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51. Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity

Author

Vicente, Cláudia, Thibessard, Annabelle, Lorenzi, Jean-Noël, Benhadj, Mabrouka, Hotel, Laurence, Gacemi-Kirane, Djamila, Lespinet, Olivier, Leblond, Pierre, Aigle, Bertrand, Dynamique des Génomes et Adaptation Microbienne (DynAMic), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Badji Mokhtar Annaba (UBMA), French National Research Agency ANR StreptofluxANR-07-BLAN-0096, ANR MiGenIs ANR-13-BSV6-0006, Region Grand Est, IMPACT BIOMOLECULES, ANR-15-IDEX-0004,LUE,Isite LUE(2015), ANR-07-BLAN-0096,StreptoFlux,Gene flux in Streptomyces: conjugative transfer, chromosomal recombination, and impact of biotic factors.(2007), ANR-13-BSV6-0009,MiGenIs,Recherche de nouveaux gènes du métabolisme secondaire par exploration d'ilots génomiques(2013), European Project: 609398,EC:FP7:PEOPLE,FP7-PEOPLE-2013-COFUND,AGREENSKILLSPLUS(2014), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA), Université Badji Mokhtar - Annaba [Annaba] (UBMA), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), ANR-15-IDEX-04-LUE,LUE,Lorraine Université d'Excellence(2016), and ANR-07-BLAN-0096,BLANC,Gene flux in Streptomyces: conjugative transfer, chromosomal recombination, and impact of biotic factors.(2007)

Subjects
biosynthetic gene cluster, génomique comparative, [SDV]Life Sciences [q-bio], Communication, specialized metabolites, lcsh:RM1-950, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Streptomyces, lcsh:Therapeutics. Pharmacology, strain, métabolite, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MULTILOCUS SEQUENCE-ANALYSIS, NATURAL-PRODUCT, COELICOLOR, EXPRESSION, LIVIDANS, FAMILY, CLADE, DNA, antimicrobien
Abstract

International audience; Specialized metabolites are of great interest due to their possible industrial and clinical applications. The increasing number of antimicrobial resistant infectious agents is a major health threat and therefore, the discovery of chemical diversity and new antimicrobials is crucial. Extensive genomic data from Streptomyces spp. confirm their production potential and great importance. Genome sequencing of the same species strains indicates that specialized metabolite biosynthetic gene cluster (SMBGC) diversity is not exhausted, and instead, a pool of novel specialized metabolites still exists. Here, we analyze the genome sequence data from six phylogenetically close Streptomyces strains. The results reveal that the closer strains are phylogenetically, the number of shared gene clusters is higher. Eight specialized metabolites comprise the core metabolome, although some strains have only six core gene clusters. The number of conserved gene clusters common between the isolated strains and their closest phylogenetic counterparts varies from nine to 23 SMBGCs. However, the analysis of these phylogenetic relationships is not affected by the acquisition of gene clusters, probably by horizontal gene transfer events, as each strain also harbors strain-specific SMBGCs. Between one and 15 strain-specific gene clusters were identified, of which up to six gene clusters in a single strain are unknown and have no identifiable orthologs in other species, attesting to the existing SMBGC novelty at the strain level.

Published
2018
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52. Output injection filtering redesign in high-gain observers

Author

Daniele Astolfi, Luca Zaccarian, Marc Jungers, Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Équipe Méthodes et Algorithmes en Commande (LAAS-MAC), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J), University of Trento [Trento], Region Grand-Est, CaRiTRo, grant PowerLyap, Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), and Université de Toulouse (UT)

Subjects
0209 industrial biotechnology, High-gain antenna, Observer (quantum physics), Noise measurement, Computer science, 020208 electrical & electronic engineering, 02 engineering and technology, Filter (signal processing), Dynamical system, Term (time), Noise, 020901 industrial engineering & automation, Control theory, Convergence (routing), 0202 electrical engineering, electronic engineering, information engineering, [INFO.INFO-SY]Computer Science [cs]/Systems and Control [cs.SY]
Abstract

International audience; We propose a new paradigm to redesign high-gain observers in order to improve performances in the presence of measurement noise. In particular, instead of driving the observer by means of a standard output injection term, we filter it with a dynamical system having good filtering properties. In this first preliminary result we also select the filter in order to address numerical challenges.

