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We analyze the dynamics of neutrino Gaussian wave-packets, the damping of flavor oscillations and decoherence effects within the framework of extended theories of gravity. We show that, when the underlying description of the gravitational interaction admits a violation of the strong equivalence principle, the parameter quantifying such a violation modulates the wave-packet spreading, giving rise to potentially measurable effects in future neutrino experiments.

In this paper, we investigate the consequences of maximal length as well as minimal momentum scales on nonlocal correlations shared by two parties of a bipartite quantum system. To this aim, we rely on a general phenomenological scheme which is usually associated with the non-negligible spacetime curvature at cosmological scales, namely the extended uncertainty principle. In so doing, we find that quantum correlations are degraded if the deformed quantum mechanical model mimics a positive cosmological constant. This opens up the possibility to recover classicality at sufficiently large distances.

Background: Calprotectin (CP) is a calcium- and zinc-binding protein that plays a key role in innate immunity and in the recruitment of inflammatory cells. CP can be detected both in serum and in fecal samples. Serum CP (sCP) is more specific for autoimmune diseases, while fecal CP (fCP) has been well investigated for gastrointestinal diseases. Few studies have shown the clinical effectiveness of sCP as an acute-phase biomarker for gastrointestinal diseases. Aim: The aim of this narrative review is to discuss the role of sCP as a useful alternative biomarker of the acute-phase activity of gastrointestinal diseases and as a possible tool for screening and monitoring these diseases. Material and Methods: We searched original articles, abstracts, reviews, case reports, and clinical trials on PubMed®, Up-to-Date®, and Medscape® in the last ten years. Conclusion: We found that sCP could represent a useful biomarker in the evaluation of the inflammatory stage in patients with immune-mediated gastrointestinal diseases, but more studies are needed to promote its routine use in clinical practice as a diagnostic and prognostic biomarker as a replacement for fCP.

Several phenomenological approaches to quantum gravity predict the existence of a minimal measurable length and/or a maximum measurable momentum near the Planck scale. When embedded into the framework of quantum mechanics, such constraints induce a modification of the canonical commutation relations and thus a generalization of the Heisenberg uncertainty relations, commonly referred to as generalized uncertainty principle (GUP). Different models of quantum gravity imply different forms of the GUP. For instance, in the framework of string theory the GUP is quadratic in the momentum operator, while in the context of doubly special relativity it includes an additional linear dependence. Among the possible physical consequences, it was recently shown that the quadratic GUP induces a universal decoherence mechanism, provided one assumes a foamy structure of quantum spacetime close to the Planck length. Along this line, in the present work we investigate the gravitational decoherence associated to the linear-quadratic GUP and we compare it with the one associated to the quadratic GUP. We find that, despite their similarities, the two generalizations of the Heisenberg uncertainty principle yield decoherence times that are completely uncorrelated and significantly distinct. Motivated by this result, we introduce a theoretical and experimental scheme based on cavity optomechanics to measure the different time evolution of nonlocal quantum correlations corresponding to the two aforementioned decoherence mechanisms. We find that the deviation between the two predictions occurs on time scales that are macroscopic and thus potentially amenable to experimental verification. This scenario provides a possible setting to discriminate between different forms of the GUP and therefore different models of quantum gravity.

Drammaturgo ancora trascurato, Franco Scaldati rappresenta un unicum nel panorama italiano in virtù di un corpus di opere in cui la lingua palermitana risuona con incredibile forza poetica. Il saggio intende far luce sull’artista attraverso una prospettiva inedita che fa leva sullo studio degli animali e dell’animalità – zoöesis, come la definisce Una Chaudhuri – nei suoi drammi. In particolar modo, a essere approfondite sono le figure degli insetti. Cosa rappresentano questi animali? Che rapporto intercorre tra l’umano e l’animale? Qual è la linea di confine fra i due mondi? Quanto gli insetti possono essere considerati motore drammaturgico dell’opera scaldatiana? Punto di partenza e, contemporaneamente, di irraggiamento sulla produzione di Scaldati è l’analisi di Pupa Regina. Opere di fango e l’emersione di api e lucciole, insetti, questi ultimi, che ritornano anche nella scrittura del “finale mancante” de I giganti della montagna di Luigi Pirandello per l’allestimento di Federico Tiezzi (2007).

