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342 results on '"Qureshi, Waqas T."'

61. Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression‐based analysis

Author

Sattar, Yasar, primary, Abdul Razzack, Aminah, additional, Kompella, Ritika, additional, Alhajri, Noora, additional, Arshad, Junaid, additional, Ullah, Waqas, additional, Zghouzi, Mohamed, additional, Mir, Tanveer, additional, Power, David, additional, Qureshi, Waqas T., additional, Aljaroudi, Wael, additional, Elgendy, Islam Y., additional, Mamas, Mamas A., additional, and Alraies, M. Chadi, additional

Published
2021
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66. Post-Myocardial Infarction Complications During the COVID-19 Pandemic – A Case Series

Author

Qureshi, Waqas T., primary, Al-Drugh, Summer, additional, Ogunsua, Adedotun, additional, Harrington, Colleen, additional, Aman, Wahaj, additional, Balsam, Leora, additional, Kar, Biswajit, additional, Aurigemma, Gerald, additional, Kundu, Amartya, additional, Kaur, Nirmal, additional, Smith, Craig, additional, Fisher, Daniel, additional, Rade, Jeffrey, additional, and Kakouros, Nikolaos, additional

Published
2021
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71. ST-Elevation Myocardial Infarction Among Septic Shock and Coronary Interventions: A National Emergency Database Study.

Author

Mir, Tanveer, Uddin, Mohammed, Qureshi, Waqas T., Abohashem, Shady, Alqalyoobi, Shehabaldin, Sheikh, Mujeeb, Soubani, Ayman, Saydain, Ghulam, and Albertson, Timothy E.

Subjects
MYOCARDIAL infarction, SEPTIC shock, CORONARY angiography, PERCUTANEOUS coronary intervention, MORTALITY
Abstract

Objective: To study coronary interventions and mortality among patients with ST-elevated myocardial infarction (STEMI) who were admitted with septic shock. Methods: Data from the national emergency department sample (NEDS) that constitutes 20% sample of hospital-owned emergency departments in the United States was analyzed for the septic shock related visits from 2016 to 2018. Septic shock was defined by the ICD codes. Results: Out of 1 375 507 adult septic shock patients, 521 300 had a primary diagnosis of septic shock (mean age 67.41 ±15.67 years, 51.1% females) in the national emergency database for the years 2016 to 2018. Of these patients, 2768 (0.53%) had STEMI recorded during the hospitalization. Mortality rates for STEMI patients were higher than patients without STEMI (52.3% vs 23.5%). Mortality rates improved with PCI among STEMI patients (43.8% vs 56.2%). Coronary angiography was performed among 16% of patients of which percutaneous coronary intervention (PCI) rates were 7.7% among patients with STEMI septic shock. PCI numerically improved mortality, however, had no significant difference than patients without PCI on multivariate logistic regression and univariate logistic regression post coarsened exact matching of baseline characteristics among STEMI patients. Among the predictors, STEMI was a significant predictor of mortality in septic shock patients (OR 2.87, 95% CI 2.37-3.49; P<.001). Age, peripheral vascular disease, were predominant predictors of mortality in STEMI with septic shock subgroup (P <.001). Pneumonia was the predominant underlying infection among STEMI (36.4%) and without STEMI group (29.5%). Conclusion: STEMI complicating septic shock worsens mortality. PCI and coronary angiography numerically improved mortality, however, had no significant difference from patients without PCI. More research will be needed to improve mortality in such a critically ill subgroup of patients. [ABSTRACT FROM AUTHOR]

Published
2022
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72. Brain Natriuretic Peptide as a Marker of Adverse Neurological Outcomes Among Survivors of Cardiac Arrest.

