595 results on '"P. Sève"'
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52. Lettre à l’éditeur : qu’apportent les nouvelles recommandations sur le diagnostic et le traitement de la sarcoïdose ? Prise en compte de l’hypothèse « poussière ». M. Vincent, M. Catinon
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P. Sève and T. El Jammal
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Gastroenterology ,Internal Medicine - Published
- 2022
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53. Effet bénéfique du traitement immunosuppresseur dans les uvéites non-antérieures de la sarcoïdose
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M. Leclercq, P. Sève, L. Biard, M. Vautier, F. Domont, G. Maalouf, G. Leroux, A. Toutée, C. Fardeau, S. Touhami, B. Bodaghi, L. Kodjikian, P. Cacoub, D. Saadoun, and A.C. Desbois
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Gastroenterology ,Internal Medicine - Published
- 2022
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54. [Hydroxychloroquine for non-severe extra-pulmonary sarcoidosis]
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Y, Jamilloux, T, El Jammal, A, Bert, and P, Sève
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Sarcoidosis ,Sarcoidosis, Pulmonary ,Adrenal Cortex Hormones ,Humans ,Steroids ,Hydroxychloroquine - Abstract
Sarcoidosis can develop into a chronic disease in about 30% of cases. When general treatment is indicated, corticosteroids are the first-line treatment. More than one third of patients treated with corticosteroids receive a steroid-sparing agent. Although methotrexate is the most commonly used sparing agent, synthetic antimalarials have been used for more than fifty years on the basis of small, randomised, therapeutic trials. Despite this low level of evidence, chloroquine or more often hydroxychloroquine are used in daily practice, particularly to treat skin, bone and joint sarcoidosis, as well as hypercalcemia and certain types of uveitis. This review summarises the state of knowledge on steroid-sparing therapy in sarcoidosis, particularly in its extra-pulmonary form. These data support the need for good quality therapeutic trials to validate the use of hydroxychloroquine in this specific indication.
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- 2021
55. [Importance of cognitive disorders in internal medicine: Pathophysiology, diagnosis, management. The example of systemic lupus erythematosus]
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E, Peter, M, Robert, V, Guinet, P, Krolak-Salmon, V, Desestret, S, Jacquin-Courtois, F, Cohen, P, Sève, and A, Garnier-Crussard
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Cognition ,Lupus Vasculitis, Central Nervous System ,Internal Medicine ,Quality of Life ,Humans ,Lupus Erythematosus, Systemic ,Neuropsychological Tests ,Cognition Disorders - Abstract
Systemic diseases, which are in France mainly monitored in internal medicine, affect multiple organs or tissues. While cutaneous or articular manifestations are the most common, neurological involvement is often associated with severity. Diagnosis of peripheral (e.g, neuropathies) or central (e.g, myelitis) nervous disorders is quite easy through clinical examination and dedicated complementary tests. However, neuropsychological manifestations that affect cognition, including memory, attention, executive functions or reasoning, are difficult to diagnose, sometimes trivialized by practitioners. Their causes are often numerous and interrelated. Nevertheless, these cognitive manifestations are closely related to patients' quality of life, affecting their social life, family dynamics and professional integration but also the treatment adherence. The purpose of this review, focused on the example of systemic lupus erythematosus, is to raise awareness of cognitive dysfunction in systemic diseases including their management from diagnosis to treatments. The final aim is to go further into setting up research groups and care programs for patients with cognitive impairment followed in internal medicine.
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- 2021
56. Utilisation de la téléconsultation par les allergologues : résultats de l'enquête du CNPA de 2021.
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Sève, E., Fromentin, E., Bossé, I., Canipel, L., Lefèvre, S., and Demoly, P.
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La téléconsultation est un acte médical pris en charge par la sécurité sociale pour le suivi des patients depuis 2018 mais qui a connu un essor phénoménal avec la crise COVID de 2020. Le Conseil National Professionnel d'Allergologie a souhaité enquêter auprès de ses membres à ce propos. 82,1 % n'utilisait pas cet outil avant la crise mais pendant celle-ci 86,4 % des médecins l'ont fait et 66,8 % le font encore en 2021. La téléconsultation leur sert principalement pour le renouvellement d'une immunothérapie allergénique, de traitements symptomatiques et pour annoncer un bilan biologique. Un allergologue sur deux trouve "intéressant" le fait de pouvoir recevoir ainsi des nouveaux patients, notamment pour des patients dans un désert médical, une histoire d'allergie médicamenteuse ou une urticaire chronique. 57,3 % pensent gagner du temps grâce à la téléconsultation. On note ainsi que cet exercice de la médecine à distance est rentré dans les habitudes des allergologues qui ont su se l'approprier et l'adapter à leur pratique. Teleconsultation has been a reimbursed tool for monitoring patients since 2018 but which experienced a phenomenal boom with the COVID crisis of 2020. The National Professional Council of Allergology wanted to survey its members in this regard. 82.1% did not use this tool before the crisis but during it 86.4% of the doctors did it and 66.8% still do it in 2021. The teleconsultation is used mainly for the renewal of an allergen immunotherapy, symptomatic treatments and to announce a biological assessment. One in two allergists find it "interesting" to be able to receive new patients in this way, especially for patients in a medical desert, with a history of drug allergy or chronic urticaria. 57.3% think they save time thanks to teleconsultation. We note that this tool has become a habit of allergists who have known how to appropriate and adapt it to their practice. [ABSTRACT FROM AUTHOR]
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- 2022
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57. État des connaissances et besoins en formation en biologie de l'allergie : enquête du Groupe de Travail Biologie de l'Allergie de la Société française d'allergologie à l'intention des jeunes allergologues.
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Goret, J., Sève, E., and Klingebiel, C.
