Search

Your search keyword '"Pajewski, Nicholas M."' showing total 608 results
Start Over Author "Pajewski, Nicholas M."
608 results on '"Pajewski, Nicholas M."'

51. Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control

Author

Jaeger, Byron C., primary, Bress, Adam P., additional, Bundy, Joshua D., additional, Cheung, Alfred K., additional, Cushman, William C., additional, Drawz, Paul E., additional, Johnson, Karen C., additional, Lewis, Cora E., additional, Oparil, Suzanne, additional, Rocco, Michael V., additional, Rapp, Stephen R., additional, Supiano, Mark A., additional, Whelton, Paul K., additional, Williamson, Jeff D., additional, Wright, Jackson T., additional, Reboussin, David M., additional, and Pajewski, Nicholas M., additional

Published
2022
Full Text
View/download PDF

52. Development of an Advance Care Planning Portal-Based Tool for Community-Dwelling Persons Living With Cognitive Impairment: The ACPVoice Tool

Author

Gabbard, Jennifer, primary, Strahley, Ashley E., additional, Pajewski, Nicholas M., additional, Callahan, Kathryn E., additional, Foley, Kristie L., additional, Brown, Andrew, additional, Moses, Adam, additional, Kirkendall, Eric, additional, Williamson, Jeff D., additional, Brooten, Justin, additional, Marterre, Buddy, additional, and Sutfin, Erin L., additional

Published
2022
Full Text
View/download PDF

56. Development of an Advance Care Planning Portal-Based Tool for Community-Dwelling Persons Living With Cognitive Impairment: The ACPVoice Tool.

Author

Gabbard, Jennifer, Strahley, Ashley E., Pajewski, Nicholas M., Callahan, Kathryn E., Foley, Kristie L., Brown, Andrew, Moses, Adam, Kirkendall, Eric, Williamson, Jeff D., Brooten, Justin, Marterre, Buddy, and Sutfin, Erin L.

Abstract

Background: Patient portals can be an innovative and efficient way to engage patients in advance care planning (ACP). However, comprehension and judgment in older adults with cognitive impairment presents several barriers and challenges to engaging in new technology. Our objective was to develop an ACP portal-based tool (ACPVoice) for community-dwelling persons living with cognitive impairment (PLCI) by engaging end-users in the design process. Methods: Two rounds of cognitive interviews were conducted to identify and resolve cognitive issues related to comprehension, judgment, response, and to assess content validity. Purposive sampling was used with the goal of enrolling 15 different participants (five with mild cognitive impairment and five dyads (those with mild dementia and their care partner) in each round to assess respondents' understanding of questions related to advance care planning to be administered via the patient portal. Results: Twenty PLCI (mean age 78.4, 10 females [50%]) and ten care partners (mean age 60.9, 9 females [90%]) completed cognitive interviews between May 2021 and October 2021. The mean Mini-Mental State Examination score for PLCI was 25.6 (SD 2.6). Unclear wording and undefined vague and/or unfamiliar terms were the major issues identified. Revisions to item wording, response options, and instructions were made to improve question comprehension and response as well as navigational ease. Conclusion: Minor changes to the wording, format, and response options substantially improved respondents' ability to interpret the item content of the ACPVoice tool. Dissemination and implementation of the ACPVoice tool could help to engage community-dwelling PLCI in ACP discussions. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

57. Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale.

Author

Joseph, Jacob, Pajewski, Nicholas M., Dolor, Rowena J., Sellers, Mary Ann, Perdue, Letitia H., Peeples, Sheronda R., Henrie, Adam M., Woolard, Nancy, Jones, W. Schuyler, Benziger, Catherine P., Orkaby, Ariela R., Mixon, Amanda S., VanWormer, Jeffrey J., Shapiro, Michael D., Kistler, Christine E., Polonsky, Tamar S., Chatterjee, Ranee, Chamberlain, Alanna M., Forman, Daniel E., and Knowlton, Kirk U.

Subjects
*DEMENTIA prevention, *ANTILIPEMIC agents, *ACTIVE aging, *ATORVASTATIN, *COGNITION, *PREVENTIVE health services, *TREATMENT effectiveness, *DEMENTIA patients, *RANDOMIZED controlled trials, *COMPARATIVE studies, *PLACEBOS, *INDEPENDENT living, *DEMENTIA, *RESEARCH funding, *DESCRIPTIVE statistics, *STATISTICAL sampling, *PATIENT safety, *OLD age
Abstract

Whether initiation of statins could increase survival free of dementia and disability in adults aged ≥75 years is unknown. PREVENTABLE, a double‐blind, placebo‐controlled randomized pragmatic clinical trial, will compare high‐intensity statin therapy (atorvastatin 40 mg) with placebo in 20,000 community‐dwelling adults aged ≥75 years without cardiovascular disease, disability, or dementia at baseline. Exclusion criteria include statin use in the prior year or for >5 years and inability to take a statin. Potential participants are identified using computable phenotypes derived from the electronic health record and local referrals from the community. Participants will undergo baseline cognitive testing, with physical testing and a blinded lipid panel if feasible. Cognitive testing and disability screening will be conducted annually. Multiple data sources will be queried for cardiovascular events, dementia, and disability; survival is site‐reported and supplemented by a National Death Index search. The primary outcome is survival free of new dementia or persisting disability. Co‐secondary outcomes are a composite of cardiovascular death, hospitalization for unstable angina or myocardial infarction, heart failure, stroke, or coronary revascularization; and a composite of mild cognitive impairment or dementia. Ancillary studies will offer mechanistic insights into the effects of statins on key outcomes. Biorepository samples are obtained and stored for future study. These results will inform the benefit of statins for increasing survival free of dementia and disability among older adults. This is a pioneering pragmatic study testing important questions with low participant burden to align with the needs of the growing population of older adults. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

58. Automated Electronic Frailty Index is Associated with Non-home Discharge in Patients Undergoing Open Revascularization for Peripheral Vascular Disease

Author

Stutsrim, Ashlee E., Brastauskas, Ian M., Craven, Tim E., Callahan, Kathryn E., Pajewski, Nicholas M., Davis, Ross P., Corriere, Matthew A., Edwards, Matthew S., and Goldman, Matthew P.

