, Baris, Dalsu, additional, Barkauskas, Donald A., additional, Bassig, Bryan A., additional, Becker, Nikolaus, additional, Benavente, Yolanda, additional, Benhamou, Simone, additional, Berg, Christine, additional, Van Den Berg, David, additional, Bernstein, Leslie, additional, Bertrand, Kimberly A., additional, Birmann, Brenda M., additional, Black, Amanda, additional, Boeing, Heiner, additional, Boffetta, Paolo, additional, Boutron-Ruault, Marie-Christine, additional, Bracci, Paige M., additional, Brinton, Louise, additional, Brooks-Wilson, Angela R., additional, Bueno-de-Mesquita, H. Bas, additional, Burdett, Laurie, additional, Buring, Julie, additional, Butler, Mary Ann, additional, Cai, Qiuyin, additional, Cancel-Tassin, Geraldine, additional, Canzian, Federico, additional, Carrato, Alfredo, additional, Carreon, Tania, additional, Carta, Angela, additional, Chan, John K. C., additional, Chang, Ellen T., additional, Chang, Gee-Chen, additional, Chang, I-Shou, additional, Chang, Jiang, additional, Chang-Claude, Jenny, additional, Chen, Chien-Jen, additional, Chen, Chih-Yi, additional, Chen, Chu, additional, Chen, Chung-Hsing, additional, Chen, Constance, additional, Chen, Hongyan, additional, Chen, Kexin, additional, Chen, Kuan-Yu, additional, Chen, Kun-Chieh, additional, Chen, Ying, additional, Chen, Ying-Hsiang, additional, Chen, Yi-Song, additional, Chen, Yuh-Min, additional, Chien, Li-Hsin, additional, Chirlaque, María-Dolores, additional, Choi, Jin Eun, additional, Choi, Yi Young, additional, Chow, Wong-Ho, additional, Chung, Charles C., additional, Clavel, Jacqueline, additional, Clavel-Chapelon, Françoise, additional, Cocco, Pierluigi, additional, Colt, Joanne S., additional, Comperat, Eva, additional, Conde, Lucia, additional, Connors, Joseph M., additional, Conti, David, additional, Cortessis, Victoria K., additional, Cotterchio, Michelle, additional, Cozen, Wendy, additional, Crouch, Simon, additional, Crous-Bou, Marta, additional, Cussenot, Olivier, additional, Davis, Faith G., additional, Ding, Ti, additional, Diver, W. Ryan, additional, Dorronsoro, Miren, additional, Dossus, Laure, additional, Duell, Eric J., additional, Ennas, Maria Grazia, additional, Erickson, Ralph L., additional, Feychting, Maria, additional, Flanagan, Adrienne M., additional, Foretova, Lenka, additional, Fraumeni, Joseph F., additional, Freedman, Neal D., additional, Beane Freeman, Laura E., additional, Fuchs, Charles, additional, Gago-Dominguez, Manuela, additional, Gallinger, Steven, additional, Gao, Yu-Tang, additional, Gapstur, Susan M., additional, Garcia-Closas, Montserrat, additional, García-Closas, Reina, additional, Gascoyne, Randy D., additional, Gastier-Foster, Julie, additional, Gaudet, Mia M., additional, Gaziano, J. Michael, additional, Giffen, Carol, additional, Giles, Graham G., additional, Giovannucci, Edward, additional, Glimelius, Bengt, additional, Goggins, Michael, additional, Gokgoz, Nalan, additional, Goldstein, Alisa M., additional, Gorlick, Richard, additional, Gross, Myron, additional, Grubb, Robert, additional, Gu, Jian, additional, Guan, Peng, additional, Gunter, Marc, additional, Guo, Huan, additional, Habermann, Thomas M., additional, Haiman, Christopher A., additional, Halai, Dina, additional, Hallmans, Goran, additional, Hassan, Manal, additional, Hattinger, Claudia, additional, He, Qincheng, additional, He, Xingzhou, additional, Helzlsouer, Kathy, additional, Henderson, Brian, additional, Henriksson, Roger, additional, Hjalgrim, Henrik, additional, Hoffman-Bolton, Judith, additional, Hohensee, Chancellor, additional, Holford, Theodore R., additional, Holly, Elizabeth A., additional, Hong, Yun-Chul, additional, Hoover, Robert N., additional, Horn-Ross, Pamela L., additional, Hosain, G. 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M., additional, Perng, Reury-Perng, additional, Peters, Ulrike, additional, Petersen, Gloria M., additional, Picci, Piero, additional, Pike, Malcolm C., additional, Porru, Stefano, additional, Prescott, Jennifer, additional, Prokunina-Olsson, Ludmila, additional, Qian, Biyun, additional, Qiao, You-Lin, additional, Rais, Marco, additional, Riboli, Elio, additional, Riby, Jacques, additional, Risch, Harvey A., additional, Rizzato, Cosmeri, additional, Rodabough, Rebecca, additional, Roman, Eve, additional, Roupret, Morgan, additional, Ruder, Avima M., additional, Sanjose, Silvia de, additional, Scelo, Ghislaine, additional, Schned, Alan, additional, Schumacher, Fredrick, additional, Schwartz, Kendra, additional, Schwenn, Molly, additional, Scotlandi, Katia, additional, Seow, Adeline, additional, Serra, Consol, additional, Serra, Massimo, additional, Sesso, Howard D., additional, Setiawan, Veronica Wendy, additional, Severi, Gianluca, additional, Severson, Richard K., additional, Shanafelt, Tait D., additional, Shen, Hongbing, additional, Shen, Wei, additional, Shin, Min-Ho, additional, Shiraishi, Kouya, additional, Shu, Xiao-Ou, additional, Siddiq, Afshan, additional, Sierrasesúmaga, Luis, additional, Sihoe, Alan Dart Loon, additional, Skibola, Christine F., additional, Smith, Alex, additional, Smith, Martyn T., additional, Southey, Melissa C., additional, Spinelli, John J., additional, Staines, Anthony, additional, Stampfer, Meir, additional, Stern, Marianna C., additional, Stevens, Victoria L., additional, Stolzenberg-Solomon, Rachael S., additional, Su, Jian, additional, Su, Wu-Chou, additional, Sund, Malin, additional, Sung, Jae Sook, additional, Sung, Sook Whan, additional, Tan, Wen, additional, Tang, Wei, additional, Tardón, Adonina, additional, Thomas, David, additional, Thompson, Carrie A., additional, Tinker, Lesley F., additional, Tirabosco, Roberto, additional, Tjønneland, Anne, additional, Travis, Ruth C., additional, Trichopoulos, Dimitrios, additional, Tsai, Fang-Yu, additional, Tsai, Ying-Huang, additional, Tucker, Margaret, additional, Turner, Jenny, additional, Vajdic, Claire M., additional, Vermeulen, Roel C. H., additional, Villano, Danylo J., additional, Vineis, Paolo, additional, Virtamo, Jarmo, additional, Visvanathan, Kala, additional, Wactawski-Wende, Jean, additional, Wang, Chaoyu, additional, Wang, Chih-Liang, additional, Wang, Jiu-Cun, additional, Wang, Junwen, additional, Wei, Fusheng, additional, Weiderpass, Elisabete, additional, Weiner, George J., additional, Weinstein, Stephanie, additional, Wentzensen, Nicolas, additional, White, Emily, additional, Witzig, Thomas E., additional, Wolpin, Brian M., additional, Wong, Maria Pik, additional, Wu, Chen, additional, Wu, Guoping, additional, Wu, Junjie, additional, Wu, Tangchun, additional, Wu, Wei, additional, Wu, Xifeng, additional, Wu, Yi-Long, additional, Wunder, Jay S., additional, Xiang, Yong-Bing, additional, Xu, Jun, additional, Xu, Ping, additional, Yang, Pan-Chyr, additional, Yang, Tsung-Ying, additional, Ye, Yuanqing, additional, Yin, Zhihua, additional, Yokota, Jun, additional, Yoon, Ho-Il, additional, Yu, Chong-Jen, additional, Yu, Herbert, additional, Yu, Kai, additional, Yuan, Jian-Min, additional, Zelenetz, Andrew, additional, Zeleniuch-Jacquotte, Anne, additional, Zhang, Xu-Chao, additional, Zhang, Yawei, additional, Zhao, Xueying, additional, Zhao, Zhenhong, additional, Zheng, Hong, additional, Zheng, Tongzhang, additional, Zheng, Wei, additional, Zhou, Baosen, additional, Zhu, Meng, additional, Zucca, Mariagrazia, additional, Boca, Simina M., additional, Cerhan, James R., additional, Ferri, Giovanni M., additional, Hartge, Patricia, additional, Hsiung, Chao Agnes, additional, Magnani, Corrado, additional, Miligi, Lucia, additional, Morton, Lindsay M., additional, Smedby, Karin E., additional, Teras, Lauren R., additional, Vijai, Joseph, additional, Wang, Sophia S., additional, Brennan, Paul, additional, Caporaso, Neil E., additional, Hunter, David J., additional, Kraft, Peter, additional, Rothman, Nathaniel, additional, Silverman, Debra T., additional, Slager, Susan L., additional, Chanock, Stephen J., additional, and Chatterjee, Nilanjan, additional

