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56. Optical and morphological properties of poly(vinyl chloride)-nano-chitosan composites doped with TiO2 and Cr2O3 nanoparticles and their potential for solar energy applications.

Author

Abed, Rasheed N., Sattar, Muhammed Abdul, Hameed, Seenar S., Ahmed, Dina S., Al-Baidhani, Mohammed, Kadhom, Mohammed, Jawad, Ali H., Zainulabdeen, Khalid, Al-Mashhadani, Mohammed H., Rashad, Alaa A., and Yousif, Emad

Abstract

In the present work, the poly(vinyl chloride) (PVC)-nano-chitosan thin films were prepared, and the influence of filling Cr2O3 and TiO2 nanoparticles on the lattice was investigated. PVC and nano-chitosan (15 wt.%) were dissolved in tetrahydrofuran (THF) to ultimately form thin films by the casting method. The thin films' optical properties were characterized via a diffusive reflectance device within an approximate wavelength range of 250 to 1300 nm. Furthermore, the transmittance, reflectance, refractive index, absorption, optical conductivity, skin depth, dielectric constant, and Urbach energy were computed. The absorbance values of plain and NPs-filled thin films ranged between 92 and 99%. Also, the energy gap of films filled with NPs was reduced in the direct transmission from 3.9 to 2.9 eV and in the indirect transition from 3.0 to 2.55 eV. However, similar behavior for the Urbach energy was observed. The Fourier-transform infrared (FTIR) spectroscopy was used to study the interaction between the PVC and nano-chitosan as a new polymer composite. The X-ray powder diffraction (XRD) test showed a crystalline structure of the thin films, while the microscopic and atomic force microscopy (AFM) images demonstrated a good dispersion of nano-chitosan and NPs within the PVC lattice. The synthesized films could be good candidates for optoelectronics, glass processing, and ceramic production applications. [ABSTRACT FROM AUTHOR]

Published
2023
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57. Spectrally selective coating of nanoparticles (Co 3 O 4 :Cr 2 O 3 ) incorporated in carbon to captivate solar energy

Author

Haidar Ch. Al‐Mohammedawi, Emad Yousif, Alaa Rashad, Rasheed N. Abed, and Mustafa Abdallh

Subjects
Fluid Flow and Transfer Processes, Materials science, Band gap, business.industry, chemistry.chemical_element, Nanoparticle, engineering.material, Condensed Matter Physics, Solar energy, chemistry, Coating, Chemical engineering, engineering, Chromium oxide, business, Cobalt oxide, Carbon
Published
2020
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59. Optical properties of PVC composite modified during light exposure to give high absorption enhancement

Author

Alaa Rashad, Ali H. Jawad, Abdul Rahman N. Abed, Abas Hadawey, Rasheed N. Abed, and Emad Yousif

Subjects
010302 applied physics, chemistry.chemical_classification, Materials science, Analytical chemistry, 02 engineering and technology, Dielectric, Polymer, Molar absorptivity, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Vinyl chloride, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Attenuation coefficient, 0103 physical sciences, Materials Chemistry, Ceramics and Composites, Transmittance, 0210 nano-technology, Refractive index, Tetrahydrofuran
Abstract

Modified poly(vinyl chloride) (PVC) films have been synthesized with a simple superficial deposition by using solvent tetrahydrofuran (THF). These modified films were prepared by a casting method over a glass substrate. Different types of the amino group with a suitable aromatic aldehyde as an organic compound, which were reacted to prepare different PVC composite films. These films have been analyzed by UV-Visible spectra. The percentage of PVC was (0.25 g) with (0.05 g) amino group and aromatic aldehyde combinedly, then dissolved with (8 ml) of tetrahydrofuran (THF) at room temperature (300 K). The optical properties as absorption coefficient, reflectance, transmittance, skin depth, energy gap, refractive index, extinction coefficient, and urbach energy were studied. The transmittance value of the pure PVC film was 1.0 then declined gradually after dispersion with the compounds to the lowest value at 0.1, the reflectance also decreased. The energy gap for direct allowed decreased from (5.1 to 2.9 eV), and indirect transition decreased also from (5.0 to 2.8 eV), this behavior indicate that the modified films become work as semi-crystalline compounds toward the light. In tailoring, the optical properties, and urbach energy have been increased after mixed with PVC polymer. The scattering energy ( E d ) and the effective single oscillator ( E o ) , were decreased. In a similar manner the dielectric constant high frequency ( e ∞ ) and effective mass ( N m * ) , of dielectric constants were increased for PVC modified films. The PVC modified films are appropriate for anti-reflected coating while being good suitable in high refractive lenses and photovoltaic cells applications.

Published
2021
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60. Unraveling the binding characteristics of the anti-HIV agents abacavir, efavirenz and emtricitabine to bovine serum albumin using spectroscopic and molecular simulation approaches

Author

Amer M. Alanazi, Ali S. Abdelhameed, Ayman Alkhider, Ahmed H. Bakheit, Fahad M. Almutairi, Ibrahim A. Darwish, and Rasheed N. Herqash

Subjects
0301 basic medicine, 030103 biophysics, Efavirenz, biology, Anti hiv, Molecular simulation, Condensed Matter Physics, Emtricitabine, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Abacavir, Materials Chemistry, medicine, biology.protein, Biophysics, Physical and Theoretical Chemistry, Bovine serum albumin, Binding site, Tyrosine, Spectroscopy, medicine.drug
Abstract

In the present study the binding characteristics of abacavir (ABV), efavirenz (EFV) and emtricitabine (EMC) to bovine serum albumin (BSA) have been investigated via the use of spectroscopic tools and in silico docking studies. Those ligands were found to statically quench the intrinsic fluorescence of BSA with binding constants ranging between 1.75 and 2.36 × 104 Lmol− 1 over the studied temperatures. Fluorescence quenching results were further interpreted to obtain the thermodynamic features of the interactions which revealed spontaneous interactions between the studied ligands and BSA with ΔH° values of − 10.50, − 2.56 and − 2.89 kJmol− 1 and ΔS° values of of 47.46, 74.14 and 71.88 Jmol− 1 K− 1 for ABV, EFV and EMC, respectively. Synchronous fluorescence measurments showed that the intrinsic fuorescence of BSA was being quenched by the 3 ligands with a suggested alteration in the microenvironments around the tyrosine residues of the BSA upon binding to ABV and EMC. Furthermore, markers of the BSA binding sites were incorportated to identify the binding site(s) on BSA for ABV, EFV and EMC. It was found that ABV and EMC bind to Sudlow sites I and II on the BSA while EFV binds only to site I which was further supported with the molecular docking findings.

Published
2018
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63. Induction of apoptosis and cell cycle arrest by chloroform fraction of Juniperus phoenicea and chemical constituents analysis

Author

Barnawi, Ibrahim O., primary, Nasr, Fahd A., additional, Noman, Omar M., additional, Alqahtani, Ali S., additional, Al-zharani, Mohammed, additional, Alotaibi, Amal A., additional, Daradka, Haytham M., additional, Al-Mishari, Abdullah A., additional, Alobaid, Waleed A, additional, Alqahtani, Abdulaziz, additional, and Herqash, Rasheed N., additional

Published
2021
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67. Optical Study to Doping Carbon with TiO2 that Utilizing in Thermal Concentration

Author

Abdul Jabar N. Khalifa, Nabeel Kadim Abid Alsahib, and Rasheed N. Abed

Subjects
Materials science, chemistry, Chemical engineering, 021105 building & construction, Doping, Thermal, 0211 other engineering and technologies, chemistry.chemical_element, 02 engineering and technology, 021001 nanoscience & nanotechnology, 0210 nano-technology, Carbon
Abstract

The optical properties of TiO2/C in the district from (200-2000 nm) were examined by setting up the composites with wt. % concentration. The optical information evaluated and translated regarding the hypothesis of phonon-assisted direct electronic change; it is watched that the energy is influenced by doping sort of mineral composite utilized. The doping manufactured powders were examined through data analysis to validate the presence of these elements. This investigation for the influence of TiO2 was an addition on the microstructure of the carbon and electrical behavior of the composite was detected, this doped was gotten in a dry place at ambient temperature and its effect was studied from the physical properties of the energy gap. The optical measurement of the specimen was measured as a component of wavelength (λ), absorptivity that exhibit good results to absorb the solar energy for selective surfaces.