Safety training promotes safety at work, in particular through the use of engaging methods. This study introduces a newly developed measure of individual engagement in safety training, and aims to analyze the psychometric proprieties of the scale. The safety training engagement scale (STE) consists of five items pertaining to the trainee’s dedication and absorption in a safety training session. Two studies are carried out to analyze the validity of the scale. The first study focuses on the construct (internal) validity, to examine the scale’s internal consistency and dimensional structure. The second study seeks to provide further evidence for construct validity by testing the external validity of the scale. The sample consists of 913 (study 1) and 133 (study 2) participants in safety training programs in the field of the chemical industry who were invited to fill the STE scale after attending a safety training course. The results provide support to affirm the validity and reliability of the scale. The discussion describes the implication and the limitations of using the STE scale in practical safety training programs, and outlines recommendations for research to improve the scale’s robustness.

This study investigated the reciprocal relationship between self-perceived employability (SPE) and psychological well-being (PWB), a connection previously suggested by theory but not yet explored empirically in early career research. Drawing from the Conservation of Resources theory, we analysed the reciprocal effects between SPE and PWB. Using data collected from 376 Italian university students and graduates, we tested the hypotheses with the random intercept cross-lagged panel model (RI-CLPM) to analyse the SPE-PWB reciprocal linkage at both the between-person and within-person levels. While we observed a reciprocal SPE-PWB association across three waves at the between-person level, we obtained mixed findings at the within-person level. This study is the first to test the reciprocal associations between SPE and PWB among labour market entrants adopting a within-person approach. The findings offer new empirical insights into SPE during early career stages, with implications for both future research and practical applications. [ABSTRACT FROM AUTHOR]

Background: In Western countries, 10–20% of adults have gallstones, of which about 1–3% of patients are symptomatic for biliary colic. The treatment with ursodeoxycholic acid is debated. Silymarin is emerging nowadays as a natural substance with choleretic and beneficial properties, useful in the case of gallbladder sludge. Aim: The aim of our study was to evaluate the efficacy of supplementation with a mix of natural compounds (milk thistle 150 mg, artichoke 150 mg, and green tea 150 mg) in patients affected by biliary sludge in reducing biliary colic and biliary sludge and improving lipid profiles after 3 months of treatment compared to a control group. Patients and Methods: This was an interventional open study on 65 consecutive adult patients (23 M/42 F; mean age 61.0 ± 18.7 years) affected by biliary sludge without indication for surgery, admitted to the Internal Medicine Department of San Carlo di Nancy Hospital Rome. Forty patients were treated with milk thistle 150 mg, artichoke 150 mg, and green tea 150 mg, 2 capsules/day for three months, and followed up for abdominal ultrasound, the frequency of occurrence of biliary colic, and blood tests. Twenty-five control group patients were followed up for abdominal ultrasound, the frequency of occurrence of biliary colic, and blood tests after 3 months. Results: In Group A, we observed a disappearance of biliary sludge in 32.4% (12/37) of patients compared to 8.7% in the control group (p < 0.05). In 32.4% of treated patients, we report a reduction in biliary sludge. There were no side effects during treatment. In both groups, we registered a significant reduction in transaminases and gamma-glutamyl transferase (γ-GT) (p < 0.05). No significant modification of the lipid profile was observed. Conclusions: The treatment with a mix of natural compounds (milk thistle, artichoke, and green tea) in patients affected by symptomatic biliary colic resulted in efficacy and safety in reducing biliary sludge, biliary colic, and transaminases levels after three months of treatment. The limitations of this study include a small number of patients and the absence of long-term follow up after the end of treatment. [ABSTRACT FROM AUTHOR]

Urinary tract infections (UTIs) are one of the most common bacterial infections, affecting more than 150 million people each year in the world. UTIs have grown exponentially in the last few years. They represent a major load for both individuals and society. The highest incidence (about 55–60%) concerns women. Many pathogens are involved in UTIs, most of which are derived from the gut. Recent studies, together with recent diagnostic techniques (such as quantitative culture of urine or next-generation sequencing), have improved the knowledge of microbial communities in the urinary tract. It turned out that gut dysbiosis is strictly involved in the pathogenesis of UTIs. In particular, the human gut is the natural habitat for Escherichia coli (E. coli), the main bacterium responsible for UTIs. The overgrowth of E. coli pathogenic strains represents a risk factor for them. Furthermore, the human gut microbiota acts as a "global reservoir" for genes conferring resistance to clinically relevant antibiotics, thus influencing the treatment of UTIs. In addition, differently from the past, the idea of a sterile urinary environment has been replaced by the characterization of a urinary microbiome. The aim of our review is to explore recent studies on the association between gut microbiota and urinary microbiome and to summarize the current knowledge about the effects of interactions between gut and urinary microbial communities in the pathogenesis of UTIs, considering UTIs more as a "gut disease" and not only a urinary disease and providing new insight into the therapeutic options such as the use of probiotics. [ABSTRACT FROM AUTHOR]

