411 results on '"Portoghese, Philip S."'
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52. Targeting Putative Mu Opioid/Chemokine Receptor Type 5 Heteromers Potently Attenuates Nociception in a Murine Model of Sickle Cell Disease
53. Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)
54. Synthesis and activity profiles of bivalent [Leu5]enkephalin-α-oxymorphamine hybrid opioid receptor ligands
55. Targeting the Brain’s Immune System: A Psychopharmacological Approach to Central Nervous System Infections
56. Stereochemical requirements for receptor recognition of the μ-opioid peptide endomorphin-1: Biological activity, NMR and conformational analysis of D-amino acid substituted analogs
57. Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects
58. A bivalent ligand (KMN-21) antagonist for μ/κ heterodimeric opioid receptors
59. Stereospecific synthesis of pseudocodeine: (2,3)-sigmatropic rearrangement using selenium intermediates
60. Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance
61. An Immunocytochemical-Derived Correlate for Evaluating the Bridging of Heteromeric Mu-Delta Opioid Protomers by Bivalent Ligands
62. Reduced Antinociception of Opioids in Rats and Mice by Vaccination with Immunogens Containing Oxycodone and Hydrocodone Haptens
63. Clinically Employed Opioid Analgesics Produce Antinociception via μ-δ Opioid Receptor Heteromers in Rhesus Monkeys
64. The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors
65. Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor
66. MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys
67. Opioid Activity of Spinally Selective Analogues of N-Naphthoyl-β-naltrexamine in HEK-293 Cells and Mice
68. My Farewell to the Journal of Medicinal Chemistry
69. Allosteric Interactions between δ and κ Opioid Receptors in Peripheral Sensory Neurons
70. N -naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers
71. A κ Opioid Pharmacophore Becomes a Spinally Selective κ-δ Agonist When Modified with a Basic Extender Arm
72. ChemInform Abstract: From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes
73. Modulation of Cell Surface Expression of Nonactivated Cholecystokinin Receptors Using Bivalent Ligand-Induced Internalization
74. Internalization of Two Distinct Receptors in Response to Occupation with a Bivalent Ligand Incorporating a Single Stimulus for Internalization
75. Standard Opioid Agonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and [d-Ala2-MePhe4-Glyol5]Enkephalin as Selective μ−δ Agonists
76. Synthesis and in Vitro Characterization of Radioiodinatable Benzodiazepines Selective for Type 1 and Type 2 Cholecystokinin Receptors
77. Revision of Purity Criteria for Tested Compounds
78. Induced Association of μ Opioid (MOP) and Type 2 Cholecystokinin (CCK2) Receptors by Novel Bivalent Ligands
79. Morphine Tolerance in Mice Changes Response of Heroin from μ to δ Opioid Receptors
80. o-Naphthalenedicarboxaldehyde Derivative of 7‘-Aminonaltrindole as a Selective δ-Opioid Receptor Affinity Label
81. Selectivity of δ- and κ-Opioid Ligands Depends on the Route of Central Administration in Mice
82. Synthesis and 124I‐labeling of m‐iodophenylpyrrolomorphinan as a potential PET imaging agent for delta opioid (DOP) receptors
83. The State of the Journal at Its 50th Publication Volume
84. N1'-(p-[18F]Fluorobenzyl)naltrindole (p-[18F]BNTI) as a potential PET imaging agent for DOP receptors
85. Interaction of Bivalent Ligand KDN21 with Heterodimeric δ-κ Opioid Receptors in Human Embryonic Kidney 293 Cells
86. Homology Modeling and Molecular Dynamics Simulations of the Mu Opioid Receptor in a Membrane–Aqueous System
87. Specific Cross-Linking of Lys233 and Cys235 in the Mu Opioid Receptor by a Reporter Affinity Label
88. Comparison of Peptidic and Nonpeptidic δ-Opioid Agonists on Guanosine 5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) Binding in Brain Slices from Sprague-Dawley Rats
89. A Bivalent Ligand (KDAN-18) Containing δ-Antagonist and κ-Agonist Pharmacophores Bridges δ2 and κ1 Opioid Receptor Phenotypes
90. A Bivalent Ligand (KDN-21) Reveals Spinal δ and κ Opioid Receptors Are Organized as Heterodimers That Give Rise to δ1 and κ2 Phenotypes. Selective Targeting of δ−κ Heterodimers
91. Characterization of Specific Opioid Binding Sites in Neural Membranes from the Myenteric Plexus of Porcine Small Intestine
92. Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
93. Naphthalene Dicarboxaldehyde as an Electrophilic Fluorogenic Moiety for Affinity Labeling: Application to Opioid Receptor Affinity Labels with Greatly Improved Fluorogenic Properties
94. Methadone and Heroin Antinociception: Predominant £-Opioid-Receptor Responses in Methadone-Tolerant Mice
95. 2000 Alfred Burger Award Address in Medicinal Chemistry. From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes.
96. Molecular recognition at kappa opioid receptors
97. ChemInform Abstract: Affinity Labels as Tools for the Identification of Opioid Receptor Recognition Sites
98. Transformation of a κ-Opioid Receptor Antagonist to a κ-Agonist by Transfer of a Guanidinium Group from the 5‘- to 6‘-Position of Naltrindole
99. From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes
100. κ-Opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes
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