Abstract

Background Frailty is associated with adverse surgical outcomes including post-operative complications, needs for post-acute care, and mortality. While multiple frailty screening tools exist, most are time and resource intensive. Here we examine the association of an automated electronic frailty index (eFI), derived from routine data in the Electronic Health Record (EHR), with outcomes in vascular surgery patients undergoing open, lower extremity revascularization.Methods A retrospective analysis at a single academic medical center from 2015 to 2019 was completed. Information extracted from the EHR included demographics, eFI, comorbidity, and procedure type. Frailty status was defined as fit (eFI≤0.10), pre-frail (0.100.21). Outcomes included length of stay (LOS), 30-day readmission, and non-home discharge.Results We included 295 patients (mean age 65.9 years; 31% female), with the majority classified as pre-frail (57%) or frail (32%). Frail patients exhibited a higher degree of comorbidity and were more likely to be classified as American Society of Anesthesiologist class IV (frail: 46%, pre-frail: 27%, and fit: 18%, P = 0.0012). There were no statistically significant differences in procedure type, LOS, or 30-day readmissions based on eFI. Frail patients were more likely to expire in the hospital or be discharged to an acute care facility (31%) compared to pre-frail (14%) and fit patients (15%, P = 0.002). Adjusting for comorbidity, risk of non-home discharge was higher comparing frail to pre-frail patients (OR 3.01, 95% CI 1.40-6.48).Discussion Frail patients, based on eFI, undergoing elective, open, lower extremity revascularization were twice as likely to not be discharged home.

Published
2023
Full Text
View/download PDF

61. Effect of Intensive versus Standard BP Control on AKI and Subsequent Cardiovascular Outcomes and Mortality: Findings from the SPRINT EHR Study

Author

Drawz, Paul E., primary, Rai, Nayanjot Kaur, additional, Lenoir, Kristin Macfarlane, additional, Suarez, Maritza, additional, Powell, James R., additional, Raj, Dominic S., additional, Beddhu, Srinivasan, additional, Agarwal, Anil K., additional, Soman, Sandeep, additional, Whelton, Paul K., additional, Lash, James, additional, Rahbari-Oskoui, Frederic F., additional, Dobre, Mirela, additional, Parkulo, Mark A., additional, Rocco, Michael V., additional, McWilliams, Andrew, additional, Dwyer, Jamie P., additional, Thomas, George, additional, Rahman, Mahboob, additional, Oparil, Suzanne, additional, Horwitz, Edward, additional, Pajewski, Nicholas M., additional, and Ishani, Areef, additional

Published
2022
Full Text
View/download PDF

66. Effect of Intensive Versus Standard Clinic-Based Hypertension Management on Ambulatory Blood Pressure: Results From the SPRINT (Systolic Blood Pressure Intervention Trial) Ambulatory Blood Pressure Study

Author

Drawz, Paul E., Pajewski, Nicholas M., Bates, Jeffrey T., Bello, Natalie A., Cushman, William C., Dwyer, Jamie P., Fine, Lawrence J., Goff, David C., Jr, Haley, William E., Krousel-Wood, Marie, McWilliams, Andrew, Rifkin, Dena E., Slinin, Yelena, Taylor, Addison, Townsend, Raymond, Wall, Barry, Wright, Jackson T., and Rahman, Mahboob

