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181 results on '"Petrovic, O."'

61. Child development in developing countries: introduction and methods.

Author

Bornstein MH, Britto PR, Nonoyama-Tarumi Y, Ota Y, Petrovic O, Putnick DL, Bornstein, Marc H, Britto, Pia Rebello, Nonoyama-Tarumi, Yuko, Ota, Yumiko, Petrovic, Oliver, and Putnick, Diane L

Abstract

The Multiple Indicator Cluster Survey (MICS) is a nationally representative, internationally comparable household survey implemented to examine protective and risk factors of child development in developing countries around the world. This introduction describes the conceptual framework, nature of the MICS3, and general analytic plan of articles in this Special Section. The articles that follow describe the situations of children with successive foci on nutrition, parenting, discipline and violence, and the home environment. They address 2 common questions: How do developing and underresearched countries in the world vary with respect to these central indicators of children's development? How do key indicators of national development relate to child development in each of these substantive areas? The Special Section concludes with policy implications from the international findings. [ABSTRACT FROM AUTHOR]

Published
2012
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63. Learning Mobile App Design From User Review Analysis.

Author

Platzer, E. and Petrovic, O.

Subjects
MOBILE app development, CELL phone users, CLASSROOM environment, CREATIVE ability, SYSTEMS engineering, CONTENT analysis
Abstract

This paper presents a new learning environment for developers of mobile apps that merges two quite different views of the same topic. Creative design and system engineering are core issues in the development process that are based on diverging principles. This new learning environment aims to address both points of view by not suppressing one of them but trying to benefit from both. User review content analysis is introduced as a tool to generate information that is useful for both aspects. [ABSTRACT FROM AUTHOR]

Published
2011
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64. The prevalence of live birth Down syndrome in the region of Primorsko-goranska County in Croatia, 1996-2005: the impact of screening and amniocentesis.

Author

Brajenovic-Milic B, Prpic I, Petrovic O, Ristic S, Brumini G, and Kapovic M

Abstract

Objectives To investigate the prevalence of live birth Down syndrome (DS) in the region of Primorsko-goranska County (PGC) in Croatia from 1996 to 2005 and to evaluate the impact of second-trimester maternal serum screening (MSS) and amniocentesis on live birth DS prevalence. Methods Study was based on databases from the Department of Gynecology and Obstetrics, University Hospital Centre Rijeka, the Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, and the Croatian National Institute of Public Health. The regional policy of prenatal diagnosis for DS includes amniocentesis for pregnant women aged 35 or over and MSS for younger women. We estimated live birth and total prevalence of DS and measured the proportion of pregnant women using MSS and amniocentesis. Trends of live birth and total prevalence of DS were tested by linear regression analysis. Results The live birth prevalence of DS was 1.4/1000 in the period 1996-2005. A decreasing, but nonsignificant, trend of prevalence was observed over time (P = 0.577). Women aged 35 or over represented 11.6% of all pregnant women included in the study. The proportion of women who had MSS was 33.9%. The proportion who underwent amniocentesis was 6.1%. Conclusions No marked decrease in prevalence of live birth DS was observed in the region of PGC during the last 10 years. The usage of MSS and amniocentesis was too low to have any significant impact on live birth DS prevalence. Women's, as well as physician's, knowledge and attitudes towards prenatal diagnosis of DS should be evaluated. [ABSTRACT FROM AUTHOR]

Published
2008
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70. A Multi-Microprocessor Based Distance Relay: Design Requirements and Implementation Characteristics

Author

Kezunovic, M., Kreso, S., and Petrovic, O.

Abstract

This paper describes a Multi-microprocessor Based Distance Relay implementation. Design requirements are outlined first. Detailed discussion of system, maintenance and testing, interface and cost/performance requirements is given. Second part of the paper provides an overview of the implementation characteristics. System architecture, hardware, software and algorithm issues are presented. Finally, a conclusion is drawn related to the major advantages of the design as well as to the future testing and evaluation procedures.

Published
1985
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76. Poster session 2

