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The authors have observed 203 patients at the age of 75-87 with acute coronary insufficiency, 34 patients died on the 6th-8th days of treatment. In 22 of them death was caused by myocardial infarction, in 12--by clinically unrecognized peritonitis. A retrospective analysis of hemostasis was made on admission of the patients to the hospital and on the 5th day of treatment. In the initial state all the patients had the activated system of blood coagulation and the depressed system of anticoagulation. On the 5th day those who later died from peritonitis had had considerably decreased activity of the anticoagulating system of blood. The cause of unrecognized peritonitis in elderly and senile patients with acute coronary insufficiency is thought to be thrombogenesis in microvessels of the intestine.

Conventional treatment for BPH in recent decades has been transurethral resection of the prostate (TURP) or open prostatectomy, depending on adenoma volume. As TURP is a surgical treatment associated with high morbidity, a certain failure rate and mortality, urologists have been looking for other alternative treatments that are safer and at least as effective. Prostatic tissue ablation is one of the preferred alternative BPH treatments today and can be achieved with laser or with TURAPY--Transurethral Ablation Prostatectomy. This new treatment based on thermeablation of the prostate has been introduced recently by Direx Medical Systems. The treatment is administered with a transurethral Folley-like electrode delivering temperatures in the range of 80 degrees C. TURAPY causes extensive ablation of the tissue around the prostatic urethra, without the complications of a surgical procedure. Twenty two men, age 76 to 92 years (mean 79) with symptomatic Benign Prostatic Hyperplasia (BPH) and suprapubuc urinary fistulas were treated with the computer controlled radio frequency device TURAPY as day cases under local anaesthesia. In 1, 5-2 months after the procedure urination was restored, urinary fistulas healed.

The content of 25 mineral elements in roots and rhizomes of Sanguisorba oficinalis stored up in Kemerovskaja region were determined by the method of spectral emission and atomic-absorption spectroscopy. The data are important hygienic criteria for quality of raw materials. The content of Cu and Pb does not exceed the maximum permissible concentrations adopted in this country for these elements. The relatively high concentrations of some elements observed in separate samples reflect ecological conditions of growing place of this plant.

Spatial structures of a chymotryptic fragment C2 (residues 1-71) of bacterioopsin from Halobacterium halobium, solubilized in a mixture of methanol/chloroform (1:1, by vol.) and 0.1 M 2HCO2NH4, or in perdeuterated sodium (2H)dodecyl sulfate (SDS) micelles in the presence of perdeuterated (2,2,2-2H)trifluoroethanol, were determined by two-dimensional and three-dimensional heteronuclear 15N-1H NMR techniques. The influence of (2,2,2-2H)trifluoroethanol on the conformational dynamics of C2 in micelles and the effect of the salt (organic mixture) were studied. Under the best conditions, 1H and 15N resonances of 15N-uniformly enriched protein were assigned in both milieus by homonuclear two-dimensional NOE (NOESY) and two-dimensional total-correlated (TOCSY) spectra and heteronuclear three-dimensional NOESY-multiple-quantum-correlation (HMQC) and TOCSY-HMQC spectra. 651 (organic mixture) and 520 (micelles) interproton-distance constraints, derived from volumes of cross-peaks in two-dimensional NOESY and three-dimensional NOESY-HMQC spectra, along with deuterium exchange rates of amide groups measured in both milieus and 51 HN-C alpha H coupling constants obtained in the case of the organic mixture, were used in the construction of C2 spatial structures. Obtained structures are similar in both milieus and have two right-handed alpha-helical regions stretching from Pro8 to Met32 and Phe42 to Tyr64 (organic mixture), and from Pro8 to Met32 and Ala39 to Leu62 (micelles). In micelles, the second alpha helix is terminated by C-cap Gly63, adopting a conformation characteristic of a left-handed helix. Residues Gly65 to Thr67 from the turn of a right-handed helix. In the isotropic medium of the organic mixture, the C-terminal region of residues 65-71 lacks an ordered structure. Torsion angles chi 1 were unequivocally determined for 18 alpha-helical residues in both milieus. In the isotropic organic mixture and anisotropic micellar system, C2 remains a compact structure with a characteristic size of 3.0-3.5 nm. C2 seems to be present in at least two conformational states, packed and unpacked. Using NMR data, along with the electron cryomicroscopy model of bacteriorhodopsin [Henderson, R., Baldwin, J. M., Ceska, T. A., Zemlin, F., Beckman, E. & Downing, K. H. (1990) J. Mol. Biol. 213, 899-929], we suggested a model for the conformation of C2 in this putative close-packed state. However, no NOE contact between alpha helices was found in either milieu.

