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930 results on '"Reverchon, Ernesto"'

73. Production of PEGylated Vancomycin-Loaded Niosomes by a Continuous Supercritical CO 2 Assisted Process.

Author

Baldino, Lucia, Riccardi, Domenico, and Reverchon, Ernesto

Subjects
CARBON dioxide, VANCOMYCIN, OILSEEDS
Abstract

Niosomes are arousing significant interest thanks to their low cost, high biocompatibility, and negligible toxicity. In this work, a supercritical CO2-assisted process was performed at 100 bar and 40 °C to produce niosomes at different Span 80/Tween 80 weight ratios. The formulation of cholesterol and 80:20 Span 80/Tween 80 was selected to encapsulate vancomycin, used as a model active compound, to perform a drug release rate comparison between PEGylated and non-PEGylated niosomes. In both cases, nanometric vesicles were obtained, i.e., 214 ± 59 nm and 254 ± 73 nm for non-PEGylated and PEGylated niosomes, respectively, that were characterized by a high drug encapsulation efficiency (95% for non-PEGylated and 98% for PEGylated niosomes). However, only PEGylated niosomes were able to prolong the vancomycin release time up to 20-fold with respect to untreated drug powder, resulting in a powerful strategy to control the drug release rate. [ABSTRACT FROM AUTHOR]

Published
2024
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74. Production of Photocatalytic Membranes by Supercritical Phase Inversion for the Removal of Antibiotics from Waste-Water.

Author

Guastaferro, Mariangela, Vaiano, Vincenzo, Baldino, Lucia, Cardea, Stefano, and Reverchon, Ernesto

Subjects
PHOTOCATALYSIS, ANTIBIOTICS, SEWAGE, BIOREMEDIATION, CHROMATOGRAPHIC analysis
Abstract

In recent years, scientific research has faced the numerous problems deriving from the presence of active ingredients in surface and groundwater. Traditional removal methods, such as adsorption and bioremediation, have several disadvantages; thus, in this work, membranes based on cellulose acetate loaded with Fe-N-TiO2, were tested for the photocatalytic degradation of Ceftriaxone Sodium from aqueous solution. The immobilization of the photocatalyst allows to overcome the limits of the photocatalytic process in suspension, which requires expensive and time-consuming post-treatments. Membranes were obtained by supercritical CO2 phase inversion process and were subjected to characterizations such as EDX, TGA, FT-IR, Raman spectroscopy and, subsequently, tested in adsorption tests in the dark and in the presence of visible light, to evaluate their photocatalytic activity. The variations in the concentration of the antibiotic, during the tests conducted, were monitored by HPLC chromatographic analysis. Samples with 10% and 30% by weight of Fe-N-TiO2 demonstrated relatively low adsorption efficiencies of the target contaminant, respectively equal to 22% and 18% in 180 minutes, for reasons related both to the morphology of the samples products, which changes from cellular to finger-like as the photocatalyst load increases, and to the quality of the dispersion. The membrane loaded with 20% by weight of Fe-N-TiO2 allowed a degradation of the model pollutant of 35% in 180 minutes; moreover, the reusability of the membranes was verified. The photocatalytic tests showed that the photocatalytic efficiency was highly correlated to the dispersion of the photocatalyst nanoparticles and to its loading in the polymeric membranes. [ABSTRACT FROM AUTHOR]

Published
2024
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