Author

Martins Fernandes, S, Teixeira, R, Roussin, I, Lynch, M, Badano, L, Muraru, D, Romeo, G, Ermacora, D, Marotta, C, Aruta, P, Cucchini, U, Iliceto, S, Garcia Campos, A, Martin-Fernandez, M, De La Hera Galarza, JM, Corros-Vicente, C, Colunga Blanco, S, Velasco-Alonso, E, Leon-Aguero, V, Rodriguez-Suarez, ML, Moris De La Tassa, C, Erdei, T, Edwards, J, Braim, D, Price, C, Fraser, AG, Cardiff, Investigators, MEDIA, Mehdipoor, G, Salmani, F, Arjmand Shabestari, A, Hanboly, N, Michalski, BW, Szymczyk, E, Kupczynska, K, Peczek, L, Nawrot, B, Lipiec, P, Kasprzak, JD, Vriz, O, Driussi, C, Ferrara, F, Brosolo, G, Antonini-Canterin, F, Magne, J, Aboyans, V, Bossone, E, Mo, VY, Bellucci, BM, Fisher, JM, Balekian, AA, Le, T T, Idapalapati, S, Huang, F, Wong, JI, Tan, RS, Ribeiro, JM, Teixeira, R, Madeira, M, Almeida, I, Reis, L, Siserman, A, Dinis, P, Dias, L, Ramos, AP, Goncalves, L, Ternacle, J, Wan, FW, Sawaki, DS, Dubois-Rande, JLDR, Adnot, SA, Czibik, GC, Derumeaux, GD, Yurdakul, SELEN, Ercan, G, Tekkesin, ILKER, Sahin, ST, Cengiz, B, Celik, G, Demircan, S, Aytekin, SAIDE, Shetye, A, Razvi, NA, Nazir, SA, Price, N, Khan, JN, Kanagala, P, Singh, A, Squire, I, Mccann, GP, Stoebe, S, Langel, M, Pfeiffer, D, Hagendorff, A, Lisowska, A, Ptaszynska-Kopczynska, K, Marcinkiewicz-Siemion, M, Knapp, M, Witkowski, M, Musial, WJ, Kaminski, K, Chinali, M, Natali, B, D' Anna, C, Leonardi, B, Secinaro, A, Pongiglione, G, Rinelli, G, Orabona, M, Renard, S, Michel, N, Mancini, J, Haentjens, J, Sitbon, O, Habib, G, Contaldi, C, Imbriaco, M, Alcidi, G, Santoro, C, Buonauro, A, Lo Iudice, F, Lembo, M, Cuocolo, A, Trimarco, B, Galderisi, M, De La Chica, JA, Mora Robles, J, Roldan Jimenez, MA, Mancisidor, MA, De Mora, MA, Codolosa, JN, Alnabelsi, T, Goykhman, I, Koshkelashvili, N, Romero-Corral, A, Pressman, GS, Trzcinski, P, Michalski, BW, Kupczynska, K, Miskowiec, D, Lipiec, P, Kasprzak, JD, Prado Diaz, S, Montoro Lopez, N, Refoyo Salicio, E, Valbuena Lopez, SC, Gonzalez, O, Alvarez, C, Moreno Yanguela, M, Bartha Rasero, JL, De La Calle, M, Guzman Martinez, G, Morales Portano, J D, Suarez-Cuenca, JA, Merino, JA, Gomez Alvarez, E B, Delgado, LG, Ha, SJ, Woo, YM, Bang, WD, Sohn, GH, Cheong, SS, Yoo, SY, Valente, F, Rodriguez Palomares, JF, Gutierrez, L, Maldonado, G, Pineda, V, Galian, L, Teixido, G, Gonzalez Allujas, MT, Evangelista, A, Garcia Dorado, D, Joseph, G, Zaremba, T, Ekeloef, S, Heiberg, E, Engblom, H, Jensen, SE, Sogaard, P, Valente, F, Rodriguez Palomares, JF, Gutierrez, L, Garcia, G, Pineda, V, Galian, L, Teixido, G, Gonzalez Allujas, MT, Evangelista, A, Garcia Dorado, D, Scali, MC, Dini, FL, Galli, F, Lattanzi, F, Picano, E, Marzilli, M, Cordeiro, F, Leao, S, Moz, M, Magalhaes, P, Trigo, J, Mateus, PS, Ferreira, A, Moreira, JI, Duchateau, N, De Craene, M, Legallois, D, Labombarda, F, Pellissier, A, Sermesant, M, Saloux, E, Fabris, E, Merlo, M, Moretti, M, Barbati, G, Stolfo, D, Gigli, M, Pinamonti, B, Sinagra, G, Costantino, MF, Dores, E, Matera, A, Innelli, P, Innelli, P, Lopizzo, A, Violini, R, Fiorilli, R, Cappabianca, G, Picano, E, Tarsia, G, Cho, I J, Seo, J, Chang, HJ, Heo, R, Kim, IC, Shim, CY, Hong, GR, Chung, N, Goublaire, C, Melissopoulou, MM, Nguyen, V, Brochet, E, Cimadevilla, C, Codogno, I, Vahanian, A, Messika-Zeitoun, D, Lam, W, Pontana, F, Vassiliou, V, Prasad, S, Galli, E, Leclercq, C, Samset, E, Donal, E, Kim, KH, Lim, DS, Mariani, M, Bianchi, G, Rossi, F, Gianetti, J, Marchi, F, Cerone, E, Nardelli, A, Terrazzi, M, Solinas, M, Maffei, S, Malev, E, Pshepiy, A, Vasina, L, Timofeev, E, Reeva, S, Zemtsovsky, E, Zuercher, F, Brugger, N, Jahren, S, De Marchi, SF, Seiler, C, Tang, Z, Jin, CN, Tang, H, Fan, K, Kam, K, Yan, BP, Yu, CM, Lee, PW, Cimino, S, Reali, M, Silvetti, E, Salatino, T, Mancone, M, Pennacchi, M, Giordano, A, Sardella, G, Agati, L, Mahia, P, Tirado, G, Nogales-Romo, MT, Marcos-Alberca, P, De Agustin, A, Almeria, C, Rodrigo, JL, Garcia Fernandez, MA, Macaya, C, Perez De Isla, L, De La Chica, JA, Mancisidor, M, Lara Garcia, C, Vivancos, R, De Mora, M, Petrovic, J, Petrovic, M, Vujisic-Tesic, B, Trifunovic, D, Boricic-Kostic, M, Petrovic, I, Draganic, G, Petrovic, O, Tomic-Dragovic, M, Ciobotaru, V, Remsey- Semmelweiss, E, Kogoj, P, Furlan, T, Ambrozic, J, Mohorko Pleskovic, PN, Bunc, M, Guerreiro, S, Ribeiras, R, Abecasis, J, Andrade, MJ, Mendes, M, Saxena, A, Ramakrishnan, S, Gupta, SK, Juneja, R, Kothari, SS, Mozenska, O, Zaleska, M, Segiet, A, Chwesiuk, S, Kroc, A, Kosior, DA, Pontone, G, Andreini, D, Solbiati, A, Guglielmo, M, Mushtaq, S, Baggiano, A, Beltrama, V, Rota, C, Guaricci, AI, Pepi, M, Macaya Ten, F, Pons Llinares, J, Asmarats Serra, L, Pericas Ramis, P, Caldes Llull, O, Grau Sepulveda, A, Frontera, G, Vaquer Segui, A, Noris, M, Bethencourt Gonzalez, A, Caballero, L, Climent Paya, V, Martinez Moreno, M, Saura, D, Oliva, MJ, Sanchez Quinones, J, Garcia Honrubia, A, Valdes, M, De La Morena, G, Avegliano, G, Terricabras, M, Costabel, JP, Ronderos, R, Evangelista, A, Venturini, C, Galve, E, Halmai, L, Nemes, A, Neubauer, S, Rahman Haley, S, Banner, N, Reis, L, Teixeira, R, Caetano, F, Almeida, I, Trigo, J, Botelho, A, Silva, J, Nascimento, J, Goncalves, L, Trifunovic, D, Tesic, M, Jovanovic, I, Petrovic, O, Boricic-Kostic, M, Dragovic, M, Petrovic, M, Stepanovic, J, Banovic, M, Vujisic-Tesic, B, Gospodinova, M, Guergelcheva, V, Chamova, T, Sarafov, S, Tournev, I, Denchev, S, Makavos, G, Ikonomidis, I, Psarogiannakopoulos, P, Tsirigotis, P, Paraskevaidis, I, Lekakis, J, D'ascenzi, F, Pelliccia, A, Natali, BM, Cameli, M, Focardi, M, Bonifazi, M, Mondillo, S, Dantas Tavares De Melo, M, Lima, C, Assed, L, Kalil Filho, R, Mady, C, Bochi, E A, Salemi, V M C, Bonapace, S, Targher, G, Valbusa, F, Rossi, A, Lanzoni, L, Lipari, P, Zenari, L, Molon, G, Canali, G, Barbieri, E, Kulkarni, A, Li, L, Craft, M, Nanda, M, Lorenzo, JM, Kutty, S, Cameli, M, Bombardini, T, Sparla, S, Di Tommaso, C, Losito, M, Incampo, E, Maccherini, M, Mondillo, S, Ingvarsson, A, Werther Evaldsson, A, Radegran, G, Stagmo, M, Waktare, J, Roijer, A, Meurling, CJ, Driessen, MMP, Hui, W, Meijboom, FJ, Bijnens, B, Dragulescu, A, Mertens, L, Friedberg, MK, Tufekcioglu, O, Sensoy, B, Suleymanoglu, M, Akin, Y, Sahan, E, Sasmaz, H, Radulescu, D, Pasca, L, Buzdugan, E, Chis, B, Stoicescu, L, Barac, A, Lynce, FC, Smith, KL, Mete, M, Isaacs, C, Cioffi, G, Viapiana, O, Di Nora, C, Ognibeni, F, Fracassi, E, Giollo, A, Mazzone, C, Faganello, G, Di Lenarda, A, Rossini, M, Almeida Morais, L, Galrinho, A, Branco, L, Timoteo, A T, Rodrigues, I, Daniel, P, Rosa, S, Ferreira, L, Ferreira, R, Ledakowicz-Polak, A, Polak, L, Krauza, G, Stokfisz, K, Zielinska, M, Portugal, G, Branco, L M, Galrinho, A, Mota Carmo, M, Teresa Timoteo, A, Aguiar Rosa, S, Abreu, J, Pinto Teixeira, P, Viveiros Monteiro, A, Cruz Ferreira, R, Naksuk, N, Peeraphatdit, T, Chaiteerakij, R, Klarich, KW, Parato, V M, Masia, S, Kovalova, S, Necas, J, Cherubini, A, Nistri, S, Negri, F, Barbati, G, Cioffi, G, Russo, G, Mazzone, C, Faganello, G, Pandullo, C, Di Lenarda, A, Corrado, G, Durante, A, Rovelli, E, Genchi, V, Trabattoni, L, Zerboni, SC, Cattaneo, L, Butti, E, Ferrari, G, Malev, E, Luneva, E, Mitrofanova, L, Uspensky, V, Zemtsovsky, E, Wierzbowska-Drabik, K, Kasprzak, JD, Lesevic, H, Rosner, S, Karl, M, Ott, I, Sonne, C, Laredj, N, Ali Lahmar, HM, Hammou, L, Pieles, G E, Forsey, J, Gowing, L, Miller, F, Ramanujam, P, Stuart, AG, Williams, CA, Generati, G, Bandera, F, Pellegrino, M, Carbone, F, Labate, V, Alfonzetti, E, Guazzi, M, Van Zalen, JJ, Patel, NR, Raju, P, Beale, L, Brickley, G, Lloyd, GW, Aquila, I, Fernandez-Golfin, C, Gonzalez, A, Rincon, LM, Hinojar, R, Garcia, A, Megias, A, Jimenez-Nacher, JJ, Moya, JL, Zamorano, JL, Cheng, H-L, Lanzoni, L, Molon, G, Canali, G, Bonapace, S, Chiampan, A, Albrigi, L, Barbieri, E, Asmarats Serra, L, Noris Mora, M, Rodriguez Fernandez, A, Exposito Pineda, C, Grande, C, Gonzalez Colino, R, Macaya Ten, F, Fernandez Vazquez, X, Fortuny Frau, E, Bethencourt Gonzalez, A, Kadrabulatova, S, Ranjbar, S, Karvandi, M, Szczesniak-Stanczyk, D, Blaszczyk, R, Zarczuk, R, Brzozowski, W, Janowski, M, Wysokinski, A, Stanczyk, B, Consortium, ReMeDi, Sharka, I, Myftiu, S, Teferici, D, Quka, A, Dado, E, Djamandi, J, Kresto, L, Duka, A, Kristo, A, Balla, I, Di Salvo, G, Issa, Z, Moiduddin, N, Siblini, G, Bulbul, Z, Ben Kahla, S, Abid, L, Abid, D, Kammoun, S, Li, L, Rush, E, Craft, M, Goodwin, J, Kreikemeier, R, Cantinotti, M, Kutty, S, Hadeed, HA, Zolaly, M A, Khoshhal, SQ, El-Harbi, K, Tarawah, A, Al-Hawsawi, Z, Al-Mozainy, I, Habeeb, H A, Bakhoum, S W G, Nabil, M N, Elebrashy, I N, Toscano, A, Chinali, M, Albanese, S, Carotti, A, Iacobelli, R, Esposito, C, Secinaro, A, Moscogiuri, G, Pasquini, L, Granata, F, Malvezzi Caracciolo, M, Bianchi, RM, Caso, P, Arenga, F, Riegler, L, Scarafile, R, D'andrea, A, Russo, MG, Calabro', P, Djikic, D, Simic, DS, Peric, VP, Mujovic, NM, Marinkovic, MM, Jankovic, NJ, Wdowiak-Okrojek, K, Shim, A, Wejner-Mik, P, Kasprzak, JD, Lipiec, P, Girgis, H Y A, Sharma, A, Jain, N, Kharwar, R, Saran, RK, Narain, VS, Dwivedi, SK, Sethi, R, Chandra, S, Pradhan, A, Safal, S, Soro, C, Marchetti, MF, Cacace, C, Congia, M, Nissardi, V, Ruscazio, M, Meloni, L, Montisci, R, Gallego Page, J C, Gallego Sanchez, G, Calero, S, Portero, JJ, Tercero, A, Garcia, JC, Barambio, M, Martinez Lazaro, R, Corneli, M, Meretta, AH, Perea, GO, Belcastro, F, Aguirre, E, De Luca, I, Henquin, R, and Masoli, O

Abstract

Introduction: The relationship between the appropriateness of the transthoracic echocardiography (TTE) and its clinical impact is still a matter of debate. Objective: The aim of this study was to assess the degree of adherence to the appropriate use criteria for echocardiography, in a tertiary public hospital in the United Kingdom, as well as the clinical impact of the exam on patient management. Methods: 859 TTE’s performed consecutively during January 2014 were reviewed to assess its appropriateness, and were classified as appropriate, uncertain or inappropriate using the 2011 guidelines. Subsequently, patient’s files were examined to determine the clinical impact of the TTE which was assigned to one of the following three categories: (1) active change in care, (2) continuation of current care, or (3) no change in care. Patients which files were not available were excluded (259). All classifications were evaluated by two independent cardiologists, with no direct relation to the study. Results: Our sample had a mean age of 63 ± 17 years with a gender balance. The majority of the exams were requested at the outpatient (81.4%) clinic, by cardiologists (50.3%) and general practitioners (13.4%). Regarding the main findings, in 7.6% of the studies there were moderate to severe systolic dysfunction; 4.0% showed severe valvular heart disease and 5.1% had significant pulmonary hypertension. Relatively to the appropriateness of the TTE requests, 76.5% were considered appropriate, 7.1% inappropriate and 12.6% uncertain. With respect to the clinical impact of the TTE’s, 42.7% of the exams led to an active change in care, 15.6% to a continuation of the care and 11.5% revealed no change in care. Age (β0.90, P=0.05) and outpatient setting (β4.4, P<0.01) were the most important predictors of an active change of care exam. On the contrary, the appropriateness of the TTE’s requests (β1.1, P=0.56) and the specialist ordering the exams (β0.81, P=0.26) were not independently associated. Conclusion: Our data showed that almost 8 out of 10 TTE were considered appropriate, and 4 out of 10 exams had an active clinical impact.

