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54. Evaluating long-term outcomes of three approaches to retroperitoneal staging in endometrial cancer

Author

Bogani, G, Di Donato, V, Papadia, A, Buda, A, Casarin, J, Multinu, F, Plotti, F, Cuccu, I, D'Auge, T, Gasparri, M, Pinelli, C, Perrone, A, Barra, F, Sorbi, F, Cromi, A, Di Martino, G, Palaia, I, Perniola, G, Ferrero, S, De Iaco, P, Perrone, C, Angioli, R, Luvero, D, Muzii, L, Ghezzi, F, Landoni, F, Mueller, M, Benedetti Panici, P, Raspagliesi, F, Bogani, Giorgio, Di Donato, Violante, Papadia, Andrea, Buda, Alessandro, Casarin, Jvan, Multinu, Francesco, Plotti, Francesco, Cuccu, Ilaria, D'Auge, Tullio Golia, Gasparri, Maria Luisa, Pinelli, Ciro, Perrone, Anna Myriam, Barra, Fabio, Sorbi, Flavia, Cromi, Antonella, Di Martino, Giampaolo, Palaia, Innocenza, Perniola, Giorgia, Ferrero, Simone, De Iaco, Pierandrea, Perrone, Chiara, Angioli, Roberto, Luvero, Daniela, Muzii, Ludovico, Ghezzi, Fabio, Landoni, Fabio, Mueller, Michael D, Benedetti Panici, Pierluigi, Raspagliesi, Francesco, Bogani, G, Di Donato, V, Papadia, A, Buda, A, Casarin, J, Multinu, F, Plotti, F, Cuccu, I, D'Auge, T, Gasparri, M, Pinelli, C, Perrone, A, Barra, F, Sorbi, F, Cromi, A, Di Martino, G, Palaia, I, Perniola, G, Ferrero, S, De Iaco, P, Perrone, C, Angioli, R, Luvero, D, Muzii, L, Ghezzi, F, Landoni, F, Mueller, M, Benedetti Panici, P, Raspagliesi, F, Bogani, Giorgio, Di Donato, Violante, Papadia, Andrea, Buda, Alessandro, Casarin, Jvan, Multinu, Francesco, Plotti, Francesco, Cuccu, Ilaria, D'Auge, Tullio Golia, Gasparri, Maria Luisa, Pinelli, Ciro, Perrone, Anna Myriam, Barra, Fabio, Sorbi, Flavia, Cromi, Antonella, Di Martino, Giampaolo, Palaia, Innocenza, Perniola, Giorgia, Ferrero, Simone, De Iaco, Pierandrea, Perrone, Chiara, Angioli, Roberto, Luvero, Daniela, Muzii, Ludovico, Ghezzi, Fabio, Landoni, Fabio, Mueller, Michael D, Benedetti Panici, Pierluigi, and Raspagliesi, Francesco

Abstract

Objective: Sentinel lymph node mapping (SNM) has gained popularity in managing apparent early-stage endometrial cancer (EC). Here, we evaluated the long-term survival of three different approaches of nodal assessment. Methods: This is a multi-institutional retrospective study evaluating long-term outcomes of EC patients having nodal assessment between 01/01/2006 and 12/31/2016. In order to reduce possible confounding factors, we applied a propensity-matched algorithm. Results: Overall, 940 patients meeting inclusion criteria were included in the study, of which 174 (18.5%), 187 (19.9%), and 579 (61.6%) underwent SNM, SNM followed by backup lymphadenectomy (LND) and LND alone, respectively. Applying a propensity score matching algorithm (1:1:2) we selected 500 patients, including 125 SNM, 125 SNM/backup LND, and 250 LND. Baseline characteristics of the study population were similar between groups. The prevalence of nodal disease was 14%, 16%, and 12% in patients having SNM, SNM/backup LND and LND, respectively. Overall, 19 (7.6%) patients were diagnosed with low volume nodal disease. The survival analysis comparing the three techniques did not show statistical differences in terms of disease-free (p = 0.750) and overall survival (p = 0.899). Similarly, the type of nodal assessment did not impact survival outcomes after stratification based on uterine risk factors. Conclusion: Our study highlighted that SNM provides similar long-term oncologic outcomes than LND.

