347 results on '"Pei, B."'
Search Results
52. Identification of Two-Phase Flow Patterns in a Nuclear Reactor by High-Frequency Contribution Fraction
- Author
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Wang, Y. W., primary, Pei, B. S., additional, King, C. H., additional, and Lee, S. C., additional
- Published
- 1990
- Full Text
- View/download PDF
53. Authors
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Gilbert, E. Robert, primary, Bailey, Wendell J., additional, Johnson, A. Burtron, additional, McKinnon, Mikal A., additional, Takahashi, Tadao, additional, Yamaguchi, Osamu, additional, Kobori, Tetsuo, additional, Sloan, Sandra M., additional, Hassan, Yassin A., additional, Kobayashi, Tsuguyuki, additional, Kinoshita, Motoyasu, additional, Hattori, Sadao, additional, Ogawa, Toru, additional, Tsuboi, Yasushi, additional, Ishida, Masayoshi, additional, Ogawa, Shinta, additional, Saito, Hiroaki, additional, Yamamoto, Masao, additional, Matsumoto, Ken-ichi, additional, Goles, Ronald W., additional, Hof, Peter J., additional, Dierks, Richard D., additional, Holton, Langdon K., additional, Wang, Y. W., additional, Pei, B. S., additional, King, C. H., additional, Lee, S. C., additional, Salim, Tanvir, additional, Yeung, Woon-Shing, additional, Fernandez, R. Thomas, additional, Parks, Geoffrey Thomas, additional, Gould, Robert, additional, Kenney, Edward S., additional, Levine, Samuel H., additional, Flinchbaugh, Terry L., additional, Penkala, John L., additional, Hughes, Daniel E., additional, Rudy, Kenneth E., additional, Faust, Craig C., additional, and Maag, Ronald H., additional
- Published
- 1990
- Full Text
- View/download PDF
54. Separation and Mineralogical Analysis of Bayer Red Mud.
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Picaro, T., Pei, B., Kane, A.R., Thornber, M.R., and Fletcher, A.B.
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- 2002
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55. Oxidation mechanism of Si3N4-bonded SiC ceramics by CO, CO2 and steam
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Wang, G. X., Gaoqing (Max) Lu, Pei, B., and Yu, A. B.
56. Reply to comments on 'Oxidation mechanism of Si3N4-bonded SiC ceramics by CO, CO2 and steam,' by Balat et al
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Wang, G. X., Gaoqing (Max) Lu, Pei, B., and Yu, A. B.
57. Glass Pyramid in the Cour Napoléon of the Musée du Louvre
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I. M. Pei (b. 1917) and I. M. Pei (b. 1917)
- Abstract
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58. Authors
- Author
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Galperin, Alex, primary, Segev, Meir, additional, Radkowsky, Alvin, additional, Pei, B. S., additional, Chen, Y. B., additional, Shih, Chunkuan, additional, Lin, W. S., additional, Hida, Kazuki, additional, Kusuno, Sadao, additional, Seino, Takeshi, additional, Geldard, John F., additional, Beyerlein, Adolph L., additional, Chiu, Houn-Lin, additional, McGrail, B. P., additional, Matsuda, Masami, additional, Funabashi, Kiyomi, additional, Nishi, Takashi, additional, Yusa, Hideo, additional, Kikuchi, Makoto, additional, Rao, P. Bhaskar, additional, Singh, Om Pal, additional, Sohal, Manohar S., additional, Lee, Jae Young, additional, No, Hee Cheon, additional, Uda, Tatsuhiko, additional, Otsuka, Hisao, additional, Ozawa, Yoshihiro, additional, Sulima, Romuald, additional, Clayton, Eugene D., additional, Clark, Hugh K., additional, Walker, Gordon, additional, and Libby, Richard A., additional
- Published
- 1986
- Full Text
- View/download PDF
59. Identification of Two-Phase Flow Patterns by a Single Void Fraction Sensor
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Wang, Y. W., primary, King, C. H., additional, and Pei, B. S., additional
- Published
- 1988
- Full Text
- View/download PDF
60. Authors
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Behbahani, Alireza, primary, Reagan, Jeffery, additional, Nakada, Kotaro, additional, Miyagi, Kazumi, additional, Handa, Norihiko, additional, Hattori, Sadao, additional, Kataoka, Yoshiyuki, additional, Suzuki, Hiroaki, additional, Murase, Michio, additional, Sumida, Isao, additional, Horiuchi, Tetsuo, additional, Miki, Minoru, additional, Lucas, Michel, additional, Erdmann, R. C., additional, Sun, Bill K-H., additional, Hesse, Ulrich, additional, Saltos, Nicholas T., additional, Aldemir, Tunc, additional, Christensen, Richard N., additional, King, C. H., additional, Ouyang, M. S., additional, Pei, B. S., additional, Wang, Y. W., additional, Rathore, R. K. S., additional, Munshi, P., additional, Jarwal, R. K., additional, and Dhariyal, I. D., additional
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- 1988
- Full Text
- View/download PDF
61. Identification of Two-Phase Flow Regimes by Neutron Noise Analysis
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King, C. H., primary, Ouyang, M. S., additional, Pei, B. S., additional, and Lee, S. C., additional
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- 1989
- Full Text
- View/download PDF
62. Authors
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Takahashi, Noriaki, primary, Morishita, Hideaki, additional, Kanegae, Naomichi, additional, Niimi, Akihiro, additional, Carew, John F., additional, Berglund, Robert C., additional, Tippets, Frank E., additional, Salerno, Leroy N., additional, Yuan, Liq-Ji, additional, Weng, Pao-Shan, additional, Chan, Cheng-Chang, additional, Kim, Tae Woon, additional, Han, Sang Hoon, additional, Yoo, Kun Joong, additional, Mosteller, Russell D., additional, Jensen, Peter J., additional, Anderson, Michael J., additional, Eisenhart, Laurance D., additional, Abdollahian, Rana, additional, Chao, Jason, additional, Eich, Walter J., additional, Kawashima, Katsuyuki, additional, Karam, Ratib A., additional, Faubel, Werner, additional, Ali, Sameh A., additional, Saad, Elie, additional, Laberge, Normand Laurent, additional, Feng, Xiangdong, additional, King, C. H., additional, Ouyang, M. S., additional, Pei, B. S., additional, Lee, S. C., additional, Schmittroth, Frank, additional, Myjak, Miriam A., additional, Shahub, A. M., additional, and Williams, M. M. R., additional
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- 1989
- Full Text
- View/download PDF
63. Identification of Two-Phase Flow Regimes by an Optimum Modeling Method
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King, C. H., primary, Ouyang, M. S., additional, Pei, B. S., additional, and Wang, Y. W., additional
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- 1988
- Full Text
- View/download PDF
64. Authors
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Wang, Tien-Ko, primary, Chang, Szu-Li, additional, Teng, Shi-Ping, additional, Jokiniemi, Jorma, additional, Sakurai, Tsutomu, additional, Takahashi, Akira, additional, Ishikawa, Niro, additional, Komaki, Yoshihide, additional, Comes, Scott A., additional, Turinsky, Paul J., additional, Wieczorek, Herbert, additional, Oser, Bernhard, additional, Wang, Y. W., additional, King, C. H., additional, Pei, B. S., additional, Kolev, Nikolay Ivanov, additional, Sami, S. M., additional, Kraitem, M., additional, Saltos, Nicholas T., additional, Christensen, Richard N., additional, and Aldemir, Tunc, additional
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- 1988
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65. Evaluations and Modifications of the EPRI-1 Correlation on PWR Critical Heat Flux Predictions Under Normal and Abnormal Fuel Conditions
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Pei, B. S., primary, Chen, Y. B., additional, Shih, Chunkuan, additional, and Lin, W. S., additional
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- 1986
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66. A dynamic system regulation measure for increasing effective capacity: the X-factor theory
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Delp, D., primary, Si, J., additional, Hwang, Y., additional, and Pei, B., additional
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67. Oxadisilole Groups as a Benzyne Precursor and a Route to Triptycenes.