Published
2017
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68. Improvement the efficiency of the solar cells using nanosizing process (photochemical etching)

Author

Abdul Rahman N. Abed, Rasheed N. Abed, and Farhan Ahmed Khammas

Subjects
Materials science, integumentary system, Silicon, Photovoltaic system, technology, industry, and agriculture, food and beverages, chemistry.chemical_element, Photochemistry, law.invention, Solar cell efficiency, chemistry, law, Etching (microfabrication), Scientific method, biological sciences, Solar cell, Layer (electronics), Silicon solar cell
Abstract

The enhancement of photovoltaic (n-p/Si solar cell) has been carried out. The development is based on a surface texturing of the solar cell. The photochemical etching technique was used in the preparation of the n-side of silicon solar cell. The samples were exam were by Atomic Force Microscope ( AFM) which show that the average pores diameter in the order of 55nm, and the thickness of the etched layer changed from 1.1nm to 56nm, which cause increase the surface area of the silicon solar cells that expose of the to the illumination. The efficiency conversion of the photovoltaic (PV) was tested showing an enhancement to the change on efficiency of the silicon solar cells, the best efficiency was obtained by treating the solar cell to a solution of 15% of HF acid concentration with period of 45 minutes, with a value of (12%) while the untreated solar cell efficiency was (8.1%). The Morphological Investigation shows that the etching rate is accretion with increasing of the treatment time, but after 45 minutes the first layer of the silicon solar cell was removed which caused declining in the efficiency, the nanosize of pores and the area expose to illumination.

Published
2020
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71. Rivaroxaban for stroke prevention after embolic stroke of undetermined source

