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53. Clinico-Pathological Features Influencing the Prognostic Role of Body Mass Index in Patients With Advanced Renal Cell Carcinoma Treated by Immuno-Oncology Combinations (ARON-1)

Author

Santoni, Matteo, Massari, Francesco, Myint, Zin W., Iacovelli, Roberto, Pichler, Martin, Basso, Umberto, Kopecky, Jindrich, Kucharz, Jakub, Buti, Sebastiano, Salfi, Alessia, Büttner, Thomas, De Giorgi, Ugo, Kanesvaran, Ravindran, Fiala, Ondřej, Grande, Enrique, Zucali, Paolo Andrea, Fornarini, Giuseppe, Bourlon, Maria T, Scagliarini, Sarah, Molina-Cerrillo, Javier, Aurilio, Gaetano, Matrana, Marc R, Pichler, Renate, Cattrini, Carlo, Büchler, Tomas, Seront, Emmanuel, Calabrò, Fabio, Pinto, Alvaro, Berardi, Rossana, Zgura, Anca, Mammone, Giulia, Ansari, Jawaher, Atzori, Francesco, Chiari, Rita, Zakopoulou, Roubini, Caffo, Orazio, Procopio, Giuseppe, Bassanelli, Maria, Zampiva, Ilaria, Messina, Carlo, Küronya, Zsófia, Mosca, Alessandra, Bhuva, Dipen, Vau, Nuno, Incorvaia, Lorena, Rebuzzi, Sara Elena, Roviello, Giandomenico, Zabalza, Ignacio Ortego, Rizzo, Alessandro, Mollica, Veronica, Catalini, Ilaria, Monteiro, Fernando Sabino M., Montironi, Rodolfo, Battelli, Nicola, Rizzo, Mimma, and Porta, Camillo

Published
2023
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54. Correlation Between Immune-related Adverse Event (IRAE) Occurrence and Clinical Outcome in Patients With Metastatic Renal Cell Carcinoma (mRCC) Treated With Nivolumab: IRAENE Trial, an Italian Multi-institutional Retrospective Study

Author

Vitale, Maria Giuseppa, Pipitone, Stefania, Venturelli, Marta, Baldessari, Cinzia, Porta, Camillo, Iannuzzi, Federica, Basso, Umberto, Scagliarini, Sarah, Zucali, Paolo Andrea, Galli, Luca, Rossetti, Sabrina, Caserta, Claudia, Bracarda, Sergio, Iacovelli, Roberto, Masini, Cristina, Cortellini, Alessio, Di Girolamo, Stefania, Buti, Sebastiano, Fornarini, Giuseppe, Carrozza, Francesco, Santoni, Matteo, Caputo, Francesco, Giaquinta, Stefania, Balduzzi, Sara, D’Amico, Roberto, Vitale, Giovanna, Mighali, Pasquale, and Sabbatini, Roberto

Published
2020
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55. Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial

