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51. Optical mapping of late myocardial infarction in rats

Author

Mills, William R., Mal, Niladri, Forudi, Farhad, Popovic, Zoran B., Penn, Marc S., and Laurita, Kenneth R.

Subjects
Rats -- Health aspects, Rats -- Physiological aspects, Rattus -- Health aspects, Rattus -- Physiological aspects, Electrophysiology -- Analysis, Heart attack -- Research, Biological sciences
Abstract

Late myocardial infarction (MI) is associated with ventricular arrhythmias and sudden cardiac death. The exact mechanistic relationship between abnormal cellular electrophysiology, conduction abnormalities, and arrhythmogenesis associated with late MI is not completely understood. We report a novel, rapid dye superfusion technique to enable whole heart, high-resolution optical mapping of late MI. Optical mapping of action potentials was performed in normal rats and rats with anterior MI 7 days after left anterior descending artery ligation. Hearts from normal rats exhibited normal action potentials and impulse conduction. With the use of programmed stimulation to assess arrhythmia inducibility, 29% of hearts with late MI had inducible sustained ventricular tachycardia, compared with 0% in normal rats. A causal relationship between the site of infarction, abnormal action potential conduction (i.e., block and slow conduction), and arrhythmogenesis was observed. Optical mapping techniques can be used to measure highresolution action potentials in a whole heart model of late MI. This experimental model reproduces many of the electrophysiological characteristics (i.e., conduction slowing, block, and ventricular tachycardia) associated with MI in patients. Importantly, the results of this study can enhance our ability to understand the interplay between cellular heterogeneity, conduction abnormalities, and arrhythmogenesis associated with MI. arrhythmia; action potential; impulse propagation

Published
2006

54. Contributors

Author

Aaronson, Keith D., primary, Akhter, Shahab A., additional, Antaki, James F., additional, Ascheim, Deborah D., additional, Baldwin, J. Timothy, additional, Bermudez, Christian A., additional, Birks, Emma J., additional, Blume, Elizabeth D., additional, Bostic, Robin Roberts, additional, Boyle, Andrew, additional, Chen, Eric A., additional, Dembitsky, Walter, additional, Dew, Mary Amanda, additional, Gelijns, Annetine C., additional, Gelzinis, Theresa, additional, Gorodeski, Eiran Z., additional, Grady, Kathleen L., additional, Gregoric, Igor, additional, Hall, Jennifer L., additional, Heywood, J. Thomas, additional, Holman, William L., additional, Ivovic, Tina Ommaya, additional, Jaski, Brian, additional, Jeevanandam, Valluvan, additional, John, Ranjit, additional, Joseph, Francesca, additional, Kormos, Robert L., additional, Lockard, Kathleen L., additional, Mancini, Donna, additional, Miller, Leslie W., additional, Moskowitz, Alan, additional, Naka, Yoshifumi, additional, Pagani, Francis D., additional, K. Parides, Michael, additional, Patel-Raman, Sonna M., additional, Penn, Marc S., additional, Rathi, Shradha, additional, Rogers, Joseph G., additional, Russell, Stuart D., additional, Slaughter, Mark S., additional, Starling, Randall C., additional, Stevenson, Lynne Warner, additional, Teuteberg, Jeffrey, additional, Torre-Amione, Guillermo, additional, Wagner, William R., additional, Wampler, Richard K., additional, Watson, John T., additional, Wearden, Peter D., additional, Woolley, Joshua R., additional, and Young, James B., additional

Published
2012
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56. Contributors

