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The paper investigates the research output of protein folding published in the last five years, from 2018-2022. The source data are retrieved from the SCOPUS database and analyzed using MS Excel and VOS Viewer software. The VOSViewer software is mainly used for networking and visualization to understand the research pattern. A total of 12515 documents on protein folding are retrieved and considered for the study. The research finds that Uversky, V.N. was the most prolific protein folding author with the highest 42 publications and top 2560 global citations. The most productive countries in this field is the USA (4443 publications), followed by China (1791 publications), and Germany (1197 publications). The four hot keywords in protein folding research are protein binding, protein conformation, and metabolism, but protein folding is a burning author keyword. Most articles have been published by the CNRS (Centre National de la RechercheScientifique). This study will benefit future researchers worldwide in understanding the research pattern of protein folding. [ABSTRACT FROM AUTHOR]

The paper examines the global scientific literature on Molecular Docking (MD). MDis a keyapproachusedinbioinformatics to identify and developnovel compounds towards drug discovery. This study uses the bibliometric method to analyze scientific data covered in the Scopus database from 2013 to 2022 using MS Excel, R Studio, andVOS Viewer software. A total of 12173 documents on Molecular Docking were retrieved and considered for the study. The paper provides an in-depth evaluation of the research output of MD. The research found that MuthuS.was a most prolific author in MD scientific research, with 98 publications that received 1481 global citations. The most productivecountries in this field areIndia (4020 publications), followedbyChina (2675 publications), Saudi Arabia (1362 publications) and Egypt (1071 publications). The hot keywords in MD research are molecular modelling, molecular docking simulation, unclassified drug and controlled study, but Molecular Docking is the burning author keyword. The finding also shows that the publications are increasing consistently from 2013 onwards. Most articles have been published in the 'Journal of Molecular Structure'. As it is an emerging and a trending topic, it has scope for further studies. This study will benefit future researchers and practitioners worldwide in understanding the research pattern on MD and identifying the other key areas related to the topic. [ABSTRACT FROM AUTHOR]

In the development of National Aeronautics and Space Administration (NASA)'s Unmanned Aerial Vehicles (UAVs), lightweight and durable materials play a crucial role for extended high‐altitude flights. Nanoparticle‐reinforced polymer composites meet these requirements, exhibiting resistance to environmental degradation. Despite their potential, the outstanding specific strength, corrosion resistance, and dimensional stability at elevated temperatures of graphene–epoxy nanocomposites have not been fully realized due to inadequate dispersion and spatial orientation within epoxy matrices. Our recent research has introduced a mathematical framework aimed at optimizing alignment parameters for graphene nanoplatelets (GNPs) and Fe3O4‐attached GNP under a weak DC magnetic field. Subsequently, nanocomposites reinforced with GNP and aligned Fe3O4–GNP nanoparticles were fabricated using optimized parameters, and their alignment was characterized using various techniques. The current study examines the influence and comparative impact of alignment and weight percentage (wt%) loading of both nanoparticles on various mechanical properties, including tensile and compressive strength, along with failure mechanisms. It was observed that both GNP and aligned Fe3O4–GNP enhance the mechanical properties of nanocomposites, particularly notable improvements from aligned Fe3O4–GNP. The Young's modulus of GNP nanocomposites increased by 17%, while aligned Fe3O4–GNP contributed significantly to a 31% enhancement in the Young modulus. Highlights: Epoxy nanocomposites featuring well‐dispersed GNP and Fe3O4–GNP nanoparticles.Proper alignment of Fe3O4–GNP within the epoxy nanocomposite was achieved.Mechanical properties improved with GNP and aligned Fe3O4–GNP incorporation.The aligned Fe3O4–GNP exhibits advanced potential for engineering applications. [ABSTRACT FROM AUTHOR]

Background: Pyometra is the most common genital affections observed in bitches around the globe in-spite of advancement of disease diagnosis and treatment. Paucity of available literature regarding pyometra in canines in Odisha prompted to undertake an in-depth analysis on determinants linked to epidemiology, haemato-biochemical, clinicopathological and diagnostic imaging in pyometra bitches. Methods: During the period 2019-20, a total of 148 bitches were screened for canine pyometra in and around Bhubaneswar, Odisha on the basis of clinical signs, haematology and diagnostic imaging. Uterus was collected after ovario-hysterectomy and processed for histopathology through routine haematoxylin and eosin staining. Result: The overall incidence of pyometra was 15.54% with 4% mortality rate. Present study recorded a significant higher occurrence of pyometra in older bitches (>7 year, 78.26%), smaller breeds like Spitz (47.82%), nulliparous bitches (60.86%) and dogs in dioestrus stage (82.60%). Haematological examinations revealed anaemia with marked leucocytosis and neutrophilia. There was significant increase in AST, ALT, ALP and BUN concentrations in affected bitches. Enlarged uterus with hypo echoic tubular structures containing mostly echogenic fluids were constant findings through ultrasonography. Flabby uterine horns with thick and corrugated endometrial wall containing profuse mucopurulent exudates were seen during necropsy. Chronic inflammatory response leading to intense haemorrhages and hyperaemia were constant microscopic changes. The most common isolated pathogen in canine pyometra was Escherechia coli (67.5%). [ABSTRACT FROM AUTHOR]