Author

Dutta, Abhishek, Alirhayim, Zaid, Masmoudi, Youssef, Azizian, John, McDonald, Lawson, Jogu, Hanumantha R., Qureshi, Waqas T., and Majeed, Nasir

Subjects
BRAIN natriuretic factor, CARDIAC arrest, HEART failure, MORTALITY, BIOMARKERS
Abstract

Background: Neurological prognosis after cardiac arrest remains ill-defined. Plasma brain natriuretic peptide (BNP) may relate to poor neurological prognosis in brain-injury patients, though it has not been well studied in survivors of cardiac arrest. Methods:We performed a retrospective review and examined the association of BNP with mortality and neurological outcomes at discharge in a cohort of cardiac arrest survivors enrolled from January 2012 to December 2016 at the Wake Forest Baptist Hospital, in North Carolina. Cerebral performance category (CPC) and modified Rankin scales were calculated from the chart based on neurological evaluation performed at the time of discharge. The cohort was subdivided into quartiles based on their BNP levels after which multivariable adjusted logistic regression models were applied to assess for an association between BNP and poor neurological outcomes as defined by a CPC of 3 to 4 and a modified Rankin scale of 4 to 5. Results: Of the 657 patients included in the study, 254 patients survived until discharge. Among these, poor neurological status was observed in 101 (39.8%) patients that had a CPC score of 3 to 4 and 97 patients (38.2%) that had a modified Rankin scale of 4 to 5. Mean BNP levels were higher in patients with poor neurological status compared to those with good neurological status at discharge (P =.03 for CPC 3-4 and P=.02 for modified Rankin score 4-5). BNP levels however, did not vary significantly between patients that survived and those that expired (P=.22). BNP did emerge as a significant discriminator between patients with severe neurological disability at discharge when compared to those without. The area under the curve for BNP predicting a modified Rankin score of 4 to 5 was 0.800 (95% confidence interval [CI] 0.756-0.844, P < .001) and for predicting CPC 3 to 4 was 0.797 (95% CI 0.756-0.838, P < .001). BNP was able to significantly improve the net reclassification index and integrated discriminatory increment (P < .05). BNP was not associated with long-term all-cause mortality (P > .05). Conclusions: In survivors of either inpatient or out-of-hospital cardiac arrest, increased BNP levels measured at the time of arrest predicted severe neurological disability at discharge. We did not observe an independent association between BNP levels and long-term all-cause mortality. BNP may be a useful biomarker for predicting adverse neurological outcomes in survivors of cardiac arrest. [ABSTRACT FROM AUTHOR]

Published
2022
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73. Bioresorbable polymer and durable polymer metallic stents in coronary artery disease: a meta-analysis

Author

Mir, Tanveer, primary, Shanah, Layla, additional, Ahmad, Usman, additional, Sattar, Yasar, additional, Chokshi, Bhavin, additional, Aggarwal, Ankita, additional, Prakash, Preeya, additional, Attique, Hassan Bin, additional, Changal, Khalid Hamid, additional, Kumar, Kartik, additional, Alraies, Chadi, additional, Qureshi, Waqas T, additional, and Afonso, Luis, additional

Published
2021
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74. Post-PCI outcomes in STEMI patients with coronary ectasia: meta-analysis

Author

Mir, Tanveer, primary, Sattar, Yasar, additional, Uddin, Mohammed, additional, Changal, Khalid Hamid, additional, Kumar, Kartik, additional, Attique, Hassan Bin, additional, Kabashneh, Sohaip, additional, Ullah, Waqas, additional, Lohia, Prateek, additional, Alraies, M Chadi, additional, Blank, Nimrod, additional, Afonso, Luis, additional, and Qureshi, Waqas T, additional

Published
2021
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75. Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA)

Author

Yeboah, Joseph, Sillau, Stefan, Delaney, Joseph C., Blaha, Michael J., Michos, Erin D., Young, Rebekah, Qureshi, Waqas T., McClelland, Robyn, Burke, Gregory L., Psaty, Bruce M., and Herrington, David M.

