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53. 67 Are NICUs too busy?

Author

Beltempo, Marc, primary, Platt, Robert, additional, Julien, Anne-Sophie, additional, Blais, Regis, additional, Valerie, Bertelle, additional, Lapointe, Anie, additional, Lacroix, Guy, additional, Gravel, Sophie, additional, Cabot, Michèle, additional, and Piedboeuf, Bruno, additional

Published
2021
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54. Neurodevelopmental outcomes of preterm infants conceived by assisted reproductive technology

Author

Roychoudhury, Smita, primary, Lodha, Abhay, additional, Synnes, Anne, additional, Abou Mehrem, Ayman, additional, Canning, Roderick, additional, Banihani, Rudaina, additional, Beltempo, Marc, additional, Theriault, Katherine, additional, Yang, Junmin, additional, Shah, Prakesh S., additional, Soraisham, Amuchou S., additional, Ting, Joseph, additional, Alvaro, Ruben, additional, Adie, Mohammad, additional, Ng, Eugene, additional, Pelausa, Ermelinda, additional, Claveau, Martine, additional, Barrington, Keith, additional, Lapoint, Anie, additional, Ethier, Guillaume, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Afifi, Jehier, additional, Dahlgren, Leanne, additional, Wood, Stephen, additional, Metcalfe, Amy, additional, O’Quinn, Candace, additional, Helewa, Michael, additional, Taboun, Fatima, additional, Melamed, Nir, additional, Abenhaim, Haim, additional, Wou, Karen, additional, Gratton, Rob, additional, Boucoiran, Isabelle, additional, Taillefer, Catherine, additional, Allen, Vicky, additional, Grunau, Ruth, additional, Hendson, Leonora, additional, Moddemann, Diane, additional, de Cabo, Cecilia, additional, Nwaesei, Chukwuma, additional, Church, Paige, additional, Nguyen, Kim-Anh, additional, Khairy, May, additional, Dorval, Veronique, additional, Luu, Thuy Mai, additional, and Bélanger, Sylvie, additional

Published
2021
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55. Rates and Determinants of Mother’s Own Milk Feeding in Infants Born Very Preterm

Author

Dharel, Dinesh, primary, Singhal, Nalini, additional, Wood, Christel, additional, Cieslak, Zenon, additional, Bacchini, Fabiana, additional, Shah, Prakesh S., additional, Ye, Xiang Y., additional, Alshaikh, Belal, additional, Abenhaim, Haim, additional, Afifi, Jehier, additional, Alvaro, Ruben, additional, Andrews, James, additional, Armson, Anthony, additional, Audibert, Francois, additional, Aziz, Khalid, additional, Ballantyne, Marilyn, additional, Barrett, Jon, additional, Beltempo, Marc, additional, Berard, Anick, additional, Bertelle, Valerie, additional, Blais, Lucie, additional, Bocking, Alan, additional, Bodani, Jaya, additional, Burrows, Jason, additional, Butt, Kimberly, additional, Canning, Roderick, additional, Carson, George, additional, Chaillet, Nils, additional, Chandra, Sue, additional, Church, Paige, additional, Coughlin, Kevin, additional, Crane, Joan, additional, Creighton, Dianne, additional, Da Silva, Orlando, additional, Daboval, Thierry, additional, Dahlgren, Leanne, additional, Daspal, Sibasis, additional, de Cabo, Cecilia, additional, Deshpandey, Akhil, additional, Dow, Kimberly, additional, Drolet, Christine, additional, Dunn, Michael, additional, el Helou, Salhab, additional, El-Chaar, Darine, additional, El-Naggar, Walid, additional, Fajardo, Carlos, additional, Foster, Jonathan, additional, Gagnon, Robert, additional, Gratton, Rob, additional, Han, Victor, additional, Harrison, Adele, additional, Hasan, Shabih, additional, Helewa, Michael, additional, Hicks, Matthew, additional, Joseph, K.S., additional, Kajetanowicz, Andrzej, additional, Kalapesi, Zarin, additional, Khairy, May, additional, Lacaze-Masmonteil, Thierry, additional, Lee, Kyong-Soon, additional, Lemyre, Brigitte, additional, Lodha, Abhay, additional, Louis, Deepak, additional, Mai Luu, Thuy, additional, Ly, Linh, additional, Majnemer, Annette, additional, Makary, Hala, additional, Marc, Isabelle, additional, Masse, Edith, additional, McDonald, Sarah D., additional, McMillan, Doug, additional, Melamed, Nir, additional, Metcalfe, Amy, additional, Moddemann, Diane, additional, Monterrosa, Luis, additional, Morais, Michelle, additional, Mukerji, Amit, additional, Mundle, William, additional, Murphy, Lynn, additional, Murphy, Kellie, additional, Nuyt, Anne-Monique, additional, Nwaesei, Chuks, additional, O’Brien, Karel, additional, Offringa, Martin, additional, Ojah, Cecil, additional, Ouellet, Annie, additional, Pasquier, Jean-Charles, additional, Pechlivanoglou, Petros, additional, Pelausa, Ermelinda, additional, Piedboeuf, Bruno, additional, Portales-Casamar, Elodie, additional, Premji, Shahirose, additional, Puligandla, Pramod, additional, Pullenayegum, Eleanor, additional, Reichert, Amber, additional, Schneider, Carol, additional, Seshia, Mary, additional, Shah, Vibhuti, additional, Sherlock, Rebecca, additional, Shivananda, Sandesh, additional, Skarsgard, Erik, additional, Skoll, Amanda, additional, Smith, Graeme, additional, Synnes, Anne, additional, Thériault, Katherine, additional, Ting, Joseph, additional, Tough, Suzanne, additional, Toye, Jennifer, additional, Ubhi, Jagdeep, additional, Vincer, Michael, additional, Whittle, Wendy, additional, Whyte, Hilary, additional, Wilson, Doug, additional, Wood, Stephen, additional, Ye, Philip, additional, Yee, Wendy, additional, and Zwicker, Jill, additional

Published
2021
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56. Gestational Age-Dependent Variations in Effects of Prophylactic Indomethacin on Brain Injury and Intestinal Injury

Author

Qureshi, Mosarrat, primary, Shah, Prakesh S., additional, Abdelgadir, Dalal, additional, Ye, Xiang Y., additional, Afifi, Jehier, additional, Yuen, Ryan, additional, Crossman, Sara Calderon, additional, Taylor, Barbara, additional, Mohammad, Khorshid, additional, Piedboeuf, Bruno, additional, Aziz, Khalid, additional, Beltempo, Marc, additional, Kanungo, Jaideep, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Mehrem, Ayman Abou, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Bodani, Jaya, additional, Sankaran, Koravangattu, additional, Strueby, Lannae, additional, Seshia, Mary, additional, Louis, Deepak, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Adie, Mohammad, additional, Lee, Kyong-Soon, additional, Ng, Eugene, additional, Lemyre, Brigitte, additional, Khurshid, Faiza, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Lapoint, Anie, additional, Ethier, Guillaume, additional, Drolet, Christine, additional, Claveau, Martine, additional, Bertelle, Valerie, additional, Masse, Edith, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Emberley, Julie, additional, Kajetanowicz, Andrzej, additional, and Lee, Shoo K., additional

