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52. Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle

Author

Zulkipli, Masyitah, primary, Mahbub, Nuzum, additional, Fatima, Ayesha, additional, Wan-Lin, Stefanie Lim, additional, Khoo, Teng-Jin, additional, Mahboob, Tooba, additional, Rajagopal, Mogana, additional, Samudi, Chandramathi, additional, Kathirvalu, Gheetanjali, additional, Abdullah, Nor Hayati, additional, Pinho, Ana Rita, additional, Oliveira, Sonia M. R., additional, Pereira, Maria de Lourdes, additional, Rahmatullah, Mohammed, additional, Hasan, Anamul, additional, Paul, Alok K., additional, Butler, Mark S., additional, Nawaz, Muhammad, additional, Wilairatana, Polrat, additional, Nissapatorn, Veeranoot, additional, and Wiart, Christophe, additional

Published
2022
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53. Phytochemicals and Nano-Phytopharmaceuticals Use in Skin, Urogenital and Locomotor Disorders: Are We There?

Author

Rajagopal, Mogana, primary, Paul, Alok K., additional, Lee, Ming-Tatt, additional, Joykin, Anabelle Rose, additional, Por, Choo-Shiuan, additional, Mahboob, Tooba, additional, Salibay, Cristina C., additional, Torres, Mario S., additional, Guiang, Maria Melanie M., additional, Rahmatullah, Mohammed, additional, Jahan, Rownak, additional, Jannat, Khoshnur, additional, Wilairatana, Polrat, additional, de Lourdes Pereira, Maria, additional, Lim, Chooi Ling, additional, and Nissapatorn, Veeranoot, additional

Published
2022
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58. The Role of Medicinal and Aromatic Plants against Obesity and Arthritis: A Review

Author

Paul, Alok K., primary, Jahan, Rownak, additional, Paul, Anita, additional, Mahboob, Tooba, additional, Bondhon, Tohmina A., additional, Jannat, Khoshnur, additional, Hasan, Anamul, additional, Nissapatorn, Veeranoot, additional, Wilairatana, Polrat, additional, de Lourdes Pereira, Maria, additional, Wiart, Christophe, additional, and Rahmatullah, Mohammed, additional

Published
2022
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59. Does Oxidative Stress Management Help Alleviation of COVID-19 Symptoms in Patients Experiencing Diabetes?

Author

Paul, Alok K., primary, Hossain, Md K., additional, Mahboob, Tooba, additional, Nissapatorn, Veeranoot, additional, Wilairatana, Polrat, additional, Jahan, Rownak, additional, Jannat, Khoshnur, additional, Bondhon, Tohmina A., additional, Hasan, Anamul, additional, de Lourdes Pereira, Maria, additional, and Rahmatullah, Mohammed, additional

Published
2022
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60. Can Artemisia herba-alba Be Useful for Managing COVID-19 and Comorbidities?

Author

Hasan, Anamul, primary, Biswas, Partha, additional, Bondhon, Tohmina Afroze, additional, Jannat, Khoshnur, additional, Paul, Tridib K., additional, Paul, Alok K., additional, Jahan, Rownak, additional, Nissapatorn, Veeranoot, additional, Mahboob, Tooba, additional, Wilairatana, Polrat, additional, Hasan, Md Nazmul, additional, de Lourdes Pereira, Maria, additional, Wiart, Christophe, additional, and Rahmatullah, Mohammed, additional

Published
2022
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61. Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

Author

Lim, Chooi Ling, primary, Raju, Chandramathi S., additional, Mahboob, Tooba, additional, Kayesth, Sunil, additional, Gupta, Kamal K., additional, Jain, Gaurav Kumar, additional, Dhobi, Mahaveer, additional, Nawaz, Muhammad, additional, Wilairatana, Polrat, additional, de Lourdes Pereira, Maria, additional, Patra, Jayanta Kumar, additional, Paul, Alok K., additional, Rahmatullah, Mohammed, additional, and Nissapatorn, Veeranoot, additional

Published
2022
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62. Conserved Candidate Antigens and Nanoparticles to Develop Vaccine against Giardia intestinalis.