Published
2015
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56. A Sandwich ELISA for Adducts of Polycyclic Aromatic Hydrocarbons with Human Serum Albumin1

Author

Chung, Ming Kei, Riby, Jacques, Li, He, Iavarone, Anthony T., Williams, Evan R., Zheng, Yuxin, and Rappaport, Stephen M.

Subjects
Pyrenes, Antibodies, Monoclonal, Enzyme-Linked Immunosorbent Assay, Air Pollutants, Occupational, DNA, Article, Mass Spectrometry, body regions, DNA Adducts, Occupational Exposure, embryonic structures, polycyclic compounds, Humans, Polycyclic Aromatic Hydrocarbons, Biomarkers, Serum Albumin
Abstract

Adducts of benzo[a]pyrene-diolepoxide (BPDE) with blood nucleophiles have been used as biomarkers of exposure to polycyclic aromatic hydrocarbons (PAHs). The most popular such assay is a competitive enzyme-linked immunosorbent assay (ELISA) that employs monoclonal antibody 8E11 to detect benzo[a]pyrene tetrols following hydrolysis of BPDE adducts from lymphocyte DNA or human serum albumin (HSA). Here we used 8E11 as the capture antibody in a sandwich ELISA to detect BPDE-HSA adducts directly in 1-mg samples of HSA or 20 microl of serum/plasma. The assay employs an anti-HSA antibody for detection, and this is amplified by an avidin/biotinylated horseradish peroxidase complex. The sandwich ELISA has advantages of specificity and simplicity and is approximately 10 times more sensitive than the competitive ELISA. To validate the assay, HSA samples were assayed from three populations with known high PAH exposures (coke oven workers), medium PAH exposures (steel factory control workers), and low PAH exposures (volunteer subjects) (n=30). The respective geometric mean levels of BPDE-HSA adducts--67.8, 14.7, and 1.93 ng/mg HSA (1010, 220, and 28.9 fmol BPDE equiv/mg HSA)--were significantly different (P0.05). The sandwich ELISA will be useful for screening PAH exposures in large epidemiologic studies and can be extended to other adducts for which capture antibodies are available.

