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52. Patterns of care and outcome of CIC ‐rearranged sarcoma patients: A nationwide study of the French sarcoma group

Author

Brahmi, Mehdi, primary, Gaspar, Nathalie, additional, Gantzer, Justine, additional, Toulmonde, Maud, additional, Boudou‐Rouquette, Pascaline, additional, Bompas, emmanuelle, additional, Firmin, Nelly, additional, Valentin, Thibaud, additional, Cancel, Mathilde, additional, Duffaud, Florence, additional, Bertucci, Francois, additional, Perrin, Christophe, additional, Dufresne, Armelle, additional, Marec‐Bérard, Perrine, additional, Jean‐Denis, Myriam, additional, Ray‐Coquard, Isabelle, additional, Le Loarer, Francois, additional, Pierron, Gaille, additional, Tirode, Franck, additional, Blay, Jean‐Yves, additional, and Watson, Sarah, additional

Published
2022
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54. Lung cancer trends and tumor characteristic changes over 20 years (2000–2020): Results of three French consecutive nationwide prospective cohorts’ studies

Author

Debieuvre, Didier, primary, Molinier, Olivier, additional, Falchero, Lionel, additional, Locher, Chrystèle, additional, Templement-Grangerat, Dorine, additional, Meyer, Nicolas, additional, Morel, Hugues, additional, Duval, Yannick, additional, Asselain, Bernard, additional, Letierce, Alexia, additional, Trédaniel, Jean, additional, Auliac, Jean-Bernard, additional, Bylicki, Olivier, additional, Moreau, Lionel, additional, Fore, Mathieu, additional, Corre, Romain, additional, Couraud, Sébastien, additional, Cortot, Alexis, additional, Freijat, Faraj Al, additional, Sheikh, Waad Al, additional, Alizon, Claire, additional, Amrane, Karim, additional, Auvray, Etienne, additional, Banciu, Nicolae, additional, Bedossa, Alexandra, additional, Belhaj, Issam, additional, Belle, Antoine, additional, Belmont, Laure, additional, Benmammar, Kheir Eddine, additional, Bernardi, Marie, additional, Beynel, Pascal, additional, Bigot, Fréderic, additional, Bizieux-Thaminy, Acya, additional, Blanchet-Legens, Anne-Sophie, additional, Bonnefoy, Philippe, additional, Bordier, Soraya, additional, Bravard, Anne-Sophie, additional, Briens, Éric, additional, Brun, Philippe, additional, Bugnet, Anne-Sophie, additional, Chablais, Laetitia, additional, Chiappa, Anne-Marie, additional, Chikouche, Reda, additional, Christiann, François, additional, Clarot, Caroline, additional, Courdeau-Labourie, Joelle, additional, Crequit, Jacky, additional, Dayen, Charles, additional, De chabot, Gonzague, additional, Debieuvre, Didier, additional, Decroisette, Chantal, additional, Dehette, Stéphanie, additional, Delafosse, Christian, additional, Delclaux, Bertrand, additional, Delmas, Christina, additional, Demontrond, Pierre, additional, Dot, Jean-Marc, additional, Dujon, Cécile, additional, Dumont, Patrick, additional, Dussopt, Christine, additional, Duval, Fatima, additional, Khanjari, Fethi El, additional, Fouet, Kevin, additional, Francois, Hugues, additional, Ghalloussi-Tebai, Yannick, additional, Goarant, Éric, additional, Godbert, Benoît, additional, Goupil, François, additional, Haouachi, Rym, additional, Hauss, Pierre-Alexandre, additional, Jaafar, Mohamad, additional, Jarjour, Baihas, additional, Jeandeau, Serge, additional, Julien, Sylvie, additional, Kraemer, Jean Philippe, additional, Kuntz, Pierre, additional, Lamotte, Florence, additional, Larive, Sébastien, additional, Laurent, Thomas, additional, Floch, Hervé Le, additional, Garff, Gwenaëlle Le, additional, Treut, Jacques Le, additional, Lecuyer, Emmanuelle, additional, Lefoll, Christine, additional, Leleu, Olivier, additional, Doubliez, Marguerite Lepoulain, additional, Levrat, Virginie, additional, Loutski-Vettese, Sandrine, additional, Maetz, Edith, additional, Magne, Fanny, additional, Maincent, Cécile, additional, Mairovitz, Alexa, additional, Marichy, Catherine, additional, Marion, Nancy, additional, Marquette, David, additional, Martignac, Bénédicte, additional, Martinez, Stéphanie, additional, Marty, Clothilde, additional, Masson, Philippe, additional, Maurer, Cyril, additional, Meniai, Vincent, additional, De Faverges, Geoffroy Milliet, additional, Monnet, Isabelle, additional, Mosser, Laurent, additional, Neidhardt, Anne-Catherine, additional, Nunes, David, additional, Obert, Julie, additional, Pante, Vanessa, additional, Paysse, Magalie, additional, Pegliasco, Herve, additional, Peloni, Jean-Michel, additional, Perrin, Christophe, additional, Petit, Lidia, additional, Picaud, Marjorie, additional, Pinsolle, Julian, additional, Popa, Mihai, additional, Portel, Laurent, additional, Quieffin, Jean, additional, Rabut, Hong, additional, Redureau, Élise, additional, Renault, David, additional, Renault, Patrick Aldo, additional, Rizzo, Claudia, additional, Russier, Maud, additional, Sabatini, Marielle, additional, Saelens, Thierry, additional, Schneider, Sophie, additional, Slaouti, Philippe, additional, Stoven, Luc, additional, Tack, Vincent, additional, Tavernier, Jean-Yves, additional, Thirard, Laurence, additional, Thomassin, Séverine, additional, Tiercin, Marie, additional, Tredaniel, Jean, additional, Tudor, Andreea, additional, Turlotte, Amélie, additional, Vincent, Colette, additional, and Virally, Jérôme, additional