Author

Sangkanu, Suthinee, Paul, Alok K., Chuprom, Julalak, Mitsuwan, Watcharapong, Boonhok, Rachasak, de Lourdes Pereira, Maria, Oliveira, Sonia Marlene Rodrigues, Wilairatana, Polrat, Rahmatullah, Mohammed, Wiart, Christophe, Nawaz, Muhammad, Sin, Chea, Kayesth, Sunil, and Nissapatorn, Veeranoot

Subjects
GIARDIA lamblia, VACCINE development, CHILD mortality, LACTOSE intolerance, CRYPTOSPORIDIUM parvum, ANTIGENS, SHIGELLOSIS
Abstract

Giardia intestinalis (Giardia lambia, Giardia duodenalis) infections in humans may be asymptomatic or symptomatic and associated with diarrhea (without blood), abdominal cramps, bloating, flatulence, and weight loss. The protozoan Giardia is the third most common cause of diarrhea and death in children under five, preceded only by rotavirus and by Cryptosporidium parvum and C. hominis infections. Antimicrobial drugs, particularly 5-nitroimidazole (5-NIs), are used to treat giardiasis in humans. Immunologically naive or immunocompromised host are more vulnerable to Giardia infection, whereas a degree of resistance to this protozoan is present in humans living in endemic areas. This suggests that vaccination may be a potential and appropriate means to control this parasitic disease outbreak and protect the human population. This review discusses Giardia antigens related to vaccine development. Additionally, based on the latest development of nanoparticle technology, a combination of methods for future research and development is proposed for the design of the next generation of powerful immunogens and an effective vaccine against Giardia. [ABSTRACT FROM AUTHOR]

Published
2023
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64. Nanotechnology Applications of Flavonoids for Viral Diseases

Author

Jannat, Khoshnur, primary, Paul, Alok K., additional, Bondhon, Tohmina A., additional, Hasan, Anamul, additional, Nawaz, Muhammad, additional, Jahan, Rownak, additional, Mahboob, Tooba, additional, Nissapatorn, Veeranoot, additional, Wilairatana, Polrat, additional, Pereira, Maria de Lourdes, additional, and Rahmatullah, Mohammed, additional

Published
2021
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66. Screening of Potent Phytochemical Inhibitors Against SARS-CoV-2 Main Protease: An Integrative Computational Approach

Author

Mahmud, Shafi, primary, Hasan, Md. Robiul, additional, Biswas, Suvro, additional, Paul, Gobindo Kumar, additional, Afrose, Shamima, additional, Mita, Mohsana Akter, additional, Sultana Shimu, Mst. Sharmin, additional, Promi, Maria Meha, additional, Hani, Umme, additional, Rahamathulla, Mohamed, additional, Khan, Md. Arif, additional, Zaman, Shahriar, additional, Uddin, Md. Salah, additional, Rahmatullah, Mohammed, additional, Jahan, Rownak, additional, Alqahtani, Ali M., additional, Saleh, Md. Abu, additional, and Emran, Talha Bin, additional

Published
2021
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67. Zingiber officinale: Ayurvedic Uses of the Plant and In Silico Binding Studies of Selected Phytochemicals With Mpro of SARS-CoV-2

Author

Jahan, Rownak, primary, Paul, Alok K., additional, Bondhon, Tohmina A., additional, Hasan, Anamul, additional, Jannat, Khoshnur, additional, Mahboob, Tooba, additional, Nissapatorn, Veeranoot, additional, Pereira, Maria de L., additional, Wiart, Christophe, additional, Wilairatana, Polrat, additional, and Rahmatullah, Mohammed, additional

Published
2021
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68. Anti-Acanthamoeba activity of a semi-synthetic mangostin derivative and its ability in removal of Acanthamoeba triangularis WU19001 on contact lens.

