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54. Attitudes and Recommendations of Physicians towards Alcohol Consumption and Cardiovascular Health: A Perspective from Argentina

Author

Ricardo Lopez Santi, Sohaib Haseeb, Bryce Alexander, Adrian D′Ovidio, Sergio Gimenez, Carlos Secotaro, Diego Martinez Demaria, Luis Maria Pupi, Sonia Costantini, Daniel Piskorz, Alejandro Amarilla, Alberto Lorenzatti, Narcisa Gutierrez, Wilma Hopman, and Adrian Baranchuk

Subjects
alcohol drinking, health knowledge, physician attitudes, standard drink, wine, Medicine
Abstract

Despite epidemiological findings of improvements in cardiovascular risk factors with a light-to-moderate intake of alcohol, many misconceptions remain regarding alcohol intake and the risks and benefits of consumption. We sought to examine physician attitudes and recommendations regarding alcohol intake in a cohort of Argentine physicians and to establish their sources of knowledge. An online national survey was distributed through the Argentine Federation of Cardiology (FAC) to cardiologists, internal medicine specialists, general and other subspecialty physicians in Argentina. The survey was completed by 745 physicians, of whom 671 (90%) were cardiologists. In total, 35% of physicians viewed moderate alcohol intake to be beneficial for cardiovascular health, 36% believed only wine offered such benefits, 24% viewed any intake to be harmful, and 5% had other opinions. More than half (57%) self-reported their knowledge came from academic sources. Regarding knowledge of drinking guidelines, only 41% of physicians were aware of the concept of “standard drink”. Physicians were generally not comfortable converting standard drinks into other metric units, however men tended to be more comfortable than women (p = 0.052). Physicians were not satisfied with their knowledge of drinking guidelines (3.01 ± 2.73, on a 0–10 scale). Physicians were generally comfortable in counselling patients regarding safe limits of consumption (6.22 ± 3.20, on a 0–10 scale). Argentine physicians were not satisfied with their knowledge of alcohol consumption guidelines or their understanding of the reported metrics. Only one-third of study participants viewed moderate alcohol intake as beneficial for cardiovascular health. This study shows the necessity to optimize the sources of knowledge.

Published
2018
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55. Maternal transmission of Alzheimer's disease: Prodromal metabolic phenotype and the search for genes

Author

Mosconi Lisa, Berti Valentina, Swerdlow Russell H, Pupi Alberto, Duara Ranjan, and de Leon Mony

Subjects
Alzheimer's disease, late onset, maternal transmission, early detection, positron emission tomography, Medicine, Genetics, QH426-470
Abstract

Abstract After advanced age, having a parent affected with Alzheimer's disease (AD) is the most significant risk factor for developing AD among cognitively normal (NL) individuals. Although rare genetic mutations have been identified among the early-onset forms of familial AD (EOFAD), the genetics of the more common forms of late-onset AD (LOAD) remain elusive. While some LOAD cases appear to be sporadic in nature, genetically mediated risk is evident from the familial aggregation of many LOAD cases. The patterns of transmission and biological mechanisms through which a family history of LOAD confers risk to the offspring are not known. Brain imaging studies using 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) have shown that NL individuals with a maternal history of LOAD, but not with a paternal family history, express a phenotype characterised by a pattern of progressive reductions of brain glucose metabolism, similar to that in AD patients. As maternally inherited AD may be associated with as many as 20 per cent of the total LOAD population, understanding the causes and mechanisms of expression of this form of AD is of great relevance. This paper reviews known genetic mutations implicated in EOFAD and their effects on brain chemistry, structure and function; epidemiology and clinical research findings in LOAD, including in vivo imaging findings showing selective patterns of hypometabolism in maternally inherited AD; possible genetic mechanisms involved in maternal transmission of AD, including chromosome X mutations, mitochondrial DNA and imprinting; and genetic mechanisms involved in other neurological disorders with known or suspected maternal inheritance. The review concludes with a discussion of the potential role of brain imaging for identifying endophenotypes in NL individuals at risk for AD, and for directing investigation of potential susceptibility genes for AD.