Published
2010

57. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Cerhan, James R., Berndt, Sonja I., Vijai, Joseph, Ghesquières, Hervé, McKay, James, Wang, Sophia S., Wang, Zhaoming, Yeager, Meredith, Conde, Lucia, De Bakker, Paul I W, Nieters, Alexandra, Cox, David, Burdett, Laurie, Monnereau, Alain, Flowers, Christopher R., De Roos, Anneclaire J., Brooks-Wilson, Angela R., Lan, Qing, Severi, Gianluca, Melbye, Mads, Gu, Jian, Jackson, Rebecca D., Kane, Eleanor, Teras, Lauren R., Purdue, Mark P., Vajdic, Claire M., Spinelli, John J., Giles, Graham G., Albanes, Demetrius, Kelly, Rachel S., Zucca, Mariagrazia, Bertrand, Kimberly A., Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Hutchinson, Amy, Zhi, Degui, Habermann, Thomas M., Link, Brian K., Novak, Anne J., Dogan, Ahmet, Asmann, Yan W., Liebow, Mark, Thompson, Carrie A., Ansell, Stephen M., Witzig, Thomas E., Weiner, George J., Veron, Amelie S., Zelenika, Diana, Tilly, Hervé, Haioun, Corinne, Molina, Thierry Jo, Hjalgrim, Henrik, Glimelius, Bengt, Adami, Hans Olov, Bracci, Paige M., Riby, Jacques, Smith, Martyn T., Holly, Elizabeth A., Cozen, Wendy, Hartge, Patricia, Morton, Lindsay M., Severson, Richard K., Tinker, Lesley F., North, Kari E., Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, Lightfoot, Tracy, Crouch, Simon, Smith, Alex, Roman, Eve, Diver, W. Ryan, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J., Villano, Danylo J., Zheng, Tongzhang, Zhang, Yawei, Holford, Theodore R., Kricker, Anne, Turner, Jenny, Southey, Melissa C., Clavel, Jacqueline, Virtamo, Jarmo, Weinstein, Stephanie, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Vermeulen, Roel C H, Boeing, Heiner, Tjonneland, Anne, Angelucci, Emanuele, Di Lollo, Simonetta, Rais, Marco, Birmann, Brenda M., Laden, Francine, Giovannucci, Edward, Kraft, Peter, Huang, Jinyan, Ma, Baoshan, Ye, Yuanqing, Chiu, Brian C H, Sampson, Joshua, Liang, Liming, Park, Ju Hyun, Chung, Charles C., Weisenburger, Dennis D., Chatterjee, Nilanjan, Fraumeni, Joseph F., Slager, Susan L., Wu, Xifeng, De Sanjose, Silvia, Smedby, Karin E., Salles, Gilles, Skibola, Christine F., Rothman, Nathaniel, Chanock, Stephen J., LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Cerhan, James R., Berndt, Sonja I., Vijai, Joseph, Ghesquières, Hervé, McKay, James, Wang, Sophia S., Wang, Zhaoming, Yeager, Meredith, Conde, Lucia, De Bakker, Paul I W, Nieters, Alexandra, Cox, David, Burdett, Laurie, Monnereau, Alain, Flowers, Christopher R., De Roos, Anneclaire J., Brooks-Wilson, Angela R., Lan, Qing, Severi, Gianluca, Melbye, Mads, Gu, Jian, Jackson, Rebecca D., Kane, Eleanor, Teras, Lauren R., Purdue, Mark P., Vajdic, Claire M., Spinelli, John J., Giles, Graham G., Albanes, Demetrius, Kelly, Rachel S., Zucca, Mariagrazia, Bertrand, Kimberly A., Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Hutchinson, Amy, Zhi, Degui, Habermann, Thomas M., Link, Brian K., Novak, Anne J., Dogan, Ahmet, Asmann, Yan W., Liebow, Mark, Thompson, Carrie A., Ansell, Stephen M., Witzig, Thomas E., Weiner, George J., Veron, Amelie S., Zelenika, Diana, Tilly, Hervé, Haioun, Corinne, Molina, Thierry Jo, Hjalgrim, Henrik, Glimelius, Bengt, Adami, Hans Olov, Bracci, Paige M., Riby, Jacques, Smith, Martyn T., Holly, Elizabeth A., Cozen, Wendy, Hartge, Patricia, Morton, Lindsay M., Severson, Richard K., Tinker, Lesley F., North, Kari E., Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, Lightfoot, Tracy, Crouch, Simon, Smith, Alex, Roman, Eve, Diver, W. Ryan, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J., Villano, Danylo J., Zheng, Tongzhang, Zhang, Yawei, Holford, Theodore R., Kricker, Anne, Turner, Jenny, Southey, Melissa C., Clavel, Jacqueline, Virtamo, Jarmo, Weinstein, Stephanie, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Vermeulen, Roel C H, Boeing, Heiner, Tjonneland, Anne, Angelucci, Emanuele, Di Lollo, Simonetta, Rais, Marco, Birmann, Brenda M., Laden, Francine, Giovannucci, Edward, Kraft, Peter, Huang, Jinyan, Ma, Baoshan, Ye, Yuanqing, Chiu, Brian C H, Sampson, Joshua, Liang, Liming, Park, Ju Hyun, Chung, Charles C., Weisenburger, Dennis D., Chatterjee, Nilanjan, Fraumeni, Joseph F., Slager, Susan L., Wu, Xifeng, De Sanjose, Silvia, Smedby, Karin E., Salles, Gilles, Skibola, Christine F., Rothman, Nathaniel, and Chanock, Stephen J.

Published
2014

58. Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Skibola, Christine F., Berndt, Sonja I., Vijai, Joseph, Conde, Lucia, Wang, Zhaoming, Yeager, Meredith, de Bakker, Paul I. W., Birmann, Brenda M., Vajdic, Claire M., Foo, Jia-Nee, Bracci, Paige M., Vermeulen, Roel C. H., Slager, Susan L., de Sanjose, Silvia, Wang, Sophia S., Linet, Martha S., Salles, Gilles, Lan, Qing, Severi, Gianluca, Hjalgrim, Henrik, Lightfoot, Tracy, Melbye, Mads, Gu, Jian, Ghesquieres, Herve, Link, Brian K., Morton, Lindsay M., Holly, Elizabeth A., Smith, Alex, Tinker, Lesley F., Teras, Lauren R., Kricker, Anne, Becker, Nikolaus, Purdue, Mark P., Spinelli, John J., Zhang, Yawei, Giles, Graham G., Vineis, Paolo, Monnereau, Alain, Bertrand, Kimberly A., Albanes, Demetrius, Zeleniuch-Jacquotte, Anne, Gabbas, Attilio, Chung, Charles C., Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Liu, Jianjun, Adami, Hans-Olov, Glimelius, Bengt, Ye, Yuanqing, Nowakowski, Grzegorz S., Dogan, Ahmet, Thompson, Carrie A., Habermann, Thomas M., Novak, Anne J., Liebow, Mark, Witzig, Thomas E., Weiner, George J., Schenk, Maryjean, Hartge, Patricia, De Roos, Anneclaire J., Cozen, Wendy, Zhi, Degui, Akers, Nicholas K., Riby, Jacques, Smith, Martyn T., Lacher, Mortimer, Villano, Danylo J., Maria, Ann, Roman, Eve, Kane, Eleanor, Jackson, Rebecca D., North, Kari E., Diver, W. Ryan, Turner, Jenny, Armstrong, Bruce K., Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, McKay, James, Brooks-Wilson, Angela R., Zheng, Tongzhang, Holford, Theodore R., Chamosa, Saioa, Kaaks, Rudolph, Kelly, Rachel S., Ohlsson, Bodil, Travis, Ruth C., Weiderpass, Elisabete, Clave, Jacqueline, Giovannucci, Edward, Kraft, Peter, Virtamo, Jarmo, Mazza, Patrizio, Cocco, Pierluigi, Ennas, Maria Grazia, Chiu, Brian C. H., Fraumeni, Joseph R., Nieters, Alexandra, Offit, Kenneth, Wu, Xifeng, Cerhan, James R., Smedby, Karin E., Chanock, Stephen J., Rothman, Nathaniel, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, Skibola, Christine F., Berndt, Sonja I., Vijai, Joseph, Conde, Lucia, Wang, Zhaoming, Yeager, Meredith, de Bakker, Paul I. W., Birmann, Brenda M., Vajdic, Claire M., Foo, Jia-Nee, Bracci, Paige M., Vermeulen, Roel C. H., Slager, Susan L., de Sanjose, Silvia, Wang, Sophia S., Linet, Martha S., Salles, Gilles, Lan, Qing, Severi, Gianluca, Hjalgrim, Henrik, Lightfoot, Tracy, Melbye, Mads, Gu, Jian, Ghesquieres, Herve, Link, Brian K., Morton, Lindsay M., Holly, Elizabeth A., Smith, Alex, Tinker, Lesley F., Teras, Lauren R., Kricker, Anne, Becker, Nikolaus, Purdue, Mark P., Spinelli, John J., Zhang, Yawei, Giles, Graham G., Vineis, Paolo, Monnereau, Alain, Bertrand, Kimberly A., Albanes, Demetrius, Zeleniuch-Jacquotte, Anne, Gabbas, Attilio, Chung, Charles C., Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Liu, Jianjun, Adami, Hans-Olov, Glimelius, Bengt, Ye, Yuanqing, Nowakowski, Grzegorz S., Dogan, Ahmet, Thompson, Carrie A., Habermann, Thomas M., Novak, Anne J., Liebow, Mark, Witzig, Thomas E., Weiner, George J., Schenk, Maryjean, Hartge, Patricia, De Roos, Anneclaire J., Cozen, Wendy, Zhi, Degui, Akers, Nicholas K., Riby, Jacques, Smith, Martyn T., Lacher, Mortimer, Villano, Danylo J., Maria, Ann, Roman, Eve, Kane, Eleanor, Jackson, Rebecca D., North, Kari E., Diver, W. Ryan, Turner, Jenny, Armstrong, Bruce K., Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, McKay, James, Brooks-Wilson, Angela R., Zheng, Tongzhang, Holford, Theodore R., Chamosa, Saioa, Kaaks, Rudolph, Kelly, Rachel S., Ohlsson, Bodil, Travis, Ruth C., Weiderpass, Elisabete, Clave, Jacqueline, Giovannucci, Edward, Kraft, Peter, Virtamo, Jarmo, Mazza, Patrizio, Cocco, Pierluigi, Ennas, Maria Grazia, Chiu, Brian C. H., Fraumeni, Joseph R., Nieters, Alexandra, Offit, Kenneth, Wu, Xifeng, Cerhan, James R., Smedby, Karin E., Chanock, Stephen J., and Rothman, Nathaniel

