243 results on '"Paweł, Bogdański"'
Search Results
52. Nutritional factors on the occurrence and severity of asthma
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Paweł Bogdański, Katarzyna Pastusiak, and Michalina Mróz
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,General Earth and Planetary Sciences ,Respiratory allergy ,Dietary nutrients ,medicine.disease ,business ,General Environmental Science ,Asthma - Published
- 2020
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53. Blood pressure in relation to the World Health Organization AIDS clinical staging among adults living in rural Kenya
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Paweł Bogdański, Greta Sibrecht, Piotr Prymas, Mikołaj Kamiński, Piotr Filberek, Zofia Osinska, Wojciech Sierocki, and Anna Konobrodzka
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medicine.medical_specialty ,Epidemiology ,business.industry ,Human immunodeficiency virus (HIV) ,blood pressure ,hiv ,medicine.disease_cause ,medicine.disease ,stage ,World health ,kenya ,Infectious Diseases ,Blood pressure ,Acquired immunodeficiency syndrome (AIDS) ,Family medicine ,medicine ,Medicine ,Stage (cooking) ,business ,Relation (history of concept) ,aids - Published
- 2020
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54. The Association between Serum Resistin Level, Resistin (-420C/G) Single Nucleotide Variant, and Markers of Endothelial Dysfunction, including Salt Taste Preference in Hypertensive Patients
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Katarzyna Musialik, Ewa Miller-Kasprzak, Marta Walczak, Leszek Markuszewski, and Paweł Bogdański
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Nutrition and Dietetics ,Genotype ,Nucleotides ,Taste ,Hypertension ,resistin polymorphism ,hypertension ,obesity ,salt intake ,uric acid ,arterial stiffness ,endothelial dysfunction ,Humans ,Genetic Predisposition to Disease ,Resistin ,Polymorphism, Single Nucleotide ,Biomarkers ,Food Science - Abstract
Background: Resistin action links to conditions such as diabetes, obesity, but its role in hypertension is less well understood. This study aimed to estimate the relationship between resistin (−420G/C) single nucleotide variant (SNV) and markers associated with endothelial dysfunction in hypertension. Methods: The study enrolled 162 hypertensive patients (HT) and 165 non-hypertensive (NHT) patients. Resistin serum concentration was estimated with immuoenzymatic assay. Anthropometric measurements, blood pressure and arterial stiffness index (SI), uric acid (UA) serum concentration, and salty taste preference of normal (NS) or high (HS) were assessed in the study. Genotyping was achieved by polymerase chain reaction-restriction fragment length polymorphism. Results: Resistin concentration and SI do not differ significantly between HT and NHT individuals; UA significantly increased in HT subjects. Resistin, UA, and SI did not differ among particular resistin genotypes in HT, NHT, NS, or HS groups. GG and CG genotypes were more frequent (OR 1.57 (95% CI; 1.01–2.43); p = 0.04) in hypertensive individuals than the NHT group, but less frequent (OR 0.58 (95% CI; 0.37–0.91); p = 0.01) in HS patients compared to NS individuals. Concerning HT patients with different salt preferences, GG + CG genotypes were less frequent (OR 0.50 (95% CI; 0.26–0.97); p = 0.04) in the HS group than in NS individuals. HT carriers of GG and CG genotype have significantly increased UA concentrations compared to the respective NHT subjects. HS individuals carrying GG and CG genotypes have higher SI values than the NS group. Allele G of SNV (−420G/C) adjusted for age, BMI, serum resistin, UA concentration, salt taste preference, SI, and HR values increased the risk of developing hypertensive phenotype 1.8 fold. Conclusions: Resistin SNV (−420G/C) is related to several markers associated with endothelial dysfunction, including salt taste preference in hypertensive patients.
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- 2022
55. Availability of Cardiodiabetological Drugs in Poland during the First Year of COVID-19 Pandemic: Retrospective Study
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Bartosz M. Nowak, Mikołaj Kamiński, Bartłomiej Owczarek, Monika Szulińska, and Paweł Bogdański
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Applied Mathematics ,COVID-19 ,drug stocks ,cardiovascular ,diabetes ,combination drugs ,polypill - Abstract
There were worries that the COVID-19 pandemic could result in a shortage of supplies of some drugs. We aimed to analyze if the COVID-19 pandemic resulted in the availability drop of different cardiodiabetological medicaments. Special attention was put to combined therapies and to investigate the general availability of these drugs. Data were obtained from the Polish startup company GdziePoLek regarding the availability of 121 cardiodiabetolocigal drugs divided into 23 separate categories in Polish pharmacies. The period of the analysis was limited from 1 January 2019 to 31 December 2020. The threshold of a 20% decrease of median availability was set to found drugs with the most severe drop in availability during the COVID-19 pandemic. We also identified medicaments with a median availability of less than 50%. We identified two drugs with the most severe drop in availability level during COVID-19 pandemics: acenocoumarol (decrease by 52.0%) and nitrendipine (decrease by 98.3%). In 2019 and 2020, 27 of 121 drugs had a median availability lower than 50%. The limited availability concerned the most novel agents and polypills, mostly non-insulin antidiabetic drugs. The decrease in drug availability in Poland was not as severe as expected. Accessibility to some novel non-refunded medicaments is limited.
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- 2022
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56. The Retrospective Analysis of Google Queries Related to Cardiovascular Diseases Symptoms in the Years 2004-2019
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Paweł Bogdański, Mikołaj Kamiński, and Michał Borger
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Pediatrics ,medicine.medical_specialty ,Orthopnea ,business.industry ,Edema ,medicine ,Palpitations ,Retrospective analysis ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Chest pain ,business - Abstract
The Internet enables immediate access to health-related information. We aimed to rank the complaints related to cardiovascular diseases among Google users globally and locally as well as investigate secular and seasonal trends in the years 2004 to 2019. We used Google Trends (GT) to identify and analyze course over time and regional interest of seven topics: “Chest pain,” “Cyanosis,” “Edema,” “Orthopnea,” “Palpitation,” “Shortness of breath,” and “Syncope.” We analyzed secular trends using the seasonal Mann–Kendall test and seasonal variation using time series decomposition. We calculated the interest of all topics in proportion to the relative search volume (RSV) of “Chest Pain.” Globally the most popular topics were: “Edema” (proportion to RSV of “Chest pain,” 1.39), “Chest pain” (1.00), and Syncope (0.71). “Chest pain” was predominately searched in n = 25 countries, while “Edema” in n = 24, “Syncope” in n = 9, and “Shortness of breath” in n = 3. The RSV of all topics increases over time and the most dynamically for “Chest pain” (4.30 RSV/year), “Shortness of breath” (3.87 RSV/year), and “Palpitations” (3.69 RSV/year). Interest in “Chest pain,” “Cyanosis,” “Orthopnea,” “Palpitations,” and “Syncope” peaks in fall and winter, while interest in “Edema” in midsummer and “Shortness of breath” in April. Google users were particularly interested in “Edema,” “Chest pain,” and “Syncope.” The interest in cardiovascular diseases-related symptoms increases over time and presents explicable seasonal variations. The Internet plays the acquisition of health-related information; thus, professionals should create and recommend evidence-based information sources for their patients.
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- 2022
57. The Effect of Artificial Sweeteners Use on Sweet Taste Perception and Weight Loss Efficacy: A Review
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Klara Wilk, Wiktoria Korytek, Marta Pelczyńska, Małgorzata Moszak, and Paweł Bogdański
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Non-Nutritive Sweeteners ,Nutrition and Dietetics ,Sweetening Agents ,Taste ,digestive, oral, and skin physiology ,Weight Loss ,food and beverages ,Humans ,Taste Perception ,Food Science - Abstract
Excessive consumption of sugar-rich foods is currently one of the most important factors that has led to the development of the global pandemic of obesity. On the other hand, there is evidence that obesity contributes to reduced sensitivity to sweet taste and hormonal changes affecting appetite, leading to an increased craving for sweets. A high intake of sugars increases the caloric value of the diet and, consequently, leads to weight gain. Moreover, attention is drawn to the concept of the addictive properties of sugar and sugary foods. A potential method to reduce the energy value of diet while maintaining the sweet taste is using non-nutritive sweeteners (NNS). NNS are commonly used as table sugar substitutes. This wide group of chemical compounds features high sweetness almost without calories due to its high sweetening strength. NNS include aspartame, acesulfame-K, sucralose, saccharin, cyclamate, neohesperidin dihydrochalcone (neohesperidin DC), neotame, taumatin, and advantame. The available evidence suggests that replacing sugar with NNS may support weight control. However, the effect of NNS on the regulation of appetite and sweet taste perception is not clear. Therefore, the review aimed to summarize the current knowledge about the use of NNS as a potential strategy for weight loss and their impact on sweet taste perception. Most studies have demonstrated that consumption of NNS-sweetened foods does not increase sweetness preference orenergy intake. Nonetheless, further research is required to determine the long-term effects of NNS on weight management.
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- 2022
58. Eating Behaviors, Depressive Symptoms and Lifestyle in University Students in Poland
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Julia Suwalska, Kalina Kolasińska, Dorota Łojko, and Paweł Bogdański
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Adult ,Nutrition and Dietetics ,Adolescent ,Universities ,Depression ,education ,Feeding Behavior ,Diet, Mediterranean ,Young Adult ,young adults ,emotional eating ,cognitive restraint ,uncontrolled eating ,depression ,impulsivity ,Humans ,Poland ,Students ,Life Style ,Food Science - Abstract
Young adulthood is the period from the late teens through the twenties and is associated with life transitions that could contribute to the development of obesity. Targeting this group will be critical to reversing the obesity epidemic. The aim of the study was to investigate the eating behaviors and lifestyle of healthcare students in Poland. We enrolled 227 students in the study. Convenience sampling was employed. Diet (Food Frequency Questionnaire), physical activity (International Physical Activity Questionnaire), depressive symptoms (Beck Depression Inventory), impulsivity (Barratt Impulsivity Scale), and eating behaviors (Three-Factor Eating Questionnaire) were assessed. One in three students exhibited depressive symptoms, one in four showed low levels of physical activity. More than 40% of the students did not consume vegetables at least once a day, and more than half did not consume fruit. Only approximately 50% of the students ate fish several times a month. There was an association between high scores of specific eating behaviors and body weight, adherence to the Mediterranean diet, and consumption of specific product groups (sweets, alcohol). The results of our study are expected to contribute to a better understanding of dietary habits and overweight/obesity in university students, and support the development of programs to promote healthy lifestyles in that population.