Published
2010
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56. Massively Multiplayer Online Role-Playing Game (MMORPG) Player Profiles: Exploring Player’s Motives Predicting Internet Addiction Disorder

Author

Virginia Pupi, Giacomo Mancini, Roberta Biolcati, Biolcati R., Pupi V., and Mancini G.

Subjects
media_common.quotation_subject, 030508 substance abuse, Medicine (miscellaneous), 050109 social psychology, Gaming Motivation, Impulsivity, 03 medical and health sciences, medicine, Personality, Sensation seeking, 0501 psychology and cognitive sciences, Big Five personality traits, media_common, Addiction, 05 social sciences, Psychiatry and Mental health, Clinical Psychology, Escapism, Internet addiction disorder, Video Games, Anxiety, medicine.symptom, 0305 other medical science, Psychology, Social psychology, human activities, Internet Addiction Disorder
Abstract

Background: Due to the increasing spread of massively multiplayer online role-playing games (MMORPGs) and their addictive potential, scholars assert that understanding the factors underpinning Internet gaming disorder (IGD) is crucial, considering the psychopathological classification. Objectives: This study aimed to explore the motives predicting IGD in MMORPG players with different personality risk profiles. Materials and Methods: An online survey was conducted among 202 MMORPG players (mean age = 27.85 years, SD = 6.49). A cluster analysis was performed to classify the samples, according to the substance use risk profile scale (SURPS), distinguishing a sensation seeking (SS) group from a group prone to negative emotions (PNE), including anxiety, hopelessness, and impulsivity. Also, the gaming motives, which were determined using the Motives for Online Gaming Questionnaire (MOGQ), were considered as independent variables in analyses. The regression analyses indicated different combinations of gaming motives, predisposing the two groups to IGD. Results: The escapism motive and male gender were the main risk factors for SS players, whereas the sociability motive predicted addiction tendencies in the PNE group. Also, the competition motive was a strong predictor of IGD in both groups; this motive was found to be associated with the male gender and the specific game genre. Moreover, the PNE players were significantly more addicted to MMORPGs and were less satisfied with their life, compared to the SS group. Conclusions: Based on the present results, clustering gamers in terms of personality traits allowed us to understand the mechanisms underlying IGD for overcoming a reductive approach, which considers MMORPG players as a uniform group.

Published
2021

57. The role of video gaming motives in the relationship between personality risk traits and Internet Gaming Disorder

Author

Virginia Pupi, Roberta Biolcati, Stefano Passini, Biolcati, Roberta, Passini, Stefano, and Pupi, Virginia

Subjects
Video gaming, business.industry, media_common.quotation_subject, 030508 substance abuse, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, Clinical Psychology, 0302 clinical medicine, Personality, The Internet, Internet gaming disorder, gaming motives, mediation model, personality risk traits, 0305 other medical science, business, Psychology, Humanities, human activities, media_common
Abstract

