51. Effects of neonatal removal of superior cervical ganglion on serotonin and thyrotropin-releasing hormone immunoreactivity in the intermediolateral cell column of the rat spinal cord.
- Author
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Poulat P, Marlier L, Pellas F, Rajaofetra N, and Privat A
- Subjects
- Aging physiology, Animals, Female, Ganglia, Sympathetic cytology, Histocytochemistry, Horseradish Peroxidase, Image Processing, Computer-Assisted, Male, Rats, Serotonin immunology, Spinal Cord anatomy & histology, Spinal Cord immunology, Thyrotropin-Releasing Hormone immunology, Animals, Newborn physiology, Ganglia, Sympathetic physiology, Serotonin metabolism, Spinal Cord metabolism, Thyrotropin-Releasing Hormone metabolism
- Abstract
In this study, we investigated the effects of the neonatal removal of the right superior cervical ganglion on the serotonin-like and thyrotropin-releasing-hormone-like immunoreactivities (5-HT-LI and TRH-LI) in the intermediolateral cell column (IML) of the spinal cord by quantitative image analysis. Two weeks after the lesion, we observed a 60% reduction in 5-HT-LI, while TRH-LI was not significantly reduced, in the right IML (lesioned side) at T1-2 levels. One month after the lesion, 5-HT-LI and TRH-LI were significantly reduced by 60% in the right IML at T1-2 levels. After 3 months, this decrease persisted at this level. In addition, we observed a 30% loss of the 5-HT-LI in the right IML at T3-4 levels, whereas TRH-LI did not decrease significantly at T3-4 levels. These findings are discussed and compared with those of other experimental studies on serotonergic reorganization in the rat spinal cord.
- Published
- 1992
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