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51. The CAT Imaging Telescope for Very-High-Energy Gamma-Ray Astronomy

Author: Barrau, A., Bazer-Bachi, R., Beyer, E., Cabot, H., Cerutti, M., Chounet, L. M., Debiais, G., Degrange, B., Delchini, H., Denance, J. P., Descotes, G., Dezalay, J. P., Djannati-Atai, A., Dumora, D., Espigat, P., Fabre, B., Fleury, P., Fontaine, G., George, R., Ghesquiere, C., Gilly, J., Goret, P., Gouiffes, C., Gouillaud, J. C., Gregory, C., Grenier, I. A., Iacoucci, L., Kalt, L., Bohec, S. Le, Malet, I., Meynadier, C., Mols, J. P., de Freitas, P. Mora, Morano, R., Morinaud, G., Munz, F., Palatka, M., Palfrey, T. A., Pare, E., Pons, Y., Punch, M., Quebert, J., Ragan, K., Renault, C., Rivoal, M., Rob, L., Schovanek, P., Smith, D., Tabary, A., Tavernet, J. P., Toussenel, F., and Vrana, J.
Subjects: Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: The CAT (Cherenkov Array at Themis) imaging telescope, equipped with a very-high-definition camera (546 fast phototubes with 0.12 degrees spacing surrounded by 54 larger tubes in two guard rings) started operation in Autumn 1996 on the site of the former solar plant Themis (France). Using the atmospheric Cherenkov technique, it detects and identifies very high energy gamma-rays in the range 250 GeV to a few tens of TeV. The instrument, which has detected three sources (Crab nebula, Mrk 421 and Mrk 501), is described in detail., Comment: 24 pages, 15 figures. submitted to Elsevier Preprint
Published: 1998
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52. Shock Acceleration and Gamma-Ray Emitting Supernova Remnants

Author: Baring, Matthew G., Ellison, Donald C., Reynolds, Stephen P., Grenier, Isabelle A., and Goret, Philippe
Subjects: Astrophysics
Abstract: Diffusive shock acceleration in the environs of a remnant's expanding shell is a popular candidate for the origin of SNR gamma-rays. In this paper, results from our study of non-linear effects in shock acceleration theory and their impact on the gamma-ray spectra of SNRs are presented. These effects describe the dynamical influence of the accelerated cosmic rays on the shocked plasma at the same time as addressing how the non-uniformities in the fluid flow force the distribution of the cosmic rays to deviate from pure power-laws. Such deviations are crucial to gamma-ray spectral determination. Our self-consistent Monte Carlo approach to shock acceleration is used to predict ion and electron distributions that spawn neutral pion decay, bremsstrahlung and inverse Compton emission components for SNRs. We demonstrate how the spatial and temporal limitations imposed by the expanding SNR shell quench acceleration above critical energies in the 500 GeV - 10 TeV range, thereby spawning gamma-ray spectral cutoffs that are quite consistent with Whipple's TeV upper limits to the EGRET unidentified sources that have SNR associations. We also discuss the role of electron injection in shocks and its impact on the significance of electromagnetic components to GeV--TeV spectral formation., Comment: 6 pages, including 2 eps figures, to appear in "Towards a Major Atmospheric Cerenkov Detector," Proc. Kruger National Park TeV Workshop, (1997) ed. O. C. de Jager (Wesprint, Pochefstroom)
Published: 1997

53. Spectrum and Variability of Mrk501 as observed by the CAT Imaging Telescope

Author: Barrau, A., Bazer-Bachi, R., Cabot, H., Chounet, L. M., Debiais, G., Degrange, B., Dezalay, J. P., Djannati-Atai, A., Dumora, D., Espigat, P., Fabre, B., Fleury, P., Fontaine, G., George, R., ghesquiere, C., Goret, P., Gouiffes, C., Grenier, I. A., Iacoucci, L., Bohec, S. Le, Malet, I., Meynadier, C., Munz, P., Palfrey, T. A., Pare, E., Pons, Y., Punch, M., Quebert, J., Ragan, K., Renault, C., Rivoal, M., Rob, L., Schovanek, P., Smith, D., Tavernet, J. P., and Vrana, J.
Subjects: Astrophysics
Abstract: The CAT Imaging Telescope has observed the BL Lac object Markarian 501 between March and August 1997. We report here on the variability over this time including several large flares. We present also preliminary spectra for all these data, for the low emission state, and for the largest flare., Comment: 4 pages, 4 figures, Latex
Published: 1997

54. Performances of the CAT imaging telescope and some preliminary results on Mkn 180 and the Crab

Author: Barrau, A., Bazer-Bachi, R., Cabot, H., Chounet, L. M., Debiais, G., Degrange, B., Dezalay, J. P., Djannati-Atai, A., Dumora, D., Espigat, P., Fabre, B., Fleury, P., Fontaine, G., George, R., Ghesquiere, C., Goret, P., Gouiffes, C., Grenier, I. A., Iacoucci, L., Bohec, S. Le, Malet, I., Meynadier, C., Munz, P., Palfrey, T. A., Pare, E., Pons, Y., Punch, M., Quebert, J., Ragan, K., Renault, C., Rivoal, M., Rob, L., Schovanek, P., Smith, D., Tavernet, J. P., and Vrana, J.
Subjects: Astrophysics
Abstract: The CAT imaging telesope, which uses the Atmospheric Cherenkov Technique to observe TeV gamma-ray sources, has been operating since September 1996. Located in southern France, it features a fine grained camera consisting of 546 PMT with a pixel size of 0.12 degrees. Strong gamma-ray signals from Mkn 501 above 200 GeV were detected during observations made in April 1997. The high signal/noise ratio for these data enables direct characterization of the gamma-ray images as recorded in the camera. These results are used to validate the Monte-Carlo simulations of the response of the telescope to gamma-ray showers and to improve its performances. Observational results on Mkn 180 and the Crab nebula spectrum are presented., Comment: 6 pages, 3 figures, Latex
Published: 1997

55. Detection of Vhe Gamma-Rays from MRK 501 with the Cat Imaging Telescope

Author: Barrau, A., Bazer-Bachi, R., Cabot, H., Chounet, L. M., Debiais, G., Degrange, B., Dezalay, J. P., Djannati-Atai, A., Dumora, D., Espigat, P., Fabre, B., Fleury, P., Fontaine, G., George, R., Ghesquiere, C., Goret, P., Gouiffes, C., Grenier, I. A., Iacoucci, L., Bohec, S. Le, Mallet, I., Meynadier, C., Munz, F., Palfrey, T. A., Pare, E., Pons, Y., Punch, M., Quebert, J., Ragan, K., Renault, C., Rivoal, M., Rob, L., Schovanek, P., Smith, D., Tavernet, J. P., and Vrana, J.
Subjects: Astrophysics
Abstract: The CAT imaging telescope on the site on the former solar plant Themis has been observing gamma-rays from Mrk501 above 220 GeV in March and April 1997. This source is shown to be highly variable and the light curve is presented. The detected gamma-ray rate for the most intense flare is in excess of 10 per minute., Comment: 5 pages, 4 figures, Tex, contribution to 25th ICRC Durban
Published: 1997