Author

Akasaka, Takashi, primary, Akin, Ibrahim, additional, Alegria, Jorge R., additional, Almonacid, Alexandra, additional, Alviar, Carlos L., additional, Angiollilo, Dominick J., additional, Ansel, Gary M., additional, Anwaruddin, Saif, additional, Balzer, David T., additional, Bannan, Amr T., additional, Barsness, Gregory W., additional, Beekman, Robert H., additional, Beygui, Farzin, additional, Bittl, John A., additional, Bonhoeffer, Philipp, additional, Braendle, Michael, additional, Brennan, J. Matthew, additional, Brindis, Ralph, additional, Brochet, Eric, additional, Burke, David, additional, Büttner, Heinz Joachim, additional, Byrne, Robert, additional, Cannon, Christopher P., additional, Casserly, Ivan P., additional, Chacko, Matthews, additional, Chew, Derek P., additional, Cho, Leslie, additional, Coats, Louise, additional, Colombo, Antonio, additional, Costa, Marco A., additional, Cribier, Alain, additional, Croce, Kevin J., additional, Cura, Fernando, additional, Dehmer, Gregory J., additional, Dieter, Robert S., additional, Douglas, John S., additional, Eltchaninoff, Helene, additional, Eng, Marvin H., additional, Fitzgerald, Peter J., additional, Fuster, Valentin, additional, Garcia, Mario J., additional, Garg, Scot, additional, Goldstein, Jeffrey, additional, Goswani, Nilesh J., additional, Gray, William A., additional, Guagliumi, Giulio, additional, Hara, Hidehiko, additional, Hasan, Rani, additional, Henry, Timothy D., additional, Herrmann, Howard C., additional, Himbert, Dominique, additional, Hirsch, Russel, additional, Holmes, David R., additional, Honda, Yasuhiro, additional, Ince, Hüseyin, additional, Iung, Bernard, additional, Jneid, Hani, additional, Johnston, Samuel L., additional, Jollis, James G., additional, Kandzari, David, additional, Kapadia, Samir R., additional, Kastrati, Adnan, additional, Kereiakes, Dean J., additional, Kern, Morton J., additional, Khattab, Ahmed A., additional, Kim, Young-Hak, additional, Kirtane, Ajay J., additional, Kolluri, Raghu, additional, Krishnaswamy, Amar, additional, Kubo, Takashi, additional, Laham, Roger, additional, Lasala, John, additional, Lim, Michael J., additional, Lloyd, Thomas R., additional, Mark, Daniel, additional, Meier, Bernhard, additional, Montalescot, Gilles, additional, Moreno, Pedro R., additional, Moses, Jeffrey W., additional, Motiei, Arashk, additional, Mukherjee, Debabrata, additional, Naidu, Srihari S., additional, Nallamothu, Brahmajee K., additional, Narins, Craig R., additional, Ndrepepa, Gjin, additional, Neumann, Franz-Josef, additional, Nienaber, Christoph A., additional, Nobuyoshi, Masakiyo, additional, Palacios, Igor, additional, Park, Seung-Jung, additional, Patel, Uptal D., additional, Penn, Marc S., additional, Popma, Jeffrey, additional, Price, Matthew J., additional, Rajagopal, Vivek, additional, Ray, Kausik K., additional, Reiss, G. Russell, additional, Rocha-Singh, Krishna, additional, Roffi, Marco, additional, Rogers, R. Kevin, additional, Sanz, Javier, additional, Scheller, Bruno, additional, Schömig, Albert, additional, Schwartz, Robert S., additional, Serruys, Patrick, additional, Shirai, Shinichi, additional, Shishehbor, Mehdi H., additional, Silver, Mitchell J., additional, Simon, Daniel I., additional, Sirbu, Vasile, additional, Stankovic, Goran, additional, Stinis, Curtiss, additional, Stone, Gregg W., additional, Theodos, Gus, additional, Topaz, On, additional, Tron, Christophe, additional, Vahanian, Alec, additional, Van Tassel, Robert A., additional, White, Christopher J., additional, Williams, Matthew R., additional, Yock, Paul, additional, Yokoi, Hiroyoshi, additional, Zajarias, Alan, additional, Ziada, Khaled, additional, Ziskind, Andrew A., additional, and Zussman, Matthew, additional

Published
2012
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59. Prognostic value of myeloperoxidase in patients with chest pain

Author

Brennan, Marie-Luise, Penn, Marc S., Lente, Frederick van, Nambi, Vijay, Shishehbor, Mehdi H., Aviles, Ronnier J., Goormastic, Marlene, Pepoy, Michael L., McErlean, Ellen S., Topol, Eric J., Nissen, Steven E., and Hazen, Stanley L.