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Pei, B.-J., Chan, W.-H., and Lee, A.W.
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- 2011
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68. Aza-Michael Addition Catalyzed by Camphorsulfonyl Hydrazines.
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Chen, L.-Y, He, H., Pei, B.-J., Chan, W.-H., and Lee, A.W.
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- 2009
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- View/download PDF
69. 3D Alchemy: a guide to 3D realistic computer graphics
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Han, Ching-Pei B.
- Subjects
- 3D animation
- Abstract
Last year, many films and commercials took advantage of computer technology to create astonishing 3D animations. Examples such as the Listerine commercial series, the NBA logo on TV, and the Chip & Pepper TV cartoon, featured unique and vibrant computer images. Among the various animations, some were made by high end computer systems, but some simply by personal computers. Small, fast, and more capable personal computers are now performing professional-level video production roles and, in fact, they are a staple of many feature film productions and broadcast television facilities.
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- 1993
70. A Thermodynamic Assessment of the Iron - Antimony System
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Pei, B., Bjoerkman, B., Sundman, B., and Jansson, B.
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- 1995
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71. Establishment of thermal margin-CPR calculating methodology for BWR
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Wang, S. F., Pei, B. S., and Jan, J. A.
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- 1990
72. The development and assessment of CHF correlations for rod bundles
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Lee, C. H., Pei, B. S., Lin, W. S., and Shih, C.
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- 1989
73. Identification of two-phase flow regimes by neutron noise analysis
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King, C. H., Pei, B. S., and Ouyang, M. S.
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- 1988
74. Steady-state transition boiling heat fluxes measurements and analysis in a freon-113 system
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Pei, B. S. and Woong, N. T.
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- 1986
75. Boiling heat transfer studies by using hot ball quenching
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Pei, B.-S., Lian, H. S., Shih, C. K., and Yin, S. T.
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- 1986
76. Transition boiling heat transfer studies by using hot cylinder quenching method
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Lee, R. Y. and Pei, B. S.
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- 1986
77. The evaluations of the effects of three fuel elements CHF abnormalities on the EPRI-1 correlation
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Lin, W. S., Chen, Y. B., Pei, B. S., and Shih, Chun-Kuan
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- 1986
78. RETRAN-02 small break LOCA analysis of Chinshan nuclear power plant--on turbine trip without bypass causing stuck open relief valve
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Chou, H. P., Chieng, C. C., Yu, G. P., and Pei, B. S.
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- 1986
79. The evaluations and modifications of the EPRI-1 correlation for CHF predictions on PWR normal fuel conditions
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Lin, W. S., Shih, C. K., Chen', Y. B., and Pei, B. S.
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- 1986
80. RETRAN-02 small break LOCA analysis on Chinshan unit I's HPCI steam supply line 0.1 ft{sup}2 break
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Yu, G. P., Chieng, C. C., Chou, H. P., and Pei, B. S.
