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The history of intellectuals consists of a long-spanning entangled web of influences, interdependencies, and inspirations. In this paper, we construe the history of intellectuals by means of a formalized network approach, and structurally analyze how communities form and develop based on their intellectual influences. We are working with a unique data set of Linked Open Data, which we critically reflect upon. In this paper we tackle the question of whether community detection can help us to identify schools of thought, as well as patterns in the influence relations of scholars. We provide a detailed description of the process of extracting Linked Open Data, the construction of longitudinal networks, and the methodology of identifying and evaluating intellectual communities in the dataset using a community detection algorithm. Finally, we track the dynamic evolution of these communities over time, and characterize the structural patterns of their evolution, and the mechanisms of their development. We contextualize the changes in selected network structures in order to establish the merit of this method for a new perspective on the history of intellectuals, their influences, and their ideas.

The tumor immune microenvironment is an important prognostic determinant in colorectal cancer (CRC). Here the authors show that tumor infiltrating neutrophils expressing high levels of CD15 interact with CD8+ T effector memory skewing them to produce GZMK, associated with tumor progression in CRC patients.

Structural and spatial aspects of cell degradation are studied using a combination of diffraction-and imaging-based tools applying laboratory X-rays, neutron scattering and synchrotron radiation with electrochemical and thermal characterization. Experimental characterization is carried out on cylindrical cells of 21700-type, where four regimes of cell degradation are identified, which are supplemented by an increased cell resistance and surface temperature during cell operation. The amount of intercalated lithium in the fully charged anodes in the fresh and aged states is determined by ex situ X-ray diffraction radiography and in situ X-ray diffraction computed tomography. The qualitatively similar character of the results revealed a loss of active lithium along with the development of a complex heterogeneous distribution over the electrode stripe.

NomadTown a resilience hub based on learning for emergency prevention, positive impact creation, and adaptation is presented. The educative background of the sub-culture found there are outlined. A thick description of the educational milieu NomadTown is situated in is given. A contextualization of this milieu is provided with a Foucauldian awareness of the dispositif (apparatus). Whether the social ecology of associations, this resilience hub is becoming embedded in, is a suitable way to make the great transition needed to deal with climate change; and how organizational learning, manifesting as network learning, is taking place are considered. Such functioning connections are embodying the networked village concept of Nahrada’s Global Village Hypothesis. I conclude that working through connected networks, in NomadTown’s educational milieu, is an effective way to make change for resilience in our human survival situation when faced with climate change. However, NomadTown needs better connections to industry and government.

Introduction: Cranial remolding orthoses (CROs) are used to treat deformational plagiocephaly. Treatment outcomes vary widely depending on treatment timing and severity of the deformity. The relative impact of these factors on success rates is not well known. Objective: This study aimed to quantify success rates of CRO treatment, based on age at initiation of treatment and the severity of cranial deformity. Study Design: This is a retrospective cohort study of infants treated for positional plagiocephaly with a CRO. Methods: A total of 300 infants with deformational plagiocephaly who were treated with a CRO were categorized into four groups by corrected age at initiation of orthotic treatment (<22 weeks, 22–25 weeks, 26–30 weeks, and >30 weeks) and into four groups by severity of their deformity (initial cranial vault asymmetry of 6–9 mm, 10–12 mm, 13–16 mm, and 17+ mm). Success rates were compared across the groups. A successful outcome was defined as achieving a final cranial vault asymmetry of 5 mm or less. Results: The overall success rate for CRO treatment was 75%. However, success rates among the groups varied from 6% to 98%, depending on the severity and the age at initiation. Severity had a more significant effect on success rates than age at initiation. The age at initiation became more influential in determining the likelihood of success when the infant's deformity was severe. Conclusions: The likelihood of achieving a successful treatment outcome with a CRO varies greatly depending on the severity of the deformity and corrected age at initiation of treatment, with severity having the greater impact. Clinical Relevance: This study provides clinicians with treatment outcomes categorized by severity and corrected age at initiation to aid in setting appropriate expectations for treatment outcomes. [ABSTRACT FROM AUTHOR]

Background Methods Results Conclusion ShuttlePump is a novel total artificial heart (TAH) recently introduced to potentially overcome the limitations associated with the current state‐of‐the‐art mechanical circulatory support devices intended for adults. In this study, we adapted the outflow cannulation of the previously established ShuttlePump TAH and evaluated the anatomical compatibility using the virtual implantation technique.We retrospectively assessed the anatomical compatibility of the ShuttlePump using virtual implantation techniques within 3D‐reconstructed anatomies of adult heart failure patients. Additionally, we examined the impact of outflow cannula modification on the hemocompatibility of the ShuttlePump through computational fluid dynamic simulations.A successful virtual implantation in 9/11 patients was achieved. However, in 2 patients, pump interaction with the thoracic cage was observed and considered unsuccessful virtual implantation. A strong correlation (r <−0.78) observed between the measured anatomical parameters and the ShuttlePump volume exceeding pericardium highlights the importance of these measurements apart from body surface area. The numerical simulation revealed that the angled outflow cannulation resulted in a maximum pressure drop of 1.8 mmHg higher than that of the straight outflow cannulation. With comparable hemolysis index, the shear stress thresholds of angled outflow differ marginally (<5%) from the established pump model. Similar washout behavior between the pump models indicate that the curvature did not introduce stagnation zone.This study demonstrates the anatomic compatibility of the ShuttlePump in patients with biventricular failure, which was achieved by optimizing the outflow cannulation without compromising hemocompatibility. Nevertheless, clinical validation is critical to ensure the clinical applicability of these findings. [ABSTRACT FROM AUTHOR]