Published
2022

55. Assessing the role of minimally invasive radical hysterectomy for early-stage cervical cancer

Author

Bogani, G, Di Donato, V, Muzii, L, Casarin, J, Ghezzi, F, Malzoni, M, Greggi, S, Landoni, F, Bazzurini, L, Zanagnolo, V, Multinu, F, Angioli, R, Plotti, F, Caruso, G, Fischetti, M, Ferrandina, G, Palaia, I, Benedetti Panici, P, Scambia, G, Raspagliesi, F, Bogani, Giorgio, Di Donato, Violante, Muzii, Ludovico, Casarin, Jvan, Ghezzi, Fabio, Malzoni, Mario, Greggi, Stefano, Landoni, Fabio, Bazzurini, Luca, Zanagnolo, Vanna, Multinu, Francesco, Angioli, Roberto, Plotti, Francesco, Caruso, Giuseppe, Fischetti, Margherita, Ferrandina, Gabriella, Palaia, Innocenza, Benedetti Panici, Pierluigi, Scambia, Giovanni, Raspagliesi, Francesco, Bogani, G, Di Donato, V, Muzii, L, Casarin, J, Ghezzi, F, Malzoni, M, Greggi, S, Landoni, F, Bazzurini, L, Zanagnolo, V, Multinu, F, Angioli, R, Plotti, F, Caruso, G, Fischetti, M, Ferrandina, G, Palaia, I, Benedetti Panici, P, Scambia, G, Raspagliesi, F, Bogani, Giorgio, Di Donato, Violante, Muzii, Ludovico, Casarin, Jvan, Ghezzi, Fabio, Malzoni, Mario, Greggi, Stefano, Landoni, Fabio, Bazzurini, Luca, Zanagnolo, Vanna, Multinu, Francesco, Angioli, Roberto, Plotti, Francesco, Caruso, Giuseppe, Fischetti, Margherita, Ferrandina, Gabriella, Palaia, Innocenza, Benedetti Panici, Pierluigi, Scambia, Giovanni, and Raspagliesi, Francesco

Abstract

Surgery is the mainstay of treatment in the management of early-stage cervical cancer. Until the publication of the Laparoscopic Approach to Cervical Cancer (LACC) trial, minimally invasive radical hysterectomy was the recommended approach to treat patients with early-stage disease. The results of the LACC trial questioned the adoption of minimally invasive surgery in cervical cancer. In comparison with the open approach, minimally invasive surgery correlated with worse disease-free and cancer-specific survival. Similarly, other retrospective studies highlighted this correlation, thus corroborating the results of the LACC trials. In the present review, we evaluated current evidence and further prospective of the adoption of minimally invasive radical hysterectomy in cervical cancer. Moreover, we sought to assess some unsolved issues regarding the role of minimally invasive surgery in early-stage cervical cancer patients.

Published
2022

56. Assessing the role of minimally invasive radical hysterectomy for early-stage cervical cancer

Author

Bogani, Giorgio, Di Donato, Violante, Muzii, Ludovico, Casarin, Jvan, Ghezzi, Fabio, Malzoni, Mario, Greggi, Stefano, Landoni, Fabio, Bazzurini, Luca, Zanagnolo, Vanna, Multinu, Francesco, Angioli, Roberto, Plotti, Francesco, Caruso, Giuseppe, Fischetti, Margherita, Ferrandina, Maria Gabriella, Palaia, Innocenza, Benedetti Panici, Pierluigi, Scambia, Giovanni, Raspagliesi, Francesco, Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Bogani, Giorgio, Di Donato, Violante, Muzii, Ludovico, Casarin, Jvan, Ghezzi, Fabio, Malzoni, Mario, Greggi, Stefano, Landoni, Fabio, Bazzurini, Luca, Zanagnolo, Vanna, Multinu, Francesco, Angioli, Roberto, Plotti, Francesco, Caruso, Giuseppe, Fischetti, Margherita, Ferrandina, Maria Gabriella, Palaia, Innocenza, Benedetti Panici, Pierluigi, Scambia, Giovanni, Raspagliesi, Francesco, Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), and Scambia, Giovanni (ORCID:0000-0003-2758-1063)

Abstract

Surgery is the mainstay of treatment in the management of early-stage cervical cancer. Until the publication of the Laparoscopic Approach to Cervical Cancer (LACC) trial, minimally invasive radical hysterectomy was the recommended approach to treat patients with early-stage disease. The results of the LACC trial questioned the adoption of minimally invasive surgery in cervical cancer. In comparison with the open approach, minimally invasive surgery correlated with worse disease-free and cancer-specific survival. Similarly, other retrospective studies highlighted this correlation, thus corroborating the results of the LACC trials. In the present review, we evaluated current evidence and further prospective of the adoption of minimally invasive radical hysterectomy in cervical cancer. Moreover, we sought to assess some unsolved issues regarding the role of minimally invasive surgery in early-stage cervical cancer patients.

