2,942 results on '"Paul M, Thompson"'
Search Results
52. Lifestyle Factors That Promote Brain Structural Resilience in Individuals with Genetic Risk Factors for Dementia.
- Author
-
Elizabeth Haddad, Shayan Javid, Nikhil J. Dhinagar, Alyssa H. Zhu, Pradeep Lam, Iyad Ba Gari, Arpana Gupta, Paul M. Thompson, Talia M. Nir, and Neda Jahanshad
- Published
- 2022
- Full Text
- View/download PDF
53. Predicting Spatio-Temporal Human Brain Response Using fMRI.
- Author
-
Chongyue Zhao, Liang Zhan, Paul M. Thompson, and Heng Huang
- Published
- 2022
- Full Text
- View/download PDF
54. Explainable Contrastive Multiview Graph Representation of Brain, Mind, and Behavior.
- Author
-
Chongyue Zhao, Liang Zhan, Paul M. Thompson, and Heng Huang
- Published
- 2022
- Full Text
- View/download PDF
55. Towards Sparsified Federated Neuroimaging Models via Weight Pruning.
- Author
-
Dimitris Stripelis, Umang Gupta, Nikhil J. Dhinagar, Greg Ver Steeg, Paul M. Thompson, and José Luis Ambite
- Published
- 2022
- Full Text
- View/download PDF
56. Learning Interpretable Regularized Ordinal Models from 3D Mesh Data for Neurodegenerative Disease Staging.
- Author
-
Yuji Zhao, Max A. Laansma, Eva M. van Heese, Conor Owens-Walton, Laura M. Parkes, Ines Debove, Christian Rummel, Roland Wiest, Fernando Cendes, Rachel Guimaraes, Clarissa Lin Yasuda, Jiun-Jie Wang, Tim J. Anderson, John C. Dalrymple-Alford, Tracy R. Melzer, Toni L. Pitcher, Reinhold Schmidt, Petra Schwingenschuh, Gaëtan Garraux, Mario Rango, Letizia Squarcina, Sarah Al-Bachari, Hedley C. A. Emsley, Johannes C. Klein, Clare E. Mackay, Michiel F. Dirkx, Rick C. Helmich, Francesca Assogna, Fabrizio Piras, Joanna K. Bright, Gianfranco Spalletta, Kathleen Poston, Christine Lochner, Corey T. McMillan, Daniel Weintraub, Jason Druzgal, Benjamin Newman, Odile A. van den Heuvel, Neda Jahanshad, Paul M. Thompson, Ysbrand D. van der Werf, and Boris Gutman
- Published
- 2022
- Full Text
- View/download PDF
57. Revealing Continuous Brain Dynamical Organization with Multimodal Graph Transformer.
- Author
-
Chongyue Zhao, Liang Zhan, Paul M. Thompson, and Heng Huang
- Published
- 2022
- Full Text
- View/download PDF
58. The Impact of Susceptibility Distortion Correction Protocols on Adolescent Diffusion MRI Measures.
- Author
-
Talia M. Nir, Julio E. Villalon-Reina, Paul M. Thompson, and Neda Jahanshad
- Published
- 2022
- Full Text
- View/download PDF
59. ENIGMA, big data, and the human brain: worldwide neuroimaging & genomics of 30 brain diseases in 100, 000 people from 45 countries (Conference Presentation).
- Author
-
Paul M. Thompson
- Published
- 2023
- Full Text
- View/download PDF
60. A practical Alzheimer’s disease classifier via brain imaging-based deep learning on 85,721 samples
- Author
-
Bin Lu, Hui-Xian Li, Zhi-Kai Chang, Le Li, Ning-Xuan Chen, Zhi-Chen Zhu, Hui-Xia Zhou, Xue-Ying Li, Yu-Wei Wang, Shi-Xian Cui, Zhao-Yu Deng, Zhen Fan, Hong Yang, Xiao Chen, Paul M. Thompson, Francisco Xavier Castellanos, and Chao-Gan Yan
- Subjects
Alzheimer’s disease ,Convolutional neural network ,Magnetic resonance brain imaging ,Sex differences ,Transfer learning ,Computer engineering. Computer hardware ,TK7885-7895 ,Information technology ,T58.5-58.64 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Abstract Beyond detecting brain lesions or tumors, comparatively little success has been attained in identifying brain disorders such as Alzheimer’s disease (AD), based on magnetic resonance imaging (MRI). Many machine learning algorithms to detect AD have been trained using limited training data, meaning they often generalize poorly when applied to scans from previously unseen scanners/populations. Therefore, we built a practical brain MRI-based AD diagnostic classifier using deep learning/transfer learning on a dataset of unprecedented size and diversity. A retrospective MRI dataset pooled from more than 217 sites/scanners constituted one of the largest brain MRI samples to date (85,721 scans from 50,876 participants) between January 2017 and August 2021. Next, a state-of-the-art deep convolutional neural network, Inception-ResNet-V2, was built as a sex classifier with high generalization capability. The sex classifier achieved 94.9% accuracy and served as a base model in transfer learning for the objective diagnosis of AD. After transfer learning, the model fine-tuned for AD classification achieved 90.9% accuracy in leave-sites-out cross-validation on the Alzheimer’s Disease Neuroimaging Initiative (ADNI, 6,857 samples) dataset and 94.5%/93.6%/91.1% accuracy for direct tests on three unseen independent datasets (AIBL, 669 samples / MIRIAD, 644 samples / OASIS, 1,123 samples). When this AD classifier was tested on brain images from unseen mild cognitive impairment (MCI) patients, MCI patients who converted to AD were 3 times more likely to be predicted as AD than MCI patients who did not convert (65.2% vs. 20.6%). Predicted scores from the AD classifier showed significant correlations with illness severity. In sum, the proposed AD classifier offers a medical-grade marker that has potential to be integrated into AD diagnostic practice.
- Published
- 2022
- Full Text
- View/download PDF
61. Genetic map of regional sulcal morphology in the human brain from UK biobank data
- Author
-
Benjamin B. Sun, Stephanie J. Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N. Painter, Christopher N. Foley, Biogen Biobank Team, Megan E. Jensen, Donald G. McLaren, Sai Spandana Chintapalli, Alyssa H. Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E. Medland, Paul M. Thompson, Neda Jahanshad, and Christopher D. Whelan
- Subjects
Science - Abstract
Genetic associations with particular patterns of brain folding may provide insight into brain development and function. Here, the authors identify and replicate 388 genetic associations with brain sulcal morphology across 40,169 UK Biobank MRI scans, revealing insights into the processes guiding cortical development and genetic correlations with neuropsychiatric phenotypes.