Under analysis are results of pancreatoduodenal resections in 71 patients. In patients with mechanical jaundice lymph drainage with sorption and return of lymph into the vascular bed was used during the preoperative preparation. Occlusion of the duct system of the pancreas stump with glue KL-3 was performed on 62 patients, in 9 patients choledochocholecysto-anastomosis was used in order to improve the quality of the biliodigestive opening. A cryoprocedure on the nonremoved portion of the tumor was performed in 3 cases on the posterolateral surface of the portal vein. These measures allowed the postoperative lethality to be reduced up to 11.2%.

Hemostasis has been studied over time in 137 patients with renal cancer. Of these, 69 underwent surgery only, 68 received combined treatment with preoperative large fractionation radiotherapy. It has been established that renal cancer development in the body stimulates intravascular blood coagulation (IVBC). In the patients with renal cancer who were radiation treated, IVBC activation was more noticeable than in those who had surgery only. To prevent IVBC activation and the development of the DIVC-syndrome, it is proposed to prescribe deaggregates in the period of preoperative therapy and heparin in the postoperative period.

Hemocoagulation status as well as that of non-enzymatic fibrinolysis and microcirculation were studied in 137 cases of T2--3NxMo urinary bladder cancer before and at various stages after segmental resection of the bladder. 75 patients were operated on under peridural anesthesia (group I) and 62--under endotracheal one (group 2). Postoperative blood anticoagulative function disorders were found to be less pronounced in group I.

The mechanism of hemocoagulation before, during and after combined therapy was studied in 47 cases of testicular tumor. Thrombophilia was suggested by the basal level of hemocoagulation. All patients received a course of combined therapy which included surgery, telegammatherapy and polychemotherapy. In the course of treatment, all patients revealed a decrease in the coagulative properties of blood which manifested itself in hemorrhages in 7 cases. After therapy, blood coagulation indexes did not vary much from normal. This is believed by the authors to be an indication of the efficacy of the treatment.

Retrospective evaluation of the state of hemostasis in 20 patients dying with pulmonary artery thromboembolism (PATE) after combined treatment of renal carcinoma (10) and urinary bladder carcinoma (10) was performed. The signs of intravascular blood coagulation (IVBC) in the initial condition were determined in all the patients. After a course of pre-operation actin therapy with large fractions (totally 20 g) activation of IVBC was observed both in renal and urinary bladder carcinoma. In the postoperation period, on the day of PATE development in patients with renal carcinoma the state of hemostasis corresponded to stage I of disseminated intravascular coagulation syndrome. In patients with urinary bladder carcinoma after operation the state of hemostasis corresponded to stage II of DIVC-syndrome with signs of local hemorrhage of the urinary bladder wound. The therapy of this condition with fibrinolysis inhibitors (aminocaproic acid) with hemotransfusion without heparin facilitated thrombus formation in these patients in deep pelvic veins followed by PATE.

An analysis of results of treatment of 163 children with acute diseases of the scrotum organs for five years has been made. The authors consider that urgent surgery for acute diseases parallel with establishing more precise localization of the process is a good pathogenetic treatment, prevents the appearance of disturbances of all the testicle functions, first of all the spermatogenic function, excludes an obliteration of the deferent duct, considerably shortens staying at the hospital and is not followed by complications.

Altogether 106 patients with bladder carcinoma (Stage T3NxMo) after combined treatment were followed-up for 5 yrs. Nicotinic acid and aspirin at common doses were administered to 51 patients (the 1st group) during pre- and post-operative radiation therapy. The other 55 patients (the 2nd group) did not receive these drugs. Relapses were noted in 33.3% of the patients of the 1st group and in 76.3% of the patients of the 2nd group. The 5-year survival in the 1st group was 72.5% and in the 2nd group 27.4%. The administration of nicotinic acid and aspirin to patients during pre- and postoperative gamma-beam therapy was shown to raise the body antitumor resistance.