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51. Contributors

Author

Accardi, Giulia, primary, Aiello, Anna, additional, De Biasi, Sara, additional, Bono, Filippa, additional, Bryl, Ewa, additional, Busetta, Annalisa, additional, Calabrese, Edward, additional, Calabrese, Vittorio, additional, Candore, Giuseppina, additional, Carru, Ciriaco, additional, Caruso, Calogero, additional, Cicero, Arrrgo F.G., additional, Colletti, Alessandro, additional, Coplen, Christopher P., additional, Cossarizza, Andrea, additional, Craxì, Lucia, additional, Crocco, Paolina, additional, Dato, Serena, additional, Davinelli, Sergio, additional, Fidanza, Lucia, additional, Fulop, Tamas, additional, De Gaetano, Anna, additional, Galimberti, Damiano, additional, Gibellini, Lara, additional, Iannone, Francesca, additional, Jergović, Mladen, additional, Ligotti, Mattia Emanuela, additional, Lo Tartaro, Domenico, additional, Mattioli, Marco, additional, Mazzola, Giuseppe, additional, Nasi, Milena, additional, Nikolich-Žugich, Janko, additional, Olivieri, Fabiola, additional, Ontario, Maria Laura, additional, Passarino, Giuseppe, additional, Pawelec, Graham, additional, Perrotta, Rosario, additional, Pinti, Marcello, additional, Procopio, Antonio Domenico, additional, Rippo, Maria Rita, additional, Romanelli, Francesco, additional, Rose, Giuseppina, additional, Sansone, Andrea, additional, Scapagnini, Giovanni, additional, Scuto, Maria, additional, Tomasello, Mario, additional, Trovato, Angela, additional, Vasto, Sonya, additional, Witkowski, Jacek M., additional, and Wu, Lu, additional

Published
2021
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58. A novel series of conferences tackling the hurdles confronting the translation of novel cancer immunotherapies

Author

Bot, Adrian, Ahn, Mark, Bosch, Marnix, Brockstedt, Dirk, Butterfield, Lisa H, Cornforth, Andrew, Harrop, Richard, Kast, W, Koya, Richard, Marincola, Francesco, Margolin, Kim, McCoy, Candice, Pawelec, Graham, Rothman, John, Ramirez-Montagut, Teresa, Schlom, Jeffrey, Srivastava, Pramod, Wallis, Sarah, Walter, Steffen, Wang, Ena, and Waslif, John

Abstract

Abstract While there has been significant progress in advancing novel immune therapies to the bedside, much more needs to be done to fully tap into the potential of the immune system. It has become increasingly clear that besides practical and operational challenges, the heterogeneity of cancer and the limited efficacy profile of current immunotherapy platforms are the two main hurdles. Nevertheless, the promising clinical data of several approaches point to a roadmap that carries the promise to significantly advance cancer immunotherapy. A new annual series sponsored by Arrowhead Publishers and Conferences aims at bringing together scientific and business leadership from academia and industry, to identify, share and discuss most current priorities in research and translation of novel immune interventions. This Editorial provides highlights of the first event held earlier this year and outlines the focus of the second meeting to be held in 2013 that will be dedicated to stem cells and immunotherapy.