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- 1986
81. An integrated encyclopedia of DNA elements in the human genome
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Robert Altshuler, Laura Elnitski, Michael Anaya, Alec Victorsen, Deborah Winter, Javier Herrero, Katherine Varley, Andrea Sboner, Oscar Junhong Luo, Marco Mariotti, Cristina Sisu, Mike Kay, Timothy Dreszer, Jane Loveland, Alexandra Bignell, Ewan Birney, Tim @timjph Hubbard, Kuljeet Sandhu, Eric Haugen, Chris Gunter, Alexej Abyzov, Lucas Ward, Georgi Marinov, Michael Pazin, Thomas Gingeras, Alexander Dobin, Kimberly Foss, Xianjun Dong, Benoit Miotto, Piotr Mieczkowski, Cedric Notredame, Andrew Berry, Shawn Gillespie, Axel Visel, Shawn Levy, Richard Sandstrom, Jose M Gonzalez, Melissa Fullwood, Timo Lassmann, Michael Tress, Julien Lagarde, Kevin Yip, Leslie Adams, Sylvain Foissac, Bronwen Aken, Piero Carninci, Suganthi Balasubramanian, Andrea Tanzer, Sarah Djebali, Michael Hoffman, Gloria Despacio-Reyes, Peter Park, Felix Kokocinski, Katherine Fisher-Aylor, Juan M Vaquerizas, Peggy Farnham, Patrick Collins, Amonida Zadissa, Pedro Ferreira, Philippe Batut, Michael Snyder, Electra Tapanari, Adam Frankish, Paul Flicek, AMARTYA SANYAL, Tyler Alioto, Giovanni Bussotti, Laurence Meyer, Jingyi Jessica Li, Matthew Blow, Tristan FRUM, Roger Alexander, Rory Johnson, Charles Steward, Meizhen Zheng, Margus Lukk, Ross Hardison, Claire Davidson, Gary Saunders, Alan Boyle, Luiz Penalva, Rajinder Kaul, Lazaro Centanin, Florencia Pauli Behn, Thomas Derrien, Nathan Sheffield, Toby Hunt, Eric Nguyen, Jeff Vierstra, Konrad Karczewski, Kimberly Bell, Yanbao Yu, Hagen U Tilgner, James Taylor, Balázs Bánfai, Catherine Snow, Benjamin Vernot, Stephan Kirchmaier, Michael Sammeth, Steven Wilder, Angelika Merkel, Joanna Mieczkowska, Guoliang Li, Wei Lin, Jennifer Harrow, Thomas Oliver Auer, Daniel Barrell, Eddie Park, Alvis Brazma, Hazuki Takahashi, Nathan Johnson, Daniel Sobral, Terry Furey, Alexandre Reymond, Jonathan Mudge, Anshul Kundaje, Jose Rodriguez, Akshay Bhinge, James Gilbert, Jakub Karczewski, Venkat Malladi, Troy Whitfield, Orion Buske, Ian Dunham, Jennifer Moran, Joachim Wittbrodt, Charles B. Epstein, Laurens Wilming, Jason Gertz, Joshua Akey, Joel Rozowsky, Laboratoire de Génétique Cellulaire (LGC), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), National Human Genome Research Institute (NHGRI), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Antonarakis, Stylianos, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Altshuler, Robert Charles, Ernst, Jason, Kellis, Manolis, Kheradpour, Pouya, Ward, Lucas D., Eaton, Matthew Lucas, Hendrix, David A., Jungreis, Irwin, Lin, Michael F., Washietl, Stefan, Lists of participants and their affiliations appear at the end of the paper and in the 'Collaboration/Projet' field., The Consortium is funded by grants from the NHGRI as follows: production grants: U54HG004570 (B. E. Bernstein), U01HG004695 (E. Birney), U54HG004563 (G. E. Crawford), U54HG004557 (T. R. Gingeras), U54HG004555 (T. J. Hubbard), U41HG004568 (W. J. Kent), U54HG004576 (R. M. Myers), U54HG004558 (M. Snyder), U54HG004592 (J. A. Stamatoyannopoulos). Pilot grants: R01HG003143 (J. Dekker), RC2HG005591 and R01HG003700 (M. C. Giddings), R01HG004456-03 (Y. Ruan), U01HG004571 (S. A. Tenenbaum), U01HG004561 (Z. Weng), RC2HG005679 (K. P. White). This project was supported in part by American Recovery and Reinvestment Act (ARRA) funds from the NHGRI through grants U54HG004570, U54HG004563, U41HG004568, U54HG004592, R01HG003143, RC2HG005591, R01HG003541,U01HG004561,RC2HG005679andR01HG003988(L. Pennacchio). In addition, work from NHGRI Groups was supported by the Intramural Research Program of the NHGRI (L. Elnitski, ZIAHG200323, E. H. Margulies, ZIAHG200341). Research in the Pennachio laboratory was performed at Lawrence Berkeley National Laboratory and at the United States Department of Energy Joint Genome Institute, Department of Energy Contract DE-AC02-05CH11231, University of California., Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, Epstein CB, Frietze S, Harrow J, Kaul R, Khatun J, Lajoie BR, Landt SG, Lee BK, Pauli F, Rosenbloom KR, Sabo P, Safi A, Sanyal A, Shoresh N, Simon JM, Song L, Trinklein ND, Altshuler RC, Birney E, Brown JB, Cheng C, Djebali S, Dong X, Dunham I, Ernst J, Furey TS, Gerstein M, Giardine B, Greven M, Hardison RC, Harris RS, Herrero J, Hoffman MM, Iyer S, Kellis M, Khatun J, Kheradpour P, Kundaje A, Lassmann T, Li Q, Lin X, Marinov GK, Merkel A, Mortazavi A, Parker SC, Reddy TE, Rozowsky J, Schlesinger F, Thurman RE, Wang J, Ward LD, Whitfield TW, Wilder SP, Wu W, Xi HS, Yip KY, Zhuang J, Pazin MJ, Lowdon RF, Dillon LA, Adams LB, Kelly CJ, Zhang J, Wexler JR, Green ED, Good PJ, Feingold EA, Bernstein BE, Birney E, Crawford GE, Dekker J, Elnitski L, Farnham PJ, Gerstein M, Giddings MC, Gingeras TR, Green ED, Guigó R, Hardison RC, Hubbard TJ, Kellis M, Kent W, Lieb JD, Margulies EH, Myers RM, Snyder M, Stamatoyannopoulos JA, Tenenbaum SA, Weng Z, White KP, Wold B, Khatun J, Yu Y, Wrobel J, Risk BA, Gunawardena HP, Kuiper HC, Maier CW, Xie L, Chen X, Giddings MC, Bernstein BE, Epstein CB, Shoresh N, Ernst J, Kheradpour P, Mikkelsen TS, Gillespie S, Goren A, Ram O, Zhang X, Wang L, Issner R, Coyne MJ, Durham T, Ku M, Truong T, Ward LD, Altshuler RC, Eaton ML, Kellis M, Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, Xue C, Marinov GK, Khatun