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La biologie est un outil incontournable dans le diagnostic et la prise en charge des patients allergiques. L'apprentissage à l'interprétation d'un bilan biologique est essentiel pour le praticien. En raison de la diversité des cursus, les jeunes allergologues n'ont pas tous la même formation. À la demande du Conseil Scientifique de la Société française d'allergologie (SFA), le Groupe de Travail Biologie de l'Allergie a réalisé une enquête auprès des jeunes allergologues afin d'évaluer leur niveau de formation en biologie de l'allergie et de connaître leurs attentes en termes de formation continue. Au total, 162 allergologues ont été contactés et 36 ont répondu. Les répondants étaient majoritairement des femmes (78 %), allergologues exclusifs (83 %) et 69 % étaient issus du DES d'Allergologie. La moitié estimait avoir eu une formation suffisante en biologie de l'allergie et 50 % ont effectué un stage dans un laboratoire de biologie médicale. Soixante-trois pour cent se considéraient comme compétents pour l'interprétation des bilans. Pour leur formation continue, ils utilisaient les sites internet des sociétés savantes, les revues scientifiques et des webinaires qu'ils jugeaient satisfaisants. Aucune personne n'avait recours à un système d'évaluation des compétences. Plus de 95 % des répondants sont en faveur d'une mise à disposition de documents synthétiques de référence et tous les consulteraient s'ils étaient accessibles en ligne sur le site de la SFA. En conclusion, la formation des jeunes allergologues sur la biologie de l'allergie a besoin d'être complétée et harmonisée, sur le plan théorique et pratique. Plusieurs outils pédagogiques sont plébiscités pour le maintien des compétences. Blood tests are an essential tool for the diagnosis and management of allergy. Learning how to interpret test results is therefore essential for the physician. Due to the diversity of their education, young allergists do not all have the same training. At the request of the French Society of Allergology (SFA) Scientific Committee, the In vitro Diagnosis Working Group carried out a survey for young allergists in order to evaluate their level of initial training in allergy in vitro diagnosis and to know their expectations in terms of continuing medical education. A total of 162 allergists were consulted and 36 responded. Half of them considered that they had sufficient training in allergy in vitro diagnosis and 50% considered themselves competent in the interpretation of tests. For their continuing medical education, they use the websites of learned societies (SFA, EEACI), scientific journals and webinars and consider them satisfactory or very satisfactory. More than 95% of them are in favour of the online availability of summary sheets or reference documents in in vitro diagnosis, and all of them would consult these tools if they were accessible on the SFA website. In conclusion, the training of young allergists in allergy blood tests needs to be completed and standardised, both theoretically and practically. Several educational tools are available and popular to achieve this and help them to keep valuable skills up to date. [ABSTRACT FROM AUTHOR]
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- 2022
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58. Elderly-Onset Sarcoidosis: Prevalence, Clinical Course, and Treatment
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Jamilloux, Yvan, Bonnefoy, Marc, Valeyre, Dominique, Varron, Loig, Broussolle, Christiane, and Sève, Pascal
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- 2013
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59. [Towards a better recognition of cognitive disorders in internal medicine?]
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E, Peter, M, Robert, V, Guinet, P, Krolak-Salmon, V, Desestret, S, Jacquin-Courtois, F, Cohen, P, Sève, and A, Garnier-Crussard
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Cognition ,Internal Medicine ,Humans ,Cognition Disorders - Published
- 2021
60. Long-distance energy transfer photosensitizers arising in hybrid nanoparticles leading to fluorescence emission and singlet oxygen luminescence quenching
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Sève, Aymeric, Couleaud, Pierre, Lux, François, Tillement, Olivier, Arnoux, Philippe, André, Jean-Claude, and Frochot, Céline
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- 2012
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61. Sprint running performance: comparison between treadmill and field conditions
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Morin, Jean-Benoît and Sève, Pierrick
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- 2011
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62. Uvéites chez les patients vivant avec le VIH : une étude rétrospective multicentrique
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M. Razafinimanana, L. Benjamin, D. Saadoun, B. Bodaghi, A. Toutée, E. Caumes, C. Katlama, V. Pourcher, P. Sève, L. Cotte, L. Kodjikian, Y. Serrar, H. Devilliers, P. Bielefeld, S. Mouries-Martin, R. Jaussaud, K. Angioi-Duprez, and T. Moulinet
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Gastroenterology ,Internal Medicine - Published
- 2022
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63. Pronostic à long terme des choriorétinopathies de Birdshot traitées par corticoïdes : étude rétrospective de cohorte
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D. Ferracci, T. Mathis, A. Gavoille, M. Gerfaud-Valentin, L. Kodjikian, and P. Sève
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Gastroenterology ,Internal Medicine - Published
- 2022
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64. Facteurs histologiques associés à une complication hépatique au cours de la sarcoïdose hépatique : analyse descriptive anatomoclinique à partir d’une cohorte multicentrique de 92 patients
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G. Rossi, M. Ziol, M. Fauter, A. Mirouse, V. Hervieu, J. Calderaro, S. Isaac, D. Bouvry, B. Godeau, D. Roulot-Marullo, D. Valeyre, P. Sève, and M. Mahevas
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Gastroenterology ,Internal Medicine - Published
- 2022
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65. Récepteur soluble de l’interleukine 2 au cours de la sarcoïdose : vers un nouveau biomarqueur d’activité et de suivi ?
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V. Pagis, P. Sève, L. Garnier, C. Bulteau, C. Comarmond, A. Vanjak, K. Champion, R. Burlacu, A. Lopes, W. Bigot, K. Nassarmadji, S. Mouly, and D. Sene
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Gastroenterology ,Internal Medicine - Published
- 2022
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66. Facteurs pronostiques des carcinomes de primitif inconnu
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Sève, P. and Culine, S.
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- 2008
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67. [Observational study of QuantiFERON® management for ocular tuberculosis diagnosis: Analysis of 244 consecutive tests]
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A, Amara, E, Ben Salah, A, Guihot, C, Fardeau, V, Touitoue, D, Saadoun, B, Bodaghi, P, Sève, and S, Trad
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Adult ,Uveitis ,Tuberculin Test ,Humans ,Prospective Studies ,Tuberculosis, Ocular ,Middle Aged ,Interferon-gamma Release Tests ,Scleritis - Abstract
Ocular tuberculosis (TB) diagnosisremains difficult and quantiferon (QFT) contribution needs still yet to be specified, despite its generalization in France. The purpose of this observational study is to assess in which ocular inflammation (OI) presentation QFT is prescribed and to evaluate the added value of new QuantiFERON®-TB Gold Plus (QFT-Plus) test for diagnosis ocular TB diagnosis.Monocentric, observational study, carried out in an ophthalmology department over a period of 5 months. Inclusion criteria were defined as an existence of an OI for which a QFT-Plus test was part of the etiological investigations. Of the 316 consecutive files, 72 were excluded (indeterminate test, prescription before anti-TNFα or immunosuppressant initiation, missing data, wrong indication) and 244 were selected and divided into two groups: group one (anterior uveitis/episcleritis, n=129) and group two (intermediate/posterior uveitis/optic neuritis/ocular myositis, n=115). All positive QFT patients underwent an etiological investigation including thoracic imaging.Forty-five patients, aged 52±12 years, had positive QFT (18.5%), including 18 patients for group 1 and 27 for group 2. Living in TB-endemic area, TB exposure and chest imaging abnormalities were identified in 70%, 27% and 22% of cases, respectively. OI was chronic in 36% of cases (group one, 4/18; group two, 12/27). None of the 18 patients, in group 1, received anti-tuberculosis treatment (ATT) or experienced a relapse during one-year follow-up. Four QFT+ patients, from group 2 (15%) had another associated disease explaining their uveitis. Among the 23 other patients without identified etiology, 13 had at least one relevant ophthalmological signs predictive of TB uveitis (posterior synechiae, retinal vasculitis and/or choroidal granuloma) (59%). Eleven patients received a 6-month ATT trial. Radiological abnormalities and granulomas at angiography were significantly more frequent among treated patients (p=0.03 and 0.001, respectively). A full OI recovery was observed for 8 patients (73%), considered ex-post as ocular TB. Nine patients in group 2 received rifampicin/isoniazid dual therapy for 3 months, but no conclusion could be drawn as to the benefit of such prescription on OI. QFT rate comparison, according to CD4 stimulation by ESAT-6/CFP-10 peptides or by CD4/CD8 co-stimulation, was comparable and found only 4 cases of discrepancy (1.6%). None of these 4 cases had ocular TB diagnosis.Positive QFT frequency among patients consulting for posterior OI remains high. In this study, radiological abnormalities and granulomas at angiography seemed to be more closely related to clinician decision for starting ATT trial in QFT+ patients, which was effective in 73% of cases. QFT-Plus does not seem more relevant than QFT-TB in exploring an OI. Prospective studies are necessary to codify QFT management in the etiological assessment of OI and clearly define ATT trial indications as well as their modalities.