Published
2012

59. Defining the Critical Hurdles in Cancer Immunotherapy

Author

Fox, Bernard A, Schendel, Dolores J, Butterfield, Lisa H, Aamdal, Steinar, Allison, James P, Ascierto, Paolo, Atkins, Michael B, Bartunkova, Jirina, Bergmann, Lothar, Berinstein, Neil, Bonorino, Cristina C, Borden, Ernest, Bramson, Jonathan L, Britten, Cedrik M, Cao, Xuetao, Carson, William E, Chang, Alfred E, Characiejus, Dainius, Choudhury, A Raja, Coukos, George, de Gruijl, Tanja, Dillman, Robert O, Dolstra, Harry, Dranoff, Glenn, Durrant, Lindy G, Finke, James H, Galon, Jerome, Gollob, Jared A, Gouttefangeas, Cécile, Grizzi, Fabio, Guida, Michele, Håkansson, Leif, Hege, Kristen, Herberman, Ronald B, Hodi, F Stephen, Hoos, Axel, Huber, Christoph, Hwu, Patrick, Imai, Kohzoh, Jaffee, Elizabeth M, Janetzki, Sylvia, June, Carl H, Kalinski, Pawel, Kaufman, Howard L, Kawakami, Koji, Kawakami, Yutaka, Keilholtz, Ulrich, Khleif, Samir N, Kiessling, Rolf, Kotlan, Beatrix, Kroemer, Guido, Lapointe, Rejean, Levitsky, Hyam I, Lotze, Michael T, Maccalli, Cristina, Maio, Michele, Marschner, Jens-Peter, Mastrangelo, Michael J, Masucci, Giuseppe, Melero, Ignacio, Melief, Cornelius, Murphy, William J, Nelson, Brad, Nicolini, Andrea, Nishimura, Michael I, Odunsi, Kunle, Ohashi, Pamela S, O'Donnell-Tormey, Jill, Old, Lloyd J, Ottensmeier, Christian, Papamichail, Michael, Parmiani, Giorgio, Pawelec, Graham, Proietti, Enrico, Qin, Shukui, Rees, Robert, Ribas, Antoni, Ridolfi, Ruggero, Ritter, Gerd, Rivoltini, Licia, Romero, Pedro J, Salem, Mohamed L, Scheper, Rik J, Seliger, Barbara, Sharma, Padmanee, Shiku, Hiroshi, Singh-Jasuja, Harpreet, Song, Wenru, Straten, Per, Tahara, Hideaki, Tian, Zhigang, van Der Burg, Sjoerd H, von Hoegen, Paul, Wang, Ena, Welters, Marij JP, Winter, Hauke, Withington, Tara, Wolchok, Jedd D, Xiao, Weihua, and Zitvogel, Laurence

Abstract

Abstract Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a scientific basis, others do not. We need to do better. Innovative strategies need to move into early stage clinical trials as quickly as it is safe, and if successful, these therapies should efficiently obtain regulatory approval and widespread clinical application. In late 2009 and 2010 the Society for Immunotherapy of Cancer (SITC), convened an "Immunotherapy Summit" with representatives from immunotherapy organizations representing Europe, Japan, China and North America to discuss collaborations to improve development and delivery of cancer immunotherapy. One of the concepts raised by SITC and defined as critical by all parties was the need to identify hurdles that impede effective translation of cancer immunotherapy. With consensus on these hurdles, international working groups could be developed to make recommendations vetted by the participating organizations. These recommendations could then be considered by regulatory bodies, governmental and private funding agencies, pharmaceutical companies and academic institutions to facilitate changes necessary to accelerate clinical translation of novel immune-based cancer therapies. The critical hurdles identified by representatives of the collaborating organizations, now organized as the World Immunotherapy Council, are presented and discussed in this report. Some of the identified hurdles impede all investigators; others hinder investigators only in certain regions or institutions or are more relevant to specific types of immunotherapy or first-in-humans studies. Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet if overcome, have the potential to improve outcomes of patients with cancer.

Published
2011

60. Aging and chronic inflammation: highlights from a multidisciplinary workshop

Author

Saavedra, Danay, Añé-Kourí, Ana Laura, Barzilai, Nir, Caruso, Calogero, Cho, Kyung-Hyun, Fontana, Luigi, Franceschi, Claudio, Frasca, Daniela, Ledón, Nuris, Niedernhofer, Laura J., Pereira, Karla, Robbins, Paul D., Silva, Alexa, Suarez, Gisela M., Vanden Berghe, Wim, von Zglinicki, Thomas, Pawelec, Graham, Lage, Agustín, Saavedra, Danay, Añé-Kourí, Ana Laura, Barzilai, Nir, Caruso, Calogero, Cho, Kyung-Hyun, Fontana, Luigi, Franceschi, Claudio, Frasca, Daniela, Ledón, Nuri, Niedernhofer, Laura J, Pereira, Karla, Robbins, Paul D, Silva, Alexa, Suarez, Gisela M, Berghe, Wim Vanden, von Zglinicki, Thoma, Pawelec, Graham, and Lage, Agustín

Subjects
Settore MED/04 - Patologia Generale, Aging, Biomodulina T, Immunosenescence, Cell senescence, Senolytic, Human medicine, Chronic inflammation, SASP, Biology, Inflammaging, Metformin
Abstract

Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic antigenic stress notably caused by chronic infections such as cytomegalovirus (CMV), and immune cell senescence with acquisition of an inflammatory senescence-associated secretory phenotype (SASP). For this reason, and due to the SASP originating from other tissues, aging is commonly accompanied by low-grade chronic inflammation, termed “inflammaging”. After decades of accumulating evidence regarding age-related processes and chronic inflammation, the domain now appears mature enough to allow an integrative reinterpretation of old data. Here, we provide an overview of the topics discussed in a recent workshop “Aging and Chronic Inflammation” to which many of the major players in the field contributed. We highlight advances in systematic measurement and interpretation of biological markers of aging, as well as their implications for human health and longevity and the interventions that can be envisaged to maintain or improve immune function in older people.