Author

Hart, Robert G, Sharma, Mukul, Mundl, Hardi, Kasner, Scott E, Bangdiwala, Shrikant I, Berkowitz, Scott D, Swaminathan, Balakumar, Lavados, Pablo, Wang, Yongjun, Wang, Yilong, Davalos, Antonio, Shamalov, Nikolay, Mikulik, Robert, Cunha, Luis, Lindgren, Arne, Arauz, Antonio, Lang, Wilfried, Czlonkowska, Anna, Eckstein, Jens, Gagliardi, Rubens J, Amarenco, Pierre, Ameriso, Sebastian F, Tatlisumak, Turgut, Veltkamp, Roland, Hankey, Graeme J, Toni, Danilo, Bereczki, Daniel, Uchiyama, Shinichiro, Ntaios, George, Yoon, Byung-Woo, Brouns, Raf, Endres, Matthias, Muir, Keith W, Bornstein, Natan, Ozturk, Serefnur, O'Donnell, Martin J, De Vries Basson, Matthys M, Pare, Guillaume, Pater, Calin, Kirsch, Bodo, Sheridan, Patrick, Peters, Gary, Weitz, Jeffrey I, Peacock, W Frank, Shoamanesh, Ashkan, Benavente, Oscar R, Joyner, Campbell, Themeles, Ellison, Connolly, Anderson DC, Stuart J., Demets, Dl, Kaste, M, Norrving, B, Wyse, Dg, Alet, M, Allende, G, Beinlich, A, Berrios, W, Bruera, G, Castro, D, Chialvo, L, Claverie, S, Contardo, L, Couto, J, Deganutto, R, Diaz, R, Dossi, D, Esnaola, M, Falco, M, Fernandez Pirrone, P, Ferrari, J, Firstenfeld, A, Galli Giqueauk, E, Gilli, M, Gonzalez, L, Gonzalez Toledo, M, Grecco, M, Halac, B, Hawkes, M, Ioli, P, Jure, L, Klein, F, Lepera, S, Lujan, S, Mackinnon, F, Marroquin, M, Martin, J, Parisi, V, Perez Leguizamon, P, Persi, G, Povedano, P, Povedano, G, Pujol Lereis, V, Radrizzani, L, Reich, E, Repetto, M, Rodriguez Lucci, F, Romano, M, Saredo, G, Schneider, M, Simonsini, C, Sumay, G, Thomson, A, Toledo, W, Torres, C, Vila, A, Abdul Rasheed, N, Anderson, C, Bailey, P, Blacker, D, Carcel, C, Clissold, B, Delcourt, C, Field, D, Gangadharan, S, Ghia, D, Kleinig, T, Leyden, J, Ly, J, Ma, H, Mackey, E, Mishra, S, Moey, A, Musuka, T, Pepper, E, Phan, T, Sabet, A, Saw, J, Singh, B, Tryambake, D, Tu, H, Wijeratne, T, Wong, A, Augustin, S, Esterbauer, M, Garnauf, M, Gasiorek, K, Gasser, S, Gaugg, M, Greisenegger, S, Harrasser, M, Heine, M, Huber, B, Joachim, B, Kapeller, P, Krebs, S, Kreuzpointer, R, Kunzmann, J, Lechner, H, Lohninger, B, Luschin, G, Macher, S, Marko, M, Matosevic, B, Mayr, A, Mismas, A, Mitrovic, N, Mutzenbach, J, Oberndorfer, S, Obmann, S, Raffelsberger, T, Roesler, C, Salletmayr, T, Serles, W, Stadler, K, Tinchon, A, Tolino, M, Verocai, V, Vigl, M, Voglsperger, B, Weber, J, Werner, P, Windt, J, Winkler, A, Wurzinger, H, Zelenka, I, Cras, P, Crols, R, De Keyser, J, De Klippel, N, De Pauw, A, De Smedt, A, Dhollander, I, Hermans, S, Ligot, N, Maqueda, V, Maqueda Maqueda, V, Naeije, G, Seynaeve, L, Soors, P, Van Daele, W, Vanacker, P, Vanderschueren, G, Willems, C, Yperzeele, L, Avelar, W, Bacellar, A, Batista, C, Bazan, R, Braga, G, Cardoso, F, Dagnino, M, Fabio, S, Ferreira Junior, G, Freitas, G, Friedrich, M, Gomes Neto, A, Guarda, S, Katsurayama, M, Machado, M, Martins, S, Meira, F, Minelli, C, Morais, R, Moro, C, Neto, O, Polin, M, Silva, D, Weiss, G, Basile, V, Beaudry, M, Berlingieri, J, Blacquiere, D, Buck, B, Chan, R, Coutts, S, Das, S, Desai, J, Ehrensperger, E, Field, T, Gladstone, D, Hachinski, V, Hassan, A, Hegedus, J, Hill, M, Jin, A, Khaw, A, Mackey, A, Maclean, G, Mandzia, J, Mann, S, Mehdiratta, M, Murphy, C, Ng, K, Oczkowski, W, Penn, A, Perera, K, Perez, Y, Pesant, Y, Phillips, S, Poppe, A, Sahlas, J, Shuaib, A, Spence, D, Sposato, L, Stotts, G, Tamayo, A, Teal, P, Wilson, L, Winder, T, Yegappan, C, Yip, S, Andreu, D, Araya, P, Bustamante, G, Figueroa, C, Gasic, K, Herrero, D, Matamala, G, Munoz, S, Olavarria, V, Pasten, J, Polanco, J, Reyes, P, Roldan, A, Salamanca, P, Silva, P, Toloza, C, Verdugo, M, Cai, K, Che, C, Chen, J, Chen, Z, Chen, T, Chen, H, Chen, X, Chen, B, Chen, G, Chen, L, Chu, F, Cui, L, Dai, C, Ding, N, Ding, J, Du, P, Du, J, Fang, L, Feng, J, Gao, Y, Geng, J, Guan, J, Hao, L, Huang, D, Huang, H, Jin, X, Jing, P, Ke, K, Li, G, Li, M, Li, S, Li, J, Liang, Z, Lin, H, Liu, K, Liu, X, Lu, Z, Ma, C, Pei, H, Qiu, J, Qu, X, Shen, W, Sun, X, Tian, J, Tong, L, Tong, Z, Wang, J, Wang, L, Wang, X, Wang, W, Wang, N, Wang, D, Wang, H, Wen, G, Weng, G, Wu, W, Wu, S, Xiao, B, Xiaopeng, W, Xiong, L, Xiong, Y, Xu, Y, Xu, J, Xu, Z, Yang, L, Yang, Y, Yang, X, Yang, J, Yang, Q, Yang, B, Zhang, C, Zhang, B, Zhang, Y, Zhang, S, Zhang, M, Zhang, X, Zhang, J, Zhao, L, Zhou, L, Bar, M, Barteys, M, Bartolottiova, T, Carek, M, Ferencova, K, Fiksa, J, Gallo, J, Goldemund, D, Hanouskova, L, Herzig, R, Hon, P, Jankovych, J, Jura, R, Kadlcikova, J, Kemlink, D, Kopecky, S, Krajickova, D, Kral, M, Krejci, V, Pavlik, O, Peisker, T, Pernicka, M, Peska, S, Rapantova, P, Reif, M, Rekova, P, Sanak, D, Sebejova, M, Skoda, O, Slonkova, J, Stetkarova, I, Tenora, D, Tumova, R, Vaclavik, D, Vasko, P, Veverka, T, Vitkova, E, Volna, J, Andersen, G, Christensen, H, Christensen, T, Damgaard, D, Iversen, H, Krarup Hansen, C, Kruuse, C, Martinussen, M, Modrau, B, Murtuzova, A, Ovesen, C, Papina, M, Svaneborg, N, Von Weitzel-Mudersbach, P, Curtze, S, Fanta, S, Huhtakangas, J, Keskinarkaus, I, Kivioja, R, Koivu, M, Korpela, J, Larjo, T, Linna, M, Marinkovic, I, Martinez-Majander, N, Nieminen, T, Nikkanen, M, Numminen, H, Ortiz, R, Österlund-Tauriala, E, Roine, R, Roine, S, Ruuskanen, J, Saarinen, J, Shulga, A, Sibolt, G, Tapanainen, A, Tapiola, T, Tiainen, M, Tomppo, L, Tumpula, O, Tuomainen, P, Tynkkynen, J, Vainikka, S, Valpas, J, Virta, J, Ylikallio, E, Ylikotila, P, Accassat, S, Aniculaesei, A, Baronnet, F, Bejot, Y, Bindila, D, Birchenall, J, Blanc-Labarre, C, Bodiguel, E, Bouly, S, Cabrejo, L, Calvet, D, Corlobe, A, Crozier, S, Delpont, B, Deltour, S, Diaconu, M, Domigo, V, Epinat, M, Ferreira, A, Fisselier, M, Garnier, P, Gimenez, L, Gueguen, A, Guidoux, C, Guillon, B, Guiraudg, V, Hervieu-Begue, M, Hobeanu, M, Khoumri, C, Lamy, C, Lauer, V, Le Bouc, R, Lecouturier, K, Leder, S, Leger, A, Macian-Montoro, F, Meseguer, E, Morar-Precup, D, Morvan, T, Morvan, E, Obadia, M, Osseby, G, Philippi, S, Pico, F, Quenardelle, V, Reiner, P, Rigual, R, Rosso, C, Sabben, C, Samson, Y, Sevin, M, Sibon, I, Thouvenot, E, Timsit, S, Touze, E, Turc, G, Vahedi, K, Varvat, J, Wacongne, A, Wolff, V, Yalo, B, Zinchenko, I, Bagelmann, H, Bardutzky, J, Barlinn, J, Bathe-Peters, R, Berrouschot, J, Dietzel, J, Ehrlich, S, Fatar, M, Filipov, A, Fluri, F, Gabriel, M, Geran, R, Gliem, M, Graf, S, Griebe, M, Grosse, G, Haeusler, K, Harmel, P, Held, V, Hellwig, S, Henkner, J, Hieber, M, Hoyer, C, Jander, S, Keilitz, J, Kellner, J, Knecht, S, Koch, M, Koehler, L, Kucken, D, Kusnick, G, Lambeck, J, Lee, J, Leisse, I, Lubke-Detring, S, Machetanz, J, Mensch, A, Meyer, N, Molis, A, Mueller, T, Muhl, C, Nave, A, Radtke, A, Roth, Y, Roukens, R, Schlachetzki, F, Schneider, I, Schuppner, R, Schurig, J, Schwarzbach, C, Seidel, G, Sonntag, N, Steinert, S, Stoll, A, Stumpp, A, Taggeselle, J, Trommer, A, Tuetuencue, S, Wartenberg, K, Weissenborn, K, Wittayer, M, Wolf, M, Wolter, C, Worthmann, H, Wunderlich, S, Zitzmann, A, Anagnostou, E, Brokalaki, C, Hatzitolios, A, Kakaletsis, N, Kanellos, I, Kei, A, Korompoki, E, Koutroubi, A, Liamis, G, Makaritsis, K, Manios, E, Michas, F, Milionis, H, Papadopoulos, G, Papadopoulou, E, Papagiannis, A, Polychronopoulou, E, Sagris, D, Satsoglou, S, Savopoulos, C, Solganov, I, Spengos, K, Stamatelopoulos, K, Terentiou, A, Tountopoulou, A, Vassilopoulou, S, Amjad, A, Balazs, A, Bankuti, Z, Bicsak, T, Borcsik, L, Csanyi, A, Csiba, L, Csontos, K, Csuha, R, Czurko, M, Danku, V, Dioszeghy, P, Faust, K, Fazekas, F, Gerocs, Z, Gottschal, M, Gyuker, N, Hajas, A, Horvath, L, Horvath, M, Iljicsov, A, Jakab, K, Javor, L, Kakuk, I, Karasz, O, Kasa, K, Kasza, J, Kerekgyarto, M, Klivenyi, P, Kovacs, K, Kovacs, T, Kovacs, H, Lajos, B, Lovasz, R, Magyar, T, Matoltsy, A, May, Z, Molnar, S, Monosi, C, Motko, T, Nemeth, R, Nemeth, L, Nikl, J, Olah, L, Orosz, V, Panczel, G, Pentek, S, Prendl, B, Rozsa, C, Rum, G, Sas, K, Sas, A, Semjen, J, Simony, Z, Sipos, I, Szabo, K, Szasz, G, Szegedi, N, Szekely, A, Szilagyi, G, Szoboszlai, K, Szpisjak, L, Toth, G, Uhrinyakova, L, Valikovics, A, Varga, Z, Vass, L, Vastagh, I, Vecsei, L, Zboznovits, D, Coveney, S, Horgan, G, Kelly, P, Murphy, S, Smyth, A, Waters, R, Abu Ahmad, F, Bloch, S, Dorodnicov, E, Hallevi, H, Haratz, S, Horev, A, Kolianov, V, Leker, R, Mahagney, A, Marzelik, O, Rephaeli, G, Tanne, D, Weller, B, Acciarresi, M, Adami, A, Agostoni, E, Alemseged, F, Altavilla, R, Angelocola, S, Anticoli, S, Berardi, V, Bravi, M, Candeloro, E, Cappellari, M, Carletti, M, Caruso, P, Castellini, P, Cavallini, A, Cenciarelli, S, Cerrone, P, Condurso, R, Consoli, D, Danese, A, Della Marca, G, Denaro, M, Di Mascio, M, Diomedi, M, Distefano, M, Frisullo, G, Furlanis, G, Galati, F, Gallina, A, Gallinella, E, Giannandrea, D, Giatsidis, F, Greco, L, Impellizzeri, M, Landolfi, A, Lanfranconi, S, Latte, L, Lembo, G, Longoni, M, Marando, C, Marini, C, Marsili, E, Mastrocola, S, Mazzoli, T, Melis, M, Micheletti, N, Moller, J, Monzani, V, Naccarato, M, Paciaroni, M, Padiglioni, C, Persico, A, Pezzella, F, Pieroni, A, Piras, V, Postorino, P, Pozzerese, C, Profice, P, Ricci, S, Rinaldi, C, Rizzato, B, Rocco, A, Roveri, L, Santalucia, P, Semerano, A, Sicilia, I, Silvestrini, M, Sucapane, P, Tomelleri, G, Tropepi, D, Venti, M, Amino, T, Chin, M, Deguchi, I, Fujigasaki, H, Fukuyama, K, Haraguchi, K, Hasegawa, Y, Hattori, M, Hayashi, T, Hirose, M, Honma, Y, Igarashi, S, Irie, S, Itabashi, R, Ito, Y, Kamata, T, Kaneko, C, Kawanishi, M, Kimura, R, Kitagawa, K, Kobayashi, Y, Kondo, T, Kuwashiro, T, Matsumoto, S, Miyake, H, Nagakane, Y, Nishino, S, Nishiyama, Y, Nogawa, S, Ochiai, J, Ohira, M, Okamoto, Y, Okubo, S, Okuda, S, Ooyama, K, Sakai, N, Suenaga, T, Suzuki, H, Takamatsu, K, Takao, M, Taki, W, Takizawa, S, Tokunaga, K, Toyoda, K, Urui, S, Yamada, T, Yamasaki, M, Yoshida, Y, Yuasa, H, Bae, H, Cha, J, Chang, D, Chung, C, Heo, J, Hong, K, Kim, J, Lee, B, Nah, H, Oh, K, Park, M, Park, J, Rha, J, Sohn, S, Amaya Sanchez, L, Arauz Gongora, A, Cantu Brito, C, Chiquete Anaya, E, Felipe Amaya, P, Fernandez Vera, J, Garcia Lopez, R, Gien Lopez, J, Gongora-Rivera, J, Hernandez, J, Leal Cantu, R, Lopez Garza, N, Medina Pech, C, Mendez, B, Pena Sedna, L, Reyes Morales, S, Ruiz Franco, A, Serrano, F, Tovar, M, Uribe, R, Bak, Z, Baranowska, A, Bilik, M, Blazejewska-Hyzorek, B, Brola, W, Brzoska-Mizgalska, J, Buksinska-Lisik, M, Chorazy, M, Czerska, M, Czuryszkiewicz, M, Dalek, G, Dylewicz, L, Fiszer, U, Fraczek, A, Friedman, A, Fryze, W, Gasecki, D, Gębura, K, Geremek, M, Glabinski, A, Gluszkiewicz, M, Goździk, I, Grzesik, M, Jasek, L, Kaczorowska, B, Kalinowska, K, Kaminska, K, Kapica-Topczewska, K, Karlinski, M, Kobayashi, A, Kosarz-Lanczek, K, Kowalczyk, K, Kowalska, M, Kraska, J, Krzyzanowska, M, Kulakowska, A, Kurkowska-Jastrzebska, I, Lasek-Bal, A, Litwin, T, Morton, M, Myśliwy, W, Nosek, K, Nowak, B, Nowakowska-Śledź, E, Odyniec, A, Oleszek, J, Ozdoba-Rot, J, Palasik, W, Pawelczyk, M, Rozanski, D, Rozniecki, J, Sawicka, M, Sieczkowska, E, Skowron, P, Skowronska, M, Sliwinska, B, Sobolewski, P, Sobota, A, Stoiński, J, Szczuchniak, W, Szczyrba, S, Szewczyk, Z, Szlufik, S, Tarasiuk, J, Tutaj, A, Uchwat, U, Wach-Klink, A, Winska-Tereszkiewicz, A, Wisniewska, A, Włodek, A, Wojnarowska-Arendt, A, Zalewska, J, Zielinska-Turek, J, Ziomek, M, Zwiernik, J, Abreu, P, E Silva A, Amaral, Azevedo, E, Barroso, C, Calejo, M, Campillo, J, Campos Costa, E, Coelho, J, Correia, M, Correia, C, Gregorio, T, Lopes, D, Machado, C, Mendonca, T, Pereira, L, Pidal, A, Pineiro, S, Pinto, A, Ribeiro, J, Rodrigues, M, Salgado, P, Salgado, A, Santo, G, Sargento, J, Varela, R, Abroskina, M, Badalyan, K, Balueva, T, Barulin, A, Bazhenova, O, Belkin, A, Bogdanov, E, Daineko, A, Druzenko, I, Fedin, A, Fidler, M, Gogoleva, E, Golikov, K, Gonysheva, Y, Greshnova, I, Guryanova, N, Gusev, V, Kashaeva, E, Kaygorodtseva, S, Khairutdinova, D, Kholopov, M, Kirpicheva, S, Koltsov, I, Konkov, I, Kurenkova, N, Kurtenkova, N, Kurushina, O, Kustova, M, Lagutenko, M, Lenskaya, L, Lupinogina, L, Lvova, A, Melnikova, E, Meshkova, K, Morozova, E, Mozhejko, E, Nikoforova, M, Obrezan, A, Ondar, V, Pizova, N, Polyakov, A, Popov, D, Prazdnichkova, E, Prokopenko, S, Pudov, E, Salnikov, M, Samoshkina, O, Semushina, D, Shchukin, I, Shepeleva, E, Shmonin, A, Smolkin, A, Soldatov, M, Soloveva, L, Solovyeva, E, Stakhovskaya, L, Tcvetkova, S, Varvyanskaya, N, Voznyuk, I, Zhirnova, O, Ahmed, F, Basson, M, Engelbrecht, J, Hobson, B, Jansen, J, Nel, J, Nell, H, Njovane, X, Pretorius, M, Roos, J, Salig, S, Siebert, M, Amaro, S, Arenillas Lara, J, Arias Rivas, S, Baez Martinez, E, Bas, M, Bashir, S, Bragado, I, Cajaraville, S, Camps, P, Cardona Portela, P, Casado-Naranjo, I, Castellanos, M, Cayuela Caudevilla, N, Chamorro, A, Constantino Silva, A, Cortijo Garcia, E, De La Torre, J, De Torres, R, Diaz Otero, F, Diez-Tejedor, E, Escribano, B, Escudero, I, Fernandez, M, Font, M, Fortea, G, Freijo, M, Fuentes Gimeno, B, Gamero, M, Garcia, J, Garcia Pastor, A, Garcia Sanchez, S, Geniz Clavijo, M, Gil Nunez, A, Giralt, E, Gomez-Choco, M, Gomis, M, Gutiérrez, R, Iglesias Mohedano, A, Lago, A, Lara Lezama, L, Lara Rodriguez, B, Llull, L, Lopez Fernandez, M, Lorenzo, A, Maestre-Moreno, J, Marta Moreno, J, Marti-Fabregas, J, Martínez Sánchez, P, Mauri Cabdevila, G, Mengual Chirifie, J, Molina, C, Molina, J, Moniche, F, Morales, L, Morales, A, Nombela, F, Núñez, F, Pagola, J, Perez, S, Portilla, J, Prats, L, Purroy, F, Quesada Garcia, H, Ramirez Moreno, J, Redondo Robles, L, Renu, A, Riveira Rodriguez, C, Roa, A, Rodriguez Campello, A, Rodriguez Pardo De Donlebun, J, Rodriguez Yanez, M, Rudilosso, S, Ruiz Ares, G, Sànchez Cerón, M, Santamaria Cadavid, M, Sanz Cuesta, B, Serena, J, Silva, Y, Soriano Soriano, C, Tejada Garcia, J, Tejada Meza, H, Tembl, J, Terceno, M, Trillo, S, Urra, X, Usero Ruiz, M, Vazquez, P, Vilar, C, Villanueva Osorio, J, Ximenez-Carrillo, A, Zapata, E, Esbjornsson, M, Karlsson, J, Kremer, C, Kuris, A, Staaf, G, Stiehm, M, Timberg, I, Tossavainen, C, Wester, P, Arnold, M, Baumgartner, P, Beer, J, Bicker, H, Boos, L, Cereda, C, Chaloulos-Iakovidis, P, Christian, L, Engelter, S, Fisch, L, Fischer, U, Frey, S, Frick, M, Hauk, M, Hoffmann, M, Kahles, T, Manno, C, Medlin, F, Mircea, D, Nedeltchev, K, Panos, L, Polymeris, A, Schillinger, N, Stocker, R, Sztajzel, R, Alaydin, H, Batur Caglayan, H, Colakoglu, S, Demirci, N, Duman, T, Eren, F, Gokce, M, Inanc, Y, Nazliel, B, Ongun, G, Ozcekic Demirhan, S, Ozyurt, E, Selcuk, D, Sorgun, M, Tezcan, S, Togay Isikay, C, Tokgoz, O, Ulku Acar, R, Uluduz Ugurlu, D, Abdul-Saheb, M, Ahmad, N, Ali, A, Alwis, L, Balogun, I, Bathula, R, Behnam, Y, Bhandari, M, Bhargavah, M, Black, T, Blank, C, Bruce, D, Burn, M, Canepa, C, Chakrabarti, A, Chandrasena, D, Chembala, J, Cheripelli, B, Clarke, R, Cohen, D, Collas, D, Constantin, C, Dani, K, Del Giudice, A, Dennis, M, Devine, J, Dima, S, Doubal, F, Duodu, Y, Dutta, D, El Ta Wil, S, Elyas, S, Evans, N, Eveson, D, Fotherby, K, France, E, Furnace, J, Grabowski, S, Gunathilagan, G, Gutierrez, R, Guyler, P, Hargroves, D, Harkness, K, Harvey, M, Hayhoe, H, Hicken, L, Hussain, M, Kelly, S, Lam, M, Lindert, R, Louw, S, Luder, R, Macleod, M, Majid, A, Mangion, D, Markova, S, Markus, H, Marsh, R, Mcarthur, K, Menon, N, Metcalf, K, Minhas, J, Minns, M, Mistri, A, Moreton, F, Mpelembue, M, Muddegowda, G, Mudhar, O, Musarrat, K, Myint, M, Natarajan, I, Naylor, D, Ngeh, J, Papavasileiou, V, Perry, R, Piechowski-Jozwiak, B, Pradhan, M, Rani, A, Rashed, K, Robinson, T, Roffe, C, Saksena, R, Sattar, N, Sekaran, L, Selvarajah, J, Shah, S, Sinha, D, Sivakumar, R, Sztriha, L, Walters, D, Webb, T, Werring, D, Whiteley, W, Whiting, R, Abdelhamid, N, Abdul Rahman, D, Amin, H, Androulakis, M, Babikian, V, Baker, M, Barker Trejo, S, Benjamin, A, Birnbaum, L, Burke, J, Chen, S, Clark, W, Coull, B, De Havenon, A, Dearborn, J, Degeorgia, M, Essa, B, Fares, M, Favate, A, Furlan, A, Gebreyohanns, M, Goddeau, R, Green, D, Greer, D, Haralur Sreekantaiah, Y, Hasan, R, Hedna, V, Henninger, N, Holmstedt, C, Ishida, K, Jagolino, A, Johnson, M, Jun-Oconnell, A, Kaur, S, Khanna, A, Kirshner, H, Kittner, S, Kleindorfer, D, Leira, E, Loomis, C, Lord, A, Lowenkopf, T, Lutsep, H, Magadan, A, Majjhoo, A, Maud, A, Mayasi, Y, Mccullough, L, Mckinney, J, Mehta, S, Mehta, D, Mehta, B, Messe, S, Miller, B, Milling, T, Moonis, M, Navaratnam, D, Okpala, M, Patel, N, Pettigrew, L, Phinney, T, Ramos-Estebanez, C, Rasmussen, J, Rodriguez, G, Rybinnik, I, Santiago, P, Sarraj, A, Savitz, S, Sawyer, R, Scandura, T, Schindler, J, Sen, S, Shang, T, Sharrief, A, Sila, C, Simpkins, A, Sundararajan, S, Talahma, M, Tayal, A, Thaler, D, Tirschwell, D, Torres, J, Vora, N, Warnack, W, Waters, M, Wilson, C, Xiong, W, Zweifler, R, Zanferrari, C., St Marys Development Trust, Servicio de Neurologia (SANTIAGO - Neurologie), Universidad del Desarrollo, Department of Neurology (Dep Neuro - BEIJING), Tiantan Hospital, Neurology department, Universidade de Coimbra [Coimbra], Department of Internal Medicine, University Hospital Basel [Basel], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Neurological Sciences, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Department of Neurology, Seoul National University Hospital, Institute of Neurosciences and Psychology [Glasgow], University of Glasgow, Neurology Department, Ichilov Medical Center, CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Yperzeele, Laetitia, NAVIGATE ESUS Investigators, and Selçuk Üniversitesi