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- 2022
59. Otyłość i jej powikłania. Praktyczne zalecenia diagnostyczne i terapeutyczne
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Margit Kossobudzka, Piotr Nowicki, Marcin Grabowski, Jakub Gierczyński, Katarzyna Wilczyńska, Ewa Wender-Ożarowska, Matylda Kręgielska-Narożna, Paweł Matusik, Dominik Wretowski, Mirosław Jarosz, Tomasz Trafas, Marcin Barylski, Izabela Domitrz, Ewa Wujek-Krajewska, Aleksandra Kochańska, Mariusz Wyleżoł, Robert Rupiński, Artur Mamcarz, Piotr Pruszczyk, Maciej Janiszewski, Piotr Gałecki, Ewa Wojtyna, Michał Holecki, Michał Lew-Starowicz, Marta Walczak, Beata Matyjaszek-Matuszek, Monika Karczewska-Kupczewska, Agnieszka Beata Serwin, Anna Lis-Skowrońska, Przemysław Skowroński, Monika Lenart-Lipińska, Arkadiusz Brzozowski, Beta Zyśk, Tomasz Tomkalski, Emil Trofimiuk, Piotr Sobieraj, Irina Kowalska, Marek Kuch, Grzegorz Suwalski, Dorota Zozulińska-Ziółkiewicz, Magdalena Jodkiewicz, Zyta Beata Wojszel, Katarzyna Stopińska, Agnieszka Surwiłło-Snarska, Ewa Walewska, Hanna Wiszniewska, Małgorzata Buksińska-Lisik, Tomasz Chomiuk, Małgorzata Mrugacz, Anna Popławska-Kita, Monika Bąk-Sosnowska, Tomasz Piorunek, Iwona Boniecka, Anatol Panasiuk, Jacek Lewandowski, Paweł Bogdański, Robert Niebrzydowski, Agata Szulc, Joanna Michałowska, Medard Lech, Halina Car, Monika Szulińska, Aleksandra Kapała, Marcin Wełnicki, Beata Brajer-Luftmann, Justyna Domenik-Karłowicz, Klaudiusz Nadolny, Przemysław Kwasiborski, Michał Kowara, Joanna Cegielska, Lucyna Ostrowska, Małgorzata Wieteska, Magdalena Białkowska, Jerzy Robert Ładny, and Maria Rell-Bakalarska
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- 2021
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60. The Impact of Multispecies Probiotics on Calcium and Magnesium Status in Healthy Male Rats
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Katarzyna Skrypnik, Paweł Bogdański, Iskandar Azmy Harahap, and Joanna Suliburska
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Male ,mineral molar ratio ,chemistry.chemical_element ,Nutritional Status ,Calcium ,Biology ,multispecies probiotic ,magnesium ,Article ,law.invention ,Probiotic ,Animal science ,Molar ratio ,law ,Male rats ,Testis ,Animals ,tissues ,TX341-641 ,Femur ,Rats, Wistar ,Nutrition and Dietetics ,calcium ,Magnesium ,Nutrition. Foods and food supply ,Probiotics ,rats ,chemistry ,Femur bone ,Significant positive correlation ,Models, Animal ,Standard diet ,Food Science ,Hair - Abstract
Although probiotics have been discovered in numerous diseases in the last decade, there is little consensus on the relationship between probiotic properties and minerals balance and their distribution in the organism. This research aimed to evaluate the calcium (Ca) and magnesium (Mg) status in rats on a diet containing multispecies probiotics. Thirty male 10-week-old Wistar rats were selected and divided into three groups (n = 10 rats)—a group fed a standard diet (C), a group fed a low-dose of multispecies probiotics with 2.5 × 109 CFU per day (LD), and a group fed high-dose of multispecies probiotics 1 × 1010 CFU per day (HD) for 6 weeks. The results revealed that HD intake significantly increased the Ca concentration in hair and Mg concentration in femur bones. A significant positive correlation was found between calcium and magnesium levels in hair. The Ca/Mg molar ratio was lower in testicles in the groups with probiotics. In conclusion, multispecies probiotics altered the Ca concentration in hair and Mg level in femur bone, and also changed the molar ratio of these elements in testicles in male rats.
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- 2021
61. Increased neopterin concentration in patients with primary arterial hypertension
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Artur Cieślewicz, Katarzyna Korzeniowska, Paweł Bogdański, and Anna Jabłecka
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neopterin ,hypertension ,inflammation ,Medicine - Abstract
The data on the safety profile of anti-tumor necrosis factor (anti-TNF) therapy in real-life patients cohorts with in flammatory bowel disease (IBD) still are lacking. Neopterin is a pteridine derivative produced from guanosine triphosphate mainly by activated monocytes and macrophages in response to cytokines produced by T-lymphocytes and natural killer cells. Changes in neopterin level reflect the stage of activation of cellular immune system and can be associated with various diseases. Low-grade inflammation is also an important factor in the pathophysiology of hypertension. In presented study we assessed neopterin concentration in 63 patients with primary arterial hypertension compared to 14 control healthy volunteers. Obtained results confirmed increased neopterin level in patients group.
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- 2015
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62. Association between Fecal Microbiota, SCFA, Gut Integrity Markers and Depressive Symptoms in Patients Treated in the Past with Bariatric Surgery—The Cross-Sectional Study
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Natalia Komorniak, Alexandra Martynova-Van Kley, Armen Nalian, Michał Wroński, Krzysztof Kaseja, Bartosz Kowalewski, Karolina Kaźmierczak-Siedlecka, Igor Łoniewski, Mariusz Kaczmarczyk, Konrad Podsiadło, Paweł Bogdański, Joanna Palma, and Ewa Stachowska
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Adult ,Cross-Sectional Studies ,Nutrition and Dietetics ,Depression ,Gastric Bypass ,Humans ,Bariatric Surgery ,Fatty Acids, Volatile ,bariatric surgery ,depressive disorders ,microbiome ,Roux-en-Y gastric bypass ,sleeve gastrectomy ,depression ,Beck scale ,lipopolysaccharide ,diet ,zonulin ,Gastrointestinal Microbiome ,Obesity, Morbid ,Food Science - Abstract
(1) Background: Depressive symptoms often appear after surgical treatment. (2) Methods: We involved 41 adults who underwent bariatric surgery a minimum of 6 months before the study and had the Beck scale ≥12. We analysed patients’ mental state, gut barrier markers, faecal short chain fatty acids, and microbiota. (3) Results: Gut microbiota composition differed significantly among patients undergoing two different types of surgery (F = 1.64, p = 0.00002). Additionally, we discovered an association between short chain fatty acids and the Beck scale (F = 1.22, p = 0.058). The rearrangement of bacterial metabolites may be due to the patients’ use of increased dietary protein, with insufficient intake of products containing vegetable fiber (Diet Quality Index (DQI-I )adequacy 22.55 (±3.46) points). (4) Conclusions: Bariatric surgery affects the gut microbiota, which may play an important role in the development of depressive and gastrointestinal symptoms in patients after bariatric surgery. Low fiber consumption and increased levels of faecal isobutyric acid may lead to intestinal inflammation. There is a need for further research on this topic including a larger sample size.
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- 2022
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63. The Relation between Resistin (−420C/G) Single Nucleotide Variant, Resistin Serum Concentration, Carbohydrate, and Lipid Parameters and Fried Food Taste Preference in Patients with Hypertriglyceridemia
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Ewa Miller-Kasprzak, Katarzyna Musialik, Matylda Kręgielska-Narożna, Monika Szulińska, and Paweł Bogdański
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Nutrition and Dietetics ,resistin ,single nucleotide variants ,hypertriglyceridemia ,fried food taste preference ,metabolic parameters ,Food Science - Abstract
Background: Resistin is a proinflammatory adipokine involved in metabolic disorders. Its interplay with hypertriglyceridemia remains to be elucidated. We aimed to evaluate the relationship between resistin (−420C/G) single nucleotide variant (SNV) and metabolic parameters and preference for fried food consumption in hypertriglyceridemia. Methods: The study enrolled 179 hypertriglyceridemic (HTG) and 182 normotriglyceridemic (NTG) patients. Anthropometric measurements, serum resistin, insulin and fasting glucose concentration, a homeostatic model assessment—insulin resistance (HOMA-IR), triglycerides (TG), cholesterol concentration, and fried food taste preference (FP) or other cooking methods preference (OP) were assessed in the study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: HTG and NTG groups did not differ significantly in serum resistin concentration; HTG individuals demonstrated significantly increased serum levels of TG, glucose, total cholesterol (TCH), and HOMA-IR and decreased HDL cholesterol. Resistin, insulin, glucose, HOMA-IR, and cholesterol fractions were similar among particular resistin genotypes in HTG, NTG, FP, or OP groups. TG and TCH concentrations differ significantly among CG and CC genotypes in the FP group. Considering the FP group, GG and CG genotypes appeared more frequently in hyperlipidemic (OR 2.6 95% CI; 1.16–5.82; p = 0.01; significant after Bonferroni correction) than in NTG patients. Multivariable logistic regression models showed that the G allele and CG genotype of SNV (−420C/G), adjusted for selected confounders such as fried food preference, increased the odds of hypertriglyceridemia about twofold. Conclusions: Allele G and CG genotype of resistin SNV (−420C/G) are linked with the preference for fried food taste in hypertriglyceridemic patients.
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- 2022
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64. MALDI-TOF MS Characterisation of the Serum Proteomic Profile in Insulin-Resistant Normal-Weight Individuals
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Eliza Matuszewska, Paweł Bogdański, Dagmara Pietkiewicz, Jan Matysiak, and Katarzyna Pastusiak
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Adult ,Male ,Proteomics ,Proteome ,medicine.medical_treatment ,Serum albumin ,Ideal Body Weight ,Article ,Young Adult ,Insulin resistance ,Serotransferrin ,Diabetes mellitus ,insulin resistance ,Medicine ,Humans ,TX341-641 ,protein-peptide profiling ,MALDI ,Fibrinogen alpha chain ,Aged ,normal-weight obesity ,Nutrition and Dietetics ,Proteomic Profile ,biology ,Nutrition. Foods and food supply ,business.industry ,Insulin ,Blood Proteins ,Middle Aged ,medicine.disease ,Biochemistry ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,biology.protein ,Female ,business ,Peptides ,Biomarkers ,Food Science - Abstract
Insulin resistance (IR) is one of the most common metabolic disorders worldwide and is involved in the development of diseases, such as diabetes and cardiovascular diseases, affecting civilisations. The possibility of understanding the molecular mechanism and searching for new biomarkers useful in assessing IR can be achieved through modern research techniques such as proteomics. This study assessed the protein–peptide profile among normal-weight patients with IR to understand the mechanisms and to define new risk biomarkers. The research involved 21 IR and 43 healthy, normal-weight individuals, aged 19–65. Serum proteomic patterns were obtained using matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. The proposed methodology identified six proteins differentiating normal weight IR and insulin sensitive individuals. They were fibrinogen alpha chain, serum albumin, kininogen-1, complement C3, serotransferrin, and Ig gamma-1 chain, which could potentially be related to inflammation. However, further investigation is required to confirm their correlation with IR.
