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This study explores the context of identity in the musical arts echoed by a Black Metal band from Kediri, Immortal Rites. Aesthetically, Immortal Rites articulate Javanese locality using Black Metal, a sub-genre of underground music that emerged in Indonesia in the late 90s. Accordingly, the band lined up as one of the Kejawen Black Metal whose consistency and depth of understanding are well appreciated within the scene. The unification of two different cultures provokes a complex contemporary value of a cultural reflection concerning identity. This study uses a qualitative research method with a descriptive approach. This study aims to discuss the narrative of identity that Immortal Rites wish to embody for its fans to understand. By focusing analysis on the main data of song lyrics with additional data in the form of interviews, we found that the echoed locality represents a notion of contemporary Javanese identity. Within the arts, there was a close relevance of the content with the identical Javaneseness in the era of the Kadiri kingdom. Thus, based on the engagement of the arts and the Kediri-based Javaneseness, it leads us to an understanding of the mediated cultural representation of contemporary Javanese identity, of a Daha-based Javanese identity.

Compelling evidence has clearly linked the metabolism of arachidonic acid (AA) to intestinal tumorigenesis. Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of cyclooxygenase (COX)-1 COX-2 or both, are effective chemopreventive agents in the prevention of intestinal tumors and in the regression of preexisting tumors in humans and animal models. Because NSAIDs inhibit the committed step in prostaglandin biosynthesis, some researchers have suggested that unmetabolized free AA levels induce ceramide-mediated apoptosis whereas others attribute the antitumorigenic effects of NSAIDs to reductions in prostaglandins, in particularly prostaglandin (PC) [E.sub.2]. This study set out to establish, with a greater degree of certainty, that the AA cascade was important in intestinal tumorigenesis by using [Apc.sub.Min/+] mice. Elevating intracellular concentrations of AA in tumors of [Apc.sub.Min/+] mice above basal levels had no effect on tumor load in the presence or absence of NSAIDs. However, reducing tissue AA content (with n-3 fatty acids) was correlated with a reduction in tumor number, and these effects were reversed in add-back experiments using dietary AA. Furthermore, inhibition of de novo biosynthesis of AA by using SC26196, a selective inhibitor of [DELTA]-6 desaturase, repeatedly reduced tumor number by 35-40%, and by-passing this inhibition with concomitant treatment of dietary AA rescued the tumors. To establish whether these effects could be related to prostaglandins, we set out to regress preexisting tumors with the NSAIDs piroxicam and sulindac and rescue these tumors (in vivo) with stable analogues of PG[E.sub.2]. We established that piroxicam and sulindac could eliminate 80-95% of preexisting tumors within 6 d. Immunohistochemical analysis of the tumors demonstrated that COX-2 expression was localized in the stoma of the tumors and protein levels progressively declined with length of NSAID exposure. These changes were associated with decreases in [beta]-catenin, Bcl-2 and mitosis and increases in apoptosis in tumor epithelial cells. When EP receptor agonists (16,16-dimethyl-PG[E.sub.2] and 17-phenyl-trinor-PG[E.sub.2]) were provided to the NSAID-treated animals, tumor regression was significantly attenuated (rescuing the tumors) and the apoptosis-mitosis index normalized to control levels. In a follow-up study, we systemically sequestered PG[E.sub.2] after intraperitoneal administration of a monoclonal antibody against PG[E.sub.2]. This treatment reduced the number of preexisting tumors by 35% (P < 0.05) within 4 d. Collectively, these data demonstrate for the first time that AA is important in intestinal tumorigenesis in vivo but there appears to be a threshold for this effect, NSAIDs regress preexisting tumors in part by inhibiting PG biosynthesis and PG[E.sub.2] is important in maintaining intestinal tumor integrity in vivo. [Supported in part by grants from the American Institute for Cancer Research, Pharmacia Corporation and the Tennessee Agricultural Experiment Station.]

The project described in this paper is based on sequential and progressive approach to development of a temperature controlled weather condition emulator for testing of concrete samples during a short period of time. It can be used to test concrete samples when the engineer wants to investigate the concrete behaviour under extreme conditions such as cold, very high temperature or drastic drops of temperature incurred in a short period. As an initial phase of the development process, the entire system architecture is sub-phased to a modular form and hence formulates each module for simulation before realizing of the final fabrication of the actual system. The main objective here is to model the proposed concrete test equipment with an attached thermoelectric Peltier as the main heat source. Mathematical modelling of dynamics of the Peltier systems are not well defined and they are assumed to be highly nonlinear in behaviour. Therefore, controlling of the system is selected by a fuzzy inference engine. Modelling of the system dynamics is carried out by approximating the real behaviour of Peltier dynamics. Simulations of a subjective testing chamber with Peltier dynamics are carried out through a model based on the Matlab/Simulink integrated project, in which the characteristics of the proposed emulator are discussed and analysed with given appropriate constrains. Finally, the obtained simulation results are tested as per initial phase according to the expectations of the concrete test emulator requirements. [ABSTRACT FROM AUTHOR]