Subjects
Stroke/etiology, Male, [SDV]Life Sciences [q-bio], Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Brain Ischemia, Brain ischemia, 0302 clinical medicine, DESIGN, Rivaroxaban, Hemorrhage/chemically induced, Secondary Prevention, Medicine, Factor Xa Inhibitors/adverse effects, Stroke, Rivaroxaban/adverse effects, ComputingMilieux_MISCELLANEOUS, 11 Medical and Health Sciences, Aspirin, Atrial fibrillation, General Medicine, FORAMEN OVALE CLOSURE, Middle Aged, TRIALS, Intracranial Embolism, SAFETY, Aged, Factor Xa Inhibitors, Female, Hemorrhage, Humans, Platelet Aggregation Inhibitors, Medicine (all), Cardiology, Foramen ovale closure, Platelet aggregation inhibitor, Settore MED/26 - Neurologia, Life Sciences & Biomedicine, medicine.drug, medicine.medical_specialty, Platelet Aggregation Inhibitors/adverse effects, ANTITHROMBOTIC THERAPY, Aspirin/adverse effects, WARFARIN, 03 medical and health sciences, Secondary Prevention/methods, Medicine, General & Internal, Internal medicine, Intracranial Embolism/drug therapy, General & Internal Medicine, NAVIGATE ESUS Investigators, METAANALYSIS, Science & Technology, CRYPTOGENIC STROKE, business.industry, Warfarin, medicine.disease, EFFICACY, ATRIAL-FIBRILLATION, Human medicine, business, Brain Ischemia/prevention & control, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

