19,667 results on '"Purvis, A."'
Search Results
52. Sustaining a New Model of Acute Stroke Care: A Mixed-Method Process Evaluation of the Melbourne Mobile Stroke Unit
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Kathleen L. Bagot, Tara Purvis, Shaun Hancock, Henry Zhao, Skye Coote, Damien Easton, Bruce CV Campbell, Stephen M. Davis, Geoff A. Donnan, Shane Foster, Francesca Langenberg, Karen Smith, Michael Stephenson, Stephen Bernard, Sharon McGowan, Bernard Yan, Peter Mitchell, Sandy Middleton, and Dominique A. Cadilhac
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stroke ,ambulances ,evaluation studies ,program sustainability ,Public aspects of medicine ,RA1-1270 - Abstract
Background Internationally, Mobile Stroke Unit (MSU) ambulances have changed pre-hospital acute stroke care delivery. MSU clinical and cost-effectiveness studies are emerging, but little is known about important factors for achieving sustainability of this innovative model of care.Methods Mixed-methods study from the Melbourne MSU (operational since November 2017) process evaluation. Participant purposive sampling included clinical, operational and executive/management representatives from Ambulance Victoria (AV) (emergency medical service provider), the MSU clinical team, and receiving hospitals. Sustainability was defined as ongoing MSU operations, including MSU workforce and future model considerations. Theoretically-based on-line survey with Unified Theory of Acceptance and Use of Technology (UTAUT), Self Determination Theory (SDT, Intrinsic Motivation), and open-text questions targeting barriers and benefits was administered (June-September 2019). Individual/group interviews were conducted, eliciting improvement suggestions and requirements for ongoing use. Descriptive and regression analyses (quantitative data) and directed content and thematic analysis (open text and interview data) were conducted.Results There were 135 surveys completed. Identifying that the MSU was beneficial to daily work (β = 0.61), not experiencing pressure/tension about working on the MSU (β = 0.17) and thinking they did well working within the team model (β = 0.17) were significantly associated with wanting to continue working within the MSU model [R2 = 0.76; F(15, 60) = 12.76, P < .001]. Experiences varied between those on the MSU team and those working with the MSU. Advantages were identified for patients (better, faster care) and clinicians (interdisciplinary learning). Disadvantages included challenges integrating into established systems, and establishing working relationships. Themes identified from 35 interviews were MSU team composition, MSU vehicle design and layout, personnel recruitment and rostering, communication improvements between organisations, telemedicine options, MSU operations and dispatch specificity.Conclusion Important factors affecting the sustainability of the MSU model of stroke care emerged. A cohesive team approach, with identifiable benefits and good communication between participating organisations is important for clinical and operational sustainability.
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- 2023
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53. Personalising genetic counselling (POETIC) trial: Protocol for a hybrid type II effectiveness-implementation randomised clinical trial of a patient screening tool to improve patient empowerment after cancer genetic counselling
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Laura E. Forrest, Erin Tutty, Anurika P. De Silva, Lara Petelin, Amy Ruscigno, Rebecca Purvis, Katrina Monohan, Maira Kentwell, Adrienne Sexton, Lesley Stafford, and Paul A. James
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Genetic counselling ,Hybrid effectiveness-implementation trial ,Patient screening tool ,Randomised control trial ,Medicine (General) ,R5-920 - Abstract
Abstract Background Genetic counselling aims to identify, and address, patient needs while facilitating informed decision-making about genetic testing and promoting empowerment and adaptation to genetic information. Increasing demand for cancer genetic testing and genetic counsellor workforce capacity limitations may impact the quality of genetic counselling provided. The use of a validated genetic-specific screening tool, the Genetic Psychosocial Risk Instrument (GPRI), may facilitate patient-centred genetic counselling. The aim of this study is to assess the effectiveness and implementation of using the GPRI in improving patient outcomes after genetic counselling and testing for an inherited cancer predisposition. Methods The PersOnalising gEneTIc Counselling (POETIC) trial is a hybrid type 2 effectiveness-implementation trial using a randomised control trial to assess the effectiveness of the GPRI in improving patient empowerment (primary outcome), while also assessing implementation from the perspective of clinicians and the healthcare service. Patients referred for a cancer risk assessment to the conjoint clinical genetics service of two metropolitan hospitals in Victoria, Australia, who meet the eligibility criteria and consent to POETIC will be randomised to the usual care or intervention group. Those in the intervention group will complete the GPRI prior to their appointment with the screening results available for the clinicians’ use during the appointment. Appointment audio recordings, clinician-reported information about the appointment, patient-reported outcome measures, and clinical data will be used to examine the effectiveness of using the GPRI. Appointment audio recordings, health economic information, and structured interviews will be used to examine the implementation of the GPRI. Discussion The POETIC trial takes a pragmatic approach by deploying the GPRI as an intervention in the routine clinical practice of a cancer-specific clinical genetics service that is staffed by a multidisciplinary team of genetics and oncology clinicians. Therefore, the effectiveness and implementation evidence generated from this real-world health service setting aims to optimise the relevance of the outcomes of this trial to the practice of genetic counselling while enhancing the operationalisation of the screening tool in routine practice. Trial registration Australian New Zealand Clinical Trials Registry registration number 12621001582842p. Date of registration: 19th November 2021.