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- 2020
68. [Spontaneous adrenal hematomas. Retrospective analysis of 20 cases from a tertiary center]
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N, Senni, M, Gerfaud-Valentin, A, Hot, C, Huissoud, P, Gaucherand, J, Tebib, C, Broussolle, Y, Jamilloux, and P, Sève
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Adult ,Hematoma ,Pregnancy ,Adrenal Gland Diseases ,Anticoagulants ,Humans ,Female ,Hemorrhage ,Antiphospholipid Syndrome ,Retrospective Studies - Abstract
Spontaneous adrenal hemorrhages (AH) are a rare condition with no consensus about their management.Patients were identified using the Medicalization of the Information System Program database, imaging software and a call for observations to internists, intensivists and obsetricians working at our institution. Adult patients whose medical records were complete and whose diagnosis was confirmed by medical imaging were included.From 2000 to 2007, 20 patients were identified, including 15 were women. The clinical onset of AH was non-specific. In five cases, AH occurred during pregnancy; four of them were unilateral and right sided. The etiology of the other fifteen (bilateral adrenal hemorrhage in 11) were as follows: antiphospholipid syndrome (n=8), heparin-induced thrombocytopenia (n=4), essential thrombocythemia (n=3), spontaneous AH due to oral anticoagulants (n=1), complication of a surgical act (n=3), and sepsis (n=3). In seven cases, two causes were concomitant. The diagnosis of AH was often confirmed by abdominal CT. An anticoagulant treatment was initiated in 16 cases. Ten of the eleven patients presenting with bilateral adrenal hematomas were treated using a long-term substitute opotherapy. One patient died because of a catastrophic antiphospholipid syndrome.The clinical onset of HS is heterogeneous and non-specific. The confirmatory diagnosis is often based on abdominal CT. The search for an underlying acquired thrombophilia is essential and we found in this study etiological data comparable to the main series in the literature. Adrenal insufficiency is most of the time definitive in cases of bilateral involvement.
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- 2020
69. Tuberculose oculaire
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S. Trad, D. Saadoun, M.H. Errera, S. Abad, P. Bielefeld, C. Terrada, D. Sène, B. Bodaghi, and P. Sève
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Gastroenterology ,Internal Medicine - Published
- 2018
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70. Effectiveness of colchicine in a case of recurrent compressive rheumatoid pericarditis
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Sève, Pascal, Stankovic, Katia, and Broussolle, Christiane
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- 2005
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71. COMPARISON OF PRIMARY AND SECONDARY FORMS OF MULTIPLE EVANESCENT WHITE DOT SYNDROME
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Serrar, Yasmine, Cahuzac, Armelle, Gascon, Pierre, Langlois-Jacques, Carole, MAUGET-FAŸSSE, Martine, Wolff, Benjamin, Sève, Pascal, Kodjikian, Laurent, and Mathis, Thibaud
- Abstract
This study reviewed 101 eyes with multiple evanescent white dot syndrome, including 60 primary and 41 secondary forms of multiple evanescent white dot syndrome triggered by an underlying pathology. Outer retinal lesions on late-phase indocyanine green angiography were less extensive and less symmetrical on the posterior pole in secondary forms of multiple evanescent white dot syndrome.
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- 2022
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72. Coexisting relapsing polychondritis and sarcoidosis: an unusual association
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Pasquet, Florian, Cottin, Vincent, Sivova, Nadia, Le Scanff, Julie, Broussolle, Christiane, and Sève, Pascal
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- 2010
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73. Campylobacter infection in adult patients with primary antibody deficiency
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Jérémie Dion, Marion Malphettes, Lucie Bénéjat, Francis Mégraud, Alain Wargnier, David Boutboul, Lionel Galicier, Vincent Le Moing, Patrick Giraud, Arnaud Jaccard, Raphaële Nove-Josserand, Claire Fieschi, Eric Oksenhendler, Laurence Gérard, E. Oksenhendler, C. Fieschi, M. Malphettes, L. Galicier, S. Georgin, J.P. Fermand, J.F. Viallard, A. Jaccard, C. Hoarau, Y. Lebranchu, A. Bérezné, L. Mouthon, M. Karmochkine, N. Schleinitz, I. Durieu, R. Nove-Josserand, V. Chanet, V. Le-Moing, N. Just, C. Salanoubat, R. Jaussaud, F. Suarez, O. Hermine, P. Solal-Celigny, E. Hachulla, G. Condette-Wojtasik, L. Sanhes, M. Gardembas, I. Pellier, P. Tisserant, M. Pavic, B. Bonnotte, J. Haroche, Z. Amoura, L. Alric, M.F. Thiercelin, L. Tetu, D. Adoue, P. Bordigoni, T. Perpoint, P. Sève, P. Rohrlich, J.L. Pasquali, P. Soulas-Sprauel, L.J. Couderc, P. Giraud, A. Baruchel, I. Deleveau, F. Chaix, J. Donadieu, F. Tron, C. Larroche, A.P. Blanc, A. Masseau, M. Hamidou, G. Gorochov, J.L. Garnier, H. Moins, L. Gérard, Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7), Recherche clinique appliquée à l'hématologie ((EA_3518)), Université Paris Diderot - Paris 7 (UPD7), Université de Bordeaux (UB), Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Recherche clinique appliquée à l'hématologie (URP_3518), Université de Paris (UP), Clinique Pont-de-Chaume, CHU Limoges, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), DEFI study group: E Oksenhendler, C Fieschi, M Malphettes, L Galicier, S Georgin, J P Fermand, J F Viallard, A Jaccard, C Hoarau, Y Lebranchu, A Bérezné, L Mouthon, M Karmochkine, N Schleinitz, I Durieu, R Nove-Josserand, V Chanet, V Le-Moing, N Just, C Salanoubat, R Jaussaud, F Suarez, O Hermine, P Solal-Celigny, E Hachulla, G Condette-Wojtasik, L Sanhes, M Gardembas, I Pellier, P Tisserant, M Pavic, B Bonnotte, J Haroche, Z Amoura, L Alric, M F Thiercelin, L Tetu, D Adoue, P Bordigoni, T Perpoint, P Sève, P Rohrlich, J L Pasquali, P Soulas-Sprauel, L J Couderc, P Giraud, A Baruchel, I Deleveau, F Chaix, J Donadieu, F Tron, C Larroche, A P Blanc, A Masseau, M Hamidou, G Gorochov, J L Garnier, H Moins, C Fieschi, M Malphettes, L Gérard, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)