56. The CAT Imaging Telescope

Author: Barrau, A., Bazer-Bachi, R., Cabot, H., Chounet, L. M., Debiais, G., Degrange, B., Dezalay, J. P., Djannati-Atai, A., Dumora, D., Espigat, P., Fabre, B., Fleury, P., Fontaine, G., George, R., Ghesquiere, C., Goret, P., Gouiffes, C., Grenier, I. A., Iacoucci, L., Bohec, S. Le, Mallet, I., Meynadier, C., Munz, F., Palfrey, T. A., Pare, E., Pons, Y., Punch, M., Quebert, J., Ragan, K., Renault, C., Rivoal, M., Rob, L., Schovanek, P., Smith, D., Tavernet, J. P., and Vrana, J.
Subjects: Astrophysics
Abstract: The VHE gamma-ray imaging telescope CAT started taking data in October 1996. Located at the Themis solar site in southern France, it features a 17.7 m^2 Davies-Cotton mirror equipped with 600 PMT camera at the focal plane. The mechanics and optics, the PMTs and the electronics are presented. The performance, based on the first 7 months of operation, is discribed., Comment: 4 pages, 2 figures, Tex, contribution to 25th ICRC Durban
Published: 1997

57. Observation of the Crab Nebula Gamma-Ray Emission Above 220 Gev by the Cat Cherenkov Imaging Telescope

Author: Barrau, A., Bazer-Bachi, R., Cabot, H., Chounet, L. M., Debiais, G., Degrange, B., Dezalay, J. P., Djannati-Atai, A., Dumora, D., Espigat, P., Fabre, B., Fleury, P., Fontaine, G., George, R., Ghesquiere, C., Goret, P., Gouiffes, C., Grenier, I. A., Iacoucci, L., Bohec, S. Le, Mallet, I., Meynadier, C., Munz, F., Palfrey, T. A., Pare, E., Pons, Y., Punch, M., Quebert, J., Ragan, K., Renault, C., Rivoal, M., Rob, L., Schovanek, P., Smith, D., Tavernet, J. P., and Vrana, J.
Subjects: Astrophysics
Abstract: The CAT imaging telescope, recently built on the site of the former solar plant Themis (French Pyrenees), observed gamma-rays from the Crab nebula from October 1996 to March 1997. This steady source, often considered as the standard candle of very-high-energy gamma-ray astronomy, is used as a test-beam to probe the performances of the new telescope, particularly its energy threshold (220 GeV at 20 degrees zenith angle) and the stability of its response. Due to the fine-grain camera, an accurate analysis of the longitudinal profiles of shower images is performed, yielding the source position in two dimensions for each individual shower., Comment: 5 pages, 3 figures, Tex, contribution to 25th ICRC Durban
Published: 1997

58. Inclusion of CO2 flux modelling in an urban canopy layer model and an evaluation over an old European city centre

Author: Marine Goret, Valéry Masson, Robert Schoetter, and Marie-Pierre Moine
Subjects: Environmental pollution, TD172-193.5, Meteorology. Climatology, QC851-999
Abstract: In the context of climate change, the reduction of greenhouse gas emissions is a global concern. Recent publications estimate that 30–40% of total anthropogenic greenhouse gases are directly emitted by urban areas. This paper focuses on CO2, which is the main anthropogenic greenhouse gas, and presents an implementation of CO2 flux modelling in urban areas within the urban canopy model Town Energy Balance (TEB). Highly weather-dependent contributors to CO2 fluxes (buildings and vegetation) are explicitly modelled by TEB using the Building Energy Model (BEM) for buildings and Interactions between Soil, Biosphere and Atmosphere (ISBA) for urban vegetation. This approach allows the impacts of the urban microclimate on CO2 fluxes to be simulated. Non-weather-dependent contributors (traffic and human respiration) are simulated using simpler approaches. A sensitivity study applied to the centre of Toulouse, France, highlights the relevance of detailed input data related to traffic, building use and human behaviour to simulate accurate CO2 fluxes. The results show that traffic (48.5%) and buildings (42%) are the main contributors to the annual mean CO2 flux. A comparison of the model results with independent eddy-covariance flux data shows good agreement with a root mean square error of 15.3 μmol m−2 s−1 and demonstrates that the model is able to reproduce seasonally averaged daily cycles of CO2 fluxes. In future studies, this model can be used to quantify the impacts on CO2 fluxes of different urban development scenarios such as urban expansion, changes in urban form, changes in practices related to the heating of buildings or urban greening strategies. Keywords: CO2fluxes, Eddy covariance, Cities, Urban canopy layer model, Model evaluation
Published: 2019
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59. Decreased susceptibility to chlorhexidine affects a quarter of Escherichia coli isolates responsible for pneumonia in ICU patients

Author: La Combe, Béatrice, Bleibtreu, Alexandre, Messika, Jonathan, Fernandes, Romain, Clermont, Olivier, Branger, Catherine, Billard-Pomares, Typhaine, Barnaud, Guilène, Magdoud, Fatma, Eveillard, Matthieu, Kouatchet, Achille, Lasocki, Sigismond, Asfar, Pierre, Corvec, Stéphane, Lakhal, Karim, Armand-Lefevre, Laurence, Wolff, Michel, Timsit, Jean-François, Bourdon, Sandrine, Reignier, Jean, Martin, Stéphanie, Fihman, Vincent, de Prost, Nicolas, Bador, Julien, Charles, Pierre-Emmanuel, Goret, Julien, Boyer, Alexandre, Wallet, Frederic, Jaillette, Emmanuelle, Nseir, Saad, Landraud, Luce, Ruimy, Raymond, Danin, Pierre-Eric, Dellamonica, Jean, Cremniter, Julie, Frat, Jean-Pierre, Jauréguy, Françoise, Clec’h, Christophe, Decré, Dominique, Maury, Eric, Dreyfuss, Didier, Denamur, Erick, and Ricard, Jean-Damien
Published: 2018
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60. Opportunistic Pulmonary Bordetella hinzii Infection after Avian Exposure

Author: Aude Fabre, Clarisse Dupin, François Bénézit, Julien Goret, Caroline Piau, Stéphane Jouneau, Sophie Guillot, Francis Mégraud, Samer Kayal, Benoit Desrues, Alain Le Coustumier, and Nicole Guiso
Subjects: Bordetella hinzii, opportunistic pulmonary infection, avian exposure, persistence, bacteria, France, Medicine, Infectious and parasitic diseases, RC109-216
Abstract: We report 2 cases of pulmonary Bordetella hinzii infection in immunodeficient patients. One of these rare cases demonstrated the potential transmission of the bacteria from an avian reservoir through occupational exposure and its persistence in humans. We establish bacteriologic management of these infections and suggest therapeutic options if needed.
Published: 2015
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61. Short- and Long-term Influence of Litter Quality and Quantity on Simulated Heterotrophic Soil Respiration in a Lowland Tropical Forest

Author: Bréchet, Laëtitia, Le Dantec, Valérie, Ponton, Stéphane, Goret, Jean-Yves, Sayer, Emma, Bonal, Damien, Freycon, Vincent, Roy, Jacques, and Epron, Daniel
Published: 2017
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62. A giant chorioangioma of the placenta with favorable outcome: a rare case presentation with literature review