J, Williams BA, Zaleski C, Rozowsky J, Röder M, Kokocinski F, Abdelhamid RF, Alioto T, Antoshechkin I, Baer MT, Batut P, Bell I, Bell K, Chakrabortty S, Chen X, Chrast J, Curado J, Derrien T, Drenkow J, Dumais E, Dumais J, Duttagupta R, Fastuca M, Fejes-Toth K, Ferreira P, Foissac S, Fullwood MJ, Gao H, Gonzalez D, Gordon A, Gunawardena HP, Howald C, Jha S, Johnson R, Kapranov P, King B, Kingswood C, Li G, Luo OJ, Park E, Preall JB, Presaud K, Ribeca P, Risk BA, Robyr D, Ruan X, Sammeth M, Sandhu KS, Schaeffer L, See LH, Shahab A, Skancke J, Suzuki AM, Takahashi H, Tilgner H, Trout D, Walters N, Wang H, Wrobel J, Yu Y, Hayashizaki Y, Harrow J, Gerstein M, Hubbard TJ, Reymond A, Antonarakis SE, Hannon GJ, Giddings MC, Ruan Y, Wold B, Carninci P, Guigó R, Gingeras TR, Rosenbloom KR, Sloan CA, Learned K, Malladi VS, Wong MC, Barber GP, Cline MS, Dreszer TR, Heitner SG, Karolchik D, Kent W, Kirkup VM, Meyer LR, Long JC, Maddren M, Raney BJ, Furey TS, Song L, Grasfeder LL, Giresi PG, Lee BK, Battenhouse A, Sheffield NC, Simon JM, Showers KA, Safi A, London D, Bhinge AA, Shestak C, Schaner MR, Kim SK, Zhang ZZ, Mieczkowski PA, Mieczkowska JO, Liu Z, McDaniell RM, Ni Y, Rashid NU, Kim MJ, Adar S, Zhang Z, Wang T, Winter D, Keefe D, Birney E, Iyer VR, Lieb JD, Crawford GE, Li G, Sandhu KS, Zheng M, Wang P, Luo OJ, Shahab A, Fullwood MJ, Ruan X, Ruan Y, Myers RM, Pauli F, Williams BA, Gertz J, Marinov GK, Reddy TE, Vielmetter J, Partridge E, Trout D, Varley KE, Gasper C, Bansal A, Pepke S, Jain P, Amrhein H, Bowling KM, Anaya M, Cross MK, King B, Muratet MA, Antoshechkin I, Newberry KM, McCue K, Nesmith AS, Fisher-Aylor KI, Pusey B, DeSalvo G, Parker SL, Balasubramanian S, Davis NS, Meadows SK, Eggleston T, Gunter C, Newberry J, Levy SE, Absher DM, Mortazavi A, Wong WH, Wold B, Blow MJ, Visel A, Pennachio LA, Elnitski L, Margulies EH, Parker SC, Petrykowska HM, Abyzov A, Aken B, Barrell D, Barson G, Berry A, Bignell A, Boychenko V, Bussotti G, Chrast J, Davidson C, Derrien T, Despacio-Reyes G, Diekhans M, Ezkurdia I, Frankish A, Gilbert J, Gonzalez JM, Griffiths E, Harte R, Hendrix DA, Howald C, Hunt T, Jungreis I, Kay M, Khurana E, Kokocinski F, Leng J, Lin MF, Loveland J, Lu Z, Manthravadi D, Mariotti M, Mudge J, Mukherjee G, Notredame C, Pei B, Rodriguez JM, Saunders G, Sboner A, Searle S, Sisu C, Snow C, Steward C, Tanzer A, Tapanari E, Tress ML, van Baren MJ, Walters N, Washietl S, Wilming L, Zadissa A, Zhang Z, Brent M, Haussler D, Kellis M, Valencia A, Gerstein M, Reymond A, Guigó R, Harrow J, Hubbard TJ, Landt SG, Frietze S, Abyzov A, Addleman N, Alexander RP, Auerbach RK, Balasubramanian S, Bettinger K, Bhardwaj N, Boyle AP, Cao AR, Cayting P, Charos A, Cheng Y, Cheng C, Eastman C, Euskirchen G, Fleming JD, Grubert F, Habegger L, Hariharan M, Harmanci A, Iyengar S, Jin VX, Karczewski KJ, Kasowski M, Lacroute P, Lam H, Lamarre-Vincent N, Leng J, Lian J, Lindahl-Allen M, Min R, Miotto B, Monahan H, Moqtaderi Z, Mu XJ, O'Geen H, Ouyang Z, Patacsil D, Pei B, Raha D, Ramirez L, Reed B, Rozowsky J, Sboner A, Shi M, Sisu C, Slifer T, Witt H, Wu L, Xu X, Yan KK, Yang X, Yip KY, Zhang Z, Struhl K, Weissman SM, Gerstein M, Farnham PJ, Snyder M, Tenenbaum SA, Penalva LO, Doyle F, Karmakar S, Landt SG, Bhanvadia RR, Choudhury A, Domanus M, Ma L, Moran J, Patacsil D, Slifer T, Victorsen A, Yang X, Snyder M, Auer T, Centanin L, Eichenlaub M, Gruhl F, Heermann S, Hoeckendorf B, Inoue D, Kellner T, Kirchmaier S, Mueller C, Reinhardt R, Schertel L, Schneider S, Sinn R, Wittbrodt B, Wittbrodt J, Weng Z, Whitfield TW, Wang J, Collins PJ, Aldred SF, Trinklein ND, Partridge EC, Myers RM, Dekker J, Jain G, Lajoie BR, Sanyal A, Balasundaram G, Bates DL, Byron R, Canfield TK, Diegel MJ, Dunn D, Ebersol AK, Frum T, Garg K, Gist E, Hansen R, Boatman L, Haugen E, Humbert R, Jain G, Johnson AK, Johnson EM, Kutyavin TV, Lajoie BR, Lee K, Lotakis D, Maurano MT, Neph SJ, Neri FV, Nguyen ED, Qu H, Reynolds AP, Roach V, Rynes E, Sabo P, Sanchez ME, Sandstrom RS, Sanyal A, Shafer AO, Stergachis AB, Thomas S, Thurman RE, Vernot B, Vierstra J, Vong S, Wang H, Weaver MA, Yan Y, Zhang M, Akey JM, Bender M, Dorschner MO, Groudine M, MacCoss MJ, Navas P, Stamatoyannopoulos G, Kaul R, Dekker J, Stamatoyannopoulos JA, Dunham I, Beal K, Brazma A, Flicek P, Herrero J, Johnson N, Keefe D, Lukk M, Luscombe NM, Sobral D, Vaquerizas JM, Wilder SP, Batzoglou S, Sidow A, Hussami N, Kyriazopoulou-Panagiotopoulou S, Libbrecht MW, Schaub MA, Kundaje A, Hardison RC, Miller W, Giardine B, Harris RS, Wu W, Bickel PJ, Banfai B, Boley NP, Brown JB, Huang H, Li Q, Li JJ, Noble WS, Bilmes JA, Buske OJ, Hoffman MM, Sahu AD, Kharchenko PV, Park PJ, Baker D, Taylor J, Weng Z, Iyer S, Dong X, Greven M, Lin X, Wang J, Xi HS, Zhuang J, Gerstein M, Alexander RP, Balasubramanian S, Cheng C, Harmanci A, Lochovsky L, Min R, Mu XJ, Rozowsky J, Yan KK, Yip KY, Birney E., and Miotto, Benoit
- Subjects