- Published
- 2022
- Full Text
- View/download PDF
62. Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
- Author
-
Bo-yong Park, Valeria Kebets, Sara Larivière, Meike D. Hettwer, Casey Paquola, Daan van Rooij, Jan Buitelaar, Barbara Franke, Martine Hoogman, Lianne Schmaal, Dick J. Veltman, Odile A. van den Heuvel, Dan J. Stein, Ole A. Andreassen, Christopher R. K. Ching, Jessica A. Turner, Theo G. M. van Erp, Alan C. Evans, Alain Dagher, Sophia I. Thomopoulos, Paul M. Thompson, Sofie L. Valk, Matthias Kirschner, and Boris C. Bernhardt
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Individuals across six major psychiatric conditions from the ENIGMA consortium reveals a shared morphological effect, following a sensory-fugal axis, which is related to microstructural gradient and neurotransmitter axes.
- Published
- 2022
- Full Text
- View/download PDF
63. Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data
- Author
-
Hung Mai, Jingxuan Bao, Paul M. Thompson, Dokyoon Kim, and Li Shen
- Subjects
Genetic variation ,Gene expression ,Brain imaging ,Imaging genomic association ,Brain volume ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Brain volume has been widely studied in the neuroimaging field, since it is an important and heritable trait associated with brain development, aging and various neurological and psychiatric disorders. Genome-wide association studies (GWAS) have successfully identified numerous associations between genetic variants such as single nucleotide polymorphisms and complex traits like brain volume. However, it is unclear how these genetic variations influence regional gene expression levels, which may subsequently lead to phenotypic changes. S-PrediXcan is a tissue-specific transcriptomic data analysis method that can be applied to bridge this gap. In this work, we perform an S-PrediXcan analysis on GWAS summary data from two large imaging genetics initiatives, the UK Biobank and Enhancing Neuroimaging Genetics through Meta Analysis, to identify tissue-specific transcriptomic effects on two closely related brain volume measures: total brain volume (TBV) and intracranial volume (ICV). Results As a result of the analysis, we identified 10 genes that are highly associated with both TBV and ICV. Nine out of 10 genes were found to be associated with TBV in another study using a different gene-based association analysis. Moreover, most of our discovered genes were also found to be correlated with multiple cognitive and behavioral traits. Further analyses revealed the protein–protein interactions, associated molecular pathways and biological functions that offer insight into how these genes function and interact with others. Conclusions These results confirm that S-PrediXcan can identify genes with tissue-specific transcriptomic effects on complex traits. The analysis also suggested novel genes whose expression levels are related to brain volumetric traits. This provides important insights into the genetic mechanisms of the human brain.
- Published
- 2022
- Full Text
- View/download PDF
64. Spy in the sky: a method to identify pregnant small cetaceans
- Author
-
Barbara J. Cheney, Julian Dale, Paul M. Thompson, and Nicola J. Quick
- Subjects
bottlenose dolphin ,cetacean ,photogrammetry ,pregnancy status ,UAS ,UAV ,Technology ,Ecology ,QH540-549.5 - Abstract
Abstract Data on sex ratios, age classes, reproductive success and health status are key metrics to manage populations, yet can be difficult to collect in wild cetacean populations. Long‐term individual‐based studies provide a unique opportunity to apply unoccupied aerial system (UAS) photogrammetry to non‐invasively measure body morphometrics of individuals with known life history information. The aims of this study were (1) to compare length measurements from UAS photogrammetry with laser photogrammetry and (2) to explore whether UAS measurements of body width could be used to remotely determine pregnancy status, sex or age class in a well‐studied bottlenose dolphin population in Scotland. We carried out five boat‐based surveys in July and August 2017, with concurrent photo‐identification, UAS and laser photogrammetry. Photographs were measured using bespoke programmes, MorphMetriX for UAS photos and a Zooniverse project for laser photos. In total 64 dolphins were identified using photo‐ID, 54 of which had concurrent UAS body length and 47 with laser body length measurements. We also measured body widths at 10% increments from 10% to 90% of body length for 48 individuals of known sex, age class and/or pregnancy status. There was no significant difference in the length of individuals measured with UAS and laser photogrammetry. Discriminant analyses of the body width–length (WL) ratios expected to change during pregnancy, correctly assigned pregnancy status for 14 of the 15 females of known pregnancy status. Only one pregnant female was incorrectly assigned as not pregnant. However, our results showed that length and body width cannot accurately allocate these bottlenose dolphins to sex or age class using photogrammetry techniques alone. The present study illustrates that UAS and laser photogrammetry measurements are comparable for small cetaceans and demonstrates that UAS measurements of body WL ratio can accurately assign pregnancy status in bottlenose dolphins.
- Published
- 2022
- Full Text
- View/download PDF
65. Local molecular and global connectomic contributions to cross-disorder cortical abnormalities
- Author
-
Justine Y. Hansen, Golia Shafiei, Jacob W. Vogel, Kelly Smart, Carrie E. Bearden, Martine Hoogman, Barbara Franke, Daan van Rooij, Jan Buitelaar, Carrie R. McDonald, Sanjay M. Sisodiya, Lianne Schmaal, Dick J. Veltman, Odile A. van den Heuvel, Dan J. Stein, Theo G. M. van Erp, Christopher R. K. Ching, Ole A. Andreassen, Tomas Hajek, Nils Opel, Gemma Modinos, André Aleman, Ysbrand van der Werf, Neda Jahanshad, Sophia I. Thomopoulos, Paul M. Thompson, Richard E. Carson, Alain Dagher, and Bratislav Misic
- Subjects
Science - Abstract
Changes to structural and functional connectivity can give rise to neurodegeneration and neurodevelopmental diseases. Here the authors investigate molecular and connectomic patterns in 13 different neurological, psychiatric and neurodevelopmental diseases from the ENIGMA consortium.
- Published
- 2022
- Full Text
- View/download PDF
66. Variation in foraging activity influences area-restricted search behaviour by bottlenose dolphins
- Author
-
Oihane Fernandez-Betelu, Virginia Iorio-Merlo, Isla M. Graham, Barbara J. Cheney, Simone M. Prentice, Rachael Xi Cheng, and Paul M. Thompson
- Subjects
area-restricted search behaviour ,echolocation buzzes ,bray calls ,bottlenose dolphins ,machine learning ,passive acoustics ,Science - Abstract
Area-restricted search (ARS) behaviour is commonly used to characterize spatio-temporal variation in foraging activity of predators, but evidence of the drivers underlying this behaviour in marine systems is sparse. Advances in underwater sound recording techniques and automated processing of acoustic data now provide opportunities to investigate these questions where species use different vocalizations when encountering prey. Here, we used passive acoustics to investigate drivers of ARS behaviour in a population of dolphins and determined if residency in key foraging areas increased following encounters with prey. Analyses were based on two independent proxies of foraging: echolocation buzzes (widely used as foraging proxies) and bray calls (vocalizations linked to salmon predation attempts). Echolocation buzzes were extracted from echolocation data loggers and bray calls from broadband recordings by a convolutional neural network. We found a strong positive relationship between the duration of encounters and the frequency of both foraging proxies, supporting the theory that bottlenose dolphins engage in ARS behaviour in response to higher prey encounter rates. This study provides empirical evidence for one driver of ARS behaviour and demonstrates the potential for applying passive acoustic monitoring in combination with deep learning-based techniques to investigate the behaviour of vocal animals.