Author

Julalak Chuprom, Suthinee Sangkanu, Watcharapong Mitsuwan, Rachasak Boonhok, Wilawan Mahabusarakam, Singh, L. Ravithej, Ekachai Dumkliang, Kritamorn Jitrangsri, Paul, Alok K., Sirirat Surinkaew, Polrat Wilairatana, Pereira, Maria de Lourdes, Rahmatullah, Mohammed, Wiart, Christophe, Rodrigues Oliveira, Sonia Marlene, and Veeranoot Nissapatorn

Subjects
ACANTHAMOEBA, CELL membrane formation, MANGOSTIN, MANGOSTEEN, DENTAL adhesives, CELL size
Abstract

Garcinia mangostana L., also known as the mangosteen tree, is a native medicinal plant in Southeast Asia having a wide variety of pharmacologically active compounds, including xanthonoid mangostin. In this study, we examined the pharmacological activities of the selected semi-synthetic mangostin derivative, namely, amoebicidal activity, encystation inhibition, excystation activity, and removal capacity of adhesive Acanthamoeba from the surface of contact lens (CL). Among the three derivatives, C1 exhibited promising anti-Acanthamoeba activity against Acanthamoeba triangularis WU19001 trophozoites and cysts. SEM images displayed morphological changes in Acanthamoeba trophozoites, including the loss of acanthopodia, pore formation in the cell membrane, and membrane damage. In addition, the treated cyst was shrunken and adopted an irregular flat cyst shape. Under a fluorescence microscope, acridine orange and propidium iodide (AO/PI) staining revealed C1 induced condensation of cytoplasm and chromatin with the loss of cell volume in the treated trophozoites, while calcofluor white staining demonstrated the leakage of cell wall in treated cysts, leading to cell death. Interestingly, at the concentration ranges in which C1 showed the anti-Acanthamoeba effects (IC50 values ranging from 0.035-0.056 mg/mL), they were not toxic to Vero cells. C1 displayed the highest inhibitory effect on A. triangularis encystation at 1/16×MIC value (0.004 mg/mL). While C1 demonstrated the excystation activity at 1/128×MIC value with a high rate of 89.47%. Furthermore, C1 exhibited the removal capacity of adhesive Acanthamoeba from the surface of CL comparable with commercial multipurpose solutions (MPSs). Based on the results obtained, C1 may be a promising lead agent to develop a therapeutic for the treatment of Acanthamoeba infections and disinfectant solutions for CL. [ABSTRACT FROM AUTHOR]

Published
2022
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71. Peganum harmala Extract Has Antiamoebic Activity to Acanthamoeba triangularis Trophozoites and Changes Expression of Autophagy-Related Genes

Author

Boonhok, Rachasak, primary, Sangkanu, Suthinee, additional, Chuprom, Julalak, additional, Srisuphanunt, Mayuna, additional, Norouzi, Roghayeh, additional, Siyadatpanah, Abolghasem, additional, Mirzaei, Farzaneh, additional, Mitsuwan, Watcharapong, additional, Wisessombat, Sueptrakool, additional, de Lourdes Pereira, Maria, additional, Rahmatullah, Mohammed, additional, Wilairatana, Polrat, additional, Wiart, Christophe, additional, Ling, Lim Chooi, additional, Dolma, Karma G., additional, and Nissapatorn, Veeranoot, additional

Published
2021
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74. Amoebicidal activity of Cassia angustifolia extract and its effect on Acanthamoeba triangularis autophagy-related gene expression at the transcriptional level

Author

Boonhok, Rachasak, primary, Sangkanu, Suthinee, additional, Norouzi, Roghayeh, additional, Siyadatpanah, Abolghasem, additional, Mirzaei, Farzaneh, additional, Mitsuwan, Watcharapong, additional, Charong, Nurdina, additional, Wisessombat, Sueptrakool, additional, Pereira, Maria de Lourdes, additional, Rahmatullah, Mohammed, additional, Wilairatana, Polrat, additional, Wiart, Christophe, additional, Tabo, Hazel Anne, additional, Dolma, Karma G., additional, and Nissapatorn, Veeranoot, additional

Published
2021
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82. Contributors