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Adult ,Male ,medicine.medical_specialty ,Gastrointestinal Diseases ,[SDV]Life Sciences [q-bio] ,Primary Immunodeficiency Diseases ,Population ,medicine.disease_cause ,Antibodies ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal medicine ,Campylobacter Infections ,medicine ,Prevalence ,Immunology and Allergy ,Humans ,030212 general & internal medicine ,education ,ComputingMilieux_MISCELLANEOUS ,education.field_of_study ,Univariate analysis ,business.industry ,Campylobacter ,Liver Diseases ,Middle Aged ,medicine.disease ,Comorbidity ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,Diarrhea ,030228 respiratory system ,Bacteremia ,Coinfection ,Female ,France ,medicine.symptom ,business ,Complication ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Primary antibody deficiency (PAD) is characterized by a defective immunoglobulin production and recurrent infections, mostly involving respiratory and gastrointestinal tracts. Chronic or recurrent diarrhea is reported in up to 23%. Campylobacter infection is a common cause of infectious diarrhea, reported in 1.2% to 7.5% of patients with common variable immunodefi-ciency (CVID), the most frequent PAD. The aim of this study was to describe Campylobacter infection in patients with PAD included in a large nationwide study and analyze factors associ-ated with susceptibility to this pathogen. The DEFI (DEFicit Immunitaire) study is an ongoing large cross-sectional French multicentric study of adults with PAD, with retrospective collection of clinical data. All patients with a history of bacteriologically documented Campylobacter infection were identified, and clinical data were collected for each episode. Factors associated with recurrent infection were assessed as oddsratio (OR) and 95% confidence interval (CI), calculated by means of simple regression analysis. In patients with available material, strains of each episode were characterized using molecular analysis and compared (Table E1, available in this article’s Online Repository at www.jaci-inpractice.org). A com-parison of immunodeficiency-related characteristics of patients with and without Campylobacter infection was performed in the homogeneous group of patients with CVID. The control group included patients with CVID from DEFI centers who confirmed that patients did not develop Campylobacter infection after enrollment (Figure E1, available in this article’s Online Repository at www.jaci-inpractice.org). After correction for multiple comparisons, P
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- 2018
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74. Successful treatment with rituximab in a patient with mental nerve neuropathy in primary Sjögren’s syndrome
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Sève, Pascal, Gachon, Emilie, Petiot, Philippe, Stankovic, Katia, Charhon, Annick, and Broussolle, Christiane
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- 2007
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75. [JAK inhibitors: Perspectives in internal medicine]
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T, El Jammal, M, Gerfaud-Valentin, P, Sève, and Y, Jamilloux
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Arthritis, Rheumatoid ,Internal Medicine ,Humans ,Janus Kinase Inhibitors ,Psoriasis ,Colitis, Ulcerative ,Protein Kinase Inhibitors ,Autoimmune Diseases - Abstract
In the past ten years, the better understanding of the pathophysiological mechanisms underlying inflammatory and autoimmune diseases has led to the emergence of many targeted therapies. Among them, the Janus kinase inhibitors are acting upstream in the inflammatory cascade of several key cytokines in disorders such as rheumatoid arthritis, ulcerative colitis or psoriasis. At the moment, these three diseases represent the only indications validated by the FDA and the EMA of the use of JAK inhibitors apart from hematology. Preclinical data and therapeutic trials indicate their efficacy in other autoimmune or inflammatory conditions, such as lupus, dermatomyositis, ankylosing spondylitis, sarcoidosis and giant cell arteritis. This review provides a summary of current use and advancement of knowledge in the use of JAK inhibitors in pathologies faced by internists.
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- 2019
76. [It is time to reconcile systemic juvenile idiopathic arthritis and adult-onset Still's disease]
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Y, Jamilloux, S, Georgin-Lavialle, P, Sève, A, Belot, and B, Fautrel
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Adult ,Male ,Interleukin-6 ,Age Factors ,Arthritis, Juvenile ,Systemic Inflammatory Response Syndrome ,Phenotype ,Sex Factors ,Humans ,Female ,Age of Onset ,Symptom Assessment ,Child ,Still's Disease, Adult-Onset ,Interleukin-1 - Published
- 2019
77. Diatom bloom in the tidal freshwater zone of a turbid and shallow estuary, Rupert Bay (James Bay, Canada)
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De Sève, M. A.
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- 1993
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78. Flavor and TASTE attributes and nutritional insights of maize tortillas from landraces of Mexican races
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Y. Salinas-Moreno, A. Gálvez-Mariscal, P. Severiano-Pérez, G. Vázquez-Carrillo, and L.L. Trejo-Téllez
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Zea mays L. ,Artisanal tortillas ,Sensorial attributes ,Mineral composition ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Maize tortilla is the best-recognized food product of Mexican gastronomy. Artisanal maize tortillas (AMT) are prepared with native maize varieties and a traditional process. The aims of this study were to identify sensory attributes, texture, and color in AMT that allow them to be differentiated from commercial tortillas, and to determine the chemical and mineral composition of both types of tortillas. Six landraces related to four Mexican maize races were used. Two commercial tortillas were included as references (tortillería and supermarket). Tortillas were subjected to sensory analysis by the modified Flash technique, texture and color were measured objectively and chemical and mineral analysis of all tortillas were evaluated. Lime taste and lime smell attributes were relevant to differentiate AMT from commercial tortillas; aftertaste and fracturability attributes were highly associated to supermarket tortillas. The fracturability attribute of tortillas is consider undesirable for taco preparation. Five of the six AMT were characterized by the presence of a layer, a characteristic that is associated with traditional tortilla made by Mexican consumer. Regarding chemical composition, supermarket tortillas exhibited the highest dietary fiber content (17.09%), but showed 30% more Na than AMT, with the exception of tortillas from Purepecha native variety. Besides, supermarket tortilla had 48.9% less Ca than AMT. The sensory attributes relevant to differentiate native maize tortillas from the commercial maize tortilla references were appearance, smell, and taste, while textural and color attributes played a lesser role.
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- 2024
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79. Uvéites : que doivent savoir le rhumatologue et l'interniste ?