Published
2017
Full Text
View/download PDF

67. Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure

Author

Kurella Tamura, Manjula, primary, Gaussoin, Sarah, additional, Pajewski, Nicholas M., additional, Zaharchuk, Greg, additional, Freedman, Barry I., additional, Rapp, Stephen R., additional, Auchus, Alexander P., additional, Haley, William E., additional, Oparil, Suzanne, additional, Kendrick, Jessica, additional, Roumie, Christianne L., additional, Beddhu, Srinivasan, additional, Cheung, Alfred K., additional, Williamson, Jeff D., additional, Detre, John A., additional, Dolui, Sudipto, additional, Bryan, R. Nick, additional, Nasrallah, Ilya M., additional, Whelton, Paul, additional, Johnson, Karen C., additional, Snyder, Joni, additional, Bild, Diane, additional, Bonds, Denise, additional, Cook, Nakela, additional, Cutler, Jeffrey, additional, Fine, Lawrence, additional, Kaufmann, Peter, additional, Kimmel, Paul, additional, Launer, Lenore, additional, Moy, Claudia, additional, Riley, William, additional, Ryan, Laurie, additional, Tolunay, Eser, additional, Yang, Song, additional, Reboussin, David, additional, Williamson, Jeff, additional, Ambrosius, Walter T., additional, Applegate, William, additional, Evans, Greg, additional, Foy, Capri, additional, Kitzman, Dalane, additional, Lyles, Mary, additional, Pajewski, Nick, additional, Rapp, Steve, additional, Rushing, Scott, additional, Shah, Neel, additional, Sink, Kaycee M., additional, Vitolins, Mara, additional, Wagenknecht, Lynne, additional, Wilson, Valerie, additional, Perdue, Letitia, additional, Woolard, Nancy, additional, Craven, Tim, additional, Garcia, Katelyn, additional, Lovato, Laura, additional, Newman, Jill, additional, Lovato, James, additional, Lu, Lingyi, additional, McLouth, Chris, additional, Russell, Greg, additional, Amoroso, Bobby, additional, Davis, Patty, additional, Griffin, Jason, additional, Harris, Darrin, additional, King, Mark, additional, Lane, Kathy, additional, Roberson, Wes, additional, Steinberg, Debbie, additional, Ashford, Donna, additional, Babcock, Phyllis, additional, Chamberlain, Dana, additional, Christensen, Vickie, additional, Cloud, Loretta, additional, Collins, Christy, additional, Cook, Delilah, additional, Currie, Katherine, additional, Felton, Debbie, additional, Harpe, Stacy, additional, Howard, Marjorie, additional, Lewis, Michelle, additional, Nance, Pamela, additional, Puccinelli-Ortega, Nicole, additional, Russell, Laurie, additional, Walker, Jennifer, additional, Craven, Brenda, additional, Goode, Candace, additional, Troxler, Margie, additional, Davis, Janet, additional, Hutchens, Sarah, additional, Killeen, Anthony A., additional, Lukkari, Anna M., additional, Ringer, Robert, additional, Dillard, Brandi, additional, Archibeque, Norbert, additional, Warren, Stuart, additional, Sather, Mike, additional, Pontzer, James, additional, Taylor, Zach, additional, Soliman, Elsayed Z., additional, Zhang, Zhu-Ming, additional, Li, Yabing, additional, Campbell, Chuck, additional, Hensley, Susan, additional, Hu, Julie, additional, Keasler, Lisa, additional, Barr, Mary, additional, Taylor, Tonya, additional, Davatzikos, Christos, additional, Nasarallah, Ilya, additional, Desiderio, Lisa, additional, Elliott, Mark, additional, Borthakur, Ari, additional, Battapady, Harsha, additional, Erus, Guray, additional, Smith, Alex, additional, Wang, Ze, additional, Doshi, Jimit, additional, Wright, Jackson T., additional, Rahman, Mahboob, additional, Lerner, Alan J., additional, Still, Carolyn, additional, Wiggers, Alan, additional, Zamanian, Sara, additional, Bee, Alberta, additional, Dancie, Renee, additional, Thomas, George, additional, Schreiber, Martin, additional, Navaneethan, Sankar Dass, additional, Hickner, John, additional, Lioudis, Michael, additional, Lard, Michelle, additional, Marczewski, Susan, additional, Maraschky, Jennifer, additional, Colman, Martha, additional, Aaby, Andrea, additional, Payne, Stacey, additional, Ramos, Melanie, additional, Horner, Carol, additional, Drawz, Paul, additional, Raghavendra, Pratibha P., additional, Ober, Scott, additional, Mourad, Ronda, additional, Pallaki, Muralidhar, additional, Russo, Peter, additional, Raghavendra, Pratibha, additional, Fantauzzo, Pual, additional, Tucker, Lisa, additional, Schwing, Bill, additional, Sedor, John R., additional, Horwitz, Edward J., additional, Schellling, Jeffrey R., additional, O’Toole, John F., additional, Humbert, Lisa, additional, Tutolo, Wendy, additional, White, Suzanne, additional, Gay, Alishea, additional, Clark, Walter, additional, Hughes, Robin, additional, Dobre, Mirela, additional, Still, Carolyn H., additional, Williams, Monique, additional, Bhatt, Udayan, additional, Hebert, Lee, additional, Agarwal, Anil, additional, Murphy, Melissa Brown, additional, Ford, Nicole, additional, Stratton, Cynthia, additional, Baxter, Jody, additional, Lykins, Alicia A., additional, McKinley Neal Leena Hirmath, Alison, additional, Kwame, Osei, additional, Soe, Kyaw, additional, Miser, William F., additional, Sagrilla, Colleen, additional, Johnston, Jan, additional, Anaya, Amber, additional, Mintos, Ashley, additional, Howell, Angel A., additional, Rogers, Kelly, additional, Taylor, Sara, additional, Ebersbacher, Donald, additional, Long, Lucy, additional, Bednarchik, Beth, additional, Schnall, Adrian, additional, Smith, Jonathan, additional, Peysha, Lori, additional, Leach, Lisa, additional, Tribout, Megan, additional, Harwell, Carla, additional, Ellington, Pinkie, additional, Banerji, Mary Ann, additional, Ghody, Pranav, additional, Rambaud, Melissa Vahídeh, additional, Townsend, Raymond, additional, Cohen, Debbie, additional, Huan, Yonghong, additional, Duckworth, Mark, additional, Ford, Virginia, additional, Leshner, Juliet, additional, Davison, Ann, additional, Veen, Sarah Vander, additional, Gadegbeku, Crystal A., additional, Gillespie, Avi, additional, Paranjape, Anuradha, additional, Amoroso, Sandra, additional, Pfeffer, Zoe, additional, Quinn, Sally B., additional, He, Jiang, additional, Chen, Jing, additional, Lustigova, Eva, additional, Malone, Erin, additional, Krousel-Wood, Marie, additional, Deichmann, Richard, additional, Ronney, Patricia, additional, Muery, Susan, additional, Trapani, Donnalee, additional, Rocco, Michael, additional, Goff, David, additional, Rodriguez, Carlos, additional, Coker, Laura, additional, Hawfield, Amret, additional, Yeboah, Joseph, additional, Crago, Lenore, additional, Summerson, John, additional, Hege, Anita, additional, Diamond, Matt, additional, Mulloy, Laura, additional, Hodges, Marcela, additional, Collins, Michelle, additional, Weathers, Charlene, additional, Anderson, Heather, additional, Stone, Emily, additional, Walker, Walida, additional, McWilliams, Andrew, additional, Dulin, Michael, additional, Kuhn, Lindsay, additional, Standridge, Susan, additional, Lowe, Lindsay, additional, Everett, Kelly, additional, Preston, Kelry, additional, Norton, Susan, additional, Gaines, Silena, additional, Rizvi, Ali A., additional, Sides, Andrew