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370 results on '"Qiu, Yongming"'

63. AHIF promotes glioblastoma progression and radioresistance via exosomes

Author

Dai, Xuejun, primary, Liao, Keman, additional, Zhuang, Zhijun, additional, Chen, Binghong, additional, Zhou, Zhiyi, additional, Zhou, Sunhai, additional, Lin, Guoshi, additional, Zhang, Feifei, additional, Lin, Yingying, additional, Miao, Yifeng, additional, Li, Zhiqiang, additional, Huang, Renhua, additional, Qiu, Yongming, additional, and Lin, Ruisheng, additional

Published
2018
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65. Cerebral venous sinus thrombosis with cerebral hemorrhage during early pregnancy

Author

Nie, Quanmin, Guo, Pin, Ge, Jianwei, and Qiu, Yongming

Subjects
Adult, Pregnancy Complications, Sinus Thrombosis, Intracranial, Treatment Outcome, Pregnancy, Anticoagulants, Brain, Humans, Case Report, Female, Tomography, X-Ray Computed, Cerebral Hemorrhage
Abstract

Cerebral venous sinus thrombosis (CVST) rarely induces cerebral hemorrhage, and CVST with cerebral hemorrhage during early pregnancy is extremely rare. Upon literature review, we are able to find only one case of CVST with cerebral hemorrhage in early pregnancy. In this paper, we report another case of a 27-year-old patient who developed CVST with cerebral hemorrhage in her fifth week of pregnancy. Although the optimal treatment for this infrequent condition remains controversial, we adopted anticoagulation as the first choice of treatment and obtained favorable results.

Published
2015

66. Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma.

Author

Lin, Yingying, Liao, Keman, Miao, Yifeng, Qian, Zhongrun, Fang, Zhaoyuan, Yang, Xi, Nie, Quanmin, Jiang, Gan, Liu, Jianhua, Yu, Yiyi, Wan, Jieqing, Zhang, Xiaohua, Hu, Yaomin, Jiang, Jiyao, and Qiu, Yongming

Subjects
GLIOBLASTOMA multiforme, ASPARAGINE, VESICLES (Cytology), ISOCITRATE dehydrogenase, ENZYME-linked immunosorbent assay, KI-67 antigen, PROTEIN metabolism, DISEASE progression, RESEARCH, XENOGRAFTS, PROTEASE inhibitors, ANIMAL experimentation, RESEARCH methodology, PROTEOLYTIC enzymes, GLIOMAS, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, CONNECTIVE tissue cells, CELL lines, EPITHELIAL cells, MICE, PHARMACODYNAMICS
Abstract

Background: Isocitrate dehydrogenase wild-type (WT) glioblastoma (GBM) accounts for 90% of all GBMs, yet only 27% of isocitrate dehydrogenase WT-GBMs have p53 mutations. However, the tumor surveillance function of WT-p53 in GBM is subverted by mechanisms that are not fully understood.Methods: We investigated the proteolytic inactivation of WT-p53 by asparaginyl endopeptidase (AEP) and its effects on GBM progression in cancer cells, murine models, and patients' specimens using biochemical and functional assays. The sera of healthy donors (n = 48) and GBM patients (n = 20) were examined by enzyme-linked immunosorbent assay. Furthermore, effects of AEP inhibitors on GBM progression were evaluated in murine models (n = 6-8 per group). The statistical significance between groups was determined using two-tailed Student t tests.Results: We demonstrate that AEP binds to and directly cleaves WT-p53, resulting in the inhibition of WT-p53-mediated tumor suppressor function in both tumor cells and stromal cells via extracellular vesicle communication. High expression of uncleavable p53-N311A-mutant rescue AEP-induced tumorigenesis, proliferation, and anti-apoptotic abilities. Knock down or pharmacological inhibition of AEP reduced tumorigenesis and prolonged survival in murine models. However, overexpression of AEP promoted tumorigenesis and shortened the survival time. Moreover, high AEP levels in GBM tissues were associated with a poor prognosis of GBM patients (n = 83; hazard ratio = 3.94, 95% confidence interval = 1.87 to 8.28; P < .001). A correlation was found between high plasma AEP levels and a larger tumor size in GBM patients (r = 0.6, P = .03), which decreased dramatically after surgery.Conclusions: Our results indicate that AEP promotes GBM progression via inactivation of WT-p53 and may serve as a prognostic and therapeutic target for GBM. [ABSTRACT FROM AUTHOR]

Published
2020
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67. A rare intramedullary spinal cord metastasis from prostate carcinoma

Author

Guo, Liemei, Zhong, Chunlong, Jiang, Jiyao, and Qiu, Yongming

Subjects
Prostate cancer -- Case studies -- Diagnosis -- Care and treatment, Metastasis -- Case studies -- Diagnosis -- Care and treatment, Central nervous system diseases -- Case studies -- Diagnosis -- Care and treatment, Health
Abstract

Byline: Liemei. Guo, Chunlong. Zhong, Jiyao. Jiang, Yongming. Qiu Sir, A 74-year-old man presented with a 2-week history of decreased sensation and weakness of bilateral lower extremities along with urinary [...]