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Sève, Pascal, Kodjikian, Laurent, Bert, Arthur, and Jammal, Thomas El
- Abstract
Le rhumatologue et l'interniste peuvent être sollicités tant pour le diagnostic étiologique que pour la prise en charge thérapeutique d'une uvéite. L'étude prospective ULISSE (Uvéites: évaluation clinique et médico-économique d'une stratégie standardisée pour le diagnostic étiologique) a montré l'intérêt d'une stratégie diagnostique orientée selon le type anatomo-clinique de l'uvéite. Une analyse secondaire a montré qu'une faible proportion d'examens était utile au diagnostic. Ces examens sont peu coûteux, simples et guidés par les données cliniques. Les uvéites des spondyloarthrites suivent une « règle des 90 » : 90 % d'entre elles sont unilatérales, aiguës et antérieures. Environ 2/3 des spondyloarthrites sont diagnostiquées au moment de l'uvéite. L'existence de douleurs rachidiennes d'allure inflammatoire ou non doit faire rechercher une spondyloarthrite qui représente la première cause d'uvéite dans les pays occidentaux. Le risque de cécité est exceptionnel; la problématique est celle des récurrences (50 à 60 %). La sulfasalazine diminue la fréquence, la durée et l'intensité des uvéites et peut être proposée à titre préventif. La sarcoïdose est une cause sous-estimée d'uvéites (jusqu'à 15 %), notamment chez les femmes d'âge mûr. Le traitement des uvéites sarcoïdosiques s'apparente à celui des uvéites idiopathiques. Les uvéites de la maladie de Behçet affectent des individus jeunes, des deux sexes, de toute origine et se présentent habituellement comme une panuvéite et une vascularite rétinienne. Le traitement des uvéites associées à la maladie de Behçet a pour objectif l'obtention d'un calme oculaire total. Le pronostic des formes sévères et réfractaires a été transformé par les anticorps monoclonaux anti-TNF-α. Rheumatologists and internists may need to establish the etiological diagnosis and handle the therapeutic management of adults with uveitis. A prospective study named ULISSE (Uveitis: clinical and medicoeconomic evaluation of a standardized strategy for etiological diagnosis) has shown that a standardized strategy for the etiological diagnosis of uveitis was neither inferior nor superior to an open strategy. Subsequent analysis showed that only a few diagnostic tests were useful for the etiological assessment of uveitis. These tests were often inexpensive, simple, usually guided by clinical findings, and allowed an etiological diagnosis to be made for many patients. Three systemic diseases are particularly prevalent in patients referred to internists or rheumatologists: HLA-B27- and spondyloarthritis-associated uveitis, Behçet's disease, and sarcoidosis. Uveitis associated with spondyloarthritis follows a « rule of 90 »: around 90 of cases are unilateral, anterior, and acute. Among patients with uveitis and spondyloarthritis, about two thirds are diagnosed with joint disease during a uveitis assessment. Patients with inflammatory or noninflammatory low back pain should be routinely evaluated for spondyloarthritis, which is the leading cause of uveitis in western countries. The risk of blindness is extremely low, and the main complication is recurrent uveitis, seen in 50 to 60 % of cases. Sulfasalazine decreases the frequency, duration, and severity of uveitis and can be used prophylactically. Sarcoidosis is an underestimated cause of uveitis, which occurs in 15 % of cases, with a predilection for middle-aged women. The treatment of sarcoid uveitis largely follows the general principles of idiopathic uveitis. Behçet's disease uveitis affects young people of both sexes and of all origins and usually presents as panuveitis and retinal vasculitis. The treatment of Behçet's uveitis aims at a complete disappearance of the ocular inflammation. The prognosis of the severe and refractory forms has been dramatically changed by the introduction of TNF-α antagonists. [ABSTRACT FROM AUTHOR]
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- 2021
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80. Class III β-tubulin is a marker of paclitaxel resistance in carcinomas of unknown primary site
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Sève, Pascal, Reiman, Tony, Lai, Raymond, Hanson, John, Santos, Cheryl, Johnson, Lorelei, Dabbagh, Laith, Sawyer, Michael, Dumontet, Charles, and Mackey, John R.
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- 2007
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81. Efficacité du tocilizumab dans la prise en charge de l’œdème maculaire cystoïde et des vascularites rétiniennes au cours des uvéites non-infectieuses : étude multicentrique BIOVAS
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M. Leclercq, G. Maalouf, P. Sève, P. Bielefeld, B. Rouviere, N. Girszyn, T. Moulinet, J. Gueudry, T. Sené, D. Sene, P. Cacoub, F. Domont, A.C. Desbois, T. Sarah, B. Bodaghi, L. Biard, and D. Saadoun
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Gastroenterology ,Internal Medicine - Published
- 2020
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82. [Ocular tuberculosis]
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S, Trad, D, Saadoun, M H, Errera, S, Abad, P, Bielefeld, C, Terrada, D, Sène, B, Bodaghi, and P, Sève
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Diagnosis, Differential ,Tuberculin Test ,Prevalence ,Humans ,Mycobacterium tuberculosis ,Tuberculosis, Ocular - Abstract
Despite extensive investigations, including the use of Interferon-gamma release assays (IGRA), the diagnosis of intraocular tuberculosis (TB) remains challenging. Ocular evidence of Mycobacterium tuberculosis in low endemic countries for TB is extremely rare, leading mostly to a TB-related ocular inflammation presumptive diagnosis. This present work aims: to highlights the main clinical patterns suggestive of ocular TB; and the latest recommended guidelines for diagnosing ocular TB to clarify interferon-gamma release assay (IGRA) contribution and accuracy to the management of intraocular TB and its diagnosis, in addition to other available diagnostic tools, such as tuberculin skin test, bacteriologic and histologic analysis from intra/extra ocular sample and radiographic investigations; to define the accuracy of these diagnostic tools according to the endemic TB prevalence; and finally to identify therapeutic strategies adapted to the main clinical presentations of ocular TB. Our review of the literature shows that management of suspected ocular TB differs significantly based on whether patients are from high or low TB prevalence countries since accuracy of chest X-ray, tuberculin skin test and IGRA is significantly different. Taking into account these discrepancies, distinct guidelines should be determined for managing patients with suspected ocular TB, taking into consideration home prevalence of TB-patients.
- Published
- 2018
83. Thromboses de la veine cave inférieure : une étude rétrospective cas contrôle de 165 patients
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M. Verkimpe, L. Bertoletti, S. Jardel, M. Giraud, F. Gay, A. Hot, P. Sève, P. Rousset, and J.C. Lega
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Gastroenterology ,Internal Medicine - Abstract
Introduction Parmi les manifestations de la maladie thromboembolique veineuse (MTEV), entite regroupant thrombose veineuse proximale et embolie pulmonaire, on observe une thrombose de la veine cave inferieure (TVCI) dans 4 a 15 % des cas. C’est une localisation peu frequente et il existe a ce jour peu de series publiees sur le sujet. Le but de notre etude concernant la TVCI est de decrire les caracteristiques cliniques des patients, les caracteristiques de la maladie (etiologie, pronostic) et les traitements utilises. Materiels et methodes Nous avons realise une etude observationnelle, retrospective, bicentrique, controlee sur 2 centres hospitalo-universitaires francais entre mars 2010 et novembre 2017. Nous avons recueilli les donnees des patients atteints de TVCI (groupe TVCI issus des deux CHU) et les avons compares avec les donnees des patients atteints de maladie thromboembolique veineuse sans TVCI (groupe controle issu d’un seul CHU). Les donnees ont ete recueillies via le dossier patient informatise. Resultats 165 cas de patients porteurs de TVCI ont ete identifies (âge median 62 ans, 43 % de femmes) pour 727 patients atteints de maladie thromboembolique veineuse hors TVCI (âge median 69 ans, 54 % de femmes). La frequence de TVCI etait de 11 %. Les patients du groupe TVCI presentaient une embolie pulmonaire concomitante dans 35 % des cas. Il existait une pathologie associee a la thrombose chez 139 patients (84 %). Les principales causes de thromboses dans notre cohorte etaient l’existence d’une pathologie abdominale sous-jacente (71 %) et l’existence d’une neoplasie associee (62 %). La neoplasie n’etait presente que chez 140 patients soit 20 % du groupe controle (p Conclusion Cette cohorte de grande taille permet de preciser les determinants de la TVCI dans le spectre de la MTEV. La cause la plus frequente de thrombose de la veine cave inferieure est l’existence d’une neoplasie, principalement abdominale. A contrario, la place pour la recherche de syndrome des anticorps anti-phospholipides ou de thrombophilie acquise est limitee. La mortalite est plus importante en TVCI, probablement du fait de la neoplasie sous-jacente.