WOS: 000434263000007, PubMed: 29766772, BACKGROUND Embolic strokes of undetermined source represent 20% of ischemic strokes and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, may result in a lower risk of recurrent stroke than aspirin. METHODS We compared the efficacy and safety of rivaroxaban (at a daily dose of 15 mg) with aspirin (at a daily dose of 100 mg) for the prevention of recurrent stroke in patients with recent ischemic stroke that was presumed to be from cerebral embolism but without arterial stenosis, lacune, or an identified cardioembolic source. The primary efficacy outcome was the first recurrence of ischemic or hemorrhagic stroke or systemic embolism in a time-to-event analysis; the primary safety outcome was the rate of major bleeding. RESULTS A total of 7213 participants were enrolled at 459 sites; 3609 patients were randomly assigned to receive rivaroxaban and 3604 to receive aspirin. Patients had been followed for a median of 11 months when the trial was terminated early because of a lack of benefit with regard to stroke risk and because of bleeding associated with rivaroxaban. The primary efficacy outcome occurred in 172 patients in the rivaroxaban group (annualized rate, 5.1%) and in 160 in the aspirin group (annualized rate, 4.8%) (hazard ratio, 1.07; 95% confidence interval [CI], 0.87 to 1.33; P=0.52). Recurrent ischemic stroke occurred in 158 patients in the rivaroxaban group (annualized rate, 4.7%) and in 156 in the aspirin group (annualized rate, 4.7%). Major bleeding occurred in 62 patients in the rivaroxaban group (annualized rate, 1.8%) and in 23 in the aspirin group (annualized rate, 0.7%) (hazard ratio, 2.72; 95% CI, 1.68 to 4.39; P, BayerBayer AG; Janssen Research and Development, Supported by Bayer and Janssen Research and Development.

Published
2018
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72. Optical and morphological properties of poly(vinyl chloride)-nano-chitosan composites doped with TiO2and Cr2O3nanoparticles and their potential for solar energy applications

Author

Abed, Rasheed N., Sattar, Muhammed Abdul, Hameed, Seenar S., Ahmed, Dina S., Al-Baidhani, Mohammed, Kadhom, Mohammed, Jawad, Ali H., Zainulabdeen, Khalid, Al-Mashhadani, Mohammed H., Rashad, Alaa A., and Yousif, Emad

Abstract

In the present work, the poly(vinyl chloride) (PVC)-nano-chitosan thin films were prepared, and the influence of filling Cr2O3and TiO2nanoparticles on the lattice was investigated. PVC and nano-chitosan (15 wt.%) were dissolved in tetrahydrofuran (THF) to ultimately form thin films by the casting method. The thin films' optical properties were characterized via a diffusive reflectance device within an approximate wavelength range of 250 to 1300 nm. Furthermore, the transmittance, reflectance, refractive index, absorption, optical conductivity, skin depth, dielectric constant, and Urbach energy were computed. The absorbance values of plain and NPs-filled thin films ranged between 92 and 99%. Also, the energy gap of films filled with NPs was reduced in the direct transmission from 3.9 to 2.9 eV and in the indirect transition from 3.0 to 2.55 eV. However, similar behavior for the Urbach energy was observed. The Fourier-transform infrared (FTIR) spectroscopy was used to study the interaction between the PVC and nano-chitosan as a new polymer composite. The X-ray powder diffraction (XRD) test showed a crystalline structure of the thin films, while the microscopic and atomic force microscopy (AFM) images demonstrated a good dispersion of nano-chitosan and NPs within the PVC lattice. The synthesized films could be good candidates for optoelectronics, glass processing, and ceramic production applications.