Encyclopedias as Topic ,[SDV]Life Sciences [q-bio] ,DNA Footprinting ,Genoma humà ,Binding Sites/genetics ,Histones/chemistry/metabolism ,0302 clinical medicine ,Exons/genetics ,ddc:576.5 ,0303 health sciences ,Multidisciplinary ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,[SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,DNA-Binding Proteins/metabolism ,region ,Chemistry ,Genetic Predisposition to Disease/genetics ,Genomics ,Polymorphism, Single Nucleotide/genetics ,[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,Neoplasms/genetics ,Chromatin ,Cell biology ,in vivo ,Genetic Variation/genetics ,030220 oncology & carcinogenesis ,Deoxyribonuclease I/metabolism ,Proteins/genetics ,transcription factor-binding ,chromosome conformation capture ,DNA Methylation/genetics ,Chromosomes, Human/genetics/metabolism ,Chromatin Immunoprecipitation ,Mammals/genetics ,DNA/genetics ,determinant ,Article ,03 medical and health sciences ,map ,Animals ,Humans ,Transcription Factors/metabolism ,Alleles ,mouse ,030304 developmental biology ,Transcription, Genetic/genetics ,Chromatin/genetics/metabolism ,Sequence Analysis, RNA ,human cell ,Molecular Sequence Annotation ,Regulatory Sequences, Nucleic Acid/genetics ,Promoter Regions, Genetic/genetics ,DNA binding site ,Genòmica ,Genome, Human/genetics ,chromatin ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Genètica ,Genome-Wide Association Study - Abstract
The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence variants linked to human disease, and can thereby guide interpretation of this variation. Overall, the project provides new insights into the organization and regulation of our genes and genome, and is an expansive resource of functional annotations for biomedical research. The Consortium is funded by grants from the NHGRI as follows: production grants: U54HG004570 (B. E. Bernstein); U01HG004695 (E. Birney); U54HG004563 (G. E. Crawford); U54HG004557 (T. R. Gingeras); U54HG004555 (T. J. Hubbard); U41HG004568 /n(W. J. Kent); U54HG004576 (R. M. Myers); U54HG004558 (M. Snyder);/nU54HG004592 (J. A. Stamatoyannopoulos). Pilot grants: R01HG003143 (J. Dekker); RC2HG005591 and R01HG003700 (M. C. Giddings); R01HG004456-03 (Y. Ruan); U01HG004571 (S. A. Tenenbaum); U01HG004561 (Z. Weng); RC2HG005679 (K. P. White). This project was supported in part by American Recovery and/nReinvestment Act (ARRA) funds from the NHGRI through grants U54HG004570, U54HG004563, U41HG004568, U54HG004592, R01HG003143, RC2HG005591,R01HG003541, U01HG004561, RC2HG005679andR01HG003988(L. Pennacchio). In addition, work from NHGRI Groups was supported by the Intramural Research/nProgram of the NHGRI (L. Elnitski, ZIAHG200323; E. H. Margulies, ZIAHG200341). Research in the Pennachio laboratory was performed at Lawrence Berkeley National Laboratory and at the United States Department of Energy Joint Genome Institute, Department of Energy Contract DE-AC02-05CH11231, University of California.
- Published
- 2012
82. A model for sound velocity and its relationship with interfacial area in a steam-water, two-phase bubbly flow
- Author
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Pei, B [National Tsing Hua Univ., Hsinchu (Taiwan, Province of China). Dept. of Nuclear Engineering]
- Published
- 1992
83. Identification of two-phase flow regimes by time-series modeling
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Pei, B
- Published
- 1987
84. Nuclear safety research at National Tsing-Hua University
- Author
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Pei, B
- Published
- 1987
85. Identification of two-phase flow patterns by a single void fraction sensor
- Author
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Pei, B
- Published
- 1988
86. Prediction of critical heat flux in flow boiling at low qualities
- Author
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Pei, B
- Published
- 1981
87. Cations-Pillared and Polyaniline-Encapsulated Vanadate Cathode for High-Performance Aqueous Zinc-Ion Batteries.
- Author
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Ni M, Qin M, Chang H, Shi X, Pei B, Liang S, and Cao X
- Abstract
Layered vanadium-based oxides have emerged as highly promising candidates for aqueous zinc-ion batteries (AZIBs) due to their open-framework layer structure and high theoretical capacity among the diverse cathode materials investigated. However, the susceptibility to structural collapse during charge-discharge cycling severely hampers their advancement. Herein, we propose an effective strategy to enhance the cycling stability of vanadium oxides. Initially, the structural integrity of the host material is significantly reinforced by incorporating bi-cations Na
+ and NH4 + as "pillars" between the V2 O5 layers (NaNVO). Subsequently, surface coating with polyaniline (PA) is employed to further improve the conductivity of the active material. As anticipated, the assembled Zn//NaNVO@PA cell exhibits a remarkable discharge capacity of 492 mAh g-1 at 0.1 A g-1 and exceptional capacity retention up to 89.2 % after 1000 cycles at a current density of 5 A g-1 . Moreover, a series of in-situ and ex-situ characterization techniques were utilized to investigate both Zn ions insertion/extraction storage mechanism and the contribution of polyaniline protonation process towards enhancing capacity., (© 2024 Wiley-VCH GmbH.)- Published
- 2024
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88. SOX17 orchestrates immune evasion in early colorectal adenomas and cancers.
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Pei B, Yang H, and Zhou F
- Subjects
- Humans, Animals, Tumor Escape, Mice, Colorectal Neoplasms immunology, Adenoma immunology, SOXF Transcription Factors metabolism
- Published
- 2024
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89. Neutrophil-to-lymphocyte ratio as a predictive biomarker for hyperprogressive disease mediated by immune checkpoint inhibitors: a systematic review and meta-analysis.