Published
2021
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57. Association of Co-Exposure of Antenatal Steroid and Prophylactic Indomethacin with Spontaneous Intestinal Perforation

Author

Kandraju, Hemasree, primary, Kanungo, Jaideep, additional, Lee, Kyong-Soon, additional, Daspal, Sibasis, additional, Adie, Mohammad Amin, additional, Dorling, Jon, additional, Ye, Xiang Y., additional, Lee, Shoo K., additional, Shah, Prakesh S., additional, Beltempo, Marc, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Mehrem, Ayman Abou, additional, Toye, Jennifer, additional, Aziz, Khalid, additional, Fajardo, Carlos, additional, Bodani, Jaya, additional, Strueby, Lannae, additional, Seshia, Mary, additional, Louis, Deepak, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Ng, Eugene, additional, Lemyre, Brigitte, additional, Daboval, Thierry, additional, Khurshid, Faiza, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Lapoint, Anie, additional, Ethier, Guillaume, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Claveau, Martine, additional, St-Hilaire, Marie, additional, Bertelle, Valerie, additional, Masse, Edith, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Emberley, Julie, additional, Afifi, Jehier, additional, Kajetanowicz, Andrzej, additional, Whittle, Wendy, additional, Morais, Michelle, additional, Dahlgren, Leanne, additional, El-Chaar, Darine, additional, Theriault, Katherine, additional, Ouellet, Annie, additional, Butt, Kimberly, additional, Wood, Stephen, additional, Metcalfe, Amy, additional, O'Quinn, Candace, additional, Pylypjuk, Christy, additional, Boucoiran, Isabelle, additional, Taillefer, Catherine, additional, Crane, Joan, additional, Abenhaim, Haim, additional, Smith, Graeme, additional, Wou, Karen, additional, Chandra, Sue, additional, Ubhi, Jagdeep, additional, Carson, George, additional, Helewa, Michael, additional, Grigoriu, Ariadna, additional, Gratton, Rob, additional, Andrews, James, additional, Melamed, Nir, additional, Burrows, Jason, additional, Taboun, Fatima, additional, Wesson, Lara, additional, MacLellan, Erin, additional, Boss, Hayley, additional, and Allen, Vicky, additional

Published
2021
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58. An international trial of antioxidants in the prevention of preeclampsia (INTAPP)

Author

Xu, Hairong, Perez-Cuevas, Ricardo, Xiong, Xu, Reyes, Hortensia, Roy, Chantal, Julien, Pierre, Smith, Graeme, von Dadelszen, Peter, Leduc, Line, Audibert, François, Moutquin, Jean-Marie, Piedboeuf, Bruno, Shatenstein, Bryna, Parra-Cabrera, Socorro, Choquette, Pierre, Winsor, Stephanie, Wood, Stephen, Benjamin, Alice, Walker, Mark, Helewa, Michael, Dubé, Johanne, Tawagi, Georges, Seaward, Gareth, Ohlsson, Arne, Magee, Laura A., Olatunbosun, Femi, Gratton, Robert, Shear, Roberta, Demianczuk, Nestor, Collet, Jean-Paul, Wei, Shuqin, and Fraser, William D.

Published
2010

59. Maternal DHA supplementation and neurodevelopmental outcomes at 18-22 months of breastfed preterm neonates: follow-up of a multicenter randomized clinical trial

Author

Guillot, Mireille, Pronovost, Etienne, Jehier Kamal Afifi, Mosarrat Jabin Qureshi, Ducruet, Thierry, Mohamed, Ibrahim, Daboval, Thierry, Lemyre, Brigitte, Piedboeuf, Bruno, Nuyt, Anne Monique, Fraser, William D, Mâsse, Benoît R, Lacaze-Masmonteil, Thierry, Luu, Thuy Mai, Hendson, Leonora, Yusuf, Kamran, Lavoie, Pascal M, and Marc, Isabelle

Published
2021
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61. Impact of administration of SMOF in extremely preterm infants on bronchopulmonary dysplasia-free survival at 36 weeks' postmenstrual age

Author

Aissatou Bintou Khairy, Thilor Ndiaye, Candidate, Lavoie, Pascal M, Mohamed, Ibrahim, Pronovost, Etienne, Piedboeuf, Bruno, Simonyan, David, Angoa, Georgina, Thierry, Fraser, William, Anne, Nuyt, Monique, Lemyre, Brigitte, Mosarrat Qureshi, Jehier Afifi, Yusuf, Kamran, Lacaze-Masmonteil, Thierry, Isabelle, Marc, and Affiliations

Published
2021
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63. Mode of delivery and neonatal outcomes in extremely preterm Vertex/nonVertex twins

Author

Hiersch, Liran, primary, Shah, Prakesh S., additional, Khurshid, Faiza, additional, Masse, Edith, additional, Murphy, Kellie, additional, McDonald, Sarah D., additional, Carson, George, additional, Barrett, Jon, additional, Melamed, Nir, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Abou Mehrem, Ayman, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Bodani, Jaya, additional, Sankaran, Koravangattu, additional, Daspal, Sibasis, additional, Seshia, Mary, additional, Louis, Deepak, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Adie, Mohammad, additional, Lee, Kyong-Soon, additional, Dunn, Michael, additional, Lemyre, Brigitte, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Lapoint, Anie, additional, Ethier, Guillaume, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Claveau, Martine, additional, Beltempo, Marc, additional, Bertelle, Valerie, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Emberley, Julie, additional, Afifi, Jehier, additional, Kajetanowicz, Andrzej, additional, Lee, Shoo K., additional, Abenhaim, Haim, additional, Andrews, James, additional, Armson, Anthony, additional, Audibert, Francois, additional, Aziz, Khalid, additional, Ballantyne, Marilyn, additional, Berard, Anick, additional, Blais, Lucie, additional, Bocking, Alan, additional, Burrows, Jason, additional, Butt, Kimberly, additional, Chaillet, Nils, additional, Chandra, Sue, additional, Church, Paige, additional, Coughlin, Kevin, additional, Crane, Joan, additional, Creighton, Dianne, additional, Daboval, Thierry, additional, Dahlgren, Leanne, additional, de Cabo, Cecilia, additional, Deshpandey, Akhil, additional, Dow, Kimberly, additional, el Helou, Salhab, additional, El-Chaar, Darine, additional, El-Naggar, Walid, additional, Foster, Jonathan, additional, Gagnon, Robert, additional, Gratton, Rob, additional, Han, Victor, additional, Harrison, Adele, additional, Hasan, Shabih, additional, Helewa, Michael, additional, Hicks, Matthew, additional, Joseph, K.S., additional, Lacaze-Masmonteil, Thierry, additional, Lodha, Abhay, additional, Luu, Thuy Mai, additional, Ly, Linh, additional, Majnemer, Annette, additional, Marc, Isabelle, additional, McMillan, Doug, additional, Metcalfe, Amy, additional, Moddemann, Diane, additional, Morais, Michelle, additional, Mundle, William, additional, Murphy, Lynn, additional, Nuyt, Anne-Monique, additional, Nwaesei, Chuks, additional, O’Brien, Karel, additional, Offringa, Martin, additional, Ouellet, Annie, additional, Pasquier, Jean-Charles, additional, Pechlivanoglou, Petros, additional, Portales-Casamar, Elodie, additional, Premji, Shahirose, additional, Puligandla, Pramod, additional, Pullenayegum, Eleanor, additional, Reichert, Amber, additional, Robson, Kate, additional, Schneider, Carol, additional, Shah, Vibhuti, additional, Shivananda, Sandesh, additional, Singhal, Nalini, additional, Skarsgard, Erik, additional, Skoll, Amanda, additional, Smith, Graeme, additional, Synnes, Anne, additional, Thériault, Katherine, additional, Tough, Suzanne, additional, Ubhi, Jagdeep, additional, Vincer, Michael, additional, Whittle, Wendy, additional, Whyte, Hilary, additional, Wilson, Doug, additional, Wood, Stephen, additional, Ye, Philip, additional, Yee, Wendy, additional, and Zwicker, Jill, additional