This study on veal calf respiratory disease assessed the association between an on-farm clinical scoring system and lung ultrasonography with the postmortem inspection of the lungs. The comparisons allowed the calculation of predictive values of the diagnostic methods. In total, 600 calves on an Austrian veal calf farm were examined at the beginning and the end of the fattening period. Overall, the area under the curve (AUC) for ultrasonographic scores was 0.90 (rsp = 0.78) with a sensitivity (Se) of 0.86. The specificity (Sp) was 0.78, and the positive predictive value (PPV) was 0.74. The AUC for the physical examination was 0.76 (rsp = 0.55) with a Se of 0.64, an Sp of 0.81, and a PPV of 0.69. For the combination of ultrasonography and physical examination, an AUC curve of 0.85 (rsp = 0.69) was calculated. A Se of 0.65 and a Sp of 0.88 with a PPV of 0.73 was calculated. This study concluded that both physical and ultrasonographic examination scoring are reliable examination methods for the detection of lung diseases in veal calves.

Background: This study aims to provide guidance for the use of neoadjuvant and adjuvant systemic therapy in women with newly diagnosed stage II–IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma. Methods: EMBASE, MEDLINE, and Cochrane Library were investigated for relevant systematic reviews and phase III trials. Articles focusing on consolidation and maintenance therapies were excluded. Results: For women with potentially resectable disease, primary cytoreductive surgery, followed by six to eight cycles of intravenous three-weekly paclitaxel and carboplatin is recommended. For those with a high-risk profile for primary cytoreductive surgery, neoadjuvant chemotherapy can be an option. Adjuvant chemotherapy with six cycles of dose-dense weekly paclitaxel plus three-weekly carboplatin can be considered for women of Japanese descent. In women with stage III or IV disease, the incorporation of bevacizumab concurrent with paclitaxel and carboplatin is not recommended for use as adjuvant therapy unless bevacizumab is continued as maintenance therapy. Intravenous paclitaxel plus intraperitoneal cisplatin and paclitaxel can be considered for stage III optimally debulked women who did not receive neoadjuvant chemotherapy. However, intraperitoneal administration of chemotherapy with bevacizumab should not be considered as an option for stage II–IV optimally debulked women. Discussion: The recommendations represent a current standard of care that is feasible to implement and valued by both clinicians and patients.

Rocky Mountain spotted fever (RMSF), a tick-borne illness, can cause serious illness or death even in a healthy individual. Unfortunately, this illness can be difficult to diagnose as symptoms are nonspecific and oftentimes mimic benign viral illnesses. Delayed diagnosis can be detrimental as the timing of antibiotic administration is critical to prevent associated morbidity and mortality. A careful travel and social history can sometimes provide clues to make the diagnosis. Being aware of lesser-known objective findings such as hyponatremia, neurologic derangements, transaminitis, and thrombocytopenia may help raise suspicion for the disease. This is a case of a 72-year-old woman who presented with nonspecific symptoms and hyponatremia without known tick exposure. She was eventually diagnosed with RMSF. The timing of her presentation corresponded with a surge in COVID-19 infections throughout her area of residence, which further complicated her presentation and contributed to a delayed diagnosis.

C86H78F12I2O2P4Pt2, triclinic, P1‾ $P\overline{1}$ (no. 2), a = 11.520(1) Å, b = 12.196(1) Å, c = 15.382(2) Å, α = 73.20(1)°, β = 75.18(1)°, γ = 86.81(1)°, V = 2000.1(4) Å3, Z = 1, R gt(F) = 0.0631, wR ref(F 2) = 0.1759, T = 193(2) K.

Simple Summary: Early diagnosis of lung lesions in calves is crucial for prompt treatment intervention and management of respiratory diseases. Both a physical and a transthoracic ultrasonography scoring at time of entry offers the opportunity to re-evaluate action plans in case of illness and further facilitate implementation of prophylactic management measures e.g., intranasal vaccination. The present study highlights the advantages of an early diagnosis of respiratory diseases on various production parameters of veal calf fattening and offers the opportunity to evaluate the effect of an intranasal vaccine for bovine respiratory diseases (Bovalto® Respi Intranasal). This study evaluated the significance and predictive value of ultrasonographic and physical examination on arrival at an Austrian fattening farm. Treatment frequency and average daily weight gain (ADG) were related to physical and ultrasonographic examination results. Additionally, the effect of an intranasal vaccination in half of the examined calves was studied. The clinical and ultrasonographic health status 600 calves was recorded at the beginning and end of fattening. Half of the calves received an intranasal vaccination (Bovalto® Respi Intranasal). Overall, 44.5% showed an abnormal respiratory scoring (RS) and 56.0% showed signs of respiratory diseases in transthoracic ultrasonography (TUS) at arrival on the farm. For both RS and TUS, a categorization between ILL and HEALTHY was conducted. Results showed lower ADG in ILL calves (RS median: 0.93 kg/d; TUS median: 0.96 kg/d) compared to HEALTHY calves (RS median: 1.01 kg/d; TUS median: 1.01 kg/d). The median ADG was lower in not treated and ILL calves (RS median 0.90 kg/d; TUS: 0.93 kg/d) compared to treated and ILL calves (RS median 1.01 kg/d; TUS: 1.02 kg/d). Vaccination did not affect growth performance or occurrence of ILL, though treatment frequency was lower in VAC calves (17.0% in NVAC; 11.3% in VAC). The implementation of examination protocols for respiratory diseases may have a positive impact on production parameters (e.g., treatment frequency and ADG). [ABSTRACT FROM AUTHOR]