Published
2022

57. Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Author

Bogani, Giorgio, Lalli, Luca, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Palaia, Innocenza, Perniola, Giorgia, Fischetti, Margherita, Santangelo, Giusi, Fracassi, Alice, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Cianci, Stefano, Bosio, Sara, Ruisi, Simona, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa Pasqualina, Zannoni, Gian Franco, Ferrandina, Maria Gabriella, Petrillo, Marco, Capobianco, Giampiero, Dessiole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Muschiato, Barbara, Palomba, Stefano, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Angioli, Roberto, Benedetti Panici, Pierluigi, Muzii, Ludovico, Scambia, Giovanni, Raspagliesi, Francesco, Di Donato, Violante, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Bogani, Giorgio, Lalli, Luca, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Palaia, Innocenza, Perniola, Giorgia, Fischetti, Margherita, Santangelo, Giusi, Fracassi, Alice, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Cianci, Stefano, Bosio, Sara, Ruisi, Simona, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa Pasqualina, Zannoni, Gian Franco, Ferrandina, Maria Gabriella, Petrillo, Marco, Capobianco, Giampiero, Dessiole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Muschiato, Barbara, Palomba, Stefano, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Angioli, Roberto, Benedetti Panici, Pierluigi, Muzii, Ludovico, Scambia, Giovanni, Raspagliesi, Francesco, Di Donato, Violante, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), and Scambia, Giovanni (ORCID:0000-0003-2758-1063)

Abstract

Background: Cervical dysplasia persistence/recurrence has a great impact on women's health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. Methods: This is a retrospective multi-institutional study based on charts of consecutive patients undergoing conization between 1 January 2010 and 31 December 2014. A nomogram assessing the importance of different variables was built. A cohort of patients treated between 1 January 2015 and 30 June 2016 was used to validate the nomogram. Results: A total of 2966 patients undergoing primary conization were analyzed. The median (range) patient age was 40 (18-89) years. At 5-year of follow-up, 6% of patients (175/2966) had developed a persistent/recurrent cervical dysplasia. Median (range) recurrence-free survival was 18 (5-52) months. Diagnosis of CIN3, presence of HR-HPV types, positive endocervical margins, HPV persistence, and the omission of HPV vaccination after conization increased significantly and independently of the risk of developing cervical dysplasia persistence/recurrence. A nomogram weighting the impact of all variables was built with a C-Index of 0.809. A dataset of 549 patients was used to validate the nomogram, with a C-index of 0.809. Conclusions: The present nomogram represents a useful tool for counseling women about their risk of persistence/recurrence after primary conization. HPV vaccination after conization is associated with a reduced risk of CIN2+.

Published
2022

58. Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Author

Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, G, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, A, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, A, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Leone Roberti Maggiore, U, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di Donato, V, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, V, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Benedetti Panici, P, Raspagliesi, F, Bogani, Giorgio, Scambia, Giovanni, Cimmino, Chiara, Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Gabriella, Landoni, Fabio, Bazzurini, Luca, Grassi, Tommaso, Vitobello, Domenico, Siesto, Gabriele, Perrone, Anna Myriam, Zanagnolo, Vanna, De Iaco, Pierandrea, Multinu, Francesco, Ghezzi, Fabio, Casarin, Jvan, Berretta, Roberto, Capozzi, Vito A, Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Montoli, Serena, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Martinello, Ruby, Sopracordevole, Francesco, Giorda, Giorgio, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Zullo, Fulvio, Bifulco, Giuseppe, Morelli, Michele, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Leone Roberti Maggiore, Umberto, Cianci, Stefano, Chiantera, Vito, Ercoli, Alfredo, Sozzi, Giulio, Martoccia, Angela, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G, Ettore, Giuseppe, Puppo, Andrea, Borghese, Martina, Martinelli, Canio, Muzii, Ludovico, Di Donato, Violante, Driul, Lorenza, Restaino, Stefano, Bergamini, Alice, Candotti, Giorgio, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassani, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thomasset, Raphael, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Dessole, Salvatore, Capobianco, Giampiero, Ciavattini, Andrea, Delli Carpini, Giovanni, Giannella, Luca, Mereu, Liliana, Tateo, Saverio, Sorbi, Flavia, Fambrini, Massimiliano, Cicogna, Stefania, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Consonni, Roberto, Cantaluppi, Simona, Lippolis, Antonio, Tinelli, Raffaele, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Palomba, Stefano, Calandra, Davide, Rosati, Maurizio, Gallo, Cinzia, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Benedetti Panici, Pierluigi, Raspagliesi, Francesco, Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, G, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, A, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, A, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Leone Roberti Maggiore, U, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di Donato, V, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, V, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Benedetti Panici, P, Raspagliesi, F, Bogani, Giorgio, Scambia, Giovanni, Cimmino, Chiara, Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Gabriella, Landoni, Fabio, Bazzurini, Luca, Grassi, Tommaso, Vitobello, Domenico, Siesto, Gabriele, Perrone, Anna Myriam, Zanagnolo, Vanna, De Iaco, Pierandrea, Multinu, Francesco, Ghezzi, Fabio, Casarin, Jvan, Berretta, Roberto, Capozzi, Vito A, Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Montoli, Serena, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Martinello, Ruby, Sopracordevole, Francesco, Giorda, Giorgio, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Zullo, Fulvio, Bifulco, Giuseppe, Morelli, Michele, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Leone Roberti Maggiore, Umberto, Cianci, Stefano, Chiantera, Vito, Ercoli, Alfredo, Sozzi, Giulio, Martoccia, Angela, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G, Ettore, Giuseppe, Puppo, Andrea, Borghese, Martina, Martinelli, Canio, Muzii, Ludovico, Di Donato, Violante, Driul, Lorenza, Restaino, Stefano, Bergamini, Alice, Candotti, Giorgio, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassani, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thomasset, Raphael, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Dessole, Salvatore, Capobianco, Giampiero, Ciavattini, Andrea, Delli Carpini, Giovanni, Giannella, Luca, Mereu, Liliana, Tateo, Saverio, Sorbi, Flavia, Fambrini, Massimiliano, Cicogna, Stefania, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Consonni, Roberto, Cantaluppi, Simona, Lippolis, Antonio, Tinelli, Raffaele, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Palomba, Stefano, Calandra, Davide, Rosati, Maurizio, Gallo, Cinzia, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Benedetti Panici, Pierluigi, and Raspagliesi, Francesco