Published
2021
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64. Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective

Author

MS Neonatologie, Mohammad, Khorshid, Scott, James N, Leijser, Lara M, Zein, Hussein, Afifi, Jehier, Piedboeuf, Bruno, de Vries, Linda S, van Wezel-Meijler, Gerda, Lee, Shoo K, Shah, Prakesh S, MS Neonatologie, Mohammad, Khorshid, Scott, James N, Leijser, Lara M, Zein, Hussein, Afifi, Jehier, Piedboeuf, Bruno, de Vries, Linda S, van Wezel-Meijler, Gerda, Lee, Shoo K, and Shah, Prakesh S

Published
2021

65. Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective

Author

Mohammad, Khorshid, primary, Scott, James N., additional, Leijser, Lara M., additional, Zein, Hussein, additional, Afifi, Jehier, additional, Piedboeuf, Bruno, additional, de Vries, Linda S., additional, van Wezel-Meijler, Gerda, additional, Lee, Shoo K., additional, and Shah, Prakesh S., additional

Published
2021
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66. In vivo tracheal occlusion in fetal mice induces rapid lung development without affecting surfactant protein C expression

Author

Maltais, France, Seaborn, Tommy, Guay, Stephane, and Piedboeuf, Bruno

Subjects
Mice as laboratory animals -- Research, Cell physiology -- Research, Fetus -- Growth, Biological sciences
Abstract

Fetal tracheal occlusion (TO) reverses lung hypoplasia by inducing rapid lung growth. Although increases in lung size accompanied by increased numbers of alveoli and capillaries have been reported, effects of TO on lung development have not been formally assessed. In the present study, the objective was to verify our prediction that the main effect of TO would be to accelerate fetal lung development. We have developed and characterized a new fetal mouse mode] of TO to best realize this goal. At embryonic day 16.5, pregnant CD1 mice were operated under general anesthesia. One fetus per dam was selected to undergo surgical TO with a surgical clip or a sham operation. The fetuses were delivered 24 or 36 h postsurgery. The maturation of lung parenchyma, evaluated by counting the generations of alveolar saccules from the terminal bronchiole to the pleura, was significantly accelerated in the TO group with a complexity of the gas exchange region comparable with postnatal days 1 and 3 after 24 or 36 h of TO. Cellular proliferation and apoptosis peaks, assessed by immunohistochemistry directed against PCNA and the active form of caspase-3, were significantly increased 24 h after surgery in the TO group compared with the sham group. However, in situ hybridization showed no significant difference in the density of type II pneumocytes expressing surfactant protein C mRNA. Our results show that brief TO during late gestation in fetal mice induces accelerated lung development with minimal effects on surfactant protein C mRNA expression. proliferating cell nuclear antigen; congenital diaphragmatic hernia; mouse model; fetal therapy

Published
2003

72. Effect of Maternal Docosahexaenoic Acid Supplementation on Bronchopulmonary Dysplasia–Free Survival in Breastfed Preterm Infants

Author

Marc, Isabelle, primary, Piedboeuf, Bruno, additional, Lacaze-Masmonteil, Thierry, additional, Fraser, William, additional, Mâsse, Benoît, additional, Mohamed, Ibrahim, additional, Qureshi, Mosarrat, additional, Afifi, Jehier, additional, Lemyre, Brigitte, additional, Caouette, Georges, additional, Bartholomew, Julie, additional, Nuyt, Anne Monique, additional, Julien, Pierre, additional, Synnes, Anne, additional, Lucas, Michel, additional, Perreault, Thérèse, additional, Strueby, Lannae, additional, Cieslak, Zenon, additional, Yusuf, Kamran, additional, Pelligra, Gustavo, additional, Massé, Edith, additional, Larsen, Bodil, additional, de Cabo, Cecilia, additional, Ruth, Chelsea, additional, Khurshid, Faiza, additional, and Lavoie, Pascal M., additional

Published
2020
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73. Neonatal Intensive Care Unit-Level Patent Ductus Arteriosus Treatment Rates and Outcomes in Infants Born Extremely Preterm

