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56. Real-time sensing of flowing nanoparticles with electro-opto-mechanics

Author

Suh, Jeewon, Han, Kewen, Peterson, Christopher W, and Bahl, Gaurav

Subjects
Physics - Optics
Abstract

High-Q optical resonators allow label-free detection of individual nanoparticles through perturbation of optical signatures but have practical limitations due to reliance on random diffusion to deliver particles to the sensing region. We have recently developed microfluidic optomechanical resonators that allow detection of free-flowing particles in fluid media with near perfect detection efficiency, without requiring labeling, binding, or direct access to the optical mode. Rapid detection of single particles is achieved through a long-range optomechanical interaction that influences the scattered light spectra from the resonator, which can be quantified with post-processing. Here, we present a hybrid electromechanical-optomechanical technique for substantially increasing the bandwidth of these optomechanofluidic sensors, enabling real-time operation. The presented system demonstrates temporal resolution of better than 20~\us (50,000 events/second) with particle sensing resolution down to 490 nm, operating in the air without any stabilization or environmental control. Our technique significantly enhances the sensing capabilities of high-Q optical resonators into the mechanics domain, and allows extremely high-throughput analysis of large nanoparticle populations., Comment: 11 pages, 5 figures

Published
2016

59. Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.

Author

Zhen, Anjie, Peterson, Christopher W, Carrillo, Mayra A, Reddy, Sowmya Somashekar, Youn, Cindy S, Lam, Brianna B, Chang, Nelson Y, Martin, Heather A, Rick, Jonathan W, Kim, Jennifer, Neel, Nick C, Rezek, Valerie K, Kamata, Masakazu, Chen, Irvin SY, Zack, Jerome A, Kiem, Hans-Peter, and Kitchen, Scott G

Subjects
CD4-Positive T-Lymphocytes, Hematopoietic Stem Cells, Animals, Macaca nemestrina, HIV Infections, Simian Acquired Immunodeficiency Syndrome, Disease Models, Animal, Receptors, Antigen, T-Cell, Recombinant Fusion Proteins, Immunotherapy, Hematopoietic Stem Cell Transplantation, Cell Differentiation, Cell Lineage, Male, Genetic Therapy, Immunization, Vaccine Related, Regenerative Medicine, Genetics, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Gene Therapy, Biotechnology, Stem Cell Research - Nonembryonic - Human, HIV/AIDS, Cancer, Infectious Diseases, Transplantation, 5.2 Cellular and gene therapies, Infection, Virology, Microbiology, Immunology, Medical Microbiology
Abstract

Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for various forms of cancer and show promise in treating HIV-1 infection. However, significant limitations are persistence and whether peripheral T cell-based products can respond to malignant or infected cells that may reappear months or years after treatment remains unclear. Hematopoietic Stem/Progenitor Cells (HSPCs) are capable of long-term engraftment and have the potential to overcome these limitations. Here, we report the use of a protective CD4 chimeric antigen receptor (C46CD4CAR) to redirect HSPC-derived T-cells against simian/human immunodeficiency virus (SHIV) infection in pigtail macaques. CAR-containing cells persisted for more than 2 years without any measurable toxicity and were capable of multilineage engraftment. Combination antiretroviral therapy (cART) treatment followed by cART withdrawal resulted in lower viral rebound in CAR animals relative to controls, and demonstrated an immune memory-like response. We found CAR-expressing cells in multiple lymphoid tissues, decreased tissue-associated SHIV RNA levels, and substantially higher CD4/CD8 ratios in the gut as compared to controls. These results show that HSPC-derived CAR T-cells are capable of long-term engraftment and immune surveillance. This study demonstrates for the first time the safety and feasibility of HSPC-based CAR therapy in a large animal preclinical model.