Subjects
Peroxidase -- Health aspects, Heart attack -- Diagnosis
Abstract

The presence of an enzyme called myeloperoxidase in the blood may identify patients with chest pain who may be having a heart attack, according to a study of 604 patients. This blood test can be used in patients who have a negative troponin T test because myeloperoxidase can appear in the blood even if the heart is not damaged. Troponin T is another blood test used to diagnose a heart attack.

Published
2003

61. Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy

Author

Shishehbor, Mehdi H., Aviles, Ronnier J., Brennan, Marie-Luise, Fu, Xiaoming, Goormastic, Marlene, Pearce, Gregory L., Gokce, Noyan, Keaney, John F., Jr., Penn, Marc S., Sprecher, Dennis L., Vita, Joseph A., and Hazen, Stanley L.

Subjects
Cardiovascular diseases -- Risk factors, Nitric oxide -- Adverse and side effects
Abstract

Nitric oxide can oxidize proteins, which may be a risk factor for cardiovascular disease. This was the conclusion of a study of 100 patients with cardiovascular disease and 108 healthy people. This study also showed that a group of drugs called statins can decrease the amount of these oxidized proteins, in addition to lowering blood cholesterol levels. Nitric oxide is a natural substance in the body that relaxes blood vessels.

Published
2003

65. List of Contributors

Author

Aardrup, Mary Pat, primary, Abejón, David, additional, Aboelsaad, Farag, additional, Abrams, Daniel J., additional, Ackermann, D. Michael, additional, Ackermans, Linda, additional, Al-Kaisy, Adnan A., additional, Alo’, Kenneth M., additional, Alterman, Ron L., additional, Paul Amar, Arun, additional, Amit, Guy, additional, Apuzzo, Michael L.J., additional, Ardell, Jeffrey L., additional, Aziz, Tipu Z., additional, Bakay, Roy A.E., additional, Baltuch, Gordon H., additional, Barolat, Giancarlo, additional, Basbaum, Allan I., additional, Bedder, Marshall D., additional, Bhadra, Narendra, additional, Bishop, Sharon, additional, Blaha, Charles D., additional, Bledsoe, Jonathan M., additional, Boulis, Nicholas, additional, Braz, Joao, additional, Broggi, Giovanni, additional, Burdick, Adam P., additional, Bussone, Gennaro, additional, Carpenter, Linda L., additional, Carr, Daniel B., additional, Cavuoto, James, additional, Celii, Amanda, additional, Chae, John, additional, Chang, Jin Woo, additional, Chen, Jiande D.Z., additional, Cohen, David B., additional, Cozzens, Jeffrey W., additional, Daneshgari, Firouz, additional, Davis, Ross, additional, Deer, Timothy R., additional, DeJongste, Mike J.L., additional, Doleys, Daniel M., additional, Donoghue, John P., additional, Dorman, Michael F., additional, Dresing, Thomas, additional, Durand, Dominique M., additional, Dyer, Allen R., additional, Eidelman, Anthony, additional, Esteller, Rosana, additional, Falowski, Steven, additional, Federici, Thais, additional, Fins, Joseph J., additional, Foote, Kelly D., additional, Foreman, Robert D., additional, Fountas, Kostas, additional, Franzini, Angelo, additional, Friedland, David, additional, Friehs, Gerhard M., additional, Gabriëls, Loes, additional, Gallagher, Rollin M., additional, Gildenberg, Philip L., additional, Goroszeniuk, Teodor, additional, Green, Alexander L., additional, Greenberg, Benjamin D., additional, Greenberg, Roy K., additional, Greene, David A., additional, Greenwood-Van Meerveld, Beverley, additional, Grill, Warren M., additional, de Groat, William