Published
2022
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55. Additional file 1 of Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trial

Author

Nay, Mai-Anh, Hindre, Raphaël, Perrin, Christophe, Clément, Jérémy, Plantier, Laurent, Sève, Aymeric, Druelle, Sylvie, Morrier, Marine, Lainé, Jean-Baptiste, Colombain, Léa, Corvaisier, Grégory, Bizien, Nicolas, Pouget-Abadie, Xavier, Bigot, Adrien, Jamard, Simon, Nyamankolly, Elsa, Planquette, Benjamin, Fossat, Guillaume, and Boulain, Thierry

Abstract

Additional file 1. Protocol.

Published
2023
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56. Additional file 2 of Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trial

Author

Nay, Mai-Anh, Hindre, Raphaël, Perrin, Christophe, Clément, Jérémy, Plantier, Laurent, Sève, Aymeric, Druelle, Sylvie, Morrier, Marine, Lainé, Jean-Baptiste, Colombain, Léa, Corvaisier, Grégory, Bizien, Nicolas, Pouget-Abadie, Xavier, Bigot, Adrien, Jamard, Simon, Nyamankolly, Elsa, Planquette, Benjamin, Fossat, Guillaume, and Boulain, Thierry

Abstract

Additional file 2. Supplementary files.

Published
2023
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64. Does awake prone positioning prevent the use of mechanical respiratory support or death in COVID-19 patients on standard oxygen therapy hospitalised in general wards? A multicentre randomised controlled trial: the PROVID-19 protocol

Author

Nay, Mai-Anh, primary, Planquette, Benjamin, additional, Perrin, Christophe, additional, Clément, Jérémy, additional, Plantier, Laurent, additional, Sève, Aymeric, additional, Druelle, Sylvie, additional, Morrier, Marine, additional, Lainé, Jean-Baptiste, additional, Colombain, Léa, additional, Corvaisier, Grégory, additional, Bizien, Nicolas, additional, Pouget-Abadie, Xavier, additional, Bigot, Adrien, additional, Bernard, Louis, additional, Nyamankolly, Elsa, additional, Fossat, Guillaume, additional, and Boulain, Thierry, additional

Published
2022
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66. Management and Outcomes of Pediatric, Adolescent and Young Adult Sarcoma Patients: Results from the French Nationwide Database NETSARC