Published
2015
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80. Poster session 1

Author

Haberka, M, Banska, K, Gasior, Z, Garcia Martin, A, Moya-Mur, JL, Carbonell-San Roman, S-A, Rodriguez-Munoz, D, Garcia-Lledo, A, Casas-Rojo, E, Hinojar, R, Jimenez-Nacher, JJ, Fernandez-Golfin, C, Zamorano-Gomez, JL, Barbier, P, Ravani, A, Cefalu, C, Maltagliati, A, Frigerio, B, Sansaro, D, Amato, M, Baldassarre, D, Pellegrino, M, Bandera, F, Generati, G, Labate, V, Alfonzetti, E, Guazzi, M, Angelis, A, Aggeli, K, Ioakeimidis, N, Abdelrasoul, M, Felekos, I, Gourgouli, I, Aznaouridis, K, Rousakis, G, Vlachopoulos, C, Tousoulis, D, Howlett, PJ, Darasz, K, Mahmoudi, M, Shah, N, Jabr, RI, Hickman, M, Leatham, EW, Fry, CH, PREDICT-PAF, Madeira, M, Teixeira, R, Almeida, I, Caetano, F, Fernandes, A, Cassandra, M, Reis, L, Costa, M, Goncalves, L, Carrero, PJ, Nielsen, AJ, Carrero, MC, Saubidet, GL, Peralta, SP, Argentina, Aorta Abdominal, Hansen, KL, Moeller-Soerensen, H, Kjaergaard, J, Jensen, MB, Lund, JT, Pedersen, MM, Olesen, JB, Jensen, JA, Nielsen, MB, Trunina, I, Sharykin, AS, Karelina, EV, Telezhnikova, ND, Basar, C, Ozhan, H, Kayapinar, O, Albayrak, ES, Lie, OH, Saberniak, J, Dejgaard, L, Nestaas, E, Edvardsen, T, Haugaa, KH, Sade, LE, Bal, U, Eroglu, S, Pirat, B, Muderrisoglu, H, Gopal, A S, Muthukumar, L, Saha, SK, Toole, RS, Klug, G, Reinstadler, S, Feistritzer, HJ, Pernter, B, Mayr, A, Franz, WM, Mueller, S, Metzler, B, Rodriguez Gonzalez, E, Mingo Santos, S, Palomero Monivas, V, Gonzalez Mirelis, J, Goirigolzarri Artaza, J, Zorita Gil, B, Fernandez Diaz, JA, Goicolea Ruigomez, J, Restrepo Cordoba, MA, Alonso Pulpon, L, Ferrara, F, Gargani, L, D'alto, M, Ghio, S, Acri, E, Carannante, L, Argiento, P, D'andrea, A, Vriz, O, Bossone, E, Moustafa, S, Ho, TH, Shah, P, Murphy, K, Nelluri, BK, Lee, H, Wilansky, S, Mookadam, F, Naksuk, N, Peeraphatdit, T, Chaiteerakij, R, Klarich, KW, Cantinotti, M, Scalese, M, Melo, M, Assanta, N, Marotta, M, Crocetti, M, Spadoni, I, Giordano, R, Kutty, S, Iervasi, I, Michelsen, MM, Mygind, ND, Pena, A, Frestad, D, Hoest, N, Prescott, E, Fernandes, JMG, Romao, BO, Rivera, IR, Mendonca, MA, Carvalho, AC, Campos, O, Amato, A, Moises, VA, Demir, OM, Bashir, A, Marshall, K, Douglas, M, Wasan, B, Plein, S, Alfakih, K, Cano Carrizal, R, Casanova Rodriguez, C, Cadenas Chamorro, R, Iglesias Del Valle, D, Martin-Penato Molina, A, De Juan Baguda, J, Prieto Moriche, E, Garcia Garcia, A, De La Cruz Berlanga, E, Plaza Perez, I, Bouzas-Mosquera, A, Peteiro, J, Broullon, FJ, Alvarez-Garcia, N, Barbeito-Caamano, C, Larranaga-Moreira, JM, Maneiro-Melon, N, Martinez-Ruiz, D, Yanez, JC, Vazquez-Rodriguez, JM, Leao, S, Cordeiro, F, Magalhaes, P, Moz, M, Trigo, J, Mateus, P, Fontes, P, Moreira, I, Kuznetsov, VA, Krinochkin, DV, Plusnin, AV, Soldatova, AM, Nazir, S A, Shetye, A, Khan, JN, Singh, A, Kanagala, P, Swarbrick, DJ, Graham-Brown, M, Mccann, GP, Trifunovic, D, Krljanac, G, Savic, L, Asanin, M, Aleksandric, S, Lasica, R, Srdic, M, Zlatic, N, Petrovic, M, Mrdovic, I, Rodriguez Gonzalez, E, Mingo Santos, S, Monivas Palomero, V, Gonzalez Mirelis, J, Zorita Gil, B, Fernandez Diaz, JA, Restrepo Cordoba, MA, Goirigolzarri Artaza, J, Rivero Arribas, B, Goicolea Ruigomez, J, Spampinato, RA, Dobrovie, M, Da Rocha E Silva, JG, Bonamigo Thome, F, Kluttig, R, Schloma, V, Dmitrieva, Y, Strotdrees, E, Mohr, FW, Antonini-Canterin, F, Luzza, G, Caruso, R, Belfiore, R, Della Mattia, A, Poli, S, Vriz, O, Zito, C, La Carrubba, S, Carerj, S, Ribeiro, JM, Teixeira, R, Goncalves, L, Morgado, GJ, Carvalho, JF, Gomes, AC, Caldeira, D, Cruz, IR, Stuart, B, Maia, R, Fazendas, P, Pereira, H, Trifunovic, D, Rakocevic, I, Tutos, V, Petrovic, O, Petrovic, M, Boricic-Kostic, M, Stepanovic, J, Jovanovic, I, Banovic, M, Vujisic-Tesic, B, Reis, L, Teixeira, R, Leite, L, Fernandes, A, Cassandra, M, Madeira, M, Botelho, A, Santos, M, Nascimento, J, Goncalves, L, Naratrekoon, B, Yingchoncharoen, T, Vathesatogkit, P, Yamwong, S, Sritara, P, Soto-Ruiz, RM, Bonaque Gonzalez, J C, Abellan-Huerta, J, Rubio-Paton, R, Soria, F, Ramos, JL, Egea, S, Garcia-Gomez, J, Martinez Diaz, JJ, Castillo, JA, Penicka, M, Vecera, J, Mirica, C, Kotrc, M, Kockova, R, Zilberszac, R, Gabriel, H, Maurer, G, Rosenhek, R, De Chiara, B, Botta, L, Musca, F, Belli, O, Costetti, A, Trolese, I, Spano, F, Russo, C, Giannattasio, C, Moreo, A, Rifai, R, Berthelot, E, Le, MT, Hilpert, L, Montani, D, Sitbon, O, Jais, X, Humbert, M, Assayag, P, Gunduz, S, Yesin, M, Kalcik, M, Gursoy, MO, Cersit, S, Astarcioglu, MA, Karakoyun, S, Aykan, AC, Ozkan, M, Cersit, S, Gunduz, S, Tabakci, M, Kalcik, M, Yesin, M, Bayam, E, Ozkan, M, Devecchi, C, Degiovanni, A, Di Ruocco, MV, Marino, P, Ancona, F, Rosa, I, Stella, S, Barletta, M, Marini, C, Latib, A, Montorfano, M, Colombo, A, Margonato, A, Agricola, E, Smith, D, Ray, R, Gallagher, M, Nazir, M, Perreso, V, Sharma, R, Gargani, L, Pang, PS, Miglioranza, M, Landi, P, Dini, FL, Picano, E, Asmarats Serra, L, Pons Llinares, J, Macaya Ten, F, Pericas Ramis, P, Caldes Llull, O, Grau Sepulveda, A, Frontera, G, Bethencourt, A, Abreu, A, Santa Clara, H, Santos, V, Oliveira, M, Cunha, P, Portugal, G, Rio, P, Branco, L, Ferreira, R, Mota Carmo, M, Ikonomidis, I, Paraskevaidis, I, Papadopoulos, C, Stasinos, V, Parissis, J, Lekakis, J, Biernacka, B, Rubis, P, Gackowski, A, Wisniowska-Smialek, S, Lesniak-Sobelga, A, Kostkiewicz, M, Gomes, AC, Bento, D, Correia, E, Teles, L, Picarra, B, Lourenco, C, Faria, R, Magalhaes, P, Domingues, K, Azevedo, O, Caballero, L, Climent Paya, V, Martinez Moreno, M, Gimeno, JR, Oliva, MJ, Saura, D, Sanchez Quinones, J, Garcia Honrubia, A, Valdes, M, De La Morena, G, Mansencal, N, Richard, P, Guerard, S, Brion, R, Paul, P, Dubourg, O, Komajda, M, Isnard, R, Arslan, M, Charron, P, Venturini, C, Avegliano, G, Andres, S, Costabel, JP, Kuschnir, P, Sciancalepore, A, Mendoza, O, Perea, G, Ronderos, R, Zaroui, A, Ben Said, RYM, EL Chalbia, TEJ, Wali, SANA, Mourali, MS, Mechmeche, RACHID, Leren, I S, Saberniak, J, Haland, TF, Edvardsen, T, Haugaa, KH, Astrom Aneq, M, Svetlichnaya, J S, Shikha, SS, Scheinmann, MS, Klein, LK, Nucifora, G, Prati, G, Vitrella, G, Allocca, G, Cukon Buttignoni, S, Muser, D, Morocutti, G, Pinamonti, B, Sinagra, G, Proclemer, A, Rocon, CRLA, Melo, MDTM, Bocchi, EAB, Araujo, JABAF, Demarchi, LMMFD, Mady, CM, Biselli, BB, Kalil, RKF, Salemi, VMCS, Tuma, RT, Cho, J Y, Kim, K H, Yoon, H J, Lee, K J, Park, H, Kim, J H, Ahn, Y, Jeong, M H, Cho, J G, Park, J C, Cho, J Y, Kim, K H, Yoon, H J, Park, H J, Kim, J H, Ahn, Y, Jeong, M H, Cho, J G, Park, J C, Sade, LE, Kozan, H, Eroglu, S, Pirat, B, Sezgin, A, Aydinalp, A, Muderrisoglu, H, Stampfli, S F, Oezkartal, T, Bernhart, S, Flammer, AJ, Vecchiati, A, Froehlich, GM, Ruschitzka, F, Tanner, FC, Cho, EJ, Choi, KY, Kim, DB, Jang, SW, Cho, JS, Park, CS, Jung, HO, Jeon, HK, Youn, HJ, Stevanovic, A, Dekleva, M, Pena, J L, Fortes, PRL, Passos, BR, Rodrigues, AB, Sampaio, IH, Oliveira, MCN, Silva, MG, Cardoso, RAF, Tofani, FA, Moreira, MCV, Ognibeni, F, Cioffi, G, Viapiana, O, Dalbeni, A, Fracassi, E, Di Nora, C, Cherubini, A, Mazzone, C, Di Lenarda, A, Rossini, M, Colunga, S, Corros, C, Garcia-Campos, A, Martin, M, Rodriguez-Suarez, M, Leon, V, Fidalgo, A, Lopez-Iglesias, F, Moris, C, De La Hera, JM, Borowiec, A, Dabrowski, R, Wozniak, J, Jasek, S, Chwyczko, T, Kowalik, I, Musiej-Nowakowska, E, Szwed, H, Hristova, K, Marinov, R, Stamenov, G, Mihova, M, Chacheva, K, Persenska, S, Racheva, A, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Karolko, B, Mysiak, A, Marwick, TH, Lesniak-Sobelga, A M, Kostkiewicz, M, Wisniowska-Smialek, S, Biernacka, B, Rubis, P, Kaldararova, M, Tittel, P, Kardos, M, Vrsanska, V, Ondriska, M, Hraska, V, Nosal, M, Masura, J, Simkova, I, Stanojevic, D, Apostolovic, S, Salinger-Martinovic, S, Jankovic-Tomasevic, R, Djordjevic-Radojkovic, D, Stanojlovic, T, Atanaskovic, V, Pavlovic, M, Tahirovic, E, Dungen, HD, Carbonell San Roman, A, Moya Mur, JL, Rodriguez-Munoz, D, Lozano Granero, C, Jimenez Nacher, JJ, Gonzalez Gomez, A, Fraile Sanz, C, Segura De La Cal, T, Fernandez-Golfin, C, Zamorano Gomez, JL, Hoetink, A, Jansen Klomp, WW, Van 'T Hof, AWJ, Brandon Bravo Bruinsma, GJ, Spanjersberg, AJ, Grandjean, J, Nierich, AP, Ferreira, R, Ferreira, J, Lazaro Mendes, S, Martins, R, Monteiro, S, Pego, M, Rohani, A, Khamene Bagheri, R, Wierzbowska-Drabik, K, Peruga, JZ, Sobczak, M, Plewka, M, Wcislo, T, Krecki, R, Kasprzak, JD, Carvalho, J F, Morgado, G, Cruz, I, Caldeira, D, Almeida, AR, Joao, I, Lopes, L, Fazendas, P, Cotrim, C, Pereira, H, Cherubini, A, Cioffi, G, Mazzone, C, Faganello, G, Pandullo, C, Russo, G, Stefenelli, C, Furlanello, F, Tarantini, L, Di Lenarda, A, Teramoto, K, Suzuki, K, Satoh, Y, Minami, K, Mizukoshi, K, Kamijima, R, Kou, S, Takai, M, Izumo, M, Akashi, YJ, May, CJH, Ayuk, J, Geh, I, Shah, T, Edwards, NC, Steeds, RP, Wejner-Mik, P, Sobczak, M, Miskowiec, D, Wdowiak-Okrojek, K, Kasprzak, JD, Lipiec, P, Gurzun, M M, Rosca, M, Calin, A, Beladan, C, Serban, M, Ginghina, C, Popescu, BA, Perea, GO, Lombardero, M, Henquin, R, Corneli, M, Tinetti, M, Laveau, F, Hekimian, G, Achkar, M, Isnard, R, Combes, A, Hammoudi, N, Mahmoud, HM, Al-Ghamdi, M, Ghabashi, A, Ezzat, M H, Al-Amin, A, Sanz, M, Giraldeau, G, Sarvari, SI, Marin, J, Brambila, C, Gabrielli, L, Bijnens, B, Sitges, M, Sanchez-Martinez, S, Duchateau, N, Erdei, T, Fraser, A, Bijnens, B H, Piella, G, Montserrat, S, Sanchis, L, Borras, R, Vidal, B, Prat, S, Azqueta, M, Pare, C, Grazioli, G, Sanz, M, Sitges, M, Kowalczyk, E, Kasprzak, JD, Wejner-Mik, P, Wdowiak-Okrojek, K, Lipiec, P, Park, CS, Jung, MH, Ahn, HS, Kim, JH, Cho, JS, Jeon, HK, Youn, HJ, Hinojar, R, Fernandez-Golfin, C, Megias, A, Alonso, GL, Gonzalez-Gomez, A, Rincon, LM, Esteban, A, Fernandez Mendez, MA, Barrios, V, Zamorano, JL, Van Berendoncks, A M, Van Gaal, L, De Block, C, Salgado, R, Vrints, C, Shivalkar, B, Guedes, H, Pereira, A, Santos, R, Marques, L, Moreno, N, Carvalho, R, Pires, M, Sousa, R, Andrade, A, Pinto, P, Nestaas, E, Stoylen, A, Fugelseth, D, Onut, R, Tautu, O, Onciul, S, Marinescu, C, Zamfir, D, Dorobantu, M, Moran, L, Sanchez Sanchez, V, Navas, P, Garcia-Cosio, D, Diaz, B, Carballo-Alzola, L, Lombera, F, Delgado, J, Kisko, A, Babcak, M, Kishko, N, Agmon, Y, Eitan, A, Mutlak, D, Kehat, I, Corneli, M, Meretta, AH, Perea, GO, Belcastro, F, Aguirre, E, Rosa, D, Zaefferer, P, Masoli, O, Peovska Mitevska, IPM, Srbinovska, ES, Bosevski, MB, Antova, EA, Pop Gorceva, DPG, Barreiro Perez, M, Martin Fernandez, M, Costilla Garcia, SM, Diaz Pelaez, E, and Moris De La Tassa, C