Published
2014

61. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Author

Berndt, Sonja I., Skibola, Christine F., Joseph, Vijai, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S., Kelly, Rachel S., Lan, Qing, Teras, Lauren R., Chatterjee, Nilanjan, Chung, Charles C., Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Armstrong, Bruce K., Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B., Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Wang, Alice H., Smedby, Karin E., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Jones, Brandt, Diver, W. Ryan, Link, Brian K., Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Holly, Elizabeth A., Smith, Martyn T., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Rabe, Kari G., Achenbach, Sara J., Vachon, Celine M., Goldin, Lynn R., Strom, Sara S., Lanasa, Mark C., Spector, Logan G., Leis, Jose F., Cunningham, Julie M., Weinberg, J. Brice, Morrison, Vicki A., Caporaso, Neil E., Norman, Aaron D., Linet, Martha S., De Roos, Anneclaire J., Morton, Lindsay M., Severson, Richard K., Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Masala, Giovanna, Weiderpass, Elisabete, Chirlaque, Mara-Dolores, Vermeulen, Roel C. H., Travis, Ruth C., Giles, Graham G., Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Zheng, Tongzhang, Holford, Theodore R., Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J., Spinelli, John J., Bertrand, Kimberly A., Laden, Francine, Giovannucci, Edward, Kraft, Peter, Kricker, Anne, Turner, Jenny, Vajdic, Claire M., Ennas, Maria Grazia, Ferri, Giovanni M., Miligi, Lucia, Liang, Liming, Sampson, Joshua, Crouch, Simon, Park, Ju-Hyun, North, Kari E., Cox, Angela, Snowden, John A., Wright, Josh, Carracedo, Angel, Lopez-Otin, Carlos, Bea, Silvia, Salaverria, Itziar, Martin-Garcia, David, Campo, Elias, Fraumeni, Joseph F., Jr., de Sanjose, Silvia, Hjalgrim, Henrik, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, Slager, Susan L., Berndt, Sonja I., Skibola, Christine F., Joseph, Vijai, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S., Kelly, Rachel S., Lan, Qing, Teras, Lauren R., Chatterjee, Nilanjan, Chung, Charles C., Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Armstrong, Bruce K., Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B., Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Wang, Alice H., Smedby, Karin E., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Jones, Brandt, Diver, W. Ryan, Link, Brian K., Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Holly, Elizabeth A., Smith, Martyn T., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Rabe, Kari G., Achenbach, Sara J., Vachon, Celine M., Goldin, Lynn R., Strom, Sara S., Lanasa, Mark C., Spector, Logan G., Leis, Jose F., Cunningham, Julie M., Weinberg, J. Brice, Morrison, Vicki A., Caporaso, Neil E., Norman, Aaron D., Linet, Martha S., De Roos, Anneclaire J., Morton, Lindsay M., Severson, Richard K., Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Trichopoulos, Dimitrios, Masala, Giovanna, Weiderpass, Elisabete, Chirlaque, Mara-Dolores, Vermeulen, Roel C. H., Travis, Ruth C., Giles, Graham G., Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Zheng, Tongzhang, Holford, Theodore R., Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J., Spinelli, John J., Bertrand, Kimberly A., Laden, Francine, Giovannucci, Edward, Kraft, Peter, Kricker, Anne, Turner, Jenny, Vajdic, Claire M., Ennas, Maria Grazia, Ferri, Giovanni M., Miligi, Lucia, Liang, Liming, Sampson, Joshua, Crouch, Simon, Park, Ju-Hyun, North, Kari E., Cox, Angela, Snowden, John A., Wright, Josh, Carracedo, Angel, Lopez-Otin, Carlos, Bea, Silvia, Salaverria, Itziar, Martin-Garcia, David, Campo, Elias, Fraumeni, Joseph F., Jr., de Sanjose, Silvia, Hjalgrim, Henrik, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, and Slager, Susan L.

Abstract

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.