Abstract

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

Published
2022

59. The use of sealing hemostat patch (HEMOPATCH®) in laparotomic myomectomy: a prospective case–control study.

Author

Montera, Roberto, Ficarola, Fernando, Plotti, Francesco, Terranova, Corrado, De Cicco Nardone, Carlo, Guzzo, Federica, Angioli, Roberto, and Luvero, Daniela

Subjects
MYOMECTOMY, SURGICAL blood loss, SURGICAL complications, CASE-control method, LONGITUDINAL method, SURGICAL robots
Abstract

Purpose: Uterine myomas are the most common gynecological disease. In these cases, a myomectomy is performed traditionally laparotomically. However, alternatives have been widely used, including laparoscopic, endoscopic, and robotic surgery. During these techniques, diffuse parenchymatous bleeding remains one of the main intraoperative and postoperative complications and sometimes requires unplanned hysterectomies. Recently, hemostatic agents and sealants have been used to prevent excessive blood loss during surgical repair. Methods: We propose a prospective case–control study on the use of a sealing hemostat patch (HEMOPATCH®) on uterine sutures in laparotomic myomectomy. In the period between July 2016 and April 2017, 46 patients with symptomatic uterine fibromatosis underwent surgery. They were divided into two groups of 23 patients, with different treatments in the hemostatic phase of oozing bleeding. HEMOPATCH® is applied in group A, and spray electrocoagulation is applied in group B. Results: In group A, we achieve faster hemostasis (p < 0.05), than in group B. We report a significantly lower C-reactive protein value on the second and third days after surgery for group A compared to group B. Conclusions: HEMOPATCH®, during laparotomic myomectomy, is a valid alternative solution for obtaining rapid hemostasis and consequently intraoperative and postoperative bleeding. Furthermore, we suggest that a lower inflammatory peritoneal state is probably correlated with the barrier effect of the patch on the suture. [ABSTRACT FROM AUTHOR]

Published
2023
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66. Vaginal cancer

Author

Di Donato, Violante, Bellati, Filippo, Fischetti, Margherita, Plotti, Francesco, Perniola, Giorgia, and Benedetti Panici, Pierluigi

Published
2012
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69. Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Author

Bogani, Giorgio, primary, Lalli, Luca, additional, Sopracordevole, Francesco, additional, Ciavattini, Andrea, additional, Ghelardi, Alessandro, additional, Simoncini, Tommaso, additional, Plotti, Francesco, additional, Casarin, Jvan, additional, Serati, Maurizio, additional, Pinelli, Ciro, additional, Bergamini, Alice, additional, Gardella, Barbara, additional, Dell’Acqua, Andrea, additional, Monti, Ermelinda, additional, Vercellini, Paolo, additional, Palaia, Innocenza, additional, Perniola, Giorgia, additional, Fischetti, Margherita, additional, Santangelo, Giusi, additional, Fracassi, Alice, additional, D’Ippolito, Giovanni, additional, Aguzzoli, Lorenzo, additional, Mandato, Vincenzo Dario, additional, Giannella, Luca, additional, Scaffa, Cono, additional, Falcone, Francesca, additional, Borghi, Chiara, additional, Malzoni, Mario, additional, Giannini, Andrea, additional, Salerno, Maria Giovanna, additional, Liberale, Viola, additional, Contino, Biagio, additional, Donfrancesco, Cristina, additional, Desiato, Michele, additional, Perrone, Anna Myriam, additional, Dondi, Giulia, additional, De Iaco, Pierandrea, additional, Ferrero, Simone, additional, Sarpietro, Giuseppe, additional, Matarazzo, Maria G., additional, Cianci, Antonio, additional, Cianci, Stefano, additional, Bosio, Sara, additional, Ruisi, Simona, additional, Mosca, Lavinia, additional, Tinelli, Raffaele, additional, De Vincenzo, Rosa, additional, Zannoni, Gian Franco, additional, Ferrandina, Gabriella, additional, Petrillo, Marco, additional, Capobianco, Giampiero, additional, Dessiole, Salvatore, additional, Carlea, Annunziata, additional, Zullo, Fulvio, additional, Muschiato, Barbara, additional, Palomba, Stefano, additional, Greggi, Stefano, additional, Spinillo, Arsenio, additional, Ghezzi, Fabio, additional, Colacurci, Nicola, additional, Angioli, Roberto, additional, Benedetti Panici, Pierluigi, additional, Muzii, Ludovico, additional, Scambia, Giovanni, additional, Raspagliesi, Francesco, additional, and Di Donato, Violante, additional