Author

Isayama, Tetsuya, primary, Kusuda, Satoshi, additional, Reichman, Brian, additional, Lee, Shoo K., additional, Lehtonen, Liisa, additional, Norman, Mikael, additional, Adams, Mark, additional, Bassler, Dirk, additional, Helenius, Kjell, additional, Hakansson, Stellan, additional, Yang, Junmin, additional, Jain, Amish, additional, Shah, Prakesh S., additional, Harrison, Adele, additional, Synnes, Anne, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Yee, Wendy, additional, Aziz, Khalid, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Sankaran, Koravangattu, additional, Daspal, Sibasis, additional, Seshia, Mary, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Nwaesei, Chuks, additional, Lee, Kyong-Soon, additional, Dunn, Michael, additional, Lemyre, Brigitte, additional, Dow, Kimberly, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Claveau, Martine, additional, Beltempo, Marc, additional, Bertelle, Valerie, additional, Masse, Edith, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Deshpandey, Akhil, additional, Afifi, Jehier, additional, Kajetanowicz, Andrzej, additional, Andersson, Sture, additional, Tammela, Outi, additional, Sankilampi, Ulla, additional, Saarela, Timo, additional, Heymann, Eli, additional, Zangen, Shmuel, additional, Smolkin, Tatyana, additional, Mimouni, Francis, additional, Bader, David, additional, Rothschild, Avi, additional, Strauss, Zipora, additional, Felszer, Clari, additional, Omari, Hussam, additional, Tov-Friedman, Smadar Even, additional, Bar-Oz, Benjamin, additional, Feldman, Michael, additional, Saad, Nizar, additional, Flidel-Rimon, Orna, additional, Weisbrod, Meir, additional, Lubin, Daniel, additional, Litmanovitz, Ita, additional, Kugelman, Amir, additional, Shinwell, Eric, additional, Klinger, Gil, additional, Nijim, Yousif, additional, Bin-Nun, Alona, additional, Golan, Agneta, additional, Mandel, Dror, additional, Fleisher-Sheffer, Vered, additional, Kohelet, David, additional, Bakhrakh, Lev, additional, Hattori, Satoshi, additional, Shirai, Masaru, additional, Ishioka, Toru, additional, Mori, Toshihiko, additional, Amizuka, Takasuke, additional, Huchimukai, Toru, additional, Yoshida, Hiroshi, additional, Sasaki, Ayako, additional, Shimizu, Junichi, additional, Nakamura, Toshihiko, additional, Maruyama, Mami, additional, Matsumoto, Hiroshi, additional, Hosokawa, Shinichi, additional, Taki, Atsuko, additional, Nakagawa, Machiko, additional, Ko, Kyone, additional, Uozumi, Azusa, additional, Nakata, Setsuko, additional, Shimazaki, Akira, additional, Yoda, Tatsuya, additional, Numata, Osamu, additional, Imamura, Hiroaki, additional, Kobayashi, Azusa, additional, Tokuriki, Shuko, additional, Uchida, Yasushi, additional, Arai, Takahiro, additional, Ito, Mitsuhiro, additional, Ieda, Kuniko, additional, Ono, Toshiyuki, additional, Hayashi, Masashi, additional, Maki, Kanemasa, additional, Yamakawa, Mie- Toru, additional, Kawai, Masahiko, additional, Fujii, Noriko, additional, Shiomi, Kozue, additional, Nozaki, Koji, additional, Wada, Hiroshi, additional, Kim, Taho, additional, Tokunaga, Yasuyuki, additional, Takatera, Akihiro, additional, Oshima, Toshio, additional, Sumida, Hiroshi, additional, Michinomae, Yae, additional, Kusumoto, Yoshio, additional, Yoshimoto, Seiji, additional, Morisawa, Takeshi, additional, Ohashi, Tamaki, additional, Takahashi, Yukihiro, additional, Sugimoto, Moriharu, additional, Ono, Noriaki, additional, Miyagawa, Shinichiro, additional, Saijo, Takahiko, additional, Yamagami, Takashi, additional, Koyano, Kosuke, additional, Kobayashi, Shoko, additional, Kanda, Takeshi, additional, Sakemi, Yoshihiro, additional, Aoki, Mikio, additional, Iida, Koichi, additional, Goshi, Mitsushi, additional, Maruyama, Yuko, additional, Kofron, Jiri, additional, Brodd, Katarina Strand, additional, Odlind, Andreas, additional, Alberg, Lars, additional, Arwehed, Sofia, additional, Hafström, Ola, additional, Kasemo, Anna, additional, Nederman, Karin, additional, Åhman, Lars, additional, Ingemarsson, Fredrik, additional, Petersson, Henrik, additional, Thurn, Pernilla, additional, Albinsson, Eva, additional, Selander, Bo, additional, Abrahamsson, Thomas, additional, Heimdahl, Ingela, additional, Sveinsdottir, Kristbjorg, additional, Wejryd, Erik, additional, Hedlund, Anna, additional, Söderberg, Maria Katarina, additional, Navér, Lars, additional, Brune, Thomas, additional, Bäckström, Jens, additional, Robinson, Johan, additional, Farooqi, Aijaz, additional, Normann, Erik, additional, Fredriksson, Magnus, additional, Palm, Anders, additional, Rosenqvist, Urban, additional, Walde, Bengt, additional, Hagman, Cecilia, additional, Ohlin, Andreas, additional, Florell, Rein, additional, Löfvenberg, Agneta Smedsaas, additional, Meyer, Philipp, additional, Kusche, Rachel, additional, Schulzke, Sven, additional, Nelle, Mathias, additional, Wagner, Bendicht, additional, Riedel, Thomas, additional, Kaczala, Grégoire, additional, Pfister, Riccardo E., additional, Tolsa, Jean-François, additional, Roth, Matthias, additional, Stocker, Martin, additional, Laubscher, Bernhard, additional, Malzacher, Andreas, additional, Micallef, John P., additional, Hegi, Lukas, additional, Arlettaz, Romaine, additional, and Bernet, Vera, additional

Published
2020
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74. Neonatal Outcomes in Very Preterm Infants With Severe Congenital Heart Defects: An International Cohort Study