Author

Kubicek, Pierre, primary, Cesne, Axel Le, additional, Lervat, Cyril, additional, Toulmonde, Maud, additional, Chevreau, Christine, additional, Duffaud, Florence, additional, Nail, Louis-Romée Le, additional, Morelle, Magali, additional, Gaspar, Nathalie, additional, Vérité, Cécile, additional, Castex, Marie-Pierre, additional, Penel, Nicolas, additional, Saada, Esma, additional, Causeret, Sylvain, additional, Bertucci, François, additional, Perrin, Christophe, additional, Bompas, Emmanuelle, additional, Orbach, Daniel, additional, Laurence, Valérie, additional, Piperno-Neumann, Sophie, additional, Anract, Philippe, additional, Rios, Maria, additional, Gentet, Jean-Claude, additional, Mascard, Éric, additional, Pannier, Stéphanie, additional, Blouin, Pascale, additional, Carrère, Sébastien, additional, Chaigneau, Loïc, additional, Soibinet-Oudot, Pauline, additional, Corradini, Nadège, additional, Boudou-Rouquette, Pascaline, additional, Ruzic, Jean-Christophe, additional, Lebrun-Ly, Valérie, additional, Dubray-Longeras, Pascale, additional, Varatharajah, Sharmini, additional, Lebbe, Céleste, additional, Ropars, Mickaël, additional, Kurtz, Jean-Emmanuel, additional, Guillemet, Cécile, additional, Lotz, Jean-Pierre, additional, Berchoud, Juliane, additional, Cherrier, Grégory, additional, Ducimetière, Françoise, additional, Chemin, Claire, additional, Italiano, Antoine, additional, Honoré, Charles, additional, Desandes, Emmanuel, additional, Blay, Jean-Yves, additional, Gouin, François, additional, and Marec-Bérard, Perrine, additional

Published
2022
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67. Health literacy in patients with cancer: A multicenter national study.

Author

Paillaud, Elena, primary, Galvin, Angéline, additional, Pulido, Marina, additional, Perrin, Christophe, additional, Grellety, Thomas, additional, Boudou-Rouquette, Pascaline, additional, Teyssonneau, Diego, additional, Ayati, Siavoshe, additional, Saint-Lezer, Arnaud, additional, Culine, Stephane, additional, Annonay, Mylene, additional, Soulem-Laviec, Heidi, additional, Boulahssass, Rabia, additional, Baldini, Capucine, additional, Tchalla, Achille, additional, Soubeyran, Pierre-Louis, additional, Lalet, Caroline, additional, Mebarki, Soraya, additional, Hue, Lucas, additional, and Mathoulin-Pélissier, Simone, additional

Published
2022
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70. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

Author

Cywes-Bentley, Colette, Skurnik, David, Zaidi, Tanweer, Roux, Damien, Deoliveira, Rosane B., Garrett, Wendy S., Lu, Xi, O'Malley, Jennifer, Kinzel, Kathryn, Zaidi, Tauqeer, Rey, Astrid, Perrin, Christophe, Fichorova, Raina N., Kayatani, Alexander K. K., Maira-Litràn, Tomas, Gening, Marina L., Tsvetkov, Yury E., Nifantiev, Nikolay E., Bakaletz, Lauren O., Pelton, Stephen I., Golenbock, Douglas T., and Pier, Gerald B.

Published
2013

77. Patterns of care and outcome of CIC‐rearranged sarcoma patients: A nationwide study of the French sarcoma group.

Author

Brahmi, Mehdi, Gaspar, Nathalie, Gantzer, Justine, Toulmonde, Maud, Boudou‐Rouquette, Pascaline, Bompas, emmanuelle, Firmin, Nelly, Valentin, Thibaud, Cancel, Mathilde, Duffaud, Florence, Bertucci, Francois, Perrin, Christophe, Dufresne, Armelle, Marec‐Bérard, Perrine, Jean‐Denis, Myriam, Ray‐Coquard, Isabelle, Le Loarer, Francois, Pierron, Gaille, Tirode, Franck, and Blay, Jean‐Yves

Subjects
EWING'S sarcoma, SARCOMA, LOG-rank test, DATABASES, DIAGNOSIS, DISEASE remission
Abstract