The method based on the density-functional theory has been used to study the solubility of 3 p (Al, Si) and 4 p (Ga, Ge) elements in ferromagnetic and paramagnetic states of bcc iron. To simulate the paramagnetic state, two different approaches have been employed, which were implemented using the SIESTA and LSGF packages. It has been established that the solution energy of all these impurities decreases upon the transition into the paramagnetic state. The solution energies obtained by averaging over the ensemble of unpolarized magnetic configurations agree well with the values obtained in the coherentpotential approximation. At the same time, the allowance for the magnetic polarization in the vicinity of an impurity leads to a decrease in the solution energy, which is most clearly pronounced at temperatures close to TC. The temperature dependence of the solution energies of the impurities in the paramagnetic state is discussed. [ABSTRACT FROM AUTHOR]

The complex formation of the bifunctional monophosphinic acid DOTA analogue DO3APABn (1,4,7,10-tetraazacyclododecane-4,7,10-triacetic-1-{methyl[(4-aminophenyl)methyl] phosphinic acid}) with 111In at a tracer level was analyzed. Formation of a complex between 111In and DO3APABn was very rapid even at room temperature and high radiolabeling yields were achieved. As introducing the methylphosphinic acid arm to the DOTA structure generated a chiral centre, more than one peak (probably corresponding to various diastereoisomers) of 111In-DO3APABn were separated on HPLC. Four peaks were separated by HPLC, they probably correspond to four diastereoisomers of 111In-DO3APABn originating from combination of chirality of complexes of DOTA-like ligands with chirality of coordinated phosphorus atom. Studies in rats showed rapid elimination of radioactivity from the blood and other organs and tissues. The results indicate that DO3APABn represents a promising ligand for radiolabeling of target-specific biomolecules with radiometals. [ABSTRACT FROM AUTHOR]

We showed previously that dietary eicosapentaenoic acid [EPA, 20:5(n-3)] is antitumorigenic in the APC:(Min/+) mouse, a genetic model of intestinal tumorigenesis. Only a few studies have evaluated the effects of dietary fatty acids, including EPA and docosahexaenoic acid [DHA, 22:6(n-3)], in this animal model and none have evaluated the previously touted antitumorigenicity of alpha-linolenic acid [ALA, 18:3(n-3)], conjugated linoleic acid [CLA, 77% 18:2(n-7)], or gamma-linolenic acid [GLA, 18:3(n-6)]. Stearidonic acid [SDA, 18:4(n-3)], the Delta6-desaturase product of ALA, which is readily metabolized to EPA, has not been evaluated previously for antitumorigenic efficacy. This study was undertaken to evaluate the antitumorigenicity of these dietary fatty acids (ALA, SDA, EPA, DHA, CLA and GLA) compared with oleic acid [OA, 18:1(n-9)] at a level of 3 g/100 g in the diets of APC:(Min/+) mice and to determine whether any alterations in tumorigenesis correspond to alterations in prostaglandin biosynthesis. Tumor multiplicity was significantly lower by approximately 50% in mice fed SDA or EPA compared with controls, whereas less pronounced effects were observed in mice fed DHA (P: = 0.15). ALA, CLA and GLA were ineffective at the dose tested. Although lower tumor numbers coincided with significantly lower prostaglandin levels in SDA- and EPA-fed mice, ALA and DHA supplementation resulted in equally low prostaglandin levels, despite proving less efficacious with regard to tumor number. Prostaglandin levels did not differ significantly in the CLA and GLA groups compared with controls. These results suggest that SDA and EPA attenuate tumorigenesis in this model and that this effect may be related in part to alterations in prostaglandin biosynthesis. [ABSTRACT FROM AUTHOR]

The multiple intestinal neoplasia (Apc(Min/+)) mouse possesses a germline mutation at codon 850 of the adenomatous polyposis coli (Apc) gene resulting in the formation of a nonfunctional truncated gene product. Following a somatic mutation of the remaining wild-type allele, mice spontaneously develop approximately 40-50 tumors throughout the intestinal tract. This mouse model has been used to study intestinal tumorigenesis because this mutation is analogous to the inherited APC mutation in humans with familial adenomatous polyposis (FAP). These individuals characteristically develop numerous adenomas throughout their intestinal tracts. Only a few studies have evaluated the effects of dietary fatty acids on tumorigenesis in this animal model with varying results, and none have linked these effects to alterations in arachidonic acid (AA) metabolism. This study was designed to evaluate the antitumorigenic effect of dietary (n-3) polyunsaturated fatty acids (PUFA) in the Apc(Min/+) mouse model and to determine whether these effects are related to inhibition of AA metabolism. Male Apc(Min/+)mice were fed diets supplemented with eicosapentaenoic acid (EPA), AA or a combination of AA + EPA. Mean tumor number in the EPA group was 68% lower (P<0.05) compared with the control group, whereas AA supplementation did not significantly alter tumor load. The reduction in tumor load coincided with significant reductions in intestinal AA content and levels of prostaglandins. However, supplementing AA to the EPA diet (AA + EPA) abolished the antitumorigenic effect of EPA, increased tissue AA content fourfold and prostaglandin production two- to fourfold. These results indicate that AA is involved in tumorigenesis and suggest that EPA's ability to reduce tumor load in Apc(Min/+) mice is related to reductions in tissue AA content or its metabolism. [ABSTRACT FROM AUTHOR]