Published
2018

53. Chemo-enzymatic synthesis of renewable sterically-hindered phenolic antioxidants with tunable polarity from lignocellulose and vegetal oil components

Author

Sandra Domenek, Florent Allais, Louis Hollande, Agro-Biotechnologies Industrielles (ABI), AgroParisTech, Ingénierie, Procédés, Aliments (GENIAL), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), Grand Reims, Conseil General de la Marne, Region Grand Est, and Allais, Florent

Subjects
Antioxidant, antioxidant, DPPH, medicine.medical_treatment, [SDV]Life Sciences [q-bio], CAL-B, 02 engineering and technology, Lignin, 7. Clean energy, 01 natural sciences, Antioxidants, lcsh:Chemistry, ferulic acid, fatty acid ethyl esters, Ferulic acid, chemistry.chemical_compound, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Organic chemistry, lcsh:QH301-705.5, Spectroscopy, Candida, biology, General Medicine, 021001 nanoscience & nanotechnology, Computer Science Applications, 0210 nano-technology, Thermogravimetric analysis, Coumaric Acids, 010402 general chemistry, Article, Catalysis, Fungal Proteins, Inorganic Chemistry, Phenols, Glycerol, medicine, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Thermal stability, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Physical and Theoretical Chemistry, Molecular Biology, Esterification, Organic Chemistry, Lipase, Butylated Hydroxytoluene, biology.organism_classification, 0104 chemical sciences, lcsh:Biology (General), lcsh:QD1-999, chemistry, Candida antarctica, Oils
Abstract

Despite their great antioxidant activities, the use of natural phenols as antioxidant additives for polyolefins is limited owing to their weak thermal stability and hydrophilic character. Herein, we report a sustainable chemo-enzymatic synthesis of renewable lipophilic antioxidants specifically designed to overcome these restrictions using naturally occurring ferulic acid (found in lignocellulose) and vegetal oils (i.e., lauric, palmitic, stearic acids, and glycerol) as starting materials. A predictive Hansen and Hildebrand parameters-based approach was used to tailor the polarity of newly designed structures. A specific affinity of Candida antarctica lipase B (CAL-B) towards glycerol was demonstrated and exploited to efficiently synthesized the target compounds in yields ranging from 81 to 87%. Antiradical activity as well as radical scavenging behavior (H atom-donation, kinetics) of these new fully biobased additives were found superior to that of well-established, commercially available fossil-based antioxidants such as Irganox 1010&reg, and Irganox 1076&reg, Finally, their greater thermal stabilities (302 &lt, Td5% &lt, 311 &deg, C), established using thermal gravimetric analysis, combined with their high solubilities and antioxidant activities, make these novel sustainable phenolics a very attractive alternative to current fossil-based antioxidant additives in polyolefins.

Published
2018
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54. Facing global change

Author

Basso, Veronica, de Freitas Pereira, Maira, Maillard, François, Mallerman, Julieta, Mangeot-Peter, Lauralie, ZHANG, Feng, Bonnot, Clémence, Interactions Arbres-Microorganismes (IAM), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), LabEx ARBRE : Advanced Research on the Biology of Tree and Forest Ecosystems ([LabEx ARBRE]), Office National des Forêts (ONF)-AgroParisTech-Institut National de la Recherche Agronomique (INRA)-Centre National de la Propriété Forestière-CRITT Bois-European Forest Institute = Institut Européen de la Forêt = Euroopan metsäinstituutti (EFI)-Université de Lorraine (UL), SILVA (SILVA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL)-AgroParisTech, Instituto de Investigaciones Fisiologicas y Ecologicas Vinculadas a la Agricultura (IFEVA), Facultad de Agronomía [Buenos Aires], Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), New Phytologist Trust, LabEx ARBRE ANR-11-LABX-0002-01, Region Grand-Est, University of Lorraine, Genomic Science Programme of the US Department of Energy as part of the Plant-Microbe Interfaces Scientific Focus Area, ANPCyT PICT 2015-1231 PICT 2016-1780 University of Buenos Aires (UBACyT), CONICET of Argentina, ANR-11-LABX-0002,ARBRE,Recherches Avancées sur l'Arbre et les Ecosytèmes Forestiers(2011), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Office National des Forêts (ONF)-Université de Lorraine (UL)-Centre National de la Propriété Forestière-CRITT Bois-European Forest Institute = Institut Européen de la Forêt = Euroopan metsäinstituutti (EFI), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Université de Lorraine (UL)