Heart failure (HF) remains a significant global health challenge, affecting millions of individuals worldwide and posing a substantial burden on healthcare systems. HF is a syndrome of intricate pathophysiology, involving systemic inflammation, oxidative stress, metabolic perturbations, and maladaptive structural changes in the heart. It is influenced by complex interactions between cardiac function, systemic physiology, and environmental factors. Among these factors, the gut microbiota has emerged as a novel and intriguing player in the landscape of HF pathophysiology. The gut microbiota, beyond its role in digestion and nutrient absorption, impacts immune responses, metabolic processes, and, as suggested by evidence in the literature, the development and progression of HF. There is a bidirectional communication between the gut and the heart, often known as the gut–heart axis, through which gut microbiota-derived metabolites, immune signals, and microbial products exert profound effects on cardiovascular health. This review aims to provide a comprehensive overview of the intricate relationship between the gut microbiota and HF. Additionally, we explore the potential of using probiotics as a therapeutic strategy to modulate the gut microbiota’s composition and attenuate the adverse effects observed in HF. Conventional therapeutic approaches targeting hemodynamic and neurohormonal dysregulation have substantially improved the management of HF, but emerging research is exploring the potential implications of harnessing the gut microbiota for innovative approaches in HF treatment.

Background: Antibiotic-associated diarrhea is a condition reported in 5–35% of patients treated with antibiotics, especially in older patients with comorbidities. In most cases, antibiotic-associated diarrhea is not associated with serious complications, but it can prolong hospitalization and provoke Clostridium difficile infection. An important role in the prevention of antibiotic-associated diarrhea is carried out by some probiotic strains such as Lactobacillus GG or the yeast Saccharomyces boulardii that showed good efficacy and a significant reduction in antibiotic-associated diarrhea. Similarly, the Limosilactobacillus reuteri DSM 17938 showed significant benefits in acute diarrhea, reducing its duration and abdominal pain. Aim: The aim of this study was to test the efficacy of a mix of two probiotic strains (Limosilactobacillus reuteri LMG P-27481 and Lacticaseibacillus rhamnosus GG ATCC 53103; Reuterin GG®, NOOS, Italy), in association with antibiotics (compared to antibiotics used alone), in reducing antibiotic-associated diarrhea, clostridium difficile infection, and other gastrointestinal symptoms in adult hospitalized patients. Patients and methods: We enrolled 113 (49M/64F, mean age 69.58 ± 21.28 years) adult patients treated with antibiotics who were hospitalized at the Internal Medicine Department of the San Carlo di Nancy Hospital in Rome from January 2023 to September 2023. Patients were randomized to receive probiotics 1.4 g twice/day in addition with antibiotics (Reuterin GG® group, total: 56 patients, 37F/19M, 67.16 ± 20.5 years old) or antibiotics only (control group, total: 57 patients, 27F/30 M, 71 ± 22 years old). Results: Patients treated with Reuterin GG® showed a significant reduction in diarrhea and clostridium difficile infection. In particular, 28% (16/57) of patients in the control group presented with diarrhea during treatment, compared with 11% (6/56) in the probiotic group (p < 0.05). Interestingly, 7/57 (11%) of patients treated only with antibiotics developed clostridium difficile infection compared to 0% in the probiotic group (p < 0.01). Finally, 9% (5/57) of patients in the control group presented with vomiting compared with 2% (1/56) in the probiotic group (p < 0.05). Conclusions: Our study showed, for the first time, the efficacy of these two specific probiotic strains in preventing antibiotic-associated diarrhea and clostridium difficile infection in adult hospitalized patients treated with antibiotic therapy. This result allows us to hypothesize that the use of specific probiotic strains during antibiotic therapy can prevent dysbiosis and subsequent antibiotic-associated diarrhea and clostridium difficile infection, thus resulting in both patient and economic health care benefits.