Abstract

Background: The attainment of the primary (low density lipoprotein cholesterol; LDL-C) and the secondary (non-high density lipoprotein cholesterol; non-HDL) lipid therapeutic targets may depend on several potential factors. Our aim was assess the associations between ultrasound fat indexes, lipid levels and the lipid goals attainment in high and very high cardiovascular (CV) risk patients. Methods: Four hundred twenty (n=420) patients (F/M=146/274; age=61 ± 7 y.o.) with high (43%) or very high (57%) cardiovascular risk and chronic statin treatment (³12 months) were enrolled into the study. Obesity measures (body-mass index, BMI; bioelectrical impedance body fat; BF, waist circumference, WC, body adiposity index; BAI), serum levels of lipids (total cholesterol–TC, LDL-C, HDL-C and triglycerides–TG) and goal lipid levels (LDL-C and non-HDL-C) according to the CV risk were determined in all patients. The following ultrasound fat parameters were used in the study: intraabdominal fat (IAT), preperitoneal fat thickness (PreFT), epicardial (EFT) and pericardial (PFT) fat thickness and were indexed to BMI. Results: Our study patients had 5.2 ± 1.7 CV risk factors (80% hypertension, 32% diabetes, 59% metabolic syndrome), 49% were obese, 63% had high BF% and 85% had increased waist circumference (F>80 or M>94cm). All the patients were on a long-term statin treatment (rosuvastatin, atorvastatin or simvastatin). The attainment of the target lipid levels in the study group was as follows: LDL-C–34%, non-HDL-C–39%, both LDL-C and non-HDL-C 31%. Mean fat parameters in the study group were as follows: IAT–76.4 ± 26mm, PreFT–23.3 ± 6.5mm, EFT–3.5 ± 1.5mm and PFT–8.6 ± 3.8mm. Patients with LDL-C goal attainment had significantly higher BAI (34.6 ± 33 vs 30.5 ± 7, p=0.04), but significantly lower IAT/BMI (2.35 ± 0.7 vs 2.51 ± 0.7, p<0.05) with no differences in other clinical (BMI, BF%, WC) and ultrasound (PreFT/BMI, EFT/BMI, PFT/BMI) indexes. The LDL-C goal achievement revealed inverse association with IAT/BMI (r=-0.15, p<0.05) and no associations with PreFT/BMI, EFT/BMI or PFT/BMI. Multivariable regression analysis revealed independent association between IAT/BMI and the LDL-C goal achievement. Conclusions: Intraabdominal fat thickness representing visceral adipose tissue is inversely associated with the LDL-C goal attainment independently from general obesity. It may help to identify individuals requiring more aggressive management of dylipidaemia.