W., additional, Herbert, Diamond, additional, Hix, Matthew M., additional, Whitmire, Melanie, additional, Arnold, Brittany, additional, Hutchinson, Philip, additional, Espiritu, Joseph, additional, Feinglos, Mark, additional, Kovalik, Eugene, additional, Gedon-Lipscomb, Georgianne, additional, Evans, Kathryn, additional, Thacker, Connie, additional, Zimmer, Ronna, additional, Furst, Mary, additional, Mason, MaryAnn, additional, Powell, James, additional, Bolin, Paul, additional, Zhang, Junhong, additional, Pinion, Mary, additional, Davis, Gail, additional, Bryant, Winifred, additional, Phelps, Presley, additional, Garris-Sutton, Connie, additional, Atkinson, Beatrice, additional, Contreras, Gabriele, additional, Suarez, Maritza, additional, Schulman, Ivonne, additional, Koggan, Don, additional, Vassallo, Jackie, additional, Peruyera, Gloria, additional, Whittington, Sheri, additional, Bethea, Cassandra, additional, Gilliam, Laura, additional, Pedley, Carolyn, additional, Zurek, Geraldine, additional, Baird, Miriam, additional, Herring, Charles, additional, Smoak, Mary Martha, additional, Williams, Julie, additional, Rogers, Samantha, additional, Gordon, Lindsay, additional, Kennedy, Erin, additional, Belle, Beverly, additional, McCorkle-Doomy, Jessica, additional, Adams, Jonathan, additional, Lopez, Ramon, additional, Janavs, Juris, additional, Rahbari-Oskoui, Frederic, additional, Chapman, Arlene, additional, Dollar, Allen, additional, Williams, Olubunmi, additional, Han, Yoosun, additional, Haley, William, additional, Fitzpatrick, Peter, additional, Blackshear, Joseph, additional, Shapiro, Brian, additional, Harrell, Anna, additional, Palaj, Arta, additional, Henderson, Katelyn, additional, Johnson, Ashley, additional, Gonzalez, Heath, additional, Robinson, Jermaine, additional, Tamariz, Leonardo, additional, Denizard, Jennifer, additional, Barakat, Rody, additional, Krishnamoorthy, Dhurga, additional, Greenway, Frank, additional, Monce, Ron, additional, Church, Timothy, additional, Hendrick, Chelsea, additional, Yoches, Aimee, additional, Sones, Leighanne, additional, Baltazar, Markee, additional, Pemu, Priscilla, additional, Jones, Connie, additional, Akpalu, Derrick, additional, Chelune, Gordon, additional, Childs, Jeffrey, additional, Gren, Lisa, additional, Randall, Anne, additional, Dember, Laura, additional, Soares, Denise, additional, Yee, Jerry, additional, Umanath, Kausik, additional, Ogletree, Naima, additional, Thaxton, Schawana, additional, Campana, Karen, additional, Sheldon, Dayna, additional, MacArthur, Krista, additional, Muhlestein, J. Brent, additional, Allred, Nathan, additional, Clements, Brian, additional, Dhar, Ritesh, additional, Meredith, Kent, additional, Le, Viet, additional, Miner, Edward, additional, Orford, James, additional, Riessen, Erik R., additional, Ballantyne, Becca, additional, Chisum, Ben, additional, Johnson, Kevin, additional, Peeler, Dixie, additional, Chertow, Glenn, additional, Tamura, Manju, additional, Chang, Tara, additional, Erickson, Kevin, additional, Shen, Jenny, additional, Stafford, Randall S., additional, Zaharchuk, Gregory, additional, Del Cid, Margareth, additional, Dentinger, Michelle, additional, Sabino, Jennifer, additional, Sahay, Rukmani, additional, Telminova, Ekaterina, additional, Weiner, Daniel E., additional, Sarnak, Mark, additional, Chan, Lily, additional, Civiletto, Amanda, additional, Heath, Alyson, additional, Kantor, Amy, additional, Jain, Priyanka, additional, Kirkpatrick, Bethany, additional, Well, Andrew, additional, Yuen, Barry, additional, Chonchol, Michel, additional, Farmer, Beverly, additional, Farmer, Heather, additional, Greenwald, Carol, additional, Malaczewski, Mikaela, additional, Lash, James, additional, Porter, Anna, additional, Ricardo, Ana, additional, Rosman, Robert T., additional, Cohan, Janet, additional, Barrera, Nieves Lopez, additional, Meslar, Daniel, additional, Meslar, Patricia, additional, Conroy, Margaret, additional, Unruh, Mark, additional, Hess, Rachel, additional, Jhamb, Manisha, additional, Thomas, Holly, additional, Fazio, Pam, additional, Klixbull, Elle, additional, Komlos-Weimer, Melissa, additional, Mandich, LeeAnne, additional, Vita, Tina, additional, Toto, Robert, additional, Van Buren, Peter, additional, Inrig, Julia, additional, Cruz, Martha, additional, Lightfoot, Tammy, additional, Wang, Nancy, additional, Webster, Lori, additional, Raphael, Kalani, additional, Stults, Barry, additional, Zaman, Tahir, additional, Simmons, Debra, additional, Lavasani, Tooran, additional, Filipowicz, Rebecca, additional, Wei, Guo, additional, Miller, Gracie Mary, additional, Harerra, Jenice, additional, Christensen, Jeff, additional, Giri, Ajay, additional, Chen, Xiaorui, additional, Anderton, Natalie, additional, Jensen, Arianna, additional, Lewis, Julia, additional, Burgner, Anna, additional, Dwyer, Jamie P., additional, Schulman, Gerald, additional, Herrud, Terri, additional, Leavell, Ewanda, additional, McCray, Tiffany, additional, McNeil-Simaan, Edwina, additional, Poudel, Munmun, additional, Reed, Malia, additional, Sika, Mohammed, additional, Woods, Delia, additional, Zirkenbach, Janice L., additional, Raj, Dominic S., additional, Cohen, Scott, additional, Patel, Samir, additional, Velasquez, Manuel, additional, Bastian, Roshni S., additional, Wing, Maria, additional, Roy-Chaudhury, Akshay, additional, Depner, Thomas, additional, Dalyrymple, Lorien, additional, Kaysen, George, additional, Anderson, Susan, additional, Nord, John, additional, Ix, Joachim H., additional, Goldenstein, Leonard, additional, Miracle, Cynthia M., additional, Forbang, Nketi, additional, Mircic, Maja, additional, Thomas, Brenda, additional, Tran, Tiffany, additional, Rastogi, Anjay, additional, Kim, Mihae, additional, Rashid, Mohamad, additional, Lizarraga, Bianca, additional, Hocza, Amy, additional, Sarmosyan, Kristine, additional, Norris, Jason, additional, Sharma, Tushar, additional, Chioy, Amanda, additional, Bernard, Eric, additional, Cabrera, Eleanore, additional, Lopez, Christina, additional, Nunez, Susana, additional, Riad, Joseph, additional, Schweitzer, Suzanne, additional, Sirop, Siran, additional, Thomas, Sarah, additional, Wada, Lauren, additional, Kramer, Holly, additional, Bansal, Vinod, additional, Taylor, Corliss E., additional, Segal, Mark S., additional, Hall, Karen L., additional, Kazory, Amir, additional, Gilbert, Lesa, additional, Owens, Linda, additional, Poulton, Danielle, additional, Whidden, Elaine, additional, Wiggins, Jocelyn, additional, Blaum, Caroline, additional, Nyquist, Linda, additional, Min, Lillian, additional, Gure, Tanya, additional, Lewis, Ruth, additional, Mawby, Jennifer, additional, Robinson, Eileen, additional, Lewis, Cora