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- 2023
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54. Schelling and Steffens
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Purvis, Zachary, Dole, Andrew C., book editor, Poe, Shelli M., book editor, and Vander Schel, Kevin M., book editor
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- 2023
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55. Harmonizing business practices of events and convention industry through sustainability assessment framework development
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Bart Aswain, Ilanur Elyssa, Ahmad Ludin, Norasikin, Jarimi, Hasila, Purvis-Robert, Kathleen L., Hamid, Norul Hisham, Mohd Shariff, Mohd Zulkifly, and Burke, John
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- 2024
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56. They Came but Could Not Conquer: The Struggle for Environmental Justice in Alaska Native Communities
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Diane J. Purvis and Diane J. Purvis
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- 2024
57. Safety and immunogenicity of a variant-adapted SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant as a booster in adults primed with authorized vaccines: a phase 3, parallel-group study
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de Bruyn, Guy, Wang, Joyce, Purvis, Annie, Ruiz, Martin Sanchez, Adhikarla, Haritha, Alvi, Saad, Bonaparte, Matthew I., Brune, Daniel, Bueso, Agustin, Canter, Richard M., Ceregido, Maria Angeles, Deshmukh, Sachin, Diemert, David, Finn, Adam, Forrat, Remi, Fu, Bo, Gallais, Julie, Griffin, Paul, Grillet, Marie-Helene, Haney, Owen, Henderson, Jeffrey A., Koutsoukos, Marguerite, Launay, Odile, Torres, Federico Martinon, Masotti, Roger, Michael, Nelson L., Park, Juliana, Rivera-Medina, Doris Maribel, Romanyak, Natalya, Rook, Chris, Schuerman, Lode, Sher, Lawrence D., Tavares-Da-Silva, Fernanda, Whittington, Ashley, Chicz, Roman M., Gurunathan, Sanjay, Savarino, Stephen, Sridhar, Saranya, Mohammed, Allaw, Valérie, Babin, Jennifer, Babyak, Ben-Ghezala, Ines, Breuer, Thomas, Breymeier, Corinne, Conrad, Anne, Holmqvist, Ciarrah, Costa-Araujo, Cristiana, Coux, Florence, Dellanno, Christine, Dussol, Bertrand, Essink, Brandon, Garrido, Jesús, Girodet, Pierre-Olivier, Gonzalez, Claudia, Grosbois, Marie-Ange, Hammond, Justin, He, Chelsea, Homlqvist, Ciarrah, Hudzina, Kathy, Hutchens, Mark, Jackson Booth, Peta-Gay, Joaquin, Arnel, Kandasamy, Rama, Kasztejna, Jennifer, Keefer, Michael, Kimmel, Murray, Kresge, Matthew, Laine, Fabrice, Lefebvre, Maeva, Lopez, Denise, Lourdes, Malaborbor Perpetua, Maakaroun-Vermesse, Zoha, Malishchak, Caitlin, Menard, Lisa, Mendoza, Sandra, Moore, Patrick, Mulamalla, Mounika, Mulholland, Patrick, Nicolas, Jean-Francois, Ogbuagu, Onyema, Ortiz, Juan, Perroud, Ana Paula, Peyton, Gina, Purvis, Ya-Fen, Raabe, Vanessa, Rivas, Enrique, Rouphael, Nadine, Roy, Beatrice, Sagot, Lola, Sater, Nessryne, Schwartz, Howard, Severance, Randall, Shi, Jiayuan, Sobieszczyk, Magdalena, Stevens, Charlene, Thuy, Tran Phuong, Toma, Ramy, Tong, Tina, Tourneux, Sophie, Treanor, John, Turet, Núria, Froget, Rachel, Walsh, Stephen, White, Judith, del Campo Perez, Victor, Perez Breva, Lina, Rojo Conejo, Pablo, Ruiz Antoraz, Maria Belen, Chin, Toong, Fribbens, Charlotte, Phillipson, Adrian, Kaminski, Rachel, Emmett, Stevan, Hebert, Corey, Birch, Thomas, Roberson, Russell, Zacher, Jeffrey, Gelu-Maury, Sophie, Loryne, Loron, and Davis, Yvonne
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- 2023
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58. Exploring Hesitancy, Motivations, and Practical Issues for COVID-19 Vaccination Among Vaccine-Hesitant Adopter Parents Using the Increasing Vaccination Model
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Purvis, Rachel S., Moore, Ramey, Willis, Don E., Li, Ji, Selig, James P., Kraleti, Shashank, Imran, Tabasum, and McElfish, Pearl A.
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- 2024
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59. Understanding HPV Vaccine Hesitancy and What Helped Hesitant Adopter Parents Have Their Children Vaccinated Despite Their Hesitancy
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Purvis, Rachel S., Moore, Ramey, Willis, Don E., Li, Ji, Kraleti, Shashank, Imran, Tabasum, and McElfish, Pearl A.
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- 2024
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60. Resource allocation in intensive care
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Purvis, Paul H. and McConnell, Paul C.
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- 2024
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61. Earthworm Watch: Insights into urban earthworm communities in the UK using citizen science
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Burton, Victoria J., Jones, Alan G., Robinson, Lucy D., Eggleton, Paul, and Purvis, Andy
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- 2024
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62. Impact of meta-roles on the evolution of organisational institutions
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Sedigh, Amir Hosein Afshar, Purvis, Martin K., Savarimuthu, Bastin Tony Roy, Purvis, Maryam A., and Frantz, Christopher K.
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Computer Science - Artificial Intelligence ,Computer Science - Computers and Society - Abstract
This paper investigates the impact of changes in agents' beliefs coupled with dynamics in agents' meta-roles on the evolution of institutions. The study embeds agents' meta-roles in the BDI architecture. In this context, the study scrutinises the impact of cognitive dissonance in agents due to unfairness of institutions. To showcase our model, two historical long-distance trading societies, namely Armenian merchants of New-Julfa and the English East India Company are simulated. Results show how change in roles of agents coupled with specific institutional characteristics leads to changes of the rules in the system., Comment: arXiv admin note: text overlap with arXiv:2004.11858
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- 2020
63. Impact of different belief facets on agents' decision -- a refined cognitive architecture to model the interaction between organisations' institutional characteristics and agents' behaviour
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Sedigh, Amir Hosein Afshar, Purvis, Martin K., Savarimuthu, Bastin Tony Roy, Frantz, Christopher K, and Purvis, Maryam A.