Published
2022
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75. Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Author

Bogani, Giorgio, primary, Scambia, Giovanni, additional, Cimmino, Chiara, additional, Fanfani, Francesco, additional, Costantini, Barbara, additional, Loverro, Matteo, additional, Ferrandina, Gabriella, additional, Landoni, Fabio, additional, Bazzurini, Luca, additional, Grassi, Tommaso, additional, Vitobello, Domenico, additional, Siesto, Gabriele, additional, Perrone, Anna Myriam, additional, Zanagnolo, Vanna, additional, De Iaco, Pierandrea, additional, Multinu, Francesco, additional, Ghezzi, Fabio, additional, Casarin, Jvan, additional, Berretta, Roberto, additional, Capozzi, Vito A, additional, Zupi, Errico, additional, Centini, Gabriele, additional, Pellegrino, Antonio, additional, Corso, Silvia, additional, Stevenazzi, Guido, additional, Montoli, Serena, additional, Boschi, Anna Chiara, additional, Comerci, Giuseppe, additional, Greco, Pantaleo, additional, Martinello, Ruby, additional, Sopracordevole, Francesco, additional, Giorda, Giorgio, additional, Simoncini, Tommaso, additional, Caretto, Marta, additional, Sartori, Enrico, additional, Ferrari, Federico, additional, Cianci, Antonio, additional, Sarpietro, Giuseppe, additional, Matarazzo, Maria Grazia, additional, Zullo, Fulvio, additional, Bifulco, Giuseppe, additional, Morelli, Michele, additional, Ferrero, Annamaria, additional, Biglia, Nicoletta, additional, Barra, Fabio, additional, Ferrero, Simone, additional, Leone Roberti Maggiore, Umberto, additional, Cianci, Stefano, additional, Chiantera, Vito, additional, Ercoli, Alfredo, additional, Sozzi, Giulio, additional, Martoccia, Angela, additional, Schettini, Sergio, additional, Orlando, Teresa, additional, Cannone, Francesco G, additional, Ettore, Giuseppe, additional, Puppo, Andrea, additional, Borghese, Martina, additional, Martinelli, Canio, additional, Muzii, Ludovico, additional, Di Donato, Violante, additional, Driul, Lorenza, additional, Restaino, Stefano, additional, Bergamini, Alice, additional, Candotti, Giorgio, additional, Bocciolone, Luca, additional, Plotti, Francesco, additional, Angioli, Roberto, additional, Mantovani, Giulia, additional, Ceccaroni, Marcello, additional, Cassani, Chiara, additional, Dominoni, Mattia, additional, Giambanco, Laura, additional, Amodeo, Silvia, additional, Leo, Livio, additional, Thomasset, Raphael, additional, Raimondo, Diego, additional, Seracchioli, Renato, additional, Malzoni, Mario, additional, Gorlero, Franco, additional, Di Luca, Martina, additional, Busato, Enrico, additional, Kilzie, Sami, additional, Dell'Acqua, Andrea, additional, Scarfone, Giovanna, additional, Vercellini, Paolo, additional, Petrillo, Marco, additional, Dessole, Salvatore, additional, Capobianco, Giampiero, additional, Ciavattini, Andrea, additional, Delli Carpini, Giovanni, additional, Giannella, Luca, additional, Mereu, Liliana, additional, Tateo, Saverio, additional, Sorbi, Flavia, additional, Fambrini, Massimiliano, additional, Cicogna, Stefania, additional, Romano, Federico, additional, Ricci, Giuseppe, additional, Trojano, Giuseppe, additional, Consonni, Roberto, additional, Cantaluppi, Simona, additional, Lippolis, Antonio, additional, Tinelli, Raffaele, additional, D'Ippolito, Giovanni, additional, Aguzzoli, Lorenzo, additional, Mandato, Vincenzo D, additional, Palomba, Stefano, additional, Calandra, Davide, additional, Rosati, Maurizio, additional, Gallo, Cinzia, additional, Surico, Daniela, additional, Remorgida, Valentino, additional, Ruscitto, Francesco, additional, Beretta, Paolo, additional, Benedetti Panici, Pierluigi, additional, and Raspagliesi, Francesco, additional

Published
2022
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79. Efficacy of termoablative fractional CO2 laser (Monnalisa Touch) in stress urinary incontinence.