Published
2023

65. Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients

Author

Wistuba-Hamprecht, Kilian, Martens, Alexander, Heubach, Florian, Romano, Emanuela, Geukes Foppen, Marnix, Yuan, Jianda, Postow, Michael, Wong, Phillip, Mallardo, Domenico, Schilling, Bastian, Di Giacomo, Anna Maria, Khammari, Amir, Dreno, Brigitte, Maio, Michele, Schadendorf, Dirk, Ascierto, Paolo A., Wolchok, Jedd D., Blank, Christian U., Garbe, Claus, Pawelec, Graham, and Weide, Benjamin

Published
2017
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69. Contributors

Author

Abers, Michael S., primary, Babushok, Daria V., additional, Ballow, Mark, additional, Boisson, Bertrand, additional, Bonagura, Vincent Robert, additional, Bonilla, Francisco A., additional, Bosco de Oliveira Filho, João, additional, Boztug, Kaan, additional, Broderick, Lori, additional, Butte, Manish J., additional, Candotti, Fabio, additional, Casanova, Jean-Laurent, additional, Chandrakasan, Shanmuganathan, additional, Condino-Neto, Antonio, additional, Crow, Yanick J., additional, Cunningham-Rundles, Charlotte, additional, Dalm, Virgil A.S.H., additional, de Jesus, Adriana A., additional, de Maio, Emma, additional, de Saint Basile, Geneviève, additional, de Vries, Esther, additional, Dokal, Inderjeet, additional, Duncan, Christopher J.A., additional, Durandy, A., additional, Ehl, Stephan, additional, Etzioni, Amos, additional, Ferguson, Polly J., additional, Fleisher, Thomas A., additional, Forbes-Satter, Lisa R., additional, Frank, Michael M., additional, Freeman, Alexandra F., additional, Frémond, Marie-Louise, additional, Frew, John W., additional, Fusaro, Mathieu, additional, Gambineri, Eleonora, additional, Ganetzky, Rebecca D., additional, Gennery, Andrew R., additional, Goldbach-Mansky, Raphaela, additional, Goldstein, Amy C., additional, Graham, John M., additional, Gupton, Stephanie E., additional, Haddad, Elie, additional, Hambleton, Sophie, additional, Hanson, Eric P., additional, Heimall, Jennifer, additional, Helfrich, Miep, additional, Henrickson, Sarah E., additional, Holland, Steven M., additional, Hsu, Amy P., additional, Jyonouchi, Soma, additional, Kashef, Sara, additional, Kelsen, Judith, additional, Khalil, Maya, additional, Klein, Christoph, additional, Kobrynski, Lisa, additional, Kohn, Donald B., additional, Kracker, S., additional, Krueger, James G., additional, Lavoie, Pascal M., additional, Lehman, Heather K., additional, Leiding, Jennifer W., additional, Lenardo, Michael J., additional, Levy, Ofer, additional, Lim, Allison Pecha, additional, Lionakis, Michail S., additional, Lisco, Andrea, additional, Lougaris, Vassilios, additional, Lugo Reyes, Saul O., additional, Markert, M. Louise, additional, Marsh, Rebecca A., additional, McCarthy, Elizabeth A., additional, Meyts, Isabelle, additional, Milito, Cinzia, additional, Milner, Joshua D., additional, Ming, Jeffrey E., additional, Moshous, Despina, additional, Müller, Ludmila, additional, Navrazhina, Kristina, additional, Nichols, Kim E., additional, Notarangelo, Luigi D., additional, Oksenhendler, Eric, additional, Orange, Jordan S., additional, Paganelli, Roberto, additional, Pawelec, Graham, additional, Pentimalli, Tancredi Massimo, additional, Perez, Elena E., additional, Picard, Capucine, additional, Plebani, Alessandro, additional, Porras, Oscar, additional, Przespolewski, Amanda C., additional, Puel, Anne, additional, Pulvirenti, Federica, additional, Quinti, Isabella, additional, Rezaei, Nima, additional, Rijkers, Ger T., additional, Rosenthal, David Walter, additional, Rosenzweig, Sergio D., additional, Segal, Brahm H., additional, Seppänen, Mikko R.J., additional, Sereti, Irini, additional, Shcherbina, Anna, additional, Sobacchi, Cristina, additional, Squire, Jacqueline D., additional, Stepensky, Polina, additional, Su, Helen C., additional, Sullivan, Kathleen E., additional, Torgerson, Troy R., additional, Uzel, Gulbu, additional, van der Burg, Mirjam, additional, Villa, Anna, additional, Villartay, Jean-Pierre de, additional, Warnatz, Klaus, additional, Wasserman, Richard L., additional, Weemaes, Corry M.R., additional, Yu, Joyce E., additional, Zhang, Shen-Ying, additional, and Ziegler, John B., additional