Published
2015
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82. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

Author

Fretts, Amanda M, Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason HY, Murphy, Rachel A, Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G, Qureshi, Waqas T, Virtanen, Jyrki K, Wong, Kerry, Wood, Alexis C, Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B, Djoussé, Luc, Harris, Bill, Wareham, Nick J, Steffen, Lyn M, Laakso, Markku, Veenstra, Jenna, Samieri, Cécilia, Brouwer, Ingeborg A, Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T, Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, InterAct Consortium, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y, Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, Lemaitre, Rozenn N, Imamura, Fumiaki [0000-0002-6841-8396], Forouhi, Nita [0000-0002-5041-248X], Wareham, Nicholas [0000-0003-1422-2993], Koulman, Albert [0000-0001-9998-051X], and Apollo - University of Cambridge Repository

Subjects
Adult, Aged, 80 and over, Male, Fatty Acids and Outcomes Research Consortium, diabetes, Fatty Acids, Middle Aged, very-long-chain saturated fatty acids, meta-analysis, Diabetes Mellitus, Type 2, Eicosanoic Acids, Cohorts for Heart and Aging Research in Genomic Epidemiology, Humans, saturated fatty acids, Female, Prospective Studies, Aged
Abstract

BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.

Published
2019

83. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes : a pooled analysis of prospective cohort studies

Author

Fretts, Amanda M., Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H. Y., Murphy, Rachel A., Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G., Qureshi, Waqas T., Virtanen, Jyrki K., Wong, Kerry, Wood, Alexis C., Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B., Djousse, Luc, Harris, Bill, Wareham, Nick J., Steffen, Lyn M., Laakso, Markku, Veenstra, Jenna, Samieri, Cecilia, Brouwer, Ingeborg A., Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T., Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Consortium, InterAct, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y., Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, Lemaitre, Rozenn N., Fretts, Amanda M., Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason H. Y., Murphy, Rachel A., Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G., Qureshi, Waqas T., Virtanen, Jyrki K., Wong, Kerry, Wood, Alexis C., Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B., Djousse, Luc, Harris, Bill, Wareham, Nick J., Steffen, Lyn M., Laakso, Markku, Veenstra, Jenna, Samieri, Cecilia, Brouwer, Ingeborg A., Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T., Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, Consortium, InterAct, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y., Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, and Lemaitre, Rozenn N.

Abstract

Background: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Methods: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. Results: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. Conclusions: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.

Published
2019
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84. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

Author

Fretts, Amanda M, primary, Imamura, Fumiaki, additional, Marklund, Matti, additional, Micha, Renata, additional, Wu, Jason H Y, additional, Murphy, Rachel A, additional, Chien, Kuo-Liong, additional, McKnight, Barbara, additional, Tintle, Nathan, additional, Forouhi, Nita G, additional, Qureshi, Waqas T, additional, Virtanen, Jyrki K, additional, Wong, Kerry, additional, Wood, Alexis C, additional, Lankinen, Maria, additional, Rajaobelina, Kalina, additional, Harris, Tamara B, additional, Djoussé, Luc, additional, Harris, Bill, additional, Wareham, Nick J, additional, Steffen, Lyn M, additional, Laakso, Markku, additional, Veenstra, Jenna, additional, Samieri, Cécilia, additional, Brouwer, Ingeborg A, additional, Yu, Chaoyu Ian, additional, Koulman, Albert, additional, Steffen, Brian T, additional, Helmer, Catherine, additional, Sotoodehnia, Nona, additional, Siscovick, David, additional, Gudnason, Vilmundur, additional, Wagenknecht, Lynne, additional, Voutilainen, Sari, additional, Tsai, Michael Y, additional, Uusitupa, Matti, additional, Kalsbeek, Anya, additional, Berr, Claudine, additional, Mozaffarian, Dariush, additional, and Lemaitre, Rozenn N, additional

Published
2019
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85. Incidence, Predictors, and Prognosis of Acute Kidney Injury Among Cardiac Arrest Survivors.