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- 2019
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84. Réponses aux items des questionnaires spécifiques de qualité de vie dans les 18 mois suivant une poussée de lupus érythémateux systémique : une analyse en théorie de la réponse à l’item de la cohorte française EQUAL
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Laurent Arnaud, N. Magy-Bertrand, P. Sève, Marie Corneloup, Thierry Martin, François Maurier, O. Aumaître, A. Bourredjem, S. Berthier, G. Muller, Zahir Amoura, Jean-Loup Pennaforte, Hervé Devilliers, Denis Wahl, and G. Blaison
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Etat de la question Le lupus erythemateux systemique (LES) est une maladie auto-immune rare impactant lourdement la qualite de vie (QdV) des patients. La plupart des etudes longitudinales precedentes portaient sur des questionnaires generiques et ne detaillaient pas l’influence du type de poussee clinique sur l’evolution de la QDV. Notre etude avait pour objectif d’evaluer l’evolution de la qualite de vie specifique dans les 18 mois suivant une poussee clinique, a l’aide d’une approche basee sur la theorie de reponse aux items. Materiel et methodes La cohorte prospective longitudinale francaise EQUAL est constituee de patients atteints de LES suivis pendant deux ans. La QDV specifique selon le LupusQol et le SLEQOL a ete recueillie tous les trois mois. L’activite lupique selon le SELENA-SLEDAI (SFI) et le SELENA-SLEDAI revise (SFI-R) a ete evaluee tous les six mois. La reponse aux items des questionnaires specifiques LupusQoL et SLEQOL par des patients dans les 18 mois (a 6, 12 et 18 mois apres une poussee) suivant une poussee clinique a ete comparee a celle des patients sans poussee grâce a un modele lineaire logistique a hypotheses assouplies pour les dimensions de chaque questionnaire. Resultats Entre decembre 2011 et juillet 2015, 336 patients ont ete inclus (89,9 % de femmes). Les domaines du LupusQol et du SLEQOL concernant la qualite de vie physique (sante physique, fonctionnement physique et douleur) etaient les plus impactes par les poussees osteoarticulaires et cutanees (perte d’independance, ralentissement moteur, difficulte a la marche, impact de la douleur sur les activites, le sommeil, la mobilite, inquietude lie a la douleur articulaire, sentiment de gene pour les autres et de tristesse). Les items impactes par la poussee cutanee concernaient egalement les problematiques d’image de soi. Les poussees neurologiques ou psychiatriques impactaient plus severement la qualite de vie specifique. La qualite de vie des patients est modifiee jusqu’a 18 mois apres une poussee. Conclusion Les resultats d’analyse selon la theorie de reponse aux items permettent de reperer les items qui representent le mieux l’evolution de la qualite de vie des patients. Les items portant sur la sante physique et sur la douleur sont les plus sensibles aux variations de QDV apres une poussee osteoarticulaire ou cutanee, indiquant que cette preoccupation des patients s’ameliore dans les six a 18 mois apres une poussee.
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- 2019
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85. Prognostic Factors and Treatment Efficacy in Spinal Cord Sarcoidosis
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Gavoille, Antoine, Desbois, Anne-Claire, Joubert, Bastien, Durel, Cécile-Audrey, Auvens, Clément, Berthoux, Emilie, Delboy, Thierry, Dufour, Jean François, Turcu, Alin, Bonnotte, Bernard, Moreau, Thibault, Le Guenno, Guillaume, André, Marc, Ruivard, Marc, Camdessanche, Jean-Philippe, Antoine, Jean-Christophe G., Marignier, Romain, Chapelon-Abric, Catherine, Saadoun, David, and Sève, Pascal
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- 2022
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86. Automatic weighting filter tuning for robust flight control law design
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Pérez, Carlos Alcolea, Theodoulis, Spilios, Sève, Florian, and Goerig, Laurent
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This article presents a practical framework for the co-design of weighting filter parameters and controller gains in the context of multi-objective/multi-model tuning of flight control laws. A non-smooth optimization-based procedure is proposed aiming to reduce the complexity of the control design process, evolving from a rather classical manual filter selection all the way to a fully automatic one. A normal acceleration Control Augmentation System (CAS), designed by making use of non-smooth optimization software, for the linearized dynamics of an agile autonomous aerospace vehicle is used as an illustrative example. Several performance indexes are compared in the context of the developed framework as well as against more classical tuning methods such as pole placement, demonstrating that the proposed approach may lead to improved results and potentially benefit the flight control engineer via an easier handling of conflicting design requirements, model uncertainty and application-tailored control structures.
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- 2022
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87. Observance pour l'immunothérapie allergénique sublinguale et stratégies pour l'améliorer.
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Sève, E., Trinh, H.B., Pouliquen, M., Cottet, J., Fromentin, E., Lefevre, S., Fontaine, J.F., and Demoly, P.
- Abstract
L'immunothérapie allergénique est le seul traitement étiologique des allergies. La forme sublinguale est un traitement à prendre quotidiennement au minimum pendant 3 ans. L'observance des patients est un problème majeur car seulement 15 % des patients terminent les 3 ans. Afin d'améliorer cette problématique, il faut en identifier les causes (financières, effets secondaires, absence d'amélioration clinique, mauvaise compréhension du traitement ou lassitude) pour proposer au patient une solution adaptée (suivi personnalisé, encouragements, informations régulières). Les moyens technologiques modernes comme la télémédecine, les applications mobiles, les réseaux sociaux sont également des outils au service de l'allergologue pour accompagner le patient dans sa prise en charge. Allergen immunotherapy is the only etiological treatment for allergies. The sublingual form is a long treatment, to be taken daily for at least 3 years. Patient adherence is a major problem as only 15% of patients maintain it for 3 years. To improve this, it is necessary to find the causes (financial, side effects, lack of clinical improvement, poor understanding of the treatment or forgetfulness) to give to the patient a suitable solution (personalized follow-up, support, available information). Modern technological means such as telemedicine, mobile applications, social networks are also tools for the allergist to help the patient to continue his allergen immunotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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88. [Therapeutic strategy for the treatment of non-infectious uveitis proposed by an expert panel]
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E, Diwo, P, Sève, S, Trad, P, Bielefeld, D, Sène, S, Abad, A, Brézin, P, Quartier, I, Koné Paut, M, Weber, C, Chiquet, M H, Errera, J, Sellam, P, Cacoub, G, Kaplanski, L, Kodjikian, B, Bodaghi, and D, Saadoun
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Biological Therapy ,Uveitis ,Biological Products ,Adrenal Cortex Hormones ,Tumor Necrosis Factor-alpha ,Practice Guidelines as Topic ,Antibodies, Monoclonal ,Humans ,Expert Testimony ,Immunosuppressive Agents - Abstract
Conventional immunosuppressive drugs, anti-TNF alpha and other biotherapies used in clinical practice are capable of controlling non-infectious anterior uveitis, posterior uveitis and panuveitis. The present work has been led by a multidisciplinary panel of experts, internists, rheumatologists and ophthalmologists and is based on a review of the literature. In case of corticodependency or sight-threatening disease, conventional immunosuppressive drugs (methotrexate, azathioprine and mycophenolate mofetil) and/or anti-TNF alpha (adalimumab, infliximab) are used to achieve and maintain remission. Interferon is an efficient immunomodulatory treatment, as a second-line therapy, for some therapeutic indications (refractory macular edema, Behçet's vascularitis). Other biologics, especially tocilizumab, are showing promising results. Local treatments (corticosteroids, sirolimus etc.) are adjuvant therapies in case of unilateral inflammatory relapse. Therapeutic response must be evaluated precisely by clinical examination and repeated complementary investigations (laser flare photometry, multimodal imaging, perimetry, electroretinography measures).