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Pei B, Zhang J, Lai L, and Chen H
- Subjects
- Humans, Disease Progression, Biomarkers, Tumor blood, Lymphocyte Count, Biomarkers, Prognosis, Neutrophils immunology, Immune Checkpoint Inhibitors therapeutic use, Lymphocytes immunology, Neoplasms drug therapy, Neoplasms immunology, Neoplasms blood
- Abstract
Background: Hyperprogressive disease (HPD) is a novel pattern of paradoxically rapid tumor progression, which often leads to early death, mostly in the first 2 months of treatment with immune checkpoint inhibitors (ICIs). Currently, there is no validated biomarker to assess patients at risk of HPD., Aim: The aim of this study was to systematically evaluate the predictive value of the neutrophil-to-lymphocyte ratio (NLR) in HPD and establish a reliable variable to support clinicians in defining personalized treatment strategies., Methods: PubMed, Embase, Web of Science, Scopus, and Cochrane Library databases were searched for studies published before 31 December 2023. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of eligible studies. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects or a fixed-effects model to evaluate the association between the NLR and the risk of HPD., Results: A total of 17 studies with 2,964 patients were included for meta-analysis. The incidence of HPD across different types of tumors ranged from 6.3% to 35.6%. In the pooled analysis of the NLR and HPD, we identified that the NLR significantly associated with the risk of HPD (OR = 0.65; 95% CI: 0.46 to 0.91; p = 0.01) ( I
2 = 52%, p = 0.007)., Conclusion: In the future, the NLR may serve as a remarkable biomarker for predicting the risk of HPD in clinical practice., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Pei, Zhang, Lai and Chen.)- Published
- 2024
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90. A New Method for Scoliosis Screening Incorporating Deep Learning With Back Images.
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Zhang L, Pei B, Zhang S, Lu D, Xu Y, Huang X, and Wu X
- Abstract
Study Design: Retrospective observational study., Objectives: Scoliosis is commonly observed in adolescents, with a world0wide prevalence of 0.5%. It is prone to be overlooked by parents during its early stages, as it often lacks overt characteristics. As a result, many individuals are not aware that they may have scoliosis until the symptoms become quite severe, significantly affecting the physical and mental well-being of patients. Traditional screening methods for scoliosis demand significant physician effort and require unnecessary radiography exposure; thus, implementing large-scale screening is challenging. The application of deep learning algorithms has the potential to reduce unnecessary radiation risks as well as the costs of scoliosis screening., Methods: The data of 247 scoliosis patients observed between 2008 and 2021 were used for training. The dataset included frontal, lateral, and back upright images as well as X-ray images obtained during the same period. We proposed and validated deep learning algorithms for automated scoliosis screening using upright back images. The overall process involved the localization of the back region of interest (ROI), spinal region segmentation, and Cobb angle measurements., Results: The results indicated that the accuracy of the Cobb angle measurement was superior to that of the traditional human visual recognition method, providing a concise and convenient scoliosis screening capability without causing any harm to the human body., Conclusions: The method was automated, accurate, concise, and convenient. It is potentially applicable to a wide range of screening methods for the detection of early scoliosis., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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91. Current research and future prospects of immunonutrition in gastrointestinal malignancies.
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Ma X, Pei B, Wu N, Wang C, Yu Y, and Yang W
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- Humans, Nutritional Support methods, Animals, Fatty Acids, Omega-3 therapeutic use, Fatty Acids, Omega-3 administration & dosage, Dietary Supplements, Glutamine therapeutic use, Immunonutrition Diet, Gastrointestinal Neoplasms immunology, Gastrointestinal Neoplasms therapy
- Abstract
Immune nutrition, as an integral component of nutritional support therapy, has garnered significant attention and research in the treatment of gastrointestinal malignancies. Recent advancements in nutritional formulas containing components such as glutamine, omega-3 polyunsaturated fatty acids, and arginine have led to the development of what is now termed immune nutrition or pharmacological nutrition. These formulations go beyond traditional nutritional support, functioning more like nutritional supplements with pharmacological effects. Patients with gastrointestinal malignancies often experience malnutrition and metabolic disturbances, resulting in immune dysfunction, cytokine dysregulation, and endocrine abnormalities. These issues can compromise intestinal mucosal barrier function, affecting the efficacy and prognosis of anticancer therapies. Recent studies indicate that immune nutrition can modulate specific mechanisms involved in various immune and inflammatory pathways, thereby improving patients' immune status and treatment outcomes. While optimal patient selection, dosing, and timing of immune nutrition are still under investigation, its potential applications in oncology are promising. This article aims to analyze the existing evidence regarding the therapeutic benefits of immune nutrition in gastrointestinal malignancies, offering insights into its clinical standardization and application., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Ma, Pei, Wu, Wang, Yu and Yang.)
- Published
- 2024
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92. [Effect analysis of trimethylamine N-oxide and its precursors on susceptibility to pancreatic diseases].
- Author
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Liu J, Luo X, Pei B, Ge P, Ma S, Luo Y, and Chen H
- Subjects
- Humans, Pancreatitis diagnosis, Pancreatic Neoplasms, Methylamines blood, Betaine, Choline, Carnitine, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Mendelian Randomization Analysis, Pancreatic Diseases diagnosis
- Abstract
Objective: To investigate the causal relationship between trimethylamine N-oxide (TMAO) and its precursors (betaine, carnitine, and choline) and pancreatic diseases based on the Mendelian randomization (MR) method., Methods: Genome-wide association study data of TMAO, betaine, carnitine, choline, acute pancreatitis (AP), chronic pancreatitis (CP), pancreatic cancer (PC), and circulating immune cell characteristics (white blood cell, lymphocyte, monocyte, neutrophil, eosinophil and basophil) were collected. According to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)-MR reporting guidelines, the available genetic variants [single nucleotide polymorphism (SNP)] were strictly screened. The causal relationship between exposure (TMAO and its precursors) and outcomes (pancreatic diseases and circulating immune cell characteristics) was evaluated using inverse variance weighting (IVW), MR-Egger regression and weighted median. The reliability of the results was evaluated by sensitivity analysis based on MR-Egger regression, MR-PRESSO, Cochrane's Q test and leave-one-out method., Results: A total of 36 SNP associated with TMAO and its precursors were included. Five of these were associated with TMAO, 13 with betaine, 12 with carnitine, and 6 with choline. (1) MR analysis showed that TMAO may increase the risk of AP [odds ratio (OR) = 1.100, 95% confidence interval (95%CI) was 1.008-1.200, P = 0.032], and choline may reduce the risk of alcoholic acute pancreatitis (AAP; OR = 0.743, 95%CI was 0.585-0.944, P = 0.015). The analysis results of MR-Egger regression and weighted median were consistent with the IVW results. There is no evidence to support a causal relationship between TMAO and its precursors and the risk of CP and PC. Sensitivity analysis indicated that SNP analyzed by MR showed no heterogeneity and low pleiotropy. The leave-one-out method analysis determined that after excluding any SNP, the effect intervals of the remaining SNP on the results were similar to the overall effect intervals, which suggested the robustness of MR results. (2) There was a positive causal relationship between plasma TMAO level and circulating monocyte count (OR = 1.017, 95%CI was 1.000*-1.034, P = 0.048, * represented that the data was obtained by correcting to 3 decimal places from 1.000 1). The causal effect obtained by MR-Egger regression and weighted median analysis was consistent with the results of IVW. Sensitivity analysis illustrated SNP analyzed by MR showed no heterogeneity and pleiotropy. The leave-one-out method analysis determined that after excluding any SNP, the effect intervals of the remaining SNP on the results were similar to the overall effect intervals, which suggested the robustness of MR results., Conclusions: TMAO and choline may change the risk of AP, and TMAO may contribute to the increase of circulating monocyte count in AP.
