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Advanced thermochemical technologies for plastic waste valorization represent an interesting alternative to waste-to-energy options. They are particularly appealing for waste-to-hydrogen and waste-to-chemicals applications, with autothermal steam-oxygen gasification in fluidized bed reactors showing the greatest market potential. The study describes a series of experimental tests carried out on a large pilot-scale fluidized bed gasifier, using steam and O 2 -enriched air, with increasing fractions of oxygen. Different values of the main operating parameters are varied: equivalence ratio (0.22-0.25), steam-to-carbon ratio (0.7-1.13), and steam-to-oxygen ratio (up to 3.2). The fuel consists of real mixed plastic waste coming from separate collection of municipal solid wastes. The data obtained are used to investigate in depth the role of the main operating parameters and to improve and validate a recently developed one-dimensional kinetic model for waste gasification. The validation shows a good agreement between experimental data and model results, suggesting the reliability of the model to predict the reactor behavior under conditions of pure steam-oxygen gasification, relevant to many industrial applications. It has been found that the equivalence ratio is the parameter that most affects the syngas composition. At a constant equivalent ratio, the molar fraction of oxygen in the enriched air shows a limited influence on syngas composition while the steam is crucial in controlling the temperature along the reactor. Provided that the steam-to-carbon molar ratio is larger than 1.5, steam affects mainly the reactor temperature rather than the syngas composition, qualifying the steam-to-oxygen molar ratio as an instrumental parameter for smooth plant operation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Catalytic tar cracking is a promising technique for hot syngas cleaning unit in gasification plants because it can preserve tars chemical energy, so increasing the syngas heating value. The cost associated with catalyst preparation is a key issue, together with its deactivation induced by coke deposition. Iron is a cheap and frequently used catalyst, which can also be found in some industrial wastes. The study aims to assess the catalytic efficiency for tar cracking of two waste-derived materials (red mud and sewage sludge) having high content of iron. The catalysts were supported on spheres of γ-Al 2 O 3 , and their efficiency was compared to that of a pure iron catalyst. The role of support was investigated by testing pure red mud, with and without the support. A series of long-term tests using naphthalene as tar model compound were carried out under different values of process temperatures (750 °C-800 °C) and steam concentrations (0 %-7.5 %). The waste derived catalysts showed lower hydrogen yields compared to pure iron catalyst, due to their lower content of iron. On the other hand, the conversion efficiencies of all the tested catalysts resulted rather similar, since the Alkali and Alkaline-Earth Metallic species present on the surface of waste-derived catalyst help in preventing coke deposition. The iron oxidation state appears to play an important role, with reduced iron more active than its oxidised form in the tar cracking reactions. This indicates the importance of tuning steam concentration to keep constant the reduced state of iron while limiting coke deposition., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Background & Aims: Malnutrition is common in older individuals with end-stage renal disease on maintenance dialysis. Whether nutritional supplementation may improve skeletal muscle mass (SMM) and survival rate in this population is uncertain. We aimed to analyze the effect of a year of nutritional supplementation on muscle mass and survival rate in older patients on hemodiafiltration., Methods: In this observational study, older patients (≥65 years old) on maintenance hemodiafiltration were selected to receive nutritional counselling + nutritional supplementation (N = 85, Supp+) or nutritional counselling alone (N = 47, Supp-) and followed for 1 year. The outcomes were a change in SMM and sarcopenia diagnosis. The secondary outcome was 1-year mortality rate. Nutritional parameters included calf circumference, body mass index, anthropometric measurements, subjective global assessment, and handgrip strength (HGS). Data were evaluated using GLM for repeated measures with adjustment for covariates (age and diabetes)., Results: Malnutrition was found in 50.8% of patients. At baseline, patients from the Supp+ group were older and had worse nutritional parameters including hand grip