- Published
- 2023
- Full Text
- View/download PDF
67. Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
- Author
-
Helen Baldwin, Joaquim Radua, Mathilde Antoniades, Shalaila S. Haas, Sophia Frangou, Ingrid Agartz, Paul Allen, Ole A. Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Cali F. Bartholomeusz, Michael W. L. Chee, Tiziano Colibazzi, Rebecca E. Cooper, Cheryl M. Corcoran, Vanessa L. Cropley, Bjørn H. Ebdrup, Adriana Fortea, Louise Birkedal Glenthøj, Holly K. Hamilton, Kristen M. Haut, Rebecca A. Hayes, Ying He, Karsten Heekeren, Michael Kaess, Kiyoto Kasai, Naoyuki Katagiri, Minah Kim, Jochen Kindler, Mallory J. Klaunig, Shinsuke Koike, Alex Koppel, Tina D. Kristensen, Yoo Bin Kwak, Jun Soo Kwon, Stephen M. Lawrie, Irina Lebedeva, Jimmy Lee, Ashleigh Lin, Rachel L. Loewy, Daniel H. Mathalon, Chantal Michel, Romina Mizrahi, Paul Møller, Barnaby Nelson, Takahiro Nemoto, Dorte Nordholm, Maria A. Omelchenko, Christos Pantelis, Jayachandra M. Raghava, Jan I. Røssberg, Wulf Rössler, Dean F. Salisbury, Daiki Sasabayashi, Ulrich Schall, Lukasz Smigielski, Gisela Sugranyes, Michio Suzuki, Tsutomu Takahashi, Christian K. Tamnes, Jinsong Tang, Anastasia Theodoridou, Sophia I. Thomopoulos, Alexander S. Tomyshev, Peter J. Uhlhaas, Tor G. Værnes, Therese A. M. J. van Amelsvoort, Theo G. M. Van Erp, James A. Waltz, Lars T. Westlye, Stephen J. Wood, Juan H. Zhou, Philip McGuire, Paul M. Thompson, Maria Jalbrzikowski, Dennis Hernaus, Paolo Fusar-Poli, and the ENIGMA Clinical High Risk for Psychosis Working Group
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the ‘normativeness’ of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.
- Published
- 2022
- Full Text
- View/download PDF
68. Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
- Author
-
Sara Larivière, Jessica Royer, Raúl Rodríguez-Cruces, Casey Paquola, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S. Keller, Fernando Cendes, Clarissa L. Yasuda, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K. Focke, Martin Domin, Felix von Podewills, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Terence J. O’Brien, Benjamin Sinclair, Lucy Vivash, Patricia M. Desmond, Elaine Lui, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P. Doherty, Gianpiero L. Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D. Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H. Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Gavin P. Winston, Aoife Griffin, Aditi Singh, Vijay K. Tiwari, Barbara A. K. Kreilkamp, Matteo Lenge, Renzo Guerrini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Bernd Weber, Chantal Depondt, Julie Absil, Sarah J. A. Carr, Eugenio Abela, Mark P. Richardson, Orrin Devinsky, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N. Hatton, Sjoerd B. Vos, Lorenzo Caciagli, John S. Duncan, Christopher D. Whelan, Paul M. Thompson, Sanjay M. Sisodiya, Andrea Bernasconi, Angelo Labate, Carrie R. McDonald, Neda Bernasconi, and Boris C. Bernhardt
- Subjects
Science - Abstract
Epilepsy is a brain network disorder with associated genetic risk factors. Here, the authors show that spatial patterns of transcriptomic vulnerability co-vary with structural brain network alterations in focal and generalized epilepsy.
- Published
- 2022
- Full Text
- View/download PDF
69. MVNet: Multi-Variate Multi-View Brain Network Comparison Over Uncertain Data.
- Author
-
Lei Shi 0002, Junnan Hu, Zhihao Tan, Jun Tao 0002, Jiayan Ding, Yan Jin 0001, Yanjun Wu, and Paul M. Thompson
- Published
- 2022
- Full Text
- View/download PDF
70. ENIGMA + COINSTAC: Improving Findability, Accessibility, Interoperability, and Re-usability.
- Author
-
Jessica A. Turner, Vince D. Calhoun, Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Sophia I. Thomopoulos, Eric Verner, Gregory P. Strauss, Anthony O. Ahmed, Matthew D. Turner, Sunitha Basodi, Judith M. Ford, Daniel H. Mathalon, Adrian Preda, Aysenil Belger, Bryon A. Mueller, Kelvin O. Lim, and Theo G. M. van Erp
- Published
- 2022
- Full Text
- View/download PDF
71. Is Neuroscience FAIR? A Call for Collaborative Standardisation of Neuroscience Data.
- Author
-
Jean-Baptiste Poline, David N. Kennedy, Friedrich T. Sommer, Giorgio A. Ascoli, David C. Van Essen, Adam R. Ferguson, Jeffrey S. Grethe, Michael Hawrylycz, Paul M. Thompson, Russell A. Poldrack, Satrajit S. Ghosh, David B. Keator, Thomas L. Athey, Joshua T. Vogelstein, Helen S. Mayberg, and Maryann E. Martone
- Published
- 2022
- Full Text
- View/download PDF
72. Semi-Synchronous Federated Learning for Energy-Efficient Training and Accelerated Convergence in Cross-Silo Settings.
- Author
-
Dimitris Stripelis, Paul M. Thompson, and José Luis Ambite
- Published
- 2022
- Full Text
- View/download PDF
73. Tackling the dimensions in imaging genetics with CLUB-PLS.
- Author
-
André Altmann, Ana C. Lawry Aguila, Neda Jahanshad, Paul M. Thompson, and Marco Lorenzi
- Published
- 2023
- Full Text
- View/download PDF
74. Video and Synthetic MRI Pre-training of 3D Vision Architectures for Neuroimage Analysis.
- Author
-
Nikhil J. Dhinagar, Amit Singh, Saket Ozarkar, Ketaki Buwa, Sophia I. Thomopoulos, Conor Owens-Walton, Emily Laltoo, Yao-Liang Chen, Philip A. Cook, Corey McMillan, Chih-Chien Tsai, Jiun-Jie Wang, Yih-Ru Wu, and Paul M. Thompson
- Published
- 2023
- Full Text
- View/download PDF
75. Incomplete Multimodal Learning for Complex Brain Disorders Prediction.
- Author
-
Reza Shirkavand, Liang Zhan, Heng Huang, Li Shen 0001, and Paul M. Thompson
- Published
- 2023
- Full Text
- View/download PDF
76. A Surface-Based Federated Chow Test Model for Integrating APOE Status, Tau Deposition Measure, and Hippocampal Surface Morphometry.