Published
2022
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73. Simultaneous quantitative determination of seven novel tyrosine kinase inhibitors in plasma by a validated UPLC-MS/MS method and its application to human microsomal metabolic stability study

Author

Essam Ezzeldin, Rasheed N. Herqash, Toqa El-Nahhas, and Muzaffar Iqbal

Subjects
Electrospray ionization, Clinical Biochemistry, Ethyl acetate, 030226 pharmacology & pharmacy, 01 natural sciences, Biochemistry, High-performance liquid chromatography, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Limit of Detection, Tandem Mass Spectrometry, Liquid chromatography–mass spectrometry, Microsomes, Enzyme Stability, medicine, Humans, Sample preparation, Protein Kinase Inhibitors, Chromatography, High Pressure Liquid, Chromatography, medicine.diagnostic_test, Elution, 010401 analytical chemistry, Selected reaction monitoring, Reproducibility of Results, Cell Biology, General Medicine, Protein-Tyrosine Kinases, 0104 chemical sciences, chemistry, Therapeutic drug monitoring, Linear Models
Abstract

A rapid, sensitive and reproducible ultra-high performance liquid chromatography mass spectrometry method was developed and validated for simultaneous determination of seven tyrosine kinase inhibitors (dasatinib, foretinib, osimertinib, gefitinib, ibrutinib, linifanib and motesanib) in human plasma samples using quizartinib as internal standard (IS). The sample preparation was performed by liquid-liquid extraction method, using a mixture of ethyl acetate and tert butyl methyl ether (50:50, v/v) as extracting solvents. Chromatographic separation was achieved using acquity UPLC BEH C18, 1.7 µm 2.1 × 100 mm column and a mobile phase consisting of a mixture of acetonitrile (0.1% formic acid) and 20 mM ammonium acetate (95:5) at a flow rate of 0.25 mL/min. All the analytes and IS were eluted within 2 min, with total run time of 3 min only. The electrospray ionization in positive mode was used and all analytes were monitored using multiple reaction monitoring (MRM) mode. The method was linear and reproducible for all the compounds in the range of 5–1000 ng/mL. Between- and within-run accuracy ranged from 86.7% to 92.5%, and the precision was less than 11.9% for all seven compounds. The developed method was successfully applied to in-vitro human microsomal metabolic stability study. This method could be useful in clinical application for therapeutic drug monitoring (TDM) of these analytes and for individualization of therapeutic regimens.

Published
2020
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74. Spectrally selective coating of nanoparticles (Co3O4:Cr2O3) incorporated in carbon to captivate solar energy.

Author

Abed, Rasheed N., Abdallh, Mustafa, Adnan Rashad, Alaa, Al‐Mohammedawi, Haidar Ch., and Yousif, Emad

Subjects
*SOLAR energy, *SOLAR radiation, *THIN films, *BAND gaps, *SURFACE coatings
Abstract

Innovatory nanocomposite comprising nanomaterials Co3O4:Cr2O3 and carbon (fuel ash) was designed to absorb solar energy. Different concentration ratios of Co3O4 and Cr2O3 nanoparticles were utilized as a dopant for fuel thin films synthesis via spin and casting methods on glass and aluminum substrates. The optical properties of the modified films demonstrated in the range of 250 to 1300 nm. The data were interpreted in terms of a phonon‐assisted theory. Energy gap (Eg) of doped C was calculated with different concentration ratios of Co3O4:Cr2O3 (0.5:2.5, 1:2, 1.5:1.5, 2:1, 2.5:0.5) wt%, and fixed concentration of C in 7wt%. The results showed Eg of the doped samples in the range of 2.9 to 3.9 eV. In addition, the intensity of the solar radiation was measured. The absorptivity was in the range of 88 to 93.6%. The above results are comparable to those of semiconductors and have high absorptivity values when the nanocomposite was utilized on a flat plate collector as a coating to trap and absorb solar energy. [ABSTRACT FROM AUTHOR]

Published
2020
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76. Restraint stress-induced central monoaminergic & oxidative changes in rats & their prevention by novel Ocimum sanctum compounds

Author

AUSAF AHMAD, Rasheed, N., Chand, K., Maurya, R., Banu, N., and Palit, G.

Subjects
Male, Serotonin, Plant Extracts, Dopamine, Hippocampus, Antioxidants, Corpus Striatum, Frontal Lobe, Rats, Rats, Sprague-Dawley, Norepinephrine, Oxidative Stress, Ocimum, Stress, Physiological, Ocimum sanctum, noradrenaline, Animals, Original Article, restraint stress, Lipid Peroxidation, Antioxidant system
Abstract

Background & objectives: Ocimum sanctum (OS) is known to possess various therapeutic properties. We have earlier isolated and characterized three OS compounds; Ocimarin, Ocimumoside A and Ocimumoside B. However, their role in modulating stress-induced central changes is unexplored. Thus, the present study was aimed to investigate the effect of these OS compounds on restraint stress (RS)-induced changes in the monoaminergic and antioxidant systems in the frontal cortex, striatum and hippocampus of rats. Methods: RS was produced by immobilizing (restraining) the Sprague Dawley rats for a period of 2.5 h inside cylindrical steel tubes. The monoamine levels and the in vivo antioxidant status in brain regions were evaluated by HPLC-EC and spectrophotometric assays, respectively. Results: RS significantly increased the dopamine levels in the frontal cortex and decreased in the striatum and hippocampus, and accompanied with selective increase of dopamine metabolites compared to the NS control group. The serotonin and its metabolite levels were significantly increased, while noradrenaline levels were decreased by RS in the three brain regions studied. The activities of superoxide dismutase and glutathione peroxidase in the frontal cortex and striatum were significantly increased by RS with decreased glutathione levels and increased lipid peroxidation. Pre-treatment with Ocimumoside A and B (40 mg/kg po) for a period of 3 days prevented the RS-induced changes with an efficacy similar to that of standard anti-stress (Panax quinquefolium; 100 mg/kg po) and antioxidant (Melatonin; 20 mg/kg ip) drugs, while, Ocimarin failed to modulate these changes. OS compounds per se had no effect on these parameters. Interpretation & conclusions: The present findings showed the anti-stress potential of Ocimumoside A and B in relation to their simultaneous modulatory effects on the central monoaminergic and antioxidant systems implicating their therapeutic importance in stress-related disorders. Further studies are required to understand the mechanism of action of these compounds.

Published
2012

80. Amelioration of Insulin, Leptin and Adiponectin Levels in Experimental Metabolic Syndrome Model by Some Drugs.

Author

AL-RASHEED, N. M., ABDELKAREM, H. M., FADDA, L. M., MOHAMED, A. M., BASSIOUNI, Y., ALI, H. M., and GAFEER, A. H.

Subjects
*INSULIN, *HYPOGLYCEMIC agents, *METFORMIN, *METABOLIC syndrome, *ATORVASTATIN, *ORLISTAT
Abstract

A comparative study was planned to explore the modulating impact of metformin, Lipitor or orlistat against the metabolic syndrome components, including hyperglycemia and hyperlipidemia. Also, the effects of these drugs on leptin and adiponectin as biomarkers of metabolic syndrome in a rat model were investigated for the first time. The administration of these drugs each alone to metabolic syndrome induced rats markedly ameliorated the increase in blood glucose, normalized the serum insulin and the high-density lipoprotein cholesterol levels and reduced triglyceride, total cholesterol and low-density lipoprotein cholesterol. The alterations in serum leptin and adiponectin levels in metabolic syndrome induced rats were significantly modulated by these drugs. Metformin was the most effective drug in modulating most of the studied parameters. [ABSTRACT FROM AUTHOR]

Published
2016
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81. ASSOCIATION OF SERUM URIC ACID WITH LEVEL OF BLOOD PRESSURE IN TYPE 2 DIABETIC PATIENTS.

Author

RASHEED, N., AMIN, N., and GHAZNAVI, S.

