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7,380 results on '"Rainer, Peter"'

71. Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Author

de Boer, Rudolf, Hulot, Jean-Sébastien, Tocchetti, Carlo, Aboumsallem, Joseph, Ameri, Pietro, Anker, Stefan, Bauersachs, Johann, Bertero, Edoardo, Coats, Andrew, Čelutkienė, Jelena, Chioncel, Ovidiu, Dodion, Pierre, Eschenhagen, Thomas, Farmakis, Dimitrios, Bayes-Genis, Antoni, Jäger, Dirk, Jankowska, Ewa, Kitsis, Richard, Konety, Suma, Larkin, James, Lehmann, Lorenz, Lenihan, Daniel, Maack, Christoph, Moslehi, Javid, Müller, Oliver, Nowak-Sliwinska, Patrycja, Piepoli, Massimo, Ponikowski, Piotr, Pudil, Radek, Rainer, Peter, Ruschitzka, Frank, Sawyer, Douglas, Seferovic, Petar, Suter, Thomas, Thum, Thomas, van der Meer, Peter, Van Laake, Linda, von Haehling, Stephan, Heymans, Stephane, Lyon, Alexander, and Backs, Johannes

Subjects
Angiogenesis, Cancer, Cardio-oncology, Cardiotoxicity, Clonal haematopoiesis, Extracellular matrix, Heart failure, Inflammation, Metabolism, Comorbidity, Heart Failure, Humans, Inflammation, Neoplasms, Risk Factors
Abstract

The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the initiation and progression of both HF and cancer. Under stress, malignant and cardiac cells change their metabolic preferences to survive, which makes these metabolic derangements a great basis to develop intersection strategies and therapies to combat both diseases. Furthermore, genetic predisposition and clonal haematopoiesis are common drivers for both conditions and they hold great clinical relevance in the context of personalized medicine. Additionally, altered angiogenesis is a common hallmark for failing hearts and tumours and represents a promising substrate to target in both diseases. Cardiac cells and malignant cells interact with their surrounding environment called stroma. This interaction mediates the progression of the two pathologies and understanding the structure and function of each stromal component may pave the way for innovative therapeutic strategies and improved outcomes in patients. The interdisciplinary collaboration between cardiologists and oncologists is essential to establish unified guidelines. To this aim, pre-clinical models that mimic the human situation, where both pathologies coexist, are needed to understand all the aspects of the bidirectional relationship between cancer and HF. Finally, adequately powered clinical studies, including patients from all ages, and men and women, with proper adjudication of both cancer and cardiovascular endpoints, are essential to accurately study these two pathologies at the same time.

Published
2020

76. Fabrizio Moro im Interview

Author

Meyer, Rainer-Peter, Moro, Fabrizio, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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78. Tamás Fekete im Interview

Author

Meyer, Rainer-Peter, Fekete, Tamás, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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79. Barbara Wirth im Interview

Author

Meyer, Rainer-Peter, Wirth, Barbara, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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80. Tomas Drobny im Interview

Author

Meyer, Rainer-Peter, Drobny, Tomas, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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81. Peter Freiburghaus im Interview

Author

Meyer, Rainer-Peter, Freiburghaus, Peter, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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82. Luzi Dubs im Interview

Author

Meyer, Rainer-Peter, Dubs, Luzi, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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83. Rico Wieser im Interview

Author

Meyer, Rainer-Peter, Wieser, Rico, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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84. Hans-Rudolf Meyer im Interview

Author

Meyer, Rainer-Peter, Meyer, Hans-Rudolf, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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85. Rafael Velasco im Interview

Author

Meyer, Rainer-Peter, Velasco, Rafael, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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86. Christoph Spormann im Interview

Author

Meyer, Rainer-Peter, Spormann, Christoph, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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87. Ralph Sheikh im Interview

Author

Meyer, Rainer-Peter, Sheikh, Ralph, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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88. Beat Simmen im Interview

Author

Meyer, Rainer-Peter, Simmen, Beat, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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89. Dietrich Schlenzka im Interview

Author

Meyer, Rainer-Peter, Schlenzka, Dietrich, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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90. Hans-Kaspar Schwyzer im Interview

Author

Meyer, Rainer-Peter, Schwyzer, Hans-Kaspar, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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91. Ueli Schwarzenbach im Interview

Author

Meyer, Rainer-Peter, Schwarzenbach, Ueli, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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92. Markus Scheibel im Interview

Author

Meyer, Rainer-Peter, Scheibel, Markus, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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93. Stephan Schindele im Interview

Author

Meyer, Rainer-Peter, Schindele, Stephan, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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94. Thomas Rutishauser im Interview

Author

Meyer, Rainer-Peter, Rutishauser, Thomas, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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95. Michael Ruf im Interview

Author

Meyer, Rainer-Peter, Ruf, Michael, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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96. Claudio Dora im Interview

Author

Meyer, Rainer-Peter, Dora, Claudio, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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97. Pascal Rippstein im Interview

Author

Meyer, Rainer-Peter, Rippstein, Pascal, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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98. Hannes Rüdiger im Interview

Author

Meyer, Rainer-Peter, Rüdiger, Hannes, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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99. Felix Rapp im Interview

Author

Meyer, Rainer-Peter, Rapp, Felix, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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100. Bodo Purbach im Interview

Author

Meyer, Rainer-Peter, Purbach, Bodo, Meyer, Rainer-Peter, editor, Brantschen, Bruno, editor, Jeszenszky, Dezsö J., editor, and Lütscher, Andreas, editor

Published
2021
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