Published
2017

60. Trapped fractional charges at bulk defects in topological insulators

Author

Peterson, Christopher W., Li, Tianhe, Jiang, Wentao, Hughes, Taylor L., and Bahl, Gaurav

Subjects
Electric insulators -- Product defects and recalls -- Materials, Electric charge and distribution -- Control, Algebraic topology -- Observations, Crystals -- Structure -- Product defects and recalls, Topology -- Observations, Electrical equipment and supplies industry -- Product defects and recalls, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Topological crystalline insulators (TCIs) can exhibit unusual, quantized electric phenomena such as fractional electric polarization and boundary-localized fractional charge.sup.1-6. This quantized fractional charge is the generic observable for identification of TCIs that lack clear spectral features.sup.5-7, including ones with higher-order topology.sup.8-11. It has been predicted that fractional charges can also manifest where crystallographic defects disrupt the lattice structure of TCIs, potentially providing a bulk probe of crystalline topology.sup.10,12-14. However, this capability has not yet been confirmed in experiments, given that measurements of charge distributions in TCIs have not been accessible until recently.sup.11. Here we experimentally demonstrate that disclination defects can robustly trap fractional charges in TCI metamaterials, and show that this trapped charge can indicate non-trivial, higher-order crystalline topology even in the absence of any spectral signatures. Furthermore, we uncover a connection between the trapped charge and the existence of topological bound states localized at these defects. We test the robustness of these topological features when the protective crystalline symmetry is broken, and find that a single robust bound state can be localized at each disclination alongside the fractional charge. Our results conclusively show that disclination defects in TCIs can strongly trap fractional charges as well as topological bound states, and demonstrate the primacy of fractional charge as a probe of crystalline topology. It is experimentally shown that crystallographic defects may trap fractional charges, as well as topological states, in the bulk of topological crystalline insulators., Author(s): Christopher W. Peterson [sup.1] , Tianhe Li [sup.2] , Wentao Jiang [sup.1] , Taylor L. Hughes [sup.2] , Gaurav Bahl [sup.3] Author Affiliations: (1) Department of Electrical and Computer [...]

Published
2021
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66. Long-Term Follow-Up of the RESORT Study (E4402): A Randomized Phase III Comparison of Two Different Rituximab Dosing Strategies for Low–Tumor Burden Follicular Lymphoma

Author

Kahl, Brad S., primary, Jegede, Opeyemi A., additional, Peterson, Christopher, additional, Swinnen, Lode J., additional, Habermann, Thomas M., additional, Schuster, Stephen J., additional, Weiss, Matthias, additional, Fishkin, Paul A., additional, Fenske, Timothy S., additional, and Williams, Michael E., additional

Published
2024
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67. SEC Publishes Final Rule For SPAC Transactions, Bringing Much-Needed Clarity And Certainty To Rules For Capital Raising

Author

Peterson, Christopher

Subjects
United States. Securities and Exchange Commission -- Powers and duties, Publicly held corporations -- Laws, regulations and rules, Going public (Securities) -- Laws, regulations and rules, Capital investments -- Laws, regulations and rules, Government regulation, Company public offering, Capital investment, Business, international
Abstract

On January 24, the SEC adopted its final rule (the Final Rule) with respect to special-purpose acquisition companies (SPACs) and mergers of SPACs with private businesses that result in the [...]

Published
2024

69. Monkey Trouble

Author

Peterson, Christopher

Subjects
Literature, Posthumanism, speculative realism, Object Oriented Ontology, animal studies, Jacques Derrida, Edmund Husserl, Walt Whitman, J.M. Coetzee, Alfonso Cuarón, Lars von Trier, Alterity, Democracy, Immanuel Kant, Sovereignty
Abstract

Engaging with recent theoretical developments in speculative realism and object oriented ontology, ape and parrot language studies, along with literary texts by J.M. Coetzee, Charles Chesnutt, and Walt Whitman, and films by Alfonso Cuarón and Lars von Trier, Monkey Trouble argues that the turn toward immanence in contemporary posthumanism promotes a cosmocracy that absolves one from engaging in those discriminatory decisions that condition hospitality as such. Anthropocentrism cannot be displaced through a logic of reversal that elevates immanence above transcendence, horizontality over verticality. This decentering must cultivate instead a human/nonhuman relationality that affirms the immanent transcendency spawned by our phantasmatic humanness.