Author

Norman, Mikael, primary, Håkansson, Stellan, additional, Kusuda, Satoshi, additional, Vento, Maximo, additional, Lehtonen, Liisa, additional, Reichman, Brian, additional, Darlow, Brian A., additional, Adams, Mark, additional, Bassler, Dirk, additional, Isayama, Tetsuya, additional, Rusconi, Franca, additional, Lee, Shoo, additional, Lui, Kei, additional, Yang, Junmin, additional, Shah, Prakesh S., additional, Marshall, Peter, additional, Schmidt, Peter, additional, Dhawan, Anjali, additional, Craven, Paul, additional, de Waal, Koert, additional, Simmer, Karen, additional, Gill, Andy, additional, Pillow, Jane, additional, Stack, Jacqueline, additional, Birch, Pita, additional, Cooke, Lucy, additional, Casalaz, Dan, additional, Holberton, Jim, additional, Stewart, Alice, additional, Downe, Lyn, additional, Stewart, Michael, additional, Bajuk, Barbara, additional, Berry, Andrew, additional, Hunt, Rod, additional, Kilburn, Charles, additional, De Paoli, Tony, additional, Bolisetty, Srinivas, additional, Paradisis, Mary, additional, Rieger, Ingrid, additional, Koorts, Pieter, additional, Kuschel, Carl, additional, Doyle, Lex, additional, Numa, Andrew, additional, Carlisle, Hazel, additional, Badawi, Nadia, additional, Loughran‐Fowlds, Alison, additional, Koh, Guan, additional, Davis, Jonathan, additional, Luig, Melissa, additional, Andersen, Chad, additional, Chambers, Georgina, additional, Austin, Nicola, additional, Lynn, Adrienne, additional, Darlow, Brian, additional, Edmonds, Liza, additional, Mildenhall, Lindsay, additional, Buksh, Mariam, additional, Battin, Malcolm, additional, van den Boom, Jutta, additional, Bourchier, David, additional, Richardson, Vaughan, additional, Dineen, Fiona, additional, Rajadurai, Victor Samuel, additional, Lam, Simon, additional, Fung, Genevieve, additional, Harrison, Adele, additional, Synnes, Anne, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Yee, Wendy, additional, Aziz, Khalid, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Sankaran, Koravangattu, additional, Daspal, Sibasis, additional, Seshia, Mary, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Nwaesei, Chuks, additional, Lee, Kyong‐Soon, additional, Dunn, Michael, additional, Lemyre, Brigitte, additional, Dow, Kimberly, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Claveau, Martine, additional, Beltempo, Marc, additional, Bertelle, Valerie, additional, Masse, Edith, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Deshpandey, Akhil, additional, Afifi, Jehier, additional, Kajetanowicz, Andrzej, additional, Lee, Shoo K., additional, Andersson, Sture, additional, Tammela, Outi, additional, Sankilampi, Ulla, additional, Saarela, Timo, additional, Heymann, Eli, additional, Zangen, Shmuel, additional, Smolkin, Tatyana, additional, Mimouni, Francis, additional, Bader, David, additional, Rothschild, Avi, additional, Strauss, Zipora, additional, Felszer, Clari, additional, Omari, Hussam, additional, Tov‐Friedman, Smadar Even, additional, Bar‐Oz, Benjamin, additional, Feldman, Michael, additional, Saad, Nizar, additional, Flidel‐Rimon, Orna, additional, Weisbrod, Meir, additional, Lubin, Daniel, additional, Litmanovitz, Ita, additional, Kugelman, Amir, additional, Shinwell, Eric, additional, Klinger, Gil, additional, Nijim, Yousif, additional, Bin‐Nun, Alona, additional, Golan, Agneta, additional, Mandel, Dror, additional, Fleisher‐Sheffer, Vered, additional, Kohelet, David, additional, Bakhrakh, Lev, additional, Hattori, Satoshi, additional, Shirai, Masaru, additional, Ishioka, Toru, additional, Mori, Toshihiko, additional, Amizuka, Takasuke, additional, Huchimukai, Toru, additional, Yoshida, Hiroshi, additional, Sasaki, Ayako, additional, Shimizu, Junichi, additional, Nakamura, Toshihiko, additional, Maruyama, Mami, additional, Matsumoto, Hiroshi, additional, Hosokawa, Shinichi, additional, Taki, Atsuko, additional, Nakagawa, Machiko, additional, Ko, Kyone, additional, Uozumi, Azusa, additional, Nakata, Setsuko, additional, Shimazaki, Akira, additional, Yoda, Tatsuya, additional, Numata, Osamu, additional, Imamura, Hiroaki, additional, Kobayashi, Azusa, additional, Tokuriki, Shuko, additional, Uchida, Yasushi, additional, Arai, Takahiro, additional, Ito, Mitsuhiro, additional, Ieda, Kuniko, additional, Ono, Toshiyuki, additional, Hayashi, Masashi, additional, Maki, Kanemasa, additional, Yamakawa, MieToru, additional, Kawai, Masahiko, additional, Fujii, Noriko, additional, Shiomi, Kozue, additional, Nozaki, Koji, additional, Wada, Hiroshi, additional, Kim, Taho, additional, Tokunaga, Yasuyuki, additional, Takatera, Akihiro, additional, Oshima, Toshio, additional, Sumida, Hiroshi, additional, Michinomae, Yae, additional, Kusumoto, Yoshio, additional, Yoshimoto, Seiji, additional, Morisawa, Takeshi, additional, Ohashi, Tamaki, additional, Takahashi, Yukihiro, additional, Sugimoto, Moriharu, additional, Ono, Noriaki, additional, Miyagawa, Shinichiro, additional, Saijo, Takahiko, additional, Yamagami, Takashi, additional, Koyano, Kosuke, additional, Kobayashi, Shoko, additional, Kanda, Takeshi, additional, Sakemi, Yoshihiro, additional, Aoki, Mikio, additional, Iida, Koichi, additional, Goshi, Mitsushi, additional, Maruyama, Yuko, additional, Avila‐Alvarez, Alejandro, additional, Fernandez‐Trisac, José Luis, additional, Pico, Mª Luz Couce, additional, Fernández Seara, María José, additional, Gutiérrez, Andrés Martínez, additional, Vizcaíno, Carolina, additional, Salvador Iglesias, Miriam, additional, Zaplana, Honorio Sánchez, additional, Fernández Colomer, Belén, additional, García López, José Enrique, additional, Mozo, Rafael García, additional, Martínez, M. Teresa González, additional, Muro Sebastián, Mª Dolores, additional, Carbonell, Marta Balart, additional, Barnusell, Joan Badia, additional, Puiggròs, Mònica Domingo, additional, Taulí, Corporacio Parc, additional, Aloy, Josep Figueras, additional, Mussons, Francesc Botet, additional, Sanz, Israel Anquela, additional, Galiana, Gemma Ginovart, additional, De La Santa, H., additional, Coroleu, W., additional, Iriondo, Martin, additional, Castells Vilella, Laura, additional, Porta, Roser, additional, Demestre, Xavier, additional, Martínez Nadal, Silvia, additional, de Frutos Martínez, Cristina, additional, López Cuesta, María Jesús, additional, Mora, Dolores Esquivel, additional, Tardío, Joaquín Ortiz, additional, Benavente, Isabel, additional, Alonso, Almudena, additional, Aguilera Olmos, Ramón, additional, García Cabezas, Miguel A., additional, Martínez Jiménez, Mª Dolores, additional, Jaraba Caballero, Mª Pilar, additional, Ordoñez Díaz, Mª Dolores, additional, Fagundo, Alberto Trujillo, additional, Canals, Lluis Mayol, additional, Rodrigo, Fermín García‐Muñoz, additional, Martí, Lourdes Urquía, additional, Galdo, María Fernanda Moreno, additional, Suazo, José Antonio Hurtado, additional, López, Eduardo Narbona, additional, Fernández, José Uberos, additional, Cortajarena Altuna, Miguel A., additional, Muga Zuriarrain, Oihana, additional, Mora Navarro, David, additional, Domínguez, María Teresa, additional, del Prado, Mª Yolanda Ruiz, additional, Díez, Inés Esteban, additional, Palau Benavides, María Teresa, additional, Lapeña, Santiago, additional, Prada, Teresa, additional, Mir, Eduard Soler, additional, Sánchez, Araceli Corredera, additional, Vega, Enrique Criado, additional, del Prado, Náyade, additional, Fernández, Cristina, additional, Vilaplana, Lucía Cabanillas, additional, Pérez, Irene Cuadrado, additional, Gómez, Luisa López, additional, Comeche, Laura Domingo, additional, Martín, Isabel Llana, additional, González Armengod, Carmen, additional, Labián, Carmen Muñoz, additional, Santos Muñoz, Mª José, additional, Bravo, Dorotea Blanco, additional, Pérez, Vicente, additional, Fernández, Mª Dolores Elorza, additional, González, Celia Díaz, additional, Segura, Susana Ares, additional, Azorín, Manuela López, additional, MD, Ana Belén Jimenez, additional, Sánchez‐Tamayo, Tomás, additional, Moreno, Elías Tapia, additional, González, María, additional, Sánchez Martínez, José Enrique, additional, Lloreda García, José María, additional, Orayen, Concepción Goñi, additional, González, Javier Vilas, additional, Albo, María Suárez, additional, Colmenero, Eva González, additional, Gutiérrez González, Elena Pilar, additional, Vacas del Arco, Beatriz, additional, Fernández, Josefina Márquez, additional, Gordillo, Laura Acosta, additional, Asensio, Mercedes Granero, additional, Díaz, Carmen Macías, additional, Albújar, Mar, additional, Fuster Jorge, Pedro, additional, Romero, Sabina, additional, Falero, Mónica Rivero, additional, Escobar Izquierdo, Ana Belén, additional, Estañ Capell, Javier, additional, Izquierdo Macián, Mª Isabel, additional, Montejo Vicente, Mª Mar, additional, Caballero, Raquel Izquierdo, additional, Martínez, Mª Mercedes, additional, Euba, Aintzane, additional, Serna, Amaya Rodríguez, additional, de Heredia Goya, Juan María López, additional, Legorburu, Alberto Pérez, additional, Amorós, Ana Gutiérrez, additional, Isabel, Víctor Manuel Marugán, additional, González, Natalio Hernández, additional, Gracia, Segundo Rite, additional, Faci, Mª Purificación Ventura, additional, Villagrasa, Mª Pilar Samper, additional, Kofron, Jiri, additional, Strand Brodd, Katarina, additional, Odlind, Andreas, additional, Alberg, Lars, additional, Arwehed, Sofia, additional, Hafström, Ola, additional, Kasemo, Anna, additional, Nederman, Karin, additional, Åhman, Lars, additional, Ingemarsson, Fredrik, additional, Petersson, Henrik, additional, Thurn, Pernilla, additional, Albinsson, Eva, additional, Selander, Bo, additional, Abrahamsson, Thomas, additional, Heimdahl, Ingela, additional, Sveinsdottir, Kristbjorg, additional, Wejryd, Erik, additional, Hedlund, Anna, additional, Söderberg, Maria Katarina, additional, Navér, Lars, additional, Brune, Thomas, additional, Bäckström, Jens, additional, Robinson, Johan, additional, Farooqi, Aijaz, additional, Normann, Erik, additional, Fredriksson, Magnus, additional, Palm, Anders, additional, Rosenqvist, Urban, additional, Walde, Bengt, additional, Hagman, Cecilia, additional, Ohlin, Andreas, additional, Florell, Rein, additional, Smedsaas‐Löfvenberg, Agneta, additional, Meyer, Philipp, additional, Kusche, Rachel, additional, Schulzke, Sven, additional, Nelle, Mathias, additional, Wagner, Bendicht, additional, Riedel, Thomas, additional, Kaczala, Grégoire, additional, Pfister, Riccardo E., additional, Tolsa, Jean‐François, additional, Roth, Matthias, additional, Stocker, Martin, additional, Laubscher, Bernhard, additional, Malzacher, Andreas, additional, Micallef, John P., additional, Hegi, Lukas, additional, Arlettaz, Romaine, additional, Bernet, Vera, additional, Dani, Carlo, additional, Fiorini, Patrizio, additional, Ghirri, Paolo, additional, and Tomasini, Barbara, additional