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Computer Science - Artificial Intelligence - Abstract
This paper presents a conceptual refinement of agent cognitive architecture inspired from the beliefs-desires-intentions (BDI) and the theory of planned behaviour (TPB) models, with an emphasis on different belief facets. This enables us to investigate the impact of personality and the way that an agent weights its internal beliefs and social sanctions on an agent's actions. The study also uses the concept of cognitive dissonance associated with the fairness of institutions to investigate the agents' behaviour. To showcase our model, we simulate two historical long-distance trading societies, namely Armenian merchants of New-Julfa and the English East India Company. The results demonstrate the importance of internal beliefs of agents as a pivotal aspect for following institutional rules., Comment: Submitted to COINE 2020 workshop
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- 2020
64. Personalising genetic counselling (POETIC) trial: Protocol for a hybrid type II effectiveness-implementation randomised clinical trial of a patient screening tool to improve patient empowerment after cancer genetic counselling
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Forrest, Laura E., Tutty, Erin, De Silva, Anurika P., Petelin, Lara, Ruscigno, Amy, Purvis, Rebecca, Monohan, Katrina, Kentwell, Maira, Sexton, Adrienne, Stafford, Lesley, and James, Paul A.
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- 2023
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65. Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and aspirin, versus IVIG and aspirin for prevention of coronary artery aneurysms (CAA) in Kawasaki disease (KD): the KD CAA prevention (KD-CAAP) trial protocol
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Eleftheriou, Despina, Moraes, Yolanda Collaco, Purvis, Cara, Pursell, Molly, Morillas, Marta Merida, Kahn, Robin, Mossberg, Maria, Kucera, Filip, Tulloh, Robert, Standing, Joseph F., Swallow, Veronica, McCormack, Rachael, Herberg, Jethro, Levin, Michael, Wan, Mandy, Klein, Nigel, Connon, Roisin, Walker, Ann Sarah, and Brogan, Paul
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- 2023
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66. Reaching late adopters: factors influencing COVID-19 vaccination of Marshallese and Hispanic adults
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Vincenzo, Jennifer L., Spear, Marissa J., Moore, Ramey, Purvis, Rachel S., Patton, Susan K., Callaghan-Koru, Jennifer, McElfish, Pearl A., and Curran, Geoffrey M.
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- 2023
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67. Critical reflections of postgraduate researchers on a collaborative interdisciplinary research project
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Purvis, Ben, Keding, Hannah, Lewis, Ashley, and Northall, Phil
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- 2023
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68. The impact of land use on non-native species incidence and number in local assemblages worldwide
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Liu, Daijun, Semenchuk, Philipp, Essl, Franz, Lenzner, Bernd, Moser, Dietmar, Blackburn, Tim M., Cassey, Phillip, Biancolini, Dino, Capinha, César, Dawson, Wayne, Dyer, Ellie E., Guénard, Benoit, Economo, Evan P., Kreft, Holger, Pergl, Jan, Pyšek, Petr, van Kleunen, Mark, Nentwig, Wolfgang, Rondinini, Carlo, Seebens, Hanno, Weigelt, Patrick, Winter, Marten, Purvis, Andy, and Dullinger, Stefan
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- 2023
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69. Trauma and release from prison
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Purvis, Charlotte, primary and Devine, Jenny, additional
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- 2023
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70. “It's not just words, it's something you can feel”
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Shingler, Jo, primary and Purvis, Charlotte, additional
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- 2023
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71. Efficacy and muscle safety assessment of fukutin-related protein gene therapy
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Halli Benasutti, Joseph W. Maricelli, Jane Seto, John Hall, Christine Halbert, Jacqueline Wicki, Lydia Heusgen, Nicholas Purvis, Michael Regnier, David C. Lin, Buel D. Rodgers, and Jeffrey S. Chamberlain
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gene therapy ,fukutin-related protein ,FKRP ,limb-girdle muscular dystrophy type R9 (LGMDR9) ,adeno-associated viral vector (AAV) ,physiology ,Genetics ,QH426-470 ,Cytology ,QH573-671 - Abstract
Limb-girdle muscular dystrophy type R9 (LGMDR9) is a muscle-wasting disease that begins in the hip and shoulder regions of the body. This disease is caused by mutations in fukutin-related protein (FKRP), a glycosyltransferase critical for maintaining muscle cell integrity. Here we investigated potential gene therapies for LGMDR9 containing an FKRP expression construct with untranslated region (UTR) modifications. Initial studies treated an aged dystrophic mouse model (FKRPP448L) with adeno-associated virus vector serotype 6 (AAV6). Grip strength improved in a dose- and time-dependent manner, injected mice exhibited fewer central nuclei and serum creatine kinase levels were 3- and 5-fold lower compared to those in non-injected FKRPP448L mice. Treatment also partially stabilized the respiratory pattern during exercise and improved treadmill running, partially protecting muscle from exercise-induced damage. Western blotting of C2C12 myotubes using a novel rabbit antibody confirmed heightened translation with the UTR modifications. We further explored the question of FKRP toxicity in wild-type mice using high doses of two additional muscle-tropic capsids: AAV9 and AAVMYO1. No toxic effects were detected with either therapeutic agent. These data further support the feasibility of gene therapy to treat LGMDR9.
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- 2023
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72. Pharmacokinetics and safety of bendamustine in the BEABOVP regimen for the treatment of pediatric patients with Hodgkin lymphoma
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Purvis, Katelyn N., Swanson, Hope D., Niloy, Kumar Kulldeep, Zhou, Yiwang, Panetta, John C., Crews, Kristine R., and Flerlage, Jamie E.
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- 2023
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73. An Exploratory Study of School Psychology Students’ Perceptions of Religious and Spiritual Diversity Training in their Graduate Programs
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Parker, Janise S., Murray, Kate, Boegel, Riley, Slough, Madeline, Purvis, Lee, and Geiling, Christie
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- 2023
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74. Drug repurposing screen identifies novel anti-inflammatory activity of sunitinib in macrophages
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Chaffey, Laura E., Roberti, Annabell, Bowman, Amelia, O'Brien, Conan JO., Som, Liliana, Purvis, Gareth SD., and Greaves, David R.