- Author
-
Jianfeng Wu, Yi Su, Yanxi Chen, Wenhui Zhu, Eric M. Reiman, Richard J. Caselli, Kewei Chen 0001, Paul M. Thompson, Junwen Wang, and Yalin Wang 0001
- Published
- 2023
- Full Text
- View/download PDF
77. DenseNet and Support Vector Machine classifications of major depressive disorder using vertex-wise cortical features.
- Author
-
Vladimir Belov, Tracy Erwin-Grabner, Ling-Li Zeng, Christopher R. K. Ching, André Aleman, Alyssa R. Amod, Zeynep Basgoze, Francesco Benedetti, Bianca Besteher, Katharina Brosch, Robin Bülow, Romain Colle, Colm G. Connolly, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Kathryn Cullen, Udo Dannlowski, Christopher G. Davey, Annemiek Dols, Jan Ernsting, Jennifer W. Evans, Lukas Fisch, Paola Fuentes-Claramonte, Ali Saffet Gonul, Ian H. Gotlib, Hans Jörgen Grabe, Nynke A. Groenewold, Dominik Grotegerd, Tim Hahn, J. Paul Hamilton, Laura K. M. Han, Ben J. Harrison, Tiffany C. Ho, Neda Jahanshad, Alec J. Jamieson, Andriana Karuk, Tilo Kircher, Bonnie Klimes-Dougan, Sheri-Michelle Koopowitz, Thomas M. Lancaster, Ramona Leenings, Meng Li, David E. J. Linden, Frank P. MacMaster, David M. A. Mehler, Susanne Meinert, Elisa Melloni, Bryon A. Mueller, Benson Mwangi, Igor Nenadic, Amar Ojha, Yasumasa Okamoto, Mardien L. Oudega, Brenda W. J. H. Penninx, Sara Poletti, Edith Pomarol-Clotet, Maria J. Portella, Elena Pozzi, Joaquim Radua, Elena Rodríguez-Cano, Matthew D. Sacchet, Raymond Salvador, Anouk Schrantee, Kang Sim, Jair C. Soares, Aleix Solanes, Dan J. Stein, Frederike Stein, Aleks Stolicyn, Sophia I. Thomopoulos, Yara J. Toenders, Aslihan Uyar-Demir, Eduard Vieta, Yolanda Vives-Gilabert, Henry Völzke, Martin Walter, Heather C. Whalley, Sarah Whittle, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Tony T. Yang, Carlos Zarate, Dick J. Veltman, Lianne Schmaal, Paul M. Thompson, and Roberto Goya-Maldonado
- Published
- 2023
- Full Text
- View/download PDF
78. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
- Author
-
Cees J. Weeland, Selina Kasprzak, Niels T. de Joode, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Vilde Brecke, Silvia Brem, Carolina Cappi, Yuqi Cheng, Kang Ik K. Cho, Daniel L. C. Costa, Sara Dallaspezia, Damiaan Denys, Goi Khia Eng, Sónia Ferreira, Jamie D. Feusner, Martine Fontaine, Jean-Paul Fouche, Rachael G. Grazioplene, Patricia Gruner, Mengxin He, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Hao Hu, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Jose M. Menchón, Luciano Minnuzi, Pedro Silva Moreira, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Ana E. Ortiz, Jose C. Pariente, John Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Helen Blair Simpson, Noam Soreni, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, Jumpei Takahashi, Tais Tanamatis, Jinsong Tang, Anders Lillevik Thorsen, David Tolin, Ysbrand D. van der Werf, Hein van Marle, Guido A. van Wingen, Daniela Vecchio, G. Venkatasubramanian, Susanne Walitza, Jicai Wang, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Qing Zhao, ENIGMA OCD Working Group, Tonya White, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, and Chris Vriend
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered ( https://osf.io/73dvy ) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (
- Published
- 2022
- Full Text
- View/download PDF
79. Improved Brain Age Estimation With Slice-Based Set Networks.
- Author
-
Umang Gupta, Pradeep K. Lam, Greg Ver Steeg, and Paul M. Thompson
- Published
- 2021
- Full Text
- View/download PDF
80. Scaling Neuroscience Research Using Federated Learning.
- Author
-
Dimitris Stripelis, José Luis Ambite, Pradeep Lam, and Paul M. Thompson
- Published
- 2021
- Full Text
- View/download PDF
81. Age-Related Heterochronicity Of Brain Morphometry May Bias Voxelwise Findings.
- Author
-
Alyssa H. Zhu, Paul M. Thompson, and Neda Jahanshad
- Published
- 2021
- Full Text
- View/download PDF
82. Predicting Progression from Mild Cognitive Impairment to Alzheimer's Disease using MRI-based Cortical Features and a Two-State Markov Model.
- Author
-
Eleonora Ficiarà, Valentino Crespi, Shruti Prashant Gadewar, Sophia I. Thomopoulos, Joshua Boyd, Paul M. Thompson, Neda Jahanshad, and Fabrizio Pizzagalli
- Published
- 2021
- Full Text
- View/download PDF
83. Region Specific Automatic Quality Assurance For MRI-Derived Cortical Segmentations.
- Author
-
Shruti Gadewar, Alyssa H. Zhu, Sophia I. Thomopoulos, Zhuocheng Li, Iyad Ba Gari, Piyush Maiti, Paul M. Thompson, and Neda Jahanshad
- Published
- 2021
- Full Text
- View/download PDF
84. Membership Inference Attacks on Deep Regression Models for Neuroimaging.
- Author
-
Umang Gupta, Dimitris Stripelis, Pradeep K. Lam, Paul M. Thompson, José Luis Ambite, and Greg Ver Steeg
