55 results on '"Quarato, Pier Paolo"'
Search Results
52. Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABAA receptors microtranspianted to Xenopus oocytes.
- Author
-
Roseti, Cristina, Palma, Eleonora, Martinello, Katiuscia, Fucile, Sergio, Morace, Roberta, Esposito, Vincenzo, Cantore, Gianpaolo, Arcella, Antonietta, Giangaspero, Felice, Aronica, Eleonora, Mascia, Addolorata, Di Gennaro, Giancarlo, Quarato, Pier Paolo, Manfredi, Mario, Cristalli, Gloria, Lambertucci, Catia, Marucci, Gabriella, Volpini, Rosaria, Limatola, Cristina, and Eusebi, Fabrizio
- Subjects
DESENSITIZATION (Psychotherapy) ,XENOPUS ,DYSPLASIA ,CELL transformation ,PEOPLE with epilepsy - Abstract
We previously found that the endogenous anticonvulsant adenosine, acting through A
2A and A3 adenosine receptors (ARs), alters the stability of currents (IGABA ) generated by GABAA receptors expressed in the epileptic human mesial temporal lobe (MTLE). Here we examined whether AR5 alter the stability (desensitization) of IGABA expressed in focal cortical dysplasia (FCD) and in penglioma epileptic tissues. The experiments were performed with tissues from 23 patients, using voltage-clamp recordings in Xenopus oocytes microinjected with membranes isolated from human MTLE and FCD tissues or using patch-clamp recordings of pyramidal neurons in epileptic tissue slices. On repetitive activation, the epileptic GABAA receptors revealed instability, manifested by a large IGABA rundown, which in most of the oocytes (≈70%) was obviously impaired by the new A2A antagonists ANR82, ANR94, and ANR152. In most MILE tissue-microtransplanted oocytes, a new A3 receptor antagonist (ANR235) significantly improved IGABA stability. Moreover, patch-clamped pyramidal neurons from human neocortical slices of periglioma epileptic tissues exhibited altered IGABA rundown on ANR94 treatment. Our findings indicate that antagonizing A2A and A3 receptors increases the IGABA stability in different epileptic tissues and suggest that adenosine derivatives may offer therapeutic opportunities in various forms of human epilepsy. [ABSTRACT FROM AUTHOR]- Published
- 2009
- Full Text
- View/download PDF
53. Temporal lobe epilepsy surgery in children and adults: A multicenter study
- Author
-
Barba, Carmen, Cossu, Massimo, Guerrini, Renzo, Di Gennaro, Giancarlo, Villani, Flavio, De Palma, Luca, Grisotto, Laura, Consales, Alessandro, Battaglia, Domenica, Zamponi, Nelia, d’Orio, Piergiorgio, Revay, Martina, Rizzi, Michele, Casciato, Sara, Esposito, Vincenzo, Quarato, Pier Paolo, Di Giacomo, Roberta, Didato, Giuseppe, Pastori, Chiara, Pavia, Giusy Carfi, Pellacani, Simona, Matta, Giulia, Pacetti, Mattia, Tamburrini, Gianpiero, Cesaroni, Elisabetta, Colicchio, Gabriella, Vatti, Giampaolo, Asioli, Sofia, Caulo, Massimo, Marras, Carlo Efisio, Tassi, Laura, D’Aniello, Alfredo, Morace, Roberta, De Curtis, Marco, Deleo, Francesca, Giordano, Flavio, De Benedictis, Alessandro, Prato, Giulia, Perulli, Marco, Barba C., Cossu M., Guerrini R., Di Gennaro G., Villani F., De Palma L., Grisotto L., Consales A., Battaglia D., Zamponi N., d'Orio P., Revay M., Rizzi M., Casciato S., Esposito V., Quarato P.P., Di Giacomo R., Didato G., Pastori C., Carfi Pavia G., Pellacani S., Matta G., Pacetti M., Tamburrini G., Cesaroni E., Colicchio G., Vatti G., Asioli S., Caulo M., Marras C.E., and Tassi L.