- Published
- 2021
65. The Effect of Endurance and Endurance-Strength Training on Bone Mineral Density and Content in Abdominally Obese Postmenopausal Women: A Randomized Trial
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Edyta Mądry, Radosław Mądry, Jarosław Walkowiak, Paweł Bogdański, Małgorzata Jamka, Izabela Chudzicka-Strugała, Anna Gotz-Wieckowska, Jakub Kryściak, Aleksandra Lisowska, Elnara Ismagulova, and Ainur Amanzholkyzy
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musculoskeletal diseases ,medicine.medical_specialty ,obesity ,Leadership and Management ,Health Informatics ,densitometry ,bone ,Article ,law.invention ,Health Information Management ,Randomized controlled trial ,Endurance training ,law ,Heart rate ,medicine ,Femoral neck ,Bone mineral ,exercise ,business.industry ,Health Policy ,medicine.disease ,musculoskeletal system ,Obesity ,Clinical trial ,postmenopause ,medicine.anatomical_structure ,Physical therapy ,Medicine ,business ,Densitometry - Abstract
The optimal type of exercise that simultaneously decreases body weight and preserves bone health in people with obesity is unknown. This parallel randomized trial aimed to compare the effect of endurance and endurance-strength training on bone mineral density (BMD) and content (BMC) in abdominally obese postmenopausal women. A total of 101 women were recruited and randomly assigned to endurance or endurance-strength training groups. Participants trained for 60 min per day, three times per week for 12 weeks. The endurance exercises were performed at an intensity of 50–75% of the maximum heart rate, whereas the strength exercises were at 50–60% of the one-repetition maximum. Pre- and post-intervention BMD and BMC of the total body, lumbar spine, and femoral neck and physical capacity were measured. There were no differences among the densitometric parameters in the endurance group, but a significant increase in whole-body BMD in the endurance-strength group was found. Moreover, there was a significant difference between the groups in the changes in the lumbar spine BMC. Furthermore, both training programs significantly improved physical capacity with no differences between groups. Endurance training was more effective in maintaining BMC at the lumbar spine. However, both groups did not differ in effect on BMD. Further studies with a long-term follow-up should be considered to confirm these findings. The study was registered with the German Clinical Trials Register within the number DRKS00019832, and the date of registration was 26 February 2020 (retrospective registration).
- Published
- 2021
66. Type of Physical Training and Selected Aspects of Psychological Functioning of Women with Obesity: A Randomised Trial
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Damian Skrypnik, Magdalena Gruszczyńska, Paweł Bogdański, Monika Bąk-Sosnowska, Marzena Ratajczak, Jarosław Walkowiak, Joanna Karolkiewicz, Edyta Mądry, and Sławomir Grzegorczyn
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Adult ,medicine.medical_specialty ,obesity ,Adolescent ,body image ,Physical activity ,physical activity ,030209 endocrinology & metabolism ,Article ,Body Mass Index ,Anthropometric parameters ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endurance training ,medicine ,Humans ,TX341-641 ,030212 general & internal medicine ,Trial registration ,Aged ,Nutrition and Dietetics ,psychological aspects ,Waist-Hip Ratio ,business.industry ,Nutrition. Foods and food supply ,Resistance Training ,Feeding Behavior ,Middle Aged ,Emotional eating ,Anthropometry ,medicine.disease ,Obesity ,Self Concept ,Endurance Training ,Physical therapy ,Female ,Psychological aspects ,business ,Stress, Psychological ,Food Science - Abstract
Objective: We conducted a prospective randomised trial to assess whether a specific type of regular physical training performed by women with obesity is related to obtaining specific psychological benefits. Methods: Forty-four women qualified for the study and were divided into two groups. The applied intervention consisted of regular three-month physical exercises in the form of endurance training (group A) or endurance strength training (group B). Initially, and after the completed intervention, we examined anthropometric measurements and the level of: stress (PSS-10), general self-esteem (SES), body self-report (BSQ–34, FRS), and behaviours associated with diet (TFEQ-18). Results: As a result of the intervention, both groups had significantly lower anthropometric parameters and FRS scores with regard to the current figure (gr. A:δ FRS CS −0.90 ± 0.83, p <, 0.001, gr. B:δ FRS CS −0.41 ± 0.50, p = 0.01) and BSQ–34 results (gr. A:δ BSQ–34 −14.90 ± 13.5, p = 0.001, gr. B:δ BSQ–34 − 18.64 ± 25.4, p = 0.01). Additionally, an increase in cognitive restraint (δ TFEQ–18 CR1.65 ± 2.06, p = 0.01) and a decrease in emotional eating (δ TFEQ–18 EE −0.82 ± 1.28, p = 0.01) were observed in group B. There were no between-group differences in terms of the magnitude of changes achieved due to the intervention, except for asignificant improvement in the perception of their current figure (FRS) (δ FRSCS −0.90 ± 0.83, p = 0.03) in group A. Conclusions: Regular physical activity over a three-month period by women with obesity promotes the perception of their own body as slimmer and lowers body shape concerns. The change in body shape perception was more pronounced under the influence of endurance training than endurance strength training. Trial registration: ClinicalTrials.gov ID NCT04793451.
- Published
- 2021
67. Comparison of the effects of endurance and endurance‑strength training programmes on the level of endothelial dysfunction in women with abdominal obesity: study protocol for a randomised controlled trial
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Patrycja Krzyżanowska-Jankowska, Aleksandra Lisowska, Jarosław Walkowiak, Paweł Bogdański, Małgorzata Jamka, Edyta Mądry, Radosław Mądry, and Joanna Karolkiewicz
- Subjects
medicine.medical_specialty ,business.industry ,Insulin ,medicine.medical_treatment ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Anthropometry ,medicine.disease ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Endurance training ,medicine ,Physical therapy ,Population study ,Endothelial dysfunction ,medicine.symptom ,business ,Abdominal obesity - Abstract
The primary objective of the study is to compare the effect of endurance and endurance‑strength training on endothelial function in women with abdominal obesity. The secondary objectives include the assessment of the effect of both types of training on anthropometric, densitometric and biochemical parameters. In total, at least 100 women will be recruited for the study. The study population will be randomly divided into two groups according to the type of training: endurance and endurance‑strength training. During the 3-month of intervention, both groups will be performed three times a week training of an equal exercise volume and duration of 60 minutes. Before and after the intervention selected anthropometric and densitometric parameters will be measured and body composition will be analysed. In addition, biochemical parameters related to glucose and insulin homeostasis, lipid metabolism, antioxidant status, oxidative stress, inflammatory markers and endothelial function will be assessed.
- Published
- 2019
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68. The Effect of Multispecies Probiotic Supplementation on Iron Status in Rats
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Joanna Suliburska, Marcin Schmidt, Katarzyna Skrypnik, and Paweł Bogdański
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Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Iron ,Clinical Biochemistry ,Total iron binding capacity ,Administration, Oral ,Spleen ,010501 environmental sciences ,Gut flora ,Placebo ,Probiotic ,01 natural sciences ,Biochemistry ,Article ,law.invention ,Inorganic Chemistry ,03 medical and health sciences ,Total iron-binding capacity ,law ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,0105 earth and related environmental sciences ,0303 health sciences ,Minerals ,medicine.diagnostic_test ,biology ,Dose-Response Relationship, Drug ,Chemistry ,Probiotics ,030302 biochemistry & molecular biology ,Biochemistry (medical) ,General Medicine ,Metabolism ,biology.organism_classification ,Iron metabolism ,Bioavailability ,Rats ,Zinc ,medicine.anatomical_structure ,Endocrinology ,Dietary Supplements ,Duodenum ,Copper - Abstract
A range of interactions between gut microbiota and iron (Fe) metabolism is described. Oral probiotics ameliorate host’s iron status. However, this has been proven for single-strain probiotic supplements. Dose-dependence of beneficial probiotic supplementation effect on iron turnover remains unexplored. Our study aimed to investigate the effects of oral multispecies probiotic supplementation in two doses on iron status in rats. Thirty rats were randomized into three groups receiving multispecies probiotic supplement at a daily dose of 2.5 × 109 CFU (PA group, n = 10) and 1 × 1010 CFU (PB group, n = 10) or placebo (KK group, n = 10). After 6 weeks, rats were sacrificed for analysis, blood samples, and organs (the liver, heart, kidneys, spleen, pancreas, femur, testicles, duodenum, and hair) were collected. The total fecal bacteria content was higher in the PB group vs. PA group. Unsaturated iron-binding capacity was higher in the PB group vs. KK group. Serum Fe was lower in both PA and PB vs. KK group. Iron content in the liver was higher in the PB group vs. KK group; in the pancreas, this was higher in the PB group vs. the KK and PA group, and in the duodenum, it was higher in both supplemented groups vs. the KK group. A range of alterations in zinc and copper status and correlations between analyzed parameters were found. Oral multispecies probiotic supplementation exerts dose-independent and beneficial effect on iron bioavailability and duodenal iron absorption in the rat model, induces a dose-independent iron shift from serum and intensifies dose-dependent pancreatic and liver iron uptake.
- Published
- 2019
69. Corrigendum to 'Influence of multistrain probiotic and iron supplementation on iron status in rats' [J. Trace Elem. Med. Biol. 68 (2021) 126849]
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Katarzyna Skrypnik, Paweł Bogdański, Magdalena Sobieska, Marcin Schmidt, and Joanna Suliburska
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Inorganic Chemistry ,Molecular Medicine ,Biochemistry - Published
- 2022
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70. Clinical outcomes of conjugated linoleic acid supplementation in the overweight and the obese: a study protocol
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Klaudia Łochocka, Aleksandra Glapa, Jan Krzysztof Nowak, Monika Duś-Żuchowska, Katarzyna Grabańska, Paweł Bogdański, Ewa Fidler, Edyta Mądry, and Jarosław Walkowiak
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obesity ,randomized ,digestion ,absorption ,body composition ,lipid profile ,Medicine - Abstract
This is the protocol of a study aiming to assess the impact of conjugated linoleic acid (CLA) on body mass and composition, carbohydrate and fat digestion and absorption, total energy expenditure, lipid profile, polyunsaturated fatty acids levels, markers of endothelial dysfunction and mineral status in humans. Seventy-four adult volunteers (BMI ? 25 kg/m2) will be randomized to receive 3.0 g of 80% CLA (50:50 cis-9, trans-11 and trans-10, cis-12 isomers) or 3.0 g of linoleic acid daily for 3 months. A range of parameters will be measured at baseline and after the intervention.
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- 2014
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71. Osteopontin – a multifunctional protein and its impact on an insulin resistance development
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Katarzyna Musialik, Damian Skrypnik, Paweł Bogdański, and Monika Szulińska
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osteopontin ,coronary artery disease ,insulin resistance ,Medicine - Abstract
Osteopontin (OPN) is one of the many physiological elements creating human musculoskeletal system. It is suspected that this protein is one of the most important mediators responsible for osseous tissue mass resorption, regulated by parthormon. The origin of its name comes from one of its physiological action – rebuilding of the bone mass structure (osteo – bone, pontin – bridge). Osteopontin fulfils many different actions being secreted by many different types of cells, including macrophages, lymphocytes, epithelial cells, vascular smooth muscle cells, and osteoblasts. OPN plays an important part in inflammatory process. It provokes macrophages and dendritic cells to movement into the destination where inflammatory process takes place. It also stimulates macrophages to interleukin 12 (IL12) and interferon ? (IFN ?) secretion. Increased OPN concentration in blood stream might be regarded as a novel, independent indicator of coronary artery disease. Osteopontin plays an important role in macrophage infiltration of the adipose tissue and at the same time contributes to insulin resistance. Obesity induces chronic, low-grade tissue inflammation. Positive correlation was observed between body mass index (BMI) and number of macrophages accumulated in the fat tissue. Once aroused monocytes infiltrate the adipose tissue, which leads to persisting chronic inflammation. At the same time the excreted by them cytokines may be connected with the mechanisms of obesity-induced insulin resistance.