Subjects
SECURITY, IMPACTS, anthropocene, CLIMATE-CHANGE, PESTS, production agricole, [SDV]Life Sciences [q-bio], durabilité, sustainability, ACCLIMATION, agricultural production, changement global, GROWTH, RESISTANCE, DROUGHT
Abstract

We entered the Anthropocene with the industrial revolution. This geological era is defined by the unprecedented impact of human activities on the planet's geochemical cycles, making us the main driving force of Earth environmental changes (Crutzen, 2002; Steffen et al., 2011). Since the middle of the twentieth century the human population has tripled, reaching seven billion today and probably 10 billion by 2050 (United Nations, 2015). This dramatic increase, associated with the improvement in the welfare of the population, has led to the overexploitation of natural resources. Intensive agriculture and industrialization has resulted in global warming, modification of nutrient cycles, pollution and reduction of wilderness; and endangering the preservation of eco‐ and agro‐systems (Tilman et al., 2002; Steffen et al., 2011; Ehrlich & Harte, 2015). Today, the challenge is not only to intensify agro‐productions to feed, fuel and shelter the growing population; but to do so in spite of the consequences of climate change while lessening our impact on the supporting ecosystems (Godfray et al., 2010; Ehrlich & Harte, 2015; Byrne et al., 2018).

Published
2018
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55. Detoxification of highly acidic hemicellulosic hydrolysate from wheat straw by diananofiltration with a focus on phenolic compounds

Author

Andreia R. S. Teixeira, Marie-Laure Lameloise, Marielle Bouix, Axel Fayet, Florent Allais, Agro-Biotechnologies Industrielles (ABI), AgroParisTech, Université Paris Saclay (COmUE), Génie et Microbiologie des Procédés Alimentaires (GMPA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Ingénierie, Procédés, Aliments (GENIAL), Region Grand Est, and Conseil Departemental de la Marne and Grand Reims

Subjects
[SDV]Life Sciences [q-bio], Filtration and Separation, 02 engineering and technology, 010501 environmental sciences, Furfural, 01 natural sciences, Biochemistry, Diafiltration, Hydrolysate, Acetic acid, chemistry.chemical_compound, Hemicellulosic hydrolysate, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Osmotic pressure, General Materials Science, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Physical and Theoretical Chemistry, 0105 earth and related environmental sciences, Steam explosion, Chromatography, food and beverages, Sulfuric acid, Straw, 021001 nanoscience & nanotechnology, Nanofiltration, Phenolic compounds, chemistry, 0210 nano-technology, Detoxification
Abstract

International audience; Nanofiltration was studied for detoxification of lignocellulose hydrolysates obtained in harsh conditions. A hemicellulosic hydrolysate obtained from sulfuric acid steam explosion of wheat straw and presenting very low pH ( = 1) and high osmotic pressure (28 bar) was studied and 8 inhibitory compounds were followed, among which 4 phenolic compounds. Several polymeric nanofiltration membranes were compared for separation performances and permeabilities; DK membrane (GE Osmonics) proved suitable with high rejection of sugars ( > 99%) and lower rejections of inhibitors. Acetic acid and furfural were quasi-fully transmitted whereas the rejection of compounds ranked as follow: HMF (5-hydroxymethyl-furfural) < coumaric acid < levulinic acid < vanillin < ferulic acid < syringaldehyde with values of 40%, 50%, 60%, 80%, 90% and 98%, respectively, at a permeate flux of 14 L h(-1) m(-2). Diafiltration was carried out at a transmembrane pressure of 26 bar until 3 DV (Diafiltration Volume) to complete detoxification, and continuous and sequential-dilution modes were compared. Thanks to the permeability of the membrane to the monovalent form of sulfuric acid HSO4-, effective transmembrane pressure was increased and pH reached 2. At 3 DV, both modes showed removal performances between 92% (acetic acid and furfural) and 25% (syringaldehyde). Irreversible fouling was observed, leading to 30% permeability loss after diafiltration.