- Subjects
0301 basic medicine ,Male ,Electroencephalography ,Neuropsychological Tests ,Hippocampus ,Neurosurgical Procedures ,Epilepsy ,0302 clinical medicine ,Postoperative Complications ,Cognition ,Epilepsy surgery ,Child ,seizure outcome ,medicine.diagnostic_test ,Age Factors ,Prognosis ,Temporal Lobe ,Malformations of Cortical Development ,Neurology ,Child, Preschool ,epilepsy surgery ,Anticonvulsants ,Female ,Adult ,medicine.medical_specialty ,Referral ,Adolescent ,Temporal lobe ,03 medical and health sciences ,Young Adult ,Settore MED/39 - NEUROPSICHIATRIA INFANTILE ,children ,Internal medicine ,Early Medical Intervention ,medicine ,Humans ,Preschool ,Retrospective Studies ,Hippocampal sclerosis ,Sclerosis ,business.industry ,Magnetic resonance imaging ,Odds ratio ,cognitive outcome ,medicine.disease ,030104 developmental biology ,Epilepsy, Temporal Lobe ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objective: To assess seizure and cognitive outcomes and their predictors in children (
- Full Text
- View/download PDF
54. Epilepsy surgery of 'low grade epilepsy associated neuroepithelial tumors': A retrospective nationwide Italian study
- Author
-
Gianfranco Vornetti, Gabriella Colicchio, Giovanni Tringali, Renzo Guerrini, Giancarlo Di Gennaro, Guido Rubboli, Marco Giulioni, Raffaele Rocchi, Pier Paolo Quarato, Paolo Nozza, Gianluca Marucci, Francesca Gozzo, Matteo Martinoni, Alessandro Consales, Vincenzo Esposito, Flavio Villani, Massimo Cossu, Luca De Palma, Carmen Barba, Giorgio Lo Russo, Veronica Pelliccia, Nicola Specchio, Flavio Giordano, Giuseppe Didato, Carlo Efisio Marras, Paolo Tinuper, Corrado Zenesini, Francesco Cardinale, DIPARTIMENTO DI EMATOLOGIA E SCIENZE ONCOLOGICHE 'L. e A. SERAGNOLI', DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE, DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE, Facolta' di MEDICINA e CHIRURGIA, Da definire, AREA MIN. 06 - Scienze mediche, Giulioni, Marco, Marucci, Gianluca, Pelliccia, Veronica, Gozzo, Francesca, Barba, Carmen, Didato, Giuseppe, Villani, Flavio, Di Gennaro, Giancarlo, Quarato, Pier Paolo, Esposito, Vincenzo, Consales, Alessandro, Martinoni, Matteo, Vornetti, Gianfranco, Zenesini, Corrado, Carlo, Efisio Marra, Specchio, Nicola, De Palma, Luca, Rocchi, Raffaele, Giordano, Flavio, Tringali, Giovanni, Nozza, Paolo, Colicchio, Gabriella, Rubboli, Guido, Lo Russo, Giorgio, Guerrini, Renzo, Tinuper, Paolo, Cardinale, Francesco, and Cossu, Massimo
- Subjects
Male ,Drug Resistant Epilepsy ,Multivariate analysis ,Epilepsy ,0302 clinical medicine ,Glioneuronal tumors ,Retrospective Studie ,Neoplasms ,Epilepsy surgery ,Low-grade glial tumors ,Neuropsychological outcome ,Child ,Brain Neoplasms ,Neuropsychology ,Neoplasms, Neuroepithelial ,Treatment Outcome ,Focal cortical dysplasia ,Seizure outcome ,Adolescent ,Adult ,Female ,Follow-Up Studies ,Humans ,Italy ,Retrospective Studies ,Young Adult ,Neurology ,Neurology (clinical) ,030220 oncology & carcinogenesis ,Human ,Italy/epidemiology ,medicine.medical_specialty ,Drug Resistant Epilepsy/diagnosis ,Neuroepithelial ,Follow-Up Studie ,Brain Neoplasm ,03 medical and health sciences ,Neoplasms, Neuroepithelial/diagnosis ,Internal medicine ,Low-grade glial tumor ,medicine ,Glioneuronal tumor ,Brain Neoplasms/diagnosis ,business.industry ,Retrospective cohort study ,Odds ratio ,Cortical dysplasia ,medicine.disease ,Surgery ,Relative risk ,business ,030217 neurology & neurosurgery - Abstract
