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55. Long‐term efficacy and safety of brolucizumab in neovascular age‐related macular degeneration: A multicentre retrospective real‐world study.

Author

Kim, Dong Ju, Kim, Dong Geun, Kwak, Hyun Duck, Jang, Jae Yong, Ji, Yong‐Sok, Lee, Seung Hyun, Lee, Eun Kyoung, Park, Kyu Hyung, Kim, Jae Hui, Lee, Jun Sung, Song, Yumi, Kim, Seong Taeck, Shin, Min Ho, Kim, Min, Park, Sang Jun, Joo, Kwangsic, Sagong, Min, Lee, Christopher Seungkyu, and Woo, Se Joon

Subjects
MACULAR degeneration, POLYPOIDAL choroidal vasculopathy, OPTICAL coherence tomography, EYE inflammation, INDOCYANINE green, VISUAL acuity
Abstract

Purpose: To investigate the long‐term efficacy and safety of intravitreal brolucizumab (BRZ) injections in patients with typical neovascular age‐related macular degeneration (typical nAMD) and polypoidal choroidal vasculopathy (PCV). Methods: This multicentre retrospective study included 401 eyes of 398 patients with nAMD who received BRZ injection(s), with a follow‐up duration of ≥12 months. Changes in best‐corrected visual acuity (BCVA), retinal fluid evaluation and central subfield thickness (CST) on optical coherence tomography were assessed. The efficacy of BRZ was compared between typical nAMD and PCV groups. Results: Analyses were conducted with 280 eyes of 278 patients with typical nAMD and 121 eyes of 120 patients with PCV (mean age, 71.1 ± 8.6 years). 29 eyes (7.2%) were treatment naïve. The mean follow‐up period was 15.3 ± 2.8 months; the mean number of BRZ injections within 1 year was 4.5 ± 1.7. BCVA was maintained during the follow‐up period, and CST significantly improved from the first injection month and was maintained for 12 months in both the typical nAMD and PCV groups. The dry macula proportion increased from 2.7% at baseline to 56.1% at 1 month and 42.9% at 12 months. Among the 18 eyes that underwent indocyanine green angiography both before and after treatment, 10 (55.6%) showed polyp regression. Overall, the incidence of intraocular inflammation (IOI), retinal vasculitis and occlusive retinal vasculitis was 9.4% (38 eyes), 1.2% (5 eyes) and 0.5% (2 eyes), respectively. IOI occurred from the first to the sixth injections, with an average IOI onset of 28.5 ± 1.4 days. All eyes achieved IOI resolution, although the two eyes with occlusive retinal vasculitis showed a severe visual decline after IOI resolution. Conclusion: Brolucizumab was effective in maintaining BCVA and managing fluid in eyes with nAMD for up to 1 year, exhibiting a high polyp regression rate. However, the not uncommon incidence of IOI and the severe visual decline caused by the rare occlusive retinal vasculitis following BRZ treatment underscore the importance of careful monitoring and timely management. [ABSTRACT FROM AUTHOR]

Published
2024
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58. Phase Transitions and Thermoelectric Properties of Charge-Compensated Zn x Cu 12−x Sb 4 Se 13.

Author

Park, Sang Jun and Kim, Il-Ho

Subjects
*COPPER, *PHASE transitions, *ELECTRIC conductivity, *SEEBECK coefficient, *THERMAL conductivity, *COPPER-zinc alloys, *TRACE elements
Abstract

In this study, we investigated the phase transitions and thermoelectric properties of charge-compensated hakite (ZnxCu12−xSb4Se13) as a function of Zn content. Based on X-ray diffraction and a differential scanning calorimetric phase analysis, secondary phases (permingeatite and bytizite) transformed into hakite depending on the Zn content, while Zn2Cu10Sb4Se13 existed solely as hakite. Nondegenerate semiconductor behavior was observed, exhibiting increasing electrical conductivity with a rising temperature. With an increase in Zn content, the presence of mixed phases of hakite and permingeatite led to enhanced electrical conductivity. However, Zn2Cu10Sb4Se13 with a single hakite phase exhibited the lowest electrical conductivity. The Seebeck coefficient exhibited positive values, indicating that even after charge compensation (electron supply) by Zn, p-type semiconductor characteristics were maintained. With the occurrence of an intrinsic transition within the measured temperature range, the Seebeck coefficient decreased as the temperature increased; at a certain temperature, Zn2Cu10Sb4Se13 exhibited the highest value. Thermal conductivity showed a low temperature dependence, obtaining low values below 0.65 Wm−1K−1. A power factor of 0.22 mWm−1K−2 and dimensionless figure of merit of 0.31 were achieved at 623 K for ZnCu11Sb4Se13. [ABSTRACT FROM AUTHOR]

Published
2024
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59. Fine-Scale Vessel Extraction in Fundus Images by Registration with Fluorescein Angiography

Author

Noh, Kyoung Jin, Park, Sang Jun, Lee, Soochahn, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Shen, Dinggang, editor, Liu, Tianming, editor, Peters, Terry M., editor, Staib, Lawrence H., editor, Essert, Caroline, editor, Zhou, Sean, editor, Yap, Pew-Thian, editor, and Khan, Ali, editor