Author

Park, Se Hoon, van der Heijden, Michiel S., Necchi, Andrea, Castellano, Daniel, Bamias, Aristotelis, Lee, Jae Lyun, De Giorgi, Ugo, Bögemann, Martin, Eigl, Bernhard J., Tsiatas, Marinos, Powles, Thomas, Novikov, Andrey, Skoneczna, Iwona, Mukherjee, Som D., Suarez, Cristina, Westgeest, Hans, Fradet, Yves, Flechon, Aude, Ou, Yen-Chuan, Park, Inkeun, Matveev, Vsevolod, Pérez-Valderrama, Begoña, Cheng, Susanna, Frank, Stephen, Gurney, Howard, Anido, Urbano, Hamzaj, Alketa, Retz, Margitta, Sridhar, Srikala, Scagliotti, Giorgio Vittorio, Voortman, Jens, Alekseev, Boris, Alyasova, Anna, Komyakov, Boris, Dumez, Herlinde, Pavic, Michel, Kimura, Go, Mizokami, Atsushi, Osanto, Susanne, Arranz, Jose Angel, Piersma, Djura, Shin, Sang Joon, Karyakin, Oleg, Delgado, Ignacio, Gonzalez, Jose Luis, Pang, See-Tong, Tran, Anna, Lipatov, Oleg, Su, Wen-Pin, Flaig, Thomas, Alva, Ajjai, Park Kyong, Hwa, Kopyltsov, Evgeny, Almagro, Elena, Domenech, Monserrat, Chang, Yen-Hwa, Sautois, Brieuc, Ravaux, Andre, Aravantinos, Gerasimos, Georgoulias, Vasileios, Mulder, Sasja, Kim, Yu Jung, Kater, Fabio, Chevreau, Christine, Tagawa, Scott, Zalewski, Pawel, Joly, Florence, Loriot, Yohann, Hatiboglu, Gencay, Gianni, Luca, Morelli, Franco, Tambaro, Rosa, Hashimoto, Yasuhiro, Nosov, Alexander, Font, Albert, Rodriguez-Vida, Alejo M., Jones, Robert, Vasudev, Naveen, Srinivas, Sandhya, Zhang, Jingsong, Gil, Thierry, Finch, Daygen, Grimm, Marc-Oliver, Su, Yu-Li, Chowdhury, Simon, Hocking, Christopher, Plas, Eugen, North, Scott, Jensen, Niels Viggo, Theodore, Christine, Imkamp, Florian, Peer, Avivit, Kobayashi, Takashi, Sakai, Hideki, Sassa, Naoto, Yoshimura, Kazuhiro, Aarts, Maureen, Ferreira Castro, Ana, Topuzov, Marlen, Rodriguez, Juan Francisco, Vazquez, Federico Jose, Tsai, Yu-Chieh, Crabb, Simon, Hussain, Syed, Bendell, Johanna, Gross-Goupil, Marine, Gwenaelle, Gravis, Berger, Raanan, Statsenko, Galina, Evans, Linda, Drakaki, Alexandra, Somer, Bradley, Davis, Ian, Lynam, James, Borges, Giuliano, Dettino, Aldo, Fay, André P., Martins, Graziella, Zucca, Luis Eduardo, Agerbaek, Mads, Kalofonos, Haralambos, Rosenbaum, Eli, Enokida, Hideki, Kikukawa, Hiroaki, Nishimura, Kazuo, Tamada, Satoshi, Uemura, Motohide, Lopez, Yamil, Gietema, Jourik, Slojewski, Marcin, Fernandes, Isabel, Smolin, Alexey, Mazhar, Danish, Kalebasty, Arash Rezazadeh, Carthon, Bradley, Loidl, Wolfgang, Franke, Fabio, Girotto, Gustavo, Alimohamed, Nimira, Macfarlane, Robyn, Pappot, Helle, Niegisch, Guenter, Mavroudis, Dimitrios, Sella, Avishay, Porta, Camillo, Ebara, Shin, Nakamura, Motonobu, Obara, Wataru, Okuno, Norihiko, Shinohara, Nobuo, Sugimoto, Mikio, Suzuki, Akitaka, Tokuda, Noriaki, Uemura, Hiroji, Yamaguchi, Akito, Ramirez, Francisco, Rozanowski, Pawel, Wiechno, Pawel, Keam, Bhumsuk, Kislov, Nikolay, Plaksin, Denis, Cicin, Irfan, Kumar, Satish, Galsky, Matthew D., Petrylak, Daniel P., Rosales, Joseph, Vaishampayan, Ulka, Culine, Stephane, Papandreou, Christos, Nara, Taketoshi, Erman, Mustafa, Kreiger, Laurence, Janoski, Juliana, Rosa, Diogo, Siqueira, Mariana, Canil, Christina, Sengelov, Lisa, Tourani, Jean-Marc, Arai, Gaku, Hashine, Katsuyoshi, Kawakita, Mutsushi, Nakaigawa, Noboru, Nomi, Hayahito, Shiina, Hiroaki, Suzuki, Hiroyoshi, Yonese, Junji, Kuri, Roberto, Macedo, Eleazar, Rivera, Samuel, Villalobos Prieto, Alberto, Polakiewicz-Gilowska, Anna, Zaucha, Renata, Lopes, Fabio, Ponomarev, Roman, Pomerantz, Mark, Shariat, Shahrokh, Luk, Cynthia, Lesniewski-Kmak, Krzysztof, van der Heijden, Michiel S, Galsky, Matthew D, Petrylak, Daniel P, Ogawa, Osamu, Lee, Jae-Lyun, Eigl, Bernhard J, Mukherjee, Som D, Suárez, Cristina, Fay, André P, Duran, Ignacio, Wildsmith, Sophie, He, Philip, Angra, Natasha, Gupta, Ashok K, Levin, Wendy, and Bellmunt, Joaquim

Published
2020
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56. KDIGO Controversies Conference on onco-nephrology: kidney disease in hematological malignancies and the burden of cancer after kidney transplantation