Published
2013
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62. GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma

Author

Smedby, Karin E., Foo, Jia Nee, Skibola, Christine F., Darabi, Hatef, Conde, Lucia, Hjalgrim, Henrik, Kumar, Vikrant, Chang, Ellen T., Rothman, Nathaniel, Cerhan, James R., Brooks-Wilson, Angela R., Rehnberg, Emil, Irwan, Ishak D., Ryder, Lars P., Brown, Peter N., Bracci, Paige M., Agana, Luz, Riby, Jacques, Cozen, Wendy, Davis, Scott, Hartge, Patricia, Morton, Lindsay M., Severson, Richard K., Wang, Sophia S., Slager, Susan L., Fredericksen, Zachary S., Novak, Anne J., Kay, Neil E., Habermann, Thomas M., Armstrong, Bruce, Kricker, Anne, Milliken, Sam, Purdue, Mark P., Vajdic, Claire M., Boyle, Peter, Lan, Qing, Zahm, Shelia H., Zhang, Yawei, Zheng, Tongzhang, Leach, Stephen, Spinelli, John J., Smith, Martyn T., Chanock, Stephen J., Padyukov, Leonid, Alfredsson, Lars, Klareskog, Lars, Glimelius, Bengt, Melbye, Mads, Liu, Edison T., Adami, Hans-Olov, Humphreys, Keith, Liu, Jianjun, Smedby, Karin E., Foo, Jia Nee, Skibola, Christine F., Darabi, Hatef, Conde, Lucia, Hjalgrim, Henrik, Kumar, Vikrant, Chang, Ellen T., Rothman, Nathaniel, Cerhan, James R., Brooks-Wilson, Angela R., Rehnberg, Emil, Irwan, Ishak D., Ryder, Lars P., Brown, Peter N., Bracci, Paige M., Agana, Luz, Riby, Jacques, Cozen, Wendy, Davis, Scott, Hartge, Patricia, Morton, Lindsay M., Severson, Richard K., Wang, Sophia S., Slager, Susan L., Fredericksen, Zachary S., Novak, Anne J., Kay, Neil E., Habermann, Thomas M., Armstrong, Bruce, Kricker, Anne, Milliken, Sam, Purdue, Mark P., Vajdic, Claire M., Boyle, Peter, Lan, Qing, Zahm, Shelia H., Zhang, Yawei, Zheng, Tongzhang, Leach, Stephen, Spinelli, John J., Smith, Martyn T., Chanock, Stephen J., Padyukov, Leonid, Alfredsson, Lars, Klareskog, Lars, Glimelius, Bengt, Melbye, Mads, Liu, Edison T., Adami, Hans-Olov, Humphreys, Keith, and Liu, Jianjun

Abstract

Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (ORcombined = 0.64, P-combined= 2x10(-21)) located 962 bp away from rs10484561 (r(2)< 0.1 in controls). After mutual adjustment, the associations at the two SNPs remained genome-wide significant (rs2647012: ORadjusted = 0.70, P-adjusted= 4x10(-12); rs10484561: ORadjusted = 1.64, P-adjusted= 5x10(-15)). Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (ORcombined = 1.36, P-combined = 1.4x10(-7)). Our results reveal the presence of allelic heterogeneity within the HLA class II region influencing FL susceptibility and indicate a possible shared genetic etiology with diffuse large B-cell lymphoma. These findings suggest that the HLA class II region plays a complex yet important role in NHL.

Published
2011
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63. GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.

Author

Smedby, Karin E, Gibson, Greg1, Smedby, Karin E, Foo, Jia Nee, Skibola, Christine F, Darabi, Hatef, Conde, Lucia, Hjalgrim, Henrik, Kumar, Vikrant, Chang, Ellen T, Rothman, Nathaniel, Cerhan, James R, Brooks-Wilson, Angela R, Rehnberg, Emil, Irwan, Ishak D, Ryder, Lars P, Brown, Peter N, Bracci, Paige M, Agana, Luz, Riby, Jacques, Cozen, Wendy, Davis, Scott, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Wang, Sophia S, Slager, Susan L, Fredericksen, Zachary S, Novak, Anne J, Kay, Neil E, Habermann, Thomas M, Armstrong, Bruce, Kricker, Anne, Milliken, Sam, Purdue, Mark P, Vajdic, Claire M, Boyle, Peter, Lan, Qing, Zahm, Shelia H, Zhang, Yawei, Zheng, Tongzhang, Leach, Stephen, Spinelli, John J, Smith, Martyn T, Chanock, Stephen J, Padyukov, Leonid, Alfredsson, Lars, Klareskog, Lars, Glimelius, Bengt, Melbye, Mads, Liu, Edison T, Adami, Hans-Olov, Humphreys, Keith, Liu, Jianjun, Smedby, Karin E, Gibson, Greg1, Smedby, Karin E, Foo, Jia Nee, Skibola, Christine F, Darabi, Hatef, Conde, Lucia, Hjalgrim, Henrik, Kumar, Vikrant, Chang, Ellen T, Rothman, Nathaniel, Cerhan, James R, Brooks-Wilson, Angela R, Rehnberg, Emil, Irwan, Ishak D, Ryder, Lars P, Brown, Peter N, Bracci, Paige M, Agana, Luz, Riby, Jacques, Cozen, Wendy, Davis, Scott, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Wang, Sophia S, Slager, Susan L, Fredericksen, Zachary S, Novak, Anne J, Kay, Neil E, Habermann, Thomas M, Armstrong, Bruce, Kricker, Anne, Milliken, Sam, Purdue, Mark P, Vajdic, Claire M, Boyle, Peter, Lan, Qing, Zahm, Shelia H, Zhang, Yawei, Zheng, Tongzhang, Leach, Stephen, Spinelli, John J, Smith, Martyn T, Chanock, Stephen J, Padyukov, Leonid, Alfredsson, Lars, Klareskog, Lars, Glimelius, Bengt, Melbye, Mads, Liu, Edison T, Adami, Hans-Olov, Humphreys, Keith, and Liu, Jianjun

Abstract

Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (OR(combined) = 0.64, P(combined) = 2 × 10(-21)) located 962 bp away from rs10484561 (r(2)<0.1 in controls). After mutual adjustment, the associations at the two SNPs remained genome-wide significant (rs2647012:OR(adjusted) = 0.70, P(adjusted) = 4 × 10(-12); rs10484561:OR(adjusted) = 1.64, P(adjusted) = 5 × 10(-15)). Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (OR(combined) = 1.36, P(combined) = 1.4 × 10(-7)). Our results reveal the presence of allelic heterogeneity within the HLA class II region influencing FL susceptibility and indicate a possible shared genetic etiology with diffuse large B-cell lymphoma. These findings suggest that the HLA class II region plays a complex yet important role in NHL.

Published
2011

66. A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines.

Author

Jianqing Zhang, Riby, Jacques E., Lucia Conde, Grizzle, William E., Xiangqin Cui, and Skibola, Christine F.