C., additional, Groothuis, Katherine E., additional, Gupta, Shivani, additional, Halpern, Casey H., additional, Harb, Mouchir, additional, Hiner, Bradley C., additional, Hochberg, Leigh R., additional, Horsch, Svante, additional, Hsieh, Joseph C., additional, Jaggi, Jurg L., additional, Jenkins, Patrick D., additional, Jung, Hyun Ho, additional, Kapural, Leonardo, additional, Keith, Michael W., additional, Keravel, Yves, additional, Khan, K. Riaz, additional, Kilgore, Kevin L., additional, King-Stephens, David, additional, Knutson, Jayme, additional, Kopell, Brian Harris, additional, Kothari, Sandesha, additional, Krames, Elliot S., additional, Kumar, Krishna, additional, Kuyck, Kris van, additional, Lee, Kendall H., additional, Lee, Kwangdeok, additional, Lefaucheur, Jean Pascal, additional, Leone, Massimo, additional, Levy, Michael L., additional, Levy, Robert M., additional, Li, Dianyou, additional, Lind, Goran, additional, Linderoth, Bengt, additional, Litt, Brian, additional, Liu, Charles Y., additional, Machado, Andre G., additional, Machado, Sandra, additional, Marras, Carlo, additional, Mastracci, Tara M., additional, Mazzone, Paolo, additional, McAchran, Sarah, additional, McIntyre, Cameron C., additional, Meadows, Paul, additional, Memon, Muhammad, additional, Messina, Giuseppe, additional, Meyerson, Björn A., additional, Mogilner, Alon Y., additional, Moir, Liz, additional, Molnar, Gregory F., additional, Mortimer, J. Thomas, additional, Murro, Anthony M., additional, Nguyen, Jean Paul, additional, North, Richard B., additional, Nuttin, Bart, additional, Oh, Michael Y., additional, Okun, Michael S., additional, O’Reardon, John P., additional, Ossipov, Michael H., additional, Pancrazio, Joseph J., additional, Park, Yong D., additional, Peckham, P. Hunter, additional, Penn, Marc S., additional, Penn, Richard D., additional, Pereira, Erlick A.C., additional, Péréon, Yann, additional, Pilitsis, Julie G., additional, Polasek, Katharine H., additional, Popovic, Dejan, additional, Porreca, Frank, additional, Prager, Joshua P., additional, Quan, Kara J., additional, Rackley, Raymond, additional, Ranson, Matthew T., additional, Raoul, Sylvie, additional, Rauck, Richard L., additional, Reig, Enrique, additional, Rezai, Ali R., additional, Riley, Jonathan, additional, Rizzo, Joseph F., additional, Rosenow, Joshua M., additional, Roualdes, Vincent, additional, Samadani, Uzma, additional, Scarnati, Eugenio, additional, Schiff, Nicholas D., additional, Schulte, Stefan, additional, Sevcencu, Cristian, additional, Sharan, Ashwini D., additional, Sheffler, Lynne R., additional, Shellock, Frank G., additional, Shipley, Jane, additional, Sillay, Karl A., additional, Silverstein, Janna L., additional, Sluka, Kathleen A., additional, Smith, Howard S., additional, Smith, Joseph R., additional, Stanton-Hicks, Michael, additional, Starr, Philip A., additional, Stewart, Douglas, additional, Sun, Bomin, additional, Tagliati, Michele, additional, Taylor, Rod S., additional, Temel, Yasin, additional, Tringali, Giovenni, additional, Tyler, Dustin J., additional, Vasavada, Sandip, additional, Visser-Vandewalle, Veerle, additional, Walsh, Deirdre M., additional, Weiner, Richard L., additional, Weisz, Donald, additional, Whiting, Donald M., additional, Wilson, Blake S., additional, Winter, Jaleh, additional, Wyche, Margaret C., additional, Wu, Hemmings, additional, Yin, Jieyun, additional, and Zhan, Shikun, additional