Published
2017

70. Cell and Gene Therapy for HIV Cure

Author

Peterson, Christopher W., Kiem, Hans-Peter, Compans, Richard W, Series Editor, Malissen, Bernard, Series Editor, Aktories, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Galan, Jorge E, Series Editor, Ahmed, Rafi, Series Editor, Palme, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Akira, Shizuo, Series Editor, Silvestri, Guido, editor, and Lichterfeld, Mathias, editor

Published
2018
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72. Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial

Author

Vergote, Ignace, Scambia, Giovanni, Park, Sang Yoon, Song, Yong Sang, Makarova, Yulia, Trinidad, Joshua, Ngan, Hextan Yuen Sheung, Bamias, Aristotelis, Aravantinos, Gerasimos, Nam, Joo-Hyun, Gorbunova, Vera, Krikunova, Ludmila, Bae, Duk-Soo, Arija, Jose Angel Arranz, Mirza, Mansoor Raza, Zamagni, Claudio, Papandreou, Christos, Raspagliesi, Francesco, Lisyanskaya, Alla, Benzaquen, Ana Oaknin, Tognon, Germana, Ortega, Eugenia, Herraez, Antonio Casado, Buscema, Joseph, Green, Andrew, Burger, Robert, Sakaeva, Dina, Sanchez, Andres Redondo, Ghamande, Sharad, King, Laurel, Petru, Edgar, Peen, Ulla, Takeuchi, Satoshi, Ushijima, Kimio, Martin, Antonio Gonzalez, Kamelle, Scott, Carney, Michael, Marth, Christian, Forget, Frédéric, Bentley, James, Sehouli, Jalid, Colombo, Nicoletta, Zola, Paolo, Kato, Hidenori, Fadeeva, Natalya, Gotovkin, Evgeny, Vladimirov, Vladimir, Marin, Margarita Romeo, Alia, Eva Guerra, Shahin, Mark, Bhoola, Snehalkumar, Tewari, Krishnansu, Anderson, Daniel, Honhon, Brigitte, Pelgrims, Joseph (Gino), Oza, Amit, Jimenez, Jesus Garcia-Donas, Hansen, Vincent, O'Malley, David, Benjamin, Ivor, Renard, Vincent, Van den Bulck, Heidi, Meier, Werner, Haenle, Claudia, Koumakis, Georgios, Yokota, Harushige, Popov, Vadim, Bradley, William, Wenham, Robert, Reid, Robert, McNamara, Donna, Friedman, Richard, Barlin, Joyce, Spirtos, Nicola, Chapman, Julia, Sevelda, Paul, Huizing, Manon, Lamot, Caroline, Goffin, Frédéric, Hondt, Lionel D, Covens, Allan, Spadafora, Silvana, Rautenberg, Beate, Reimer, Toralf, Möbus, Volker, Hilpert, Felix, Gropp-Meier, Martina, Savarese, Antonella, Pignata, Sandro, Verderame, Francesco, Mizuno, Mika, Takano, Hirokuni, Ottevanger, Petronella, Velasco, Andres Poveda, Palacio-Vazquez, Isabel, Law, Amy, McIntyre, Kristi, Teneriello, Michael, Fields, Abbie, Lentz, Samuel, Street, Daron, Schwartz, Benjamin, Mannel, Robert, Lim, Peter, Pulaski, Heather, Janni, Wolfgang, Zorr, Andreas, Karck, Ulrich, Cheng, Ashley Chi Kin, Sorio, Roberto, Gridelli, Cesare, Aoki, Daisuke, Oishi, Tetsuro, Hirashima, Yasuyuki, Boere, Ingrid, Ferrer, Esther Falco, Braly, Patricia, Wilks, Sharon, Lee, Christine, Schilder, Jeanne, Veljovich, Dan, Secord, Angeles, Davis, Kevin, Rojas-Espaillat, Luis, Lele, Shashikant, DePasquale, Stephen, Squatrito, Robert, Schauer, Christian, Dirix, Luc, Vuylsteke, Peter, Joosens, Eric, Provencher, Diane, Lueck, Hans-Joachim, Hein, Alexander, Burges, Alexander, Canzler, Ulrich, Park-Simon, Tjoung-Won, Griesinger, Frank, Gadducci, Angiolo, Alabiso, Oscar, Okamoto, Aikou, Sawasaki, Takashi, Saito, Toshiaki, Ibañez, Ana