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- 2024
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75. Providers’ Perspectives of a Culturally Adapted CenteringPregnancy Intervention for Marshallese Women in Arkansas
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Holman-Allgood, Ijanae, Cline, Chloe, Durand, Chanelle, Purvis, Rachel S., Mendoza Kabua, Philmar, and Ayers, Britni L.
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- 2024
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76. Analysing temporal factor in dynamic life cycle assessment of solar photovoltaic system
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Alyssa Ahmad Affandi, Nurfarhana, Ahmad Ludin, Norasikin, Mukminah Junedi, Mirratul, Chin Haw, Lim, and Purvis-Roberts, Kathleen
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- 2024
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77. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmad, M, Ahmed, N, Ahmed, O, Ahmed, R, Ahmad, S, Ahmed, S H, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, A, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Alegria, A, Alexander, C, Alexander, J, Alexander, P, Al-Fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, F, Ali, J, Ali, M, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Aliyuda, F, Alizaedeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, 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Whitmore, D, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, H, Williamson, R, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Wilson, A, Wilson, B, Wilson, D, Willson, F, Wilson, I, Willson, J, Wilson, K-A, Wilson, L, Wilson, M, Wilson, T, Win, K, Win, M, Win, T, Win, W, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, Wishlade, T, Witele, E, Withers, N, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C H, Wong, E, Wong, J, Wong, K, Wong, M, Wong, N, Wong, S, Wong, T, Wood, A, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, B, Xia, Z, Y Ellis, T, Yacoba, E, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, W, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, M, Yates, T, Ye, J, Yearwood Martin, C, Yein, K, Yeoh, A, Yeung, C, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yu, C, Yuan, J, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-M, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, E, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2024
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78. Towards richer knowledge partnerships between ecology and ethnoecology
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Molnár, Zsolt, Aumeeruddy-Thomas, Yildiz, Babai, Dániel, Díaz, Sandra, Garnett, Stephen T., Hill, Rosemary, Bates, Peter, Brondízio, Eduardo S., Cariño, Joji, Demeter, László, Fernández-Llamazares, Álvaro, Guèze, Maximilien, McElwee, Pamela, Öllerer, Kinga, Purvis, Andy, Reyes-García, Victoria, Samakov, Aibek, and Singh, Ranjay K.
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- 2024
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79. Oversight of in-office dispensing and samples in dermatology
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Heron, Courtney E., Purvis, Caitlin G., Balogh, Esther A., Purvis, Robert S., and Feldman, Steven R.
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- 2023
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80. Ly6Chi Monocytes Are Metabolically Reprogrammed in the Blood during Inflammatory Stimulation and Require Intact OxPhos for Chemotaxis and Monocyte to Macrophage Differentiation
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Gareth S. D. Purvis, Eileen McNeill, Benjamin Wright, Keith M. Channon, and David R. Greaves
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Ly6Chi monocytes ,single cell transcriptomics ,OxPhos ,chemotaxis ,Cytology ,QH573-671 - Abstract
Acute inflammation is a rapid and dynamic process involving the recruitment and activation of multiple cell types in a coordinated and precise manner. Here, we investigate the origin and transcriptional reprogramming of monocytes using a model of acute inflammation, zymosan-induced peritonitis. Monocyte trafficking and adoptive transfer experiments confirmed that monocytes undergo rapid phenotypic change as they exit the blood and give rise to monocyte-derived macrophages that persist during the resolution of inflammation. Single-cell transcriptomics revealed significant heterogeneity within the surface marker-defined CD11b+Ly6G−Ly6Chi monocyte populations within the blood and at the site of inflammation. We show that two major transcriptional reprogramming events occur during the initial six hours of Ly6Chi monocyte mobilisation, one in the blood priming monocytes for migration and a second at the site of inflammation. Pathway analysis revealed an important role for oxidative phosphorylation (OxPhos) during both these reprogramming events. Experimentally, we demonstrate that OxPhos via the intact mitochondrial electron transport chain is essential for murine and human monocyte chemotaxis. Moreover, OxPhos is needed for monocyte-to-macrophage differentiation and macrophage M(IL-4) polarisation. These new findings from transcriptional profiling open up the possibility that shifting monocyte metabolic capacity towards OxPhos could facilitate enhanced macrophage M2-like polarisation to aid inflammation resolution and tissue repair.
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- 2024
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81. Cross-Correlations of Unresolved Multi-Neuron Recordings
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Bedenbaugh, Purvis, Destexhe, Alain, Series Editor, Brette, Romain, Series Editor, Aertsen, Ad, editor, Grün, Sonja, editor, Maldonado, Pedro E., editor, and Palm, Günther, editor
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- 2023
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82. Outcomes in patients with ETV6::RUNX1 or high-hyperdiploid B-ALL treated in the St. Jude Total Therapy XV/XVI studies
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Purvis, Katelyn, Zhou, Yinmei, Karol, Seth E., Rubnitz, Jeffrey E., Ribeiro, Raul C., Lee, Shawn, Yang, Jun J., Bowman, W. Paul, Wang, Lu, Dixon, Stephanie B., Roberts, Kathryn G., Gao, Qingsong, Cheng, Cheng, Mullighan, Charles G., Jeha, Sima, Pui, Ching-Hon, and Inaba, Hiroto
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- 2024
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83. A PROFESSIONAL DEVELOPMENT PROGRAM FOR SCIENCE ADJUNCT FACULTY: THE MENTORING-LEARNING COMMUNITY (MLC)
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Purvis, Linda B., Lang, Jason D., and Luft, Julie A.
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Professional development -- Evaluation ,Learning strategies -- Evaluation ,Education, Higher -- Curricula ,Science and technology - Abstract
Institutions of higher education have become increasingly dependent on adjunct faculty. These faculty members are often unfamiliar with current teaching strategies emphasizing an active learning approach. To support science adjunct faculty in learning about active learning, a professional development program was designed and implemented by the authors of this study, the Mentoring-Learning Community. The Mentoring-Learning Community program design was informed by literature regarding the use of professional development programs that focused on adjunct faculty. To determine the impact of this program, participants in the Mentoring-Learning Community were observed and interviewed over one semester. Mentoring-Learning Community participants transformed through all three Transformative Learning Theory dimensions, felt more empowered to utilize active learning approaches in their classrooms, and modified some aspects of their instruction. Keywords: adjunct, instructional change, professional development, transformation, Transformative Learning Theory, INTRODUCTION For many years, the demands of the growing student population in higher education were met by administrators hiring a significant number of adjunct faculty (Association for the Study of [...]