Author

Abate, C., Adeghate, Ernest, Afroze, Chowdhury Alfi, Ahmed, Md Nasir, Ahmed, Mohammed M., Anand, Rajsavi Singh, Armour, Mike, Askari, Vahid Reza, Azam, Md Nur Kabidul, Bahnson, Edward Moreira, Baradaran Rahimi, Vafa, Barr, Alasdair M., Boivin, Michael, Brown, Joshua, Budde, Henning, Camacho-Rivera, Marlene, Chen, Ye, Chesworth, Rose, Cheung, Chi Wai, Chmura, Stacey E., Christiansen, April L., Clark, Thomas M., Colabufo, N.A., Contino, M., Costi, Roberta, Crescioli, Giada, da Silva-Júnior, Rui Milton Patrício, del Río, Carmen, Di Santo, Roberto, Duffy, Bryan C., Dyck, Jason R.B., Echeverry, Carolina, Eurich, Dean T., Fagetti, Jimena, Feingold, Daniel, Feng, Hui, Fernández-Carballido, Ana, Feuerstein, Joseph D., Filho, Alberto Souza Sá, Firenzuoli, Fabio, Fraguas-Sánchez, Ana Isabel, Garcia-Cairasco, Norberto, García-Fuster, M. Julia, García-García, Fabio, Garg, Ayushi, Gengo, Fran M., Gliksberg, Or, Gómez-Nieto, Ricardo, González-Mariscal, Isabel, Götz, Marcus R, Gyamfi, Daniel, Hagerman, Randi, Hashiesh, Hebaallah Mamdouh, Hernandez-Ortega, Nicolas, Hesami, Mohsen, Imperatori, Claudio, Islam, Jessica Y., Jahan, Rownak, Jha, Niraj Kumar, Jiang, Jessica XR, Johnson, Devon, Jones, Andrew Maxwell Phineas, Judd, Christopher D., Karl, Tim, Kaur, Ramanpreet, Kaushal, Naveen, Khan, Maria, Kumar, Sanjay, Kumar, Ujendra, Laws, III, John Staton, Lazarini-Lopes, Willian, Lee, Cerina, Leonetti, F., Leszko, Magdalena, Li, Lingyun, Linher-Melville, Katja, Lo, Lindsay A., Lombardi, Niccolò, López, Dolores E., Lowin, Torsten, Lyzwinski, Lynnette Nathalie, MacCallum, Caroline A., Machado, Sergio, Madia, Valentina Noemi, Maggini, Valentina, Mattle, Anna G., McLemon, Erin, Mechoulam, Raphael, Mehmood, Ishrat, Memarzia, Arghavan, Müller-Vahl, Kirsten R., Muñoz, Eduardo, Murillo-Rodríguez, Eric, Muschett, Matthew, Musetti, Bruno, Ojha, Shreesh, Patel, Vinood B., Paul, Tridib K., Piasek, Adrianna Maria, Pistawka, Carly A., Preedy, Victor R., Purcell, Chad, Rahmatullah, Mohammed, Rajendram, Rajkumar, Ralyea, Jr., Christopher C., Raup-Konsavage, Wesley M., Reyes-Parada, Miguel, Rodriguez, Diane L., Rosenthal, Martha S., Sadek, Bassem, Saleh, Ruba A., Scorza, Cecilia, Sera, Leah, Servilha-Menezes, Gabriel, Sharma, Tanvi, Shirah, Bader H., Shrestha, Srijan, Sinclair, Justin, Singh, Gurmit, Singh, Sneha, Smid, Scott D., Snider-Adler, Melissa, Sobiepanek, Anna, Somvanshi, Rishi K., Stefanachi, A., Stevenson, Maximillian H., Szejko, Natalia, Tanco, Kimberson, Thomas, Shilu Deepa, Thomson, Leonor, Torres-Suárez, Ana Isabel, Torterolo, Pablo, Valverde, Olga, Vannacci, Alfredo, Viana-Torre, Gerardo, Vidot, Denise C., Vrana, Kent E., Winkler, Matthias, Wong, Stanley Sau-Ching, Yadollahpour, Ali, and Yamamoto, Tetsuya

Published
2023
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83. Contributors

