Search

Your search keyword '"Pfeiffer F"' showing total 1,912 results
Start Over Author "Pfeiffer F"
1,912 results on '"Pfeiffer F"'

55. Mechanisms and Dynamic Systems

Author

Koski, J., Osyczka, A., Zajac, J., Pfeiffer, F., Müller-Slany, H. H., van Campen, D. H., Nagtegaal, R., Schoofs, A. J. G., Eschenauer, Hans, editor, Koski, Juhani, editor, and Osyczka, Andrzej, editor

Published
1990
Full Text
View/download PDF

63. MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

Author

Munkhbaatar, E, Dietzen, M, Agrawal, D, Anton, M, Jesinghaus, M, Boxberg, M, Pfarr, N, Bidola, P, Uhrig, S, Hoeckendorf, U, Meinhardt, A-L, Wahida, A, Heid, I, Braren, R, Mishra, R, Warth, A, Muley, T, Poh, PSP, Wang, X, Froehling, S, Steiger, K, Slotta-Huspenina, J, van Griensven, M, Pfeiffer, F, Lange, S, Rad, R, Spella, M, Stathopoulos, GT, Ruland, J, Bassermann, F, Weichert, W, Strasser, A, Branca, C, Heikenwalder, M, Swanton, C, McGranahan, N, Jost, PJ, Munkhbaatar, E, Dietzen, M, Agrawal, D, Anton, M, Jesinghaus, M, Boxberg, M, Pfarr, N, Bidola, P, Uhrig, S, Hoeckendorf, U, Meinhardt, A-L, Wahida, A, Heid, I, Braren, R, Mishra, R, Warth, A, Muley, T, Poh, PSP, Wang, X, Froehling, S, Steiger, K, Slotta-Huspenina, J, van Griensven, M, Pfeiffer, F, Lange, S, Rad, R, Spella, M, Stathopoulos, GT, Ruland, J, Bassermann, F, Weichert, W, Strasser, A, Branca, C, Heikenwalder, M, Swanton, C, McGranahan, N, and Jost, PJ

Abstract

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning cancer cell survival despite the oncogenic stress could provide a molecular basis for potential therapeutic interventions. Here we explore the role of pro-survival genes in cancer cell integrity during clonal evolution in non-small cell lung cancer (NSCLC). We identify gains of MCL-1 at high frequency in multiple independent NSCLC cohorts, occurring both clonally and subclonally. Clonal loss of functional TP53 is significantly associated with subclonal gains of MCL-1. In mice, tumour progression is delayed upon pharmacologic or genetic inhibition of MCL-1. These findings reveal that MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.

Published
2020

98. Complementarity problems of stick-slip vibrations

Author

Pfeiffer, F.

Subjects
Vibration research -- Analysis, Friction -- Research, Machinery, Kinematics of -- Research, Science and technology
Abstract

Multibody systems with many friction contacts not being decoupled by some force laws afford a special treatment with respect to the uniqueness of the solution after a contact event. This problem can be solved by an optimization technique including unequality constraints which corresponds exactly to the physical properties of stick-slip vibrations. The theoretical background to this complementarity problem is presented and illustrated by examples from machine dynamics.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results