Published
2015
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81. Rapid Fire Abstract session: multimodality imaging of ischaemic heart disease

Author

Faber, L, Lindner, O, Bogunovic, N, Hering, D, Burchert, W, Horstkotte, D, Nel, K T, Senior, R, Anstey, CM, Begley, J, Byrne, CD, Kaski, J, Bull, R, Boos, CJ, Greaves, K, Trifunovic, D, Stankovic, S, Stepanovic, J, Orlic, D, Banovic, M, Tesic, M, Petrovic, O, Petrovic, M, Djordjevic-Dikic, A, Vujisic-Tesic, B, Rodero, S, Mutuberria, M, Rodriguez-Palomares, J, Terricabras, M, Gutierrez, L, Teixido, G, Galian, L, Gonzalez-Alujas, T, Evangelista, A, Garcia-Dorado, D, Rodero, S, Mutuberria, M, Rodriguez-Palomares, J, Terricabras, M, Gutierrez, L, Teixido, G, Galian, L, Gonzalez-Alujas, T, Evangelista, A, Garcia-Dorado, D, Hammache, N, Voilliot, D, Brembilla-Perrot, B, Odille, F, Felblinger, J, Mandry, D, Marie, PY, Sadoul, N, Huttin, O, De Chillou, C, Olsen, F J, Jensen, JS, Pedersen, SH, Nochioka, K, and Biering-Sorensen, T

Abstract

Purpose: Low-intensity shock wave (SW) therapy (SWT) has been shown to improve symptoms and exercise tolerance in patients (pts.) with coronary artery disease (CAD). Methods47 pts. with severe stable angina in advanced CAD (mean age 67 ± 10 years) not suitable for surgical or catheter-based revascularization underwent a series of 9 echocardiography-targeted SW applications (3 applications/week in week 1, 5, and 9). The antero-septal wall (LAD territory) was targeted in 20, the lateral wall (RCX territory) in 20, and the inferior wall (RCA territory) in 7 pts. A series of 300-500 shocks was applied per session. Anti-anginal drugs therapy was kept unchanged. Regional myocardial blood flow (MBF) to the targeted region was measured by NH3-PET, and longitudinal regional strain was assessed by speckle tracking echocardiography at baseline and 4-6 weeks after SWT. Results: Complications of SWT did not occur. At follow-up, 34 pts. (72%) reported improvement of angina to a tolerable level. CCS angina class decreased from 3.1 ± 0.6 to 2.5 ± 0.6 (p<0.001). MBF in the target region improved from 117 ± 41 mL/min/100g to 128 ± 46 mL/min/100g (p=0.037), while there was no change in the opposite wall not treated with SWT (135 ± 51 vs. 136 ± 51 ml/min/100g; p=0.9). Longitudinal strain of the midventricular segment in the region targeted by SWT improved from -14 ± 5 to -17 ± 6 %; p=0.04. Conclusions: SWT improved symptoms in a sizeable number of pts. with chronic refractory angina. Regional MBF improvement in the region targeted by SWT was documented by PET imaging, and functional improvement by speckle tracking echocardiography. Additional studies are warranted to clarify the role of SWT in the armamentarium for this challenging patient group.

Published
2015
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82. Poster session 4: Friday 5 December 2014, 08:30-12:30 * Location: Poster area