Author

Dutta, Abhishek, Hari, Krupal J., Azizian, John, Masmoudi, Youssef, Khalid, Fatima, Kowal, Jamie L., Ahmad, Muhammad Imtiaz, Majeed, Maryam, Macdonald, Lawson, Sunkara, Padageshwar, and Qureshi, Waqas T.

Subjects
ACUTE kidney failure, CARDIAC arrest, HEMODIALYSIS, RENAL replacement therapy, CONFIDENCE intervals
Abstract

Background: Acute kidney injury (AKI) is common among cardiac arrest survivors. However, the outcomes and predictors are not well studied. Methods: This is a cohort study of cardiac arrest patients enrolled from January 2012 to December 2016 who were able to survive for 24 hours post-cardiopulmonary resuscitation. Patients with anuria, chronic kidney disease (stage 5), and end-stage renal disease were excluded. Acute kidney injury (stage 1) or higher was defined using Kidney Disease: Improving Global Outcomes classification. Multivariable adjusted regression models were used to compute hazard ratio (HR) for association of AKI with risk of mortality and odds ratio (OR) with risk of poor neurological outcomes after adjusting for demographics, comorbidities, and medical therapy. Multivariable logistic regression model was used to compute OR for association of various predictors with AKI. Results: Of 842 cardiac arrest survivors, 588 (69.8%) developed AKI. Among AKI patients, 69.4% died compared with 52.0% among non-AKI patients. In multivariable adjusted Cox proportional hazard model, development of AKI post-cardiac arrest was significantly associated with mortality (HR: 1.35; 95% confidence interval [CI]: 1.07-1.71, P = .01) and poor neurological outcomes defined as cerebral performance category >2 (OR: 2.27; 95% CI: 1.45-3.57, P < .001) and modified Rankin scale >3 (OR: 2.22; 95% CI: 1.43-3.45, P < .001). Postdischarge dialysis was also associated with increased risk of mortality (HR: 2.57; 95% CI: 1.57-4.23, P < .001). Use of vasopressors was strongly associated with development of AKI and continued need for postdischarge dialysis. Conclusions: Acute kidney injury was associated with increased risk of mortality and poor neurological outcomes. There is need for further studies to prevent AKI in cardiac arrest survivors. [ABSTRACT FROM AUTHOR]

Published
2021
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86. Short‐ and long‐term clinical predictors of pharmacological cardioversion of persistent atrial fibrillation by dofetilide: A retrospective cohort study of 160 patients

Author

Hassan Virk, Hafeez Ul, Qureshi, Waqas T., Makkar, Nayani, Bastawrose, Joseph, Souvaliotis, Nektarios, Aziz, Joshua, and Aziz, Emad

Subjects
Male, Sulfonamides, Time Factors, Dose-Response Relationship, Drug, Clinical Investigations, Middle Aged, Patient Readmission, Treatment Outcome, Heart Rate, Atrial Fibrillation, Phenethylamines, Potassium Channel Blockers, Humans, Female, Follow-Up Studies, Retrospective Studies
Abstract

INTRODUCTION: Dofetilide is a class III antiarrhythmic prescribed to cardiovert persistent atrial fibrillation (AF) to sinus rhythm (SR). HYPOTHESIS: To determine the clinical predictors of cardioversion and readmission in persistent AF patients on dofetilide. METHODS: We analyzed 160 patients with persistent AF who were started on dofetilide and followed for 1 year. We examined age, sex, race, hypertension, diabetes, smoking, dyslipidemia, CAD, left ventricular ejection fraction (LVEF), creatinine, BMI and concomitant use of calcium channel blockers (CCB), β‐blockers in a multivariable logistic regression model. We also examined the same predictors in Cox regression model for AF‐related readmission within 1 year of follow‐up. RESULTS: 13.5% individuals did not convert to SR on dofetilide. 55.6% converted on the first dose and 83.1% converted by the fourth dose. In multivariable logistic models, dyslipidemia (OR: 2.4, CI: 1.12‐5.16) and LVEF (OR: 3.83,CI: 1.37‐10.8) were associated with failure to convert with the first dose. Female sex and LVEF also were associated with increased risk of failure to convert at all. Concomitant use of CCB associated with decreased risk of failure to convert to SR. In Cox proportional model, female sex, age