Published
2020
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76. An international trial of vitamins C and E in the prevention of preeclampsia (INTAPP trial): 2

Author

Xu, Hairong, Perez-Cuevas, Ricardo, Xiong, Xu, Reyes, Hortensia, Julien, Pierre, Smith, Graeme, Choquette, Pierre, Winsor, Stephanie, Leduc, Line, Audibert, François, Moutquin, Jean Marie, Wood, Stephen, Benjamin, Alice, Walker, Mark, Helewa, Michael, Dube, Johanne, Tawagi, Georges, Seaward, Gareth, Ohlsson, Arne, Von Dadelszen, Peter, Macgee, Laura, Olatunbosun, Femi, Piedboeuf, Bruno, Gratton, Robert, Shearman, Robert, Demianczuk, Nestor, Collet, Jean-Paul, Roy, Chantal, and Fraser, William

Published
2009

79. Comparison of Three Nursing Workload Assessment Tools in the Neonatal Intensive Care Unit and Their Association with Outcomes of Very Preterm Infants.

Author

Lemieux-Bourque, Charlotte, Piedboeuf, Bruno, Gignac, Simon, Taylor-Ducharme, Sharon, Julien, Anne-Sophie, and Beltempo, Marc

Subjects
*NEONATAL intensive care, *CONFIDENCE intervals, *RESEARCH methodology evaluation, *NEONATAL intensive care units, *DISEASES, *HEALTH outcome assessment, *RETROSPECTIVE studies, *PATIENTS, *TERTIARY care, *HOSPITAL mortality, *HOSPITAL admission & discharge, *INDUSTRIAL psychology, *DESCRIPTIVE statistics, *WORKING hours, *EMERGENCY nursing, *LONGITUDINAL method, *POISSON distribution
Abstract

Objective  Nursing workload assessment tools are widely used to determine nurse staffing requirements in the neonatal intensive care unit (NICU). We aimed to compare three existing workload assessment tools and assess their association with mortality or morbidity among very preterm infants. Study Design  Single-center retrospective cohort study of infants born <33 weeks and admitted to a 52-bed tertiary NICU in 2017 to 2018. Required nurse staffing was estimated for each shift using the Winnipeg Assessment of Neonatal Nursing Needs Tool (WANNNT) used as reference tool, the Quebec Provincial NICU Nursing Ratio (QPNNR), and the Canadian NICU Resource Utilization (CNRU). Poisson regression models with robust error variance estimators were used to assess the association between nursing provision ratios (actual number of nurses/required number of nurses) during the first 7 days of admission and neonatal outcomes. Results  Median number of nurses required per shift using the WANNNT was 25.0 (interquartile range [IQR]: 23.1–26.7). Correlation between WANNNT and QPNNR was high (r  = 0.92, p  < 0.0001), but the QPNNR underestimated the number of nurses per shift by 4.8 (IQR: 4.1–5.4). Correlation between WANNNT and CNRU was moderate (r  = 0.45, p  < 0.0001). The NICU nursing provision ratios during the first 7 days of admission calculated using the WANNNT (adjusted risk ratio [aRR]: 0.96, 95% confidence interval [CI]: 0.93–0.99) and QPNNR (aRR: 0.97, 95% CI: 0.95–0.99) were associated with mortality or morbidity. Conclusion  Lower nursing provision ratio calculated using the WANNNT and CNRU during the first 7 days of admission is associated with an increased risk of mortality/morbidity in very preterm infants. Key Points NICUs use different nursing workload assessment tools. We validated three different nursing workload assessment tools used in the NICU. Nursing provision ratio is associated the risk of mortality/morbidity in preterm infants. [ABSTRACT FROM AUTHOR]

Published
2022
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80. Asphyxiated Neonates Treated with Hypothermia: Birth Place Matters.

Author

Sabsabi, Bayane, Huet, Cloe, Rampakakis, Emmanouil, Beltempo, Marc, Brown, Richard, Lodygensky, Gregory A., Piedboeuf, Bruno, and Wintermark, Pia

Subjects
EVALUATION of medical care, HOSPITALS, BRAIN, CONFIDENCE intervals, MULTIVARIATE analysis, PATIENTS, RETROSPECTIVE studies, MAGNETIC resonance imaging, TREATMENT effectiveness, COMPARATIVE studies, HYPOTHERMIA, DESCRIPTIVE statistics, ASPHYXIA neonatorum, METROPOLITAN areas, ODDS ratio, LONGITUDINAL method
Abstract

Objective  This study aimed to assess whether the hospital level of care where asphyxiated neonates treated with hypothermia were originally born influences their outcome. Study Design  We conducted a retrospective cohort study of all asphyxiated neonates treated with hypothermia in a large metropolitan area. Birth hospitals were categorized based on provincially predefined levels of care. Primary outcome was defined as death and/or brain injury on brain magnetic resonance imaging (adverse outcome) and was compared according to the hospital level of care. Results  The overall incidence of asphyxiated neonates treated with hypothermia significantly decreased as hospital level of care increased: 1 per 1,000 live births (109/114,627) in level I units; 0.9 per 1,000 live births (73/84,890) in level II units; and 0.7 per 1,000 live births (51/71,093) in level III units (p  < 0.001). The rate of emergent cesarean sections and the initial pH within the first hour of life were significantly lower in level I and level II units compared with level III units (respectively, p  < 0.001 and p  = 0.002). In a multivariable analysis adjusting for the rates of emergent cesarean sections and initial pH within the first hour of life, being born in level I units was confirmed as an independent predictor of adverse outcome (adjusted odds ratio [OR] level I vs. level III 95% confidence interval [CI]: 2.13 [1.02–4.43], p  = 0.04) and brain injury (adjusted OR level I vs. level III 95% CI: 2.41 [1.12–5.22], p  = 0.02). Conclusion  Asphyxiated neonates born in level I units and transferred for hypothermia treatment were less often born by emergent cesarean sections, had worse pH values within the first hour of life, and had a higher incidence of adverse outcome and brain injury compared with neonates born in level III units. Further work is needed to optimize the initial management of these neonates to improve outcomes, regardless of the location of their hospital of birth. Key Points The incidence of asphyxiated neonates treated with hypothermia varied by hospital level of care. Their rates of emergent cesarean sections and their initial pH within the first hour of life varied by hospital level of care. The hospital level of care was an independent predictor of their adverse outcome, defined as death and/or brain injury on brain MRI. [ABSTRACT FROM AUTHOR]