Author

Abu-Alfa, Ali K., Amer, Hatem, Beutel, Gernot, Chapman, Jeremy, Chen, Xiaohong, Chudek, Jerzy, Cosmai, Laura, Danesi, Romano, De Stefano, Filippo, Iseki, Kunitoshi, Jaimes, Edgar A., Jhaveri, Kenar D., Jurczyszyn, Artur, Kazancioğlu, Rümeyza, Kitchlu, Abhijat, Kollmannsberger, Christian, Lahoti, Amit, Li, Yang, Macía, Manuel, Matsubara, Takeshi, Mitropoulos, Dionysios, Noiri, Eisei, Perazella, Mark A., Ronco, Pierre, Rosner, Mitchell H., Soler Romeo, Maria Jose, Sprangers, Ben, Stadler, Walter M., Stevens, Paul E., Tesař, Vladimír, Torres da Costa e Silva, Verônica, Vesole, David H., Vijayan, Anitha, Viklický, Ondřej, Workeneh, Biruh T., Yanagita, Motoko, Zakharova, Elena, Małyszko, Jolanta, Bamias, Aristotelis, Danesh, Farhad R., Dębska-Ślizień, Alicja, Gallieni, Maurizio, Gertz, Morie A., Kielstein, Jan T., Tesarova, Petra, Wong, Germaine, Cheung, Michael, Wheeler, David C., Winkelmayer, Wolfgang C., and Porta, Camillo

Published
2020
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58. KDIGO Controversies Conference on onco-nephrology: understanding kidney impairment and solid-organ malignancies, and managing kidney cancer

Author

Abu-Alfa, Ali K., Amer, Hatem, Beutel, Gernot, Chapman, Jeremy, Chen, Xiaohong, Chudek, Jerzy, Cosmai, Laura, Danesi, Romano, De Stefano, Filippo, Iseki, Kunitoshi, Jaimes, Edgar A., Jhaveri, Kenar D., Jurczyszyn, Artur, Kazancioğlu, Rümeyza, Kitchlu, Abhijat, Kollmannsberger, Christian, Lahoti, Amit, Li, Yang, Macía, Manuel, Matsubara, Takeshi, Mitropoulos, Dionysios, Noiri, Eisei, Perazella, Mark A., Ronco, Pierre, Rosner, Mitchell H., Soler Romeo, Maria Jose, Sprangers, Ben, Stadler, Walter M., Stevens, Paul E., ladimír Tesař, Torres da Costa e Silva, Verônica, Vesole, David H., Vijayan, Anitha, Viklický, Ondřej, Workeneh, Biruh T., Yanagita, Motoko, Zakharova, Elena, Porta, Camillo, Bamias, Aristotelis, Danesh, Farhad R., Dębska-Ślizień, Alicja, Gallieni, Maurizio, Gertz, Morie A., Kielstein, Jan T., Tesarova, Petra, Wong, Germaine, Cheung, Michael, Wheeler, David C., Winkelmayer, Wolfgang C., and Małyszko, Jolanta

Published
2020
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60. Synchronous Versus Metachronous Metastatic Disease: Impact of Time to Metastasis on Patient Outcome—Results from the International Metastatic Renal Cell Carcinoma Database Consortium

Author

Donskov, Frede, Xie, Wanling, Overby, Anders, Wells, J. Connor, Fraccon, Anna P., Sacco, Cosimo S., Porta, Camillo, Stukalin, Igor, Lee, Jae-Lyun, Koutsoukos, Konstantinos, Yuasa, Takeshi, Davis, Ian D., Pezaro, Carmel, Kanesvaran, Ravindran, Bjarnason, Georg A., Sim, Hao-Wen, Rathi, Nityam, Kollmannsberger, Christian K., Canil, Christina M., Choueiri, Toni K., and Heng, Daniel Y.C.