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- 2023
84. Safety and immunogenicity of a variant-adapted SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant as a booster in adults primed with authorized vaccines: a phase 3, parallel-group studyResearch in context
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Guy de Bruyn, Joyce Wang, Annie Purvis, Martin Sanchez Ruiz, Haritha Adhikarla, Saad Alvi, Matthew I. Bonaparte, Daniel Brune, Agustin Bueso, Richard M. Canter, Maria Angeles Ceregido, Sachin Deshmukh, David Diemert, Adam Finn, Remi Forrat, Bo Fu, Julie Gallais, Paul Griffin, Marie-Helene Grillet, Owen Haney, Jeffrey A. Henderson, Marguerite Koutsoukos, Odile Launay, Federico Martinon Torres, Roger Masotti, Nelson L. Michael, Juliana Park, Doris Maribel Rivera-Medina, Natalya Romanyak, Chris Rook, Lode Schuerman, Lawrence D. Sher, Fernanda Tavares-Da-Silva, Ashley Whittington, Roman M. Chicz, Sanjay Gurunathan, Stephen Savarino, Saranya Sridhar, Allaw Mohammed, Babin Valérie, Babyak Jennifer, Ines Ben-Ghezala, Thomas Breuer, Corinne Breymeier, Anne Conrad, Ciarrah Holmqvist, Cristiana Costa-Araujo, Florence Coux, Christine Dellanno, Bertrand Dussol, Brandon Essink, Jesús Garrido, Pierre-Olivier Girodet, Claudia Gonzalez, Marie-Ange Grosbois, Justin Hammond, Chelsea He, Ciarrah Homlqvist, Kathy Hudzina, Mark Hutchens, Peta-Gay Jackson Booth, Arnel Joaquin, Rama Kandasamy, Jennifer Kasztejna, Michael Keefer, Murray Kimmel, Matthew Kresge, Fabrice Laine, Maeva Lefebvre, Denise Lopez, Malaborbor Perpetua Lourdes, Zoha Maakaroun-Vermesse, Caitlin Malishchak, Lisa Menard, Sandra Mendoza, Patrick Moore, Mounika Mulamalla, Patrick Mulholland, Jean-Francois Nicolas, Onyema Ogbuagu, Juan Ortiz, Ana Paula Perroud, Gina Peyton, Ya-Fen Purvis, Vanessa Raabe, Enrique Rivas, Nadine Rouphael, Beatrice Roy, Lola Sagot, Nessryne Sater, Howard Schwartz, Randall Severance, Jiayuan Shi, Magdalena Sobieszczyk, Charlene Stevens, Tran Phuong Thuy, Ramy Toma, Tina Tong, Sophie Tourneux, John Treanor, Núria Turet, Rachel Froget, Stephen Walsh, Judith White, Victor del Campo Perez, Lina Perez Breva, Pablo Rojo Conejo, Maria Belen Ruiz Antoraz, Toong Chin, Charlotte Fribbens, Adrian Phillipson, Rachel Kaminski, Stevan Emmett, Corey Hebert, Thomas Birch, Russell Roberson, Jeffrey Zacher, Sophie Gelu-Maury, Loron Loryne, and Yvonne Davis
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AS03 adjuvant ,Beta ,Booster ,B.1.351 ,COVID-19 ,CoV2 preS dTM-AS03 ,Medicine (General) ,R5-920 - Abstract
Summary: Background: In a parallel-group, international, phase 3 study (ClinicalTrials.gov NCT04762680), we evaluated prototype (D614) and Beta (B.1.351) variant recombinant spike protein booster vaccines with AS03-adjuvant (CoV2 preS dTM-AS03). Methods: Adults, previously primed with mRNA (BNT162b2, mRNA-1273), adenovirus-vectored (Ad26.CoV2.S, ChAdOx1nCoV-19) or protein (CoV2 preS dTM-AS03 [monovalent D614; MV(D614)]) vaccines were enrolled between 29 July 2021 and 22 February 2022. Participants were stratified by age (18–55 and ≥ 56 years) and received one of the following CoV2 preS dTM-AS03 booster formulations: MV(D614) (n = 1285), MV(B.1.351) (n = 707) or bivalent D614 + B.1.351 (BiV; n = 625). Unvaccinated adults who tested negative on a SARS-CoV-2 rapid diagnostic test (control group, n = 479) received two primary doses, 21 days apart, of MV(D614). Anti-D614G and anti-B.1.351 antibodies were evaluated using validated pseudovirus (lentivirus) neutralization (PsVN) assay 14 days post-booster (day [D]15) in 18–55-year-old BNT162b2-primed participants and compared with those pre-booster (D1) and on D36 in 18–55-year-old controls (primary immunogenicity endpoints). PsVN titers to Omicron BA.1, BA.2 and BA.4/5 subvariants were also evaluated. Safety was evaluated over a 12-month follow-up period. Planned interim analyses are presented up to 14 days post-last vaccination for immunogenicity and over a median duration of 5 months for safety. Findings: All three boosters elicited robust anti-D614G or -B.1.351 PsVN responses for mRNA, adenovirus-vectored and protein vaccine-primed groups. Among BNT162b2-primed adults (18–55 years), geometric means of the individual post-booster versus pre-booster titer ratio (95% confidence interval [CI]) were: for MV (D614), 23.37 (18.58–29.38) (anti-D614G); for MV(B.1.351), 35.41 (26.71–46.95) (anti-B.1.351); and for BiV, 14.39 (11.39–18.28) (anti-D614G) and 34.18 (25.84–45.22 (anti-B.1.351). GMT ratios (98.3% CI) versus post-primary vaccination GMTs in controls, were: for MV(D614) booster, 2.16 (1.69; 2.75) [anti-D614G]; for MV(B.1.351), 1.96 (1.54; 2.50) [anti-B.1.351]; and for BiV, 2.34 (1.84; 2.96) [anti-D614G] and 1.39 (1.09; 1.77) [anti-B.1.351]. All booster formulations elicited cross-neutralizing antibodies against Omicron BA.2 (across priming vaccine subgroups), Omicron BA.1 (BNT162b2-primed participants) and Omicron BA.4/5 (BNT162b2-primed participants and MV D614-primed participants). Similar patterns in antibody responses were observed for participants aged ≥56 years. Reactogenicity tended to be transient and mild-to-moderate severity in all booster groups. No safety concerns were identified. Interpretation: CoV2 preS dTM-AS03 boosters demonstrated acceptable safety and elicited robust neutralizing antibodies against multiple variants, regardless of priming vaccine. Funding: Sanofi and Biomedical Advanced Research and Development Authority (BARDA).