Subjects
AUTOPHAGY, ALGAE, APOPTOSIS, BREAST tumors, CELL lines, CELLULAR signal transduction, ESTRADIOL, ESTROGEN antagonists, OVARIAN tumors, RESEARCH funding, T-test (Statistics), WESTERN immunoblotting, PLANT extracts, ENDOMETRIAL tumors, DATA analysis software, GENE expression profiling, DESCRIPTIVE statistics
Abstract

Background: We previously reported the anti-estrogenic activity of the brown seaweed, Fucus vesiculosus. The present study aimed to further investigate its anti-estrogenic modes of action and to assess other potentially biologically relevant anti-tumorigenic effects in estrogen receptor (ER)-dependent and -independent female cancer cell lines. Methods: The CALUX® assay was used to determine the effect of a F. vesiculosus extract (FVE) on activation of the ER. Aromatase enzymatic activity was measured to determine the potential effect of FVE on estradiol (E2) biosynthesis. Transcriptional activity profiling of 248 genes involved in cancer, immunity, hormonal regulation, protein phosphorylation, transcription, metabolism, and cellular structure was conducted using the NanoString nCounter® analysis system in FVE-treated breast, ovarian and endometrial cancer cell lines. The effects of FVE on cell viability, morphology, membrane integrity, mitochondrial toxicity, induction of apoptotic and autophagic markers, and cell signaling were also analyzed. Results: In co-treatments with 12.5 pM (EC50) E2, FVE (2 %) reduced ER activation by 50 %, exhibiting potent ER antagonistic effects. FVE inhibited aromatase activity in an in vitro assay (IC50 2.0 %). ER-dependent and -independent cancer cell lines showed significantly decreased viability that correlated with increasing FVE concentrations and altered morphological features suggestive of apoptosis and autophagy. Expression of genes that were significantly altered by FVE (p < 0.05) revealed predominantly apoptotic, autophagic and kinase signaling pathways. FVE also effectively inhibited the phosphorylation of Akt, resulting in reduced mTORC1 activities to stimulate autophagy in cells. Concentration-dependent cleavage of PARP and induction of caspase-3 and -7 activities were observed in MDA-MB-231 cells supporting a role for FVE in the promotion of apoptosis. Conclusions: Our study provides new insights into the anti-estrogenic activity of F. vesiculosus. Moreover, the induction of autophagy and apoptosis on breast, endometrial and ovarian cancer cell lines suggests additional anti-tumorigenic actions of FVE that are independent of ER status in female cancers. [ABSTRACT FROM AUTHOR]

Published
2016
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67. Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium

Author

Gibson, Todd M., primary, Smedby, Karin E., additional, Skibola, Christine F., additional, Hein, David W., additional, Slager, Susan L., additional, de Sanjosé, Silvia, additional, Vajdic, Claire M., additional, Zhang, Yawei, additional, Chiu, Brian C.-H., additional, Wang, Sophia S., additional, Hjalgrim, Henrik, additional, Nieters, Alexandra, additional, Bracci, Paige M., additional, Kricker, Anne, additional, Zheng, Tongzhang, additional, Kolar, Carol, additional, Cerhan, James R., additional, Darabi, Hatef, additional, Becker, Nikolaus, additional, Conde, Lucia, additional, Holford, Theodore R., additional, Weisenburger, Dennis D., additional, De Roos, Anneclaire J., additional, Butterbach, Katja, additional, Riby, Jacques, additional, Cozen, Wendy, additional, Benavente, Yolanda, additional, Palmers, Casey, additional, Holly, Elizabeth A., additional, Sampson, Joshua N., additional, Rothman, Nathaniel, additional, Armstrong, Bruce K., additional, and Morton, Lindsay M., additional

Published
2012
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70. Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma

Author

Skibola, Christine F, primary, Bracci, Paige M, additional, Halperin, Eran, additional, Conde, Lucia, additional, Craig, David W, additional, Agana, Luz, additional, Iyadurai, Kelly, additional, Becker, Nikolaus, additional, Brooks-Wilson, Angela, additional, Curry, John D, additional, Spinelli, John J, additional, Holly, Elizabeth A, additional, Riby, Jacques, additional, Zhang, Luoping, additional, Nieters, Alexandra, additional, Smith, Martyn T, additional, and Brown, Kevin M, additional

Published
2009
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80. PRRC2Aand BCL2L11gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

Author

Nieters, Alexandra, Conde, Lucia, Slager, Susan L., Brooks-Wilson, Angela, Morton, Lindsay, Skibola, Danica R., Novak, Anne J., Riby, Jacques, Ansell, Stephen M., Halperin, Eran, Shanafelt, Tait D., Agana, Luz, Wang, Alice H., De Roos, Anneclaire J., Severson, Richard K., Cozen, Wendy, Spinelli, John, Butterbach, Katja, Becker, Nikolaus, de Sanjose, Silvia, Benavente, Yolanda, Cocco, Pierluigi, Staines, Anthony, Maynadié, Marc, Foretova, Lenka, Boffetta, Paolo, Brennan, Paul, Lan, Qing, Zhang, Yawei, Zheng, Tongzhang, Purdue, Mark, Armstrong, Bruce, Kricker, Anne, Vajdic, Claire M., Grulich, Andrew, Smith, Martyn T., Bracci, Paige M., Chanock, Stephen J., Hartge, Patricia, Cerhan, James R., Wang, Sophia S., Rothman, Nathaniel, and Skibola, Christine F.

Abstract

Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, Prandom = 2.21 × 10−11), with similar risk estimates for common B-cell subtypes. PRRC2Ars3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68, Prandom = 1.07 × 10−9) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes.

Published
2012
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83. The effect of exercise on fructose absorption.

Author

Takuji Fujisawa, Mulligan, Kathleen, Wada, Leslie, Schumacher, Laurie, Riby, Jacques, and Kretchmer, Norman

Subjects
FRUCTOSE in human nutrition, EXERCISE physiology, PLACEBOS, HYDROGEN in the body, MALABSORPTION syndromes
Abstract

The effect of exercise on intestinal absorption of fructose was evaluated in 10 subjects after they consumed four beverages. each containing a total of 50 g carbohydrate: 100% fructose (100F), 95% fructose and 5% glucose (95F), 70% fructose and 30% glucose (70F), and 100% glucose (100G), as well as a water placebo. With 100F and 95F. breath hydrogen, which is an index of incomplete absorption. increased significantly in all subjects. In contrast. hydrogen excretion did not increase in any subject after consumption of 100G or water, or in five of seven subjects who consumed 70F. The rapid increase in hydrogen excretion observed when consumption of 100F was followed by exercise was not noted during a comparable nonexercise trial. These data suggest that intestinal capacity for absorption of fructose is readily saturated after ingestion of amounts as small as 50 g and that exercise. which reduces intestinal transit time. can cause incomplete absorption of fructose. [ABSTRACT FROM AUTHOR]

Published
1993
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84. Activation and Potentiation of Interferon-γ Signaling by 3,3'-Diindolylmethane in MCF-7 Breast Cancer Cells

Author

Riby, Jacques E., Xue, Ling, Chatterji, Urmi, Bjeldanes, Erik L., Firestone, Gary L., and Bjeldanes, Leonard F.

