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587 results on '"Rehermann, Barbara"'

54. Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection

Author

Park, Su-Hyung, Veerapu, Naga Suresh, Shin, Eui-Cheol, Biancotto, Angelique, McCoy, J. Philip, Capone, Stefania, Folgori, Antonella, and Rehermann, Barbara

Subjects
T cells -- Health aspects -- Properties, Hepatitis C virus -- Control -- Genetic aspects, RNA viruses -- Properties, Biological sciences, Health
Abstract

Hepatitis C virus (HCV) is endemic in many countries due to its high propensity for establishing persistence (1). The presence of HCV-specific T cells in subjects repeatedly exposed to HCV [...]

Published
2013
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55. Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

Author

Rehermann, Barbara

Subjects
T cells -- Research -- Physiological aspects, Hepatitis, Viral -- Research -- Genetic aspects -- Development and progression, Killer cells -- Research -- Physiological aspects, Biological sciences, Health
Abstract

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause [...]

Published
2013
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60. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

Author

Rehermann, Barbara

Subjects
Immune response -- Physiological aspects, Immune response -- Research, Hepatitis C virus -- Health aspects, Hepatitis C virus -- Research, Disease transmission -- Research
Abstract

Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been made in our understanding of its life cycle and interaction with the host immune system. Much has been learned from HCV itself, which, via decades of coevolution, gained an intricate knowledge of host innate and adaptive immune responses and developed sophisticated ways to preempt, subvert, and antagonize them. This review discusses the clinical, virological, and immunological features of acute and chronic hepatitis C and the role of the immune response in spontaneous and treatment-induced HCV clearance., Historical perspective HCV was identified by Choo et al. in 1989 using the then-novel approach of molecular cloning instead of classic virus purification (1). Assays to detect HCV antibodies were [...]

Published
2009
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61. Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses

Author

Ahlenstiel, Golo, Martin, Maureen P., Gao, Xiaojiang, Carrington, Mary, and Rehermann, Barbara

Subjects
HLA histocompatibility antigens -- Physiological aspects, HLA histocompatibility antigens -- Health aspects, HLA histocompatibility antigens -- Research, Virus diseases -- Physiological aspects, Virus diseases -- Genetic aspects, Virus diseases -- Research, Histocompatibility antigens -- Physiological aspects, Histocompatibility antigens -- Health aspects, Histocompatibility antigens -- Research, Cell receptors -- Physiological aspects, Cell receptors -- Health aspects, Cell receptors -- Research
Abstract

Genetic studies suggest a role for killer cell immunoglobulin-like receptor/HLA (KIR/HLA) compound genotypes in the outcome of viral infections, but functional data to explain these epidemiological observations have not been reported. Using an in vitro model of infection with influenza A virus (IAV), we attribute functional differences in human NK cell activity to distinct KIR/HLA genotypes. Multicolor flow cytometry revealed that the HLA-C--inhibited NK cell subset in HLA-C1 homozygous subjects was larger and responded more rapidly in IFN-[gamma] secretion and CD107a degranulation assays than its counterpart in HLA-C2 homozygous subjects. The differential IFN-[gamma] response was also observed at the level of bulk NK cells and was independent of KIR3DL1/HLA-Bw4 interactions. Moreover, the differential response was not caused by differences in NK cell maturation status and phenotype, nor by differences in the type I IFN response of IAV-infected accessory cells between HLA-C1 and HLA-C2 homozygous subjects. These results provide functional evidence for differential NK cell responsiveness depending on KIR/HLA genotype and may provide useful insights into differential innate immune responsiveness to viral infections such as IAV., Introduction As part of the innate immune system, NK cells present a first line of defense against viral infections and tumors (1). NK cell effector functions, such as cytotoxicity and [...]