Author

Orii, M, Tanimoto, T, Yokoyama, M, Ota, S, Kubo, T, Hirata, K, Tanaka, A, Imanishi, T, Akasaka, T, Michelsen, MM, Pena, A, Mygind, ND, Hoest, NB, Prescott, E, Abd El Dayem, SOHA, Battah, AHMED, Abd El Azzez, FATEN, Ahmed, AZZA, Fattoh, AYA, Ismail, REEM, Andjelkovic, K, Kalimanovska Ostric, D, Nedeljkovic, I, Andjelkovic, I, Rashid, HESHAM, Abuel Enien, HESHAM, Ibraheem, MAHER, work, Tissue Doppler echocardiography research, Vago, H, Toth, A, Csecs, I, Czimbalmos, CS, Suhai, F I, Kecskes, K, Becker, D, Simor, T, Merkely, B, D'ascenzi, F, Pelliccia, A, Natali, BM, Cameli, M, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Zaha, VG, Kim, GE, Su, KN, Zhang, J, Mikush, N, Ross, J, Palmeri, M, Young, LH, Tadic, M, Ilic, SI, Celic, VC, Jaimes, C, Gonzalez Mirelis, J, Gallego, M, Goirigolzarri, J, Pellegrinet, M, Poli, S, Prati, G, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Mateescu, A, Popescu, BA, Antonini-Canterin, F, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hewing, B, Theres, L, Dreger, H, Spethmann, S, Stangl, K, Baumann, G, Knebel, F, Uejima, T, Itatani, K, Nakatani, S, Lancellotti, P, Seo, Y, Zamorano, JL, Ohte, N, Takenaka, K, group, VFM international collaboration, Naar, J, Mortensen, L, Johnson, J, Winter, R, Shahgaldi, K, Manouras, A, Braunschweig, F, Stahlberg, M, Coisne, D, Al Arnaout, A-M, Tchepkou, C, Raud Raynier, P, Diakov, C, Degand, B, Christiaens, L, Barbier, P, Mirea, O, Cefalu, C, Savioli, G, Guglielmo, M, Maltagliati, A, O'neill, L, Walsh, K, Hogan, J, Manzoor, T, Ahern, B, Owens, P, Savioli, G, Guglielmo, M, Mirea, O, Cefalu, C, Barbier, P, Sengelov, M, Biering-Sorensen, T, Jorgensen, PG, Bruun, NE, Fritz-Hansen, T, Bech, J, Olsen, FJ, Sivertsen, J, Jensen, JS, Marta, L, Abecasis, J, Reis, C, Ribeiras, R, Andrade, MJ, Mendes, M, D'andrea, A, Stanziola, A, Di Palma, E, Martino, M, Lanza, M, Betancourt, V, Maglione, M, Calabro', R, Russo, MG, Bossone, E, Vogt, M O, Meierhofer, CH, Rutz, TH, Fratz, S, Ewert, P, Roehlig, CH, Kuehn, A, Storsten, P, Eriksen, M, Remme, EW, Boe, E, Smiseth, OA, Skulstad, H, Ereminiene, E, Ordiene, R, Ivanauskas, V, Vaskelyte, J, Stoskute, N, Kazakauskaite, E, Benetis, R, Marketou, M, Parthenakis, F, Kontaraki, J, Zacharis, E, Maragkoudakis, S, Logakis, J, Roufas, K, Vougia, D, Vardas, P, Dado, E, Dado, E, Knuti, G, Djamandi, J, Shota, E, Sharka, I, Saka, J, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Kurnicka, K, Domienik-Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska-Diduch, O, Ciurzynski, M, Pruszczyk, P, Chung, H, Kim, JY, Yoon, YW, Min, PK, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Choi, EY, Soya, OV, Kuryata, OV, Kakihara, R, Naruse, C, Inayoshi, A, El Sebaie, MAHA, Frer, ABDEL, Abdelsamie, MAGDY, Eldamanhory, AHMED, Ciampi, Q, Cortigiani, L, Simioniuc, A, Manicardi, C, Villari, B, Picano, E, Sicari, R, Ferferieva, V, Deluyker, D, Lambrichts, I, Rigo, JM, Bito, V, Kuznetsov, VA, Yaroslavskaya, EI, Krinochkin, DV, Pushkarev, GS, Gorbatenko, EA, Trzcinski, P, Michalski, BW, Lipiec, P, Szymczyk, E, Peczek, L, Nawrot, B, Chrzanowski, L, Kasprzak, JD, Todaro, MC, Zito, C, Khandheria, BK, Cusma-Piccione, M, La Carrubba, S, Antonini-Canterin, F, Di Bello, V, Oreto, G, Di Bella, G, Carerj, S, Gunyeli, E, Oliveira Da Silva, C, Sahlen, A, Manouras, A, Winter, R, Shahgaldi, K, Spampinato, RA, Tasca, M, Roche E Silva, JG, Strotdrees, E, Schloma, V, Dmitrieva, Y, Dobrovie, M, Borger, MA, Mohr, FW, Einarsen, E, Cramariuc, D, Lonnebakken, MT, Boman, K, Gohlke-Barwolf, C, Chambers, JB, Gerdts, E, Calin, A, Rosca, M, Beladan, CC, Mirescu Craciun, A, Gurzun, MM, Mateescu, A, Enache, R, Ginghina, C, Popescu, BA, Antova, E, Georgievska Ismail, LJ, Srbinovska, E, Andova, V, Peovska, I, Davceva, J, Otljanska, M, Vavulkis, M, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Dan, M, Yashima, F, Inohara, T, Maekawa, Y, Hayashida, K, Fukuda, K, Migliore, R, Adaniya, ME, Barranco, MA, Miramont, G, Gonzalez, S, Tamagusuku, H, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Amano, M, Izumi, C, Miyake, M, Tamura, T, Kondo, H, Kaitani, K, Nakagawa, Y, Ghulam Ali, S, Fusini, L, Tamborini, G, Muratori, M, Gripari, P, Bottari, V, Celeste, F, Cefalu', C, Alamanni, F, Pepi, M, Obase, K, Mor-Avi, V, Weinert, L, Lang, R, Teixeira, R, Monteiro, R, Garcia, J, Ribeiro, M, Cardim, N, Goncalves, L, Miglioranza, MH, Muraru, D, Cavalli, G, Addetia, K, Cucchini, U, Mihaila, S, Tadic, M, Veronesi, F, Lang, RM, Badano, L, Galian Gay, L, Gonzalez Alujas, MT, Teixido Tura, G, Gutierrez Garcia, L, Rodriguez-Palomares, JF, Evangelista Masip, A, Conte, L, Fabiani, I, Giannini, C, La Carruba, S, De Carlo, M, Barletta, V, Petronio, AS, Di Bello, V, Mahmoud, H, Al-Ghamdi, M, Ghabashi, A, Salaun, E, Zenses, AS, Evin, M, Collart, F, Pibarot, P, Habib, G, Rieu, R, Fabregat Andres, O, Estornell Erill, J, Cubillos-Arango, A, Bochard-Villanueva, B, Chacon-Hernandez, N, Higueras-Ortega, L, Perez-Bosca, L, Paya-Serrano, R, Ridocci-Soriano, F, Cortijo-Gimeno, J, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Mrabet, K, Kamoun, S, Fennira, S, Ben Chaabene, A, Kraiem, S, Schnell, F, Betancur, J, Daudin, M, Simon, A, Lentz, PA, Tavard, F, Hernandes, A, Carre, F, Garreau, M, Donal, E, Abduch, MCD, Vieira, MLC, Antunes, M, Mathias, W, Mady, C, Arteaga, E, Alencar, AM, Tesic, M, Djordjevic-Dikic, A, Beleslin, B, Giga, V, Trifunovic, D, Petrovic, O, Jovanovic, I, Petrovic, M, Stepanovic, J, Vujisic-Tesic, B, Choi, EY, Cha, JJ, Chung, H, Kim, KH, Yoon, YW, Kim, JY, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Bergler-Klein, J, Geier, C, Maurer, G, Gyongyosi, M, Cortes Garcia, M, Oliva, MR, Navas, MA, Orejas, M, Rabago, R, Martinez, ME, Briongos, S, Romero, AM, Rey, M, Farre, J, Ruisanchez Villar, C, Ruiz Guerrero, L, Rubio Ruiz, S, Lerena Saenz, P, Gonzalez Vilchez, FJ, Hernandez Hernandez, JL, Armesto Alonso, S, Blanco Alonso, R, Martin Duran, R, Gonzalez-Gay, MA, Novo, G, Marturana, I, Bonomo, V, Arvigo, L, Evola, V, Karfakis, G, Lo Presti, M, Verga, S, Novo, S, Petroni, R, Acitelli, A, Bencivenga, S, Cicconetti, M, Di Mauro, M, Petroni, A, Romano, S, Penco, M, Park, SM, Kim, SA, Kim, MN, Shim, WJ, Tadic, M, Majstorovic, AM, Ivanovic, BI, Celic, VC, Driessen, M M P, Meijboom, FJ, Mertens, L, Dragulescu, A, Friedberg, MK, De Stefano, F, Santoro, C, Buonauro, A, Muscariello, R, Lo Iudice, F, Ierano, P, Esposito, R, Galderisi, M, Sunbul, M, Kivrak, T, Durmus, E, Yildizeli, B, Mutlu, B, Rodrigues, AC, Daminello, E, Echenique, LS, Cordovil, A, Oliveira, W, Monaco, CH, Lira, E, Fischer, CH, Vieira, M, Morhy, S, Mignot, A, Jaussaud, J, Chevalier, L, Lafitte, S, D'ascenzi, F, Cameli, M, Curci, V, Alvino, F, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Ikonomidis, I, Pavlidis, G, Lambadiari, V, Kousathana, F, Triantafyllidi, H, Varoudi, M, Dimitriadis, G, Lekakis, J, Cho, J S, Cho, EJ, Yoon, HJ, Ihm, SH, Lee, JH, Molnar, A A, Kovacs, A, Apor, A, Tarnoki, AD, Tarnoki, DL, Horvath, T, Maurovich-Horvat, P, Jermendy, GY, Kiss, RG, Merkely, B, Al-Habbaa, A, Petrovic-Nagorni, S, Ciric-Zdravkovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Atanaskovic, V, Mitic, V, Todorovic, L, Dakic, S, Park, J S, Choi, JH, Kim, SH, Choi, JH, Kwon, YS, Jin, HY, Coppola, C, Piscopo, G, Galletta, F, Maurea, C, Esposito, E, Barbieri, A, Maurea, N, Kaldararova, M, Tittel, P, Kantorova, A, Vrsanska, V, Kollarova, E, Hraska, V, Nosal, M, Ondriska, M, Masura, J, Simkova, I, Tadeu, I, Azevedo, O, Lourenco, M, Luis, F, Lourenco, A, Planinc, i, Bagadur, G, Bijnens, B, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Milicic, D, Cikes, M, Campanale, C M, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, El Tahlawi, M, Abdallah, M, Gouda, M, Gad, MARWA, Elawady, M, Igual Munoz, B, Maceira Gonzalez Alicia, AMG, Estornell Erill, JEE, Donate Betolin, LDB, Vazquez Sanchez Alejandro, AVS, Valera Martinez, FVM, Sepulveda- Sanchez, PSS, Cervera Zamora, ACZ, Piquer Gil Marina, MPG, Montero- Argudo, AMA, Naka, KK, Evangelou, D, Lakkas, L, Kalaitzidis, R, Bechlioulis, A, Gkirdis, I, Tzeltzes, G, Nakas, G, Pappas, K, Michalis, LK, Mansencal, N, Bagate, F, Arslan, M, Siam-Tsieu, V, Deblaise, J, El Mahmoud, R, Dubourg, O, Wierzbowska-Drabik, K, Plewka, M, Kasprzak, JD, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Bandera, F, Generati, G, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Grycewicz, T, Szymanska, K, Grabowicz, W, Lubinski, A, Sotaquira, M, Pepi, M, Tamborini, G, Caiani, EG, Bochard Villanueva, B, Chacon-Hernandez, N, Fabregat-Andres, O, Garcia-Gonzalez, P, Cubillos-Arango, A, De La Espriella-Juan, R, Albiach-Montanana, C, Berenguer-Jofresa, A, Perez-Bosca, JL, Paya-Serrano, R, Cheng, H-L, Huang, C-H, Wang, Y-C, Chou, W-H, Kuznetsov, VA, Melnikov, NN, Krinochkin, DV, Kolunin, GV, Enina, TN, Sierraalta, W, Le Bihan, D, Barretto, RBM, Assef, JE, Gospos, M, Buffon, M, Ramos, AIO, Garcia, A, Pinto, IMF, Souza, AGMR, Mueller, H, Reverdin, S, Ehret, G, Conti, L, Dos Santos, S, Abdel Moneim, S S, Nhola, L F, Huang, R, Kohli, M, Longenbach, S, Green, M, Villarraga, H R, Bordun, K A, Jassal, D S, Mulvagh, S L, Evangelista, A, Madeo, A, Piras, P, Giordano, F, Giura, G, Teresi, L, Gabriele, S, Re, F, Puddu, P, Torromeo, C, Suwannaphong, S, Vathesatogkit, P, See, O, Yamwong, S, Katekao, W, Sritara, P, Iliuta, L, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Weng, K-P, Lin, C-C, Hein, S, Lehmann, L, Kossack, M, Juergensen, L, Katus, HA, Hassel, D, Turrini, F, Scarlini, S, Giovanardi, P, Messora, R, Mannucci, C, Bondi, M, Olander, R, Sundholm, JKM, Ojala, TH, Andersson, S, Sarkola, T, Karolyi, M, Kocsmar, I, Raaijmakers, R, Kitslaar, PH, Horvath, T, Szilveszter, B, Merkely, B, Maurovich-Horvat, P, Heart, Center, Vascular, University, Semmelweis, Budapest, Hungary, and Group, MTA-SE Lendület Cardiovascular Imaging Research

Abstract

Purpose: Although delayed-enhancement magnetic resonance imaging (DEMRI) is essential for diagnosis of cardiac sarcoidosis (CS), the test was not available when pacemaker was implamted. Recently, MR-conditional pacemaker has become avilable and we hypothesized that this device would be useful for diagnosis and management of CS. The aim of this study was to assess the diagnostic ability of MR-conditional pacemaker about CS in patients with advanced A-V nodal block (AAVB). Methods: Twenty-seven AAVB patients (14 men, 13 women; mean age, 69 ± 11 years) who were implanted MR-conditional pacemaker were studied. DEMRI was performed 6 weeks after implantation of permanent pacemaker. In patients with positive for DE, additional examinations like echocardiography, radioisotope imaging, biopsy, and coronary computed-tomography were performed due to confirm the diagnosis of CS and exclude coronary artery disease. Results: DE was observed in 12 patients (44 %). Out of 12 patients, 2 patients were excluded for having prior myocardial infarction. Seven of 10 (70 %) patients were diagnosed of CS by the consensus criteria. Compared with non-CS group, CS group had significantly lower age (61 ± 12 years vs. 72 ± 9 years p = 0.017). There was no significant difference about sex, angiotensin-converting enzyme, brain natriuretic peptide, and left ventricular ejection fraction between 2 groups. Six patients had started corticosteroid therapy and 5 patients (83%) recovered A-V nodal conduction. Conclusion: MR-conditional pacemaker was useful for diagnosis and management of patients with AAVB caused by CS. Figure Cardiac MRI in patient with AV block

Published
2014
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83. Oral Abstract session: Different imaging modalities for the approach of coronary artery disease: Friday 5 December 2014, 16:30-18:00 * Location: Agora