Author: Fatma Beyazit, Ceren Canbey Goret, Eren Pek, and Meryem Gencer
Subjects: pregnancy, placenta, chorioangoma, Medicine
Abstract: Chorioangioma, or hemangioma of the placenta, is the most frequent non-trophoblastic tumor of the placenta consisting of blood vessels and stroma. A great proportion of these tumors are small and well delineated within the placental parenchyma and have no or minimal adverse impact on the fetus. Unfortunately, large tumor size is linked to serious complications such as fetal anemia, hydrops and intrauterine death. This is probably because of arteriovenous shunts leading to progressive heart failure of the fetus. With the increasing rates of antenatal screenings with ultrasonography, prenatal diagnosis of these tumors is widely achieved. Here we report a case of giant placental chorioangioma diagnosed in the second trimester of pregnancy. The size of the tumor minimally increased during follow-up and at term, uncomplicated labor was achieved. Macroscopic and histologic examination confirmed the diagnosis. [Med-Science 2016; 5(4.000): 1037-9]
Published: 2016
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63. Prevalence and pathogenicity of binary toxin–positive Clostridium difficile strains that do not produce toxins A and B

Author: C. Eckert, A. Emirian, A. Le Monnier, L. Cathala, H. De Montclos, J. Goret, P. Berger, A. Petit, A. De Chevigny, H. Jean-Pierre, B. Nebbad, S. Camiade, R. Meckenstock, V. Lalande, H. Marchandin, and F. Barbut
Subjects: A−B−CDT+ strains, binary toxin, diagnostic, PCR ribotype 033, toxinotype XI, Clostridium difficileI, Infectious and parasitic diseases, RC109-216
Abstract: Clostridium difficile causes antibiotic-associated diarrhoea and pseudomembranous colitis. The main virulence factors of C. difficile are the toxins A (TcdA) and B (TcdB). A third toxin, called binary toxin (CDT), can be detected in 17% to 23% of strains, but its role in human disease has not been clearly defined. We report six independent cases of patients with diarrhoea suspected of having C. difficile infection due to strains from toxinotype XI/PCR ribotype 033 or 033-like, an unusual toxinotype/PCR ribotype positive for CDT but negative for TcdA and TcdB. Four patients were considered truly infected by clinicians and were specifically treated with oral metronidazole. One of the cases was identified during a prevalence study of A−B−CDT+ strains. In this study, we screened a French collection of 220 nontoxigenic strains and found only one (0.5%) toxinotype XI/PCR ribotype 033 or 033-like strain. The description of such strains raises the question of the role of binary toxin as a virulence factor and could have implications for laboratory diagnostics that currently rarely include testing for binary toxin.
Published: 2015
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64. Les sous-classes d'IgG dans le LCR présentent-elles un réel intérêt ?

Author: Martinroche, Guillaume, Charpy, Juliette, and Goret, Julien
Abstract: Le dosage des IgG totales sur sérum est un examen courant de biologie médicale. Plus spécialisé, le dosage des sous- classes d'IgG sur sérum trouve sa place en deuxième ligne lors d'un bilan de déficit immunitaire ou pour la maladie associée aux IgG4 (MAG4). Dans le liquide céphalorachidien, leur évaluation permet la distinction entre un transsudat et une synthèse intrathécale. Concernant les sous-classes d'IgG dans le LCR, les laboratoires de biologie médicale commencent à recevoir des demandes, afin de mettre en évidence la présence d'IgG4. Dans le LCR elles seraient liées à la pachyméningite hypertrophique associée à la MAG4 mais, en l'absence d'étude clinique de grande envergure, leur dosage ne semble être pertinent que lorsque la biopsie tissulaire est impossible. La technique de dosage validée sur sérum est quantitative en milieu liquide (néphélémétrie/turbidimétrie). L'utilisation de ces techniques sur LCR doit être validée par chaque laboratoire, en l'absence de validation des kits sur LCR. Cette revue actualisée de la littérature revient sur les différentes indications des dosages d'IgG et des sous-classes d'IgG sur sérum, sur l'intérêt du dosage des sous- classes d'IgG sur le LCR et les techniques associées. Serum total IgG measurement is a common lab act in medical biology. More specialized, serum IgG subclasses measurement plays a key role in IgG4-Re- lated Disease but is also useful for second-line diagnosis in humoral immune deficiencies. In the cerebrospinal fluid (CSF), an index is used as an indicator of the relative amount of CSF IgG compared to serum. Any increase in the index reflects IgG production in the central nervous system. Regarding IgG subclasses in the CSF, medical laboratories are now getting demands, actually to find out if there is any IgG4 subclass. These IgG4 in CSF could be associated with IgG4-related hypertrophic pachymeningitis but without appropriate studies corroborating this, their measurement should be done only when tissue biopsy cannot be performed. Quantitative measurement on serum is validated with nephelometry and turbidimetry assays. Each laboratory has to validate the assays on CSF before giving results. In this mini review, we present the indications of total IgG and IgG subclasses on serum as well as the benefit of IgG subclasses in CSF and the techniques available in a medical laboratory. [ABSTRACT FROM AUTHOR]
Published: 2023
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65. Impact of the introduction of a nucleic acid amplification test for Clostridium difficile diagnosis on stool rejection policies

Author: Goret, J., Blanchi, J., Floch, P., Peuchant, O., Chrisment, D., Sanchez, R., Biessy, H., Lemarié, R., Leyssene, D., Loutfi, B., Mimouni, S., Flao, T., Bébéar, C., and Mégraud, F.
Published: 2018
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66. La fouille de l’îlot Cygne à Saint-Denis

Author: Christelle Chamousset and Jean-François Goret
Subjects: Archaeology, CC1-960
Published: 2011
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67. Regional and seasonal patterns of litterfall in tropical South America

Author: J. Chave, D. Navarrete, S. Almeida, E. Álvarez, L. E. O. C. Aragão, D. Bonal, P. Châtelet, J. E. Silva-Espejo, J.-Y. Goret, P. von Hildebrand, E. Jiménez, S. Patiño, M. C. Peñuela, O. L. Phillips, P. Stevenson, and Y. Malhi
Subjects: Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract: The production of aboveground soft tissue represents an important share of total net primary production in tropical rain forests. Here we draw from a large number of published and unpublished datasets (n=81 sites) to assess the determinants of litterfall variation across South American tropical forests. We show that across old-growth tropical rainforests, litterfall averages 8.61±1.91 Mg ha−1 yr−1 (mean ± standard deviation, in dry mass units). Secondary forests have a lower annual litterfall than old-growth tropical forests with a mean of 8.01±3.41 Mg ha−1 yr−1. Annual litterfall shows no significant variation with total annual rainfall, either globally or within forest types. It does not vary consistently with soil type, except in the poorest soils (white sand soils), where litterfall is significantly lower than in other soil types (5.42±1.91 Mg ha−1 yr−1). We also study the determinants of litterfall seasonality, and find that it does not depend on annual rainfall or on soil type. However, litterfall seasonality is significantly positively correlated with rainfall seasonality. Finally, we assess how much carbon is stored in reproductive organs relative to photosynthetic organs. Mean leaf fall is 5.74±1.83 Mg ha−1 yr−1 (71% of total litterfall). Mean allocation into reproductive organs is 0.69±0.40 Mg ha−1 yr−1 (9% of total litterfall). The investment into reproductive organs divided by leaf litterfall increases with soil fertility, suggesting that on poor soils, the allocation to photosynthetic organs is prioritized over that to reproduction. Finally, we discuss the ecological and biogeochemical implications of these results.
Published: 2010
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68. État des connaissances et besoins en formation en biologie de l'allergie : enquête du Groupe de Travail Biologie de l'Allergie de la Société française d'allergologie à l'intention des jeunes allergologues.