Published
2017

91. Comparison of Echocardiographic Measures in a Hispanic/Latino Population With the 2005 and 2015 American Society of Echocardiography Reference Limits (The Echocardiographic Study of Latinos)CLINICAL PERSPECTIVE

Author

Shah, Sanjiv J., Hurwitz, Barry E., Leigh, J. Adam, Rodriguez, Carlos J., Dharod, Ajay, Allison, Matthew A., Swett, Katrina, Qureshi, Waqas T., Gonzalez, Franklyn, Cai, Jianwen, Spevack, Daniel M., and Desai, Ankit A.

Abstract

BACKGROUND: Reference limits for echocardiographic quantification of cardiac chambers in Hispanics are not well studied. METHODS AND RESULTS: We examined the reference values of left atrium and left ventricle (LV) structure in a large ethnically diverse Hispanic cohort. Two-dimensional transthoracic echocardiography was performed in 1818 participants of the Echocardiographic Study of Latinos (ECHO-SOL). Individuals with body mass index ≥30 kg/m(2), hypertension, diabetes mellitus, coronary artery disease, and atrial fibrillation were excluded leaving 525 participants defined as healthy reference cohort. We estimated 95th weighted percentiles of LV end systolic volume, LV end diastolic volume, relative wall and septal thickness, LV mass, and left atrial volume. We then used upper reference limits of the 2005 and 2015 American Society of Echocardiography (ASE) and 95th percentile of reference cohort to classify the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) target population into abnormal and normal. Reference limits were also calculated for each of 6 Hispanic origins. Using ASE 2015 defined reference values, we categorized 7%, 21%, 57%, and 17% of men and 18%, 29%, 60%, and 26% of women as having abnormal LV mass index, relative, septal, and posterior wall thickness, respectively. Conversely, 10% and 11% of men and 4% and 2% of women were classified as having abnormal end-diastolic volume and internal diameter by ASE 2015 cutoffs, respectively. Similar differences were found when we used 2005 ASE cutoffs. Several differences were noted in distribution of cardiac structure and volumes among various Hispanic/Latino origins. Cubans had highest values of echocardiographic measures, and Central Americans had the lowest. CONCLUSIONS: This is the first large study that provides normal reference values for cardiac structure. It further demonstrates that a considerable segment of Hispanic/Latinos residing in the United States may be classified as having abnormal measures of cardiac chambers when 2015 and 2005 ASE reference cutoffs are used.

Published
2016
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92. Abstract 451: Beta Blocker Use in Asymptomatic Patients with Sepsis and Elevated Troponin is Associated with Lower Risk of Mortality

Author

Jogu, Hanumantha R, primary, Chevli, Parag A, additional, Bose, Abhishek, additional, Vasireddy, Amit, additional, Sompalli, Sreeja, additional, Gopireddy, Guru Anirudh Reddy, additional, Dutta, Abhishek, additional, Maludum, Obiora, additional, Yarra, Pradeep, additional, Amjad, Aysha, additional, Menon, Suma, additional, Sunkara, Padageshwar R, additional, and Qureshi, Waqas T, additional

Published
2017
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93. American College of Cardiology/American Heart Association (ACC/AHA) Class I Guidelines for the Treatment of Cholesterol to Reduce Atherosclerotic Cardiovascular Risk: Implications for US Hispanics/Latinos Based on Findings From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Author

Qureshi, Waqas T., primary, Kaplan, Robert C., additional, Swett, Katrina, additional, Burke, Gregory, additional, Daviglus, Martha, additional, Jung, Molly, additional, Talavera, Gregory A., additional, Chirinos, Diana A., additional, Reina, Samantha A., additional, Davis, Sonia, additional, and Rodriguez, Carlos J., additional

Published
2017
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