The main aim of this study is to improve our knowledge on Internet Gaming Disorder (IGD), contributing to a common discourse concerning its risk profiles. Specifically, the study aims to assess the prevalence of addicted gamers among Italian online and offline gamers, accounting for gender and to investigate the mediation role of gaming motives on the relationship between personality risk traits and IGD. A total of 627 videogame players (55% women; mean age 27 years) recruited from social networking sites took part in the study and filled a questionnaire including gaming characteristics, the Internet Gaming Disorder Scale (IGDS9-SF), the Substance Use Risk Profile Scale (SURPS) and the Motives for Online Gaming Questionnaire (MOGQ). The prevalence rate of Internet gaming disorder was 5.3%. Hopelessness was the personality dimension that most differentiates gaming addicts from non-addicts. Results of the mediation model suggested that Hopelessness was both directly and indirectly (via escape, fantasy and recreational motives) associated with IGD. The motivations Escape and Fantasy also mediate between Anxiety sensitivity and IGD while Competition mediate between Sensation seeking trait and IGD. The evidence suggests that IGD is motivated by psychological mechanisms similar to those compelling substance abuse, but with its own unique features.RésuméCette étude a pour but d’améliorer notre connaissance de la dépendance au jeu sur Internet (DJI) afin d’enrichir le discours sur ses profils de risque. Elle vise plus précisément à évaluer la prévalence des joueurs dépendants parmi les joueurs italiens en ligne et hors ligne, en tenant compte du genre et en examinant le rôle de médiation des raisons qui motivent la pratique des jeux dans la relation entre les traits de personnalité présentant des risques et la DJI. En tout, 627 joueurs de jeux vidéo (55 % de femmes d’une moyenne d’âge de 27 ans) recrutés sur des sites de réseaux sociaux ont participé à l’étude et rempli un questionnaire comprenant des caractéristiques liées au jeu, l’échelle de la dépendance au jeu sur Internet (IGDS9-SF), l’échelle de profil de risque de consommation de substances psychoactives (SURPS) et le questionnaire sur les raisons de jouer en ligne (MOGQ). Le taux de prévalence de la dépendance au jeu sur Internet s’établissait à 5,3 %. Le désespoir constituait l’aspect de la personnalité qui distinguait le plus les personnes dépendantes au jeu des personnes non dépendantes. Les résultats du modèle de médiation donnaient à penser que le désespoir était associé directement et indirectement (raisons liées à la fuite, à l’imaginaire et aux loisirs) à la DJI. Les raisons Fuite et Imaginaire assurent la médiation entre la sensibilité à l’anxiété et la DJI, tandis que la concurrence assure la médiation entre la recherche de sensations et la DJI. Tout indique que la DJI est motivée par des mécanismes psychologiques similaires à ceux qui incitent à la toxicomanie, mais possède ses propres caractéristiques.

Published
2021

65. Cerebral amyloid load determination in a clinical setting: interpretation of amyloid biomarker discordances aided by tau and neurodegeneration measurements

Author

Nerattini, Matilde, primary, Rubino, Federica, additional, Arnone, Annachiara, additional, Polito, Cristina, additional, Mazzeo, Salvatore, additional, Lombardi, Gemma, additional, Puccini, Giulia, additional, Nacmias, Benedetta, additional, De Cristofaro, Maria Teresa, additional, Sorbi, Sandro, additional, Pupi, Alberto, additional, Sciagrà, Roberto, additional, Bessi, Valentina, additional, and Berti, Valentina, additional

Published
2021
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68. Clinical and neuroimaging profiles to identify C9orf72 ‐FTD patients and serum Neurofilament to monitor the progression and the severity of the disease

Author

Giulia Lucidi, Gemma Lombardi, Sandro Sorbi, Andrea Ginestroni, Benedetta Nacmias, Valentina Berti, Silvia Bagnoli, Camilla Ferrari, Valentina Bessi, Irene Piaceri, Alberto Pupi, and Cristina Polito

Subjects
Oncology, 18FDG-PET, C9orf72, frontotemporal dementia, neurofilament light chain, neuropsychology, medicine.medical_specialty, Neurofilament, business.industry, Neuropsychology, Disease, medicine.disease, Neurology, Neuroimaging, Internal medicine, medicine, Neurology (clinical), 18fdg pet, business, Frontotemporal dementia
Published
2019
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72. Cerebral amyloid load determination in a clinical setting: interpretation of amyloid biomarker discordances aided by tau and neurodegeneration measurements

Author

Alberto Pupi, Matilde Nerattini, Giulia Puccini, Roberto Sciagrà, Salvatore Mazzeo, Gemma Lombardi, Federica Rubino, Benedetta Nacmias, Valentina Berti, Cristina Polito, Valentina Bessi, Maria Teresa De Cristofaro, Sandro Sorbi, and Annachiara Arnone