- Published
- 2021
85. Deep Learning on SDF for Classifying Brain Biomarkers.
- Author
-
Zhangsihao Yang, Jianfeng Wu, Paul M. Thompson, and Yalin Wang 0001
- Published
- 2021
- Full Text
- View/download PDF
86. Disentangled and Proportional Representation Learning for Multi-view Brain Connectomes.
- Author
-
Yanfu Zhang, Liang Zhan, Shandong Wu, Paul M. Thompson, and Heng Huang
- Published
- 2021
- Full Text
- View/download PDF
87. Preliminary validation of a structural magnetic resonance imaging metric for tracking dementia-related neurodegeneration and future decline
- Author
-
Gavin T. Kress, Emily S. Popa, Paul M. Thompson, Susan Y. Bookheimer, Sophia I. Thomopoulos, Christopher R.K. Ching, Hong Zheng, Daniel A. Hirsh, David A. Merrill, Stella E. Panos, Cyrus A. Raji, Prabha Siddarth, and Jennifer E. Bramen
- Subjects
Mild cognitive impairment ,Alzheimer’s disease ,Dementia ,Magnetic resonance imaging ,Biomarker ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline and atrophy in the medial temporal lobe (MTL) and subsequent brain regions. Structural magnetic resonance imaging (sMRI) has been widely used in research and clinical care for diagnosis and monitoring AD progression. However, atrophy patterns are complex and vary by patient. To address this issue, researchers have made efforts to develop more concise metrics that can summarize AD-specific atrophy. Many of these methods can be difficult to interpret clinically, hampering adoption.In this study, we introduce a novel index which we call an “AD-NeuroScore,” that uses a modified Euclidean-inspired distance function to calculate differences between regional brain volumes associated with cognitive decline. The index is adjusted for intracranial volume (ICV), age, sex, and scanner model. We validated AD-NeuroScore using 929 older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, with a mean age of 72.7 years (SD = 6.3; 55.1–91.5) and cognitively normal (CN), mild cognitive impairment (MCI), or AD diagnoses.Our validation results showed that AD-NeuroScore was significantly associated with diagnosis and disease severity scores (measured by MMSE, CDR-SB, and ADAS-11) at baseline. Furthermore, baseline AD-NeuroScore was associated with both changes in diagnosis and disease severity scores at all time points with available data. The performance of AD-NeuroScore was equivalent or superior to adjusted hippocampal volume (AHV), a widely used metric in AD research. Further, AD-NeuroScore typically performed as well as or sometimes better when compared to other existing sMRI-based metrics.In conclusion, we have introduced a new metric, AD-NeuroScore, which shows promising results in detecting AD, benchmarking disease severity, and predicting disease progression. AD-NeuroScore differentiates itself from other metrics by being clinically practical and interpretable.
- Published
- 2023
- Full Text
- View/download PDF
88. Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations
- Author
-
Ashley D. Harris, Houshang Amiri, Mariana Bento, Ronald Cohen, Christopher R. K. Ching, Christina Cudalbu, Emily L. Dennis, Arne Doose, Stefan Ehrlich, Ivan I. Kirov, Ralf Mekle, Georg Oeltzschner, Eric Porges, Roberto Souza, Friederike I. Tam, Brian Taylor, Paul M. Thompson, Yann Quidé, Elisabeth A. Wilde, John Williamson, Alexander P. Lin, and Brenda Bartnik-Olson
- Subjects
magnetic resonance spectroscopy ,harmonization ,multi-site ,multi-vendor ,prospective ,retrospective ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Magnetic resonance spectroscopy is a powerful, non-invasive, quantitative imaging technique that allows for the measurement of brain metabolites that has demonstrated utility in diagnosing and characterizing a broad range of neurological diseases. Its impact, however, has been limited due to small sample sizes and methodological variability in addition to intrinsic limitations of the method itself such as its sensitivity to motion. The lack of standardization from a data acquisition and data processing perspective makes it difficult to pool multiple studies and/or conduct multisite studies that are necessary for supporting clinically relevant findings. Based on the experience of the ENIGMA MRS work group and a review of the literature, this manuscript provides an overview of the current state of MRS data harmonization. Key factors that need to be taken into consideration when conducting both retrospective and prospective studies are described. These include (1) MRS acquisition issues such as pulse sequence, RF and B0 calibrations, echo time, and SNR; (2) data processing issues such as pre-processing steps, modeling, and quantitation; and (3) biological factors such as voxel location, age, sex, and pathology. Various approaches to MRS data harmonization are then described including meta-analysis, mega-analysis, linear modeling, ComBat and artificial intelligence approaches. The goal is to provide both novice and experienced readers with the necessary knowledge for conducting MRS data harmonization studies.
- Published
- 2023
- Full Text
- View/download PDF
89. Association between brain similarity to severe mental illnesses and comorbid cerebral, physical, and cognitive impairments
- Author
-
Yizhou Ma, Mark D. Kvarta, Bhim M. Adhikari, Joshua Chiappelli, Xiaoming Du, Andrew van der Vaart, Eric L. Goldwaser, Heather Bruce, Kathryn S. Hatch, Si Gao, Ann Summerfelt, Neda Jahanshad, Paul M. Thompson, Thomas E. Nichols, L. Elliot Hong, and Peter Kochunov
- Subjects
Severe mental illnesses ,regional vulnerability index ,white matter hyperintensities ,cardiometabolic health ,processing speed ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Severe mental illnesses (SMIs) are often associated with compromised brain health, physical comorbidities, and cognitive deficits, but it is incompletely understood whether these comorbidities are intrinsic to SMI pathophysiology or secondary to having SMIs. We tested the hypothesis that cerebral, cardiometabolic, and cognitive impairments commonly observed in SMIs can be observed in non-psychiatric individuals with SMI-like brain patterns of deviation as seen on magnetic resonance imaging. 22,883 participants free of common neuropsychiatric conditions from the UK Biobank (age = 63.4 ± 7.5 years, range = 45–82 years, 50.9% female) were split into discovery and replication samples. The regional vulnerability index (RVI) was used to quantify each participant's respective brain similarity to meta-analytical patterns of schizophrenia spectrum disorder, bipolar disorder, and major depressive disorder in gray matter thickness, subcortical gray matter volume, and white matter integrity. Cluster analysis revealed five clusters with distinct RVI profiles. Compared with a cluster with no RVI elevation, a cluster with RVI elevation across all SMIs and brain structures showed significantly higher volume of white matter hyperintensities (Cohen's d = 0.59, pFDR < 10−16), poorer cardiovascular (Cohen's d = 0.30, pFDR < 10−16) and metabolic (Cohen's d = 0.12, pFDR = 1.3 × 10−4) health, and slower speed of information processing (|Cohen's d| = 0.11-0.17, pFDR = 1.6 × 10−3-4.6 × 10−8). This cluster also had significantly higher level of C-reactive protein and alcohol use (Cohen's d = 0.11 and 0.28, pFDR = 4.1 × 10−3 and 1.1 × 10−11). Three other clusters with respective RVI elevation in gray matter thickness, subcortical gray matter volume, and white matter integrity showed intermediate level of white matter hyperintensities, cardiometabolic health, and alcohol use. Our results suggest that cerebral, physical, and cognitive impairments in SMIs may be partly intrinsic via shared pathophysiological pathways with SMI-related brain anatomical changes.