Author: Goret, J., Sève, E., and Klingebiel, C.
Abstract: La biologie est un outil incontournable dans le diagnostic et la prise en charge des patients allergiques. L'apprentissage à l'interprétation d'un bilan biologique est essentiel pour le praticien. En raison de la diversité des cursus, les jeunes allergologues n'ont pas tous la même formation. À la demande du Conseil Scientifique de la Société française d'allergologie (SFA), le Groupe de Travail Biologie de l'Allergie a réalisé une enquête auprès des jeunes allergologues afin d'évaluer leur niveau de formation en biologie de l'allergie et de connaître leurs attentes en termes de formation continue. Au total, 162 allergologues ont été contactés et 36 ont répondu. Les répondants étaient majoritairement des femmes (78 %), allergologues exclusifs (83 %) et 69 % étaient issus du DES d'Allergologie. La moitié estimait avoir eu une formation suffisante en biologie de l'allergie et 50 % ont effectué un stage dans un laboratoire de biologie médicale. Soixante-trois pour cent se considéraient comme compétents pour l'interprétation des bilans. Pour leur formation continue, ils utilisaient les sites internet des sociétés savantes, les revues scientifiques et des webinaires qu'ils jugeaient satisfaisants. Aucune personne n'avait recours à un système d'évaluation des compétences. Plus de 95 % des répondants sont en faveur d'une mise à disposition de documents synthétiques de référence et tous les consulteraient s'ils étaient accessibles en ligne sur le site de la SFA. En conclusion, la formation des jeunes allergologues sur la biologie de l'allergie a besoin d'être complétée et harmonisée, sur le plan théorique et pratique. Plusieurs outils pédagogiques sont plébiscités pour le maintien des compétences. Blood tests are an essential tool for the diagnosis and management of allergy. Learning how to interpret test results is therefore essential for the physician. Due to the diversity of their education, young allergists do not all have the same training. At the request of the French Society of Allergology (SFA) Scientific Committee, the In vitro Diagnosis Working Group carried out a survey for young allergists in order to evaluate their level of initial training in allergy in vitro diagnosis and to know their expectations in terms of continuing medical education. A total of 162 allergists were consulted and 36 responded. Half of them considered that they had sufficient training in allergy in vitro diagnosis and 50% considered themselves competent in the interpretation of tests. For their continuing medical education, they use the websites of learned societies (SFA, EEACI), scientific journals and webinars and consider them satisfactory or very satisfactory. More than 95% of them are in favour of the online availability of summary sheets or reference documents in in vitro diagnosis, and all of them would consult these tools if they were accessible on the SFA website. In conclusion, the training of young allergists in allergy blood tests needs to be completed and standardised, both theoretically and practically. Several educational tools are available and popular to achieve this and help them to keep valuable skills up to date. [ABSTRACT FROM AUTHOR]
Published: 2022
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69. Seasonal variations in stem CO2 efflux in the Neotropical rainforest of French Guiana

Author: Stahl, Clément, Burban, Benoit, Goret, Jean-Yves, and Bonal, Damien
Published: 2011
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70. Virulence potential and genomic mapping of the worldwide clone Escherichia coli ST131.

Author: Jean-Philippe Lavigne, Annette C Vergunst, Lucie Goret, Albert Sotto, Christophe Combescure, Jorge Blanco, David O'Callaghan, and Marie-Hélène Nicolas-Chanoine
Subjects: Medicine, Science
Abstract: Recently, the worldwide propagation of clonal CTX-M-15-producing Escherichia coli isolates, namely ST131 and O25b:H4, has been reported. Like the majority of extra-intestinal pathogenic E. coli isolates, the pandemic clone ST131 belongs to phylogenetic group B2, and has recently been shown to be highly virulent in a mouse model, even though it lacks several genes encoding key virulence factors (Pap, Cnf1 and HlyA). Using two animal models, Caenorhabditis elegans and zebrafish embryos, we assessed the virulence of three E. coli ST131 strains (2 CTX-M-15- producing urine and 1 non-ESBL-producing faecal isolate), comparing them with five non-ST131 B2 and a group A uropathogenic E. coli (UPEC). In C. elegans, the three ST131 strains showed intermediate virulence between the non virulent group A isolate and the virulent non-ST131 B2 strains. In zebrafish, the CTX-M-15-producing ST131 UPEC isolates were also less virulent than the non-ST131 B2 strains, suggesting that the production of CTX-M-15 is not correlated with enhanced virulence. Amongst the non-ST131 B2 group isolates, variation in pathogenic potential in zebrafish embryos was observed ranging from intermediate to highly virulent. Interestingly, the ST131 strains were equally persistent in surviving embryos as the non-ST131-group B2 strains, suggesting similar mechanisms may account for development of persistent infection. Optical maps of the genome of the ST131 strains were compared with those of 24 reference E. coli strains. Although small differences were seen within the ST131 strains, the tree built on the optical maps showed that these strains belonged to a specific cluster (86% similarity) with only 45% similarity with the other group B2 strains and 25% with strains of group A and D. Thus, the ST131 clone has a genetic composition that differs from other group B2 strains, and appears to be less virulent than previously suspected.
Published: 2012
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71. A low level of extragalactic background light as revealed by γ-rays from blazars

Author: Aharonian, F., Akhperjanian, A. G., Bazer-Bachi, A. R., Beilicke, M., Benbow, W., Berge, D., Bernlöhr, K., Boisson, C., Bolz, O., Borrel, V., Braun, I., Breitling, F., Brown, A. M., Chadwick, P. M., Chounet, L.-M., Cornils, R., Costamante, L., Degrange, B., Dickinson, H. J., Djannati-Ataï, A., Drury, L. O'C., Dubus, G., Emmanoulopoulos, D., Espigat, P., Feinstein, F., Fontaine, G., Fuchs, Y., Funk, S., Gallant, Y. A., Giebels, B., Gillessen, S., Glicenstein, J. F., Goret, P., Hadjichristidis, C., Hauser, D., Hauser, M., Heinzelmann, G., Henri, G., Hermann, G., Hinton, J. A., Hofmann, W., Holleran, M., Horns, D., Jacholkowska, A., de Jager, O. C., Khélifi, B., Klages, S., Komin, Nu., Konopelko, A., Latham, I. J., Le Gallou, R., Lemière, A., Lemoine-Goumard, M., Leroy, N., Lohse, T., Martin, J. M., Martineau-Huynh, O., Marcowith, A., Masterson, C., McComb, T. J. L., de Naurois, M., Nolan, S. J., Noutsos, A., Orford, K. J., Osborne, J. L., Ouchrif, M., Panter, M., Pelletier, G., Pita, S., Pühlhofer, G., Punch, M., Raubenheimer, B. C., Raue, M., Raux, J., Rayner, S. M., Reimer, A., Reimer, O., Ripken, J., Rob, L., Rolland, L., Rowell, G., Sahakian, V., Saugé, L., Schlenker, S., Schlickeiser, R., Schuster, C., Schwanke, U., Siewert, M., Sol, H., Spangler, D., Steenkamp, R., Stegmann, C., Tavernet, J.-P., Terrier, R., Théoret, C. G., Tluczykont, M., van Eldik, C., Vasileiadis, G., Venter, C., Vincent, P., Völk, H. J., and Wagner, S. J.
Published: 2006
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72. CENÁRIOS PARA O SETOR DE TRANSPORTES NO BRASIL