Published
2020
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61. Comprehensive analysis of 34 MiT family translocation renal cell carcinomas and review of the literature: investigating prognostic markers and therapy targets

Author

Caliò, Anna, Brunelli, Matteo, Segala, Diego, Pedron, Serena, Remo, Andrea, Ammendola, Serena, Munari, Enrico, Pierconti, Francesco, Mosca, Alessandra, Bollito, Enrico, Sidoni, Angelo, Fisogni, Simona, Sacco, Cosimo, Canu, Luisa, Sentinelli, Steno, Fraccon, Anna Paola, Fiorentino, Michelangelo, Scott, Cathryn, Milella, Michele, Porta, Camillo, Argani, Pedram, and Martignoni, Guido

Published
2020
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63. Nivolumab plus ipilimumab versus sunitinib for first-line treatment of advanced renal cell carcinoma: extended 4-year follow-up of the phase III CheckMate 214 trial

Author

Albiges, Laurence, Tannir, Nizar M., Burotto, Mauricio, McDermott, David, Plimack, Elizabeth R., Barthélémy, Philippe, Porta, Camillo, Powles, Thomas, Donskov, Frede, George, Saby, Kollmannsberger, Christian K., Gurney, Howard, Grimm, Marc-Oliver, Tomita, Yoshihiko, Castellano, Daniel, Rini, Brian I., Choueiri, Toni K., Saggi, Shruti Shally, McHenry, M. Brent, and Motzer, Robert J.

Published
2020
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66. Long-Term Survival in Patients With Relapsed/Refractory Advanced Renal Cell Carcinoma Treated With Tivozanib: Analysis of the Phase III TIVO-3 Trial

Author

Beckermann, Kathryn E, primary, Asnis-Alibozek, Aviva G, additional, Atkins, Michael B, additional, Escudier, Bernard, additional, Hutson, Thomas E, additional, Kasturi, Vijay, additional, McDermott, David F, additional, Pal, Sumanta K, additional, Porta, Camillo, additional, Rini, Brian I, additional, and Verzoni, Elena, additional

Published
2024
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72. Cytoreductive Nephrectomy in Metastatic Papillary Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium

Author

Graham, Jeffrey, Wells, J. Connor, Donskov, Frede, Lee, Jae Lyun, Fraccon, Anna, Pasini, Felice, Porta, Camillo, Bowman, I. Alex, Bjarnason, Georg A., Ernst, D. Scott, Rha, Sun Young, Beuselinck, Benoit, Hansen, Aaron, North, Scott A., Kollmannsberger, Christian K., Wood, Lori A., Vaishampayan, Ulka N., Pal, Sumanta K., Choueiri, Toni K., and Heng, Daniel Y.C.

Published
2019
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74. Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial

Author

Motzer, Robert J, Rini, Brian I, McDermott, David F, Arén Frontera, Osvaldo, Hammers, Hans J, Carducci, Michael A, Salman, Pamela, Escudier, Bernard, Beuselinck, Benoit, Amin, Asim, Porta, Camillo, George, Saby, Neiman, Victoria, Bracarda, Sergio, Tykodi, Scott S, Barthélémy, Philippe, Leibowitz-Amit, Raya, Plimack, Elizabeth R, Oosting, Sjoukje F, Redman, Bruce, Melichar, Bohuslav, Powles, Thomas, Nathan, Paul, Oudard, Stéphane, Pook, David, Choueiri, Toni K, Donskov, Frede, Grimm, Marc-Oliver, Gurney, Howard, Heng, Daniel Y C, Kollmannsberger, Christian K, Harrison, Michael R, Tomita, Yoshihiko, Duran, Ignacio, Grünwald, Viktor, McHenry, M Brent, Mekan, Sabeen, and Tannir, Nizar M

Published
2019
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76. Renal Cancer

Author

Incorvaia, Lorena, primary, Procopio, Giuseppe, additional, and Porta, Camillo, additional

Published
2021
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79. Renal biopsy in the era of immune-based combination therapies for metastatic renal cell carcinoma: Current practices and considerations

Author

Pirovano, Marta, Re Sartò, Giulia Vanessa, Ganini, Carlo, Cosmai, Laura, and Porta, Camillo

Abstract

The rise of immune-based combination therapies has revolutionized the treatment landscape for metastatic renal cell carcinoma (mRCC), offering significant improvements in response rates and survival. However, along with these advancements come challenges in managing treatment-related adverse events, particularly renal toxicities. Kidney biopsies represent the gold standard in diagnosing and managing these complications, providing insights into histopathological patterns and guiding therapeutic strategies. It is important to emphasize that in most of the cases expertise in onco-nephrology can enable accurate diagnosis and management of nephrotoxicities, and that in clinical practice, renal biopsy is often not easily feasible. Research efforts are underway to identify biomarkers and imaging techniques that can accurately detect renal damage characteristics without the need for invasive procedures. Promising candidates have been identified; however, validation studies are essential to enhance their effectiveness and integrate them into standard clinical practice. This paper underscores the importance of individualized approaches in managing renal adverse events and calls for further research to improve diagnostic capabilities for acute kidney injury in the context of immune-based combination therapies.