Herrero, Calomeni, Coralia, Spillman, Monique, Choksi, Janak, Taylor, Nicholas, Muller, Carolyn, Moore, David, DiSilvestro, Paul, Cunningham, Mary, Rose, Peter, Oppelt, Peter, Verhoeven, Didier, Graas, Marie-Pascale, Ghatage, Prafull, Tonkin, Katia, Kurzeder, Christian, Schnappauf, Benjamin, Müller, Volkmar, Schmalzrie, Hannah, Kalofonos, Haralambos, Bruzzone, Milena, Kroep, Judith, Diaz, Cristina Caballero, Garcia, Jeronimo Martinez, Polo, Susana Hernando, Garrison, Mitchell, Rocconi, Rodney, Andrews, Stephen, Bristow, Robert, McHale, Michael, Basil, Jack, Houck III, William, Bell, Maria, Cosin, Jonathan, Modesitt, Susan, Kendrick, James, Wade III, James, Wong, Cheung, Evans, Anthony, Buekers, Thomas, Vanderkwaak, Timothy, Ferriss, James, Darus, Christopher, DAndre, Stacy, Higgins, Robert, Monk, Bradley, Bakkum-Gamez, Jamie, DeMars, Leslie, Van Le, Linda, Puls, Larry, Trehan, Shruti, LaPolla, James, Michelson, Elizabeth Dickson, Merchant, Joseph, Peterson, Christopher, Reid, Gary, Seago, Donald, Zweizig, Susan, Gajewski, Walter, Panwalkar, Amit, Leikermoser, Rudolf, Bogner, Gerhard, Debruyne, Philip, D'hondt, Randal, Berteloot, Patrick, Kerger, Joseph, Biagi, James, Castonguay, Vincent, Welch, Stephen, Muhic, Aida, Heubner, Martin, Grischke, Eva-Maria, Rack, Brigitte, Fleisch, Markus, Lordick, Florian, Pectasides, Dimitrios, Ho, Wing Ming, Selvaggi, Luigi, Vasquez, Flavia Morales, Villanueva, William Orlando Brito, Alavez, Alejandro Molina, Kessels, Lonneke, Bertran, Ana Santaballa, Fernandez, Cesar Mendiola, Fabregat, Miguel Beltran, Del Prete, Salvatore, Elkas, John, Cecchi, Gary, Kumar, Pallavi, Huh, Warner, Messing, Mark, Karimi, Misagh, Kelley, Ann, Edraki, Babak, Mutch, David, Leiserowitz, Gary, Anderson, Jeanne, Lentz, Scott, Chambers, Setsuko, Morris, Robert, Waggoner, Steven, Gordon, Alan, Method, Michael, Johnson, Peter, Lord, Raymond, Drake, Janet, Sivarajan, Kulumani, Midathada, Madhu, Rice, Kristen, Wadsworth, Troy, Pavelka, James, Edwards, Robert, Miller, David Scott, Ford, Patricia Locantore, Hurteau, Jean, Bender, David, Schimp, Veronica, Creasman, William, Lerner, Rachel, Chamberlain, Donald, Kueck, Angela, McDonald, John, Malad, Salman, Robinson-Bennett, Bernice, Davidson, Susan, Krivak, Thomas, Lestingi, Timothy, Arango, Hector, Berard, Paul, Finkelstein, Karen, Gaur, Rakesh, Krasner, Carolyn, Ueland, Frederick, Talmage, Lance, Yamada, Seiko, Sutton, Gregory, Potkul, Ronald, Prasad-Hayes, Monica, Osborne, Janet, Celano, Paul, Thigpen, James, Sharma, Sudarshan, Schilder, Russell, Tammela, Jonathan, Kemeny, Mary, Brown, Amy, Eisenhauer, Eric, Williams, James, Rowland, Kendrith, Nahum, Kenneth, Burke, James, Dar, Zahid, Fleming, Nicole, Gibb, Randall, Guirguis, Alfred, Herzog, Thomas, John, Veena, Kumar, Santhosh, Kamat, Aparna, Kassar, Mohamad, Leitao, Mario, Levine, Lyuba, Mendez, Luis, Patel, Dhimant, Berry, Emily, Warshal, David, Wolf, Judith, Zarwan, Corrine, Collins, Yvonne, Spitzer, Gary, Miller, Brigitte, Einstein, Mark, O'Malley, David M, Van Calster, Ben, Park, Sang-Yoon, del Campo, Josep M, Wenham, Robert M, Covens, Al, Raza Mirza, Mansoor, Kroep, Judith R, Ma, Haijun, Pickett, Cheryl A, and Monk, Bradley J