Published
2009
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67. Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction: The TIME Randomized Trial

Author

Traverse, Jay H., Henry, Timothy D., Pepine, Carl J., Willerson, James T., Zhao, David X., Ellis, Stephen G., Forder, John R., Anderson, R. David, Hatzopoulos, Antonis K., Penn, Marc S., Perin, Emerson C., Chambers, Jeffrey, Baran, Kenneth W., Raveendran, Ganesh, Lambert, Charles, Lerman, Amir, Simon, Daniel I., Vaughan, Douglas E., Lai, Dejian, Gee, Adrian P., Taylor, Doris A., Cogle, Christopher R., Thomas, James D., Olson, Rachel E., Bowman, Sherry, Francescon, Judy, Geither, Carrie, Handberg, Eileen, Kappenman, Casey, Westbrook, Lynette, Piller, Linda B., Simpson, Lara M., Baraniuk, Sarah, Loghin, Catalin, Aguilar, David, Richman, Sara, Zierold, Claudia, Spoon, Daniel B., Bettencourt, Judy, Sayre, Shelly L., Vojvodic, Rachel W., Skarlatos, Sonia I., Gordon, David J., Ebert, Ray F., Kwak, Minjung, Moyé, Lemuel A., and Simari, Robert D.

Published
2012
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69. Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure: The FOCUS-CCTRN Trial

Author

Perin, Emerson C., Willerson, James T., Pepine, Carl J., Henry, Timothy D., Ellis, Stephen G., Zhao, David X., Silva, Guilherme V., Lai, Dejian, Thomas, James D., Kronenberg, Marvin W., Martin, A. Daniel, Anderson, R. David, Traverse, Jay H., Penn, Marc S., Anwaruddin, Saif, Hatzopoulos, Antonis K., Gee, Adrian P., Taylor, Doris A., Cogle, Christopher R., Smith, Deirdre, Westbrook, Lynette, Chen, James, Handberg, Eileen, Olson, Rachel E., Geither, Carrie, Bowman, Sherry, Francescon, Judy, Baraniuk, Sarah, Piller, Linda B., Simpson, Lara M., Loghin, Catalin, Aguilar, David, Richman, Sara, Zierold, Claudia, Bettencourt, Judy, Sayre, Shelly L., Vojvodic, Rachel W., Skarlatos, Sonia I., Gordon, David J., Ebert, Ray F., Kwak, Minjung, Moyé, Lemuel A., and Simari, Robert D.

Published
2012
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70. Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial

Author

Traverse, Jay H., Henry, Timothy D., Ellis, Stephen G., Pepine, Carl J., Willerson, James T., Zhao, David X., Forder, John R., Byrne, Barry J., Hatzopoulos, Antonis K., Penn, Marc S., Perin, Emerson C., Baran, Kenneth W., Chambers, Jeffrey, Lambert, Charles, Raveendran, Ganesh, Simon, Daniel I., Vaughan, Douglas E., Simpson, Lara M., Gee, Adrian P., Taylor, Doris A., Cogle, Christopher R., Thomas, James D., Silva, Guilherme V., Jorgenson, Beth C., Olson, Rachel E., Bowman, Sherry, Francescon, Judy, Geither, Carrie, Handberg, Eileen, Smith, Deirdre X., Baraniuk, Sarah, Piller, Linda B., Loghin, Catalin, Aguilar, David, Richman, Sara, Zierold, Claudia, Bettencourt, Judy, Sayre, Shelly L., Vojvodic, Rachel W., Skarlatos, Sonia I., Gordon, David J., Ebert, Ray F., Kwak, Minjung, Moyé, Lemuel A., and Simari, Robert D.