Subjects
Pathology, medicine.medical_specialty, Amyloid, Precuneus, tau Proteins, Dermatology, Cerebrospinal fluid, Alzheimer Disease, medicine, Dementia, Humans, Cognitive Dysfunction, Retrospective Studies, Fluorodeoxyglucose, Amyloid beta-Peptides, medicine.diagnostic_test, business.industry, Alzheimer’s disease, Biomarkers, Plaque, Amyloid, Positron emission tomography, General Medicine, medicine.disease, Peptide Fragments, Psychiatry and Mental health, medicine.anatomical_structure, Posterior cingulate, Positron-Emission Tomography, Biomarker (medicine), Neurology (clinical), business, medicine.drug
Abstract

BACKGROUND Alzheimer's disease (AD) diagnosis can be hindered by amyloid biomarkers discordances. OBJECTIVE We aim to interpret discordances between amyloid positron emission tomography (Amy-PET) and cerebrospinal fluid (CSF) (Aβ42 and Aβ42/40), using Amy-PET semiquantitative analysis, [18F]fluorodeoxyglucose (FDG)-PET pattern, and CSF assays. METHOD Thirty-six subjects with dementia or mild cognitive impairment, assessed by neuropsychological tests, structural and functional imaging, and CSF assays (Aβ42, Aβ42/40, p-tau, t-tau), were retrospectively examined. Amy-PET and FDG-PET scans were analyzed by visual assessment and voxel-based analysis. SUVR were calculated on Amy-PET scans. RESULTS Groups were defined basing on the agreement among CSF Aβ42 (A), CSF Aβ42/40 Ratio (R), and Amy-PET (P) dichotomic results ( ±). In discordant groups, CSF assays, Amy-PET semiquantification, and FDG-PET patterns supported the diagnosis suggested by any two agreeing amyloid biomarkers. In groups with discordant CSF Aβ42, the ratio always agrees with Amy-PET results, solving both false-negative and false-positive Aβ42 results, with Aβ42 levels close to the cut-off in A + R-P- subjects. The A + R + P- group presented high amyloid deposition in relevant areas, such as precuneus, posterior cingulate cortex (PCC) and dorsolateral frontal inferior cortex at semiquantitative analysis. CONCLUSION The amyloid discordant cases could be overcome by combining CSF Aβ42, CSF ratio, and Amy-PET results. The concordance of any 2 out of the 3 biomarkers seems to reveal the remaining one as a false result. A cut-off point review could avoid CSF Aβ42 false-negative results. The regional semiquantitative Amy-PET analysis in AD areas, such as precuneus and PCC, could increase the accuracy in AD diagnosis.

