51. Dosing antibiotics in neonates: review of the pharmacokinetic data.
- Author
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Rivera-Chaparro ND, Cohen-Wolkowiez M, and Greenberg RG
- Subjects
- Adult, Aminoglycosides administration & dosage, Aminoglycosides adverse effects, Aminoglycosides pharmacokinetics, Anti-Bacterial Agents adverse effects, Birth Weight drug effects, Body Size drug effects, Cephalosporins administration & dosage, Child, Clindamycin administration & dosage, Clindamycin adverse effects, Clindamycin pharmacokinetics, Glycopeptides administration & dosage, Glycopeptides adverse effects, Glycopeptides pharmacokinetics, Humans, Infant, Medication Reconciliation, Meropenem, Metronidazole administration & dosage, Metronidazole adverse effects, Metronidazole pharmacokinetics, Penicillanic Acid administration & dosage, Penicillanic Acid analogs & derivatives, Piperacillin administration & dosage, Piperacillin, Tazobactam Drug Combination, Thienamycins administration & dosage, Thienamycins adverse effects, Thienamycins pharmacokinetics, beta-Lactams administration & dosage, beta-Lactams adverse effects, beta-Lactams pharmacokinetics, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents pharmacokinetics, Infant, Newborn physiology
- Abstract
Antibiotics are often used in neonates despite the absence of relevant dosing information in drug labels. For neonatal dosing, clinicians must extrapolate data from studies for adults and older children, who have strikingly different physiologies. As a result, dosing extrapolation can lead to increased toxicity or efficacy failures in neonates. Driven by these differences and recent legislation mandating the study of drugs in children and neonates, an increasing number of pharmacokinetic studies of antibiotics are being performed in neonates. These studies have led to new dosing recommendations with particular consideration for neonate body size and maturation. Herein, we highlight the available pharmacokinetic data for commonly used systemic antibiotics in neonates.
- Published
- 2017
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