Author

Jovanovic, I, Tesic, M, Giga, V, Petrovic, O, Petrovic, MT, Stepanovic, J, Trifunovic, D, Vujisic-Tesic, B, Beleslin, B, Djordjevic-Dikic, A, Petersen, S E, Genders, TSS, Pugliese, F, Dastidar, AG, Fleischmann, KE, Nieman, K, Hunink, MGM, Cameli, M, Lisi, M, Righini, FM, Sparla, S, Di Tommaso, C, Lunghetti, S, Galderisi, M, Mondillo, S, Djordjevic-Dikic, A, Boskovic, N, Tesic, M, Paunovic, I, Giga, V, Stepanovic, J, Kostic, J, Dobric, M, Trifunovic, D, Beleslin, B, Vilela, AA, Assef, JE, Barretto, RBM, Le Bihan, D, Melchior, W, Ramos, RF, Santos, ES, Souza, AGMR, Voilliot, D, Odille, FO, Mandry, DM, Huttin, OH, Andronache, MA, Marie, PYM, Felblinger, JF, Aliot, EA, Sadoul, NS, De Chillou, CDC, Liou, K, Ho, S, Cranney, G, Ooi, S, Carminati, MC, Boniotti, C, Pontone, G, Andreini, D, Pepi, M, and Caiani, EG

Abstract

Background: Slow coronary flow (SCF) is a well-known clinical phenomenon, characterized by delayed opacification of coronary arteries in the absence of coronary artery stenosis. It is hypothesized that impaired endothelial function reduces coronary flow velocity reserve (CFVR), and results in microvascular ischemia causing chest pain. Also, left ventricular (LV) global longitudinal systolic strain (GLS) can be affected in this setting. The aim of this study was to: 1) evaluate how LV-GLS and CFVR are affected in patients with positive exercise tests and coronary angiograms with or without SCF. 2) examine relations between CFVR and LV-GLS. Methods: Examined group consisted of 24 female pts (mean age 58±8 years) with ECG positive exercise tests and coronary angiograms without stenosis. TIMI Flow Grade (TFG) was used as a grading system for SCF, based on the rate of dye entry into the distal landmarks of the vessel bed. According to that, examined group was subdivided into: Group 1 (7 pts with SCF (TGF<3)) and Group 2 (17 pts with TGF 3). Twenty healthy control subjects (mean age 55±9 years) were also enrolled. GLS was obtained from the three standard apical views and off-line image analysis was performed using commercial software with speckle tracking methodology derived from 2D gray-scale images. Transthoracic Doppler echocardiography CFVR was performed in left anterior descending coronary (LAD) and right coronary artery (RCA) and calculated as the ratio between hyperemic maximal flow velocity (induced with i.v. infusion of adenosine 0.14mg/kg/min) and resting flow velocity. Results Examined group compared to the control group had significantly impaired LV-GLS (-17.5±2.2 vs. -21.9±2.5, p<0.001), CFVR LAD (2.60±0.56 vs. 3.34±0.67, p<0.001) and CFVR RCA (2.48±0.42 vs. 3.20±0.64, p<0.001). Group 1 in comparison to Group 2 had lower LV-GLS (-15.9±1.3 vs. -18.2±2.2, p=0.021), CFVR LAD (2.04±0.16 vs. 2.84±0.48, p<0.001) and CFVR RCA (2.08±0.19 vs. 2.65±0.38, p=0.001). In the examined group LV-GLS correlated both with CFVR LAD (r=-0.449, p=0.028) and CFVR RCA (r=-0.514, p=0.010). Conclusions: This study shows that blunted CFVR values in SCF setting are associated with depressed LV-GLS, demonstrating an important pathophysiological link between the impairment of microcirculation and longitudinal LV systolic function.

Published
2014
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93. The prognostic importance of right ventricular remodeling and the circadian blood pressure pattern on the long-term cardiovascular outcome

Author

Marijana Tadic, Giuseppe Mancia, Cesare Cuspidi, Branislava Ivanovic, Biljana Pencic, Olga Petrovic, Vera Celic, Guido Grassi, Tadic, M, Cuspidi, C, Celic, V, Petrovic, O, Pencic, B, Mancia, G, Grassi, G, and Ivanovic, B

Subjects
Adult, Male, Right atrial enlargement, medicine.medical_specialty, Ambulatory blood pressure, Physiology, Diastole, Blood Pressure, right ventricle, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Ventricular remodeling, blood pressure pattern, Aged, Ventricular Remodeling, business.industry, Atrial fibrillation, Middle Aged, medicine.disease, Prognosis, cardiovascular event, Circadian Rhythm, Blood pressure, Cardiovascular Diseases, Heart failure, Hypertension, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

OBJECTIVE We sought to investigate the predictive value of right ventricular (RV) remodeling and 24-h blood pressure (BP) patterns on long-term cardiovascular prognosis in the initially untreated hypertensive patients. METHODS The current study included 505 initially untreated hypertensive patients who were consequently included in this study from 2007 to 2012. All the patients underwent laboratory analysis, 24-h BP monitoring and echocardiographic examination at baseline. The patients were followed for a median period of 9 years. The adverse outcome was defined as the hospitalization due to cardiovascular events (atrial fibrillation, myocardial infarction, myocardial revascularization, heart failure, stroke, or cardiovascular death). RESULTS During the 9-year follow-up period adverse cardiovascular events occurred in 82 hypertensive patients. Night-time SBP, the nondipping BP pattern, left ventricle hypertrophy, RV hypertrophy, right atrial enlargement, RV diastolic dysfunction, and RV systolic dysfunction were associated with adverse cardiovascular events. Nevertheless, night-time SBP, the nondipping BP pattern, mitral E/e', left ventricle hypertrophy, and RV hypertrophy were the only independent predictors of cardiovascular events. When all four BP patterns were included in the model, only the reverse dipping BP pattern was an independent predictor of cardiovascular events. CONCLUSION The present investigation showed that RV hypertrophy and the reverse dipping BP pattern were independent long-term predictors of the cardiovascular outcome. Detailed echocardiographic evaluation and 24-h ambulatory blood pressure monitoring should be performed even in low-risk hypertensive patients.

Published
2020

94. Does Atrial Fibrillation at Diagnosis Change Prognosis in Patients with Aortic Stenosis?

Author

Petrovic O, Vidanovic S, Jovanovic I, Paunovic I, Rakocevic I, Milasinovic D, Tesic M, Boskovic N, Dukic D, Ostojic M, Vratonjic J, Mladenovic A, and Trifunovic-Zamaklar D

Abstract

Background: Aortic stenosis (AS) is a common valve disease and atrial fibrillation (AF) is the most common cardiac arrhythmia, frequently associated with AS. This study aimed to evaluate the impact of AF on mortality in patients with moderate and severe AS. Methods: We retrospectively analyzed 1070 consecutive moderate and severe AS patients (57% were male, age was 69 ± 10, severe AS 22.5%), who underwent transthoracic echocardiography from March 2018 to November 2021. AS severity was defined by specific threshold values with severe AS being defined by a peak velocity > 4 m/s, an MPG > 40 mmHg, and an AVA < 1 cm 2 and moderated by a peak velocity of 3-4 m/s, an MPG 20-40 mmHg and an AVA 1-1.5 cm. Patients with AF were defined as those having a history of AF when AS was found on the index echocardiography. The follow-up assessment in December 2023 ascertained vital status and data on aortic valve replacement (AVR). Results: 790 (73.8%) patients were with sinus rhythm (SR) and 280 (26.2%) patients with AF. Mortality was higher in patients with AF than in those with SR (46% vs. 36.2% HR 1.424, 95% CI 1.121-1.809, p = 0.004). After adjusting for clinical confounders, mortality risk in AF relative to SR remained significant (HR 1.284, 95% CI 1.03-1.643, p = 0.047). Patients with AF demonstrated high mortality risk in the moderate aortic stenosis stratum (HR 1.376, 95% CI 1.059-1.788, p = 0.017), with even greater risk in the severe AS stratum (HR 1.644, 95% CI 1.038-2.603, p = 0.034) with significant interaction ( p = 0.007). In patients with AF AVR demonstrated a protective effect on survival (HR 0.365, 95% CI 0.202-0.627, p < 0.001), but to a lesser degree than in patients with sinus rhythm (HR 0.376, 95% CI 0.250-0.561, p < 0.001) without significant interaction ( p = 0.278). In patients with AF mortality risk was high in the conservative treatment stratum (HR 1.361, 95% CI 1.066-1.739, p = 0.014), in the AVR stratum mortality risk was higher but did not reach statistical significance (HR 1.823, 95% CI 0.973-3.414, p = 0.061). However, when corrected for echocardiographic variables strongly correlated with AF, AF was no longer independently associated with all-cause mortality. (HR 0.97 95% CI 0.709-1.323, p = 0.84). Conclusions: Patients with moderate and severe AS and AF have worse prognosis than patients with SR which can be explained by cardiac damage. AVR improves survival in patients with AF and with SR.

Published
2024
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95. Imaging in Infective Endocarditis-Current Opinions and Trends in Cardiac Computed Tomography.

Author

Petkovic A, Menkovic N, Petrovic O, Bilbija I, Nisevic M, Radovanovic NN, Stanisavljevic D, Putnik S, Maksimovic R, and Ivanovic B

Abstract

Infective endocarditis is a rare disease with an increasing incidence and an unaltered high mortality rate, despite medical development. Imaging plays an integrative part in the diagnosis of infective endocarditis, with echocardiography as the initial diagnostic test. Research data in the utility of cardiac computed tomography (CCT) in the diagnostic algorithm of IE are rising, which indicates its importance in detection of IE-related lesion along with the exclusion of coronary artery disease. The latest 2023 European Society of Cardiology Guidelines in the management of IE classified CCT as class of recommendation I and level of evidence B in detection of both valvular and paravalvular lesions in native and prosthetic valve endocarditis. This review article provides a comprehensive and contemporary review of the role of CCT in the diagnosis of IE, the optimization of acquisition protocols, the morphology characteristics of IE-related lesions, the published data of the diagnostic performance of CCT in comparison to echocardiography as the state-of-art method, as well as the limitations and future possibilities.