Abstract

3,3'-Diindolylmethane (DIM), a natural autolytic product in plants of the Brassica genus, including broccoli, cauliflower, and Brussels sprouts, exhibits promising cancer protective activities, especially against mammary neoplasia in animal models. We observed previously that DIM induced a G1 cell-cycle arrest and strong induction of cell-cycle inhibitor p21 expression and promoter activity in both estrogen-responsive and -independent breast cancer cell lines. We showed recently that DIM up-regulates the expression of interferon γ (IFNγ) in human MCF-7 breast cancer cells. This novel effect may contribute to the anticancer effects of DIM because IFNγ plays an important role in preventing the development of primary and transplanted tumors. In this study, we observed that DIM activated the IFNγ signaling pathway in human breast cancer cells. DIM activated the expression of the IFNγ receptor (IFNGR1) and IFNγ-responsive genes p56- and p69-oligoadenylate synthase (OAS). In cotreatments with IFNγ, DIM produced an additive activation of endogenous p69-OAS and of an OAS-Luc reporter and a synergistic activation of a GAS-Luc reporter. DIM synergistically augmented the IFNγ induced phosphorylation of signal transducer and activator of transcription factor 1, further evidence of DIM activation of the IFNγ pathway. DIM and IFNγ produced an additive inhibition of cell proliferation and a synergistic increase in levels of major histocompatibility complex class-1 (MHC-1) expression, accompanied by increased levels of mRNAs of MHC-1-associated proteins and transporters. These results reveal novel immune activating and potentiating activities of DIM in human tumor cells that may contribute to the established effectiveness of this dietary indole against various tumors types.

Published
2006

85. Additional file 1: Table S1. of A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines

Author

Jianqing Zhang, Riby, Jacques, Conde, Lucia, Grizzle, William, Xiangqin Cui, and Skibola, Christine

Subjects
3. Good health
Abstract

248 genes analyzed for expression profiling (Nanostring™ nCounter®) and 6 housekeeping reference genes. Figure S1. Assays of toxicity. (A) FVE effects on membrane permeability and mitochondrial ATP. (B) Digitonin used as positive control for primary necrosis. (C) CCCP used as positive control for mitochondrial toxicity. Figure S2. Morphological alterations. (A) FVE-untreated and (B) -treated cells with 1.0 % FVE, 48 hr. Figure S3. Heatmap of differential mRNA expression following FVE treatment at 0.25 % and 1.0 % (4 hr) in MCF-7, T47D, MDA-MB-231, HEC-1-B, RL95-2 and OVCAR-3 cell lines; significance level, p 3 independent Western blots normalized by β-actin levels; *p 3 independent Western blots normalized by β-actin levels; *p

86. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Author

Berndt, Sonja I., Skibola, Christine F., Joseph, Vijai, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S., Kelly, Rachel S., Lan, Qing, Teras, Lauren R., Chatterjee, Nilanjan, Chung, Charles C., Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Armstrong, Bruce K., Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B., Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Wang, Alice H., Smedby, Karin E., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Jones, Brandt, Diver, W. Ryan, Link, Brian K., Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Holly, Elizabeth A., Smith, Martyn T., Jackson, Rebecca D. J., Tinker, Lesley F., Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadié, Marc, McKay, James D., and Staines, Anthony

Subjects
Genòmica, Leucèmia limfocítica crònica, Chronic lymphocytic leukemia, Genomics

87. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Author

Glimelius, Bengt, Machado, Moara, Allmer, Cristine, Benavente, Yolanda, Turner, Jenny, Spinelli, John J., Kricker, Anne, Wu, Xifeng, Maynadie, Marc, Liebow, Mark, Chanock, Stephen J., Kaaks, Rudolph, McKay, James, Cozen, Wendy, Weiner, George J., Vajdic, Claire M., Chang, Ellen T., Chaffee, Kari G., Camp, Nicola J., Chirlaque, Maria-Dolores, Severson, Richard K., Weinstein, Stephanie, Shanafelt, Tait D., Ferri, Giovanni M., Gu, Jian, Ennas, Maria Grazia, Diver, W. Ryan, Zhi, Degui, Snowden, John A., Park, Ju-Hyun, Hjalgrim, Henrik, Foretova, Lenka, Becker, Nikolaus, Kelly, Rachel S., Connors, Joseph M., Morton, Lindsay M., Wang, Sophia S., Link, Brian K., Brennan, Paul, Vachon, Celine M., Clavel, Jacqueline, Ma, Baoshan, Virtamo, Jarmo, De Roos, Anneclaire J., Glenn, Martha, Vineis, Paolo, Cunningham, Julie M., Strom, Sara S., Achenbach, Sara J., Tinker, Lesley F., Holford, Theodore R., Rothman, Nathaniel, Offit, Kenneth, Lawrence, Charles, Cannon-Albright, Lisa A., Curtin, Karen, Miligi, Lucia, Burdett, Laurie, Skibola, Christine F., Kraft, Peter, Boffetta, Paolo, Arnett, Donna K., Wright, Josh, Kay, Neil E., Bracci, Paige M., Riboli, Elio, Monnereau, Alain, Southey, Melissa C., Teras, Lauren R., Ye, Yuanqing, Casabonne, Delphine, Chatterjee, Nilanjan, Goldin, Lynn R., Smedby, Karin E., Nieters, Alexandra, Vijai, Joseph, Purdue, Mark P., Gascoyne, Randy D., Weiderpass, Elisabete, Caporaso, Neil E., Zeleniuch-Jacquotte, Anne, Slager, Susan L., Zheng, Tongzhang, De Sanjose, Silvia, Call, Timothy G., Hartge, Patricia, Montalvan, Rebecca, Hutchinson, Amy, Travis, Ruth C., Leis, Jose F., Melbye, Mads, Novak, Anne J., Masala, Giovanna, Yeager, Meredith, Fraumeni, Joseph F., Leach, Justin M., Huang, Jinyan, Cocco, Pierluigi, Sala, Nuria, Giles, Graham G., Brooks-Wilson, Angela R., Cerhan, James R., Wang, Zhaoming, Milne, Roger L., Giovannucci, Edward, Maria, Ann, Albanes, Demetrius, Birmann, Brenda M., Bertrand, Kimberly A., Weinberg, J. Brice, Berndt, Sonja I., North, Kari E., Cox, Angela, Villano, Danylo J., Crouch, Simon, Jackson, Rebecca D., Adami, Hans-Olov, Holly, Elizabeth A., Zhang, Yawei, Staines, Anthony, Vermeulen, Roel C.H., Liang, Liming, Lan, Qing, Norman, Aaron D., Riby, Jacques, and Conde, Lucia

Subjects
3. Good health
Abstract

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P

88. Additional file 1: Table S1. of A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines

Author

Jianqing Zhang, Riby, Jacques, Conde, Lucia, Grizzle, William, Xiangqin Cui, and Skibola, Christine