Published
2019
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73. Designing eco‐evolutionary experiments for restoration projects: Opportunities and constraints revealed during stickleback introductions.

Author

Hendry, Andrew P., Barrett, Rowan D. H., Bell, Alison M., Bell, Michael A., Bolnick, Daniel I., Gotanda, Kiyoko M., Haines, Grant E., Lind, Åsa J., Packer, Michelle, Peichel, Catherine L., Peterson, Christopher R., Poore, Hilary A., Massengill, Robert L., Milligan‐McClellan, Kathryn, Steinel, Natalie C., Sanderson, Sarah, Walsh, Matthew R., Weber, Jesse N., and Derry, Alison M.

Subjects
LAKE restoration, STICKLEBACKS, RESTORATION ecology, THREESPINE stickleback, AQUATIC ecology, FOREST restoration
Abstract

Eco‐evolutionary experiments are typically conducted in semi‐unnatural controlled settings, such as mesocosms; yet inferences about how evolution and ecology interact in the real world would surely benefit from experiments in natural uncontrolled settings. Opportunities for such experiments are rare but do arise in the context of restoration ecology—where different "types" of a given species can be introduced into different "replicate" locations. Designing such experiments requires wrestling with consequential questions. (Q1) Which specific "types" of a focal species should be introduced to the restoration location? (Q2) How many sources of each type should be used—and should they be mixed together? (Q3) Which specific source populations should be used? (Q4) Which type(s) or population(s) should be introduced into which restoration sites? We recently grappled with these questions when designing an eco‐evolutionary experiment with threespine stickleback (Gasterosteus aculeatus) introduced into nine small lakes and ponds on the Kenai Peninsula in Alaska that required restoration. After considering the options at length, we decided to use benthic versus limnetic ecotypes (Q1) to create a mixed group of colonists from four source populations of each ecotype (Q2), where ecotypes were identified based on trophic morphology (Q3), and were then introduced into nine restoration lakes scaled by lake size (Q4). We hope that outlining the alternatives and resulting choices will make the rationales clear for future studies leveraging our experiment, while also proving useful for investigators considering similar experiments in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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79. Optimistic Explanatory Style

Author

Peterson, Christopher, Steen, Tracy A., Snyder, C. R., book editor, Lopez, Shane J., book editor, Edwards, Lisa M., book editor, and Marques, Susana C., book editor

Published
2021
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83. Multidecadal meta-analysis of reproductive parameters of female red snapper (Lutjanus campechanus) in the northern Gulf of Mexico

Author

Brown-Peterson, Nancy J., Peterson, Christopher R., and Fitzhugh, Gary R.

Subjects
Gulf of Mexico -- Natural history, Red snapper -- Sexual behavior, Fishes, Zoology and wildlife conservation
Abstract

Abstract--Stocks of red snapper (Lutjanus campechanus) exhibited a dramatic decline in abundance in the northern Gulf of Mexico (GOM) between 1960 and 1991; management regulations implemented since 1991 have resulted [...]