Published
2024
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96. Correlation of Non-Invasive Transthoracic Doppler Echocardiography with Invasive Doppler Wire-Derived Coronary Flow Reserve and Their Impact on Infarct Size in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention.

Author

Milasinovic D, Tesic M, Nedeljkovic Arsenovic O, Maksimovic R, Sobic Saranovic D, Jelic D, Zivkovic M, Dedovic V, Juricic S, Mehmedbegovic Z, Petrovic O, Trifunovic Zamaklar D, Djordjevic Dikic A, Giga V, Boskovic N, Klaric M, Zaharijev S, Travica L, Dukic D, Mladenovic D, Asanin M, and Stankovic G

Abstract

Background : Coronary microvascular dysfunction is associated with adverse prognosis after ST-segment elevation myocardial infarction (STEMI). We aimed to compare the invasive, Doppler wire-based coronary flow reserve (CFR) with the non-invasive transthoracic Doppler echocardiography (TTDE)-derived CFR, and their ability to predict infarct size. Methods : We included 36 patients with invasive Doppler wire assessment on days 3-7 after STEMI treated with primary percutaneous coronary intervention (PCI), of which TTDE-derived CFR was measured in 47 vessels (29 patients) within 6 h of the invasive Doppler. Infarct size was assessed by cardiac magnetic resonance at a median of 8 months. Results : The correlation between invasive and non-invasive CFR was modest in the overall cohort (rho 0.400, p = 0.005). It improved when only measurements in the LAD artery were considered (rho 0.554, p = 0.002), with no significant correlation in the RCA artery (rho -0.190, p = 0.435). Both invasive (AUC 0.888) and non-invasive (AUC 0.868) CFR, measured in the recanalized culprit artery, showed a good ability to predict infarct sizes ≥18% of the left ventricular mass, with the optimal cut off values of 1.85 and 1.80, respectively. Conclusions : In patients with STEMI, TTDE- and Doppler wire-derived CFR exhibit significant correlation, when measured in the LAD artery, and both have a similarly strong association with the final infarct size.

Published
2024
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97. Late presentation of traumatic tricuspid valve chordal rupture and pericardial rupture with cardiac herniation: a case report.

Author

Radovanovic N, Prodanovic M, Radosavljevic-Radovanovic M, Bilbija I, Petrovic O, Lojovic N, Kecman E, Djekic A, Radovanovic M, and Matic D

Subjects
Male, Humans, Middle Aged, Tricuspid Valve diagnostic imaging, Tricuspid Valve surgery, Echocardiography adverse effects, Pericardium diagnostic imaging, Pericardium surgery, Rupture complications, Wounds, Nonpenetrating complications, Wounds, Nonpenetrating diagnostic imaging, Wounds, Nonpenetrating surgery, Tricuspid Valve Insufficiency diagnostic imaging, Tricuspid Valve Insufficiency etiology, Tricuspid Valve Insufficiency surgery, Thoracic Injuries diagnosis, Heart Injuries complications, Heart Injuries diagnostic imaging
Abstract

Background: Although chest trauma happens very often, accompanying tricuspid valve injuries occur rarely and may be manifested by scarce symptoms and signs. Pericardial rupture with cardiac herniation is even a bigger rarity. Transthoracic echocardiography plays a key role in the diagnosis of valve injuries but is of limited value in cardiac herniation., Case Presentation: We present the case of 58-year-old man who experienced severe chest trauma in a car accident. Symptoms of right heart failure occurred 10 years after the injury, due to the loss of tricuspid leaflet support caused by the rupture of tendinous chords with significant tricuspid regurgitation. Intraoperatively, old posttraumatic pericardial rupture into left pleura was also found, with partial cardiac herniation and pressure of the edge of pericardium on all left-sided coronary arteries simultaneously. The patient was successfully operated and is free of symptoms 4 years later., Conclusions: This case emphasizes the importance of timely diagnosis and underlines a mechanism that leads to delayed rupture of the tricuspid valve apparatus. Repeated echocardiography in all patients who experienced chest trauma could be of great importance. Also, given the limited value of echocardiography in posttraumatic pericardial rupture and cardiac herniation, cardiac computed tomography should be performed., (© 2024. The Author(s).)

Published
2024
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98. The Role of Echocardiography and Cardiac Computed Tomography in Diagnosis of Infective Endocarditis.

Author

Petkovic A, Menkovic N, Petrovic O, Bilbija I, Radovanovic NN, Stanisavljevic D, Putnik S, Maksimovic R, and Ivanovic B

Abstract

Background: Infective endocarditis (IE) is a rare disease with a high mortality rate and rising incidence, requiring timely and precise diagnosis in order to choose appropriate therapy. Imaging of morphologic lesions is an integrative part of diagnosis. Artifacts and the patient's habitus make echocardiography difficult to visualize advanced-form IE. Cardiac computed tomography (CCT) constantly shows an additive diagnostic value due to high resolution of cardiac anatomy. Conjecturally, joint application of both diagnostic tests improves overall sensitivity and specificity in diagnosing IE., Methods: Patients with definite IE underwent transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and CCT. We analyzed valvular and paravalvular IE lesions in all three imaging methods and compared them to surgical or autopsy findings. We calculated sensitivity, specificity, diagnostic accuracy, and positive and negative predictive value of both imaging tests individually and jointly used., Results: We examined 78 patients, male to female ratio 2:1, mean age 52.29 ± 16.62. We analyzed 85 valves, 70 native valves, 13 prosthetic valves, and 2 corrected valves due to Ozaki procedure, along with a central shunt and 4 pacemaker leads. As a single test, the sensitivity and specificity of CCT, TTE, and TEE for valvular lesions were 91.6/20%, 65.5/57.9%, and 60/84%, and paravalvular lesions were 100/0%, 46/10.5%, and 14.7/100%. When combined together, sensitivity and specificity for valvular lesions rose to 96.6/0% and paravalvular lesions to 100/0%. We also analyzed the diagnostic performance for each test in single and mutual application, per specific IE lesion., Conclusion: In the individual application, CCT in comparison to TTE and TEE shows better diagnostic performance in detection of valvular and paravalvular lesions. In joint application, there is a statistically significant difference in performance compared to their single use, especially in prosthetic valves and invasive forms of IE native valves.

Published
2023
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99. The Potential of Liquid Biopsy in Detection of Endometrial Cancer Biomarkers: A Pilot Study.

Author

Kodada D, Hyblova M, Krumpolec P, Janostiakova N, Barath P, Grendar M, Blandova G, Petrovic O, Janega P, Repiska V, and Minarik G

Subjects
Humans, Female, Biomarkers, Tumor genetics, Pilot Projects, Reproducibility of Results, Mutation, Liquid Biopsy methods, Circulating Tumor DNA genetics, Endometrial Neoplasms diagnosis, Endometrial Neoplasms genetics
Abstract

Endometrial cancer belongs to the most common gynecologic cancer types globally, with increasing incidence. There are numerous ways of classifying different cases. The most recent decade has brought advances in molecular classification, which show more accurate prognostic factors and the possibility of personalised adjuvant treatment. In addition, diagnostic approaches lag behind these advances, with methods causing patients discomfort while lacking the reproducibility of tissue sampling for biopsy. Minimally invasive liquid biopsies could therefore represent an alternative screening and diagnostic approach in patients with endometrial cancer. The method could potentially detect molecular changes in this cancer type and identify patients at early stages. In this pilot study, we tested such a detection method based on circulating tumour DNA isolated from the peripheral blood plasma of 21 Slovak endometrial cancer patients. We successfully detected oncomutations in the circulating DNA of every single patient, although the prognostic value of the detected mutations failed to offer certainty. Furthermore, we detected changes associated with clonal hematopoiesis, including DNMT3A mutations, which were present in the majority of circulating tumour DNA samples.

Published
2023
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100. Psychometric properties of the Cystic Fibrosis Eating Attitudes and Behaviours scale (CFEAB) in an adult population.

Author

Mc Hugh R, Vaughan RS, Duarte C, McDevitt-Petrovic O, and Kirby K

Subjects
Humans, Adult, Psychometrics, Cross-Sectional Studies, Attitude, Anxiety, Surveys and Questionnaires, Reproducibility of Results, Cystic Fibrosis psychology
Abstract

Objectives: Individuals with Cystic Fibrosis (CF) may be at an increased risk of developing a range of eating difficulties. Scales designed to measure disordered eating in the general population do not cover CF-specific behaviours resulting in a knowledge gap. The CFEAB was developed as a CF-specific measure assessing eating behaviours and attitudes however little evidence exists regarding its psychometric quality. The aim of this cross-sectional study was to provide a robust assessment of its internal consistency, structural validity, and criterion validity., Methods: One-hundred and thirty-two people with CF completed self-report scales pertaining to mental health, eating disorders, and the Cystic Fibrosis Eating Attitudes and Behaviours (CFEAB)., Results: Results of exploratory structural equation modelling indicated that a three-factor structure produced good fit with the 24-item CFEAB but a purified 12-item CFEAB displayed superior fit and internal consistency. Also, the 12-item scale predicted significant amounts of variance for anxiety, depression, and eating disorders showing enhanced relevance for clinical use. Conclusions These findings add emphasis to the importance of the validation and development of CF-specific measures and the possible inclusion at clinics to help improve CF patient care., (Crown Copyright © 2022. Published by Elsevier Inc. All rights reserved.)

Published
2023
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