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Aim: The meta-analysis was conducted to estimate of the cardiovascular benefits of indiscriminate supplementation of omega-3 capsules. The results, expressed in terms of quality adjusted life years (QALY) intuitively understood by the general public, can be the basis for the (personal) decision on whether to take omega-3 supplements.Methods: The results of meta-analysis of eight double-blind, placebo-controlled clinical trials are expressed in terms of QALY, using the Markov model and Monte Carlo simulations.Results: Omega-3 supplementation results in a 8% decrease of the risk of cardiac death, unless the patients are treated by statins. Results indicate that omega-3 supplementation may prolong QALY by about a month. Old people gain less, whereas DM-2 patients and people with history of CV events gain more.Discussion: Our analysis yielded an algorithm for estimating benefit from omega-3 supplementation, based on the age and the individual risk of CV events of the patient. [ABSTRACT FROM AUTHOR]

This article explores the advancements in network-based management systems designed to enhance and streamline business services. It focuses on the development of an automated information system tailored to optimize the management of atelier services. This system automates service requests, monitors the quality and quantity of solutions, provides up-to-date service listings and optimizations, generates various reports, and offers department managers a valuable tool for automating routine tasks associated with performance registration and related documentation in their respective departments.

This article discusses the development of an automated information system for improving and improving the efficiency of the cinema. This is achieved by automating the process of submitting requests, monitoring the quality and quantity of solutions for such requests. The system is designed to provide access to the list of services provided, its timely updating and optimization; the formation of all types of reports; providing managers with a tool that automates most of the routine work on the registration of the results of the cinema.

In the modern world, technologies and market requirements are constantly changing, and the introduction of modern information systems is necessary for the successful functioning of companies in the field of trade and logistics. These systems automate processes, simplify management and increase efficiency. The advantages of implementing information systems are discussed in this article, as well as the problems that companies may face in this process. The inconsistency of the company’s hardware architecture and network with the requirements, as well as the lack of resources, including qualified personnel and finances, are the main problems. Incorrect choice of information system or resistance from employees can also cause problems. Taking into account all these factors and overcoming them is important for the successful implementation of information systems in the field of trade and logistics in order to get all the benefits from the new system.

OBJECTIVE: We tested whether neonates are subject to oxidative stress by comparing the susceptibility of umbilical blood lipids with copper-induced peroxidation. STUDY DESIGN: Umbilical arterial and venous blood samples were drawn from 32 pregnant women who delivered by elective cesarean section (CS) and from 32 pregnant women who delivered by spontaneous vaginal delivery (SVD) in a tertiary care center. Oxidative stress was evaluated by spectrophotometric monitoring of copper-induced peroxidation of serum samples. RESULTS: The lag preceding lipid peroxidation in umbilical arterial blood was shorter than the lag in umbilical venous blood, irrespective of mode of delivery (14.0+/-1.8 vs 50.6+/-8.25 min, P=.0004 in SVD group; 17.7+/-1.6 vs 39.2+/-7.6 min, P=.006 in CS group). CONCLUSION: Umbilical arterial lipids are more susceptible to peroxidation than umbilical venous lipids, indicating high oxidative stress in the fetal circulation irrespective of mode of delivery. [ABSTRACT FROM AUTHOR]

The problems of developing of soft skills of people involved in educational activities are examined, their composition in the field of education is revealed. Special attention is paid to the formation of reflective skills using the capabilities of artificial intelligence, in particular Chatbots. A technique has been developed for implementing the reflective management of the student’s intellectual activity in the Chatbots system. Case scenaries are proposed that immerse the user in the problem space of the educational situation. The effectiveness of using the capabilities of artificial intelligence in the formation of reflective skill is proved.

The study is dedicated to the evolution of “humanitarian interventions” concept from to appearance to nowadays appliance. The objective of the research was to find out different characters of humanitarian interventions: not only to apply force for preventing human rights violations but also to support the opposition, to arrange the global pressure and to enforce the define regimes to provide define reforms, to support revolutionary sentiments and etc. Besides the purpose of the study was to approve that technologies of the “humanitarian interventions” concept are used nowadays on the international arena. As a result of the comparison study of the Balkan crises and the conflict in Libya it is becoming clear that the USA and their NATO alliance methods have been used a lot of times. For the first time all of them was being tested during the Balkan conflicts at the turn of the XX-XXI centuries. These results were based on many facts and comparisons of the Balkan conflicts with situations in Libya at the beginning of the years 2010.

Oxidative stress is a term used to denote the imbalance between the concentrations of reactive oxygen and nitrogen species and the defense mechanisms of the body. Although it is generally accepted that such an imbalance plays a pivotal role in many pathologies, the term “oxidative stress” remains ill defined. In an attempt to evaluate the relationship between various assays of oxidative stress, we have analyzed the correlations between the results reported in those publications in which “oxidative stress” has been assayed by at least two methods. We found good correlations between the concentrations of several peroxidation products, including malondialdehyde, F2-Isoprostanes, lipid hydroperoxides, conjugated dienes, glutathione and protein carbonyls, but not with other criteria of “individual oxidative status” such as the concentration of antioxidants and products of DNA fragmentation (the “comet” assay). In light of these findings, we divide the assays used for evaluation of “oxidative stress” into the following three categories: (i) assays based on measuring the concentrations of oxidation products of lipids, proteins and DNA, as well as the concentrations of antioxidants, (ii) assays used to evaluate the oxidative and reductive capacity of biological fluids and (iii) assays used to evaluate the ex vivo susceptibility of lipids to oxidation upon their exposure to a source of free radicals. Our analyses demonstrate that oxidative stress cannot be defined in universal terms.Two results are of special interest:1.the commonly used criteria based on lipid peroxidation can not be regarded as a general estimate of the individual “oxidative status”.2.the levels of antioxidants exhibit a non-monotonic relation with other criteria for oxidative stress.Further research is required to evaluate the significance of the latter finding. [Copyright &y& Elsevier]