Published
2008

67. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C

Author

Rotman, Yaron, Noureddin, Mazen, Feld, Jordan J, Guedj, Jeremie, Witthaus, Michael, Han, Hwalih, Park, Yoon J, Park, Su-Hyung, Heller, Theo, Ghany, Marc G, Doo, Edward, Koh, Christopher, Abdalla, Adil, Gara, Naveen, Sarkar, Souvik, Thomas, Emmanuel, Ahlenstiel, Golo, Edlich, Birgit, Titerence, Rachel, Hogdal, Leah, Rehermann, Barbara, Dahari, Harel, Perelson, Alan S, Hoofnagle, Jay H, and Liang, T Jake

Published
2014
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80. A global scientific strategy to cure hepatitis B

Author

Arbuthnot, Patrick, Boonstra, Andre, Chang, Kyong-Mi, Chen, Per-Jei, Glebe, Dieter, Guidotti, Luca G., Fellay, Jacques, Ferrari, Carlo, Jansen, Louis, Lau, Daryl T Y, Lok, Anna S, Maini, Mala K, Mason, William, Matthews, Gail, Paraskevis, Dimitrios, Petersen, Jörg, Rehermann, Barbara, Shin, Eui-Cheol, Thompson, Alex, van Bömmel, Florian, Wang, Fu-Sheng, Watashi, Koichi, Yang, Hung-Chih, Yuan, Zhenghong, Yuen, Man-Fung, Block, Timothy, Miller, Veronica, Protzer, Ulrike, Bréchot, Christian, Locarnini, Stephen, Peters, Marion G, Schinazi, Raymond F, Revill, Peter A, Chisari, Francis V, Block, Joan M, Dandri, Maura, Gehring, Adam J, Guo, Haitao, Hu, Jianming, Kramvis, Anna, Lampertico, Pietro, Janssen, Harry L A, Levrero, Massimo, Li, Wenhui, Liang, T Jake, Lim, Seng-Gee, Lu, Fengmin, Penicaud, M Capucine, Tavis, John E, Thimme, Robert, and Zoulim, Fabien

Published
2019
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81. Discovery of several thousand highly diverse circular DNA viruses

Author

Tisza, Michael J, primary, Pastrana, Diana V, additional, Welch, Nicole L, additional, Stewart, Brittany, additional, Peretti, Alberto, additional, Starrett, Gabriel J, additional, Pang, Yuk-Ying S, additional, Krishnamurthy, Siddharth R, additional, Pesavento, Patricia A, additional, McDermott, David H, additional, Murphy, Philip M, additional, Whited, Jessica L, additional, Miller, Bess, additional, Brenchley, Jason, additional, Rosshart, Stephan P, additional, Rehermann, Barbara, additional, Doorbar, John, additional, Ta'ala, Blake A, additional, Pletnikova, Olga, additional, Troncoso, Juan C, additional, Resnick, Susan M, additional, Bolduc, Ben, additional, Sullivan, Matthew B, additional, Varsani, Arvind, additional, Segall, Anca M, additional, and Buck, Christopher B, additional

Published
2020
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82. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

Author

Takaki, Akinobu, Wiese, Manfred, Maertens, Geert, Depla, Erik, Seifert, Ulrike, Liebetrau, Anke, Miller, Jeffery L., Manns, Michael P., and Rehermann, Barbara

Abstract

As acute hepatitis C virus (HCV) infection is clinically inapparent in most cases, the immunologic correlates of recovery are not well defined. The cellular immune response is thought to contribute to the elimination of HCV-infected cells and a strong HCV-specific T-helper-cell (Th) response is associated with recovery from acute hepatitis C (ref. 2). However, diagnosis of resolved hepatitis C is based at present on the detection of HCV-specific antibodies and the absence of detectable HCV RNA, and detailed comparison of the humoral and cellular immune response has been hampered by the fact that patient cohorts as well as HCV strains are usually heterogeneous and that clinical data from acute-phase and long-term follow-up after infection generally are not available. We studied a cohort of women accidentally exposed to the same HCV strain of known sequence and found that circulating HCV-specific antibodies were undetectable in many patients 18-20 years after recovery, whereas HCV-specific helper and cytotoxic T-cell responses with an interferon (IFN)-[gamma]-producing (Tc1) phenotype persisted. The data indicate these HCV-specific CD4[sup. +] and CD8[sup.+] T cells are biomarkers for a prior HCV exposure and recovery. Because of undetectable antibodies against HCV, the incidence of self-limited HCV infections and recovery may be underestimated in the general population., Author(s): Akinobu Takaki [1, 6]; Manfred Wiese [2]; Geert Maertens [3]; Erik Depla [3]; Ulrike Seifert [1]; Anke Liebetrau [2]; Jeffery L. Miller [4]; Michael P. Manns [1]; Barbara Rehermann [...]

Published
2000
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