Author: Goret P. Paulo, Carlos E. C. Montagna, Pedro Roquete, Alexandre P.Z. Carneiro, Maria Carolina Costa Guedes, Eliane Coutinho Costa Guedes, Elaine Coutinho Schulze, Ligia Barros das Chagas, and Rafael Bergman
Subjects: Transportation engineering, TA1001-1280
Abstract: O Grupo Shell começou a utilizar a técnica de cenários em seu processo de planejamento no final dos anos 60. Isto foi feito depois de constatar que a velocidade de mudanças no meio ambiente tinha chegado a tal ponto que não permitiria mais o uso de projeções lineares baseadas em comportamentos históricos. Era necessário desenvolver uma técnica que permitisse vislumbrar as tendências de mudanças de comportamento do meio ambiente antes de ser surpreendido por elas. A crescente complexidade da relação entre todas as variáveis que influenciam o meio ambiente e a rapidez com que as mudanças acontecem fazem com que o futuro seja muito mais imprevisível hoje do que há 100 anos atrás. Possivelmente os estrategistas daquela época achavam o mesmo do período anterior, uma vez que a velocidade de mudança parece estar em constante aceleração. Desta forma, planejamento torna-se um processo de aprendizado e cenários um importante instrumento deste processo.
Published: 2010

73. On cosmic-ray cut-off terminology

Author: Cooke, D. J., Humble, J. E., Shea, M. A., Smart, D. F., Lund, N., Rasmussen, I. L., Byrnak, B., Goret, P., and Petrou, N.
Published: 1991
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74. MASS-SAT: Matter-Antimatter Space Spectrometer on Satellite

Author: Basini, G., Candusso, M., Massimo Brancaccio, F., Ricci, M., Bocciolini, M., Spillantini, P., Wang, Yi. -F., Bongiorno, F., De Pascale, M. P., Morselli, A., Picozza, P., De Marzo, C., Erriquez, O., Barbiellini, G., Vacchi, A., Galeotti, P., Ballocchi, G., Simon, M., Carlson, P., Goret, P., and Golden, R. L.
Published: 1990
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75. NOVEOS and ImmunoCAP Have Similar Performances for Diagnosing Food Allergies

Author: Trouche-Estival, Benjamin, Vitte, Joana, Martin-Blondel, Audrey, Michelet, Marine, Gruzelle, Vianney, Didier, Alain, Guilleminault, Laurent, Mailhol, Claire, Rivera, Silvia Martinez, De Lima Correia, Anaïs, Taurus, Camille, Blancher, Antoine, Goret, Julien, Klingebiel, Caroline, and Apoil, Pol André
Abstract: The clinical significance of newly available platforms for specific IgE measurement must be evaluated. However, data are lacking for NOVEOS (Hycor), especially for food allergens.
Published: 2024
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76. CENÁRIOS PARA O SETOR DE TRANSPORTES NO BRASIL

Author: Goret P. Paulo, Carlos E. C. Montagna, Pedro Roquete, Alexandre P.Z. Carneiro, Maria Carolina Costa Guedes, Eliane Coutinho Costa Guedes, Elaine Coutinho Schulze, Ligia Barros das Chagas, and Rafael Bergman
Subjects: Transportation engineering, TA1001-1280
Abstract: O Grupo Shell começou a utilizar a técnica de cenários em seu processo de planejamento no final dos anos 60. Isto foi feito depois de constatar que a velocidade de mudanças no meio ambiente tinha chegado a tal ponto que não permitiria mais o uso de projeções lineares baseadas em comportamentos históricos. Era necessário desenvolver uma técnica que permitisse vislumbrar as tendências de mudanças de comportamento do meio ambiente antes de ser surpreendido por elas. A crescente complexidade da relação entre todas as variáveis que influenciam o meio ambiente e a rapidez com que as mudanças acontecem fazem com que o futuro seja muito mais imprevisível hoje do que há 100 anos atrás. Possivelmente os estrategistas daquela época achavam o mesmo do período anterior, uma vez que a velocidade de mudança parece estar em constante aceleração. Desta forma, planejamento torna-se um processo de aprendizado e cenários um importante instrumento deste processo.
Published: 1997
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77. Evaluation of the positive predictive value of a rapid Immunochromatographic test to detect Campylobacter in stools

Author: Floch Pauline, Goret Julien, Bessède Emilie, Lehours Philippe, and Mégraud Francis
Subjects: Culture, ELISA, PCR, Specificity, Near-patient test, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Abstract The recently developed rapid immunochromatographic tests (ICT) have the potential to provide a quick and easy diagnosis of Campylobacter enteritis in comparison to culture. In a previous study we found them sensitive but lacking in specificity. The aim of the present study was to focus on the problem of specificity and determine the positive predictive value (PPV) of a positive result of the ImmunoCard Stat! Campy (Meridian Bioscience, Cincinnati, OH, USA). For this purpose, the stools positive by ICT were cultured according to 3 different protocols: Karmali agar, Preston enrichment broth subcultured on Karmali agar, and a filtration method on a blood agar without antibiotics, all incubated for 7 days at 37°C. Out of 609 stools from adults and children with community acquired enteritis, the reference methods detected 25 positive cases (4.1%) (culture: 19, specific PCR and ELISA both positive: 6) and the ICT: 31 including the 25 true positives. The PPV was 80.6%. We conclude that ICT is a good method to screen Campylobacter positive stools but because of its lack of specificity the positive stools must be tested by another method.
Published: 2012
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78. Effect of Local Anesthesia on Pain During Arterial Puncture: The GAEL Randomized Placebo-Controlled Trial.