- Published
- 2024
- Full Text
- View/download PDF
93. From Natural Fibers to High-Performance Anodes: Sisal Hemp Derived Hard Carbon for Na-/K-Ion Batteries and Mechanism Exploration.
- Author
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Ou H, Pei B, Zhou Y, Yang M, Pan J, Liang S, and Cao X
- Abstract
Hard carbon (HC) is a promising anode material in alkali metal ion batteries owing to its cost-effectiveness, abundant sources, and low working voltage. However, challenges persist in achiving prolonged cycling stability and consistent capacity, and the sodium storage mechanism in HC is still debated. Herein, an unreported biomass precursor, "sisal," for deriving hard carbon is developed. A series of sisal hemp-derived hard carbon with natural 3D porous channels are prepared. Through phase characterization and electrochemical testing, the relationship between microstructure and sodium storage capacity is elucidated, further confirming the suitability of the "adsorption-insertion-filling" mechanism for sodium storage properties in hard carbon materials. Without the need for any additional modification strategies, this biomass-derived hard carbon demonstrates excellent electrochemical performance in both sodium-ion and potassium-ion batteries (SIBs and PIBs). The as-prepared HC-1300 demonstrates excellent ion storage capability, delivering a high reversible capacity of 345.2 mAh g
-1 in SIBs and 310 mAh g-1 in PIBs at 0.1 C. Moreover, it maintains a specific capacity of 237.3 mAh g-1 over 1200 cycles at 1 C when used in SIBs. The excellent cycling stability and superior rate performance are also presented in full cells, highlighting its potential for practical applications., (© 2024 Wiley‐VCH GmbH.)- Published
- 2024
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94. Discovery and Validation of Methylation Signatures in Circulating Cell-Free DNA for the Detection of Colorectal Cancer.
- Author
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Long Z, Gao Y, Han Z, Yuan H, Yu Y, Pei B, Jia Y, Ye J, Shi Y, Zhang M, Zhao Y, Wu D, and Wang F
- Subjects
- Humans, Male, Female, Middle Aged, Aged, CpG Islands genetics, Case-Control Studies, Colorectal Neoplasms genetics, Colorectal Neoplasms diagnosis, Colorectal Neoplasms blood, DNA Methylation, Cell-Free Nucleic Acids genetics, Cell-Free Nucleic Acids blood, Biomarkers, Tumor genetics, Biomarkers, Tumor blood
- Abstract
This study was conducted with the primary objective of assessing the performance of cfDNA methylation in the detection of colorectal cancer (CRC). Five tumor tissue, 20 peripheral blood leucocyte, and 169 cfDNA samples were collected for whole-genome bisulfite sequencing (WGBS) analysis. Bioinformatic analysis was conducted to identify differentially methylated regions (DMRs) and their functional characteristics. Quantitative methylation-specific PCR (qMSP) was used to validate the methylation levels of DMRs in the tissues and leucocytes. cfDNA samples from CRC patients and healthy controls were used to evaluate the performance of the DMR analysis. WGBS analysis revealed a decrease in DNA methylation levels in the CpG context in CRC tumor tissues compared with adjacent normal tissues. A total of 132 DMRs in cfDNA were identified as potential markers for diagnosing CRC. In a cohort of 95 CRC patients and 74 healthy controls, a combination of the three DMRs ( DAB1 , PPP2R5C , and FAM19A5 ) yielded an AUC of 0.763, achieving 64.21% sensitivity and 78.38% specificity in discriminating CRC patients from healthy controls. This study provides insights into DNA methylation patterns in CRC and identifies a set of DMRs in cfDNA with potential diagnostic value for CRC. These DMRs hold promise as biomarkers for CRC detection, offering promise for non-invasive CRC diagnosis. Further research is warranted to validate these findings in larger cohorts.
- Published
- 2024
- Full Text
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95. Cabozantinib as the first step toward postimmunotherapy treatment in hepatocellular carcinoma.
- Author
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Pei B, Yang H, Peng S, and Zhou F
- Subjects
- Humans, Antineoplastic Agents therapeutic use, Carcinoma, Hepatocellular drug therapy, Carcinoma, Hepatocellular therapy, Liver Neoplasms drug therapy, Liver Neoplasms therapy, Pyridines therapeutic use, Anilides therapeutic use
- Published
- 2024
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- View/download PDF
96. Effects of seaweed fertilizer application on crops' yield and quality in field conditions in China-A meta-analysis.
- Author
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Pei B, Zhang Y, Liu T, Cao J, Ji H, Hu Z, Wu X, Wang F, Lu Y, Chen N, Zhou J, Chen B, and Zhou S
- Subjects
- China, Crop Production methods, Agriculture methods, Soil chemistry, Fertilizers analysis, Seaweed growth & development, Crops, Agricultural growth & development
- Abstract
Seaweed fertilizer, formulated primarily with seaweed extract as its main ingredient, has been extensively studied and found to significantly improve nutrient use efficiency, increase crop yield and quality, and enhance soil properties under field conditions. This growing body of evidence shows that seaweed fertilizer is a suitable option for sustainable agriculture in China. However, a comprehensive and quantitative analysis of the overall effects of seaweed fertilizer application in China is lacking. To address this gap, we conducted a meta-analysis of relevant studies on the effects of seaweed fertilizers under field conditions in China with MetaWin and SPSS software. Our analysis examined the effects of seaweed fertilizers on crop yield, quality, and growth under different preparation methods, application techniques, and regions. Our results showed that the application of seaweed fertilizer led to a significant average increase in crop yield of 15.17% compared with the control treatments. Root & tuber crops exhibited the most pronounced response, with a yield boost of 21.19%. Moreover, seaweed fertilizer application significantly improved crop quality, with elevations in the sugar-acid ratio (38.32%) vitamin C (18.07%), starch (19.65%), and protein (11.45%). In addition, plant growth parameters such as height, stem thickness, root weight, and leaf area showed significant enhancement with seaweed fertilizer use. The yield-increasing effect of seaweed fertilizers varied depending on their preparation and use method, climate, and soil of application location. Our study provides fundamental reference data for the efficient and scientific application of seaweed fertilizers in agricultural practices., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Pei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
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97. Innovative BIM technology application in the construction management of highway.