- Published
- 2023
- Full Text
- View/download PDF
90. Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume
- Author
-
Yuanchao Zheng, Melanie E. Garrett, Delin Sun, Emily K. Clarke-Rubright, Courtney C. Haswell, Adam X. Maihofer, Jeremy A. Elman, Carol E. Franz, Michael J. Lyons, William S. Kremen, Matthew Peverill, Kelly Sambrook, Katie A. McLaughlin, Nicholas D. Davenport, Seth Disner, Scott R. Sponheim, Elpiniki Andrew, Mayuresh Korgaonkar, Richard Bryant, Tim Varkevisser, Elbert Geuze, Jonathan Coleman, Jean C. Beckham, Nathan A. Kimbrel, Danielle Sullivan, Mark Miller, Jasmeet Hayes, Mieke Verfaellie, Erika Wolf, David Salat, Jeffrey M. Spielberg, William Milberg, Regina McGlinchey, Emily L. Dennis, Paul M. Thompson, Sarah Medland, Neda Jahanshad, Caroline M. Nievergelt, Allison E. Ashley-Koch, Mark W. Logue, and Rajendra A. Morey
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract The volume of subcortical structures represents a reliable, quantitative, and objective phenotype that captures genetic effects, environmental effects such as trauma, and disease effects such as posttraumatic stress disorder (PTSD). Trauma and PTSD represent potent exposures that may interact with genetic markers to influence brain structure and function. Genetic variants, associated with subcortical volumes in two large normative discovery samples, were used to compute polygenic scores (PGS) for the volume of seven subcortical structures. These were applied to a target sample enriched for childhood trauma and PTSD. Subcortical volume PGS from the discovery sample were strongly associated in our trauma/PTSD enriched sample (n = 7580) with respective subcortical volumes of the hippocampus (p = 1.10 × 10−20), thalamus (p = 7.46 × 10−10), caudate (p = 1.97 × 10−18), putamen (p = 1.7 × 10−12), and nucleus accumbens (p = 1.99 × 10−7). We found a significant association between the hippocampal volume PGS and hippocampal volume in control subjects from our sample, but was absent in individuals with PTSD (GxE; (beta = −0.10, p = 0.027)). This significant GxE (PGS × PTSD) relationship persisted (p
- Published
- 2021
- Full Text
- View/download PDF
91. A comparison of methods to harmonize cortical thickness measurements across scanners and sites
- Author
-
Delin Sun, Gopalkumar Rakesh, Courtney C. Haswell, Mark Logue, C. Lexi Baird, Erin N. O'Leary, Andrew S. Cotton, Hong Xie, Marijo Tamburrino, Tian Chen, Emily L. Dennis, Neda Jahanshad, Lauren E. Salminen, Sophia I. Thomopoulos, Faisal Rashid, Christopher R.K. Ching, Saskia B.J. Koch, Jessie L. Frijling, Laura Nawijn, Mirjam van Zuiden, Xi Zhu, Benjamin Suarez-Jimenez, Anika Sierk, Henrik Walter, Antje Manthey, Jennifer S. Stevens, Negar Fani, Sanne J.H. van Rooij, Murray Stein, Jessica Bomyea, Inga K. Koerte, Kyle Choi, Steven J.A. van der Werff, Robert R.J.M. Vermeiren, Julia Herzog, Lauren A.M. Lebois, Justin T. Baker, Elizabeth A. Olson, Thomas Straube, Mayuresh S. Korgaonkar, Elpiniki Andrew, Ye Zhu, Gen Li, Jonathan Ipser, Anna R. Hudson, Matthew Peverill, Kelly Sambrook, Evan Gordon, Lee Baugh, Gina Forster, Raluca M. Simons, Jeffrey S. Simons, Vincent Magnotta, Adi Maron-Katz, Stefan du Plessis, Seth G. Disner, Nicholas Davenport, Daniel W. Grupe, Jack B. Nitschke, Terri A. deRoon-Cassini, Jacklynn M. Fitzgerald, John H. Krystal, Ifat Levy, Miranda Olff, Dick J. Veltman, Li Wang, Yuval Neria, Michael D. De Bellis, Tanja Jovanovic, Judith K. Daniels, Martha Shenton, Nic J.A. van de Wee, Christian Schmahl, Milissa L. Kaufman, Isabelle M. Rosso, Scott R. Sponheim, David Bernd Hofmann, Richard A. Bryant, Kelene A. Fercho, Dan J. Stein, Sven C. Mueller, Bobak Hosseini, K. Luan Phan, Katie A. McLaughlin, Richard J. Davidson, Christine L. Larson, Geoffrey May, Steven M. Nelson, Chadi G. Abdallah, Hassaan Gomaa, Amit Etkin, Soraya Seedat, Ilan Harpaz-Rotem, Israel Liberzon, Theo G.M. van Erp, Yann Quidé, Xin Wang, Paul M. Thompson, and Rajendra A. Morey
- Subjects
Data Harmonization ,Scanner Effects ,Site Effects ,Cortical Thickness ,ComBat ,ComBat-GAM ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants’ demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data: (1) linear mixed-effects model (LME) that models site-specific random intercepts (LMEINT), (2) LME that models both site-specific random intercepts and age-related random slopes (LMEINT+SLP), (3) ComBat, and (4) ComBat with a generalized additive model (ComBat-GAM). Our test case for comparing harmonization methods was cortical thickness data aggregated from 29 sites, which included 1,340 cases with posttraumatic stress disorder (PTSD) (6.2–81.8 years old) and 2,057 trauma-exposed controls without PTSD (6.3–85.2 years old). We found that, compared to the other data harmonization methods, data processed with ComBat-GAM was more sensitive to the detection of significant case-control differences (Χ2(3) = 63.704, p < 0.001) as well as case-control differences in age-related cortical thinning (Χ2(3) = 12.082, p = 0.007). Both ComBat and ComBat-GAM outperformed LME methods in detecting sex differences (Χ2(3) = 9.114, p = 0.028) in regional cortical thickness. ComBat-GAM also led to stronger estimates of age-related declines in cortical thickness (corrected p-values < 0.001), stronger estimates of case-related cortical thickness reduction (corrected p-values < 0.001), weaker estimates of age-related declines in cortical thickness in cases than controls (corrected p-values < 0.001), stronger estimates of cortical thickness reduction in females than males (corrected p-values < 0.001), and stronger estimates of cortical thickness reduction in females relative to males in cases than controls (corrected p-values < 0.001). Our results support the use of ComBat-GAM to minimize confounds and increase statistical power when harmonizing data with non-linear effects, and the use of either ComBat or ComBat-GAM for harmonizing data with linear effects.