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- 2014
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72. The effect of endurance and endurance-strength training on body composition and cardiometabolic markers in abdominally obese women: a randomised trial
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Paweł Bogdański, Małgorzata Jamka, Patrycja Krzyżanowska-Jankowska, Edyta Mądry, Anna Gotz-Wieckowska, Jarosław Walkowiak, Monika Szulińska, Gulnara Batyrova, Monika Duś-Żuchowska, Damian Skrypnik, Radosław Mądry, and Aleksandra Lisowska
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Lifestyle modification ,Blood Glucose ,medicine.medical_specialty ,Free fat ,Science ,Diastole ,Abdominal Fat ,Adipose tissue ,Blood Pressure ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Endurance training ,Internal medicine ,Weight management ,medicine ,Humans ,030212 general & internal medicine ,Obesity ,Multidisciplinary ,biology ,business.industry ,Paraoxonase ,Cardiometabolic Risk Factors ,Middle Aged ,Lipid Metabolism ,Clinical trial ,Endurance Training ,Blood pressure ,Lean body mass ,biology.protein ,Body Composition ,Medicine ,Female ,business - Abstract
Studies comparing the effect of endurance and endurance-strength training on cardiometabolic markers provided inconsistent results. Therefore, the study aimed to compare the effect of endurance and endurance-strength training on body composition and cardiometabolic parameters in abdominally obese women. In this randomised trial, 101 subjects were included and divided into endurance (n = 52) and endurance-strength (n = 49) training. During the 12-week intervention, participants performed supervised one-hour training three times a week. Body composition, blood pressure (BP), markers of glucose and lipid homeostasis, and myoglobin levels were measured before and after the intervention. In total, 85 subjects completed the trial. Both interventions decreased fat mass and visceral adipose tissue and increased free fat mass, appendicular lean mass index and lean mass index. Neither endurance training nor endurance-strength training affected glucose and lipid metabolism. However, only endurance training significantly decreased paraoxonase and myoglobin levels. Both training programmes significantly decreased BP, with a more reduction of diastolic BP noted in the endurance group. In conclusion, both training programmes had a favourable effect on body composition but did not improve glucose and lipid homeostasis. Besides, endurance training decreased paraoxonase activity and myoglobin levels and was more effective in reducing BP.The study was registered with the German Clinical Trials Register (DRKS) within the number: DRKS00019832 (retrospective registration), date of registration: 26/02/2020.
- Published
- 2021
73. Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance
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Katarzyna Skrypnik, Damian Skrypnik, Paweł Bogdański, Jan Aaseth, Anatoly V. Skalny, Alexey A. Tinkov, Margarita G. Skalnaya, and Joanna Suliburska
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Adult ,Serum ,0301 basic medicine ,medicine.medical_specialty ,obesity ,Urine ,Microbiology ,Biochemistry ,Body fat percentage ,Article ,metabolic syndrome ,03 medical and health sciences ,chemistry.chemical_compound ,Insulin resistance ,Internal medicine ,insulin resistance ,medicine ,Humans ,selenium ,Molecular Biology ,Triglycerides ,Aged ,Minerals ,030109 nutrition & dietetics ,Triglyceride ,medicine.diagnostic_test ,Middle Aged ,medicine.disease ,Obesity ,QR1-502 ,Trace Elements ,Logistic Models ,030104 developmental biology ,Endocrinology ,Blood pressure ,chemistry ,Case-Control Studies ,copper ,Body Composition ,Female ,Metabolic syndrome ,Lipid profile ,Hair - Abstract
The objective of this study was to evaluate serum, hair, and urinary trace element and mineral content in normal-weight and obese women in relation to metabolic risk factors. A total of 80 women aged 30–70 y.o. were enrolled in the obese group (n = 40) and normal-weight group (n = 40). Serum, hair, and urinary trace element and mineral levels were assessed using inductively coupled plasma spectrometry. Body fat percentage was evaluated using bioimpedance. Obese subjects were characterized by significantly higher body fat percentage, blood pressure, serum triglyceride concentration, and insulin resistance. Serum Ca, Fe, Mg, Se, V, Zn levels, hair Fe, Mg, V content, and urinary Se and V concentrations were found to be lower in obese subjects as compared to lean controls. In turn, serum Cu and urinary Fe levels in obese women were characterized by a significant increase. In multiple regression models serum Cu, Se, and Zn levels were significantly associated with BMI even after adjustment for blood biochemistry, body composition, and blood pressure. Serum trace element and mineral levels also significantly contributed to group discrimination. These findings allow to propose that obesity-associated disturbances in trace element and mineral status may at least partially contribute to metabolic risk in obese subjects.
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- 2021
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74. Perinatal Mental Health during COVID-19 Pandemic: An Integrative Review and Implications for Clinical Practice
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Aleksandra Suwalska, Katarzyna Wszołek, Paweł Bogdański, Maria Napierała, Dorota Łojko, Sara Suchowiak, and Julia Suwalska
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medicine.medical_specialty ,Telemedicine ,Psychological intervention ,integrative review ,Review ,restrictions ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Pandemic ,medicine ,perinatal mental health ,030212 general & internal medicine ,Social isolation ,Psychiatry ,Depression (differential diagnoses) ,030219 obstetrics & reproductive medicine ,business.industry ,pandemic ,COVID-19 ,General Medicine ,social support ,anxiety ,Mental health ,depression ,Anxiety ,Medicine ,telemedicine ,medicine.symptom ,business - Abstract
The COVID-19 pandemic and measures implemented to decelerate its spread have consequences for mental health of societies. The aim of our review was to analyze depressive and anxiety symptoms in perinatal women. The search used PubMed and Web of Science databases. Most studies showed an increase in the prevalence of depression and/or anxiety symptoms. Risk factors identified in our study were mainly related to the possibility of COVID-19 infection, changes in the organization of perinatal care, social isolation and financial problems. Protective factors included social support, the woman’s own activity and knowledge about COVID-19. The results of our study point to the importance of the mental health screening including suicide risk assessment in perinatal women. Much of the mental health needs of perinatal women can be met in primary or perinatal care services; however, women with mental health issues should be offered psychiatric consultations and psychological support, and sometimes urgent psychiatric hospitalization is necessary. Healthcare professionals should provide information addressing uncertainty about COVID-19, organization of midwifery and medical care as well as mental health problems and how to get help. Mental health interventions in pregnant women may involve planning physical activity and encouraging to engage in online social activities.
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- 2021
75. Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training
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Jarosław Walkowiak, Saule Iskakova, Patrycja Krzyżanowska-Jankowska, Anna Gotz-Wieckowska, Anna Miśkiewicz-Chotnicka, Joanna Karolkiewicz, Edyta Mądry, Monika Duś-Żuchowska, Paweł Bogdański, Małgorzata Jamka, Radosław Mądry, and Aleksandra Lisowska
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cardiovascular risk ,medicine.medical_specialty ,lcsh:Medicine ,030204 cardiovascular system & hematology ,medicine.disease_cause ,antioxidant status ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Endurance training ,Internal medicine ,medicine ,oxidative stress ,Pulse wave velocity ,Abdominal obesity ,business.industry ,lcsh:R ,Interleukin ,030229 sport sciences ,General Medicine ,medicine.disease ,inflammatory markers ,Endocrinology ,Blood pressure ,Arterial stiffness ,medicine.symptom ,business ,Oxidative stress - Abstract
Limited data suggested that inclusion of a strength component into endurance exercises might intensify the beneficial effect of training. However, the available data is limited. Therefore, we aimed to compare the effect of endurance and endurance-strength training on anthropometric parameters, endothelial function, arterial stiffness, antioxidant status, and inflammatory markers in abdominally obese women without serious comorbidities. A total of 101 women were recruited and randomly divided into endurance (n = 52) and endurance-strength (n = 49) groups. During the three-month intervention, both groups performed supervised sixty-minute training three times a week. All studied parameters were measured pre- and post-intervention period. In total, 85 women completed the study. Both training significantly decreased anthropometric parameters. Besides, endurance training decreased endothelial nitric oxide synthase, central aortic systolic pressure, pulse wave velocity, glutathione (GSH), total antioxidant status (TAS), interleukin (IL) 8, matrix metalloproteinase (MMP) 9, and tumor necrosis factor alpha, while endurance-strength training decreased MMP-2 concentrations, and increased IL-6, monocyte chemoattractant protein-1, and MMP-9 levels. We observed significant differences between groups for GSH, TAS, and MMP-9 levels. In summary, endurance and endurance-strength training did not differ in the impact on endothelial function and arterial stiffness. However, endurance training significantly depleted the antioxidant defense, simultaneously reducing MMP-9 levels. The study was retrospectively registered with the German Clinical Trials Register within the number DRKS00019832.
- Published
- 2021
76. Social Modeling and Eating Behavior—A Narrative Review
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Julia Suwalska and Paweł Bogdański
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0301 basic medicine ,Male ,Health Knowledge, Attitudes, Practice ,food intake ,lcsh:TX341-641 ,Review ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Social Norms ,Humans ,030212 general & internal medicine ,Social Behavior ,Social influence ,Consumption (economics) ,Social modeling ,Sex Characteristics ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Snacking ,Field (Bourdieu) ,Body Weight ,digestive, oral, and skin physiology ,Feeding Behavior ,Variety (cybernetics) ,social matching ,Eating behavior ,Narrative review ,Female ,Psychology ,lcsh:Nutrition. Foods and food supply ,social influence ,mimicry ,Food Science - Abstract
Social modeling of eating is the adjustment of the amount of food eaten to the intake of the accompanying person. In this paper we provide a narrative review of literature on social modeling of eating with a particular focus on recent studies. Firstly, we describe the structure of a typical modeling experiment. Secondly, we present a variety of research in this field: experiments with various types of confederates, experiments aimed at the evaluation of the influence of gender, partner’s body weight, type of food, hunger, personal characteristics, etc. Thirdly, we present practical implications of this knowledge. The common conclusion is that social modeling of eating occurs in different situations and consumption is adapted to the standards established by the eating partner, but is not their direct reflection. Social influence of eating is not restricted to "artificial" laboratory situations; social modeling and social norms manipulations may be used to change people’s dietary practices, especially in children and young adults. Within the home environment parental modeling has been shown to promote children’s snacking and fruit and vegetable consumption. Social modeling may be used in nutrition interventions aimed at the improvement of children’s diet and in obesity prevention programs.
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- 2021
77. Comparison of Polish and international guidelines on diet supplements in pregnancy — review
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Damian Skrypnik, Ewa Wender-Ozegowska, Małgorzata Moszak, and Paweł Bogdański
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medicine.medical_specialty ,Anemia ,Pregnancy review ,03 medical and health sciences ,Folic Acid ,0302 clinical medicine ,Pregnancy ,Vitamin D and neurology ,Humans ,Medicine ,chemistry.chemical_classification ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Vitamins ,medicine.disease ,Diet ,chemistry ,Docosahexaenoic acid ,Premature birth ,Dietary Supplements ,Gestation ,Female ,Poland ,business ,Essential nutrient - Abstract
Proper nutrition is an important element that determines the course of pregnancy. Unfortunately, the everyday diet is not always able to cover the increased in pregnancy essential vitamins and minerals requirements. Therefore, pregnant women often use dietary supplements. This study aimed to compare Polish and international recommendations regarding dietary supplementation during pregnancy. The Polish Society of Gynaecologists and Obstetricians (PSGO) recommends in every pregnant woman the dietary supplementation of folates, vitamin D and iodine. Additionally, the benefits of iron supplementation in pregnant women with anemia or at high risk of developing anemia are also highlighted. In the light of Polish guidelines, the magnesium supplementation is recommended in the condition of its reduced level in blood. In the case of limited consumption of DHA (docosahexaenoic acid), Polish guidelines recommend in pregnant women's diet, at least 600 mg of DHA every day. Still, in case of the high risk of premature birth - at least 1000 mg DHA a day during the entire pregnancy period should be taken.