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- 2023
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85. Trends in Retail Prices of Prescription Drugs Widely Used by Older Americans, 2006 to 2020
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Schondelmeyer, Stephen W., primary and Purvis, Leigh, additional
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- 2024
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86. Price Growth for Brand Name and Specialty Drugs Offset Price Decreases for Generic Drugs
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Schondelmeyer, Stephen W., primary and Purvis, Leigh, additional
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- 2024
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87. Genome sequencing with gene panel-based analysis for rare inherited conditions in a publicly funded healthcare system: implications for future testing
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Hocking, Lynne J., Andrews, Claire, Armstrong, Christine, Ansari, Morad, Baty, David, Berg, Jonathan, Bradley, Therese, Clark, Caroline, Diamond, Austin, Doherty, Jill, Lampe, Anne, McGowan, Ruth, Moore, David J., O’Sullivan, Dawn, Purvis, Andrew, Santoyo-Lopez, Javier, Westwood, Paul, Abbott, Michael, Williams, Nicola, Aitman, Timothy J., and Miedzybrodzka, Zosia
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- 2023
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88. How land use affects biodiversity: An analysis of the differences in the effects recorded on different continents
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Yidi Jiang and Andy Purvis
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Ecology ,QH540-549.5 - Abstract
Biodiversity provides humans with abundant natural resources, but due to human activities, land use has become one of the main factors determining the loss of biodiversity. Previous research has shown that land use has different effects on different species. To illustrate this phenomenon, this study used a wide range of sets of data to determine how land use affects species diversity worldwide, and whether this effect depends on the continent. This study mainly uses linear mixed-effects models (LMM) and generalized linear mixed-effects models (GLMM) to address the questions from two aspects: abundance and species richness. The results show that the responses of both abundance and species richness differ significantly between continents, which in Europe are significantly lower than in countries with primary vegetation. However, due to the sample size for Europe being much larger than that for Asia and Oceania, this result also indicates that the level of sampling could have biased the results.
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- 2023
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89. 'It’s Not a One-Time Conversation': Australian Parental Views on Supporting Young People in Relation to Pornography Exposure
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Sally Burke, Mayumi Purvis, Carol Sandiford, and Bianca Klettke
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pornography ,young people ,adolescence ,parental concern ,sexual education ,Australia ,Psychology ,BF1-990 - Abstract
While pornography provides opportunities for sexual exploration for young people, early and easy access also has possible negative implications for young people’s behavioural and sexual development. Parental responsibilities concerning their children’s consumption of pornography are largely misunderstood. This study explored parental experiences and beliefs about pornography education for young people using a qualitative study (n = 8, 6 females, 2 males). Interview data were analysed using a reflexive thematic approach. Results indicated that parents have concerns about the ease of access to pornography and the unmediated ideas it presents. Additionally, parents believe they have a responsibility to educate young people about pornography through having open and honest conversations and providing supervision. Further, parents believe that schools should be doing more to educate young people about pornography. This study extends upon current literature by suggesting that although parents feel well-equipped to communicate with and educate young people about pornography consumption, they lack confidence in their capacities to do this.
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- 2023
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90. A University and Public High School Partnership for Personalized, Accelerated Science Learning
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Erin Purvis, Richard Gordon, Louis Lozzi, and Loretta Flanagan-Cato
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community engagement course ,education disparity ,diversity and inclusion ,hands-on learning ,STEM education ,Education ,Communities. Classes. Races ,HT51-1595 - Abstract
Many public schools serving students who are under-represented in STEM fields lack the resources to provide the science education expected in the twenty-first century economy. Universities can deploy their infrastructure and human capital to better support local public schools, better preparing the next generation of college students for success in higher education and access to STEM-related careers. This article describes a university-public school partnership between the University of Pennsylvania (Penn) and Paul Robeson High School designed to accelerate the science learning of Paul Robeson High School students by having Penn college students teach hands-on lab activities on the college campus. Here, the partnership is described from the perspective of the school principal and school-based teacher leader for science and math at Paul Robeson High School. We discuss results from recent state standardized exams suggesting that these activities improve science knowledge and understanding for the high school students. A key ingredient for the improved science skills may be the broad social aspects of feeling included in the university setting.