Published
2021

73. KINERJA DINAS KESEHATAN KABUPATEN PASAMAN DALAM UPAYA MENANGANI STUNTING DI KABUPATEN PASAMAN

Author

Armila, Pupi Aprila

Subjects
JS Local government Municipal government
Abstract

Penelitian ini bertujuan untuk mendeskripsikan kinerja Dinas Kesehatan Kabupaten Pasaman dalam upaya menangani stunting di Kabupaten Pasaman. Penelitian ini dilatarbelakangi oleh tingginya angka prevalensi stunting di Kabupaten Pasaman dengan pravelansi 40.6%. Oleh sebab itu, Kabupaten Pasaman menjadi kabupaten prioritas dalam upaya menangani stunting. Kemudian, Dinas Kesehatan berperan sebagai leading sektor dalam penaggulangan stunting terutama dalam penanggulangan stunting secara lansung. Penelitian ini menggunakan teori kinerja menurut Mahmudi yang terdiri dari faktor individu, faktor kepemimpinan, faktor tim, faktor sistem, dan faktor kontekstual. Metode yang digunakan dalam penelitian ini adalah metode kualitatif deskriptif. Teknik dalam mengumpulkan data menggunakan wawancara dan dokumentasi. Teknik keabsahan data menggunakan triangulasi sumber. Pemilihan informan menggunakan teknik purposive sumpling. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa kinerja Dinas Kesehatan Kabupaten Pasaman dalam upaya menangani stunting di Kabupaten Pasaman sudah cukup baik. Meskipun masih ada beberapa kendala yang dirasakan. Belum mencukupinya Antropometri Kit yakni alat yang digunakan untuk pengukuran balita sesuai standar WHO. Masih kurangnya komitmen kecamatan/nagari lokus stunting dalam penanganan stunting. Pada proses organisasi dalam pelaksanaan kegiatan di Posyandu masih kurangnya keinginan masyarakat untuk datang ke posyandu membuat beberapa indikator kegiatan gizi tidak mencapai target. Kemudian dalam kontekstual, faktor sosial budaya dan ekonomi yang masih kurang menjadi penyebab masih susahnya menurunkan angka stunting.

Published
2021

77. Ent-it-UP

Author

Pupi, Sara, primary, Di Pietro, Giulia, additional, and Aliprandi, Carlo, additional

Published
2014
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94. Cyber dating abuse and ghosting behaviours: personality and gender roles in romantic relationships.

Author

Biolcati, Roberta, Pupi, Virginia, and Mancini, Giacomo

Subjects
*DATING violence, *GENDER role, *CYBERBULLYING, *PERSONALITY, *PSYCHOLOGICAL factors, *GENDER differences (Psychology), *EMOTIONAL stability
Abstract

BACKGROUND Cyber dating abuse (CDA) refers to physical, verbal, and psychological violence perpetrated towards a romantic partner via technology and social media. Another emerging form of online abuse is ghosting, a silent strategy to dissolve undesired relationships without openly having to break them up. The aims of the current study were (i) to explore the relationship between CDA and ghosting behaviours in romantic relationships and (ii) to investigate the roles of gender and personality traits (conscientiousness, agreeableness, extraversion, emotional stability, openness) in prediction of CDA (perpetration and victimization). PARTICIPANTS AND PROCEDURE A sample of 409 participants (64.8% females), aged between 18 and 53 years (Mage = 26.40, SD = 6.06), took part in the study. RESULTS. CDA and ghosting behaviours are interrelated, and women were more prone than men were to use ghosting strategies, such as stopping messages abruptly and punishing the partner through silence. Moreover, gender and personality traits differently predicted direct aggression and control/monitoring perpetration and direct aggression victimization, but they were not significant predictors of control/monitoring victimization. CONCLUSIONS The findings are discussed in light of gender differences to improve our understanding of the psychological factors involved in cyber dating violence. [ABSTRACT FROM AUTHOR]

Published
2022
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99. KOMUNIKASI PEMBANGUNAN DALAM PEMBERDAYAAN MASYARAKAT MENUJU DESA UNGGUL DAN MANDIRI

Author

Barick Ahmad Setiawan, Adi Permana Sidik, Nunung Sanusi, Tatang Sudrajat, Hersusetiyati Hersusetiyati, Yuyun Yuniarsih, Widyapuri Prasastiningtyas, Sandra Irawaty, Deni Nurdyana Hadimin, Witri Cahyati, Fauzan Aziz, Roni Tabroni, Muhammad Dadi Priadi, Hayun Setiawan, Abdurrahman Rahim Thaha, Yadiman Yadiman, Pupi Indriarti Zaelani, and Reza Saeful Rachman