Subjects
*URIC acid, *DIABETES risk factors, *KIDNEY failure, *HEMOGLOBIN polymorphisms, *CREATININE, *THERAPEUTICS
Abstract

Background and Objectives: Diabetes mellitus (DM) is a chronic disease characterized by insulin deficiency or peripheral resistance resulting in hyperglycemia. Hyperuricemia has been reported with increased risk of renal insufficiency. The objective of the study was to determine the association of uric acid with blood pressure in type 2 diabetic patients. Methods: In this study eighty patients with type 2 diabetes mellitus were included. No patient had history of gout or history of using antihypertensive or uric acid lowering drugs. HbA1c was performed on Hemoglobin - Testing System (D-10-Biored Laboratories). Serum uric acid (UA), serum creatinine and plasma glucose were measured on fully automated chemistry analyzer (Metrolab - 2300). Results: The study population consisted of 80 subjects, among them 32 (40%) were male and 48 (60%) were female. Among 80 subjects, the age limit started from 50 years to 68 years with mean of 58.16 ±. Mean HbA1c level was 7.63 ± 1.6, mean uric acid level 5.86 ± 0.97 and mean creatinine level was 0.86 ± 0.20. Mean systolic and diastolic blood pressure were 124 ± 11.78 and 82.50 ± 8.49 respectively. Uric acid levels are correlated with blood pressure (systolic and diastolic) in diabetic patients. Conclusion: The present study demonstrated a strong correlation between serum uric acid and systolic and diastolic blood pressure levels in type 2 diabetic patients. [ABSTRACT FROM AUTHOR]

Published
2016

85. Prophylactic role of α-lipoic acid and vitamin E against zinc oxide nanoparticles induced metabolic and immune disorders in rat's liver.

Author

AL-RASHEED, N. M., ABDEL BAKY, N. A., FADDAH, L. M., FATANI, A. J., HASAN, I. H., and MOHAMAD, R. A.

Abstract

OBJECTIVES: Potential health hazard is associated with the wide use of nanoparticles. The prophylactic role of either α- lipoic acid (α -lip) or vitamin E (vit E) against the toxic effect of zinc oxide nano-particles (ZnONPs) induced metabolic disorder, inflammation and DNA damage in rat livers was studied. MATERIALS AND METHODS: ZnO-NPs were administered orally using two doses (600 mg and 1 g/kg body weight/day for 5 consecutive days). Some biomarkers of tissue damage, metabolic disorder, and DNA damage were investigated to explore the protective mechanisms of α -lip or vit E against ZnO-NPs induced hepatotoxicity. RESULTS: Co-administration of either α -lip (200 mg/kg body weight) or vit E (100 mg/kg body weight) daily for three weeks to ZnO-NPs intoxicated rats, significantly down-modulated the marked increase in serum ALT (marker of liver damage) and also serum glucose level (marker of metabolic disorder) as well as the pro-inflammatory biomarkers including nitric oxide (NO), tumor necrosis factor-α (TNF- α), interleukin- 6 (IL-6), C-reactive protein (CRP), and immunoglobin G (IGg). Reduced glutathione level was decreased while caspase3 level was elevated in liver tissues of ZnO-NPs treated group compared with intoxicated one. Moreover histopathological examination of liver tissue supported the previous biochemical markers. Furthermore, ZnO-NPs induced hepatic oxidative DNA damage. CONCLUSIONS: Either α -lip or vit E proved to be hepatoprotective agents against ZnONPs toxicity because they ameliorated metabolic and immune disorders related to liver damage and modulated the previous measured parameters. [ABSTRACT FROM AUTHOR]

Published
2014

86. Implementation of total laboratory automation at a tertiary care hospital in Saudi Arabia: effect on turnaround time and cost efficiency

Author

Tracy Louise Ellison, Maha Alharbi, Morad Alkaf, Shamad Elimam, Mariam Alfaries, Randa Al Nounou, Rasheed Nasr, and Tarek Owaidah

Subjects
Medicine
Abstract

BACKGROUND: Total laboratory automation (TLA) is a relatively new way of improving the management of high volume clinical laboratories. TLA may reduce staff, reduce operating costs, decrease testing time and provide enhanced process control. OBJECTIVES: Establish a cost efficient TLA that is less labor intensive, improves productivity and reduces turnaround time (TAT). DESIGN: Implementation of TLA for random glucose and troponin-T as sentinel tests to compare change in TAT. SETTING: Tertiary hospital with high volume of laboratory tests. METHODS: Routine patient samples for random glucose and troponin-T were used to capture TAT. Information on staff grades and schedules before and after implementing the TLA, and cost of contracts to deliver the service were collected. MAIN OUTCOME MEASURES: TAT, cost efficiency, and reduction in labor. RESULTS: The consolidation of contracts resulted in a reduction of 28.8 million SAR in direct costs. Staffing cost was reduced by 1.14 million SAR with less senior staff required; there were reductions in staff at both senior and junior level. The overall TAT for all tests was reduced by 32% in 2016 (after TLA implementation) compared to 2012 (before TLA implementation). The median TAT for random glucose tests was reduced by 21% (to 55.7 minutes in 2016 from 70.1 minutes in 2012). Evidence of test optimization by exploring the impact of stat tests, auto-dilutions and reruns on the overall TAT of the TLA is shown by comparing troponin T TATs after reclassifying stat tests (in 2016) to routine (in 2017). At the 75th percentile, there was a 27% reduction in TAT when comparing August 2016 to March 2017 with a 19% reduction in median TAT. CONCLUSION: By moving from stat to routine assays, the TAT was reduced, which is counter-intuitive. The use of stat assays slowed down the performance of the TLA. A careful review of the mix of assays should be conducted to maximize performance and to ensure that the system delivers what is required. LIMITATIONS: Room for improvement by systematically analyzing and reviewing the impact of making minor changes that could have significant impact on TAT. CONFLICT OF INTEREST: None.

Published
2018
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88. Novel Ocimumoside A and B as anti-stress agents: Modulation of brain monoamines and antioxidant systems in chronic unpredictable stress model in rats.

Author

Ahmad A, Rasheed N, Gupta P, Singh S, Siripurapu KB, Ashraf GM, Kumar R, Chand K, Maurya R, Banu N, Al-Sheeha M, and Palit G

Abstract

Therapies targeting central stress mechanisms are fundamental for the development of successful treatment strategies. Ocimum sanctum (OS) is an Indian medicinal plant traditionally used for the treatment of various stress-related conditions. Previously, we have isolated and characterized three OS compounds; Ocimarin, Ocimumoside A and Ocimumoside B. However, their role in modulating chronic stress-induced central changes is unexplored. Thus, in the present study the efficacy of these OS compounds have been evaluated on the chronic unpredictable stress (CUS)-induced alterations in the monoaminergic and antioxidant systems in the frontal cortex, striatum and hippocampus, along with the changes in the plasma corticosterone levels. CUS (two different types of stressors daily for seven days) resulted in a significant elevation of plasma corticosterone level, which was reversed to control levels by pretreatment with Ocimumoside A and B (40mg/kg p.o.), while Ocimarin showed no effect. The levels of NA, DA and 5-HT were significantly decreased in all the three brain regions by CUS, with a selective increase of DA metabolites. A significant decrease in the glutathione (GSH) content, the activities of superoxide dismutase and catalase with a significant increase in the glutathione peroxidase activity and lipid peroxidation was observed in all the three regions of the brain by CUS. The OS compounds alone did not cause any significant change in the baseline values of these parameters. However, Ocimumoside A and B (40mg/kg body p.o.) attenuated these CUS-induced alterations with an efficacy similar to that of standard anti-stress (Panax quinquefolium; 100mg/kg p.o.) and antioxidant (Melatonin; 20mg/kg i.p.) drugs. While, Ocimarin failed to modulate these CUS-induced alterations. Therefore, this is the first report which identified the anti-stress activity of novel Ocimumoside A and B at the level of central monoamines and antioxidant properties, implicating their therapeutic importance in the prevention of stress-related disorders. [ABSTRACT FROM AUTHOR]

Published
2012

89. HPTLC Fingerprint Profile of Extracts from Gum, Bark and Leaf of Boswellia serrata Linn. in Different Solvents.

Author

Rasheed, N. M. A., Waheed, M. A., Mushtaq, Ahmad, Chakraborthy, Alokananda, Shamshad, A. K., and Arfin, S.

Subjects
*GUMS & resins, *BURSERACEAE, *PLANT extracts, *AYURVEDIC medicine, *ANTI-inflammatory agents, *ANALGESICS, *CHROMATOGRAPHIC analysis, *HIGH performance liquid chromatography, *SILICA gel, *QUALITY control
Abstract

Introduction: Boswellia serrata Linn. tree is commonly found in India. The therapeutic value of its gum (guggulu) has been known to possess good anti-inflammatory, anti-arthritic, anti-proliferative and analgesic activities. Oleo-gum resins from Boswellia species are used in traditional medicine in India and African countries for the treatment of a variety of diseases. Methods: Chromatographic techniques were used for separation of components from different extracts of plant parts. This study was planned to develop a fingerprint profile of drug extracts from different parts of Boswellia serrata Linn. i.e., bark, gum and leaf in different solvents such as petroleum ether, chloroform and water. Results: A high-performance thin layer chromatography (HPTLC) method for the separation of the active constituents in Boswellia serrata extracts has been developed and TLC of these extracts on silica gel precoated aluminium plates of Merck by automatic TLC applicator and using solvent gradient system was performed. Conclusion: The HPTLC method for routine quality control of present species can be carried out using this method for different extracts of plant parts and serve in standardization of the drug. [ABSTRACT FROM AUTHOR]

Published
2010
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90. HPTLC Finger Print Profile of Dried Fruit of Physalis alkekengi Linn.