Published
2024
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81. Lenvatinib Plus Pembrolizumab Versus Sunitinib in First-Line Treatment of Advanced Renal Cell Carcinoma: Final Prespecified Overall Survival Analysis of CLEAR, a Phase III Study.

Author

Motzer, Robert J., Porta, Camillo, Eto, Masatoshi, Powles, Thomas, Grünwald, Viktor, Hutson, Thomas E., Alekseev, Boris, Rha, Sun Young, Merchan, Jaime, Goh, Jeffrey C., Lalani, Aly-Khan A., De Giorgi, Ugo, Melichar, Bohuslav, Hong, Sung-Hoo, Gurney, Howard, Méndez-Vidal, María José, Kopyltsov, Evgeny, Tjulandin, Sergei, Gordoa, Teresa Alonso, and Kozlov, Vadim

Published
2024
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82. Management of Adverse Reactions Related to Lenvatinib Plus Pembrolizumab Treatment Among Patients With Renal Cell Carcinoma.

Author

Grünwald, Viktor, Larkin, James, Puente, Javier, Bedke, Jens, and Porta, Camillo

Subjects
PEMBROLIZUMAB, DRUG side effects, RENAL cell carcinoma, HEALTH outcome assessment, DRUG efficacy
Abstract

Renal cell carcinoma is the predominant histological type of kidney cancer with historically poor patient outcomes. Lenvatinib in combination with pembrolizumab is an approved first-line regimen for people with advanced renal cell carcinoma that showed clinically meaningful improvements in efficacy over sunitinib in the CLEAR trial; however, reduced patient exposure to treatment (often stemming from adverse reactions) is a potential therapeutic barrier that must be addressed. Here, we present management strategies for adverse reactions associated with this treatment combination: fatigue, diarrhea, musculoskeletal pain, hypertension, stomatitis, decreased appetite, rash, nausea, and proteinuria. Dosing modification of lenvatinib and pembrolizumab should be made according to the prescribing information for each medication. Clinicians should consider that some adverse reactions, such as diarrhea, may be attributable to lenvatinib, or may be a symptom of immune-related adverse reactions to pembrolizumab (such as colitis). Adverse reactions can generally be managed by: (1) advising the patient on precautionary measures (eg, for stomatitis, practice dental hygiene, avoid irritating foods, and maintain adequate hydration), (2) monitoring for changes in symptoms from baseline (eg, changes in bowel movements, blood pressure or level of fatigue), (3) interrupting/dose reducing lenvatinib or interrupting pembrolizumab, if warranted, and advising the patient to manage their current symptoms via self-care (managing diarrhea with antidiarrheal agents and hydration), and (4) implementing medical interventions (eg, thyroid replacement or antihypertensive therapy) when needed. Through successful management of adverse reactions, oncology clinicians can improve the well-being of their patients and likely enhance adherence rates to treatment with lenvatinib and pembrolizumab. [ABSTRACT FROM AUTHOR]

Published
2024
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83. Systemic Immune-Inflammation Index in Patients Treated With First-Line Immune Combinations for Metastatic Renal Cell Carcinoma: Insights From the ARON-1 Study.

Author

Marques Monteiro, Fernando Sabino, Fiala, Ondřej, Massari, Francesco, Myint, Zin W., Kopecky, Jindrich, Kucharz, Jakub, Büttner, Thomas, Grande, Enrique, Bourlon, Maria Teresa, Molina-Cerrillo, Javier, Pichler, Renate, Buchler, Tomas, Seront, Emmanuel, Ansari, Jawaher, Bamias, Aristotelis, Bhuva, Dipen, Vau, Nuno, Porta, Camillo, Fay, Andre Poisl, and Santoni, Matteo

Subjects
RENAL cell carcinoma, METASTASIS, BIOMARKERS, CANCER immunotherapy, KINASE inhibitors
Abstract