Author

Montera, Roberto, Ficarola, Fernando, Angioli, Roberto, Terranova, Corrado, Nardone, Carlo De Cicco, Guzzo, Federica, Plotti, Francesco, and Luvero, Daniela

Subjects
URINARY stress incontinence, KEGEL exercises, CARBON dioxide lasers, URINATION disorders, REJUVENATION, PELVIC floor, LASER therapy
Abstract

Purpose: Usually, in stress urinary incontinence (SUI), nonsurgical therapy such as pelvic floor muscle training (PFMT) and lifestyle changes are proposed before surgical treatment. Laser therapy has recently been recommended for the treatment of SUI, helping to reconstruct the collagen that supports the vagina and the pelvic floor. The aim of the study was to evaluate the efficacy of SUI treatment with a CO2 intravaginal laser in patients waiting for anti‐incontinence surgery (TVT‐O). Methods: This is a prospective, case–control study. Fifty‐two patients have been included in our study and we divided them into two groups: atrophy and no atrophy. We also adopted a control group retrospectively identified from our database of patients undergoing PFMT. The subjective estimation of SUI symptoms before and after treatment was evaluated using the Visual Analog Scale before and after 1, 6, and 12 months of treatment. The objective evaluation with the urodynamic study with the stress test and a 3‐day voiding diary to count the number of episodes of incontinence, before and after treatment. Results: The intravaginal CO2 laser improved all the parameters considered for SUI in both groups. Its results were more relevant in the atrophy group, in comparison to the no atrophy group, even if they were both statistically significant. There were no statistically significant differences for all the parameters evaluated for SUI between laser treatment and PFMT in the control group. Conclusion: The CO2 laser is well‐tolerated, minimally invasive, safe, and showing efficacy for SUI. More studies are needed to consider it as first‐instance therapy, like PFMT, or at least, as a bridge therapy to surgery. [ABSTRACT FROM AUTHOR]

Published
2023
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80. Role of Protopine and Nuciferine in the Management of Nocturia, Urgency, and Dysuria in Pre- and Postmenopausal Women: A Prospective Pilot Study.

Author

Plotti, Francesco, Silvagni, Adele, Cundari, Gianna Barbara, Ficarola, Fernando, De Cicco Nardone, Carlo, Guzzo, Federica, Fabris, Silvia, Luvero, Daniela, Angioli, Roberto, Terranova, Corrado, and Montera, Roberto

Subjects
*OVERACTIVE bladder, *DYSURIA, *NOCTURIA, *POSTMENOPAUSE, *NEUROTRANSMITTER receptors, *LONGITUDINAL method
Abstract

Objectives: Nocturia was commonly treated with drugs burdened with high costs and numerous side effects; in fact, more than 70% of patients drop out of long-term treatment. Protopine and nuciferine are two alkaloids that have different effects on the neurotransmitter receptors involved in the regulation mechanism of the onset of urinary stimuli. The aim of the study was to evaluate the efficacy in controlling primarily nocturia and secondarily urgency and dysuria after 3 months of treatment with combination therapy of protopine and nuciferine syrup. Design: This is a prospective cohort study in which all patients were diagnosed with overactive bladder syndrome (OAB) and the presence of the following symptoms: nocturia, urgency, and dysuria. Thirty patients were administered 10 mL/die (16.6 mg of nuciferine, 0.09 mg of protopine) of syrup for 3 months. Patients were evaluated at baseline (T0) with the International Consultation on Incontinence Questionnaire (ICIQ), Visual Analogue Scale (VAS) for the evaluation of dysuria, Patient Perception of Intensity of Urgency Scale (PPIUS) and at 3 months (T1) with the Patients' Global Impression of Change (PGI-C) scale, PPIUS, VAS, and ICIQ. Participants: Women with diagnosis of OAB; the presence of nocturia, urgency, and dysuria symptoms agreeing to undergo treatment and compiling informed consent; and the absence of contraindications to the use of active ingredients were included in the study. Setting: Patients were recruited at T0 during the visit to the Uro-Gynecology clinic of the University of "Campus Bio-Medico" and visited again 3 months (T1) after the initiation of therapy. Methods: We explored survey data by descriptive statistics: in particular, continuous values (i.e., ICIQ) have been summarized by mean and standard deviation of discrete ordinal values (i.e., VAS, PPIUS, and bladder diary parameters at T0 and T1) by median, minimum, and maximum reported scores. Where we could assume normality in distribution, assessed by the Shapiro-Wilk test and the evaluation of the QQ plot, we compared the observation of T0 and T1 with the paired Student's t test; otherwise, we tested differences in distribution with the paired Mann-Whitney U test. Results: Thirty patients completed a 3-month therapy. The ICIQ and VAS questionnaires for the assessment of dysuria, both, reported an improvement in dysuria at T1 (p < 0.001). The PPIUS questionnaire reported an improvement in urinary urgency at T1 (p < 0.001). The PGI-C scale in T1 indicated an improvement in symptoms: 93% for nocturia, 70% for urinary urgency, and 63% for dysuria. Limitations: The weaknesses of this study are the small number of patients; as a pilot study, the study design was not randomized with a placebo and without blinding; and the short follow-up. Conclusions: Protopine and nuciferine can be an interesting alternative to primarily treat and reduce nocturia episodes, in addition to improving OAB-related urgency and dysuria. [ABSTRACT FROM AUTHOR]