Abstract. We briefly review recent developments in the study of the quantum nature of flavor mixing; in particular, the attention will be devoted to neutrino and neutral meson oscillations. We employ Leggett-Garg type inequalities and no-signaling-in-time conditions to probe the intrinsic quantumness of such a physical manifestation, showing how the analysis is not affected by the wave-packet spreading (for neutrinos) and the intrinsic particle instability (for mesons).

IntroductionCareer self-management behaviours are key to overcoming the challenges of entry into the labour market. Combining the Conservation of Resources and Career Self-management theories, this study delves into the concept of Career Engagement among Italian University students by examining its relationship with Support from teaching Staff and Movement Capital. We hypothesised a mediation model in which Support from Teaching Staff predicts Career Engagement which, in turn, fosters Movement Capital. As the pandemic led to the adoption of online learning solutions, we also explored whether and how the interaction between teachers and students during online classes moderates the said mediation relationship.Methods and resultsWe collected data from 276 Italian University students through an online questionnaire. Results supported the mediation hypothesis, corroborating the mediating role of Career Engagement. We also observed that this relationship is stronger at medium and higher levels of online interaction between teachers and students.DiscussionFindings contribute to existing evidence about the role of Career Engagement in facilitating career resources’ acquisition and extend the understanding of its contextual antecedents in Higher Education contexts. Results also align with the importance attributed to interaction in online learning environments. This work suggests ways to encourage career behaviours in Higher Education and equip prospective labour market entrants with career resources.

Celiac disease (CD) is a chronic inflammation of the small intestine triggered by gluten ingestion in genetically predisposed people. Recent literature studies highlight the possible role of the gut microbiota in the pathogenesis of this disease. The gut microbiota is a complex community of microorganisms that can interact with the innate and adaptative immune systems. A condition of dysbiosis, which refers to an alteration in the composition and function of the human gut microbiota, can lead to a dysregulated immune response. This condition may contribute to triggering gluten intolerance, favoring the development and/or progression of CD in genetically susceptible patients. Interestingly, studies on children and adults with CD showed a different microbiome profile in fecal samples, with a different degree of “activity” for the disease. From this point of view, our review aimed to collect and discuss modern evidence about the alteration of the gut microbiota and its modulation with probiotics, with possible future indications in the management of patients affected by CD.

The wine industry produces large amounts of grape pomace (GP), a waste that needs to be disposed of properly. Bioactive compounds with high added value can be recovered from GP as an interesting strategy to reduce the environmental impact. Here, two different technologies were employed to recover polyphenol compounds from GP: microwave hydrodiffusion and gravity (MHG) and ultrasound-assisted extraction (UAE). The further purification of UAE and MHG extracts was carried out through solid-phase extraction (SPE) to obtain three fractions, F1, F2 and F3. ATR-FTIR analysis confirmed the presence of sugar and polysaccharide components in F1, as well as non-anthocyanin and anthocyanin compounds in F2 and F3, respectively. Also, the chemical profile was determined by HPLC-UV-DAD, identifying the presence of catechin in F2, and malvidin-3-O-glucoside chloride and cyanidin chloride derivative as the main anthocyanin compounds in F3. The fractions and their parental extracts were characterized for total phenolic content (TPC) and scavenger activity by in vitro assays. We found that F2-MHG and F3-MHG contained phenol contents 6.5 and 8.5 times higher than those of the parental non-fractionated extracts. Finally, F3-MHG (100 μg/mL, w/v) was shown to reduce the proliferation of HT-29 cells.

The Energy Efficiency Directive (EED, Directive 2012/27/EU) has made mandatory the installation of individual metering systems in the case of buildings with centralized heating/cooling and hot water sources (multi-apartment and multi-purpose buildings), provided it is economically and technically feasible. Individual metering of heating/cooling systems is mainly based on thermal energy meters (TEM), which are widely used for direct metering in heating applications. On the other hand, direct metering of energy consumption in cooling systems still represents a challenge, given the different types of cooling units and the lack of regulations from the technical and legal points of view. In this context, this paper briefly overviews the available centralized cooling systems and the possible solutions for metering and sub-metering, which depend on the specific application. Vapour Compression Refrigeration (VCR) systems are spreading worldwide for air conditioning applications. Particular attention has been paid to the direct metering of cooling energy and specifically to refrigerant flow rate measurement, which represents a critical issue because of the small-diameter pipes and the different thermodynamic properties of the fluid used. Thus, an experimental campaign has been developed and carried out in order to compare a clamp-on ultrasonic flowmeter with a more accurate Coriolis one in a direct expansion (DE) system. The experimental tests have been performed at two different temperature conditions, showing a relative error in the mass flow rate measurements within ±10%.