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- 2021
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78. Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients
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Marta Pelczyńska, Teresa Grzelak, Paweł Bogdański, Aniceta Ada Mikulska, and Krystyna Czyżewska
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Adult ,0301 basic medicine ,total antioxidant status ,animal structures ,hypertension ,Circadian clock ,lcsh:QR1-502 ,CLOCK Proteins ,Physiology ,Blood Pressure ,cryptochrome 1 ,030204 cardiovascular system & hematology ,Biochemistry ,Article ,lcsh:Microbiology ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,circadian clock ,Humans ,Medicine ,Circadian rhythm ,Exercise ,Life Style ,Molecular Biology ,circadian locomotor output cycles kaput ,Aged ,Metabolic Syndrome ,Sleep quality ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Anthropometry ,Cryptochromes ,Antioxidant capacity ,030104 developmental biology ,Blood pressure ,Case-Control Studies ,Female ,Sleep ,business ,Lipid profile ,diet ,Biomarkers ,biological clocks - Abstract
Background: Circadian rhythms misalignment is associated with hypertension. The aim of the study was to evaluate the concentration of selected clock proteins—cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, and quality of sleep) in hypertensive patients. Methods: In 31 females with hypertension (HT) and 55 non-hypertensive women (NHT) the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile, and glycemia were analyzed. Blood pressure and anthropometric measurements, nutritional, exercise, and sleep analyses were performed. Results: In the HT group, the CRY1 level was 37.38% lower than in the NHT group. No differences were noted in CLOCK concentration between groups. BMI, FBG, and TG were higher in the HT group compared to the NHT group, while TC, LDL, and HDL levels were similar. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity, or sleep quality, although CRY1 was associated with some anthropometric indicators. In the HT group, increased CLOCK and CRY1 values were associated with a high TAS level. Conclusions: The serum level of CRY1 could be considered in a detailed diagnostic of hypertension risk in populations with abnormal anthropometric indices.
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- 2021
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79. Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome
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Damian Skrypnik, Maciej Owecki, Paweł Bogdański, and Małgorzata Mirr
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Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Overweight ,Gastroenterology ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Internal medicine ,medicine ,Humans ,Obesity ,Triglycerides ,Metabolic Syndrome ,Receiver operating characteristic ,Anthropometry ,business.industry ,Cholesterol, HDL ,Area under the curve ,Reproducibility of Results ,Blood Pressure Determination ,Middle Aged ,medicine.disease ,ROC Curve ,Area Under Curve ,Female ,Original Article ,Metabolic syndrome ,medicine.symptom ,business ,Body mass index ,Biomarkers - Abstract
Purpose Obesity and insulin resistance are considered cardinal to the pathophysiology of metabolic syndrome. Several simple indexes of insulin resistance calculated from biochemical or anthropometric variables have been proposed. The study aimed to assess the diagnostic accuracy of indirect insulin resistance indicators in detecting metabolic syndrome in non-diabetic patients, including TG/HDLc, METS-IR, TyG, TyG-BMI, TyG-WC, TyG-WHtR, and new indicators TyG-NC (TyG-neck circumference) and TyG-NHtR (Tyg-neck circumference to height ratio). Methods The diagnostic accuracy of eight insulin resistance indexes was assessed using the receiver operating characteristic curves (ROC curves) in 665 adult non-diabetic patients. Then, the analysis was performed after the division into groups with proper body mass index, overweight and obese. Results All indexes achieved significant diagnostic accuracy, with the highest AUC (area under the curve) for TyG (0.888) and Tg/HDLc (0.874). The highest diagnostic performance in group with the proper body mass index was shown for TyG (0.909) and TyG-BMI (0.879). The highest accuracy in the group of overweight individuals was presented by TyG (0.884) and TG/HDLc (0.855). TG/HDLc and TyG showed the highest AUC (0.880 and 0.877, respectively) in the group with obesity. Both TyG-NC and TyG-NHtR reached significant areas under the curve, which makes them useful diagnostic tests in metabolic syndrome. Conclusions Indirect indices of insulin resistance, including proposed TyG-NC and TyG-NHtR, show an essential diagnostic value in diagnosing metabolic syndrome. TyG and TG/HDLc seem to be the most useful in the Caucasian population.
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- 2021
80. Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date
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Małgorzata Moszak, Marta Walczak-Gałęzewska, Paweł Bogdański, and Monika Szulińska
- Subjects
Health, Toxicology and Mutagenesis ,lcsh:Medicine ,Disease ,Type 2 diabetes ,Review ,Gut flora ,Bioinformatics ,digestive system ,Pathogenesis ,03 medical and health sciences ,Global population ,bioactive substances ,0302 clinical medicine ,Non-alcoholic Fatty Liver Disease ,NAFLD ,Medicine ,Humans ,030304 developmental biology ,0303 health sciences ,biology ,gut microbiota ,business.industry ,Probiotics ,lcsh:R ,Fatty liver ,Public Health, Environmental and Occupational Health ,NASH ,biology.organism_classification ,medicine.disease ,digestive system diseases ,Gastrointestinal Microbiome ,Prebiotics ,Diabetes Mellitus, Type 2 ,Dysbiosis ,030211 gastroenterology & hepatology ,business ,diet ,Kidney disease - Abstract
Non-alcoholic fatty liver disease (NAFLD) is a significant clinical and epidemiological problem that affects around 25% of the adult global population. A large body of clinical evidence highlights that NAFLD is associated with increased liver-related morbidity and mortality and an increased risk of cardiovascular disease, extrahepatic cancers, type 2 diabetes, and chronic kidney disease. Recently, a series of studies revealed the pivotal role of gut microbiota (GM) dysbiosis in NAFLD’s pathogenesis. The GM plays an essential role in different metabolic pathways, including the fermentation of diet polysaccharides, energy harvest, choline regulation, and bile acid metabolism. One of the most critical factors in GM stabilization is the diet; therefore, nutritional therapyappearsto be a promising tool in NAFLD therapy. This paper aims to review the current knowledge regardingthe nutritional approach and its implications with GM and NAFLD treatment. We discuss the positive impact of probiotics, prebiotics, and symbiotics in a reverse dysbiosis state in NAFLD and show the potential beneficial effects of bioactive substances from the diet. The full description of the mechanism of action and comprehensive examination of the impact of nutritional interventions on GM modulation may, in the future, be a simple but essential tool supporting NAFLD therapy.
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- 2021
81. The effect of
- Author
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Damian, Skrypnik, Katarzyna, Skrypnik, Marta, Pelczyńska, Magdalena, Sobieska, Alexey A, Tinkov, Joanna, Suliburska, and Paweł, Bogdański
- Subjects
Adult ,Leptin ,Vascular Endothelial Growth Factor A ,Double-Blind Method ,Administration, Oral ,Humans ,Female ,Obesity ,Plant Preparations ,Middle Aged ,Plantago - Abstract
Obesity is associated with increased serum leptin level, endothelial dysfunction and angiogenesis. In vitro studies have shown that vascular endothelial growth factor (VEGF) synthesis is increased by leptin. Animal studies revealed the effectiveness of Plantago supplementation treatment of obesity. The study aim was to evaluate the effect of Plantago major supplementation on serum leptin and VEGF blood concentration, endothelial dysfunction and angiogenesis in obese women. Seventy-two obese women received oral Plantago major supplement (Plantago group, n = 35) or placebo (placebo group, n = 37) for 12 weeks. At baseline and after completion, anthropometric and body composition measurements were performed, and blood samples were collected. Serum concentrations of leptin, VEGF-A, adiponectin, tumour necrosis factor α and soluble intercellular adhesion molecule have been determined. At completion, the leptin level was higher in the Plantago group (39 781.55 ± 20 360.73 pg ml-1) compared to both the baseline (36 138.71 ± 25 401.51 pg ml-1) and placebo group (30 502.81 ± 19 003.18 pg ml-1). Also, leptin concentration in the Plantago group at completion correlated positively with an increase in VEGF-A level (R = 0.45), and baseline VEGF-A level correlated negatively with the increase in leptin concentration (R = -0.47). Plantago major supplementation increases leptin serum level, enhances leptin influence on VEGF-A serum level increase and by this mechanism may intensify endothelial dysfunction and angiogenesis in obese women.
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- 2021
82. Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
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Ingrid Wise, Bradley Godfrey, Raymond T. O'Keefe, Mikael Ekholm, Wojciech Wystrychowski, Pasquale Maffia, Matthias Kretzler, Sushant Saluja, James Eales, Artur Akbarov, Christopher Finan, Maciej Tomaszewski, Monika Szulińska, Gosia Trynka, Matthew Denniff, Sanjeev Pramanik, Ewa Zukowska-Szczechowska, Bernard Keavney, Andrew P. Morris, Yusif Shakanti, Sandesh Chopade, John Bowes, Eddie Cano-Gamez, Huw B. Thomas, Matthew G. Sampson, Xiaoguang Xu, Evangelos Evangelou, Paweł Bogdański, Priscilla R. Prestes, Stephen Eyre, Xiao Jiang, David Talavera, Fadi J. Charchar, Hui Guo, Andrzej Antczak, Joanna Zywiec, Nilesh J. Samani, Alicja Nazgiewicz, Michelle T. McNulty, Adrian S. Woolf, Robert Król, Tomasz J. Guzik, Jason Brown, Carlo Berzuini, Mahan Salehi, Maciej Glyda, Aroon D. Hingorani, Felix Eichinger, Mark J. Caulfield, Eales, J. M., Jiang, X., Xu, X., Saluja, S., Akbarov, A., Cano-Gamez, E., Mcnulty, M. T., Finan, C., Guo, H., Wystrychowski, W., Szulinska, M., Thomas, H. B., Pramanik, S., Chopade, S., Prestes, P. R., Wise, I., Evangelou, E., Salehi, M., Shakanti, Y., Ekholm, M., Denniff, M., Nazgiewicz, A., Eichinger, F., Godfrey, B., Antczak, A., Glyda, M., Krol, R., Eyre, S., Brown, J., Berzuini, C., Bowes, J., Caulfield, M., Zukowska-Szczechowska, E., Zywiec, J., Bogdanski, P., Kretzler, M., Woolf, A. S., Talavera, D., Keavney, B., Maffia, P., Guzik, T. J., O'Keefe, R. T., Trynka, G., Samani, N. J., Hingorani, A., Sampson, M. G., Morris, A. P., Charchar, F. J., and Tomaszewski, M.