E., additional, Bradley, Virginia, additional, Calhoun, David, additional, Glasser, Stephen, additional, Jenkins, Kim, additional, Ramsey, Tom, additional, Qureshi, Nauman, additional, Ferguson, Karen, additional, Haider, Sumrah, additional, James, Mandy, additional, Jones, Christy, additional, Renfroe, Kim, additional, Seay, April, additional, Weigart, Carrie, additional, Thornley-Brown, Denyse, additional, Rizik, Dana, additional, Cotton, Bari, additional, Fitz-Gerald, Meredith, additional, Grimes, Tiffany, additional, Johnson, Carolyn, additional, Kennedy, Sara, additional, Mason, Chanel, additional, Rosato-Burson, Lesa, additional, Willingham, Robin, additional, Judd, Eric, additional, Breaux-Shropshire, Tonya, additional, Cook, Felice, additional, Medina, Julia, additional, Ghazi, Lama, additional, Bhatt, Hemal, additional, Lewis, James, additional, Brantley, Roman, additional, Brouilette, John, additional, Glaze, Jeffrey, additional, Hall, Stephanie, additional, Hiott, Nancy, additional, Tharpe, David, additional, Boddy, Spencer, additional, Mack, Catherine, additional, Womack, Catherine, additional, Asao, Keiko, additional, Griffin, Beate, additional, Hendrix, Carol, additional, Johnson, Karen, additional, Jones, Lisa, additional, Towers, Chelsea, additional, Punzi, Henry, additional, Cassidy, Kathy, additional, Schumacher, Kristin, additional, Irizarry, Carmen, additional, Colon, Ilma, additional, Colon-Ortiz, Pedro, additional, Colón-Hernández, Pedro J., additional, Carrasquillo-Navarro, Orlando J., additional, Carrasquillo, Merari, additional, Vazquez, Nivea, additional, Sosa-Padilla, Miguel, additional, Cintron-Pinero, Alex, additional, Ayala, Mayra, additional, Pacheco, Olga, additional, Rivera, Catalina, additional, Sotomayor-Gonzalez, Irma, additional, Claudio, Jamie, additional, Lazaro, Jose, additional, Arce, Migdalia, additional, Heres, Lourdes, additional, Perez, Alba, additional, Tavarez-Valle, Jose, additional, Arocho, Ferlinda, additional, Torres, Mercedes, additional, Vazquez, Melvaliz, additional, Aurigemma, Gerard P., additional, Takis-Smith, Rebecca, additional, Andrieni, Julia, additional, Bodkin, Noelle, additional, Chaudhary, Kiran, additional, Hu, Paula, additional, Kostis, John, additional, Cosgrove, Nora, additional, Bankowski, Denise, additional, Boleyn, Monica, additional, Casazza, Laurie, additional, Giresi, Victoria, additional, Patel, Tosha, additional, Squindo, Erin, additional, Wu, Yan, additional, Henson, Zeb, additional, Wofford, Marion, additional, Lowery, Jessica, additional, Minor, Deborah, additional, Harkins, Kimberley, additional, Auchus, Alexander, additional, Flessner, Michael, additional, Adair, Cathy, additional, Asher, Jordan, additional, Loope, Debbie, additional, Cobb, Rita, additional, Venegas, Reiner, additional, Bigger, Thomas, additional, Bello, Natalie, additional, Homma, Shunichi, additional, Donovan, Daniel, additional, Lopez-Jimenez, Carlos, additional, Tirado, Amilcar, additional, Getaneh, Asqual, additional, Tang, Rocky, additional, Durant, Sabrina, additional, Maurer, Mathew, additional, Teruya, Sergio, additional, Helmke, Stephen, additional, Alvarez, Julissa, additional, Campbell, Ruth, additional, Pisoni, Roberto, additional, Sturdivant, Rachel, additional, Brooks, Deborah, additional, Counts, Caroline, additional, Hunt, Vickie, additional, Spillers, Lori, additional, Brautigam, Donald, additional, Kitchen, Timothy, additional, Gorman, Timothy, additional, Sayers, Jessica, additional, Button, Sarah, additional, Chiarot, June, additional, Fischer, Rosemary, additional, Lyon, Melissa, additional, Resnick, Maria, additional, Hodges, Nicole, additional, Ferreira, Jennifer, additional, Cushman, William, additional, Wall, Barry, additional, Nichols, Linda, additional, Burns, Robert, additional, Martindale-Adams, Jennifer, additional, Berlowitz, Dan, additional, Clark, Elizabeth, additional, Walsh, Sandy, additional, Geraci, Terry, additional, Huff, Carol, additional, Shaw, Linda, additional, Servilla, Karen, additional, Vigil, Darlene, additional, Barrett, Terry, additional, Sweeney, Mary Ellen, additional, Johnson, Rebecca, additional, McConnell, Susan, additional, Salles, Khadijeh Shahid, additional, Watson, Francoise, additional, Schenk, Cheryl, additional, Whittington, Laura, additional, Maher, Maxine, additional, Williams, Jonathan, additional, Swartz, Stephen, additional, Conlin, Paul, additional, Alexis, George, additional, Lamkin, Rebecca, additional, Underwood, Patti, additional, Gomes, Helen, additional, Rosendorff, Clive, additional, Atlas, Stephen, additional, Khan, Saadat, additional, Gonzalez, Waddy, additional, Barcham, Samih, additional, Kwon, Lawrence, additional, Matar, Matar, additional, Adhami, Anwar, additional, Basile, Jan, additional, John, Joseph, additional, Ham, Deborah, additional, Baig, Hadi, additional, Saklayen, Mohammed, additional, Yap, Jason, additional, Neff, Helen, additional, Miller, Carol, additional, Zheng-Phelan, Ling, additional, Gappy, Saib, additional, Rau, Shiva, additional, Raman, Arathi, additional, Berchou, Vicki, additional, Jones, Elizabeth, additional, Olgren, Erin, additional, Marbury, Cynthia, additional, Yudd, Michael, additional, Sastrasinh, Sithiporn, additional, Michaud, Jennine, additional, Fiore, Jessica, additional, Kutza, Marianne, additional, Shorr, Ronald, additional, Mount, Rattana, additional, Dunn, Helen, additional, Stinson, Susan, additional, Hunter, Jessica, additional, Taylor, Addison, additional, Bates, Jeffery, additional, Anderson, Catherine, additional, Kirchner, Kent, additional, Stubbs, Jodi, additional, Hinton, Ardell, additional, Spencer, Anita, additional, Sharma, Santosh, additional, Wiegmann, Thomas, additional, Mehta, Smita, additional, Krause, Michelle, additional, Dishongh, Kate, additional, Childress, Richard, additional, Gyamlani, Geeta, additional, Niakan, Atossa, additional, Thompson, Cathy, additional, Moody, Janelle, additional, Gresham, Carolyn, additional, Whittle, Jeffrey, additional, Barnas, Gary, additional, Wolfgram, Dawn, additional, Cortese, Heidi, additional, Johnson, Jonette, additional, Roumie, Christianne, additional, Hung, Adriana, additional, Wharton, Jennifer, additional, Niesner, Kurt, additional, Katz, Lois, additional, Richardson, Elizabeth, additional, Brock, George, additional, Holland, Joanne, additional, Dixon, Troy, additional, Zias, Athena, additional, Spiller, Christine, additional, Baker, Penelope, additional, Felicetta, James, additional, Rehman, Shakaib, additional, Bingham, Kelli, additional, Watnick, Suzanne, additional, Cohen, David, additional, Weiss, Jessica, additional, Johnston, Tera, additional, Giddings, Stephen, additional, Yamout, Hala, additional, Klein, Andrew, additional, Rowe, Caroline, additional, Vargo, Kristin, additional, Waidmann, Kristi, additional, Papademetriou, Vasilios, additional, Elkhoury, Jean Pierre, additional, Gregory, Barbara, additional, Amodeo, Susan, additional, Bloom, Mary, additional, Goldfarb-Waysman, Dalia, additional, Treger, Richard, additional, Kashefi, Mehran, additional, Huang, Christina, additional, Knibloe, Karen, additional, Ishani, Areef, additional, Slinin, Yelena, additional, Olney, Christine, additional, Rust, Jacqueline, additional, Fanti, Paolo, additional, Dyer, Christopher, additional, Bansal, Shweta, additional, Dunnam, Monica, additional, Hu, Lih-Lan, additional, and Zarate-Abbott, Perla, additional