Subjects
3. Good health
Abstract

248 genes analyzed for expression profiling (Nanostring™ nCounter®) and 6 housekeeping reference genes. Figure S1. Assays of toxicity. (A) FVE effects on membrane permeability and mitochondrial ATP. (B) Digitonin used as positive control for primary necrosis. (C) CCCP used as positive control for mitochondrial toxicity. Figure S2. Morphological alterations. (A) FVE-untreated and (B) -treated cells with 1.0 % FVE, 48 hr. Figure S3. Heatmap of differential mRNA expression following FVE treatment at 0.25 % and 1.0 % (4 hr) in MCF-7, T47D, MDA-MB-231, HEC-1-B, RL95-2 and OVCAR-3 cell lines; significance level, p 3 independent Western blots normalized by β-actin levels; *p 3 independent Western blots normalized by β-actin levels; *p

89. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Author

Berndt, Sonja I., Skibola, Christine F., Joseph, Vijai, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S., Kelly, Rachel S., Lan, Qing, Teras, Lauren R., Chatterjee, Nilanjan, Chung, Charles C., Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Armstrong, Bruce K., Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B., Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Wang, Alice H., Smedby, Karin E., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Jones, Brandt, Diver, W. Ryan, Link, Brian K., Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Holly, Elizabeth A., Smith, Martyn T., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, and Staines, Anthony

Subjects
Genòmica, Leucèmia limfocítica crònica, Chronic lymphocytic leukemia, Genomics
Abstract

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.

90. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Author

Berndt, Sonja I., Skibola, Christine F., Joseph, Vijai, Camp, Nicola J., Nieters, Alexandra, Wang, Zhaoming, Cozen, Wendy, Monnereau, Alain, Wang, Sophia S., Kelly, Rachel S., Lan, Qing, Teras, Lauren R., Chatterjee, Nilanjan, Chung, Charles C., Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Armstrong, Bruce K., Cocco, Pierluigi, Zhang, Yawei, Severi, Gianluca, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdette, Laurie, Yuenger, Jeffrey, Hutchinson, Amy, Jacobs, Kevin B., Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Wang, Alice H., Smedby, Karin E., Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Jones, Brandt, Diver, W. Ryan, Link, Brian K., Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Holly, Elizabeth A., Smith, Martyn T., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, and Universitat de Barcelona

Subjects
Genòmica, Leucèmia limfocítica crònica, Chronic lymphocytic leukemia, Genomics
Abstract

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.

93. Serum protein profiling in diffuse large B-cell lymphoma.

Author

Riby J, Mobley J, Zhang J, Bracci PM, and Skibola CF

Subjects
Adiponectin metabolism, Aged, Aged, 80 and over, Case-Control Studies, Chromatography, High Pressure Liquid, Enzyme-Linked Immunosorbent Assay, Extracellular Matrix Proteins metabolism, Heparan Sulfate Proteoglycans metabolism, Humans, Lipopolysaccharide Receptors metabolism, Lymphoma, Large B-Cell, Diffuse blood, Mass Spectrometry, Middle Aged, Peptides analysis, Pilot Projects, Blood Proteins metabolism, Lymphoma, Large B-Cell, Diffuse pathology
Abstract

Purpose: The aim of this pilot study was to conduct a nontargeted exploratory proteomics profiling analysis on sera obtained from patients diagnosed with diffuse large B-cell lymphoma (DLBCL) with the goal of identifying disease-specific biomarkers., Experimental Design: Sera from 87 participants (57 chemotherapy-naïve diffuse DLBCL patients, 30 controls frequency-matched by age group and World Health Organization (WHO) BMI categories) that were part of a large San Francisco Bay Area case-control study of non-Hodgkin lymphoma were analyzed by liquid chromatography combined with tandem mass spectrometry., Results: Thirty-five proteins (p-adjusted <0.05) were identified as differentially abundant between the DLBCL patients at various disease stages as compared to the controls. Of these, five proteins were randomly selected for further confirmation by ELISA: adiponectin (AdipoQ), cluster of differentiation 14 (CD14), heparin sulfate proteoglycan core protein (HSPG2), extracellular matrix 1 (ECM1), and alpha-1-antichymotrypsin (ACT). These proteins were statistically significantly elevated by 68.8, 37.0, 61.6, 68.0, and 32.0%, respectively, in DLBCL patient sera as compared to controls., Conclusion and Clinical Relevance: These preliminary data when combined with other cancer-related data regarding these proteins warrant continued research in clinical and large prospective studies to clarify the role for these biomarkers in DLBCL pathogenesis and/or prognosis., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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94. Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells.

Author

Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, and Bjeldanes LF

Subjects
2',5'-Oligoadenylate Synthetase genetics, Cell Proliferation drug effects, Gene Expression drug effects, Genes, Reporter, Humans, Interferon-gamma genetics, Interferon-gamma metabolism, Interferon-gamma pharmacology, Phosphorylation, Receptors, Interferon genetics, STAT1 Transcription Factor metabolism, Transcription, Genetic, Tumor Cells, Cultured, Interferon gamma Receptor, Anticarcinogenic Agents pharmacology, Breast Neoplasms immunology, Histocompatibility Antigens Class I metabolism, Indoles pharmacology, Receptors, Interferon metabolism, Signal Transduction drug effects
Abstract

3,3'-Diindolylmethane (DIM), a natural autolytic product in plants of the Brassica genus, including broccoli, cauliflower, and Brussels sprouts, exhibits promising cancer protective activities, especially against mammary neoplasia in animal models. We observed previously that DIM induced a G(1) cell-cycle arrest and strong induction of cell-cycle inhibitor p21 expression and promoter activity in both estrogen-responsive and -independent breast cancer cell lines. We showed recently that DIM up-regulates the expression of interferon gamma (IFNgamma) in human MCF-7 breast cancer cells. This novel effect may contribute to the anticancer effects of DIM because IFNgamma plays an important role in preventing the development of primary and transplanted tumors. In this study, we observed that DIM activated the IFNgamma signaling pathway in human breast cancer cells. DIM activated the expression of the IFNgamma receptor (IFNGR1) and IFNgamma-responsive genes p56- and p69-oligoadenylate synthase (OAS). In cotreatments with IFNgamma, DIM produced an additive activation of endogenous p69-OAS and of an OAS-Luc reporter and a synergistic activation of a GAS-Luc reporter. DIM synergistically augmented the IFNgamma induced phosphorylation of signal transducer and activator of transcription factor 1, further evidence of DIM activation of the IFNgamma pathway. DIM and IFNgamma produced an additive inhibition of cell proliferation and a synergistic increase in levels of major histocompatibility complex class-1 (MHC-1) expression, accompanied by increased levels of mRNAs of MHC-1-associated proteins and transporters. These results reveal novel immune activating and potentiating activities of DIM in human tumor cells that may contribute to the established effectiveness of this dietary indole against various tumors types.

Published
2006
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