Published
2011
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75. LateTIME: A Phase-II, Randomized, Double-Blinded, Placebo-Controlled, Pilot Trial Evaluating the Safety and Effect of Administration of Bone Marrow Mononuclear Cells 2 to 3 Weeks after Acute Myocardial Infarction

Author

Traverse, Jay H., Henry, Timothy D., Vaughan, Douglas E., Ellis, Stephen G., Pepine, Carl J., Willerson, James T., Zhao, David X.M., Simpson, Lara M., Penn, Marc S., Byrne, Barry J., Perin, Emerson C., Gee, Adrian P., Hatzopoulos, Antonis K., McKenna, David H., Forder, John R., Taylor, Doris A., Cogle, Christopher R., Baraniuk, Sarah, Olson, Rachel E., Jorgenson, Beth C., Sayre, Shelly L., Vojvodic, Rachel W., Gordon, David J., Skarlatos, Sonia I., Moyè, Lemuel A., and Simari, Robert D.

Published
2010

76. Intramyocardial injection of autologous bone marrow mononuclear cells for patients with chronic ischemic heart disease and left ventricular dysfunction (First Mononuclear Cells injected in the US [FOCUS]): Rationale and design

Author

Willerson, James T., Perin, Emerson C., Ellis, Stephen G., Pepine, Carl J., Henry, Timothy D., Zhao, David X.M., Lai, Dejian, Penn, Marc S., Byrne, Barry J., Silva, Guilherme, Gee, Adrian, Traverse, Jay H., Hatzopoulos, Antonis K., Forder, John R., Martin, Daniel, Kronenberg, Marvin, Taylor, Doris A., Cogle, Christopher R., Baraniuk, Sarah, Westbrook, Lynette, Sayre, Shelly L., Vojvodic, Rachel W., Gordon, David J., Skarlatos, Sonia I., Moyé, Lemuel A., and Simari, Robert D.

Published
2010

78. Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction

Author

Traverse, Jay H., Henry, Timothy D., Vaughn, Douglas E., Ellis, Stephen G., Pepine, Carl J., Willerson, James T., Zhao, David X.M., Piller, Linda B., Penn, Marc S., Byrne, Barry J., Perin, Emerson C., Gee, Adrian P., Hatzopoulos, Antonis K., McKenna, David H., Forder, John R., Taylor, Doris A., Cogle, Christopher R., Olson, Rachel E., Jorgenson, Beth C., Sayre, Shelly L., Vojvodic, Rachel W., Gordon, David J., Skarlatos, Sonia I., Moyeʼ, Lemuel A., and Simari, Robert D.

Published
2009

81. Macromolecular transport in the arterial intima: comparison of chronic and acute injuries

Author

Penn, Marc S., Rangaswamy, Shanthini, Saidel, Gerald M., and Chisolm, Guy M.

Subjects
Arteries -- Physiological aspects, Biological transport, Active -- Physiological aspects, Hypertension -- Physiological aspects, Biological sciences
Abstract

The intimal and concentration profiles of horseradish peroxidase (HRP) in the aorta of spontaneously a hypertensive (SHR) and Wistar-Kyoto (WK) rats were analyzed by utilizing a high-resolution technique. Analysis of HRP profiles indicated the role of the internal elastic intima (IEL) in preventing macromolecular entry into the arterial media in SHR and WK rats. Furthermore, the barrier function of IEL on macromolecular transport was not affected by endothelial cell injury.

Published
1997

89. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy

Author

Askari, Arman T, Unzek, Samuel, Popovic, Zoran B, Goldman, Corey K, Forudi, Farhad, Kiedrowski, Matthew, Rovner, Aleksandr, Ellis, Stephen G, Thomas, James D, DiCorleto, Paul E, Topol, Eric J, and Penn, Marc S