The treatment of metastatic renal cell carcinoma has evolved on last years. Nowadays immune-combinations are the standard treatment in first-line setting. There is no prognostic biomarker for metastatic renal cell carcinoma in the systemic immunotherapy treatment era. Systemic Immune-Inflammation Index is a cheap and readily available prognostic tool to be used in daily clinical practice. Background: Systemic treatment with immune combinations is the gold standard for metastatic renal cell carcinoma (mRCC) worldwide. The systemic immune-inflammation index (SII) is a prognostic marker for several types of malignant neoplasms, including mRCC, in the era of tyrosine kinase inhibitor (TKI) treatment. Data regarding the prognostic value of the SII in patients with mRCC treated with immunotherapy are scarce and controversial. Methods: We retrospectively collected the data of patients with mRCC from 56 centers in 18 countries. SII (Platelet × Neutrophil/Lymphocyte count) was calculated prior to the first systemic treatment and cut-off was defined by a survival receiver operating characteristic (ROC) analysis. The primary objective of our retrospective study was to assess the outcomes of patients treated with first-line immunotherapy. Results: Data from 1034 mRCC patients was collected and included in this analysis. The SII cut-off value was 1265. After a follow-up of 26.7 months, and the overall survival (OS) and progression-free survival (PFS) were 39.8 and 15.7 months, respectively. According to SII (low vs. high), patients with low-SII had longer OS (55.7 vs. 22.2 months, P < .001), better PFS (20.8 vs. 8.5 months, P < .001), and higher overall response rate (52 vs. 37%, P = .033). Conclusion: A high SII is associated with poor oncological outcomes in patients with mRCC. SII could be an easily accessible prognostic indicator for use in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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84. Phase 3 CLEAR study in patients with advanced renal cell carcinoma: outcomes in subgroups for the lenvatinib-plus-pembrolizumab and sunitinib arms.

Author

Grünwald, Viktor, Powles, Thomas, Masatoshi Eto, Kopyltsov, Evgeny, Sun Young Rha, Porta, Camillo, Motzer, Robert, Hutson, Thomas E., José Méndez-Vidal, María, Sung-Hoo Hong, Winquist, Eric, Goh, Jeffrey C., Maroto, Pablo, Buchler, Tomas, Toshio Takagi, Burgents, Joseph E., Perini, Rodolfo, Cixin He, Okpara, Chinyere E., and McKenzie, Jodi

Subjects
SUNITINIB, RENAL cell carcinoma, BONE metastasis, THERAPEUTICS, TREATMENT effectiveness, PROGRESSION-free survival
Abstract

Introduction: The phase 3 CLEAR study demonstrated that lenvatinib plus pembrolizumab significantly improved efficacy versus sunitinib as first-line treatment for patients with advanced renal cell carcinoma (RCC). Prognostic features including presence and/or site of baseline metastases, prior nephrectomy, and sarcomatoid features have been associated with disease and treatment success. This subsequent analysis explores outcomes in patients with or without specific prognostic features. Methods: In CLEAR, patients with clear cell RCC were randomly assigned (1:1:1) to receive either lenvatinib (20 mg/day) plus pembrolizumab (200 mg every 3 weeks), lenvatinib (18 mg/day) plus everolimus (5 mg/day), or sunitinib alone (50 mg/day, 4 weeks on, 2 weeks off). In this report, progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) were all assessed in the lenvatinib-plus-pembrolizumab and the sunitinib arms, based on baseline features: lung metastases, bone metastases, liver metastases, prior nephrectomy, and sarcomatoid histology. Results: In all the assessed subgroups, median PFS was longer with lenvatinib-plus-pembrolizumab than with sunitinib treatment, notably among patients with baseline bone metastases (HR 0.33, 95% CI 0.21–0.52) and patients with sarcomatoid features (HR 0.39, 95% CI 0.18–0.84). Median OS favored lenvatinib plus pembrolizumab over sunitinib irrespective of metastatic lesions at baseline, prior nephrectomy, and sarcomatoid features. Of interest, among patients with baseline bone metastases the HR for survival was 0.50 (95% CI 0.30–0.83) and among patients with sarcomatoid features the HR for survival was 0.91 (95% CI 0.32–2.58); though for many groups, median OS was not reached. ORR also favored lenvatinib plus pembrolizumab over sunitinib across all subgroups; similarly, complete responses also followed this pattern. Conclusion: Efficacy outcomes improved following treatment with lenvatinib-plus-pembrolizumab versus sunitinib in patients with RCC—irrespective of the presence or absence of baseline lung metastases, baseline bone metastases, baseline liver metastases, prior nephrectomy, or sarcomatoid features. These findings corroborate those of the primary CLEAR study analysis in the overall population and support lenvatinib plus pembrolizumab as a standard of care in 1L treatment for patients with advanced RCC. [ABSTRACT FROM AUTHOR]

Published
2024
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85. Systemic Immune-Inflammation Index in patients treated with first-line immune combinations for metastatic Renal Cell Carcinoma: insights from the ARON-1 study

