51. Panenteric capsule endoscopy identifies proximal small bowel disease guiding upstaging and treatment intensification in Crohn's disease: a European multicentre observational cohort study
- Author
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Uri Kopylov, Mark E. McAlindon, Rami Eliakim, Alfonso Elosua, Pierre Ellul, Ignacio Fernandez-Urien, Simon Panter, Sara Koo, Reena Sidhu, Clare Parker, Gian Eugenio Tontini, Luca Elli, and Foong Way David Tai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Treatment intensification ,Disease ,Capsule Endoscopy ,Severity of Illness Index ,Gastroenterology ,a novel panenteric capsule endoscope ,Small Bowel ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,Capsule endoscopy ,law ,Internal medicine ,Intestine, Small ,medicine ,Humans ,Small bowel disease ,Intestinal Mucosa ,endoscopy ,patient management ,PillCam Crohn's ,Inflammation ,Crohn's disease ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Endoscopy ,proximal small bowel Crohn's disease ,C-Reactive Protein ,Oncology ,030220 oncology & carcinogenesis ,Mucosal healing ,Female ,Original Article ,030211 gastroenterology & hepatology ,business ,Leukocyte L1 Antigen Complex ,Biomarkers ,Cohort study - Abstract
Background Endoscopically defined mucosal healing in Crohn's disease is associated with improved outcomes. Panenteric capsule endoscopy enables a single non‐invasive assessment of small and large bowel mucosal inflammation. Aims and Methods This multicentre observational study of patients with suspected and established Crohn's disease examined the feasibility, safety and impact on patient outcomes of panenteric capsule endoscopy in routine clinical practice. The potential role in assessment of disease severity and extent by a comparison with existing clinical and biochemical markers is examined. Results Panenteric capsule endoscopy was performed on 93 patients (71 with established and 22 with suspected Crohn's disease). A complete examination occurred in 85% (79/93). Two cases (2.8%) of capsule retention occurred in patients with established Crohn's disease. Panenteric capsule resulted in management change in 38.7% (36/93) patients, including 64.6% (32/48) of those with an established diagnosis whose disease was active, and all three patients with newly diagnosed Crohn's disease. Montreal classification was upstaged in 33.8% of patients with established Crohn's disease and mucosal healing was demonstrated in 15.5%. Proximal small bowel disease upstaged disease in 12.7% and predicted escalation of therapy (odds ratio 40.3, 95% confidence interval 3.6–450.2). Raised C‐reactive protein and faecal calprotectin were poorly sensitive in detecting active disease (0.48 and 0.59 respectively). Conclusions Panenteric capsule endoscopy was feasible in routine practice and the ability to detect proximal small bowel disease may allow better estimation of prognosis and guide treatment intensification. Panenteric capsule endoscopy may be a suitable non‐invasive endoscopic investigation in determining disease activity and supporting management decisions., Key Summary Summarise the established knowledge on this subject Biochemical and clinical markers poorly predict active disease and need for treatment escalation;Panenteric capsule endoscope is feasible, safe and has the potential to non‐invasively assess patients with Crohn's Disease. What are the significant and/or new findings of this study? Panenteric capsule endoscope can upstage disease in one‐third of patients with a threefold increase in the identification of proximal small bowel disease;Identification of proximal small bowel disease predicted treatment intensification.
- Published
- 2021