Background: CIC‐rearranged sarcomas (CIC‐RS) represent the most frequent subset of "Ewing‐like" undifferentiated small round cell sarcomas. These tumors tend to be more aggressive than Ewing sarcomas. Moreover, treatment strategy can differ according to teams. The primary aim of this retrospective study was to describe the characteristics, treatments, and outcome for patients with CIC‐RS included in the French NETSARC+ database. Methods: Pediatric and adult patients from 13 French centers with a diagnosis of CIC‐RS were registered from October 2008 to March 2021. Patients and tumors characteristics were collected from the national network NETSARC+ database (http://netsarc.sarcomabcb.org). CIC‐RS diagnosis was pathologically and molecularly confirmed with a central review by expert pathologists. Two groups of patients were studied: those treated as classical Ewing sarcomas (cohort EwS) and those treated as high‐grade soft tissue sarcomas (cohort STS) according to ESMO and/or EpSSG guidelines. Survival was calculated using the Kaplan–Meier method and the log‐rank test was used to compare survival. Results: Among 79 patients, the male/female sex ratio was 0.7 and the median age at diagnosis was 27 years (range 2–87). With a median follow‐up of 37 months, 39 patients died of the disease. Median overall survival from diagnosis was 18 months, with no significant difference between both cohorts (p = 0.9). Nevertheless, when focusing on patients with metastatic disease at diagnosis (N = 21), all patients from cohort STS died of disease while some patients from cohort EwS were still alive and in complete remission. Conclusion: FSG experience confirms the aggressive clinical course of CDS patients regardless of chemotherapy regimen. [ABSTRACT FROM AUTHOR]

Published
2023
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80. COVID-19 pneumonia: relationship between inflammation assessed by whole-body FDG PET/CT and short-term clinical outcome

Author

Dietz, Matthieu, Chironi, Gilles, Claessens, Yann-Erick, Farhad, Ryan Lukas, Rouquette, Isabelle, Serrano, Benjamin, Nataf, Valérie, Hugonnet, Florent, Paulmier, Benoît, Berthier, Frédéric, Keita-Perse, Olivia, Giammarile, Francesco, Perrin, Christophe, Faraggi, Marc, Fissore-Magdelein, C., Gabriel-Solean, S., Dahmani, B., Riss, I., Sorlin, P., Dupasquier, V., Pathak, A., Dugourd, C., Nicolai, M., Rijo, N., Beau, N., Magdelein, X., Olyve, F., Chaillou-Orpitz, S., Lépine, J., Lorillou, M., Maincent, C., Bertrand, S., Brunner, P., Dittlot, C., Fuerxer, F., Liberatore, M., Armando, G., Bouregba, M., Catineau, J., Garcia, P., and Tran, D.

Subjects
Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Glucose uptake, Inflammation, Gastroenterology, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Lung, Aged, Aged, 80 and over, business.industry, COVID-19, Heart, General Medicine, Middle Aged, medicine.disease, FDG PET/CT, Pneumonia, Treatment Outcome, medicine.anatomical_structure, Radiology Nuclear Medicine and imaging, Anaerobic glycolysis, Original Article, Female, Lymph Nodes, Lymph, Bone marrow, Radiopharmaceuticals, medicine.symptom, business
Abstract

Purpose [18F]-2-Fluoro-2-deoxy-D-glucose PET/CT (FDG PET/CT) is a sensitive and quantitative technic for detecting inflammatory process. Glucose uptake is correlated with an increased anaerobic glycolysis seen in activated inflammatory cells such as monocytes, lymphocytes, and granulocytes. The aim of the study was to assess the inflammatory status at the presumed peak of the inflammatory phase in non-critically ill patients requiring admission for COVID-19. Methods Patients admitted with COVID-19 were prospectively enrolled. FDG PET/CT was performed from day 6 to day 14 of the onset of symptoms. Depending on FDG PET/CT findings, patients’ profiles were classified as “inflammatory” or “low inflammatory.” FDG PET/CT data were compared with chest CT evolution and short-term clinical outcome. All inflammatory sites were reported to screen potential extra-pulmonary tropism. Results Thirteen patients were included. Maximum standardized uptake values ranged from 4.7 to 16.3 in lungs. All patients demonstrated increased mediastinal lymph nodes glucose uptake. Three patients (23%) presented mild nasopharyngeal, two patients (15%) bone marrow, and five patients (38%) splenic mild increase in glucose uptake. No patient had significant digestive focal or segmental glucose uptake. There was no significant physiological myocardial glucose uptake in all patients except one. There was no correlation between PET lung inflammatory status and chest CT evolution or short-term clinical outcome. Conclusion Inflammatory process at the presumed peak of the inflammatory phase in COVID-19 patients is obvious in FDG PET/CT scans. Glucose uptake is heterogeneous and typically focused on lungs. Trial registration NCT04441489. Registered 22 June 2020 (retrospectively registered). Electronic supplementary material The online version of this article (10.1007/s00259-020-04968-8) contains supplementary material, which is available to authorized users.