Author

Monteiro, Fernando Sabino Marques, primary, Ondřej, Fiala, additional, Massari, Francesco, additional, Myint, Zin W., additional, Kopecky, Jindrich, additional, Kucharz, Jakub, additional, Büttner, Thomas, additional, Grande, Enrique, additional, Bourlon, Maria Teresa, additional, Molina-Cerrillo, Javier, additional, Pichler, Renate, additional, Buchler, Tomas, additional, Seront, Emmanuel, additional, Ansari, Jawaher, additional, Bamias, Aristotelis, additional, Bhuva, Dipen, additional, Vau, Nuno, additional, Porta, Camillo, additional, Fay, Andre Poisl, additional, and Santoni, Matteo, additional

Published
2023
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86. Contributors

Author

Abudayyeh, Ala, primary, Angelo, Joseph R., additional, Bassil, Claude, additional, Batuman, Vecihi, additional, J., John, additional, S., Andrew, additional, T., Brendan, additional, C., Juan, additional, Chang, Anthony, additional, Chen, Sheldon, additional, P., Eric, additional, Cosmai, Laura, additional, Desai, Vidhi, additional, E., Marcia, additional, Gupta, Mohit, additional, W., Kevin, additional, Gallieni, Maurizio, additional, Gautam-Goyal, Pranisha, additional, Glezerman, Ilya, additional, S., Vijay, additional, Gutgarts, Victoria, additional, Heemann, Uwe, additional, Herlitz, Leal, additional, Hingorani, Sangeeta, additional, J., Jonathan, additional, L., Jean, additional, L., Susie, additional, A., Colin, additional, Jaffer, Insara, additional, D., Kenar, additional, Joseph, Catherine, additional, Kala, Jaya, additional, Karam, Sabine, additional, Kemmner, Stefan, additional, F., Sana, additional, Kitchlu, Abhijat, additional, Lahoti, Amit, additional, L., Benjamin, additional, Latcha, Sheron, additional, L., Wai, additional, L., Randy, additional, Madan, Niti, additional, Malhotra, Prashant, additional, Mollee, Peter, additional, A., Mark, additional, M., Phillip, additional, Delanaye, Pierre, additional, Porta, Camillo, additional, Radhakrishnan, Jai, additional, Rastegar, Mandana, additional, F., Robert, additional, L., Danielle, additional, A., Joshua, additional, Shankaranarayanan, Divya, additional, Sawinski, Deirdre, additional, Selamet, Umut, additional, C., Anushree, additional, Sinnakirouchenan, Ramapriya, additional, Sprangers, Ben, additional, Thakkar, Jyotsana, additional, Turner, Jeffrey, additional, Vasudev, Brahm, additional, R., Dia, additional, Wanchoo, Rimda, additional, M., Brendan, additional, H., Robert, additional, Wong, Germaine, additional, and Temiz, Gökhan, additional

Published
2020
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90. Is It Possible to Improve Prognostic Classification in Patients Affected by Metastatic Renal Cell Carcinoma With an Intermediate or Poor Prognosis?

Author

Iacovelli, Roberto, De Giorgi, Ugo, Galli, Luca, Zucali, Paolo, Nolè, Franco, Sabbatini, Roberto, Fraccon, Anna Paola, Basso, Umberto, Mosca, Alessandra, Atzori, Francesco, Santini, Daniele, Facchini, Gaetano, Fornarini, Giuseppe, Pasini, Felice, Masini, Cristina, Massari, Francesco, Buti, Sebastiano, Sava, Teodoro, Sacco, Cosimo, Ricotta, Riccardo, Sperduti, Isabella, Tortora, Giampaolo, and Porta, Camillo

Published
2018
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97. Geographical differences in the management of metastatic de novo renal cell carcinoma in the era of immune-combinations