- Subjects
Quantitative Trait Loci ,Genome-wide association study ,Blood Pressure ,Quantitative trait locus ,Biology ,Kidney ,Polymorphism, Single Nucleotide ,Transcriptome ,03 medical and health sciences ,0302 clinical medicine ,Mendelian randomization ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Mendelian Randomization Analysi ,030304 developmental biology ,0303 health sciences ,Genetic Variation ,Mendelian Randomization Analysis ,Epigenome ,Genomics ,DNA Methylation ,Alternative Splicing ,medicine.anatomical_structure ,DNA methylation ,Hypertension ,030217 neurology & neurosurgery ,Human ,Genome-Wide Association Study - Abstract
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and antihypertensive treatment. However, genetically mediated renal mechanisms underlying susceptibility to hypertension remain poorly understood. We integrated genotype, gene expression, alternative splicing and DNA methylation profiles of up to 430 human kidneys to characterize the effects of BP index variants from genome-wide association studies (GWASs) on renal transcriptome and epigenome. We uncovered kidney targets for 479 (58.3%) BP-GWAS variants and paired 49 BP-GWAS kidney genes with 210 licensed drugs. Our colocalization and Mendelian randomization analyses identified 179 unique kidney genes with evidence of putatively causal effects on BP. Through Mendelian randomization, we also uncovered effects of BP on renal outcomes commonly affecting patients with hypertension. Collectively, our studies identified genetic variants, kidney genes, molecular mechanisms and biological pathways of key relevance to the genetic regulation of BP and inherited susceptibility to hypertension.
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- 2021
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83. Assessment of Selected Clock Proteins (CLOCK, CRY1) and their Relationship with Biochemical, Anthropometric and Lifestyle Parameters in Hypertensive Patients
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Krystyna Czyżewska, Paweł Bogdański, Marta Pelczyńska, Aniceta Ada Mikulska, and Teresa Grzelak
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animal structures ,business.industry ,allergology ,Circadian clock ,Medicine ,CLOCK Proteins ,Anthropometry ,business ,Bioinformatics ,Cryptochrome-1 - Abstract
Circadian rhythms misalignment is associated with hypertension. The aim of the study was to evaluate the concentration of selected clock proteins- cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) and to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, quality of sleep) in hypertensive patients. In 25 female with hypertension (HT) and 49 non-hypertensive women (NHT), the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile and glycemia were conducted. Blood pressure and anthropometric measurements, nutritional, exercise and sleep analyses were performed. In HT the CRY1 level was 40.2% lower than in the NHT. No differences were noted in CLOCK concentration between groups. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity and sleep quality, although CRY1 was associated with some anthropometric parameters. There was a negative correlation between the CLOCK concentration and the amount of saturated fatty acids consumed (24h) in HT. That indicates the possible influence of the diet on the CLOCK level. In a detailed prognosis of the risk of hypertension, it is worth considering the measurement of the level of CRY1 in populations with abnormal anthropometric indices.
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- 2020
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84. Effect of the introduction of pictorial cigarette pack warnings in Poland: a retrospective analysis of the market sales data of a large convenience store franchise
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Matylda Kręgielska-Narożna, Mikołaj Kamiński, Jan Krzysztof Nowak, and Paweł Bogdański
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business.industry ,Smoking ,MEDLINE ,Commerce ,Advertising ,Tobacco Products ,Internal Medicine ,Retrospective analysis ,Medicine ,Humans ,Franchise ,Poland ,business ,Cigarette pack ,Retrospective Studies - Published
- 2020
85. Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney
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Maciej Tomaszewski, Louise M Burrell, Stephen Harrap, Damian Skrypnik, Eddie Cano-Gamez, Sean G. Byars, Adam Greenstein, Maciej Glyda, Anthony M. Heagerty, Michelle C. Maier, Priscilla R. Prestes, Andrzej Antczak, Fadi J. Charchar, Xiao Jiang, Joanna Zywiec, Andrew P. Morris, Matthew Denniff, Bernard Keavney, Gosia Trynka, David Scannali, Xiaoguang Xu, Paweł Bogdański, Adrian S. Woolf, Alicja Nazgiewicz, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, James Eales, Bryan Williams, Tomasz J. Guzik, Nilesh J. Samani, Robert Król, Sushant Saluja, and Monika Szulińska
- Subjects
Male ,ACE2 ,Lung/metabolism ,030204 cardiovascular system & hematology ,Kidney ,Renin-Angiotensin System ,0302 clinical medicine ,Diuretics/pharmacology ,Antihypertensive treatment ,Rats, Inbred SHR ,AcademicSubjects/MED00200 ,Estimated glomerular filtration rate ,0303 health sciences ,Angiotensin Receptor Antagonists ,biology ,Hypertension/drug therapy ,Age Factors ,Antihypertensive Agents/pharmacology ,Middle Aged ,Angiotensin-Converting Enzyme 2/genetics ,medicine.anatomical_structure ,Transcriptome/drug effects ,Hypertension ,Angiotensin-converting enzyme 2 ,COVID-19/complications ,Female ,Angiotensin-Converting Enzyme 2 ,Cardiology and Cardiovascular Medicine ,hormones, hormone substitutes, and hormone antagonists ,Glomerular Filtration Rate ,Adult ,medicine.medical_specialty ,Renal function ,Angiotensin Receptor Antagonists/pharmacology ,Angiotensin-Converting Enzyme Inhibitors/pharmacology ,03 medical and health sciences ,Sex Factors ,Clinical Research ,Internal medicine ,Renin–angiotensin system ,medicine ,Animals ,Humans ,030304 developmental biology ,Aged ,Lung ,business.industry ,SARS-CoV-2 ,Sequence Analysis, RNA ,Gene Expression Profiling ,COVID-19 ,Kidney Tubules/metabolism ,Angiotensin-converting enzyme ,Rats ,Endocrinology ,Blood pressure ,Renin-Angiotensin System/drug effects ,biology.protein ,Adrenergic beta-Antagonists/pharmacology ,Transcriptome ,business - Abstract
Aims Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2)—the cause of coronavirus disease 2019 (COVID-19). However, the effect of renin-angiotensin system (RAS)-inhibition on ACE2 expression in human tissues of key relevance to blood pressure regulation and COVID-19 infection has not previously been reported. Methods and results We examined how hypertension, its major metabolic co-phenotypes, and antihypertensive medications relate to ACE2 renal expression using information from up to 436 patients whose kidney transcriptomes were characterized by RNA-sequencing. We further validated some of the key observations in other human tissues and/or a controlled experimental model. Our data reveal increasing expression of ACE2 with age in both human lungs and the kidney. We show no association between renal expression of ACE2 and either hypertension or common types of RAS inhibiting drugs. We demonstrate that renal abundance of ACE2 is positively associated with a biochemical index of kidney function and show a strong enrichment for genes responsible for kidney health and disease in ACE2 co-expression analysis. Conclusion Our results indicate that neither hypertension nor antihypertensive treatment is likely to alter the expression of the key entry receptor for SARS-CoV-2 in the human kidney. Our data further suggest that in the absence of SARS-CoV-2 infection, kidney ACE2 is most likely nephro-protective but the age-related increase in its expression within lungs and kidneys may be relevant to the risk of SARS-CoV-2 infection., Graphical Abstract Graphical Abstract
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- 2020
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86. Why Polish patients use vitamin drips services: results of a preliminary cross-sectional survey
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Monika Soczewka, Mikołaj Kamiński, Matylda Kręgielska-Narożna, and Paweł Bogdański
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Vitamin ,Cross-sectional study ,business.industry ,MEDLINE ,Vitamins ,chemistry.chemical_compound ,Cross-Sectional Studies ,chemistry ,Environmental health ,Internal Medicine ,Vitamin D and neurology ,Humans ,Medicine ,Poland ,Vitamin D ,business - Published
- 2020
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87. Metabolic Health in Obese Subjects-Is There a Link to Lactoferrin and Lactoferrin Receptor-Related Gene Polymorphisms?
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Edyta Mądry, Joanna Bajerska, Nina Kaczmarek, Jarosław Walkowiak, Patrycja Krzyżanowska-Jankowska, Matylda Kręgielska-Narożna, Paweł Bogdański, and Małgorzata Jamka
- Subjects
Male ,medicine.medical_specialty ,obesity ,Genotype ,030209 endocrinology & metabolism ,Single-nucleotide polymorphism ,lcsh:TX341-641 ,Receptors, Cell Surface ,030204 cardiovascular system & hematology ,Polymorphism, Single Nucleotide ,Article ,03 medical and health sciences ,0302 clinical medicine ,single nucleotide polymorphism ,Internal medicine ,Metabolically healthy obesity ,medicine ,Humans ,Genetic Predisposition to Disease ,low-density lipoprotein receptor-related protein 2 ,low-density lipoprotein receptor-related protein 1 ,Aged ,Nutrition and Dietetics ,biology ,business.industry ,Lactoferrin ,Middle Aged ,medicine.disease ,Obesity ,Genotype frequency ,lactoferrin ,Endocrinology ,biology.protein ,Female ,Metabolic syndrome ,business ,Body mass index ,lcsh:Nutrition. Foods and food supply ,Food Science ,Lipoprotein - Abstract
This study aimed to evaluate the association of genetic variants in lactoferrin (LTF) metabolism-related genes with the prevalence of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). In total, 161 MHO and 291 MUHO subjects were recruited to the study. The following polymorphisms were genotyped: low-density lipoprotein receptor-related protein (LRP) 2 rs2544390, LRP1 rs4759277, LRP1 rs1799986, LTF rs1126477, LTF rs2239692 and LTF rs1126478. We found significant differences in the genotype frequencies of LTF rs2239692 between MHO and MUHO subjects, with the CT variant associated with lower odds of developing metabolic syndrome than the TT variant. In the total population, significant differences in body weight and waist circumference (WC) were identified between LTF rs1126477 gene variants. A similar association with WC was observed in MUHO subjects, while significant differences in body mass index and low-density lipoprotein cholesterol levels were discovered between LTF rs1126477 gene variants in MHO subjects. Besides, there were significant differences in diastolic blood pressure between LRP1 rs1799986 gene variants in MUHO subjects, as well as in WC and high-density lipoprotein cholesterol levels between LRP1 rs4759277 gene variants in MHO subjects. In conclusion, selected lactoferrin and lactoferrin receptor-related gene variants may be associated with the prevalence of metabolically healthy or metabolically unhealthy obesity.
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- 2020
88. Hypertension and renin-angiotensin system blockers are not associated with expression of Angiotensin Converting Enzyme 2 (ACE2) in the kidney
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Monika Szulińska, Nilesh J. Samani, Robert Król, Wojciech Wystrychowski, Michelle C. Maier, James Eales, Fadi J. Charchar, Joanna Zywiec, Adrian S. Woolf, Andrew P. Morris, Ewa Zukowska-Szczechowska, Priscilla R. Prestes, Sushant Saluja, Maciej Tomaszewski, Tomasz J. Guzik, Eddie Cano-Gamez, Bernard Keavney, Maciej Glyda, Louise M Burrell, Xiaoguang Xu, Stephen Harrap, Paweł Bogdański, Anthony M. Heagerty, Sean G. Byars, Alicja Nazgiewicz, Bryan Williams, Xiao Jiang, Andrzej Antczak, Adam Greenstein, Matthew Denniff, Gosia Trynka, and David Scannali
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medicine.medical_specialty ,Kidney ,business.industry ,Renal function ,Disease ,Transcriptome ,Endocrinology ,Blood pressure ,medicine.anatomical_structure ,Internal medicine ,Angiotensin-converting enzyme 2 ,Renin–angiotensin system ,medicine ,business ,Gene ,hormones, hormone substitutes, and hormone antagonists - Abstract
Angiotensin converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2) - the cause of COVID-19 disease. It has been hypothesized that use of renin-angiotensin system (RAS) inhibiting medications in patients with hypertension, increases the expression of ACE2 and thereby increases the risk of COVID-19 infection and severe outcomes or death. However, the effect of RAS-inhibition on ACE2 expression in human tissues of key relevance to blood pressure regulation and COVID-19 infection has not previously been reported. We examined how hypertension, its major metabolic co-phenotypes and antihypertensive medications relate to ACE2 renal expression using information from up to 436 patients whose kidney transcriptomes were characterised by RNA-sequencing. We further validated some of the key observations in other human tissues and/or a controlled experimental model. Our data reveal increasing expression of ACE2 with age in both human lungs and the kidney. We show no association between renal expression of ACE2 and either hypertension or common types of RAS inhibiting drugs. We demonstrate that renal abundance of ACE2 is positively associated with a biochemical index of kidney function and show a strong enrichment for genes responsible for kidney health and disease in ACE2 co-expression analysis. Collectively, our data indicate that neither hypertension nor antihypertensive treatment are likely to alter individual risk of SARS-CoV-2 infection or influence clinical outcomes in COVID-19 through changes of ACE2 expression. Our data further suggest that in the absence of SARS-CoV-2 infection, kidney ACE2 is most likely nephro-protective but the age-related increase in its expression within lungs and kidneys may be relevant to the risk of SARS-CoV-2 infection.