Published
2019
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60. Prevalence and Pattern of Geographic Atrophy in Asia: The Asian Eye Epidemiology Consortium

Author

Saenmee, Achareeya, Cao, Kai, George, Ronnie, Kazakbaeva, Gyulli M., Khalimov, Timur A., Khanna, Rohit C., Kim, Hyun Woong, Kulothungan, Vaitheeswaran, Nangia, Prabhat, Mao, Feifei, Matsuda, Fumihiko, Meng, Qianli, Namba, Hiroyuki, Pokawattana, Nattapol, Oh, Jaeryung, Park, Sang Jun, Ravindran, Ravilla, Sharma, Tarun, Shin, Jae Pil, Surya, Janani, Takahashi, Ayako, Takebayashi, Toru, Tsujikawa, Akitaka, Vashist, Praveen, Wei, Wen Bin, Yang, Xiaohui, Yu, Seung-Young, Zainullin, Rinat M., Zhao, Pei Quan, Rim, Tyler Hyungtaek, Kawasaki, Ryo, Tham, Yih-Chung, Kang, Se Woong, Ruamviboonsuk, Paisan, Bikbov, Mukharram M., Miyake, Masahiro, Hao, Jie, Fletcher, Astrid, Sasaki, Mariko, Nangia, Vinay, Sabanayagam, Charumathi, Yu, Marco, Fujiwara, Kohta, Thapa, Raba, Wong, Ian Y., Kayama, Takamasa, Chen, Shih-Jen, Kuang, Tung-Mei, Yamashita, Hidetoshi, Sundaresan, Periasamy, Chan, Jonathan C., van Rens, G.H.M.B., Sonoda, Koh-Hei, Wang, Ya Xing, Panda-Jonas, Songhomitra, Harada, Sei, Kim, Ramasamy, Ganesan, Suganeswari, Raman, Rajiv, Yamashiro, Kenji, Gilmanshin, Timur R., Jenchitr, Watanee, Park, Kyu Hyung, Gemmy Cheung, Chui Ming, Wong, Tien Yin, Wang, Ningli, Jonas, Jost B., Chakravarthy, Usha, Cheng, Ching-Yu, and Yanagi, Yasuo

Published
2020
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88. 3D Bioprinting Technologies for Tissue Engineering Applications

Author

Gu, Bon Kang, Choi, Dong Jin, Park, Sang Jun, Kim, Young-Jin, Kim, Chun-Ho, COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, Rezaei, Nima, Series Editor, Chun, Heung Jae, editor, Park, Chan Hum, editor, Kwon, Il Keun, editor, and Khang, Gilson, editor

Published
2018
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89. Chitosan for Tissue Engineering

Author

Kim, Chun-Ho, Park, Sang Jun, Yang, Dae Hyeok, Chun, Heung Jae, COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, Rezaei, Nima, Series Editor, Chun, Heung Jae, editor, Park, Kwideok, editor, Kim, Chun-Ho, editor, and Khang, Gilson, editor

Published
2018
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90. An Efficient and Comprehensive Labeling Tool for Large-Scale Annotation of Fundus Images

Author

Son, Jaemin, Kim, Sangkeun, Park, Sang Jun, Jung, Kyu-Hwan, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Stoyanov, Danail, editor, Taylor, Zeike, editor, Balocco, Simone, editor, Sznitman, Raphael, editor, Martel, Anne, editor, Maier-Hein, Lena, editor, Duong, Luc, editor, Zahnd, Guillaume, editor, Demirci, Stefanie, editor, Albarqouni, Shadi, editor, Lee, Su-Lin, editor, Moriconi, Stefano, editor, Cheplygina, Veronika, editor, Mateus, Diana, editor, Trucco, Emanuele, editor, Granger, Eric, editor, and Jannin, Pierre, editor

Published
2018
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97. Thin-film type in situ polymerized composite solid electrolyte for solid-state lithium metal batteries.

Author

Song, Young-Woong, Park, Sang-Jun, Lee, Hyochan, Kim, Min-Young, Kim, Ho-Sung, Kang, Sung-Won, Lee, Sanghyun, Kim, Yooshin, Kim, Jaekook, and Lim, Jinsub

Abstract

Solid-state batteries (SSBs) using composite solid electrolytes (CSE) have attracted attention as next-generation battery materials with high stability and energy density. In this study, we manufactured CSE using a poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) polymer host and ceramic inorganic filler. Next, a 23.3 μm electrolyte was prepared via in situ polymerization using a poly(ethylene glycol) methyl ether acrylate (PEGMEA)-based liquid precursor. The introduction of ceramic fillers and in situ polymerization can improve the mechanical strength and ionic conductivity of the electrolyte and enable a high lithium transference number owing to the anion immobilization effect. LiFePO4/Li cells using the manufactured electrolyte exhibited a high capacity maintenance rate of 93.2% over 150 cycles. In addition, a pouch cell based on the prepared electrolyte exhibited excellent stability and flexibility. [ABSTRACT FROM AUTHOR]

Published
2024
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