Published
2022
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81. Erratum: Correction to: Does specialist physician supply affect pediatric asthma health outcomes? (BMC health services research (2018) 18 1 (247))

Author

Filler, Guido, Kovesi, Tom, Bourdon, Erik, Jones, Sarah Ann, Givelichian, Laurentiu, Rockman-Greenberg, Cheryl, Gilliland, Jason, Williams, Marion, Orrbine, Elaine, and Piedboeuf, Bruno

Subjects
education, human activities, Pediatrics
Abstract

In the original publication of this article [1], the institutional author's name needs to be revised from The Paediatric Chairs of Canada Mark Bernstein to The Paediatric Chairs of Canada.

Published
2019

82. Outcomes and resource usage of infants born at ≤ 25 weeks gestation in Canada

Author

Shafey, Amy, Bashir, Rani Ameena, Shah, Prakesh, Synnes, Anne, Yang, Junmin, Kelly, Edmond N., Shah, Prakesh S., Harrison, Adele, Ting, Joseph, Yee, Wendy, Aziz, Khalid, Toye, Jennifer, Fajardo, Carlos, Kalapesi, Zarin, Sankaran, Koravangattu, Daspal, Sibasis, Seshia, Mary, Alvaro, Ruben, Shivananda, Sandesh, Da Silva, Orlando, Nwaesei, Chuks, Lee, Kyong Soon, Dunn, Michael, Lemyre, Brigitte, Dow, Kimberly, Pelausa, Ermelinda, Barrington, Keith, Drolet, Christine, and Piedboeuf, Bruno

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Birth weight, Neurodevelopment, Gestational age, Retinopathy of prematurity, Retrospective cohort study, Original Articles, medicine.disease, Antenatal steroid, 03 medical and health sciences, 0302 clinical medicine, Parenteral nutrition, 030225 pediatrics, Intensive care, Periviable, Pediatrics, Perinatology and Child Health, Medicine, Gestation, 030212 general & internal medicine, Prematurity, business
Abstract

ObjectivesTo determine the outcomes and resource usage of infants born at ≤ 25 weeks gestational age (GA).MethodsRetrospective study of infants born between April 2009 and September 2011 at ≤ 25 weeks’ GA in all neonatal intensive care units in Canada with follow-up in the neonatal follow-up clinics. Short-term morbidities, neurodevelopmental impairment, significant neurodevelopmental impairment, and resource utilization of infants born at ≤ 24 weeks were compared with neonates born at 25 weeks.ResultsOf 803 neonates discharged alive, 636 (80.4%) infants born at ≤ 25 weeks’ GA were assessed at 18 to 24 months. Caesarean delivery, lower birth weight, and less antenatal steroid exposure were more common in infants born ≤ 24 weeks as compared with 25 weeks. They had significantly higher incidences of ductus arteriosus ligation, severe intracranial hemorrhage, retinopathy of prematurity as well as longer length of stay, central line days, days on respiratory support, days on total parenteral nutrition, days on antibiotics, and need for postnatal steroids. Neurodevelopmental impairment rates were 68.9, 64.5, and 55.6% (P=0.01) and significant neurodevelopmental impairment rates were 39.3, 29.6, and 20.9% (PConclusionsAdverse outcomes and resource usage were significantly higher among infants born ≤ 24 weeks GA as compared with 25 weeks GA.

Published
2019

84. Reproducibility, bioinformatic analysis and power of the SAGE method to evaluate changes in transcriptome

Author

Dinel, Stéphanie, Calvo, Ezequiel Luis, Bolduc, Carl, Belleau, Pascal, Piedboeuf, Bruno, Boivin, André, St-Amand, Jonny, Yoshioka, Mayumi, Labrie, Fernand, Snyder, Eric E., Dinel, Stéphanie, Calvo, Ezequiel Luis, Bolduc, Carl, Belleau, Pascal, Piedboeuf, Bruno, Boivin, André, St-Amand, Jonny, Yoshioka, Mayumi, Labrie, Fernand, and Snyder, Eric E.

Abstract

The serial analysis of gene expression (SAGE) method is used to study global gene expression in cells or tissues in various experimental conditions. However, its reproducibility has not yet been definitively assessed. In this study, we have evaluated the reproducibility of the SAGE method and identified the factors that affect it. The determination coefficient (R2) for the reproducibility of SAGE is 0.96. However, there are some factors that can affect the reproducibility of SAGE, such as the replication of concatemers and ditags, the number of sequenced tags and double PCR amplification of ditags. Thus, corrections for these factors must be made to ensure the reproducibility and accuracy of SAGE results. A bioinformatic analysis of SAGE data is also presented in order to eliminate these artifacts. Finally, the current study shows that increasing the number of sequenced tags improves the power of the method to detect transcripts and their regulation by experimental conditions.

Published
2020

88. Predictors of Severe Neurologic Injury on Ultrasound Scan of the Head and Risk Factor-based Screening for Infants Born Preterm

Author

Beltempo, Marc, primary, Wintermark, Pia, additional, Lemyre, Brigitte, additional, Shalish, Wissam, additional, Martel-Bucci, Andrea, additional, Narvey, Michael, additional, Ng, Eugene H., additional, Guillot, Mireille, additional, Shah, Prakesh S., additional, Kanungo, Jaideep, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Yee, Wendy, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Sankaran, Koravangattu, additional, Daspal, Sibasis, additional, Seshia, Mary, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Nwaesei, Chuks, additional, Lee, Kyong-Soon, additional, Dunn, Michael, additional, Dow, Kimberly, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Lapoint, Anie, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Claveau, Martine, additional, Bertelle, Valerie, additional, Masse, Edith, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Emberley, Julie, additional, Afifi, Jehier, additional, Kajetanowicz, Andrzej, additional, and Lee, Shoo K., additional

Published
2019
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89. Neonates with a 10-min Apgar score of zero: Outcomes by gestational age

Author

Zhong, You Jia, primary, Claveau, Martine, additional, Yoon, Eugene W., additional, Aziz, Khalid, additional, Singhal, Nalini, additional, Shah, Prakesh S., additional, Wintermark, Pia, additional, Kanungo, Jaideep, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Yee, Wendy, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Sankaran, Koravangattu, additional, Daspal, Sibasis, additional, Seshia, Mary, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Nwaesei, Chuks, additional, Lee, Kyong-Soon, additional, Dunn, Michael, additional, Lemyre, Brigitte, additional, Dow, Kimberly, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Beltempo, Marc, additional, Bertelle, Valerie, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Emberley, Julie, additional, Afifi, Jehier, additional, Kajetanowicz, Andrzej, additional, and Lee, Shoo K., additional