- Author
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Zhou D, Pei B, Li X, Jiang D, and Wen L
- Abstract
Within the global architecture, engineering, and construction industry, the use of Building Information Modeling (BIM) technology has significantly expanded. However, given the unique characteristics of road infrastructure, the application of BIM technology is still being explored. This article focuses on the Yuanchen Expressway, exploring innovative applications of BIM technology in comprehensive construction management. The project employs advanced technologies, including BIM, Geographic Information Systems (GIS), and the Internet of Things (IoT), to precisely identify critical nodes and breakthroughs. Supported by a detailed BIM model and a multi-level, diversified digital management platform, the project effectively addresses construction challenges in multiple tunnels, bridges, and complex interchanges, achieving intelligent construction innovation throughout the Yuanchen Expressway with BIM technology. By guiding construction through BIM models, utilizing a BIM+GIS-based management cloud platform system, and employing VR safety briefings, the project effectively reduces the difficulty of communication and coordination in project management, shortens the project measurement cycle, improves on-site work efficiency, and ensures comprehensive control and safety management. This article provides an exemplary case for the application of full-line construction management using BIM technology in the highway sector both in China and globally, offering new perspectives and strategies for highway construction management., (© 2024. The Author(s).)
- Published
- 2024
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98. The Global Burden of Gynecological Diseases from 1990 to 2019.
- Author
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Cao Y, Guo Y, Long Z, Wu Y, Pei B, Ye J, Zhang M, Yuan H, Jia Y, Liu X, Wang F, and Zhao Y
- Abstract
Introduction: Gynecological diseases ranked second among new cases of noncommunicable diseases in women of reproductive age in 1990 and 2019 globally. The aim of this study was to estimate the disease burden of gynecological diseases and describe their trends in women of all ages from 1990 to 2019., Methods: Using data from the Global Burden of Diseases, Injuries and Risk Factors Study (GBD 2019), authors examined the incidence, disability-adjusted life years, and deaths from gynecological diseases by age in 204 countries and territories worldwide from 1990 to 2019. Analyses were conducted in 2022., Results: Globally, the age-standardized incidence rate and age-standardized disability-adjusted life year rate (ASDR) of gynecological diseases decreased by -0.176% and -0.245%, respectively from 1990 to 2019. Low socioeconomic development index countries had the highest age-standardized incidence rate and ASDR in 2019. The age-specific incidence rate of gynecological diseases in women aged 15-29 years increased from 1990 to 2019, and the 20-24-year age group increased the greatest by 0.21%. Polycystic ovary syndrome and other types of benign disorders contributed to the major increase., Conclusions: Although the disease burden of gynecological diseases decreased slightly between 1990 and 2019 globally, it remained highest in low socioeconomic development index countries. The disease burden in 20-24-year age group exhibited the fastest growth, with polycystic ovary syndrome and other types of benign disorders playing a significant role. Urgent and effective measures should be taken to target different age groups, types of gynecological disease, and regions with high disease burdens., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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99. Renewed call for action: Highlight negative results to improve science.
- Author
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Pei B, Yang H, and Peng S
- Abstract
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
- Published
- 2024
- Full Text
- View/download PDF
100. The association between SII and aging: evidence from NHANES 1999-2018.
- Author
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Wang N, Ren L, Li Z, Hu Y, Zhou J, Sun Q, Pei B, Li X, Peng W, Yu J, Zhao R, Huang Z, Chen Z, and Huang G
- Subjects
- Humans, Female, Middle Aged, Male, Cross-Sectional Studies, Adult, United States, Nutrition Surveys, Aging physiology, Inflammation
- Abstract
Background: The study aimed to examine the association between the systemic immune-inflammation index (SII), a contemporary metric of systemic inflammatory response, and biological aging, which are closely interconnected processes., Methods: This cross-sectional study utilized 10 cycles of data from the NHANES database spanning from 1990 to 2018. The study examined the relationship between the SII index, calculated as P * N/L, where P represents preoperative peripheral platelet count, N represents neutrophil count, and L represents lymphocyte count, and biological aging. Biological aging was assessed through various methods, such as phenotypic age, phenotypic age acceleration (PhenoAgeAccel), biological age, and biological age acceleration (BioAgeAccel). Correlations were analyzed using weighted linear regression and subgroup analysis., Results: Among the 7,491 participants analyzed, the average age was 45.26 ± 0.34 years, with 52.16% being female. The average phenotypic and biological ages were 40.06 ± 0.36 and 45.89 ± 0.32 years, respectively. Following adjustment for potential confounders, elevated SII scores were linked to increased phenotypic age, biological age, Phenotypic age acceleration, and Biological age acceleration. Positive correlations were observed between health behavior and health factor scores and biological aging, with stronger associations seen for health factors. In health factor-specific analyses, the β coefficient was notably higher for high BMI. The robust positive associations between SII scores and both phenotypic age and biological age in the stratified analyses were consistently observed across all strata., Conclusion: The evidence from the NHANES data indicate that SII may serve as a valuable marker for assessing different facets of aging and health outcomes, such as mortality and the aging process. Additional research is warranted to comprehensively elucidate the implications of SII in the aging process and its utility as a clinical instrument for evaluating and addressing age-related ailments., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wang, Ren, Li, Hu, Zhou, Sun, Pei, Li, Peng, Yu, Zhao, Huang, Chen and Huang.)
- Published
- 2024
- Full Text
- View/download PDF
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