- Published
- 2022
- Full Text
- View/download PDF
92. Cerebral blood flow and cardiovascular risk effects on resting brain regional homogeneity
- Author
-
Bhim M. Adhikari, L. Elliot Hong, Zhiwei Zhao, Danny J.J. Wang, Paul M. Thompson, Neda Jahanshad, Alyssa H. Zhu, Stefan Holiga, Jessica A. Turner, Theo G.M. van Erp, Vince D. Calhoun, Kathryn S. Hatch, Heather Bruce, Stephanie M. Hare, Joshua Chiappelli, Eric L. Goldwaser, Mark D. Kvarta, Yizhou Ma, Xiaoming Du, Thomas E. Nichols, Alan R. Shuldiner, Braxton D. Mitchell, Juergen Dukart, Shuo Chen, and Peter Kochunov
- Subjects
Arterial-spin labeling ,Correlation ,Local functional connectivity ,Multivariate mediation analysis ,Resting state functional MRI ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Regional homogeneity (ReHo) is a measure of local functional brain connectivity that has been reported to be altered in a wide range of neuropsychiatric disorders. Computed from brain resting-state functional MRI time series, ReHo is also sensitive to fluctuations in cerebral blood flow (CBF) that in turn may be influenced by cerebrovascular health. We accessed cerebrovascular health with Framingham cardiovascular risk score (FCVRS). We hypothesize that ReHo signal may be influenced by regional CBF; and that these associations can be summarized as FCVRS→CBF→ReHo. We used three independent samples to test this hypothesis. A test-retest sample of N = 30 healthy volunteers was used for test-retest evaluation of CBF effects on ReHo. Amish Connectome Project (ACP) sample (N = 204, healthy individuals) was used to evaluate association between FCVRS and ReHo and testing if the association diminishes given CBF. The UKBB sample (N = 6,285, healthy participants) was used to replicate the effects of FCVRS on ReHo. We observed strong CBF→ReHo links (p
- Published
- 2022
- Full Text
- View/download PDF
93. A Univariate Persistent Brain Network Feature Based on the Aggregated Cost of Cycles from the Nested Filtration Networks.
- Author
-
Mohammad Farazi, Liang Zhan, Natasha Leporé, Paul M. Thompson, and Yalin Wang 0001
- Published
- 2020
- Full Text
- View/download PDF
94. Multimodal Learning with Incomplete Modalities by Knowledge Distillation.
- Author
-
Qi Wang, Liang Zhan, Paul M. Thompson, and Jiayu Zhou
- Published
- 2020
- Full Text
- View/download PDF
95. A Deep Transfer Learning Framework for 3D Brain Imaging Based on Optimal Mass Transport.
- Author
-
Ling-Li Zeng, Christopher R. K. Ching, Zvart Abaryan, Sophia I. Thomopoulos, Kai Gao, Alyssa H. Zhu, Anjanibhargavi Ragothaman, Faisal Rashid, Marc Harrison, Lauren E. Salminen, Brandalyn C. Riedel, Neda Jahanshad, Dewen Hu, and Paul M. Thompson
- Published
- 2020
- Full Text
- View/download PDF
96. Deep Representation Learning for Multimodal Brain Networks.
- Author
-
Wen Zhang 0010, Liang Zhan, Paul M. Thompson, and Yalin Wang 0001
- Published
- 2020
- Full Text
- View/download PDF
97. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group
- Author
-
Anita Harrewijn, Elise M. Cardinale, Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Moji Aghajani, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteràs, Savannah Gosnell, Ramiro Salas, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, Karina S. Blair, James R. Blair, Mira Z. Hammoud, Mohammed R. Milad, Katie L. Burkhouse, K. Luan Phan, Heidi K. Schroeder, Jeffrey R. Strawn, Katja Beesdo-Baum, Neda Jahanshad, Sophia I. Thomopoulos, Randy Buckner, Jared A. Nielsen, Jordan W. Smoller, Jair C. Soares, Benson Mwangi, Mon-Ju Wu, Giovana B. Zunta-Soares, Michal Assaf, Gretchen J. Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rachel Berta, Erica Tamburo, Rebecca B. Price, Gisele G. Manfro, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostić, Ana Munjiza Jovanovic, Bianca A. V. Alberton, Brenda Benson, Gabrielle F. Freitag, Courtney A. Filippi, Andrea L. Gold, Ellen Leibenluft, Grace V. Ringlein, Kathryn E. Werwath, Hannah Zwiebel, André Zugman, Hans J. Grabe, Sandra Van der Auwera, Katharina Wittfeld, Henry Völzke, Robin Bülow, Nicholas L. Balderston, Monique Ernst, Christian Grillon, Lilianne R. Mujica-Parodi, Helena van Nieuwenhuizen, Hugo D. Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Tali M. Ball, Gregory A. Fonzo, Martin P. Paulus, Murray B. Stein, Raquel E. Gur, Ruben C. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Jennifer Harper, Michael Myers, Michael T. Perino, Chad M. Sylvester, Qiongru Yu, Ulrike Lueken, Dick J. Veltman, Paul M. Thompson, Dan J. Stein, Nic J. A. Van der Wee, Anderson M. Winkler, and Daniel S. Pine
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging data from children and adults (5–90 years) were processed using FreeSurfer. The main analysis included the regional and vertex-wise cortical thickness, cortical surface area, and subcortical volume as dependent variables, and GAD, age, age-squared, sex, and their interactions as independent variables. Nuisance variables included IQ, years of education, medication use, comorbidities, and global brain measures. The main analysis (1020 individuals with GAD and 2999 healthy controls) included random slopes per site and random intercepts per scanner. A secondary analysis (1112 individuals with GAD and 3282 healthy controls) included fixed slopes and random intercepts per scanner with the same variables. The main analysis showed no effect of GAD on brain structure, nor interactions involving GAD, age, or sex. The secondary analysis showed increased volume in the right ventral diencephalon in male individuals with GAD compared to male healthy controls, whereas female individuals with GAD did not differ from female healthy controls. This mega-analysis combining worldwide data showed that differences in brain structure related to GAD are small, possibly reflecting heterogeneity or those structural alterations are not a major component of its pathophysiology.