- Published
- 2018
89. [Management of orbital inflammation in internal medicine. Proposal for a diagnostic work-up]
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S, Abad, F, Héran, C, Terrada, P, Bielefeld, D, Sène, S, Trad, D, Saadoun, and P, Sève
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Diagnosis, Differential ,Inflammation ,Health Knowledge, Attitudes, Practice ,Physicians ,Internal Medicine ,Orbital Diseases ,Humans ,Diagnostic Techniques, Ophthalmological ,Algorithms - Abstract
Inflammatory orbitopathies relate to an inflammatory state originating within the orbit and its adnexes, except the inner ocular globe. Orbital inflammation (OI) may be either localized manifestation of a proven or like autoimmune disease, or local response from immune system against infectious, structural or tumoral antigens. We review the clinical manifestations of OI, which provide helpful clues to the diagnosis and describe the inflammatory, infectious and neoplastic conditions classically associated with OI. Autoimmune diseases are probably the most common causes of OI associated with a bilateral dacryoadenitis (e.g., sarcoidosis, granulomatosis with polyangiitis, IgG4-related disease). We focused on a major part of the IgG4-RD spectrum, the IgG4-related orbital disease which has been recently described and the idiopathic orbital inflammation syndrome that one should consider in patients 40 years of age or older with non specific inflammation OI on biopsy but without underlying local or systemic disease. An algorithm for the diagnostic approach of OI was proposed. If systemic explorations fail to diagnose an underlying disease, histopathologic control is required for distinguishing non-specific OI from other differential diagnosis, especially lymphoma. In the cases of pure myositic locations and posteriorly located tumours where biopsy could damage to the optic nerve, analysis of orbital lesions in T2W IRM sequence may be helpful to distinguish idiopathic OI (IOI) from lymphoma. When the diagnostic work-up fails, a corticosteroid trial could be used, but its beneficial effect has to be cautiously interpretated before definitively diagnosing IOI. Finally, treatments used in main infllammatory orbitopathies were also reviewed.
- Published
- 2017
90. [Scleritis and systemic diseases: What should know the internist?]
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P, Bielefeld, D, Saadoun, E, Héron, S, Abad, H, Devilliers, C, Deschasse, S, Trad, D, Sène, G, Kaplanski, and P, Sève
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Inflammation ,Vasculitis ,Health Knowledge, Attitudes, Practice ,Physicians ,Internal Medicine ,Humans ,Diagnostic Techniques, Ophthalmological ,Autoimmune Diseases ,Scleritis - Abstract
Scleritis is an inflammatory disease of the sclera; outer tunic of the eye on which the oculomotor muscles are inserted. It can be associated with a systemic disease up to one time out of 3. These associated diseases are mainly rheumatoid arthritis, vasculitis, including granulomatosis with polyangiitis in the first line and spondyloarthropathies. Before mentioning such an etiology, it is necessary to eliminate an infectious cause, mainly herpetic, which is regularly underestimated. The classification of scleritis is clinical. We distinguish between anterior scleritis and posterior scleritis. Anterior scleritis is diffuse or nodular, usually of good prognosis. Anterior necrotizing scleritis with inflammation is often associated with an autoimmune disease, necrotizing scleritis without inflammation usually reflects advanced rheumatoid arthritis. The treatment of these conditions requires close collaboration between internists and ophthalmologists to decide on the use of corticosteroid therapy with or without immunosuppressors or biotherapies.
- Published
- 2017
91. [Ocular sarcoidosis: What the internist should know?]
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P, Sève, L, Kodjikian, and Y, Jamilloux
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Aged, 80 and over ,Male ,Uveitis ,Health Knowledge, Attitudes, Practice ,Sarcoidosis ,Physicians ,Age Factors ,Ethnicity ,Internal Medicine ,Vision Disorders ,Humans ,Female ,Algorithms - Abstract
Sarcoidosis is one of the leading causes of inflammatory eye disease. Any part of the eye and its adnexal tissues can be involved. Uveitis and optic neuropathy are the main manifestations, which the internists face. This review reports the state of knowledge for these two ocular involvements and proposes an assessment-algorithm for sarcoidosis in patients with suspected sarcoid uveitis. Two groups of patients with sarcoid uveitis can be distinguished: one young and multiethnic group in which ophthalmological findings are various and another group of elderly Caucasian women with mostly chronic posterior uveitis. Clinically isolated uveitis revealing sarcoidosis remains a strictly ocular condition in a large majority of cases. Although it could be a serious condition involving functional prognosis, an early recognition in addition to a growing therapeutic arsenal including intravitreal implant seems to have improved visual prognosis of the disease in the last years. Systemic corticosteroids are indicated when uveitis does not respond to topical corticosteroids or when there is bilateral posterior involvement, especially macular edema and occlusive vasculitis. In up to 25% of cases that require an unacceptable dosage of corticosteroids to maintain remission, additional immunosuppression is used, including methotrexate, azathioprine, and mycophenolate mofetil. Regarding systemic sarcoidosis, infliximab and adalimumab have been successfully used for the treatment of refractory or sight-threatening disease. Optic neuropathy often affects women of African and Caribbean origin. Some authors recommend that patients be treated with high-dose corticosteroids and concurrent immunosuppression from the onset for this manifestation, which may be associated with a poorer outcome.