Published
2023
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82. Analysis of ultrasonographic and hystopathologic features of placental invasiveness in Vitro Fertilization (IVF) pregnancies: a prospective study.

Author

Capriglione, Stella, Ettore, Carla, Terranova, Corrado, Plotti, Francesco, Angioli, Roberto, Ettore, Giuseppe, and Gulino, Ferdinando Antonio

Subjects
THIRD stage of labor (Obstetrics), SCIENTIFIC literature, FERTILIZATION in vitro, PLACENTA praevia, MULTIPLE pregnancy, EMBRYO implantation, PREGNANCY
Abstract

Purpose In Vitro Fertilization (IVF) techniques make up 1.5–5% of all births in developed countries. These pregnancies are characterized by implantation and functional alterations of the placenta, higher incidence of multiple pregnancies, higher incidence of hypertensive syndromes and pre and post partum hemorrhage (PPH). Methods Since January 2017 to May 2018 all single IVF pregnancies coming to San Camillo Hospital were considered prospectively for routine pregnancy checks until delivery and compared with a control group of spontaneous pregnancies. Each patient underwent to an obstetrical ultrasound of the third trimester at our clinic, with particular attention on the study of the placenta. Birth modalities, type and timing of third stage of labor, peri and post-partum complications were recorded. Results We had a higher incidence of cesarean sections in the IVF group (85% versus 25%) and peri and post-partum complications (38% versus 5%). We recorded a statistically significant difference of reduction in IVF pregnancies of VI (p = .0039) and VFI (p = .0043), while the FI index was not statistically significant in the two study groups (p = .4351). Conclusion Despite the small sample size of our study, our data follow the trend of scientific literature, with an effective increase in placental anomalies in IVF pregnancies compared to healthy controls. [ABSTRACT FROM AUTHOR]

Published
2022
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89. Prognostic Role of Human Epididymis Protein 4 (HE4) in Ovarian Cancer Treatment: Our Point of View

Author

Schiro Teresa, DE Cicco Nardone Carlo, Gatti Alessandra, Luvero Daniela, Guzzo Federica, Feole Laura, Rampello Stefania, DE Luca Cristiana, Messina Giuseppe, Rossini Gianmarco, Montera Roberto, Perrone Chiara, Plotti Francesco, Vitiello Francesca, Angioli Roberto, Masulli Clara, Terranova Corrado, and Ficarola Fernando

Subjects
medicine.anatomical_structure, business.industry, Cancer research, medicine, Epididymis, Ovarian cancer, medicine.disease, business
Published
2020

93. Adjuvant HPV Vaccination to Prevent Recurrent Cervical Dysplasia after Surgical Treatment: A Meta-Analysis

Author

Di Donato, Violante, primary, Caruso, Giuseppe, additional, Petrillo, Marco, additional, Kontopantelis, Evangelos, additional, Palaia, Innocenza, additional, Perniola, Giorgia, additional, Plotti, Francesco, additional, Angioli, Roberto, additional, Muzii, Ludovico, additional, Benedetti Panici, Pierluigi, additional, and Bogani, Giorgio, additional

Published
2021
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94. Tailoring parametrectomy for early cervical cancer (Stage IA-IIA FIGO): a review on surgical, oncologic outcome and sexual function