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- 2024
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91. Global trends in biodiversity with tree plantation age
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Sophie Jane Tudge, Zoe M. Harris, Richard J. Murphy, Andy Purvis, and Adriana De Palma
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Agriculture ,Biodiversity ,Oil palm ,Plantation ,Restoration ,Trend ,Ecology ,QH540-549.5 - Abstract
Tree plantations are expanding globally to satisfy demands for wood, food, energy, oil and other ecosystem services, often replacing primary vegetation. Plantations are generally less biodiverse than primary vegetation, yet the effects of plantation age on biodiversity are not well understood. More accurate estimations of biodiversity within plantations over time could improve predictions of the ecological effects of tree planting, guiding more sustainable land use and management decisions. Here, we assess the effects of plantation age on the abundance and number of species of invertebrates, birds, plants, mammals, amphibians, reptiles and lichens, and on compositional similarity to minimally-used primary vegetation. We find that plantations usually support fewer species than both minimally-used primary vegetation and mature secondary vegetation, fewer individuals, and some novel species (i.e. species not also found in primary vegetation). We also find that, on a global scale, plantation age has positive effects on species richness, the abundance of individuals, and compositional similarity to primary vegetation. However, geographic realm, biome, management intensity and plantation type influence the biodiversity trends. We also include a case study for oil palm, showing that species richness increases with oil palm plantation age. Nevertheless, plantations typically remain less biodiverse than natural vegetation even thirty years after planting, especially in the tropics, where compositional similarity between plantations and minimally-used primary vegetation remains approximately 20% lower than the non-tropics. Our results highlight the negative ecological consequences of establishing new plantations in place of primary vegetation or restoration, yet we also reveal spatio-temporal differences in plantation biodiversity.
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- 2023
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92. Global trends in biodiversity with tree plantation age
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Tudge, Sophie Jane, Harris, Zoe M., Murphy, Richard J., Purvis, Andy, and De Palma, Adriana
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- 2023
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93. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Abidin, A, Aboaba, A, Aboagye-Odei, A, Aboah, C, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, HJ, Abu-Arafeh, A, Abubacker, SM, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, F, Acheampong, P, Acheampong, S, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, AS, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adatia, K, Adcock, K, Addai-Boampong, L, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, FW, Adesemoye, OA, Adewunmi, EO, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikari, B, Adhikari, SA, Adhikary, R, Aditya, A, Adjepong, P, Adkins, G, Adnan, A, Adriaanse, M, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Afrim, P, Afriyie, FA, Aftab, ZA, Afum-Adjei Awuah, A, Agarwal, M, Agasiya, PN, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Agyekum, JA, Agyen, K, Ahadome, EK, Ahamed Sadiq, S, Ahammed Nazeer, MH, Ahmad, M, Ahmad, S, Ahmed, A, Ahmed, BAR, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmed, M, Ahmed, MC, Ahmed, MS, Ahmed, N, Ahmed, O, Ahmed, RA, Ahmed, R, Ahmed, S, Ahmed, SG, Ahmed, SH, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aidoo, C, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, ASAR, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albertus, A, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Ale, RM, Alegria, A, Alexander, A, Alexander, C, Alexander, J, Alexander, PDG, Al-fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, FR, Ali, J, Ali, M, Ali, MS, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Alisjahbana, B, Aliyuda, F, Alizadeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsop, HK, Allsop, L, Allsup, D, Almahroos, AFT, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, Al-Rabahi, A, Al-Ramadhani, B, Al-Saadi, Z, Al-Sammarraie, R, Alshaer, I, Al-Shahi Salman, R, Al-Shamkhani, W, Alsheikh, F, Al-Sheklly, B, Altaf, S, Alty, A, Alvarez, M, Alvarez Corral, M, Alveyn, E, Alzetani, M, Amamou, S, Amar, N, Ambalavanan, S, Ambrogetti, R, Ambrose, C, Ameen, A, Amelia Ganefianty, A, Ames, K, Amezaga, MR, Amin, A, Amin, K, Amin, S, Amin, T, Amit, B, Amjad, A, Amjad, N, Amoah-Dankwa, J, Amoako-Adusei, A, Amosun, V, Amsal, M, Amsha, K, Amuasi, J, Amutio Martin, N, Amy, P, Anada, A, Anand, A, Anandappa, S, Anantapatnaikuni, SD, Andari, NKN, Anderson, E, Anderson, J, Anderson, L, Anderson, M, Anderson, N, Anderson, R, Anderson, S, Anderson, W, Andreou, P, Andrews, A, Andrews, J, Aneke, K, Ang, A, Ang, WW, Angel, T, Angela, A, Angelini, P, Anguvaa, L, Anichtchik, O, Anim-Somuah, M, Aniruddhan, K, Annett, J, Anning, L, Ansah, M, Anstey, PJ, Anstey, R, Anthony, A, Anthony-Pillai, A, Antill, P, Antonina, Z, Anu, V, Anwar, M, Anwar, S, Apetri, E, Apostolopoulos, A, 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Yeung, CY, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yovita, H, Yu, C, Yuan, JSJ, Yufaniaputri, N, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-S, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zayed, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zhu, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, ET, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2023
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94. Development and evaluation of a community-engaged research training program: Building capacity of Marshallese stakeholders and academic researchers to conduct health research
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McElfish, Pearl A, Rowland, Brett, Ayers, Britni L, O'Connor, Gail E, Purvis, Rachel S, Aitaoto, Nia, Capelle, Lucy, Laelan, Melisa, Felix, Holly C, Stewart, MKathryn, and Yeary, Karen HK
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- 2019
95. The social ecology of illicit protection : a history of the drug trade in Northern Ireland
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Purvis, William
- Abstract
This thesis studies the evolution of illicit drug markets in Northern Ireland. The analysis spans roughly four decades, exploring how conflict, ceasefires, and relative peace have shaped demand and supply. This study deconstructs paradoxical assumptions that underpin rhetoric surrounding the role of paramilitary organisations in the drug trade: primarily the widespread belief that organisations successfully curtailed demand for, and supply of, illicit drugs in order to protect citizens; and then subsequently played a central role in the rapid growth of markets including facilitating large scale trafficking. The analysis illustrates that informal control of drugs is tied to wider social mechanisms and processes that organisations experience alongside the communities that they form part of; and that early growth of drug markets is largely attributable to actors who are unaffiliated with such organisations and who do not experience the constraints that membership brings. Moreover, this study shows that the market for protection surrounding illicit drug supply has changed considerably over time; and that the paradoxes inherent in public discourse are largely based on confusion between the supply of protection and functional roles in the drug trade. This study demonstrates that the norms and rules that underwrite drug markets can evolve and change, creating opportunities for new and existing actors. Ultimately, the analysis situates drug markets in Northern Ireland within the context of the social forces that underpin informal control of people and place, which provides a more nuanced understanding of the demand for, and supply of, illicit protection beyond the obvious consequences of prohibition and the role of state.