Published
2022
Full Text
View/download PDF

68. Association of Intensive vs Standard Blood Pressure Control With Cerebral Blood Flow

Author

Dolui, Sudipto, primary, Detre, John A., additional, Gaussoin, Sarah A., additional, Herrick, Jennifer S., additional, Wang, Danny J. J., additional, Tamura, Manjula Kurella, additional, Cho, Monique E., additional, Haley, William E., additional, Launer, Lenore J., additional, Punzi, Henry A., additional, Rastogi, Anjay, additional, Still, Carolyn H., additional, Weiner, Daniel E., additional, Wright, Jackson T., additional, Williamson, Jeff D., additional, Wright, Clinton B., additional, Bryan, R. Nick, additional, Bress, Adam P., additional, Pajewski, Nicholas M., additional, and Nasrallah, Ilya M., additional

Published
2022
Full Text
View/download PDF

74. The geriatrics research instrument library: A resource for guiding instrument selection for researchers studying older adults with multiple chronic conditions

Author

Tisminetzky, Mayra, primary, Delude, Christopher, additional, Allore, Heather G, additional, Anzuoni, Kathryn, additional, Bloomstone, Sarah, additional, Charpentier, Peter, additional, Hepler, John P, additional, Kitzman, Dalane W, additional, McAvay, Gail J, additional, Miller, Michael, additional, Pajewski, Nicholas M, additional, and Gurwitz, Jerry, additional

Published
2022
Full Text
View/download PDF

75. Mild cognitive impairment and transitions in cognitive status in the Systolic Blood Pressure Intervention Trial (SPRINT)

Author

Gaussoin, Sarah A, primary, Pajewski, Nicholas M, additional, Chelune, Gordon, additional, Cleveland, Maryjo, additional, Crowe, Michael G, additional, Launer, Lenore J, additional, Lerner, Alan J, additional, Martindale‐Adams, Jennifer, additional, Nichols, Linda O, additional, Ogrocki, Paula K, additional, Sachs, Bonnie C, additional, Sink, Kaycee M, additional, Supiano, Mark A, additional, Wadley, Virginia G, additional, Wilson, Valerie M, additional, Wright, Clinton B, additional, Williamson, Jeff D, additional, Reboussin, David M, additional, and Rapp, Stephen R, additional

Published
2021
Full Text
View/download PDF

76. The PRagmatic EValuation of evENTs And Benefits of Lipid‐lowering in oldEr adults (PREVENTABLE) trial: Study design and procedures for cognitive assessment and adjudication

Author

Sachs, Bonnie C., primary, Rapp, Stephen R., additional, Kistler, Christine E, additional, Musi, Nicolas, additional, Supiano, Mark A., additional, Pajewski, Nicholas M., additional, Callahan, Kathryn E., additional, Alexander, Karen P., additional, Shah, Raj C, additional, Snyder, Heather M., additional, Carrillo, Maria C., additional, Espinoza, Sara, additional, and Williamson, Jeff D., additional

Published
2021
Full Text
View/download PDF

78. Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials

Author

Papandonatos, George D., Pan, Qing, Pajewski, Nicholas M., Delahanty, Linda M., Peter, Inga, Erar, Bahar, Ahmad, Shafqat, Harden, Maegan, Chen, Ling, Fontanillas, Pierre, Wagenknecht, Lynne E., Kahn, Steven E., Wing, Rena R., Jablonski, Kathleen A., Huggins, Gordon S., Knowler, William C., Florez, Jose C., McCaffery, Jeanne M., and Franks, Paul W.

Published
2015
Full Text
View/download PDF

79. Effect of intensive blood pressure control on subtypes of mild cognitive impairment and risk of progression from SPRINT study

Author

Gaussoin, Sarah A., primary, Pajewski, Nicholas M., additional, Chelune, Gordon, additional, Cleveland, Maryjo L., additional, Crowe, Michael G., additional, Launer, Lenore J., additional, Lerner, Alan J., additional, Martindale‐Adams, Jennifer, additional, Nichols, Linda O., additional, Ogrocki, Paula K., additional, Sachs, Bonnie C., additional, Sink, Kaycee M., additional, Supiano, Mark A., additional, Wadley, Virginia G., additional, Wilson, Valerie M., additional, Wright, Clinton B., additional, Williamson, Jeff D., additional, Reboussin, David M., additional, and Rapp, Stephen R., additional

Published
2021
Full Text
View/download PDF

80. Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT)

Author

Pajewski, Nicholas M., primary, Elahi, Fanny M., additional, Tamura, Manjula Kurella, additional, Hinman, Jason D., additional, Nasrallah, Ilya M., additional, Ix, Joachim H., additional, Miller, Lindsay M., additional, Launer, Lenore J., additional, Wright, Clinton B., additional, Supiano, Mark A., additional, Lerner, Alan J., additional, Sudduth, Tiffany L., additional, Killeen, Anthony A., additional, Cheung, Alfred K., additional, Reboussin, David M., additional, Wilcock, Donna M., additional, and Williamson, Jeff D., additional

Published
2021
Full Text
View/download PDF

84. Robust demographically-adjusted normative data for the Montreal Cognitive Assessment (MoCA): Results from the systolic blood pressure intervention trial

Author

Sachs, Bonnie C., primary, Chelune, Gordon J., additional, Rapp, Stephen R., additional, Couto, Ashley M., additional, Willard, James J., additional, Williamson, Jeff D., additional, Sink, Kaycee M., additional, Coker, Laura H., additional, Gaussoin, Sarah A., additional, Gure, Tanya R., additional, Lerner, Alan J., additional, Nichols, Linda O., additional, Still, Carolyn H., additional, Wadley, Virginia G., additional, and Pajewski, Nicholas M., additional

Published
2021
Full Text
View/download PDF

86. Robust demographically-adjusted normative data for the Montreal Cognitive Assessment (MoCA): Results from the systolic blood pressure intervention trial.

Author

Sachs, Bonnie C., Chelune, Gordon J., Rapp, Stephen R., Couto, Ashley M., Willard, James J., Williamson, Jeff D., Sink, Kaycee M., Coker, Laura H., Gaussoin, Sarah A., Gure, Tanya R., Lerner, Alan J., Nichols, Linda O., Still, Carolyn H., Wadley, Virginia G., and Pajewski, Nicholas M.

Subjects
MONTREAL Cognitive Assessment, SYSTOLIC blood pressure, REFERENCE values, OLDER people, RACE
Abstract

To generate robust, demographically-adjusted regression-based norms for the Montreal Cognitive Assessment (MoCA) using a large sample of diverse older US adults. Baseline MoCA scores were examined for participants in the Systolic Blood Pressure Intervention Trial (SPRINT). A robust, cognitively-normal sample was drawn from individuals not subsequently adjudicated with cognitive impairment through 4 years of follow-up. Multivariable Beta-Binomial regression was used to model the association of demographic variables with MoCA performance and to create demographically-stratified normative tables. Participants' (N = 5,338) mean age was 66.9 ± 8.8 years, with 35.7% female, 63.1% White, 27.4% Black, 9.5% Hispanic, and 44.5% with a college or graduate education. A large proportion scored below published MoCA cutoffs: 61.4% scored below 26 and 29.2% scored below 23. A disproportionate number falling below these cutoffs were Black, Hispanic, did not graduate from college, or were ≥75 years of age. Multivariable modeling identified education, race/ethnicity, age, and sex as significant predictors of MoCA scores (p<.001), with the best fitting model explaining 24.4% of the variance. Model-based predictions of median MoCA scores were generally 1 to 2 points lower for Black and Hispanic participants across combinations of age, sex, and education. Demographically-stratified norm-tables based on regression modeling are provided to facilitate clinical use, along with our raw data. By using regression-based strategies that more fully account for demographic variables, we provide robust, demographically-adjusted metrics to improve cognitive screening with the MoCA in diverse older adults. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

89. Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT).