Published
2020

81. Livrable L5 - Nouveaux critères dynamiques de détection d'incidents pour les 2RM et analyse de l'utilisation réelle des capacités dynamiques d'un 2RM - Projet DYMOA

Author

Perrin, Christophe, Naude, Claire, Cheaibi, Sélim, Fournier, Jean-Yves, Serre, Thierry, and Cadic, Ifsttar

Subjects
SYSTEME DYNAMIQUE, TRAITEMENT DES DONNEES, CONDUITE NATURELLE, DEUX-ROUES MOTORISES, DEUX ROUES MOTORISE, CONDUITE DU VEHICULE, [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS], DETECTION D'INCIDENT, SOLLICITATION DYNAMIQUE, DETECTION D'INCIDENTS, COMPORTEMENT DYNAMIQUE
Abstract

Livrable L5 présentant les travaux du workpackage 5 du projet de recherche DYMOA+. L'objectif de la première partie de ce Work Package n°5 (WP5) est d'améliorer les critères de détection d'un incident pour un 2RM définis et utilisés dans le projet antérieur DYMOA. Les choix des variables et des seuils retenus pour ces critères semblent bien adaptés pour recueillir des évènements utiles pour le diagnostic d'infrastructure. En revanche ces critères s'avèrent moins efficaces pour différencier ces évènements d'incidents et surtout pour détecter les incidents "réels". Beaucoup trop de faux positifs sont enregistrés et de plus, des faux négatifs nous échappent certainement. Le but de ces travaux est donc d'améliorer ces critères ou d'en identifier de nouveaux, permettant si possible, de détecter des incidents "réels" et de les discerner des "fortes sollicitations". Pour cela il est probablement pertinent de combiner les variables et/ou de rajouter des notions de durée de dépassement de seuil. Une attention particulière est portée sur les variations de sollicitations, signes d'un effet de surprise, et annonciateurs de la présence d'une situation non souhaitée, plus proche de la définition d'un incident. Nous avons employé des méthodes utilisant des algorithmes d'apprentissage supervisé appliqués sur des jeux de données du projet DYMOA et d'autres données complémentaires acquises dans le cadre de ce projet DYMOA+. Ces méthodes donnent des résultats prometteurs qui restent à approfondir. La deuxième partie de ce WP5 présente l'exploitation complémentaire de données recueillies à la toute fin du projet DYMOA. Les données de conduite naturaliste de l'expérimentation DYMOA, acquises pendant une période de 18 mois avec 26 motos privées dans trois régions de France, ont été exploitées pour évaluer les niveaux de sollicitations réelles des 2RM. Il s'agissait plus particulièrement de données agrégées fournies pour l'ensemble des trajets, appelées « synthèses de parcours » et croisant les données accélérométriques et gyrométriques ainsi que les niveaux de vitesses. Cette étude vient compléter les résultats du livrable 3.3 de DYMOA, qui n'exploitait qu'une partie des données, concernant environ 3200 trajets. Sur 7500 trajets collectés, environ 6500 trajets ont pu être exploités pleinement, en correspondance avec les traces GPS qui permettent notamment de calculer les distances parcourues. La distance globale parcourue lors de ces trajets est d'environ 88000 km. Les résultats obtenus sur le jeu complet des données concernent en premier lieu les distributions globales, en temps passé, des accélérations longitudinale, latérale et verticale, et des vitesses de rotation tangage, roulis et lacet et de la vitesse, puis les valeurs extrêmes atteintes au moins une fois par les motocyclistes pour ces mêmes paramètres. La variabilité des comportements est ensuite illustrée allant d'une conduite souple à une conduite sportive. Les motocyclistes subissent rarement des niveaux élevés de sollicitations dynamiques. En accélération et décélération notamment, ils ne dépassent +-4 m/s² que 0,5% du temps. En ce qui concerne les virages, leur vitesse de roulis ne dépasse 20°/s que 0,8% du temps et leur vitesse de lacet que 2,1% du temps. Si l'on exclut le temps passé à l'arrêt ou à très faible vitesse (moins de 5 km/h), les motocyclistes passent 80 % de leur temps en dessous de 90 km/h et 3,2 % du temps au-dessus de 130 km/h, avec seulement 0,3 % du temps au-dessus de 150 km/h. Le comportement est très variable d'un motocycliste à l'autre, même sur les mêmes itinéraires. Ces données permettent de caractériser la dynamique des motos et de discriminer les différents comportements des motards.