strength, calf circumference, anthropometric findings and sarcopenia (all p values < 0.05). During the follow-up, there was no significant change in sarcopenia (from 50.8% to 58.3%, p = 0.108), and there was a more pronounced decrease in the SMM index in the Supp-group (p = 0.049), with a significant intervention interaction (p = 0.030). Twenty deaths occurred, 7 (35%) in the Supp- and 13 (65%) in the Supp+ group (p = 0.540). SMM index (relative risk 0.90, p = 0.030) and age (relative risk 1.07, p = 0.046) were independently associated with higher mortality rates., Conclusion: Nutritional supplementation in older and malnourished individuals undergoing hemodiafiltration mitigates the loss of the SMM index and benefits survival rate., Competing Interests: Declaration of competing interest The author declare they have no conflict of interest., (Copyright © 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)

The study focuses on mixed plastics waste (MPW), whose complex and unpredictable composition (due to high polymer heterogeneity, additives, and contaminants) makes its valorisation a true technical, environmental, economic, and regulatory challenge. Chemical recycling by means of advanced thermochemical treatments (ATT) could be a successful strategy, able to support the transition from a carbon intensive to a carbon negative sector, and alternative to the current treatments of energy recovery or mechanical downcycling. Some of these ATTs provide an efficient recovery of valuable resources, such as fuels and chemicals, but their role is mainly limited by time necessary to complete the process optimization and implement the required infrastructures. A reliable identification of the best alternatives is thus crucial. A specific LCA approach quantifies the environmental performances of a selected set of ATT technologies for resource recovery from MPW. It includes plastics-to-energy, by combustion or gasification; plastics-to-methane and plastics-to-hydrogen, by gasification; and plastics-to-oil, by thermal pyrolysis. The results highlight the crucial role of carbon capture and storage (CCS) units, which partially reduces that of the specific thermochemical treatment. The best performances, particularly for Climate Change category, are those of the MPW-to-hydrogen by gasification, followed by those of MPW-to-energy by combustion or gasification, all equipped with CCS. The sensitivity analysis considers the evolution of the European energy mix, characterised by a larger utilisation of renewable energy sources, and highlights the corresponding increased sustainability of chemical recycling by ATTs. This suggests that the MPW dilemma should be definitively solved in a close future., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Objective: To assess the bioequivalence and safety of a new formulation of mycophenolate mofetil (MMF) 500 mg (Suprimun®, Clausen, Montevideo, Uruguay) marketed in Uruguay and other South American countries, and to test Cmax/AUC as a characteristic of its absorption rate., Material and Methods: A randomized, open-label, two-way, two-treatment, two-period crossover study in 24 healthy male volunteers was carried out. One tablet (500 mg) of each formulation was administered after an overnight fast. After dosing, serial blood samples were collected for a period of 36 hours. Plasma concentrations of MPA were determined by high-performance liquid chromatography and pharmacokinetic parameters were calculated. Analysis of variance was carried out using log-transformed AUC0-36, Cmax, and Cmax/AUC0-36. 90% confidence intervals and within-subject between-subject variance were calculated. The bioequivalence of the two formulations was established at the 80% - 125% acceptance limits and untransformed tmax medians were compared using Wilcoxon test. Subjects were monitored for adverse events throughout the study., Results: The means (test and reference) were 21.14 and 20.86 µg × h × ml-1 for AUC0-36, 24.92 and 24.18 µg × h × ml-1 for AUC0-inf, 11.86 and 10.76 µg × ml-1 for Cmax and 0.51 and 0.54 h-1 for Cmax/AUC0-36. The geometric mean ratios (confidence interval 90%) of Test/Reference were 1.00 (0.95 - 1.06) for AUC0-36, 1.09 (0.96 - 1.24) for Cmax and 1.04 (0.99 - 1.09) for Cmax/ AUC0-36. The extra peaks observed are due to enterohepatic recycling of MPA. No serious or unexpected adverse events were observed during the study., Conclusions: The test formulation containing mycophenolate mofetil 500 mg met regulatory requirements for bioequivalence. Moreover, Cmax/AUC shows interesting features as a putative metric to evaluate the absorption rate of highly variable drugs like mycophenolate mofetil. Generally, both formulations were well tolerated.