Author

Abundo, Ian Cornelius S., Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Ahmed, Md. Nasir, Ajayi, Olulope Olufemi, Ajiboye, Modupe Doris, Allan, Robert Bellarmine Pari Vivian, Beley, Genelynne J., Bernolo, Leslie F., Brakad, Douglas Daison, Buhay, Mikhail Ness M., Capirig, Christian John, Chikeokwu, Ikenna, Chua-Lim, Lorayne Ann, Chukwube, Vincent Obisike, Dable-Tupas, Genevieve, Dadia, Diana M., Daei-Hasani, Behrokh, Dauda, Wadzani Palnam, De Guzman, Maureen B., Derecho, Cecile Melisse P., Diovu, Edith Obioma, Egbuna, Chukwuebuka, Ejaz, Rebia, Escalante-Llavore, Carmelita, Eyupoglu, Ozan Emre, Ezejiofor, Madu, Ezugwu, Christopher Obodike, Ghazanfar, Shakira, Ghosh, Ronesh, Ghoshal, Kakali, Ijabadeniyi, Oluwatosin Ademola, Inobeme, Abel, Jain, Vaibhav, Jena, Goutam Kumar, Kha, Wahab Ali, Khan, Johra, Lao-Polestico, Rhodora Rhea, Lim, Charisse Joy C., Lim, Ma. Victoria B., Lim, Peter Paul C., Mahankali, Muralii Krishna, Maheshwari, Keshav, Mariadoss, Catherine Angela, Mba, Theodora Chidinma, Michael, Moses, Naresh, Parwani Nishit, Navneet, Nayak, Chandan Kumar, Nnamani, Daniel Okwudili, Nwafor, Felix Ifeanyi, Obi, Patrick Ebele, Odoh, Uchenna Estella, Okonta, Eleje Oboma, Olaniyan, Olugbemi Tope, Onyegbulam, Chukwuma Micheal, Onyekere, Peculiar Feenna, Otero, Maria Catherine B., Palai, Santwana, Panigrahi, Kahnu Charan, Pathak, Akanksha, Pizarro, Renz Romerino M., Rahmatullah, Mohammed, Rasmi, Yousef, Ratta, Karanjit, Rebezov, Maksim, Roy, Moushami, Sankaralingam, Preethi, Segocio, Hannah Grace B., Shariati, Mohammad Ali, Shweta Murthy, K., Singh, Ajeet, Singh, Bikarma, Sivaraj, Ariharan, Stephen, Ajilore Bamidele, Suruthimeenakshi, Selvam, Talampas-Abundo, Myalin D., Tulika, Verma, Udodeme, Ogechukwu Helen, Ugwu, Patience Ngozi, Ulamarulama, Romina M., Uzor, Ginikachukwu, Valencia, Ernie Kharl A., Valeroso, Mae Anne C., Vergara, Amor S., Vergara, April Rose N., and Yasmin, Iqra

Published
2023
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84. Evaluation of Lens culinaris phytochemicals in binding to the 3C-like protease of SARS-CoV-2 – A molecular docking approach

Author

Hasan, Anamul, primary, Jahan, Rownak, additional, Jannat, Khoshnur, additional, Bondhon, Tohmina Afroze, additional, Hossan, Md Shahadat, additional, Mazumder, Snehali, additional, Fatima, Ayesha, additional, Pereira, Maria de Lourdes, additional, Wiart, Christophe, additional, Nissapatorn, Veeranoot, additional, and Rahmatullah, Mohammed, additional

Published
2020
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88. Synergistic Effect of Garcinia Mangostana Combined With Chlorhexidine on Acanthamoeba Triangularis Trophozoites and Cysts

Author

Sangkanu, Suthinee, primary, Mitsuwan, Watcharapong, additional, Mahabusarakam, Wilawan, additional, Jimoh, Tajudeen O., additional, Wilairatana, Polrat, additional, Girol, Ana Paula, additional, Verma, Ajoy K., additional, Pereira, Maria de Lourdes, additional, Rahmatullah, Mohammed, additional, Wiart, Christophe, additional, Siyadatpanah, Abolghasem, additional, and Nissapatorn, Veeranoot, additional

Published
2020
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91. A Silent Attacker SARS-CoV-2 - A Review

Author

Jannat, Khoshnur, primary, Nahar, Nusratun, additional, Hossan, Md Shahadat, additional, Bondhon, Tohmina Afroze, additional, Hasan, Anamul, additional, Paul, Anita, additional, Jahan, Rownak, additional, and Rahmatullah, Mohammed, additional

Published
2020
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93. An Analysis Based on Molecular Docking and Molecular Dynamics Simulation Study of Bromelain as Anti-SARS-CoV-2 Variants.