Published
2022

82. Nouveaux critères dynamiques de détection d'incidents pour les 2RM et analyse de l'utilisation réelle des capacités dynamiques d'un 2RM

Author

Naude, Claire, Perrin, Christophe, and Cadic, Ifsttar

Subjects
2RM, PROFIL DE CONDUITE, EVENEMENT, TRAITEMENT DES DONNEES, ALGORITHMES SUPERVISES, CAPACITES DYNAMIQUE, [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS], POSTE DE CONDUITE, MOTOCYCLISTE, DEUX ROUES MOTORISE, ALGORITHME, DYNAMIQUE DU VEHICULE, CONDUITE DU VEHICULE, INCIDENT
Abstract

Les critères de Dymoa étaient adaptés pour le diagnostic d'infrastructure par l'analyse des incidents et évènements recueillis, et pour l'observation de l'utilisation réelle des capacités dynamiques d'un 2RM et des styles de conduite (entre 2RM, 2RM/4RM pour certaines grandeurs physiques uniquement). Ils sont par contre moins efficaces pour différencier les évènements des incidents. Dans DYMOA+ l'objectif était de les améliorer pour mieux identifier les incidents "réels" (variations de sollicitation signes d'un effet de surprise et d'une situation non souhaitée), et essayer de les différencier des "fortes sollicitations". Pour cela des algorithmes d'apprentissage supervisé ont été utilisés et appliqués à des jeux de données du projet Dymoa et des données complémentaires. Les données de conduite naturaliste de l'expérimentation DYMOA, acquises pendant une période de 18 mois avec 26 motos privées dans trois régions de France, ont été exploitées pour évaluer les niveaux de sollicitations réelles des 2RM. Il s'agissait plus particulièrement de données agrégées fournies pour l'ensemble des trajets, appelées « synthèses de parcours » et croisant les données accélérométriques et gyrométriques ainsi que les niveaux de vitesses. Cette étude vient compléter les résultats du livrable 3.3 de DYMOA [1], qui n'exploitait qu'une partie des données, concernant environ 3200 trajets. Sur 7500 trajets collectés, environ 6500 trajets ont pu être exploités pleinement, en correspondance avec les traces GPS qui permettent notamment de calculer les distances parcourues. La distance globale parcourue lors de ces trajets est d'environ 88000 km. Les résultats obtenus sur le jeu complet des données concernent en premier lieu les distributions globales, en temps passé, des accélérations longitudinale, latérale et verticale, et des vitesses de rotation tangage, roulis et lacet et de la vitesse, puis les valeurs extrêmes atteintes au moins une fois par les motocyclistes pour ces mêmes paramètres. La variabilité des comportements est ensuite illustrée allant d'une conduite souple à une conduite sportive.Les motocyclistes subissent rarement des niveaux élevés de sollicitations dynamiques. En accélération et décélération notamment, ils ne dépassent +-4 m/s² que 0,5% du temps. En ce qui concerne les virages, leur vitesse de roulis ne dépasse 20°/s que 0,8% du temps et leur vitesse de lacet que 2,1% du temps. Si l'on exclut le temps passé à l'arrêt ou à très faible vitesse (moins de 5 km/h), les motocyclistes passent 80 % de leur temps en dessous de 90 km/h et 3,2 % du temps au-dessus de 130 km/h, avec seulement 0,3 % du temps au-dessus de 150 km/h. Le comportement est très variable d'un motocycliste à l'autre, même sur les mêmes itinéraires. Ces données permettent de caractériser la dynamique des motos et de discriminer les différents comportements des motards.

Published
2022

83. Powered two-wheelers dynamics: determination of thresholds for the detection of emergency situations

Author

Perrin, Christophe, Costa, Laura, Naude, Claire, Serre, Thierry, and Cadic, Ifsttar

Subjects
VEHICLE DYNAMICS, SYSTEME DYNAMIQUE, DEUX ROUES MOTORISE, [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS], MOTORCYCLE, INCIDENT, DETECTION, THRESHOLD
Abstract