Author

PLOTTI, Francesco, primary, FICAROLA, Fernando, additional, MESSINA, Giuseppe, additional, TERRANOVA, Corrado, additional, MONTERA, Roberto, additional, GUZZO, Federica, additional, DE CICCO NARDONE, Carlo, additional, ROSSINI, Gianmarco, additional, SCHIRÒ, Teresa, additional, GATTI, Alessandra, additional, LUVERO, Daniela, additional, FEOLE, Laura, additional, and ANGIOLI, Roberto, additional

Published
2021
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96. Assessing the Long-Term Role of Vaccination against HPV after Loop Electrosurgical Excision Procedure (LEEP): A Propensity-Score Matched Comparison

Author

Bogani, Giorgio, Raspagliesi, Francesco, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Petrillo, Marco, Plotti, Francesco, Lopez, Salvatore, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Valenti, Gaetano, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Carunchio, Paola, Carlifante, Gabriele, Gianella, Luca, Scaffa, Cono, Falcone, Francesca, Ferla, Stefano, Borghi, Chiara, Ditto, Antonino, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Leone Roberti Maggiore, Umberto, Signorelli, Mauro, Chiappa, Valentina, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Bocio, Sara, Ruisi, Simona, Guerrisi, Rocco, Brusadelli, Claudia, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa Pasqualina, Zannoni, Gian Franco, Ferrandina, Maria Gabriella, Dessole, Salvatore, Angioli, Roberto, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Fischetti, Margherita, Carlea, Annunziata, Zullo, Fulvio, Muzii, Ludovico, Scambia, Giovanni, Benedetti Panici, Pierluigi, Di Donato, Violante, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Bogani, Giorgio, Raspagliesi, Francesco, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Petrillo, Marco, Plotti, Francesco, Lopez, Salvatore, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Valenti, Gaetano, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Carunchio, Paola, Carlifante, Gabriele, Gianella, Luca, Scaffa, Cono, Falcone, Francesca, Ferla, Stefano, Borghi, Chiara, Ditto, Antonino, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Leone Roberti Maggiore, Umberto, Signorelli, Mauro, Chiappa, Valentina, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Bocio, Sara, Ruisi, Simona, Guerrisi, Rocco, Brusadelli, Claudia, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa Pasqualina, Zannoni, Gian Franco, Ferrandina, Maria Gabriella, Dessole, Salvatore, Angioli, Roberto, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Fischetti, Margherita, Carlea, Annunziata, Zullo, Fulvio, Muzii, Ludovico, Scambia, Giovanni, Benedetti Panici, Pierluigi, Di Donato, Violante, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), and Scambia, Giovanni (ORCID:0000-0003-2758-1063)

Abstract

Background: Primary prevention through vaccination is a prophylactic approach aiming to reduce the risk of developing human papillomavirus (HPV)-related lesions. No mature and long-term data supported the adoption of vaccination in women undergoing conization. Methods: This is a retrospective multi-institutional study. Charts of consecutive patients undergoing conization between 2010 and 2014 were collected. All patients included had at least 5 years of follow-up. We compared outcomes of patients undergoing conization plus vaccination and conization alone. A propensity-score matching algorithm was applied in order to reduce allocation biases. The risk of developing recurrence was estimated using Kaplan-Meir and Cox hazard models. Results: Overall, charts of 1914 women were analyzed. The study group included 116 (6.1%) and 1798 (93.9%) women undergoing conization plus vaccination and conization alone, respectively. Five-year recurrence rate was 1.7% (n = 2) and 5.7% (n = 102) after conization plus vaccination and conization alone, respectively (p = 0.068). After the application of a propensity-score matching, we selected 100 patients undergoing conization plus vaccination and 200 patients undergoing conization alone. The crude number of recurrences was 2 (2%) and 11 (5.5%) for patients undergoing conization plus vaccination and conization alone, respectively (p = 0.231). Vaccination had no impact on persistent lesions (no negative examination between conization and new cervical dysplasia; p = 0.603), but reduced the risk of recurrent disease (patients who had at least one negative examination between conization and the diagnosis of recurrent cervical dysplasia; p = 0.031). Conclusions: Patients having vaccination experience a slightly lower risk of recurrence than women who had not, although not statistically significantly different. Further evidence is needed to assess the cost effectiveness of adopting vaccination in this setting.

Published
2020

99. Role of BRCA Mutation and HE4 in Predicting Chemotherapy Response in Ovarian Cancer: A Retrospective Pilot Study

Author

Plotti, Francesco, primary, Terranova, Corrado, additional, Guzzo, Federica, additional, De Cicco Nardone, Carlo, additional, Luvero, Daniela, additional, Bartolone, Martina, additional, Dionisi, Camilla, additional, Benvenuto, Domenico, additional, Fabris, Silvia, additional, Ciccozzi, Massimo, additional, Di Donato, Violante, additional, Panici, Pierluigi Benedetti, additional, and Angioli, Roberto, additional

Published
2021
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