- Published
- 2017
92. [Uveitis: Diagnostic work-up. Recommendations from an expert committee]
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P, Sève, B, Bodaghi, S, Trad, J, Sellam, D, Bellocq, P, Bielefeld, D, Sène, G, Kaplanski, D, Monnet, A, Brézin, M, Weber, D, Saadoun, P, Cacoub, C, Chiquet, and L, Kodjikian
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Adult ,Uveitis ,Practice Guidelines as Topic ,Humans ,Mass Screening ,Diagnostic Techniques, Ophthalmological ,Child ,Expert Testimony - Abstract
Diagnostic work-up of uveitis involves many uncertainties. Search for an etiology should take into account the epidemiology of uveitis and focus on the most severe diseases or those, which can be treated. This work was undertaken to establish recommendations for the diagnosis work-up of uveitis.Recommendations were developed by a multidisciplinary panel of 15 experts, including internists, ophthalmologists and a rheumatologist and are based on a review of the literature with regard to effectiveness of investigations and the results of the ULISSE study, which is the first prospective study assessing the efficiency of a standardized strategy for the etiological diagnosis of uveitis. Children, immunocompromised patients, severe retinal vasculitis and specific ophthalmological entities are excluded from these recommendations.Investigations should be first guided by the history and physical examination. Serological screening for syphilis is the only test appropriate in all forms of uveitis. If no diagnosis is made after this stage, we propose investigations guided by the anatomic characteristics of uveitis. It includes HLA B27 testing (in unilateral acute anterior non-granulomatous uveitis), serum angiotensin converting enzyme, interferon-gamma release assay and chest CT (chronic uveitis), cerebral MRI and anterior chamber tap with IL10 analysis (intermediate or posterior uveitis in patients over 40 years). Investigations ordered in the absence of orientation are almost always unhelpful.We propose a strategy for the etiologic diagnosis of uveitis. The recommendations should be updated regularly. The efficiency of more invasive investigations has yet to be evaluated.
- Published
- 2017
93. [Impact of the 2009 Afssaps guidelines on the management of venous thromboembolic disease in emergency department: Before/after study]
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L, De Massari, Y, Jamilloux, J-C, Lega, A, Sigal, X, Jacob, K, Tazarourte, K, Mensah, and P, Sève
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Male ,Emergency Medical Services ,Venous Thromboembolism ,Middle Aged ,Practice Guidelines as Topic ,Humans ,Female ,France ,Guideline Adherence ,Patient Safety ,Emergency Service, Hospital ,Public Health Administration ,Societies, Medical ,Aged ,Retrospective Studies - Abstract
The French Agency for Health Safety of Products published recommendations of good practices (RGP) for the treatment of venous thromboembolic disease in 2009. Four of these recommendations apply to the initial management of the disease, with the objective of this study is to determine whether the development and diffusion of the four RGP has had an impact on the practice.A retrospective before/after study comparing 132 patients treated in emergency department of the Civil Hospices of Lyon for pulmonary embolism (PE) and/or deep venous thrombosis (DVT) in 2008-2009 ("before") and 153 patients in 2010-2011 ("after").In the "before" period, 70 patients were treated for DVT and 62 patients for PE. In the "after" period, 50 patients were treated for DVT and 103 patients for PE. The compliance rate was not significantly different for the two periods for each RGP except for the indication of low molecular weight Heparin (LMWH) or fondaparinux in the absence of severe renal failure (21% "before" vs. 45% "after"; P=0.02) for patients with PE. Management for the four recommendations was conform for 5.6% of eligible patients in the "before" period and for 3.7% for the "after" period.Our study shows that globally there is no impact of RGP. The reasons appear multiple with first, the mere dissemination and the absence of implementation of these guidelines.
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- 2017
94. [Thymoma and autoimmune diseases]
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Y, Jamilloux, H, Frih, C, Bernard, C, Broussolle, P, Petiot, N, Girard, P, Sève, Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)
- Subjects
therapy ,Thymoma ,Patients ,Incidence ,T-Lymphocytes ,Autoimmunity ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Thymus Neoplasms ,Syndrome ,Skin Diseases ,Time ,Hepatitis ,Autoimmune Diseases ,surgery ,Risk Factors ,immune system diseases ,hemic and lymphatic diseases ,Immune System ,Humans ,Lymphocytes ,France ,Infection ,Skin - Abstract
International audience; The association between thymoma and autoimmunity is well known. Besides myasthenia gravis, which is found in 15 to 20% of patients with thymoma, other autoimmune diseases have been reported: erythroblastopenia, systemic lupus erythematosus, inflammatory myopathies, thyroid disorders, Isaac's syndrome or Good's syndrome. More anecdotally, Morvan's syndrome, limbic encephalitis, other autoimmune cytopenias, autoimmune hepatitis, and bullous skin diseases (pemphigus, lichen) have been reported. Autoimmune diseases occur most often before thymectomy, but they can be discovered at the time of surgery or later. Two situations require the systematic investigation of a thymoma: the occurrence of myasthenia gravis or autoimmune erythroblastopenia. Nevertheless, the late onset of systemic lupus erythematosus or the association of several autoimmune manifestations should lead to look for a thymoma. Neither the characteristics of the patients nor the pathological data can predict the occurrence of an autoimmune disease after thymectomy. Thus, thymectomy usefulness in the course of the autoimmune disease, except myasthenia gravis, has not been demonstrated. This seems to indicate the preponderant role of self-reactive T lymphocytes distributed in the peripheral immune system prior to surgery. Given the high infectious morbidity in patients with thymoma, immunoglobulin replacement therapy should be considered in patients with hypogammaglobulinemia who receive immunosuppressive therapy, even in the absence of prior infection
- Published
- 2017
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95. Cricoarytenoid arthritis in Sjögren’s syndrome
- Author
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Sève, Pascal, Poupart, Marc, Bui-Xuan, Cécile, Charhon, Annick, and Broussolle, Christiane
- Published
- 2005
- Full Text
- View/download PDF
96. A construção conjunta de um observatório e de um objeto teórico : o exemplo do relato da experiência e do espaço de ação.
- Author
-
Terré, Nicolas, Sève, Carole, and Huet, Benoît
- Abstract
Copyright of Laboreal is the property of Laboreal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
97. Investigation of a family outbreak of COVID-19 using systematic rapid diagnostic tests raises new questions about transmission.
- Author
-
Prazuck, Thierry, Giaché, Susanna, Gubavu, Camelia, Colin, Mathilda, Rzepecki, Vincent, Sève, Aymeric, Pialoux, Gilles, and Hocqueloux, Laurent
- Subjects
VIRAL pneumonia ,COVID-19 ,RAPID diagnostic tests ,EPIDEMICS ,SARS disease - Published
- 2020
- Full Text
- View/download PDF
98. Les trois niveaux de soin en allergologie.
- Author
-
Palussière, C. and Sève, E.
- Published
- 2024
- Full Text
- View/download PDF
99. Il y a 50 ans ... la découverte d’Aï Khanoum : 1964-1978, fouilles de la Délégation archéologique française en Afghanistan (DAFA)
- Author
-
Francfort, Henri-Paul, Grenet, Frantz, Lecuyot, Guy, Lyonnet, Bertille, Sève, Laurianne Martinez, Rapin, Claude, Francfort, Henri-Paul, Grenet, Frantz, Lecuyot, Guy, Lyonnet, Bertille, Sève, Laurianne Martinez, and Rapin, Claude
- Published
- 2014
100. [Recurrent pericarditis: What is new in 2017?]
- Author
-
Y, Jamilloux, M, Gerfaud-Valentin, and P, Sève
- Published
- 2017
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