Author

PORTA, Camillo, primary, BAMIAS, Aristotelis, additional, ZAKOPOULOU, Roubini, additional, MYINT, Zin W., additional, CAVASIN, Nicolò, additional, IACOVELLI, Roberto, additional, PICHLER, Martin, additional, KOPECKY, Jindrich, additional, KUCHARZ, Jakub, additional, RIZZO, Mimma, additional, GALLI, Luca, additional, BÜTTNER, Thomas, additional, DE GIORGI, Ugo, additional, KANESVARAN, Ravindran, additional, FIALA, Ondřej, additional, GRANDE, Enrique, additional, ZUCALI, Paolo A., additional, KOPP, Ray M., additional, FORNARINI, Giuseppe, additional, BOURLON, Maria T., additional, SCAGLIARINI, Sarah, additional, MOLINA-CERRILLO, Javier, additional, AURILIO, Gaetano, additional, MATRANA, Marc R., additional, PICHLER, Renate, additional, CATTRINI, Carlo, additional, BÜCHLER, Tomáš, additional, MASSARI, Francesco, additional, MOLLICA, Veronica, additional, SERONT, Emmanuel, additional, CALABRÒ, Fabio, additional, PINTO, Alvaro, additional, BERARDI, Rossana, additional, ZGURA, Anca, additional, MAMMONE, Giulia, additional, ANSARI, Jawaher, additional, ATZORI, Francesco, additional, CHIARI, Rita, additional, CAFFO, Orazio, additional, PROCOPIO, Giuseppe, additional, SUNELA, Kaisa, additional, BASSANELLI, Maria, additional, ORTEGA, Cinzia, additional, GRILLONE, Francesco, additional, LANDMESSER, Johannes, additional, MERLER, Sara, additional, MESSINA, Carlo, additional, KÜRONYA, Zsófia, additional, MOSCA, Alessandra, additional, BHUVA, Dipen, additional, SANTINI, Daniele, additional, VAU, Nuno, additional, MORELLI, Franco, additional, INCORVAIA, Lorena, additional, REBUZZI, Sara E., additional, ROVIELLO, Giandomenico, additional, SOARES, Andrey, additional, ZABALZA, Ignacio O., additional, RIZZO, Alessandro, additional, BISONNI, Renato, additional, PIERANTONI, Francesco, additional, SORGENTONI, Giulia, additional, MONTEIRO, Fernando S., additional, BATTELLI, Nicola, additional, BUTI, Sebastiano, additional, and SANTONI, Matteo, additional

Published
2023
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98. Real-world Outcome of Patients with Advanced Renal Cell Carcinoma and Intermediate- or Poor-risk International Metastatic Renal Cell Carcinoma Database Consortium Criteria Treated by Immune-oncology Combinations: Differential Effectiveness by Risk Group?

Author

Santoni, Matteo, primary, Buti, Sebastiano, additional, Myint, Zin W., additional, Maruzzo, Marco, additional, Iacovelli, Roberto, additional, Pichler, Martin, additional, Kopecky, Jindrich, additional, Kucharz, Jakub, additional, Rizzo, Mimma, additional, Galli, Luca, additional, Büttner, Thomas, additional, De Giorgi, Ugo, additional, Kanesvaran, Ravindran, additional, Fiala, Ondřej, additional, Grande, Enrique, additional, Zucali, Paolo Andrea, additional, Kopp, Ray Manneh, additional, Fornarini, Giuseppe, additional, Bourlon, Maria T., additional, Scagliarini, Sarah, additional, Molina-Cerrillo, Javier, additional, Aurilio, Gaetano, additional, Matrana, Marc R., additional, Pichler, Renate, additional, Cattrini, Carlo, additional, Büchler, Tomas, additional, Massari, Francesco, additional, Seront, Emmanuel, additional, Calabrò, Fabio, additional, Pinto, Alvaro, additional, Berardi, Rossana, additional, Zgura, Anca, additional, Mammone, Giulia, additional, Ansari, Jawaher, additional, Atzori, Francesco, additional, Chiari, Rita, additional, Bamias, Aristotelis, additional, Caffo, Orazio, additional, Procopio, Giuseppe, additional, Sunela, Kaisa, additional, Bassanelli, Maria, additional, Ortega, Cinzia, additional, Grillone, Francesco, additional, Landmesser, Johannes, additional, Milella, Michele, additional, Messina, Carlo, additional, Küronya, Zsófia, additional, Mosca, Alessandra, additional, Bhuva, Dipen, additional, Santini, Daniele, additional, Vau, Nuno, additional, Morelli, Franco, additional, Incorvaia, Lorena, additional, Rebuzzi, Sara Elena, additional, Roviello, Giandomenico, additional, Soares, Andrey, additional, Bisonni, Renato, additional, Bimbatti, Davide, additional, Zabalza, Ignacio Ortego, additional, Rizzo, Alessandro, additional, Mollica, Veronica, additional, Sorgentoni, Giulia, additional, Monteiro, Fernando Sabino M., additional, Battelli, Nicola, additional, Bracarda, Sergio, additional, and Porta, Camillo, additional

Published
2023
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