Author

Rasheed, N. M. A., Shareef, M. A., Ahmad, Mushtaq, Gupta, V.C ., Arfin, Shamsul, and Shamshad, A. K.

Subjects
*MEDICINAL plants, *PHYSALIS, *SOLANACEAE, *HERBAL medicine, *DIURETICS, *ANTISEPTICS
Abstract

Dried fruit of Physalis alkekengi Linn. (Fam. Solanaceae) is called as Kaknaj in the Unani system of medicine and used as diuretic, antiseptic, corrective of liver and sedative. Standardization of this drug is the key factor in regulating the therapeutic efficacy. Organoleptic parameters are not enough in establishing the standards of herbal drugs. Instrumental analysis of herbal drugs, which gives a more concrete picture regarding the qualitative and quantitative aspects of bioactive molecules, is widely accepted in the quality assessment of herbal drugs. However, such work related to traditional herbal medicines is lacking or in infantile stage. In the present study, morphological and physicochemical parameters and HPTLC finger print studies of Physalis alkekengi have been carried out and the results provide referential information for standardization. [ABSTRACT FROM AUTHOR]

Published
2010
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92. Influence of Friction Stir Welding Rotation Speeds In dwell phase on the Temperature Distribution of AA6061-T6 Aluminum Alloy Weldment

Author

Rasheed Nema Abed

Subjects
Friction Stir Welding, FE Model, Temperature distribution, Technology
Abstract

Friction Stir welding (FSW) parameters, which play a vital principle, that impact on the mechanical, microstructural properties of the weldment because of the warmth produced by the contact between the instrument and work-piece, An AA6061-T6 aluminum composite plate with measurements (186*150*4) mm3 welded through various rotational paces 800, 1000, 1200 and 1450 rpm, the created heat measured through thermocouples embedded in study zones of the Weldment, a Finite Element model have been executed by utilizing ANSYS 12.1 bundle charges to ponder the temperature appropriation amid stay stage, the outcomes demonstrates a decent assention between the after effects of exploratory and hypothetical tests. The most extreme temperature measured at this condition was 0.71 from the liquefying temperature of the sample at a maximum rotational speed of (1450) r/min.

Published
2017

97. Homozygosity for the Mediterranean a-thalassemic deletion (hemoglobin Barts hydrops fetalis)

Author

Al-Allawi Nasir, Shamdeen Maida, and Rasheed Najeeb

Subjects
Medicine
Abstract

Hemoglobin Barts hydrops fetalis syndrome is the most severe and generally fatal clinical phenotype of α-thalassemia. We diagnosed a fetus at 23-weeks gestation with having hydrops fetalis, by ultrasound. At 32 weeks, intrauterine death was detected. Molecular studies revealed that the fetus had the hemoglobin Barts hydrops fetalis syndrome due to homozygosity for the Mediterranean α-thalassemia deletion. This clinical phenotype is generally rare in the Eastern Mediterranean, and this is the first report of this syndrome from Iraq. Techniques for molecular characterization became available only very recently in this country, in a diagnostic setting. Thus, the detection of further cases might be expected in future.

Published
2010

98. Investigation of Gamma Ray Shielding by Polymer Composites

Author

Husain, H S, Rasheed, N A, and, Naji, and Mahmood, B M

Abstract

The present work deals with the shielding properties of polymer composites using gamma ray emitted from (Cs-137), point source. Polymer composites with different Lead ratio (0, 50, and 70 wt. %) with different lead size (powder and shot ball) have been prepared. To clarify the difference in the spectrum absorption gamma rays through the process of exponential equations graphic representation of the count rate as a function of composite thickness. The incident and transmitted intensities were measured using gamma spectrometer Sodium Iodide with traces of Thallium Na I (Tl) scintillator detector connected to a multichannel analyzer using the (USC-30) program. The liner attenuation coefficient were obtain of the prepared samples through graphic representation of natural allegartm count rate as a function of the thickness of absorbent material the obtained data are presented in the form of gamma spectra behind the prepared samples. Linear attenuation coefficients (u) gamma ray were calculate .The results show that, the density of the composites was observed to increase with increase filler loading .The result shows a directly relationship, between the thickness of the absorbent material and liner attenuation confection. The linear attenuation coefficient of the composites was found to increase with increased filler content in the composites and the highest value was 0.277 cm[?]1 was found for 70 wt. % of lead powder. The results shows that, the composites prepared of good absorption for gamma low energy the displayed results indicated that the constructed materials showed good radiation protection properties.

Published
2018

99. Antioxidant flavonoid glycosides from Evolvulus alsinoides.

Author

Kumar M, Ahmad A, Rawat P, Khan MF, Rasheed N, Gupta P, Sathiamoorthy B, Bhatia G, Palit G, and Maurya R

Abstract

Oxidative damage is an established outcome of chronic stress. Thus, the present study was designed to investigate the modulatory role of ethanolic extract of Evolvulus alsinoides (EA) in terms of oxidative alterations at peripheral and central level in rats subjected to chronic unpredictable stress (CUS). CUS exposure for 7 days reduced Cu, Zn superoxide dismutase and catalase activity with increase in glutathione peroxidase activity and lipid peroxidation, while decrease in reduced glutathione level in blood plasma, frontal cortex and hippocampus regions of brain. Oral administration of EA extract at 200mg/kg p.o. normalized these stress induced oxidative alterations with an efficacy similar to that of melatonin. Further, EA extract was taken up for detailed chemical investigation. Two new flavonol-4'-glycoside, kaempferol 4'-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (3) and kaempferol 4'-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (5) were isolated, along with eight known compounds (1, 2, 4 and 6-10). The structures of new compounds were established by detailed spectroscopic studies, while known compounds were characterized by direct comparison of their reported NMR data. All these compounds were evaluated for their in vitro antioxidant activity. Compounds 3, 5, 9 and 10 at 100 and 200 microg/ml showed significant in vitro antioxidant activity. Therefore, EA may hold great potential in preventing clinical deterioration in stress induced oxidative load and related disorders. (c) 2009 Elsevier B.V. All rights reserved. [ABSTRACT FROM AUTHOR]

Published
2010
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100. An in vitro evaluation of anti-oxidant properties of novel nano-composite material containing titanium oxide, zinc oxide and green tea extract.

Author

Joseph S, Nallaswamy D, Rajeshkumar S, Dathan PC, Rasheed N, Tharani M, Jacob J, and Jose L

Subjects
In Vitro Techniques, Zinc Oxide pharmacology, Zinc Oxide chemistry, Titanium chemistry, Titanium pharmacology, Antioxidants pharmacology, Tea chemistry, Nanocomposites chemistry, Plant Extracts pharmacology, Plant Extracts chemistry
Abstract

Introduction: Green tea is a medicinal beverage extracted from the plant Camellia sinensis. Antioxidants that exist naturally can be extracted as pure compounds from their parent materials for nutraceutical and medicinal applications. The present study aims to assess the antioxidant activity of Zinc oxide-titanium dioxide nano-composites (ZnO-TiO2 NCs) containing green tea extract., Materials and Methods: The antioxidant activity was tested by Hydrogen Peroxide [H2O2] assay, Fluorescence recovery after photo-bleaching [FRAP] assay and 2, 2-diphenyl-1- picrylhydrazyl[DPPH] assay. All tests have shown very good results for the ZnO-TiO2 NCs., Results: In this study, we present a straightforward, ecofriendly alternative for producing non-toxic zinc oxide and titanium oxide nano-composite material. This study could make a valuable contribution and create new opportunities in the market such as biological and pharmaceutical applications., Conclusion: The in vitro tests concluded that the novel nanocomposite containing ZnO-TiO2 and green tea extract has good anti-oxidant properties and it is non-toxic to the biological systems.

Published
2025

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