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- 2020
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89. Seasonal variation in lifestyle behavior in Poland: Google searches and market sales analysis
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Paweł Bogdański, Mikołaj Kamiński, and Matylda Kręgielska-Narożna
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medicine.medical_specialty ,Index (economics) ,Consumption ,Google trends ,Psychological intervention ,Population health ,Running ,Weight loss ,Environmental health ,medicine ,Animals ,Humans ,Life Style ,Consumption (economics) ,Cigarettes ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Commerce ,food and beverages ,Seasonality ,medicine.disease ,Lifestyle ,Sales ,Diet ,Search Engine ,Poland ,Seasons ,Biostatistics ,medicine.symptom ,Public aspects of medicine ,RA1-1270 ,business ,Alcohol ,Research Article - Abstract
Background Detection of the seasonal patterns of healthy and unhealthy behavior could be helpful for designing individual and population health interventions programs. This study investigates the seasonal variation in sales of common types of products in Poland and Polish Google queries related to healthy behavior. Methods Data of index sales from a large Polish retail store franchise, from January 2014 to August 2019, has been analyzed. The commercial data included twelve types of products. The interest of Google users was investigated using Google Trends statistics for the same period for six lifestyle-related topics. The seasonality was checked using time series analysis. Results Six of the consumer goods (dairy, ready-made meals, salty snacks, meats, beer, and cigarettes) were most commonly purchased in summer months, four (processed fish, food fats, wine, and alcohol 30%+) in December, and two (bread and sweets) in October. The lowest sales indexes were observed mostly in February. The interest in four topics that have been analyzed (“Diet,” “Dietitian,” “Weight loss,” and “Gym”), was highest in January, while interest in “Dietary supplements” was high in February, and “Running” in May. The search volume of the Google topics were the lowest in December. Conclusion The purchase of food, drinks, and cigarettes, and the interest in information regarding different components of a healthy lifestyle has seasonal variation. New Year and Lent might be good periods to encourage healthy behavior. The motivation may decrease in summer and during Christmas.
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- 2020
90. Effect of sleep duration on blood pressure in women over 55 years of age - Poznan Cohort study
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Remigiusz, Domin, Karolina, Owsik, Urszula, Szybowicz, Katarzyna, Sochacka, Małgorzata, Mirr, Maciej, Spałek, Damian, Skrypnik, Paweł, Bogdański, and Maciej, Owecki
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Cohort Studies ,Cross-Sectional Studies ,Hypertension ,Humans ,Blood Pressure ,Female ,Middle Aged ,Sleep - Abstract
Hypertension is considered to be the most common pathology of the circulatory system and the most common cause of death or cardiovascular diseases' development. There are many commonly known risk factors of this condition, such as overweight, obesity, a high-fat diet, family history of ischemic heart disease, lipid disorders, and atherosclerosis. In order to reduce the effect of high blood pressure, patients should modify their lifestyle, including sleeping patterns. We wanted to investigate if, in a group of women over 55 years of age compared to the general population from Poznan cohort, sleep duration is related to hypertension.All subjects were divided into three research groups depending on the time of sleep. The first group included people who have been sleeping less than 6 hours a day. The second group included people who have been sleeping from 6 to 9 hours a day. The third group was characterized by people with sleep time over 9 hours a day. Due to their age, participants were divided into two groups, below and over 55 years of age.There is a weak positive correlation between long sleep duration (9h) and a higher prevalence of unregulated blood pressure (r = 0.3, p = 0.017) in the group of women over 55 years of age.Unregulated increased blood pressure may occur more frequently in postmenopausal women whose sleep duration exceeds 9 hours a day.
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- 2020
91. Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics
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Joanna Suliburska, Magdalena Sobieska, Katarzyna Skrypnik, and Paweł Bogdański
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Male ,Peptide Hormones ,ved/biology.organism_classification_rank.species ,Pharmaceutical Science ,Analytical Chemistry ,law.invention ,Probiotic ,0302 clinical medicine ,Lactobacillus acidophilus ,iron ,law ,Drug Discovery ,Homocysteine ,0303 health sciences ,biology ,Chemistry ,Lactoferrin ,food and beverages ,Erythroferrone ,divalent metal transporter 1 ,Liver ,Chemistry (miscellaneous) ,Molecular Medicine ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Article ,lcsh:QD241-441 ,03 medical and health sciences ,lcsh:Organic chemistry ,Hepcidins ,Hepcidin ,Internal medicine ,erythroferrone ,medicine ,Animals ,Physical and Theoretical Chemistry ,Rats, Wistar ,030304 developmental biology ,Bifidobacterium bifidum ,ved/biology ,Probiotics ,Organic Chemistry ,Lactococcus lactis ,biology.organism_classification ,transferrin receptor ,Rats ,Ferritin ,Endocrinology ,Dietary Supplements ,Ferritins ,biology.protein ,probiotic supplementation ,hepcidin - Abstract
The influence of probiotic supplementation on iron metabolism remains poorly investigated. However, a range of studies, especially on Lactobacillus plantarum 299v (Lp229v), have indicated a possible positive impact of probiotics on iron absorption. The aim of the study was to determine the effect of multistrain probiotic supply on iron balance. Thirty Wistar rats were randomized into three groups: placebo (KK group), and multistrain probiotic per os in a daily dose of 2.5 ×, 109 colony forming units (CFU) (PA group) or 1 ×, 1010 CFU (PB group). Multistrain probiotic consisted of nine bacterial strains: Bifidobacterium bifidum W23, B. lactis W51, B. lactis W52, Lactobacillus acidophilus W37, L. brevis W63, L. casei W56, L. salivarius W24, Lactococcus lactis W19, and Lc. lactis W58, in equal proportions. After six weeks, blood and organ samples were collected. No differences were found between the three groups in terms of serum concentrations of hepcidin (HEPC), lactoferrin (LTF), homocysteine (HCY), ferritin (Ft), or erythroferrone (ErFe), or in liver content of divalent metal transporter 1 (DMT1), transferrin receptors 1 and 2 (TfR), or ZRT/IRT-like protein 14 (ZIP14) proteins. In the overall sample, positive correlations were noted between the serum concentrations of hepcidin and lactoferrin, and hepcidin and ferritin, serum concentration of hepcidin and DMT1 and TfR1 in the liver, and serum concentration of erythroferrone and TfR2 in the liver. The correlations of serum hepcidin and erythroferrone with liver DMT1 and TfR represent significant mechanisms of Fe homeostasis. Our study has shown that multistrain probiotic supplementation used in the experiment did not disrupt the biochemical and hepatic regulatory processes of Fe balance and did not demonstrate significant influence on selected parameters of Fe metabolism.
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- 2020
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92. You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review
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Monika Szulińska, Małgorzata Moszak, and Paweł Bogdański
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0301 basic medicine ,obesity ,Mediterranean diet ,Western-style diet ,Physiology ,030209 endocrinology & metabolism ,lcsh:TX341-641 ,Review ,Type 2 diabetes ,Gut flora ,Inflammatory bowel disease ,digestive system ,Energy homeostasis ,Bile Acids and Salts ,Eating ,03 medical and health sciences ,0302 clinical medicine ,Metabolic Diseases ,medicine ,Homeostasis ,Humans ,metabolic disorders ,Nutritional Physiological Phenomena ,Nutrition and Dietetics ,biology ,gut microbiota ,diabetes ,vegetarian ,dyslipidemia ,Inflammatory Bowel Diseases ,Lipid Metabolism ,medicine.disease ,biology.organism_classification ,Obesity ,Gastrointestinal Microbiome ,Celiac Disease ,Glucose ,030104 developmental biology ,Cardiovascular Diseases ,Dysbiosis ,Nervous System Diseases ,Metabolic syndrome ,short-chain fatty acid ,Energy Metabolism ,diet ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
The gut microbiota (GM) is defined as the community of microorganisms (bacteria, archaea, fungi, viruses) colonizing the gastrointestinal tract. GM regulates various metabolic pathways in the host, including those involved in energy homeostasis, glucose and lipid metabolism, and bile acid metabolism. The relationship between alterations in intestinal microbiota and diseases associated with civilization is well documented. GM dysbiosis is involved in the pathogenesis of diverse diseases, such as metabolic syndrome, cardiovascular diseases, celiac disease, inflammatory bowel disease, and neurological disorders. Multiple factors modulate the composition of the microbiota and how it physically functions, but one of the major factors triggering GM establishment is diet. In this paper, we reviewed the current knowledge about the relationship between nutrition, gut microbiota, and host metabolic status. We described how macronutrients (proteins, carbohydrates, fat) and different dietary patterns (e.g., Western-style diet, vegetarian diet, Mediterranean diet) interact with the composition and activity of GM, and how gut bacterial dysbiosis has an influence on metabolic disorders, such as obesity, type 2 diabetes, and hyperlipidemia.
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- 2020
93. The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study
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Paweł Bogdański, Monika Szulińska, Karolina Majewska, Hieronim Jakubowski, and Matylda Kręgielska-Narożna
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medicine.medical_specialty ,obesity ,Homocysteine ,030309 nutrition & dietetics ,Placebo-controlled study ,lcsh:Medicine ,medicine.disease_cause ,Placebo ,Article ,law.invention ,03 medical and health sciences ,Probiotic ,chemistry.chemical_compound ,law ,Internal medicine ,medicine ,030304 developmental biology ,0303 health sciences ,medicine.diagnostic_test ,Triglyceride ,business.industry ,lcsh:R ,General Medicine ,homocysteine ,medicine.disease ,Obesity ,cardiovascular diseases ,Endocrinology ,chemistry ,Lipid profile ,business ,Oxidative stress ,probiotic - Abstract
Dysregulated metabolism of homocysteine (Hcy) is associated with obesity. Supplementation with probiotics can potentially be a natural therapeutic method for metabolic disorders. The precise mechanism in which microbiota affect Hcy metabolism in obese individuals is still unknown. The aim of this study was to evaluate the effects of a 12-week supplementation with a multispecies probiotic on Hcy levels, oxidative stress, inflammation and lipid profile in obese patients. This randomized double-blind placebo-controlled trial was performed on 50 obese women (aged 45&ndash, 70 years). Subjects were randomly assigned to take either a multispecies probiotic supplement (n = 25) or placebo (n = 25) for 12 weeks. The probiotic contained nine bacterial strains containing 2.5 ×, 109 CFU/g. Biochemical and anthropometric measurements were carried out at baseline and after 12 weeks of intervention. At the end of the study, a significant decrease in Hcy, tumor necrosis factor &alpha, (TNF-&alpha, ), total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were observed in the probiotic group. The amelioration of total antioxidant status (TAS) was also observed. The 12-week supplementation of the multispecies probiotic (Ecologic®, BARIER) effectively reduced Hcy concentration, oxidative stress and inflammation, and improved the lipid profile. These multidirectional effects can potentially reduce cardiometabolic risks.