Subjects
Life Sciences (General)
Abstract

BACKGROUND: Myocardial regeneration via stem-cell mobilisation at the time of myocardial infarction is known to occur, although the mechanism for stem-cell homing to infarcted tissue subsequently and whether this approach can be used for treatment of ischaemic cardiomyopathy are unknown. We investigated these issues in a Lewis rat model (ligation of the left anterior descending artery) of ischaemic cardiomyopathy. METHODS: We studied the effects of stem-cell mobilisation by use of granulocyte colony-stimulating factor (filgrastim) with or without transplantation of syngeneic cells. Shortening fraction and myocardial strain by tissue doppler imaging were quantified by echocardiography. FINDINGS: Stem-cell mobilisation with filgrastim alone did not lead to engraftment of bone-marrow-derived cells. Stromal-cell-derived factor 1 (SDF-1), required for stem-cell homing to bone marrow, was upregulated immediately after myocardial infarction and downregulated within 7 days. 8 weeks after myocardial infarction, transplantation into the peri-infarct zone of syngeneic cardiac fibroblasts stably transfected to express SDF-1 induced homing of CD117-positive stem cells to injured myocardium after filgrastim administration (control vs SDF-1-expressing cardiac fibroblasts mean 7.2 [SD 3.4] vs 33.2 [6.0] cells/mm2, n=4 per group, p<0.02) resulting in greater left-ventricular mass (1.24 [0.29] vs 1.57 [0.27] g) and better cardiac function (shortening fraction 9.2 [4.9] vs 17.2 [4.2]%, n=8 per group, p<0.05). INTERPRETATION: These findings show that SDF-1 is sufficient to induce therapeutic stem-cell homing to injured myocardium and suggest a strategy for directed stem-cell engraftment into injured tissues. Our findings also indicate that therapeutic strategies focused on stem-cell mobilisation for regeneration of myocardial tissue must be initiated within days of myocardial infarction unless signalling for stem-cell homing is re-established.

Published
2003
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93. Association of an HDL Apolipoproteomic Score With Coronary Atherosclerosis and Cardiovascular Death

Author

Natarajan, Pradeep, primary, Collier, Tim S., additional, Jin, Zhicheng, additional, Lyass, Asya, additional, Li, Yiwei, additional, Ibrahim, Nasrien E., additional, Mukai, Renata, additional, McCarthy, Cian P., additional, Massaro, Joseph M., additional, D’Agostino, Ralph B., additional, Gaggin, Hanna K., additional, Bystrom, Cory, additional, Penn, Marc S., additional, and Januzzi, James L., additional

Published
2019
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94. Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease

Author

Jin, Zhicheng, primary, Collier, Timothy S, primary, Dai, Darlene L Y, primary, Chen, Virginia, primary, Hollander, Zsuzsanna, primary, Ng, Raymond T, primary, McManus, Bruce M, primary, Balshaw, Robert, primary, Apostolidou, Sophia, primary, Penn, Marc S, primary, and Bystrom, Cory, primary

Published
2019
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97. Lipoprotein oxidation and lipoprotein-induced cell injury in diabetes

Author

Chisolm, Guy M., Irwin, Kimberly C., and Penn, Marc S.

Subjects
Diabetes -- Physiological aspects -- Development and progression, Blood lipoproteins -- Physiological aspects, Proteolipids -- Physiological aspects, Lipoproteins -- Physiological aspects, Atherosclerosis -- Development and progression, Health, Physiological aspects, Development and progression
Abstract

There is ample evidence that oxidized lipoproteins exist in vivo, not only in atherosclerotic lesions, but also associated with some experimental models of diabetes. Whether the lipoprotein oxidation is an [...]

Published
1992

100. MP09-15 VALIDATION OF EX-VIVO MURINE BLADDER MODEL TO TEST RHOGDI-BASED BLADDER GENE THERAPIES FOR BENIGN AND MALIGNANT BLADDER PATHOLOGIES

Author

Joice, Gregory, primary, Bell, James, additional, La Favor, Justin, additional, Yoshida, Takahiro, additional, Torga, Gonzalo, additional, Harris, Kelly, additional, Liu, Xiaopu, additional, Kiedrowski, Matthew, additional, Penn, Marc, additional, Bivalacqua, Trinity, additional, and Sopko, Nikolai, additional

Published
2018
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