Author

Pajewski, Nicholas M., Elahi, Fanny M., Tamura, Manjula Kurella, Hinman, Jason D., Nasrallah, Ilya M., Ix, Joachim H., Miller, Lindsay M., Launer, Lenore J., Wright, Clinton B., Supiano, Mark A., Lerner, Alan J., Sudduth, Tiffany L., Killeen, Anthony A., Cheung, Alfred K., Reboussin, David M., Wilcock, Donna M., and Williamson, Jeff D.

Abstract

Introduction: Lowering blood pressure (BP) reduces the risk for cognitive impairment and the progression of cerebral white matter lesions. It is unclear whether hypertension control also influences plasma biomarkers related to Alzheimer's disease and non‐disease‐specific neurodegeneration. Methods: We examined the effect of intensive (< 120 mm Hg) versus standard (< 140 mm Hg) BP control on longitudinal changes in plasma amyloid beta (Aβ)40 and Aβ42, total tau, and neurofilament light chain (NfL) in a subgroup of participants from the Systolic Blood Pressure Intervention Trial (N = 517). Results: Over 3.8 years, there were no significant between‐group differences for Aβ40, Aβ42, Aβ42/Aβ40, or total tau. Intensive treatment was associated with larger increases in NfL compared to standard treatment. Adjusting for kidney function, but not BP, attenuated the association between intensive treatment and NfL. Discussion: Intensive BP treatment was associated with changes in NfL, which were correlated with changes in kidney function associated with intensive treatment. Trial Registration: clinicaltrials.gov Identifier: NCT01206062 [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

90. Using an Electronic Health Record and Deficit Accumulation to Pragmatically Identify Candidates for Optimal Prescribing in Patients With Type 2 Diabetes.

Author

Callahan, Kathryn E., Lenoir, Kristin M., Usoh, Chinenye O., Williamson, Jeff D., Brown, LaShanda Y., Moses, Adam W., Hinely, Molly, Neuwirth, Zeev, and Pajewski, Nicholas M.

Subjects
SCIENTIFIC observation, CONFIDENCE intervals, IDENTIFICATION, CROSS-sectional method, PATIENTS, RETROSPECTIVE studies, TYPE 2 diabetes, RESEARCH funding, CHI-squared test, KAPLAN-Meier estimator, DESCRIPTIVE statistics, ELECTRONIC health records, MEDICAL prescriptions, PROPORTIONAL hazards models, PROBABILITY theory
Abstract

Objective: Despite guidelines recommending less stringent glycemic goals for older adults with type 2 diabetes, overtreatment is prevalent. Pragmatic approaches for prioritizing patients for optimal prescribing are lacking. We describe glycemic control and medication patterns for older adults with type 2 diabetes in a contemporary cohort, exploring variability by frailty status. Research Design and Methods: This was a cross-sectional observational study based on electronic health record (EHR) data, within an accountable care organization (ACO) affiliated with an academic medical center/health system. Participants were ACO-enrolled adults with type 2 diabetes who were ≥65 years of age as of 1 November 2020. Frailty status was determined by an automated EHR-based frailty index (eFI). Diabetes management was described by the most recent A1C in the past 2 years and use of higher-risk medications (insulin and/or sulfonylurea). Results: Among 16,973 older adults with type 2 diabetes (mean age 75.2 years, 9,154 women [53.9%], 77.8% White), 9,134 (53.8%) and 6,218 (36.6%) were classified as pre-frail (0.10 < eFI ≤0.21) or frail (eFI >0.21), respectively. The median A1C level was 6.7% (50 mmol/mol) with an interquartile range of 6.2–7.5%, and 74.1 and 38.3% of patients had an A1C <7.5% (58 mmol/mol) and <6.5% (48 mmol/mol), respectively. Frailty status was not associated with level of glycemic control (P = 0.08). A majority of frail patients had an A1C <7.5% (58 mmol/mol) (n = 4,544, 73.1%), and among these patients, 1,755 (38.6%) were taking insulin and/or a sulfonylurea. Conclusion: Treatment with insulin and/or a sulfonylurea to an A1C levels <7.5% is common in frail older adults. Tools such as the eFI may offer a scalable approach to targeting optimal prescribing interventions. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

92. Racial and ethnic disparities in nontraumatic dental-condition visits to emergency departments and physician offices: a study of the Wisconsin Medicaid program

Author

Okunseri, Christopher, Pajewski, Nicholas M., Brousseau, David C., Tomany-Korman, Sandy, Snyder, Andrew, and Flores, Glenn

Subjects
Dental emergencies -- Demographic aspects, Ethnic groups -- Health aspects, Hospitals -- Emergency service, Hospitals -- Demographic aspects, Medicaid -- Analysis, Health
Abstract

Analysis of all Medicaid dental claims in Wisconsin from 2001 to 2003 finds that Native Americans, those residing in dental health professional shortage areas, and adults have significantly higher risks of nontraumatic dental condition visits to emergency departments. Targeting educational strategies to minorities could reduce Medicaid visits.

Published
2008

93. Associations of Intensive Lifestyle Intervention in Type 2 Diabetes With Health Care Use, Spending, and Disability

Author

Huckfeldt, Peter J., Frenier, Chris, Pajewski, Nicholas M., Espeland, Mark, Peters, Anne, Casanova, Ramon, Pi-Sunyer, Xavier, Cheskin, Lawrence, and Goldman, Dana P.

Subjects
Counseling, Male, Medicare Part D, Eligibility Determination, Medicare, Disability Evaluation, Behavior Therapy, Humans, Life Style, Original Investigation, Aged, Glycated Hemoglobin, Research, Body Weight, Health Care Costs, Health Services, Middle Aged, United States, Exercise Therapy, Hospitalization, Online Only, Diabetes and Endocrinology, Diabetes Mellitus, Type 2, Female, Medicare Part B, Medicare Part A, Health Expenditures, Emergency Service, Hospital, Diet Therapy
Abstract