During naturalistic driving studies on Powered Two-Wheelers (PTW), a lot of data is acquired and difficulties appear to analyze all of it. So it seems interesting to focus on incident detection to shorten the driving sequences to study. Furthermore, a lot of studies were conducted concerning accidents, hence the decision to focus on near-crashes. This work deals with the determination of the most adequate PTW's dynamics parameters and their thresholds level allowing incidents detection. More than 60 experimental tests were performed on track (braking, slaloms, avoidance manoeuvres...) and on road with an instrumented motorcycle. Data recorded were speed, accelerations, rotation speeds, steering angle, steering torque, lean angle, brake pressure and trajectory. The method consists to observe these parameters in parallel with the feeling of the rider when performing manoeuvres. For example, the rider was not considering engaging strongly the motorcycle capacities for the slalom at 30km/h, while the avoidance manoeuvre at the same speed was considered as an emergency manoeuver. Then, criteria and thresholds have been determined to highlight the suddenness of a manoeuvre and the urgency of a situation. For the longitudinal dynamics, the retained conditions are: Longitudinal Speed greater than 10 km/h and Longitudinal Acceleration, under braking only, less than -6m/s². Concerning lateral dynamics, two possible criteria were retained: norm of Rotation Speed vector (Roll+Yaw+Pitch) greater than 80°/s or norm of Rotation Acceleration vector (Roll+Yaw+Pitch) greater than 300°/s². These criteria were afterwards validated on road travels were the rider ensures not to be confronted to any emergency situation. This study allows determining the PTW dynamics parameters that make possible the incident or near-crashes detection. About 30 vehicles were then instrumented to collect a large amount of data on the use of dynamics capacities. In the future these data collection will permit to refine these thresholds values.

Published
2022

91. Microvascular injuries, secondary edema, and inconsistencies in lung vascularization between affected and nonaffected pulmonary segments of non-critically ill hospitalized COVID-19 patients presenting with clinical deterioration

Author

Maincent, Cécile, primary, Perrin, Christophe, additional, Chironi, Gilles, additional, Baqué-Juston, Marie., additional, Berthier, Frédéric, additional, Paulmier, Benoît, additional, Hugonnet, Florent, additional, Dittlot, Claire, additional, Farhad, Ryan Lukas., additional, Renvoise, Julien, additional, Serrano, Benjamin, additional, Nataf, Valérie, additional, Mocquot, François, additional, Keita-Perse, Olivia, additional, Claessens, Yann-Erik, additional, and Faraggi, Marc, additional

Published
2022
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92. Improving Access to Affordable Quality-Assured Inhaled Medicines in Low- and Middle-Income Countries

Author

Stolbrink, Marie, primary, Chinouya, Martha J., additional, Jayasooria, Shamanthi, additional, Nightingale, Rebecca, additional, Evans-Hill, Laura, additional, Allan, Keith, additional, Allen, Haddijatou, additional, Balen, Julie, additional, Beacon, Tim, additional, Bissell, Karen, additional, Chakaya, Jeremiah, additional, Chiang, Chen-Yuan, additional, Cohen, Mark, additional, Devereux, Graham, additional, ElSony, Asma, additional, Halpin, David, additional, Hurst, John R., additional, Kiprop, Clement, additional, Lawson, Anna, additional, Macé, Cécile, additional, Makhanu, Agnes, additional, Makokha, Pancy, additional, Masekela, Refiloe, additional, Meme, Hellen, additional, Ming Khoo, Ee, additional, Nantanda, Rebecca, additional, Pasternak, Sarah, additional, Perrin, Christophe, additional, Reddel, Helen, additional, Rylance, Sarah, additional, Schweikert, Peter, additional, Were, Christopher, additional, Williams, Sian, additional, Winders, Tonya, additional, Yorgancioglu, Arzu, additional, Marks, Guy, additional, and Mortimer, Kevin, additional

Published
2022
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94. Treatment and outcomes of older versus younger women with HER2-positive metastatic breast cancer in the real-world national ESME database

Author

Annonay, Mylène, primary, Gauquelin, Lisa, additional, Geiss, Romain, additional, Ung, Mony, additional, Cristol-Dalstein, Laurence, additional, Mouret-Reynier, Marie-Ange, additional, Goncalves, Anthony, additional, Abadie-Lacourtoisie, Sophie, additional, Francois, Eric, additional, Perrin, Christophe, additional, Le Fel, Johan, additional, Lorgis, Véronique, additional, Servent, Véronique, additional, Uwer, Lionel, additional, Jouannaud, Christelle, additional, Leheurteur, Marianne, additional, Joly, Florence, additional, Campion, Loic, additional, Courtinard, Coralie, additional, Villacroux, Olivier, additional, Petit, Thierry, additional, Soubeyran, Pierre, additional, Terret, Catherine, additional, Bellera, Carine, additional, Brain, Etienne, additional, and Delaloge, Suzette, additional