Published
2019
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90. Central Line-Associated Blood Stream Infections and Non–Central Line-Associated Blood Stream Infections Surveillance in Canadian Tertiary Care Neonatal Intensive Care Units

Author

Zipursky, Amy R., primary, Yoon, Eugene W., additional, Emberley, Julie, additional, Bertelle, Valerie, additional, Kanungo, Jaideep, additional, Lee, Shoo K., additional, Shah, Prakesh S., additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Yee, Wendy, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Sankaran, Koravangattu, additional, Daspal, Sibasis, additional, Seshia, Mary, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Nwaesei, Chuks, additional, Lee, Kyong-Soon, additional, Dunn, Michael, additional, Lemyre, Brigitte, additional, Dow, Kimberly, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Lapoint, Anie, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Claveau, Martine, additional, Beltempo, Marc, additional, Masse, Edith, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Afifi, Jehier, additional, and Kajetanowicz, Andrzej, additional

Published
2019
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92. Gene expression profile of androgen modulated genes in the murine fetal developing lung

Author

Côté Mélissa, Seaborn Tommy, Bresson Eva, Cormier Geneviève, Provost Pierre R, Piedboeuf Bruno, and Tremblay Yves

Subjects
Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Background Accumulating evidences suggest that sex affects lung development. Indeed, a higher incidence of respiratory distress syndrome is observed in male compared to female preterm neonates at comparable developmental stage and experimental studies demonstrated an androgen-related delay in male lung maturation. However, the precise mechanisms underlying these deleterious effects of androgens in lung maturation are only partially understood. Methods To build up a better understanding of the effect of androgens on lung development, we analyzed by microarrays the expression of genes showing a sexual difference and those modulated by androgens. Lungs of murine fetuses resulting from a timely mating window of 1 hour were studied at gestational day 17 (GD17) and GD18, corresponding to the period of surge of surfactant production. Using injections of the antiandrogen flutamide to pregnant mice, we hunted for genes in fetal lungs which are transcriptionally modulated by androgens. Results Results revealed that 1844 genes were expressed with a sexual difference at GD17 and 833 at GD18. Many genes were significantly modulated by flutamide: 1597 at GD17 and 1775 at GD18. Datasets were analyzed by using in silico tools for reconstruction of cellular pathways. Between GD17 and GD18, male lungs showed an intensive transcriptional activity of proliferative pathways along with the onset of lung differentiation. Among the genes showing a sex difference or an antiandrogen modulation of their expression, we specifically identified androgen receptor interacting genes, surfactant related genes in particularly those involved in the pathway leading to phospholipid synthesis, and several genes of lung development regulator pathways. Among these latter, some genes related to Shh, FGF, TGF-beta, BMP, and Wnt signaling are modulated by sex and/or antiandrogen treatment. Conclusion Our results show clearly that there is a real delay in lung maturation between male and female in this period, the latter pursuing already lung maturation while the proper is not yet fully engaged in the differentiation processes at GD17. In addition, this study provides a list of genes which are under the control of androgens within the lung at the moment of surge of surfactant production in murine fetal lung.

Published
2010
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97. Pregnancy-induced hypertension and infant growth at 28 and 42 days postpartum

Author

Piedboeuf Bruno, Fraser William D, Baulon Emmanuelle, Buekens Pierre, and Xiong Xu

Subjects
Gynecology and obstetrics, RG1-991
Abstract

Abstract Background No previous studies have examined the effect of pregnancy-induced hypertension (PIH) on early infant growth. The objective was to study infant growth patterns of babies born to mothers with PIH at 28 and 42 days postpartum. Methods: Design We conducted a population-based retrospective cohort study of 16,936 pregnancies delivered between January 1, 1989 through December 31, 1990 in Suzhou, China. PIH was classified as gestational hypertension, preeclampsia and severe preeclampsia. Infant Growth Percentage (IGP) was calculated as the weight gain from birth to infant weight at 28 or 42 days postpartum divided by the birth weight. Univariate analysis and multivariate linear regression were performed to compare the infant weight as well as IGP at 28 and 42 days postpartum between various types of PIH and the normotensive group. Results Infant weights at 28 and 42 days postpartum were significantly lower in severe preeclampsia (e.g., 4679.9 g at 42 days) and preeclampsia (e.g., 4763.8 g at 42 days) groups than in the normotensive group (e.g., 4869.1 g at 42 days, p < 0.01). However, there were no differences in IGP between groups. After stratifying by intrauterine growth restriction (IUGR) status, if babies were not intrauterine growth restricted, none of the PIH types showed a significantly lower weight at 28 and 42 days postpartum and their IGPs were similar to those of the reference group. When babies were growth restricted, all PIH groups showed significantly lower weights but higher IGP at 28 and 42 days postpartum as compared to the normotensive group. Conclusion Infants born to mothers with PIH but without IUGR have normal early infant growth. IUGR secondary to PIH is associated with significant catch-up growth at 28 and 42 days postpartum.

Published
2005
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98. Total parental nutrition in the newborn infant: energy substrates and respiratory gas exchange

Author

Piedboeuf, Bruno, Chessex, Philippe, Hazan, Joelle, Pineault, Marjolain, and Lavoie, Jean-Claude

Subjects
Glucose -- Health aspects, Fat -- Health aspects, Parenteral feeding -- Health aspects, Food -- Health aspects, Health
Abstract

The effects of different energy sources (such as high-glucose or high-fat diet) on lung function in adults are variable; an increased fat intake alters diffusion capacity (gas exchange), whereas an increased glucose intake elevates carbon dioxide production. In either case, the body is able to control these variations by metabolic adaptation, that is, changes in breathing and digestion patterns may keep the body functioning smoothly. The effect of a high-lipid or high-glucose diet on respiratory gas exchange of newborn infants under resting conditions has not been established previously. Ten newborn infants (ages 5 to 21 days) were selected on the basis of (1) the ability to breathe on their own, (2) weight and gestational age match, and (3) surgical placement of a feeding tube for delivering parenteral nutrition. The experiment was set up so that each infant could serve as its own control subject, with two five-day feeding periods during which the same nitrogen and energy content was delivered within a different energy source; one energy source was low in fat and high in glucose (LF) and, conversely, the other was high in fat and low in glucose (HF). Blood samples were collected and measurements, using a gas monitor to determine oxygen consumption (VO2) and carbon dioxide production (VCO2), were taken on the last day of the feeding period as the first four days let the infant adjust to the different nutrition. There was no difference in oxygen consumption values computed from either energy source, but carbon dioxide production increased during LF feeding. However, another measurement, the transcutaneous partial pressure of carbon dioxide (tcPCO2), was not affected during LF, which means the body adjusted adequately for the increase in carbon dioxide. During HF, the tcPCO2 was lower, suggesting that the body did not compensate for the changes brought on by the high-fat diet. The plasma levels of prostaglandins and thromboxanes, substances that affect blood flow by controlling the dilation of blood vessels, were also unchanged after each feeding. Although both LF and HF diets produced unwanted metabolic effects in newborn infants, HF effects on respiratory gas exchange are not as easily compensated for as LF effects. The advantages of using fat, and not glucose, as the primary dietary energy source are not clear. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

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