Acute appendicitis is a common reason for admission to the Emergency Department (ED). It affects almost 70% of people under 30 years of age and 10% over 60 years of age. Its diagnosis includes the combination of clinical signs, laboratory tests and imaging. For years, surgical appendectomy has been the first-line therapy for acute appendicitis, but currently the management has shown some changes, in particular in patients with uncomplicated appendicitis. Recent studies have investigated the use of probiotics as an adjunctive therapy with promising results in conferring health benefits to patients with acute appendicitis. The aim of our review is to summarize the results of clinical studies about probiotics and the immunological response in acute appendicitis, discussing the limitations and future directions of this research.

In pursuing sustainable refrigeration solutions, integrating phase change materials (PCMs) within sun-powered refrigerators emerges as a promising avenue to mitigate challenges associated with sun radiation intermittency and reliance on large battery systems. This paper comprehensively examines incorporating PCMs into sun-powered refrigerators to address critical issues hindering the widespread adoption of solar refrigeration technologies, particularly in medicine and perishable goods. The primary objective of this study is to assess the efficacy of PCM integration in achieving grid disconnection and enabling autonomous operation of sun-powered refrigerators. Through experimentation and data analysis, our findings elucidate the transformative impact of PCM utilization on the performance and sustainability of solar refrigeration systems. Key outcomes from the experimental trials demonstrate that incorporating PCMs facilitates prolonged operation of sun-powered refrigerators, even without direct sunlight. By harnessing the thermal storage capabilities of PCMs, the refrigeration unit achieves grid independence, thereby mitigating reliance on conventional power sources and large battery configurations. In conclusion, integrating phase change materials is pivotal to achieving energy autonomy and sustainability in sun-powered refrigeration systems. Through collaborative efforts and continued innovation, PCM-enabled refrigeration technologies hold immense promise in revolutionizing cold chain logistics and enhancing global access to vital medical resources and foodstuffs. [ABSTRACT FROM AUTHOR]

The availability of vaccines, medicines, and perishable goods in remote or off-grid areas remains a formidable challenge. Integrating solar photovoltaic (PV) systems with refrigeration technology has emerged as a promising solution to address this critical need. This paper comprehensively explores a sun-powered refrigerator capable of maintaining temperatures between +2℃ and -20℃, essential for preserving vaccines, medicines and perishable products in remote areas. A solar PV panel is mounted on the refrigerator's top surface, harnessing renewable energy to power the refrigerator. This solution also enhances portability, making it well-suited to remote and resource-constrained regions. The results of initial experimental tests aim at validating feasibility and efficacy of the sun-powered refrigerator and assessing the refrigerator's performance under varying operating conditions. Detailed insights into the design, construction and limitations are provided, shedding light on its potential as a sustainable solution for vaccines and medicines storage in underserved areas. Solar availability, storage capacity, and backup power sources are carefully examined to provide a comprehensive understanding of the practical considerations and constraints involved. This paper contributes to scientific literature on renewable energy applications and aims to inform policymakers, healthcare practitioners, and technology developers about the potential and challenges of solar-powered refrigeration solutions for resource-limited areas. [ABSTRACT FROM AUTHOR]

Corporate websites are crucial in recruitment, as the prospective applicants' experiences in digital recruitment may influence their intentions. Therefore, understanding how opportunity-to-perform perceptions (OPP) integral to procedural justice experienced by potential applicants while visiting a corporate recruitment website impact their reactions towards the company can be key. This study aims to elucidate the influence of OPP on applicants' intentions to apply (ITA) via corporate websites. Specifically, it explores the indirect relationship between OPP during recruitment and ITA one month after visiting a company website, mediated by organizational attractiveness and ITA measured immediately after and one week after the website visit. This multi-wave study collected 260 cases from master's students in psychology who completed a questionnaire across waves. Hypotheses were tested using the PROCESS macro in SPSS. The findings highlighted a serial mediation pathway, wherein the indirect connection between OPP and ITA after one month was mediated through organizational attractiveness, ITA immediately after, and one week after website visits. The results highlight the importance of enhancing procedural justice corporate websites to influence applicants' perceptions and intentions positively and improve recruitment outcomes. Future research should explore the effect of long-term justice perceptions as a basis for a sustainable employee–employer relationship. [ABSTRACT FROM AUTHOR]