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- 2020
94. Does metabolically healthy obesity exist? A 32-year-old man with BMI 78 kg/m2 - to treat or not to treat?
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Paweł Bogdański, Katarzyna Pastusiak, Wiesław Bryl, Marta Walczak-Gałęzewska, and Agnieszka Ratajczak
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Adult ,Male ,Obesity, Metabolically Benign ,business.industry ,Endocrinology, Diabetes and Metabolism ,Health Status ,Physiology ,Body Mass Index ,Endocrinology ,Risk Factors ,Metabolically healthy obesity ,Medicine ,Humans ,business - Abstract
Not required for Clinical Vignette.
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- 2020
95. Determination of the Popularity of Dietary Supplements Using Google Search Rankings
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Mikołaj Kamiński, Paweł Bogdański, and Matylda Kręgielska-Narożna
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Vitamin ,PubMed ,mineral ,020205 medical informatics ,google trends ,lcsh:TX341-641 ,02 engineering and technology ,Biology ,magnesium ,Article ,dietary supplements ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,iron ,ranking ,Environmental health ,0202 electrical engineering, electronic engineering, information engineering ,Humans ,030212 general & internal medicine ,Micronutrients ,Retrospective Studies ,Nutrition and Dietetics ,Lutein ,vitamin ,Popularity ,Search Engine ,Access to information ,chemistry ,Internet Use ,internet ,protein ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
The internet provides access to information about dietary supplements and allows their easy purchase. We aimed to rank the interest of Google users in dietary supplements and to determine the changes that occurred in their popularity from 2004 to 2019. We used Google Trends to generate data over time on regional interest in dietary supplements (n = 200). We categorized each included supplement and calculated the interest in all topics in proportion to the relative search volume (RSV) of &ldquo, lutein&rdquo, We analyzed the trends over time of all topics and categories. Globally, the topics with the highest popularity were &ldquo, magnesium&rdquo, which was 23.72 times more popular than &ldquo, &ldquo, protein&rdquo, (15.22 times more popular), and &ldquo, iron&rdquo, (15.12). The categories of supplements receiving most interest were protein (9.64), mineral (5.24), and vitamin (3.47). The RSV of seven categories of topics (amino acid, bacterial, botanical, fiber, mineral, protein, and vitamin) increased over time while two categories (enzyme and fat or fatty acid) saw a drop in their RSV. Overall, 119 topics saw an increase in interest over time, 19 remained stable, and 62 saw interest in them decrease. Google Trends provides insights into e-discourse and enables analysis of the differences in popularity of certain topics across countries and over time.
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- 2020
96. Association of rs699947 (−2578 C/A) and rs2010963 (−634 G/C) Single Nucleotide Polymorphisms of the VEGF Gene, VEGF-A and Leptin Serum Level, and Cardiovascular Risk in Patients with Excess Body Mass: A Case–Control Study
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Paweł P. Jagodziński, Damian Skrypnik, Adrianna Mostowska, and Paweł Bogdański
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cardiovascular risk ,medicine.medical_specialty ,obesity ,lcsh:Medicine ,Single-nucleotide polymorphism ,030204 cardiovascular system & hematology ,leptin ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Gene expression ,Genotype ,medicine ,030304 developmental biology ,0303 health sciences ,vascular endothelial growth factor ,business.industry ,VEGF gene polymorphism ,Leptin ,lcsh:R ,Case-control study ,General Medicine ,medicine.disease ,Obesity ,Vascular endothelial growth factor ,Endocrinology ,chemistry ,Arterial stiffness ,business - Abstract
Background: Two single nucleotide polymorphisms (SNPs) of the VEGF gene, rs699947 and rs2010963, are responsible for differentiated gene expression. A mutual dependence between VEGF and leptin serum level has been observed. This study investigated the associations between the rs699947 and rs2010963 SNPs of VEGF gene, VEGF-A, and leptin serum concentrations, and cardiometabolic risk of body mass excess. Methods: In this case−control study, 212 subjects with excess body mass and 145 normal-weight controls gave blood samples and underwent anthropometric and pulse wave analysis. Genotyping of VEGF gene was carried out to analyze the rs699947 (−2578 C/A) and rs2010963 (−634 G/C) SNPs. (ClinicalTrials.gov ID: NCT04077554). Results: This study showed a significant positive correlation between serum levels of VEGF-A and leptin in individuals with excess body mass possessing the CC genotype of the rs699947 variant of the VEGF gene. It has been registered that an increase in VEGF-A serum level correlates with an increase in arterial stiffness in excess body mass patients harboring AA genotype of the rs699947 (−2578 C/A) variant of the VEGF gene. No differences in VEGF-A and leptin serum concentrations were noted between particular genotypes. Conclusions: The CC genotype of the rs699947 variant of the VEGF gene promotes a positive interdependency between leptin and VEGF-A serum levels in subjects with excess body mass.
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- 2020
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97. Cardiovascular Function in Obstructive Sleep Apnea Patients with Controlled Hypertension
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Magdalena, Kostrzewska, Marcin, Grabicki, Tomasz, Piorunek, Tomasz, Krauze, Damian, Skrypnik, Halina, Batura-Gabryel, Tomasz, Trafas, Paweł, Bogdański, Andrzej, Wykrętowicz, and Przemysław, Guzik
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Male ,Sleep Apnea, Obstructive ,Polysomnography ,Hypertension ,Hemodynamics ,Humans ,Blood Pressure ,Obesity ,Middle Aged ,Body Mass Index - Abstract
This study investigated hemodynamic characteristics of obstructive sleep apnea (OSA) accompanied by hypertensive disease in obese men, in whom blood pressure was pharmacologically controlled within the normal range, not exceeding 140/90 mmHg. There were 21 severe OSA patients (mean age 54.1 ± 9.3 years, apnea-hypopnea index of 47.1 ± 18.8 episodes per hour) included in the study, in whom OSA was diagnosed with polysomnography. The control group consisted of healthy normotensive age-matched subjects. Hemodynamic profile was recorded nonivasively with impedance cardiography. Brachial blood pressure and radial artery tonometry were performed to capture and reconstruct peripheral radial and central aortic pressure waveforms in both groups of subjects. Compared to healthy men, OSA patients had a significantly higher body mass index (BMI); the mean increase in BMI amounted to 6.4 ± 1.2 kg/m
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- 2020
98. Cardiovascular Function in Obstructive Sleep Apnea Patients with Controlled Hypertension
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Halina Batura-Gabryel, Damian Skrypnik, Andrzej Wykretowicz, Tomasz Trafas, Marcin Grabicki, Magdalena Kostrzewska, Paweł Bogdański, Przemysław Guzik, Tomasz Piorunek, and Tomasz Krauze
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Hemodynamics ,Polysomnography ,medicine.disease ,respiratory tract diseases ,Pulse pressure ,Obstructive sleep apnea ,Impedance cardiography ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Internal medicine ,Heart rate ,medicine ,Aortic pressure ,Cardiology ,030212 general & internal medicine ,business - Abstract
This study investigated hemodynamic characteristics of obstructive sleep apnea (OSA) accompanied by hypertensive disease in obese men, in whom blood pressure was pharmacologically controlled within the normal range, not exceeding 140/90 mmHg. There were 21 severe OSA patients (mean age 54.1 ± 9.3 years, apnea-hypopnea index of 47.1 ± 18.8 episodes per hour) included in the study, in whom OSA was diagnosed with polysomnography. The control group consisted of healthy normotensive age-matched subjects. Hemodynamic profile was recorded nonivasively with impedance cardiography. Brachial blood pressure and radial artery tonometry were performed to capture and reconstruct peripheral radial and central aortic pressure waveforms in both groups of subjects. Compared to healthy men, OSA patients had a significantly higher body mass index (BMI); the mean increase in BMI amounted to 6.4 ± 1.2 kg/m2. The patients also presented significant differences in the hemodynamic profile. The difference consisted of a faster heart rate, higher peripheral pulse pressure, and reduced blood flow acceleration and velocity indices, describing myocardial contractility. Notably, the significance of hemodynamic differences in OSA patients disappeared in the analysis adjusted for the outstanding increase in BMI. In conclusion, the findings strongly suggest that obesity rather than the hypertensive disease per se is a source of hemodynamic consequences in OSA patients.
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- 2020
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99. RAPORT MEDYCZNEJ RACJI STANU: WARTOŚCI W MEDYCYNIE-CZEGO UCZY NAS ŚWIATOWY KRYZYS ZDROWIA. REPORT: VALUES IN MEDICINE-WHAT THE WORLD HEALTH CRISIS TEACHES US
- Author
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Gierczyński, Jakub, Latos-Bieleńska, Anna, Paweł Bogdański, Borkowski, Leszek, Błażewicz, Grzegorz, Chudecka-Głaz, Anita, Czech, Marcin, Czupryniak, Leszek, Paweł Kowal, Kraska, Waldemar, Paweł Krawczyk, Krzakowski, Maciej, Kwiatkowska, Brygida, Kupiecka, Anna, Kurzyna, Marcin, Latos, Tomasz, Małecka-Libera, Beata, Łanda, Krzysztof, Lech-Maranda, Ewa, Meder, Janusz, Mierzejewski, Piotr, Milczewska, Justyna, Niedzielski, Adam, Nojszewska, Ewelina, Nowak, Filip, Nycz, Kazimierz, Jarosław Pinkas, Prusak, Jacek, Kostera-Pruszczyk, Anna, Ruciński, Kacper, Samselska, Dagmara, Schymalla, Iwona, Małgorzata Gałązka-Sobotka, Michał Sutkowski, Rafał Stec, Śliwińska, Anna, Topór-Mądry, Roman, Wechmann, Krystyna, Paweł Wójtowicz, and Żuber, Zbigniew
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- 2020
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100. RAPORT MEDYCZNEJ RACJI STANU: SYTUACJA CHORYCH NA CHOROBY METABOLICZNE W CZASIE PANDEMII KORONAWIRUSA SARS- COV-2. REPORT: THE SITUATION OF PATIENTS WITH METABOLIC DISEASES DURING THE SARS-COV-2 CORONAVIRUS PANDEMIC
- Author
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Gierczyński, Jakub, Paweł Bogdański, Czupryniak, Leszek, Gaciąg, Zbigniew, Hoffman, Piotr, Jasinska, Anna, Paweł Kowal, Meder, Janusz, Mierzejewski, Piotr, Niedzielski, Adam, Parkitna, Joanna, Pruszczyk, Piotr, Samochowiec, Jerzy, Michał Sutkowski, Wernik, Agnieszka, Wyleżoł, Mariusz, and Zozulińska-Ziółkiewicz, Dorota
- Published
- 2020
- Full Text
- View/download PDF
Catalog
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