Author: Beaumont, Marc, Goret, Marion, Orione, Charles, Fauche, Alexandre, Nowak, Emmanel, Dion, Angelina, Darnois, Veronique, Tromeur, Cecile, Cogulet, Virginie, Leroyer, Christophe, Couturaud, Francis, and Le Mao, Raphael
Subjects: STATISTICS, PAIN, CONFIDENCE intervals, LOCAL anesthesia, ARTERIAL puncture, TREATMENT effectiveness, RANDOMIZED controlled trials, BLIND experiment, DESCRIPTIVE statistics, STATISTICAL sampling, DATA analysis, DATA analysis software, PAIN management
Abstract: BACKGROUND: Arterial puncture is often painful for patients. The aim of this study was to compare use of local anesthesia as a eutectic mixture of 2 local anesthetics, lidocaine and prilocaine, versus placebo. METHODS: We conducted a double-blind, randomized controlled trial. Subjects were eligible if arterial puncture was indicated. The primary outcome was an experienced pain > 2 on a numerical pain rating scale. As having had a previous experience of arterial puncture was expected to be predictive of the current response, we planned 3 comparisons between use of local anesthesia and placebo: in the whole sample, among subjects with a painful previous experience, and among subjects with a painless previous experience. Multiple testing was analyzed using the Bonferroni correction for the primary outcome. The secondary outcome was the numerical pain rating scale score itself. All analyses were performed on an intention-to-treat basis. RESULTS: A total of 136 subjects were included in this study. The primary outcome occurred in 20.9% in the active arm versus 37.7% in the placebo arm in the whole sample (relative risk 0.55; 95% CI when adjusting for multiple testing ranged was 0.28-1.09, P = .10; 95% CI without adjustment was 0.32-0.97, P = .038). No significant heterogeneity in the study treatment effect was found when considering previous painful or painless arterial puncture (P = .70). The numerical pain rating scale score was 1.55 6 2.03 in active group versus 2.09 « 2.15 in the placebo group (P = .13). CONCLUSIONS: We found that application of a eutectic mixture reduced the number of painful arterial punctures by 50% compared with placebo. However, this result was not statistically significant. (ClinicalTrials.gov registration NCT01964248.) [ABSTRACT FROM AUTHOR]
Published: 2021
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79. Développement et évaluation d'approches algorithmiques et par GAN pour la génération de données synthétiques en Allergologie.

Author: Corriger, J. and Goret, J.
Abstract: Copyright of Revue Francaise d'Allergologie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2024
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80. Allergie versus parasitose : du concept de réponse immunitaire de type 2 à la pratique.

Author: Charpy, J., Klingebiel, C., Dubois, M., Michel, M., Apoil, P.-A., and Goret, J.
Published: 2024
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81. Mice with muscle-specific deletion of Bin1recapitulate centronuclear myopathy and acute downregulation of dynamin 2 improves their phenotypes

Author: Silva-Rojas, Roberto, Nattarayan, Vasugi, Jaque-Fernandez, Francisco, Gomez-Oca, Raquel, Menuet, Alexia, Reiss, David, Goret, Marie, Messaddeq, Nadia, Lionello, Valentina M., Kretz, Christine, Cowling, Belinda S., Jacquemond, Vincent, and Laporte, Jocelyn
Abstract: Mutations in the BIN1(Bridging Interactor 1) gene, encoding the membrane remodeling protein amphiphysin 2, cause centronuclear myopathy (CNM) associated with severe muscle weakness and myofiber disorganization and hypotrophy. There is no available therapy, and the validation of therapeutic proof of concept is impaired by the lack of a faithful and easy-to-handle mammalian model. Here, we generated and characterized the Bin1mck−/−mouse through Bin1knockout in skeletal muscle. Bin1mck−/−mice were viable, unlike the constitutive Bin1knockout, and displayed decreased muscle force and most histological hallmarks of CNM, including myofiber hypotrophy and intracellular disorganization. Notably, Bin1mck−/−myofibers presented strong defects in mitochondria and T-tubule networks associated with deficient calcium homeostasis and excitation-contraction coupling at the triads, potentially representing the main pathomechanisms. Systemic injection of antisense oligonucleotides (ASOs) targeting Dnm2(Dynamin 2), which codes for dynamin 2, a BIN1 binding partner regulating membrane fission and mutated in other forms of CNM, improved muscle force and normalized the histological Bin1mck−/−phenotypes within 5 weeks. Overall, we generated a faithful mammalian model for CNM linked to BIN1defects and validated Dnm2ASOs as a first translatable approach to efficiently treat BIN1-CNM.
Published: 2022
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82. Attrapez-les toutes ! Point sur les IgG et leurs sous-classes.

Author: Martinroche, Guillaume, Sarrat, Anne, and Goret, Julien
Abstract: Les dosages d'IgG et de leurs sous-classes sont des examens courants de biologie médicale. Les IgG sériques totales trouvent leur place en première intention dans les diagnostics des déficits immunitaires primitifs ; mais aussi dans leur suivi et celui des traitements par immunoglobulines polyvalentes. Pour les sous-classes d'IgG sériques, elles sont recommandées en deuxième ligne ou pour la maladie associée aux IgG4. Dans le liquide céphalorachidien, l'intérêt porte aujourd'hui sur les IgG qui permettent la distinction entre un transsudat et une synthèse intrathécale. La technique de dosage est quantitative en milieu liquide (néphélémétrie/turbidimétrie). Parmi les difficultés rencontrées, nous retrouvons l'absence de standard international pour les réactifs des sous-classes d'IgG, les discordances entre le dosage des IgG totales et celui des sous-classes dosées individuellement et la mauvaise évaluation des concentrations des IgG4. Dans cette revue actualisée de la littérature nous revenons sur ces difficultés mais aussi sur les améliorations proposées par les fournisseurs. Nous apportons également quelques pistes sur d'autres améliorations encore possibles pour pallier les difficultés qui persistent. Total IgG and IgG subclasses measurements are common lab acts in medical biology. The main indications are primary immunodeficiency's diagnosis and follow-up treatment with multivalent immunoglobulins. IgG subclass measurement plays a key role in IgG4-Related Disease but is also useful for second-line diagnosis in humoral immune deficiencies. In the cerebrospinal fluid, an index is used as an indicator of the relative amount of CSF IgG compared to serum. Any increase in the index is a reflection of IgG production in the central nervous system. There is no reference material allowing standardization of IgG subclass assays, discrepancies between total IgG and sum of IgG subclasses are quite frequent and IgG4 seem to be underestimated and lead to cross reactivity. In this review, we show that the manufacturers along the difficulties encountered during lab routine have made some improvements. In addition, we are making some suggestions for further improvements that can be done to reduce the difficulties that remain. [ABSTRACT FROM AUTHOR]
Published: 2021
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83. Diagnostic de l'hypersensibilité retardée : des mécanismes immunologiques aux tests de diagnostic in vivo et in vitro.

Author: Serrier, Julien, Charpy, Juliette, Cravat, Maxime, Le Mauff, Brigitte, Leon, Anthony, Goret, Julien, and AllergoBioNet
Abstract: Les réactions d'hypersensibilité retardée (HSR) sont définies comme celles qui surviennent plus de six heures après une exposition aux allergènes et font intervenir l'immunité à médiation cellulaire. La peau est l'organe le plus souvent atteint dans les HSR aux produits naturels ou de synthèse ainsi qu'aux médicaments. La plupart des éruptions cutanées sont bénignes et spontanément résolutives, mais certaines sont graves, entraînant un risque élevé de morbidité et de mortalité. Elles doivent être reconnues tôt et gérées rapidement. La démarche diagnostique repose sur une anamnèse exhaustive, des tests in vivo tels que l'intradermoréaction retardée, le patch-test ou le test de provocation orale et des tests biologiques in vitro explorant l'activité de lymphocytes T spécifiques. Les performances de ces tests varient selon les manifestations cliniques. Les avancées concernant l'immunopathogenèse ont permis d'identifier des allèles HLA associés aux manifestations cliniques et ainsi de déterminer des facteurs de prédisposition. Cet article décrit les caractéristiques et la place actuelle de ces tests selon les phénotypes d'HSR. Delayed hypersensitivity reactions (DHR) are defined as reactions that occur more than 6 hours after exposure to small reactive molecules or drugs. The skin is the most often affected organ. Potentially life-threatening severe cutaneous adverse reactions (SCAR) are associated with a high risk of morbidity and mortality. They should be recognized and managed early by clinicians. The diagnostic workup is based on a precise anamnesis, a history of past events, in vivo tests such as delayed intradermal testing, patch-test or oral challenge and in vitro biological tests exploring the specific lymphocyte activity. Advances in understanding the delayed T cell–mediated reactions lead to identification of predisposing of HLA alleles. We describe the performance of these tests regarding the HSR phenotypes. [ABSTRACT FROM AUTHOR]
Published: 2020
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84. Performance comparison between Phadiatop and Sx01 multi-allergen tests for airborne allergy diagnosis.