Published
2013

68. Minimally-invasive aspiration and drainage for management of traumatic epidural hematoma straddling transverse sinus

Author

Lu, Zhaofeng, Zhu, Gangyi, Qiu, Yongming, and Cheng, Xiaobing

Subjects
Hematoma -- Health aspects -- Genetic aspects -- Care and treatment -- Research, Biopsy, Needle -- Health aspects, Urokinase -- Health aspects -- Physiological aspects -- Genetic aspects -- Research, CT imaging -- Usage -- Health aspects, Health
Abstract

Byline: Zhaofeng. Lu, Gangyi. Zhu, Yongming. Qiu, Xiaobing. Cheng Aims: To investigate the therapeutic effect of minimally-invasive aspiration and drainage in traumatic epidural hematoma straddling transverse sinus (TEHSTS). Materials and [...]

Published
2013

73. A dural arterioveous fistula at the foramen magnum treated with transarterial Onyx embolization

Author

Guo, Liemei and Qiu, Yongming

Subjects
Fistula -- Risk factors -- Diagnosis -- Care and treatment -- Patient outcomes -- Case studies, Therapeutic embolization -- Health aspects, CT imaging -- Usage -- Health aspects, Health
Abstract

Byline: Liemei. Guo, Yongming. Qiu Sir, A 45-year-old male was admitted with headache and vomiting of one-day duration. Physical examination revealed neck stiffness. Cranial computed tomography (CT) scan showed subarachnoid [...]

Published
2012

75. A Hypothesis of Traumatic Subdural Effusion Associated With Communicating Hydrocephalus in Infants and Its Management

Author

Qiu Yongming, Xi Yang, Nie Quanmin, Que Shuang Lin, Lin Shen, and Ren Li

Subjects
medicine.medical_specialty, animal diseases, Culprit, Sinus Thrombosis, Intracranial, medicine, Humans, In patient, Cerebral venous sinus thrombosis, Subdural effusion, Collapse (medical), Communicating hydrocephalus, Transverse Sinuses, business.industry, Infant, Phlebography, General Medicine, medicine.disease, Thrombosis, Cerebrospinal Fluid Shunts, Subdural Effusion, nervous system diseases, Hydrocephalus, Surgery, Otorhinolaryngology, Brain Injuries, Female, medicine.symptom, business, Magnetic Resonance Angiography
Abstract

We report a case with both traumatic subdural effusion (TSE) and associated hydrocephalus. A collapse of the sinuses is known to be present in some infants with external hydrocephalus, but collapsed sinuses have not been previously described in patients with TSE and associated hydrocephalus. Therefore, a preoperative magnetic resonance imaging venography was performed, with thrombosis in the left transverse and sigmoid sinuses identified. The infant was treated with subdural peritoneostomy. We hypothesized that an occlusive cerebral venous sinus thrombosis may well be the culprit, or an exacerbating factor for TSE associated with hydrocephalus.

Published
2015

76. Kissing aneurysms of the internal carotid artery treated with surgical clipping

Author

Guo, Liemei, Qiu, Yongming, Ge, Jianwei, and Zhang, Xiaohua

Subjects
Blood vessels -- Surgery, Angiography -- Usage, CT imaging -- Usage, Aneurysms -- Care and treatment -- Diagnosis -- Case studies, Health
Abstract

Byline: Liemei. Guo, Yongming. Qiu, Jianwei. Ge, Xiaohua. Zhang Sir, A 50-year-old female presented with severe headache of 20 h duration. Neurological examination was unremarkable except for neck stiffness. Cranial [...]

Published
2012

77. The mechanism of pathological changes of intraventricular hemorrhage in dogs

Author

Dai, Jiong, Li, Shanquan, Li, Xiaoxiong, Xiong, Wenhao, and Qiu, Yongming

Subjects
Brain damage -- Research -- Risk factors -- Diagnosis, Intraventricular hemorrhage -- Risk factors -- Diagnosis -- Research, Health, Diagnosis, Research, Risk factors
Abstract

Byline: Jiong. Dai, Shanquan. Li, Xiaoxiong. Li, Wenhao. Xiong, Yongming. Qiu Background : Intraventricular hemorrhage (IVH) is an independent risk factor for both morbidity and mortality in patients with intracerebral [...]