Published
2019
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86. Preface

Author

Peterson, Christopher

Published
2004

97. VISCOELASTIC EFFECT OF THIN SHELL FIBER REINFORCED COMPOSITES USED FOR DEPLOYABLE SPACE STRUCTURES

Author

Peterson, Christopher Van

Subjects
Mechanical engineering, Materials Science, Aerospace engineering, Biaxial Bending, Composites, Creep, Relaxation, STEM, Viscoelasticity
Abstract

Composite tape springs, and a related design called a storable tubular extendable member (STEM), are used in aerospace structures as deployment mechanisms for various components on satellites, e.g., solar arrays, antennae, booms. Laminates used in their designs must be thin to prevent micro-buckling when deformed into compact stowed configurations. As a result, they have matrix dominated properties that viscoelastically evolve in time and can result in deployable space structure designs with reduced deployment torque and deployed stiffness. In order to understand how to mitigate the effects of viscoelasticity in STEM designs, this dissertation explores how laminate stacking sequence and fiber orientation affect composite viscoelastic behavior and incorporates this knowledge in a method to model the performance of a particular biaxially stowed and then deployed STEM design.To explore the effect that stacking sequence and fiber orientation have on viscoelastic behavior, tensile and four-point bend creep tests are performed on neat resin, unidirectional and plain weave lamina, and 3-ply [45PW/0/45PW] and 4-ply [0/45PW/45PW/0] laminate samples, all composed of the same epoxy resin and carbon fiber system. The results of the creep tests indicate that fibers placed in the load path, e.g., surface plies in composites under flexure loads or fibers in the direction of tensile loads, mitigate the viscoelastic creep and relaxation of the composites. The presence of elastic fibers also increases the stiffness of the laminae and laminates and reduces the degree to which they creep. The proportional viscoelastic change in the transient properties of the neat resin, lamina, and laminate, e.g., percent strain change over time at fixed stress between the initial elastic response and the equilibrium response of the material, are compared to one another. The results from indicate that the viscoelastic behavior of the resin system composing the matrix of the laminae and laminates is unchanged by the presence of fibers.An analytical model is developed to predict the viscoelastic behavior of a STEM after prolonged deformation in a state of biaxial bending, e.g., the stowed configuration. The model predicts the extent to which biaxial bending moments relax during the period of time a viscoelastic composite STEM is subjected to a state of constant biaxial bending curvature (i.e., stowage) and then predicts the resulting recovery curvature and moments after the stowed STEM is allowed to deploy. The predictions of the model for a one-dimensional beam in bending are shown to compare favorably to the predictions of validated one-dimensional beam models found in the literature.Knowledge of a STEM’s laminate flexural creep and relaxation properties is needed for the model to predict the biaxial bending curvature and moments of a STEM design. Since the available test data provides information on creep performance only, viscoelastic inversion methods are needed to obtain relaxation information. Several approaches are explored for converting the creep compliance and flexure properties that are ascertained by the tensile and four-point bending creep tests. A review of one-dimensional viscoelastic inversion methods such as Gutierrez-Lemini’s exact method shows them not to be applicable for inversion of the multidimensional creep properties of the anisotropic laminae and laminates tested for this dissertation. To accomplish the task of inverting the creep data, a Laplace transform based numerical method is developed for multidimensional viscoelastic materials. The creep properties for the neat resin, unidirectional and plain weave laminae, and 3-ply and 4-ply laminates are inverted using the Laplace transform based numerical inversion method. The flexure properties cannot be inverted because the axial/transverse flexure creep properties could not be measured by the four-point bend test method utilized. To acquire the relevant information, the inverted unidirectional and plain weave tensile creep properties are used as inputs for a viscoelastic version of classical laminate theory to predict the relaxation flexure properties of the unidirectional and plain weave laminae, and 3-ply and 4-ply laminates.

Published
2020

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