Published
2021
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97. Neoadjuvant chemotherapy in high‐risk soft tissue sarcomas: A Sarculator‐based risk stratification analysis of the ISG‐STS 1001 randomized trial

Author

Pasquali, Sandro, primary, Palmerini, Emanuela, additional, Quagliuolo, Vittorio, additional, Martin‐Broto, Javier, additional, Lopez‐Pousa, Antonio, additional, Grignani, Giovanni, additional, Brunello, Antonella, additional, Blay, Jean‐Yves, additional, Tendero, Oscar, additional, Diaz‐Beveridge, Robert, additional, Ferraresi, Virginia, additional, Lugowska, Iwona, additional, Infante, Gabriele, additional, Braglia, Luca, additional, Merlo, Domenico Franco, additional, Fontana, Valeria, additional, Marchesi, Emanuela, additional, Donati, Davide Maria, additional, Palassini, Elena, additional, Bianchi, Giuseppe, additional, Marrari, Andrea, additional, Morosi, Carlo, additional, Stacchiotti, Silvia, additional, Bagué, Silvia, additional, Coindre, Jean Michel, additional, Dei Tos, Angelo Paolo, additional, Picci, Piero, additional, Bruzzi, Paolo, additional, Miceli, Rosalba, additional, Casali, Paolo Giovanni, additional, Gronchi, Alessandro, additional, Dani, Carla, additional, Villa, Chiara, additional, Messina, Antonella, additional, Rusi, Lorella, additional, Nuzzo, Anna Maria, additional, Nuzzo, Carmen, additional, De Paoli, Antonino, additional, Buonadonna, Angela, additional, Comandone, Alessandro, additional, Boglione, Antonella, additional, Livi, Lorenzo, additional, Greto, Daniela, additional, Riva, Nada, additional, Monti, Manuela, additional, Pennacchioli, Elisabetta, additional, De Pas, Tommaso, additional, Ippolito, Vincenzo, additional, Ledesma, Patrico, additional, Redondo, Andres, additional, Valverde, Claudia, additional, Bratos, Raquel, additional, Cruz, Josefina, additional, Martinez Trufero, Javier, additional, Cubedo, Ricardo, additional, Sevilla, Isabel, additional, Luna, Pablo, additional, Lopez, Rafael, additional, Sancho, Pilar, additional, Bally, Olivia, additional, Brahmi, Mehdi, additional, Ray‐Coquard, Isabelle, additional, Cassier, Philippe, additional, Marques, Nathalie, additional, Tassy, Luis, additional, Boudou‐Rouquette, Pascaline, additional, Tlemsani, Camille, additional, Alexandre, Jerome, additional, Goldwasser, Francois, additional, Bompas, Emmanuelle, additional, Rolland, Frederic, additional, Perrin, Christophe, additional, Talarmin, Marie, additional, Italiano, Antoine, additional, Toulmonde, Maud, additional, Laramas, Mathieu, additional, Bay, Jacques‐Olivier, additional, Dubray‐Longeras, Pascale, additional, and Rutkowski, Piotr, additional

Published
2021
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100. Microvascular Injury With Secondary Edema, Bronchoconstriction and Vasoconstriction of Non-involved Lung Parenchymal Segments May Contribute to Clinical Deterioration of Non-critically Ill Patients Hospitalized for SARS-CoV-2 Pneumonia Without Evidence of Pulmonary Embolism: A Preliminary Study.

Author

MAINCENT, Cécile, primary, PERRIN, Christophe, additional, CHIRONI, Gilles, additional, Baqué-Juston, Marie, additional, Berthier, Frédéric, additional, Paulmier, Benoit, additional, Hugonnet, Florent, additional, Dittlot, Claire, additional, Farhad, Ryan Lukas, additional, Renvoise, Julien, additional, Serrano, Benjamin, additional, Nataf, Valérie, additional, Mocquot, François, additional, Keita-Perse, Olivia, additional, Claessens, Yann-Erick, additional, and Faraggi, Marc, additional

Published
2021
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