Author

Tallei, Trina Ekawati, Fatimawali, Yelnetty, Afriza, Idroes, Rinaldi, Kusumawaty, Diah, Emran, Talha Bin, Yesiloglu, Talha Zahid, Sippl, Wolfgang, Mahmud, Shafi, Alqahtani, Taha, Alqahtani, Ali M., Asiri, Saeed, Rahmatullah, Mohammed, Jahan, Rownak, Khan, Md. Arif, and Celik, Ismail

Subjects
MOLECULAR dynamics, BROMELIN, COVID-19, MOLECULAR docking, ANGIOTENSIN I, SARS-CoV-2, VIRAL proteins, ANGIOTENSIN converting enzyme
Abstract

The rapid spread of a novel coronavirus known as SARS-CoV-2 has compelled the entire world to seek ways to weaken this virus, prevent its spread and also eliminate it. However, no drug has been approved to treat COVID-19. Furthermore, the receptor-binding domain (RBD) on this viral spike protein, as well as several other important parts of this virus, have recently undergone mutations, resulting in new virus variants. While no treatment is currently available, a naturally derived molecule with known antiviral properties could be used as a potential treatment. Bromelain is an enzyme found in the fruit and stem of pineapples. This substance has been shown to have a broad antiviral activity. In this article, we analyse the ability of bromelain to counteract various variants of the SARS-CoV-2 by targeting bromelain binding on the side of this viral interaction with human angiotensin-converting enzyme 2 (hACE2) using molecular docking and molecular dynamics simulation approaches. We have succeeded in making three-dimensional configurations of various RBD variants using protein modelling. Bromelain exhibited good binding affinity toward various variants of RBDs and binds right at the binding site between RBDs and hACE2. This result is also presented in the modelling between Bromelain, RBD, and hACE2. The molecular dynamics (MD) simulations study revealed significant stability of the bromelain and RBD proteins separately up to 100 ns with an RMSD value of 2 Å. Furthermore, despite increases in RMSD and changes in Rog values of complexes, which are likely due to some destabilized interactions between bromelain and RBD proteins, two proteins in each complex remained bonded, and the site where the two proteins bind remained unchanged. This finding indicated that bromelain could have an inhibitory effect on different SARS-CoV-2 variants, paving the way for a new SARS-CoV-2 inhibitor drug. However, more in vitro and in vivo research on this potential mechanism of action is required. [ABSTRACT FROM AUTHOR]

Published
2021
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99. AMELIORATION OF OLANZAPINE-INDUCED IMPAIRED GLUCOSE TOLERANCE IN MICE WITH METHANOL EXTRACT OF STEAMED Brassica oleracea (CABBAGE) LEAVES.

Author

NOOR, FARJANA AKTHER, CHAKRABORTY, SONGJUKTA, WIART, CHRISTOPHE, and RAHMATULLAH, MOHAMMED

Subjects
COLE crops, OLANZAPINE, BLOOD sugar, GLUCOSE tolerance tests, GLUCOSE, CABBAGE
Abstract

Olanzapine is an antipsychotic drug and has been reported to induce impaired glucose tolerance leading to high blood glucose levels. In oral glucose tolerance tests (OGTT), methanolic extract of steamed cabbage (Brassica oleracea L. var. capitata) (MEBO) leaves have been shown to reduce elevated blood glucose levels in glucose-loaded mice. It was thus of interest to determine whether MEBO leaves can ameliorate olanzapineinduced impaired glucose tolerance in mice, which have been administered olanzapine for 28 days. Impaired glucose tolerance was measured through OGTT in mice. Olanzapine (28 days)-administered mice showed elevated blood glucose in OGTT. MEBO leaves showed significant reduction of blood glucose level in OGTT in mice (compared to vehicle or olanzapine treated mice for 28 days, Groups 2 and 3, respectively) both when administered for 28 days along with olanzapine, as well when administered 60 min prior to glucose loading in OGTT (positive control glibenclamide administered at 10 mg/kg). A single dose of MEBO (400 mg/kg) was used based on previous studies. Thus, MEBO leaves can be beneficial for improving glucose tolerance and reduce blood glucose levels in olanzapine-induced elevated blood glucose levels. [ABSTRACT FROM AUTHOR]

Published
2020
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