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Background Early in the coronavirus disease 2019 (COVID-19) pandemic, peak viral loads coincided with symptom onset. We hypothesized that in a highly immune population, symptom onset might occur earlier in infection, coinciding with lower viral loads. Methods We assessed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A viral loads relative to symptom duration in symptomatic adults (≥16 years) presenting for testing in Georgia (4/2022–4/2023; Omicron variant predominant). Participants provided symptom duration and recent testing history. Nasal swabs were tested by Xpert Xpress SARS-CoV-2/Flu/RSV assay and cycle threshold (Ct) values recorded. Nucleoprotein concentrations in SARS-CoV-2 polymerase chain reaction (PCR)-positive samples were measured by single molecule array. To estimate hypothetical antigen rapid diagnostic test (Ag RDT) sensitivity on each day after symptom onset, percentages of individuals with Ct value ≤30 or ≤25 were calculated. Results Of 348 newly-diagnosed SARS-CoV-2 PCR-positive individuals (65.5% women, median 39.2 years), 317/348 (91.1%) had a history of vaccination, natural infection, or both. By both Ct value and antigen concentration measurements, median viral loads rose from the day of symptom onset and peaked on the fourth/fifth day. Ag RDT sensitivity estimates were 30.0%–60.0% on the first day, 59.2%–74.8% on the third day, and 80.0%–93.3% on the fourth day of symptoms. In 74 influenza A PCR-positive individuals (55.4% women; median 35.0 years), median influenza viral loads peaked on the second day of symptoms. Conclusions In a highly immune adult population, median SARS-CoV-2 viral loads peaked around the fourth day of symptoms. Influenza A viral loads peaked soon after symptom onset. These findings have implications for ongoing use of Ag RDTs for COVID-19 and influenza. [ABSTRACT FROM AUTHOR]

Background: Evidence suggests that adults with intellectual disability (ID) are vulnerable to poor health outcomes. This paper describes the health status and medication use of adults with ID in Western Australia. Method: We conducted a cross-sectional survey by interview of 328 adults with ID (M age = 37 years, range: 18-82) and their families/support persons (79% proxy or joint informants). Results: Although 90% of participants reported long-term health conditions (M = 2.6, range: 0-10), including epilepsy, allergies, eczema, asthma, and mental health problems, three quarters of the participants (77%) described their health as good or very good. Younger participants (18-44 years) reported osteoporosis and stroke, conditions commonly associated with ageing, more often than the general population at those ages. Medication use was high, with 70% taking one or more medications (Mdn = 3 medications, range: 0-21). Conclusions: Many participants reported that health problems affected their daily lives, yet the majority reported good health. Long-term health conditions were common and many people used several types of medications. Participants had poorer health than the Western Australian population overall. Careful monitoring of health conditions and regular review of medications are recommended to improve health outcomes for adults with ID.

A crucial step in creating cutting-edge soft magnetic alloys is the nanocrystallization of Fe-based amorphous alloys. However, it is unclear how the thermal history affects the nanocrystallization. In this work, high-precision nanocalorimetry and in-situ high-temperature transmission electron microscopy are used to systematically examine how the pre-annealing relaxation process affects the nanocrystallization of Fe-based amorphous alloys. We discover that the glass with more thermal energy storage will crystallize into superb nanocrystalline structures with exceptionally advanced soft magnetism. The soft magnetic properties of Fe-B nanocrystalline alloys can be improved by increasing the relaxation temperature. This finding provides solid and clear evidence for the influences of thermal history on crystallization behavior for Fe-based amorphous alloys, which is helpful for designing advanced soft magnetic nanocrystalline alloys. [ABSTRACT FROM AUTHOR]

A preference to novelty paradigm used to study human infants (Quinn, 2002) examined attention to novel animal pictures at subordinate, basic and superordinate levels in tamarins. First, pairs of pictures were presented in phases, starting with a monkey species (subordinate level) and ending with mammal and dinosaur sets (superordinate levels). After each phase, tests paired novel pictures from the familiarized set with a novel broader category. Look rates toward each picture were coded. Tamarins looked significantly longer at a novel species after being familiarized with a monkey species, a species-specific effect. Subjects attended equivalently to novel primate species after habituation to four monkey species, but looked significantly longer at pictures of mammals, marking a more global-level inclusion and exclusion. Superordinate testing revealed that more novel and diverse sets were differentiated attentionally. The evidence implies that natural categorical representation occurs at an attentional level in primates in ways similar to human infants, and is affected by recent exposure and category variability.