Abstract

Dalam rangka mewujudkan desa unggul dan mandiri pemerintahan desa perlu mempersiapkan sumber daya manusia yang unggul dari mulai pimpinan pemerintah desa, aparat desa dan seluruh masyarakat desa. Untuk mewujudkan hal tersebut diantaranya dapat dilakukan melalui proses komunikasi pembangunan. Komunikasi pembangunan merupakan proses penyampaian materi dalam rangka meningkatkan sesuatu agar menjadi lebih baik. Secara luas pengertian komunikasi pembangunan adalah sebagai aktivitas pertukaran pesan secara timbal balik diantara semua pihak yang terlibat dalam usaha pembangunan, terutama masyarakat dan pemerintah, sejak dari proses perencanaan, pelaksanaan dan penilaian terhadap pembangunan. Kegiatan yang dilakukan oleh Fakultas Ilmu Komunikasi dan Administrasi Bisnis (FIKA) dalam rangka pemberdayaan masyarakat menuju desa unggul dan mandiri diantaranya dengan pemberian materi yang di berikan oleh para dosen FIKA selaku narasumber dalam kegiatan tersebut. Kegiatan yang dilakukan merupakan bagian dari tridharma perguruan tinggi yaitu pengabdian kepada masyarakat atau PKM.

Published
2020
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100. Challenges in Alzheimer's Disease Diagnostic Work-Up: Amyloid Biomarker Incongruences

Author

Valentina Berti, Silvia Bagnoli, Camilla Ferrari, Alberto Pupi, Sonia Padiglioni, Irene Piaceri, Valentina Bessi, Sandro Sorbi, Cristina Polito, Benedetta Nacmias, Maria Teresa De Cristofaro, Giulia Lucidi, and Gemma Lombardi

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Amyloid, Concordance, Pilot Projects, tau Proteins, Disease, Neuropsychological Tests, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Alzheimer Disease, Internal medicine, Medicine, Dementia, Humans, Aged, Retrospective Studies, Amyloid beta-Peptides, business.industry, General Neuroscience, Neuropsychology, General Medicine, Middle Aged, medicine.disease, Work-up, Peptide Fragments, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Cross-Sectional Studies, Positron-Emission Tomography, Biomarker (medicine), Female, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Biomarkers
Abstract

Background: Discordance among amyloid biomarkers is a challenge to overcome in order to increase diagnostic accuracy in dementia. Objectives: 1) To verify that cerebrospinal fluid (CSF) Aβ42/Aβ40 ratio (AβR) better agrees with Amyloid PET (Amy-PET) results compared to CSF Aβ42; 2) to detect differences among concordant positive, concordant negative, and discordant cases, basing the concordance definition on the agreement between CSF AβR and Amy-PET results; 3) to define the suspected underlying pathology of discordant cases using in vivo biomarkers. Method: We retrospectively enrolled 39 cognitively impaired participants in which neuropsychological tests, apolipoprotein E genotype determination, TC/MRI, FDG-PET, Amy-PET, and CSF analysis had been performed. In all cases, CSF analysis was repeated using the automated Lumipulse method. In discordant cases, FDG-PET scans were evaluated visually and using automated classifiers. Results: CSF AβR better agreed with Amy-PET compared to CSF Aβ42 (Cohen’s K 0.431 versus 0.05). Comparisons among groups did not show any difference in clinical characteristics except for age at symptoms onset that was higher in the 6 discordant cases with abnormal CSF AβR values and negative Amy-PET (CSF AβR+/AmyPET–). FDG-PET and all CSF markers (Aβ42, AβR, p-Tau, t-Tau) were suggestive of Alzheimer’s disease (AD) in 5 of these 6 cases. Conclusion: 1) CSF AβR is the CSF amyloid marker that shows the better level of agreement with Amy-PET results; 2) The use of FDG-PET and CSF-Tau markers in CSFAβR+/Amy-PET–discordant cases can support AD diagnosis; 3) Disagreement between positive CSF AβR and negative Amy-PET in symptomatic aged AD patients could be due to the variability in plaques conformation and a negative Amy-PET scan cannot be always sufficient to rule out AD.

Published
2020

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