none 28 no Objective: To analyze the attitude and results of Italian epilepsy surgery centers in the surgical management of âlow grade epilepsy associated neuroepithelial tumorsâ (LEATs). Methods: We conducted a retrospective study enrolling 339 consecutive patients with LEATs who underwent surgery between January 2009 and June 2015 at eight Italian epilepsy surgery centers. We compared demographic, clinical, pathologic, and surgical features of patients with favorable (Engel class I) and unfavorable (Engel class II, III, and IV) seizure outcome. In addition, we compared patients with tumor-associated focal cortical dysplasia (FCD) and patients with solitary tumors to identify factors correlated with FCD diagnosis. Results: Fifty-five (98.2%) of 56 patients with medically controlled epilepsy were seizure-free after surgery, compared to 249 (88.0%) of 283 patients with refractory epilepsy. At multivariate analysis, three variables independently predict unfavorable seizure outcome in the drug-resistant group. Age at surgery is largely the most significant (p = 0.001), with an odds ratio (OR) of 1.04. This means that the probability of seizure recurrence grows by 4% for every waited year. The resection site is also significant (p = 0.039), with a relative risk (RR) of 1.99 for extratemporal tumors. Finally, the completeness of tumor resection has a trend toward significance (p = 0.092), with an RR of 1.82 for incomplete resection. Among pediatric patients, a longer duration of epilepsy was significantly associated with preoperative neuropsychological deficits (pÂ
- Published
- 2017
55. Whole-brain voxel-based morphometry study of children and adolescents with Down syndrome.
- Author
-
Carducci F, Onorati P, Condoluci C, Di Gennaro G, Quarato PP, Pierallini A, Sarà M, Miano S, Cornia R, and Albertini G
- Subjects
- Adolescent, Analysis of Variance, Child, Chromosomes, Human, Pair 21 genetics, Data Interpretation, Statistical, Down Syndrome cerebrospinal fluid, Female, Functional Laterality physiology, Humans, Image Processing, Computer-Assisted, Male, Brain pathology, Down Syndrome pathology, Magnetic Resonance Imaging methods
- Abstract
In order to investigate alterations in brain morphology and a possible temporal pattern of neuroanatomical abnormalities in the gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) of young patients with Down syndrome (DS), high-resolution magnetic resonance imaging (MRI) voxel-based morphometry (VBM) was performed on 21 children and adolescents with this chromosomal aberration and 27 age-matched participants as controls. In comparison with control subjects, children and adolescents with DS showed not only an overall smaller whole-brain volume, but also volume reductions of the GM in the cerebellum, frontal lobes, frontal region of the limbic lobe, parahippocampal gyri and hippocampi and of the WM in the cerebellum, frontal and parietal lobes, sub-lobar regions and brainstem. By contrast, volume preservation was observed in the GM of the parietal lobes, temporal lobe and sub-lobar regions and in the WM of the temporal lobe and temporal regions of the limbic lobe. A lower volume of CSF was also detected in the frontal lobes. This study is the first to use the high-resolution MRI VBM method to describe a whole-brain pattern of abnormalities in young DS patients falling within such a narrow age range and it provides new information on the neuroanatomically specific regional changes that occur during development in these patients.
- Published
- 2013
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.