Published
2018
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56. Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor

Author

Schwartz, Mathieu, Perrot, Thomas, Aubert, Emmanuel, Dumarçay, Stéphane, Favier, Frédérique, Gérardin, Philippe, Morel-Rouhier, Mélanie, Mulliert, Guillermo, Saiag, Fanny, Didierjean, Claude, Gelhaye, Eric, Cristallographie, Résonance Magnétique et Modélisations (CRM2), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Interactions Arbres-Microorganismes (IAM), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Laboratoire d'Etude et de Recherche sur le Matériau Bois (LERMAB), Université de Lorraine (UL), ANR (ANR-11-LAS-0002-01), Centre National de la Recherche Scientifique, University of Lorraine, Region Grand Est, and Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA)

Subjects
PRUNUS-AVIUM, STRUCTURAL EVIDENCE, GLUTATHIONE TRANSFERASES, cerisier, [SDV]Life Sciences [q-bio], lcsh:Medicine, reconnaissance moléculaire, Crystallography, X-Ray, Article, cristallographie macromoléculaire, Fungal Proteins, polyphénol, Benzophenones, trametes versicolor, champignon du bois, enzyme de détoxification, Amino Acid Sequence, ADAPTATION, lcsh:Science, Glutathione Transferase, Flavonoids, Trametes, cherry tree, Binding Sites, IDENTIFICATION, Protein Stability, CRYSTALLOGRAPHY, lcsh:R, Temperature, FUNGI, Polyphenols, food and beverages, EXTRACTIVES, Wood, Metabolic Detoxication, Phase II, Protein Structure, Tertiary, Isoenzymes, Kinetics, INSECTICIDE RESISTANCE, dégradation du bois, lcsh:Q, molecular recognition, Prunus, Sequence Alignment
Abstract

Wood decay fungi have complex detoxification systems that enable them to cope with secondary metabolites produced by plants. Although the number of genes encoding for glutathione transferases is especially expanded in lignolytic fungi, little is known about their target molecules. In this study, by combining biochemical, enzymatic and structural approaches, interactions between polyphenols and six glutathione transferases from the white-rot fungus Trametes versicolor have been demonstrated. Two isoforms, named TvGSTO3S and TvGSTO6S have been deeply studied at the structural level. Each isoform shows two distinct ligand-binding sites, a narrow L-site at the dimer interface and a peculiar deep hydrophobic H-site. In TvGSTO3S, the latter appears optimized for aromatic ligand binding such as hydroxybenzophenones. Affinity crystallography revealed that this H-site retains the flavonoid dihydrowogonin from a partially purified wild-cherry extract. Besides, TvGSTO6S binds two molecules of the flavonoid naringenin in the L-site. These data suggest that TvGSTO isoforms could interact with plant polyphenols released during wood degradation.

Published
2018
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57. Bacterial weathering and its contribution to nutrient cycling in temperate forest ecosystems