- Published
- 2021
- Full Text
- View/download PDF
98. Site effects how-to and when: An overview of retrospective techniques to accommodate site effects in multi-site neuroimaging analyses
- Author
-
Johanna M. M. Bayer, Paul M. Thompson, Christopher R. K. Ching, Mengting Liu, Andrew Chen, Alana C. Panzenhagen, Neda Jahanshad, Andre Marquand, Lianne Schmaal, and Philipp G. Sämann
- Subjects
MRI ,multi-site study ,ComBat ,normative modeling ,site effect ,neuroimaging ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Site differences, or systematic differences in feature distributions across multiple data-acquisition sites, are a known source of heterogeneity that may adversely affect large-scale meta- and mega-analyses of independently collected neuroimaging data. They influence nearly all multi-site imaging modalities and biomarkers, and methods to compensate for them can improve reliability and generalizability in the analysis of genetics, omics, and clinical data. The origins of statistical site effects are complex and involve both technical differences (scanner vendor, head coil, acquisition parameters, imaging processing) and differences in sample characteristics (inclusion/exclusion criteria, sample size, ancestry) between sites. In an age of expanding international consortium research, there is a growing need to disentangle technical site effects from sample characteristics of interest. Numerous statistical and machine learning methods have been developed to control for, model, or attenuate site effects – yet to date, no comprehensive review has discussed the benefits and drawbacks of each for different use cases. Here, we provide an overview of the different existing statistical and machine learning methods developed to remove unwanted site effects from independently collected neuroimaging samples. We focus on linear mixed effect models, the ComBat technique and its variants, adjustments based on image quality metrics, normative modeling, and deep learning approaches such as generative adversarial networks. For each method, we outline the statistical foundation and summarize strengths and weaknesses, including their assumptions and conditions of use. We provide information on software availability and comment on the ease of use and the applicability of these methods to different types of data. We discuss validation and comparative reports, mention caveats and provide guidance on when to use each method, depending on context and specific research questions.
- Published
- 2022
- Full Text
- View/download PDF
99. Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Brain Imaging Consortium
- Author
-
Jean‐Paul Fouche, Nynke A. Groenewold, Tatum Sevenoaks, Sarah Heany, Christine Lochner, Pino Alonso, Marcelo C. Batistuzzo, Narcis Cardoner, Christopher R. K. Ching, Stella J. deWit, Boris Gutman, Marcelo Q. Hoexter, Neda Jahanshad, Minah Kim, Jun Soo Kwon, David Mataix‐Cols, Jose M. Menchon, Euripedes C. Miguel, Takashi Nakamae, Mary L. Phillips, Jesus Pujol, Yuki Sakai, Je‐Yeon Yun, Carles Soriano‐Mas, Paul M. Thompson, Kei Yamada, Dick J. Veltman, Odile A. vanden Heuvel, and Dan J. Stein
- Subjects
anxiety ,depression ,gray matter ,magnetic resonance imaging ,neuroimaging ,obsessive‐compulsive disorder ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Objective Neuroimaging studies of obsessive‐compulsive disorder (OCD) patients have highlighted the important role of deep gray matter structures. Less work has however focused on subcortical shape in OCD patients. Methods Here we pooled brain MRI scans from 412 OCD patients and 368 controls to perform a meta‐analysis utilizing the ENIGMA‐Shape protocol. In addition, we investigated modulating effects of medication status, comorbid anxiety or depression, and disease duration on subcortical shape. Results There was no significant difference in shape thickness or surface area between OCD patients and healthy controls. For the subgroup analyses, OCD patients with comorbid depression or anxiety had lower thickness of the hippocampus and caudate nucleus and higher thickness of the putamen and pallidum compared to controls. OCD patients with comorbid depression had lower shape surface area in the thalamus, caudate nucleus, putamen, hippocampus, and nucleus accumbens and higher shape surface area in the pallidum. OCD patients with comorbid anxiety had lower shape surface area in the putamen and the left caudate nucleus and higher shape surface area in the pallidum and the right caudate nucleus. Further, OCD patients on medication had lower shape thickness of the putamen, thalamus, and hippocampus and higher thickness of the pallidum and caudate nucleus, as well as lower shape surface area in the hippocampus and amygdala and higher surface area in the putamen, pallidum, and caudate nucleus compared to controls. There were no significant differences between OCD patients without co‐morbid anxiety and/or depression and healthy controls on shape measures. In addition, there were also no significant differences between OCD patients not using medication and healthy controls. Conclusions The findings here are partly consistent with prior work on brain volumes in OCD, insofar as they emphasize that alterations in subcortical brain morphology are associated with comorbidity and medication status. Further work is needed to understand the biological processes contributing to subcortical shape.
- Published
- 2022
- Full Text
- View/download PDF
100. Microhabitat variables influencing the presence and abundance of birds in floodplain grassland of the lower Ganges and Brahmaputra rivers, Bangladesh
- Author
-
Israt Jahan, Tommaso Savini, Paul M. Thompson, Philip D. Round, and George A. Gale
- Subjects
Grassland bird community ,Habitat associations ,Vegetation structure ,Agriculture ,Ecology ,QH540-549.5 - Abstract
Grassland bird communities are likely declining in all major grassland ecosystems globally due to habitat loss and modification, yet knowledge of the status of many tropical grassland bird communities is relatively poor. This study investigated the bird community structure and its associations with vegetation characteristics and potential human impacts in seasonal floodplain grassland along the lower Ganges and Brahmaputra Rivers, Bangladesh (part of the Indo-Gangetic Plain) during 2018–2019 through point counts of birds combined with vegetation surveys. Bird responses were assessed by diversity indexes, non-metric multidimensional scaling ordination and linear models. Results show that the total resident bird community (31 grassland specialists, 34 generalists and 10 waterbirds) overlapped among the four major vegetation types in the study area (forbs and bushes, Saccharum sp., Cynodon sp. and cropland). The diversity of the total bird community increased with cover of forbs and bushes, while the overall diversity of grassland specialists (those adapted to and reliant on some variety of grassland habitat for part or all of their life cycle whether feeding or breeding.) increased with Saccharum sp. cover but decreased with increased crop cover. The diversity of the total bird community and all grassland specialist birds showed no variation with vegetation height. However, the abundance of grassland specialists showed a strong increase with increases in vegetation height. Among the grassland specialists, nine species that were entirely dependent on tall grasses for breeding were considered as obligate tall grass breeders. The abundance of these tall grass breeders decreased with greater cover of both Cynodon sp. and crops but increased with greater cover of Saccharum sp. The retention of vegetation with heights > 150 cm was therefore important to conservation and management of this community. Regular seasonal herding of cattle in these floodplain grasslands was widespread and it was therefore difficult to compare grazed with ungrazed areas. The diversity of neither the total bird community nor the overall grassland specialists showed any association with grazing intensity. However, grazing impacted negatively on the abundance of obligate tall grass breeders. Limited grass harvesting increased the overall diversity of the grassland specialist bird community. The estimated density of nine species of obligate tall grass breeders ranged from 0.19 to 4.41 birds/ha. Continuing rapid agricultural expansion was observed and is a prominent threat to these birds. More habitat-specific information and monitoring are required to quantify risks and aid conservation planning.
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.