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- 2021
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96. The impact of land use on non-native species incidence and number in local assemblages worldwide
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Daijun Liu, Philipp Semenchuk, Franz Essl, Bernd Lenzner, Dietmar Moser, Tim M. Blackburn, Phillip Cassey, Dino Biancolini, César Capinha, Wayne Dawson, Ellie E. Dyer, Benoit Guénard, Evan P. Economo, Holger Kreft, Jan Pergl, Petr Pyšek, Mark van Kleunen, Wolfgang Nentwig, Carlo Rondinini, Hanno Seebens, Patrick Weigelt, Marten Winter, Andy Purvis, and Stefan Dullinger
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Science - Abstract
Abstract While the regional distribution of non-native species is increasingly well documented for some taxa, global analyses of non-native species in local assemblages are still missing. Here, we use a worldwide collection of assemblages from five taxa - ants, birds, mammals, spiders and vascular plants - to assess whether the incidence, frequency and proportions of naturalised non-native species depend on type and intensity of land use. In plants, assemblages of primary vegetation are least invaded. In the other taxa, primary vegetation is among the least invaded land-use types, but one or several other types have equally low levels of occurrence, frequency and proportions of non-native species. High land use intensity is associated with higher non-native incidence and frequency in primary vegetation, while intensity effects are inconsistent for other land-use types. These findings highlight the potential dual role of unused primary vegetation in preserving native biodiversity and in conferring resistance against biological invasions.
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- 2023
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97. Effect of xylitol on Porphyromonas gingivalis: A systematic review
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Sau You Chen, Joshua Delacruz, Yong Kim, Roger Kingston, Laura Purvis, and Dileep Sharma
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cytokines ,periodontal disease ,Porphyromonas gingivalis ,xylitol ,Dentistry ,RK1-715 - Abstract
Abstract Objective This review was conducted to assess the effectiveness of xylitol against Porphyromonas gingivalis anaerobic species, a key microbe contributing to periodontal disease pathogenesis. Material and Methods Relevant studies published on seven online databases (Cochrane, Ovid, Pubmed, Pubmed Central, Scopus, Google Scholar, and Web of Science) were included in accordance with the PRISMA guidelines. Inclusion criteria allowed all study designs involving xylitol and P. gingivalis, literature published since the year 2000, and all xylitol delivery forms. Results The initial search yielded 186 papers. After the removal of duplicates, five reviewers screened every article for eligibility and seven articles were selected for data extraction. Four out of seven included studies assessed the dose‐dependent effect of xylitol on P. gingivalis growth, two studies assessed the effect of xylitol on P. gingivalis‐induced cytokine expression, and one study assessed both domains. Conclusions From the in vitro studies included in this systematic review, there is some evidence of xylitol's inhibitory effect on P. gingivalis. However, more evidence derived from in vivo studies is required to confirm its effectiveness warranting their routine use.
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- 2023
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98. Reaching late adopters: factors influencing COVID-19 vaccination of Marshallese and Hispanic adults
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Jennifer L. Vincenzo, Marissa J. Spear, Ramey Moore, Rachel S. Purvis, Susan K. Patton, Jennifer Callaghan-Koru, Pearl A. McElfish, and Geoffrey M. Curran
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Socio-ecological model ,Faith-based ,Community engagement ,Vaccine uptake ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Marshallese and Hispanic communities in the United States have been disproportionately affected by COVID-19. Identifying strategies to reach late vaccine adopters is critical for ongoing and future vaccination efforts. We utilized a community-engaged approach that leveraged an existing community-based participatory research collaborative of an academic healthcare organization and Marshallese and Hispanic faith-based organizations (FBO) to host vaccination events. Methods Bilingual Marshallese and Hispanic study staff conducted informal interviews with 55 participants during the 15-minute post-vaccination observation period and formal semi-structured interviews with Marshallese (n = 5) and Hispanic (n = 4) adults post-event to assess the implementation of community vaccine events at FBOs, with a focus on factors associated with the decision to attend and be vaccinated. Formal interview transcripts were analyzed using thematic template coding categorized with the socio-ecological model (SEM). Informal interview notes were coded via rapid content analysis and used for data triangulation. Results Participants discussed similar factors influencing attitudes and behaviors toward receiving the COVID-19 vaccine. Themes included: (1) intrapersonal – myths and misconceptions, (2) interpersonal – protecting family and family decision-making, (3) community – trust of community location of events and influence of FBO members and leaders, (4) institutional – trust in a healthcare organization and bilingual staff, and (5) policy. Participants noted the advantages of vaccination delivery at FBOs, contributing to their decision to attend and get vaccinated. Conclusions The following strategies may improve vaccine-related attitudes and behaviors of Marshallese and Hispanic communities not only for the COVID-19 vaccine but also for other preventive vaccinations: 1) interpersonal-level – develop culturally-focused vaccine campaigns targeting the family units, 2) community-level – host vaccination events at convenient and/or trusted locations, such as FBOs, and engage community and/or FBO formal or lay leaders as vaccine ambassadors or champions, and 3) institutional-level – foster trust and a long-term relationship with the healthcare organization and provide bilingual staff at vaccination events. Future research would be beneficial to investigate the effects of replicating these strategies to support vaccine uptake among Marshallese and Hispanic communities.
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- 2023
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99. Better or different? A reflection on the suitability of indicator methods for a just transition to a circular economy
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Purvis, Ben and Genovese, Andrea
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- 2023
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100. Efficacy and muscle safety assessment of fukutin-related protein gene therapy
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Benasutti, Halli, Maricelli, Joseph W., Seto, Jane, Hall, John, Halbert, Christine, Wicki, Jacqueline, Huesgen, Lydia, Purvis, Nicholas, Regnier, Michael, Lin, David C., Rodgers, Buel D., and Chamberlain, Jeffrey S.
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- 2023
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