Key Points Question Is an intensive lifestyle intervention for type 2 diabetes associated with long-term health care use and Medicare spending? Findings This ancillary study of a randomized clinical trial linked 2796 participants with type 2 diabetes in a randomized intensive lifestyle intervention with Medicare data. Among linked participants, the intervention was associated with reduced weight, improved diabetes control, and reduced health care costs during the intervention, but there was no reduction in total health care spending after the intervention. Meaning These findings suggest that intensive lifestyle interventions targeted to patients with type 2 diabetes may need to be sustained to reduce long-term health care spending., This ancillary study of a randomized clinical trial examines the long-term associations of an intensive lifestyle intervention for type 2 diabetes with health care use, spending, and disability., Importance Intensive lifestyle interventions focused on diet and exercise can reduce weight and improve diabetes management. However, the long-term effects on health care use and spending are unclear, especially for public payers. Objective To estimate the association of effective intensive lifestyle intervention for weight loss with long-term health care use and Medicare spending. Design, Setting, and Participants This ancillary study used data from the Look AHEAD randomized clinical trial, which randomized participants with type 2 diabetes to an intensive lifestyle intervention or control group (ie, diabetes support and education), provided ongoing intervention from 2001 to 2012, and demonstrated improved diabetes management and reduced health care costs during the intervention. This study compared Medicare data between study arms from 2012 to 2015 to determine whether the intervention was associated with persistent reductions in health care spending. Exposure Starting in 2001, Look AHEAD’s intervention group participated in sessions with lifestyle counselors, dieticians, exercise specialists, and behavioral therapists with the goal of reducing weight 7% in the first year. Sessions occurred weekly in the first 6 months of the intervention and decreased over the intervention period. The controls participated in periodic group education sessions that occurred 3 times per year in the first year and decreased to 1 time per year later in the trial. Main Outcomes and Measures Outcomes included total Medicare spending, Part D prescription drug costs, Part A and Part B Medicare spending, hospital admissions, emergency department visits, and disability-related Medicare eligibility. Results This study matched Medicare administrative records for 2796 Look AHEAD study participants (54% of 5145 participants initially randomized and 86% of 3246 participants consenting to linkages). Linked intervention and control participants were of a similar age (mean [SD] age, 59.6 [5.4] years vs 59.6 [5.5] years at randomization) and sex (818 [58.1%] women vs 822 [59.3%] women). There was no statistically significant difference in total Medicare spending between groups (difference, −$133 [95% CI, −$1946 to $1681]; P = .89). In the intervention group, compared with the control group, there was statistically significantly higher Part B spending (difference, $513 [95% CI, $70 to $955]; P = .02) but lower prescription drug costs (difference, −$803 [95% CI, −$1522 to −$83]; P = .03). Conclusions and Relevance This ancillary study of a randomized clinical trial found that reductions in health care use and spending associated with an intensive lifestyle intervention for type 2 diabetes diminished as participants aged. Intensive lifestyle interventions may need to be sustained to reduce long-term health care spending. Trial Registration ClinicalTrials.gov Identifier: NCT03952728

Published
2020

95. Automated Frailty Screening At‐Scale for Pre‐Operative Risk Stratification Using the Electronic Frailty Index

Author

Callahan, Kathryn E., primary, Clark, Clancy J., additional, Edwards, Angela F., additional, Harwood, Timothy N., additional, Williamson, Jeff D., additional, Moses, Adam W., additional, Willard, James J., additional, Cristiano, Joseph A., additional, Meadows, Kellice, additional, Hurie, Justin, additional, High, Kevin P., additional, Meredith, J. Wayne, additional, and Pajewski, Nicholas M., additional

Published
2021
Full Text
View/download PDF

98. Concordance Between Blood Pressure in the Systolic Blood Pressure Intervention Trial and in Routine Clinical Practice

Author

Drawz, Paul E., primary, Agarwal, Anil, additional, Dwyer, Jamie P., additional, Horwitz, Edward, additional, Lash, James, additional, Lenoir, Kristin, additional, McWilliams, Andrew, additional, Oparil, Suzanne, additional, Rahbari-Oskoui, Frederic, additional, Rahman, Mahboob, additional, Parkulo, Mark A., additional, Pemu, Priscilla, additional, Raj, Dominic S., additional, Rocco, Michael, additional, Soman, Sandeep, additional, Thomas, George, additional, Tuot, Delphine S., additional, Whelton, Paul K., additional, and Pajewski, Nicholas M., additional

Published
2020
Full Text
View/download PDF

99. Fluid biomarkers of Alzheimer’s disease in the Systolic Blood Pressure Intervention Trial

Author

Pajewski, Nicholas M, primary, Elahi, Fanny M, additional, Ix, Joachim H, additional, Nasrallah, Ilya M, additional, Reboussin, David M, additional, Tamura, Manjula Kurella, additional, Wright, Clinton B, additional, Hinman, Jason, additional, Miller, Lindsay M, additional, Sudduth, Tiffany L, additional, Wilcock, Donna M, additional, and Williamson, Jeff D, additional

Published
2020
Full Text
View/download PDF

100. Effect of intensive blood pressure control on subtypes of mild cognitive impairment and risk of progression from SPRINT study.

Author

Gaussoin, Sarah A., Pajewski, Nicholas M., Chelune, Gordon, Cleveland, Maryjo L., Crowe, Michael G., Launer, Lenore J., Lerner, Alan J., Martindale‐Adams, Jennifer, Nichols, Linda O., Ogrocki, Paula K., Sachs, Bonnie C., Sink, Kaycee M., Supiano, Mark A., Wadley, Virginia G., Wilson, Valerie M., Wright, Clinton B., Williamson, Jeff D., Reboussin, David M., and Rapp, Stephen R.

Subjects
*MILD cognitive impairment, *REGULATION of blood pressure, *DISEASE progression, *SYSTOLIC blood pressure, *HYPERTENSION, *DEMENTIA risk factors
Abstract

Background: To examine the effect of intensive blood pressure control on the occurrence of subtypes of mild cognitive impairment (MCI) and determine the risk of progression to dementia or death. Methods: Secondary analysis of a randomized trial of community‐dwelling adults (≥50 years) with hypertension. Participants were randomized to a systolic blood pressure (SBP) goal of <120 mm Hg (intensive treatment; n = 4678) or <140 mm Hg (Standard treatment; n = 4683). Outcomes included adjudicated MCI, MCI subtype (amnestic, non‐amnestic, multi‐domain, single domain), and probable dementia. Multistate survival models were used to examine transitions in cognitive status accounting for the competing risk of death. Results: Among 9361 randomized participants (mean age, 67.9 years; 3332 women [35.6%]), 640 participants met the protocol definition for MCI, with intensive treatment reducing the risk of MCI overall (hazard ratio [HR], 0.81 [95% confidence interval {CI}, 0.69–0.94]), as previously reported. This effect was largely reflected in amnestic subtypes (HR, 0.78 [95% CI, 0.66–0.92]) and multi‐domain subtypes (HR, 0.78 [95% CI, 0.65–0.93]). An adjudication of MCI, as compared with normal cognitive function, substantially increased the probability of progressing to probable dementia (5.9% [95% CI: 4.5%–7.7%] vs. 0.6% [95% CI: 0.3%–0.9%]) and to death (10.0% [95% CI: 8.3%–11.9%] vs. 2.3% [95% CI: 2.0%–2.7%]) within 2 years. Conclusions: Intensive treatment reduced the risk for amnestic and multi‐domain subtypes of MCI. An adjudication of MCI was associated with increased risk of progression to dementia and death, highlighting the relevance of MCI as a primary outcome in clinical and research settings. See related Editorial by Deardorff et al. in this issue. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results