Published
2009

79. Neuroprotective effect of sophocarpine against transient focal cerebral ischemia via down-regulation of the acid-sensing ion channel 1 in rats

Author

Wu Bin, Bing Li, Miao Yi-feng, Zhang Weiqiao, Xiao-jie Lu, and Qiu Yongming

Subjects
Brain Infarction, Male, Central nervous system, Ischemia, Down-Regulation, Apoptosis, Nerve Tissue Proteins, Pharmacology, Neuroprotection, Sodium Channels, Brain Ischemia, Rats, Sprague-Dawley, Brain ischemia, Alkaloids, medicine.artery, Animals, Medicine, Molecular Biology, Stroke, Acid-sensing ion channel, TUNEL assay, business.industry, General Neuroscience, Infarction, Middle Cerebral Artery, medicine.disease, Rats, Acid Sensing Ion Channels, Disease Models, Animal, Neuroprotective Agents, Treatment Outcome, medicine.anatomical_structure, Anesthesia, Middle cerebral artery, Neurology (clinical), business, Developmental Biology
Abstract

Sophocarpine, one of the major alkaloid compounds isolated from Sophora pachycarpa, is highly valued and important in traditional Chinese medicine. In the present study, we aimed to explore the possible mechanisms underlying sophocarpine-mediated neuroprotection against transient focal cerebral ischemia. Sophocarpine (5, 10, or 20mg/kg) was given 30min before focal ischemia was induced in rats by occlusion of the middle cerebral artery. After sophocarpine treatment, the total infarct volume was significantly decreased in comparison to the ischemia-reperfusion values. The results of a neurological evaluation were significantly improved in the sophocarpine treated group when compared to controls. The number of TUNEL-positive cells was significantly reduced compared to the untreated ischemic group. Results of Western blotting and immunohistochemical staining indicated that pretreatment with sophocarpine down-regulated the expression of acid-sensing ion channel 1 (ASIC1) in the ischemic cortex. These results suggest that sophocarpine ameliorated the ischemic injury induced by transient focal cerebral ischemia in rats and that this neuroprotective effect might be related to the anti-ASIC1 channel and anti-apoptotic action of sophocarpine.

Published
2011

84. The Role of Extracellular Vesicles: An Epigenetic View of the Cancer Microenvironment

Author

Qian, Zhongrun, Shen, Qi, Yang, Xi, Qiu, Yongming, and Zhang, Wenbin

Subjects
Article Subject
Abstract

Exosomes, microvesicles, and other extracellular vesicles are released by many cell types, including cancer cells and cancer-related immune cells. Extracellular vesicles can directly or indirectly facilitate the transfer of bioinformation to recipient cells or to the extracellular environment. In cancer, exosomes have been implicated in tumor initiation, proliferation, and metastasis. Extracellular vesicles can transmit proteins and nucleic acids that participate in DNA methylation, histone modification, and posttranscriptional regulation of RNA. Factors transmitted by extracellular vesicles reflect the donor cell status, and extracellular vesicles derived from tumor cells may be also responsible for altering expression of tumor promoting and tumor suppressing genes in recipient cells. Thus, circulating extracellular vesicles may act as biomarkers of cancer, and detection of these biomarkers may be applied to diagnosis or assessment of prognosis in patients with cancer.

Published
2015
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86. Our Experience of Transsylvian-Transinsular Microsurgical Approach to Hypertensive Putaminal Hematomas

Author

Jiang Ji-yao, Zhang Weiqiao, Luo Qi-zhong, Qiu Yongming, Ge Jianwei, and Zhang Xiaohua

Subjects
Adult, Male, Putaminal Hemorrhage, Microsurgery, medicine.medical_specialty, Frontal cortex, Decompression, Hematoma, medicine, Retrospective analysis, Humans, Glasgow Coma Scale, cardiovascular diseases, Surgical treatment, Aged, business.industry, General Medicine, Middle Aged, medicine.disease, Surgery, body regions, Putaminal Hematoma, Treatment Outcome, surgical procedures, operative, Otorhinolaryngology, Hypertension, cardiovascular system, Female, Neurosurgery, business
Abstract

Background There are different reports about operative methods for the treatment of hypertensive intracerebral hematomas. Our experience of transsylvian-transinsular microsurgical approach to hypertensive putaminal hematomas was analyzed. Methods A retrospective analysis was performed on 28 consecutive patients with hypertensive intracerebral hematomas who underwent surgical treatment at the Department of Neurosurgery, Renji Hospital, from January 2004 to December 2007. Results The transsylvian-transinsular approach to evacuate the hypertensive putaminal hematoma gains a good result. We believe it allows decompression of important deep-seated neurostructures with a more suitable angle and shorter distance from the cortex to the hematoma; allows easier access to vessels responsible for the bleeding, reducing the rate of rebleeding postoperatively; and avoids damage to the temporal or frontal cortex. Conclusions Transsylvian-transinsular approach for hypertensive putaminal hematoma is advocated.

Published
2009

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