Published
2020
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78. Early decrease of blood myeloid-derived suppressor cells during checkpoint inhibition is a favorable biomarker in metastatic melanoma

Author

Gaißler, Andrea, primary, Bochem, Jonas, additional, Spreuer, Janine, additional, Ottmann, Shannon, additional, Martens, Alexander, additional, Amaral, Teresa, additional, Wagner, Nikolaus Benjamin, additional, Claassen, Manfred, additional, Meier, Friedegund, additional, Terheyden, Patrick, additional, Garbe, Claus, additional, Eigentler, Thomas, additional, Weide, Benjamin, additional, Pawelec, Graham, additional, and Wistuba-Hamprecht, Kilian, additional

Published
2023
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80. Proportions of blood-borne Vδ1+ and Vδ2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab

Author

Wistuba-Hamprecht, Kilian, Martens, Alexander, Haehnel, Karin, Geukes Foppen, Marnix, Yuan, Jianda, Postow, Michael A., Wong, Phillip, Romano, Emanuela, Khammari, Amir, Dreno, Brigitte, Capone, Mariaelena, Ascierto, Paolo A., Demuth, Ilja, Steinhagen-Thiessen, Elisabeth, Larbi, Anis, Schilling, Bastian, Schadendorf, Dirk, Wolchok, Jedd D., Blank, Christian U., Pawelec, Graham, Garbe, Claus, and Weide, Benjamin

Published
2016
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93. Berlin Aging Study II (BASE-II)

Author

Demuth, Ilja, primary, Bertram, Lars, additional, Drewelies, Johanna, additional, Düzel, Sandra, additional, Lill, Christina M., additional, Lindenberger, Ulman, additional, Pawelec, Graham, additional, Spira, Dominik, additional, Wagner, Gert G., additional, and Gerstorf, Denis, additional

Published
2019
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95. Immunological Theory of Aging

Author

Fulop, Tamas, primary, Witkowski, Jacek M., additional, Larbi, Anis, additional, Cohen, Alan A., additional, Frost, Eric, additional, and Pawelec, Graham, additional

Published
2019
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99. Data from Intralesional Treatment of Stage III Metastatic Melanoma Patients with L19–IL2 Results in Sustained Clinical and Systemic Immunologic Responses

Author

Weide, Benjamin, primary, Eigentler, Thomas K., primary, Pflugfelder, Annette, primary, Zelba, Henning, primary, Martens, Alexander, primary, Pawelec, Graham, primary, Giovannoni, Leonardo, primary, Ruffini, Pier Adelchi, primary, Elia, Giuliano, primary, Neri, Dario, primary, Gutzmer, Ralf, primary, Becker, Jürgen C., primary, and Garbe, Claus, primary

Published
2023
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100. Supplementary Methods from Intralesional Treatment of Stage III Metastatic Melanoma Patients with L19–IL2 Results in Sustained Clinical and Systemic Immunologic Responses

Author

Weide, Benjamin, primary, Eigentler, Thomas K., primary, Pflugfelder, Annette, primary, Zelba, Henning, primary, Martens, Alexander, primary, Pawelec, Graham, primary, Giovannoni, Leonardo, primary, Ruffini, Pier Adelchi, primary, Elia, Giuliano, primary, Neri, Dario, primary, Gutzmer, Ralf, primary, Becker, Jürgen C., primary, and Garbe, Claus, primary

Published
2023
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