Graphene has been hailed by scientists as the "wonder material" of the 21st century. Despite the impressive mechanical and electrical qualities of graphene in its unprocessed state, graphene‐based epoxy nanocomposites can only be used as a structural material on a small scale. The random dispersion and orientation of graphene in epoxy cause the failure. Magnetite Fe3O4 nanoparticles are synthesized and solvo‐thermally attached to the graphene nanoplatelets (GNP) surfaces in order to utilize our recently model's suggested optimized alignment parameters. Solution with properly dispersed nanoparticles, that is, Fe3O4‐GNP within epoxy, is exposed to the magnetic field (0.05 T). Morphology, microstructure, and magnetic properties of GNP, Fe3O4, and Fe3O4‐GNP nanoparticles have been characterized by X‐ray diffraction, Fourier‐transform infrared spectroscopy, Raman spectroscopy, thermogravimetric analysis, differential scanning calorimetry, atomic force microscopy, X‐ray photoelectron spectroscopy, Brunauer–Emmett–Teller, transmission electron microscopy, scanning electron microscopy, energy‐dispersive X‐ray microanalysis, and vibrating sample magnetometry. The aforementioned characterization method, optical microscopy, and studying the fracture surface morphology confirmed the alignment. The fabricated aligned Fe3O4‐GNP nanocomposite is best used as a functional material. [ABSTRACT FROM AUTHOR]

Background: Apocrine gland anal sac adenocarcinoma (AGASACA) is a highly malignant disease mostly invading regional lymph nodes at the time of disease diagnosis. Methods: Twenty- two cases of Apocrine gland anal sac adenocarcinoma (AGASACA) were treated during five years. Contrast radiography with Iohexol and Lipidol were carried out to detect primary anal sac mass and regional lymph node through indirect lymphography technique. For clinical staging, ultrasonography, fine-needle aspiration cytology, histopathology of both primary tumor mass and regional lymph node were performed. Closed anal Sacculectomy was performed as curative therapy for anal sac adenocarcinoma. Result: The median age and weight of dogs at presentation were 8.4 years and 20.9 kg, respectively. Diagnostic radiology, histopathology and biochemical assay confirm twenty-two cases of anal sac adenocarcinoma and medial iliac lymph node to be sentinel lymph node. Carcinoma was of unilateral occurrence in all the dogs. Four (18%) dogs had hypercalcemia and twelve (54%) had metastases to the regional lymph nodes with clinical signs of tenesmus or constipation, polyuria -polydipsia and anorexia. Apocrine gland Adenocarcinoma of anal sac was found to initially metastasize to the medial iliac lymph node. Survival times of dogs treated with the surgical procedure only (8 out of 22 dogs) were appreciably longer than the dogs with therapeutic only. Animals with metastasis to regional lymph nodes or lymphadenopathy had poor prognosis. [ABSTRACT FROM AUTHOR]

In this article, the effects of damage (delamination) on the structural vibration characteristics of spar wingskin joints (SWJs) made with curved laminated composites are investigated. Three dimensional finite element analysis is employed to evaluate the natural frequencies and corresponding mode shapes of the joint structure considered. Virtual elements are implemented in the delamination region to prevent inter element penetration. The effectiveness of the finite element analysis technique used is validated with available results. Additionally, the effects of various parameters such as delamination size, curvature effect (shallowness angle), laminate stacking sequence, overlap length, and material anisotropy (modular ratio) on the free vibration responses of the curved SWJ are analyzed in details. The present delamination modeling and simulated results could serve as guidelines in designing curved laminated composite joint structures with/without delaminations. [ABSTRACT FROM AUTHOR]

Magno-elastic coupling characteristics in giant magnetostrictive thin films depend on a myriad of factors, comprising variability in Young’s modulus, thermally induced pre-stresses, the direction of the applied magnetic field and the substrate to film thickness ratio, demagnetization field etc. Due to the aforementioned reasons, the giant magnetostrictive thin films usually display characteristics that may contrast with the bulk giant magnetostrictive materials. This work studies magnetostrictive film on a compliant substrate using a generalized 3-D magneto-thermoelastic nonlinear constitutive model with the elasticity theory to include such stimuli sensitive coupled magneto-thermoelastic response. The numerical simulation of the magnetostrictive film on the compliant substrate in the form of a cantilever shows good agreement with the existing experimental data. The substrate and film thickness ratio effect on the thermal strain, Young’s modulus, magnetization and magnetostriction of films was meticulously analyzed. It has been revealed that the magneto-elastic responses rely strongly on the substrate-to-film thickness ratio. Thus, it is possible to obtain the tunable properties by controlling the composite film's thickness ratio in the design state of smart devices. [ABSTRACT FROM AUTHOR]

Background: Epulides, tumors of periodontal origin, are commonly reported in dogs and infrequently in cats. But its documentation among wild animals is scarce. Retrospective study of the available literature did not find any report of epulis in sloth bears, though dental pathology is common in captive sloth bears. The present study depicts the details about an incidence of bilateral epulides in a captive sloth bear of Nandankanan Zoological Park, Bhubaneswar, India and its successful surgical management. Methods: A male sloth bear aged about 15 years, developed bilateral swellings at the upper jaw, protruding out of the oral cavity, impeding with its normal feeding and drinking. Close physical examination under general anaesthesia revealed that the swellings are bilateral epulides at the upper jaw involving canines of both sides. The epulides were surgically excised, histopathology of the excised mass was conducted and a course of antibiotic treatment was followed. Result: The epulides were found to be of fibromatous and ossifying type. In the present case, there was no recurrence of epulides at the surgical site after their excision and the procedure proved curative. This work is a complementary contribution to the dental pathology study of sloth bears in captivity. [ABSTRACT FROM AUTHOR]