Author: Seydoux, Mathilde, Charpy, Juliette, Jouzeau, Arc'Hantael, Domingues, Rafael, Kharat, Morteza, Lemarinel, Christophe, and Goret, Julien
Published: 2024
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85. Comparison of Number of Passes and Cytopathological Specimen Adequacy for Thyroid Fine-Needle Aspiration Biopsy in the Absence of an On-Site Pathologist

Author: Kuzan, Taha Yusuf and Canbey Goret, Ceren
Abstract: Aim:Ultrasound-guided fine-needle aspiration biopsy (FNAB) is a reliable, minimally invasive diagnostic method with high sensitivity and specificity in the evaluation of thyroid nodules. Our aim in this retrospective study was to determine if there was a difference in the adequacy ratio based on the number of needle passes in the thyroid FNABs in the absence of rapid on-site evaluation (ROSE) by the pathologist and to determine the optimal needle pass number for FNAB. Methods:Between November 2018 and February 2019, thyroid FNABs of 121 (99 female, 22 male) patients were evaluated retrospectively. Samples for each biopsy were numbered according to the order of retrieval, and 4 pairs of slides were prepared by the radiologist without on-site microscopic evaluation. Cytological results were determined according to the Bethesda classification. Results:The rate of adequacy in the first, second, third, and fourth passes were 76.0, 82.6, 77.7, and 71.2%, respectively. No statistically significant difference was found between these four groups in terms of adequacy (p= 0.21). The adequacy rates of the 1st, 1st+2nd, 1st+2nd+3rd, and cumulative evaluation of all four biopsies were 76.0, 87.6, 90.1, and 91.7%, respectively (p= 0.001). A statistically significant difference was found in the comparison of the 1st biopsy and the cumulative 1st+2nd biopsy in terms of adequacy rates (p= 0.019). However, there was no statistically significant difference between the cumulative 1st+2nd biopsy and the cumulative 1st+2nd+3rd biopsy in terms of adequacy rates (p= 0.54). Conclusions:In cases where ROSE cannot be performed, we recommend a minimum of 2 and a maximum of 3 needle entries for FNAB adequacy with the right technique and preparation.
Published: 2020
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86. Very high energy γ-ray observations of the binary PSR B1259–63/SS2883 around the 2007 Periastron

Author: A. A. Zdziarski, M. K. Daniel, Gavin Rowell, L. Venter, A. C. Clapson, M. C. Medina, T. J. L. McComb, Gilles Henri, Marek Sikora, W. Domainko, P. H. Tam, S. Rosier-Lees, P. Espigat, S. Schwemmer, Cameron B Rulten, Andrea Santangelo, Michal Dyrda, K. Katarzyński, M. Kerschhaggl, Michael Punch, Felix Aharonian, Guillaume Dubus, Jacek Niemiec, B. C. Raubenheimer, B. Giebels, A. R. Bazer-Bachi, F. Brun, O. Tibolla, A. Shalchi, D. Gerbig, M. Panter, J. L. Skilton, O. C. de Jager, S. Schwarzburg, D. Nedbal, M. Vivier, Karl Kosack, Christian Farnier, C. Stegmann, I. Jung, Stefan Wagner, Gisela Anton, Dieter Horns, Pierre Brun, Łukasz Stawarz, B. Rudak, Kathrin Egberts, G. Lamanna, B. Degrange, A. Cheesebrough, J. Dyks, Heinrich J. Völk, P. Vincent, I. D. Davids, Frank M. Rieger, D. Göring, David Maurin, S. Pita, V. Borrel, M. Tluczykont, Y. A. Gallant, Stefan Ohm, G. Coignet, J-F. Olive, Martin Ward, B. Behera, L. Rob, V. Sahakian, G. Vasileiadis, Rolf Bühler, Andreas Quirrenbach, J.-P. Tavernet, A. Hoffmann, J. F. Glicenstein, R. Kossakowski, F. M. Schöck, M. Paz Arribas, G. Heinzelmann, J. Bolmont, Ullrich Schwanke, M. Dalton, A. G. Akhperjanian, R. Steenkamp, G. Pedaletti, J.-P. Lenain, P. M. Chadwick, Francesca Volpe, B. Nicholas, Anna Szostek, F. Dubois, Konrad Bernlöhr, G. Superina, G. Pühlhofer, A. Fiasson, Timothé Boutelier, Emmanuel Moulin, Reinhard Schlickeiser, Hugh Dickinson, V. Marandon, Christo Venter, C. Jahn, U. F. Katz, A. Zech, A. Djannati-Ataï, M. Hauser, C. van Eldik, M. Holleran, M. Renaud, D. Hauser, D. Klochkov, Catherine Boisson, Rafal Moderski, Dimitrios Emmanoulopoulos, H. Sol, R. C. G. Chaves, S. M. Rayner, J. P. Vialle, P. Goret, Guy Pelletier, A. Förster, Martin Raue, S. Hoppe, A. Charbonnier, S. Heinz, L. O'c. Drury, M. Füßling, E. de Oña Wilhelmi, Sarah Kaufmann, L. Gérard, B. Glück, Nu. Komin, T. Bulik, Christoph Deil, T. Kneiske, I. Büsching, P.-O. Petrucci, L.-M. Chounet, Yvonne Becherini, D. Nekrassov, W. Kluźniak, A. Jacholkowska, G. Fontaine, S. J. Nolan, Jim Hinton, Dmitry Khangulyan, Thomas Lohse, Michał Ostrowski, K. J. Orford, J. Ripken, D. Keogh, Werner Hofmann, U. Barres de Almeida, F. Feinstein, Julien Masbou, Stefano Gabici, M. de Naurois, Alexandre Marcowith, O. Martineau-Huynh, B. Khélifi, G. Hermann, Regis Terrier, J. Ruppel, J. Brucker, D. Spangler, M. Naumann-Godo, F. Stinzing, A. Bochow, Centre d'étude spatiale des rayonnements (CESR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), APC - Astrophysique des Hautes Energies (APC - AHE), Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)-AstroParticule et Cosmologie (APC (UMR_7164)), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), HESS, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, and Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)
Subjects: [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], observational [methods], Flux, Astrophysics, 01 natural sciences, Spectral line, neutron [stars], Pulsar, 0103 physical sciences, Binary star, 010303 astronomy & astrophysics, Astroparticle physics, Physics, 010308 nuclear & particles physics, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], binaries: general [stars], Gamma ray, observations [gamma rays], Astronomy, telescopes, Astronomy and Astrophysics, non-thermal [radiation mechanisms], Light curve, Neutron star, 13. Climate action, Space and Planetary Science
Abstract: Aims. This article presents very-high-energy (VHE; E > 100 GeV) data from the $\gamma$-ray binary PSR B1259-63 as taken during the years 2005, 2006 and before as well as shortly after the 2007 periastron passage. These data extend the knowledge of the lightcurve of this object to all phases of the 3.4 year binary orbit. The lightcurve constrains physical mechanisms present in this TeV source. Methods. Observations of VHE $\gamma$-rays with the HESS telescope array using the Imaging Atmospheric Cherenkov Technique were performed. The HESS instrument features an angular resolution of < 0.1° and an energy resolution of < 20%. Gamma-ray events in an energy range of 0.5-70 TeV were recorded. From these data, energy spectra and lightcurve with a monthly time sampling were extracted. Results. VHE $\gamma$-ray emission from PSR B1259-63 was detected with an overall significance of 9.5 standard deviations using 55h of exposure, obtained from April to August 2007. The monthly flux of $\gamma$-rays during the observation period was measured, yielding VHE lightcurve data for the early pre-periastron phase of the system for the first time. No spectral variability was found on timescales of months. The spectrum is described by a power law with a photon index of $\Gamma$ = 2.8 $\pm$ 0.2stat $\pm$ 0.2sys and flux normalisation $\Phi_{0}$ = (1.1 $\pm$ 0.1stat $\pm$ 0.2sys) $\times$ 10-12 TeV-1 cm-2 s-1. PSR B1259-63 was also monitored in 2005 and 2006, far from periastron passage, comprising 8.9 h and 7.5 h of exposure, respectively. No significant excess of $\gamma$-rays is seen in those observations. Conclusions. PSR B1259-63 has been re-confirmed as a variable TeV $\gamma$-ray emitter. The firm detection of VHE photons emitted at a true anomaly $\theta$$\approx$-0.35 of the pulsar orbit, i.e. already ~50 days prior to the periastron passage, disfavors the stellar disc target scenario as a primary emission mechanism, based on current knowledge about the companion star's disc inclination, extension, and density profile. Results. VHE $\gamma$-ray emission from PSR B1259-63 was detected with an overall significance of 9.5 standard deviations using 55h of exposure, obtained from April to August 2007. The monthly flux of $\gamma$-rays during the observation period was measured, yielding VHE lightcurve data for the early pre-periastron phase of the system for the first time. No spectral variability was found on timescales of months. The spectrum is described by a power law with a photon index of $\Gamma$ = 2.8 $\pm$ 0.2stat $\pm$ 0.2sys and flux normalisation $\Phi_{0}$ = (1.1 $\pm$ 0.1stat $\pm$ 0.2sys) $\times$ 10-12 TeV-1 cm-2 s-1. PSR B1259-63 was also monitored in 2005 and 2006, far from periastron passage, comprising 8.9 h and 7.5 h of exposure, respectively. No significant excess of $\gamma$-rays is seen in those observations. Conclusions. PSR B1259-63 has been re-confirmed as a variable TeV $\gamma$-ray emitter. The firm detection of VHE photons emitted at a true anomaly $\theta$$\approx$-0.35 of the pulsar orbit, i.e. already ~50 days prior to the periastron passage, disfavors the stellar disc target scenario as a primary emission mechanism, based on current knowledge about the companion star's disc inclination, extension, and density profile.
Published: 2009