Author

Philippe Oger, Stéphane Uroz, Pascale Frey-Klett, Cendrella Lepleux, Marie-Pierre Turpault, Christelle Collignon, Interactions Arbres-Microorganismes (IAM), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA), Unité de recherche Biogéochimie des Ecosystèmes Forestiers (BEF), Institut National de la Recherche Agronomique (INRA), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement [Lyon] (LGL-TPE), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Programme national Ecosphere Continentale et Cotiere EC2CORegion Grand-Est INRA Region Grand-Est ONF (Office Nationale des Forets), Programme national Ecosphere Continentale et Cotiere : EC2CO, Bureau des Ressources genetiques (BRG), Region Lorraine, INRA, Lorraine Région, ONF (Office Nationale des Forêts), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nutrient cycle, Mineral-weathering, Forest management, Biology, Plant Roots, Microbiology, Nutrient cycling, Carbon Cycle, Trees, 03 medical and health sciences, Soil, Mycorrhizae, Forest ecology, Ecosystem, Forest, Symbiosis, Weather, Molecular Biology, Phylogeny, Soil Microbiology, 030304 developmental biology, Forest floor, Minerals, 0303 health sciences, geography, geography.geographical_feature_category, Bacteria, Ecology, Temperate forest, Pyrosequencing, 04 agricultural and veterinary sciences, General Medicine, Nitrogen Cycle, 15. Life on land, Old-growth forest, Bacterial communities, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Microscopy, Electron, Scanning, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Terrestrial ecosystem, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

International audience; Unlike farmland, forests growing on acidic soils are among the terrestrial ecosystems that are the least influenced or amended by man. Forests which developed on acidic soils are characterized by an important stock of inorganic nutrients entrapped in poorly weatherable soil minerals. In this context, the mineral-weathering process is of great importance, since such minerals are not easily accessible to tree roots. To date, several bacterial genera have been noted for their ability to weather minerals and, in the case of some of them, to improve tree nutrition. Nevertheless, few studies have focused their analyses on mineral-weathering bacterial communities in relation to geochemical cycles and soil characteristics, their ecological origin, associated tree species and forest management practices. Here we discuss the heterogeneity of the mineral-weathering process in forest soils and present what is known concerning the taxonomic and functional characteristics of mineral-weathering bacteria, as well as the different locations where they have been isolated in forest soils. We also discuss the biotic and abiotic factors that may influence the distribution of these bacteria, such as the effect of tree species or forest management practices.

Published
2011
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58. Best practice guidance for antibiotic audit and feedback interventions in primary care: a modified Delphi study from the Joint Programming Initiative on Antimicrobial resistance: Primary Care Antibiotic Audit and Feedback Network (JPIAMR-PAAN).

Author

Schwartz KL, Xu AXT, Alderson S, Bjerrum L, Brehaut J, Brown BC, Bucher HC, De Sutter A, Francis N, Grimshaw J, Gunnarsson R, Hoye S, Ivers N, Lecky DM, Lindbæk M, Linder JA, Little P, Michalsen BO, O'Connor D, Pulcini C, Sundvall PD, Lundgren PT, Verbakel JY, and Verheij TJ

Subjects
Humans, Feedback, Delphi Technique, Primary Health Care, Anti-Bacterial Agents therapeutic use, Drug Resistance, Bacterial
Abstract

Background: Primary care is a critical partner for antimicrobial stewardship efforts given its high human antibiotic usage. Peer comparison audit and feedback (A&F) is often used to reduce inappropriate antibiotic prescribing. The design and implementation of A&F may impact its effectiveness. There are no best practice guidelines for peer comparison A&F in antibiotic prescribing in primary care., Objective: To develop best practice guidelines for peer comparison A&F for antibiotic prescribing in primary care in high income countries by leveraging international expertise via the Joint Programming Initiative on Antimicrobial Resistance-Primary Care Antibiotic Audit and Feedback Network., Methods: We used a modified Delphi process to achieve convergence of expert opinions on best practice statements for peer comparison A&F based on existing evidence and theory. Three rounds were performed, each with online surveys and virtual meetings to enable discussion and rating of each best practice statement. A five-point Likert scale was used to rate consensus with a median threshold score of 4 to indicate a consensus statement., Results: The final set of guidelines include 13 best practice statements in four categories: general considerations (n = 3), selecting feedback recipients (n = 1), data and indicator selection (n = 4), and feedback delivery (n = 5)., Conclusion: We report an expert-derived best practice recommendations for designing and evaluating peer comparison A&F for antibiotic prescribing in primary care. These 13 statements can be used by A&F designers to optimize the impact of their quality improvement interventions, and improve antibiotic prescribing in primary care., (© 2023. Crown.)

Published
2023
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