87. Simultaneous HESS and Chandra observations of Sagitarius A$^{\star}$ during an X-ray flare

Author: F. Aharonian, A. G. Akhperjanian, U. Barres de Almeida, A. R. Bazer-Bachi, Y. Becherini, B. Behera, W. Benbow, K. Bernlöhr, C. Boisson, A. Bochow, V. Borrel, I. Braun, E. Brion, J. Brucker, P. Brun, R. Bühler, T. Bulik, I. Büsching, T. Boutelier, S. Carrigan, P. M. Chadwick, A. Charbonnier, R. C. G. Chaves, A. Cheesebrough, L.-M. Chounet, A. C. Clapson, G. Coignet, M. Dalton, B. Degrange, C. Deil, H. J. Dickinson, A. Djannati-Ataï, W. Domainko, L. O'C. Drury, F. Dubois, G. Dubus, J. Dyks, M. Dyrda, K. Egberts, D. Emmanoulopoulos, P. Espigat, C. Farnier, F. Feinstein, A. Fiasson, A. Förster, G. Fontaine, M. Füßling, S. Gabici, Y. A. Gallant, L. Gérard, B. Giebels, J. F. Glicenstein, B. Glück, P. Goret, C. Hadjichristidis, D. Hauser, M. Hauser, S. Heinz, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, S. Hoppe, D. Horns, A. Jacholkowska, O. C. de Jager, I. Jung, K. Katarzyński, S. Kaufmann, E. Kendziorra, M. Kerschhaggl, D. Khangulyan, B. Khélifi, D. Keogh, Nu. Komin, K. Kosack, G. Lamanna, J.-P. Lenain, T. Lohse, V. Marandon, J. M. Martin, O. Martineau-Huynh, A. Marcowith, D. Maurin, T. J. L. McComb, M. C. Medina, R. Moderski, E. Moulin, M. Naumann-Godo, M. de Naurois, D. Nedbal, D. Nekrassov, J. Niemiec, S. J. Nolan, S. Ohm, J.-F. Olive, E. de Oña Wilhelmi, K. J. Orford, J. L. Osborne, M. Ostrowski, M. Panter, G. Pedaletti, G. Pelletier, P.-O. Petrucci, S. Pita, G. Pühlhofer, M. Punch, A. Quirrenbach, B. C. Raubenheimer, M. Raue, S. M. Rayner, M. Renaud, F. Rieger, J. Ripken, L. Rob, S. Rosier-Lees, G. Rowell, B. Rudak, C. B. Rulten, J. Ruppel, V. Sahakian, A. Santangelo, R. Schlickeiser, F. M. Schöck, R. Schröder, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, J. L. Skilton, H. Sol, D. Spangler, Ł. Stawarz, R. Steenkamp, C. Stegmann, G. Superina, P. H. Tam, J.-P. Tavernet, R. Terrier, O. Tibolla, C. van Eldik, G. Vasileiadis, C. Venter, J. P. Vialle, P. Vincent, M. Vivier, H. J. Völk, F. Volpe, S. J. Wagner, M. Ward, A. A. Zdziarski, A. Zech, Centre d'étude spatiale des rayonnements (CESR), Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), HESS, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), 10859748 - Holleran, Mathew, 12006653 - Venter, Christo, 10179240 - Raubenheimer, Barend Christoffel, 13235176 - Büsching, Ingo, 10065857 - De Jager, Ocker Cornelis, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO)-AstroParticule et Cosmologie (APC (UMR_7164)), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris
Subjects: [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Event horizon, Astrophysics::High Energy Astrophysical Phenomena, Population, FOS: Physical sciences, Flux, Astrophysics, gamma-rays:observations, 01 natural sciences, law.invention, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Coincident, law, 0103 physical sciences, education, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, individuals: Sgr A* [X-rays], Supermassive black hole, education.field_of_study, 010308 nuclear & particles physics, Astrophysics (astro-ph), observations [gamma rays], Astronomy and Astrophysics, X-rays:individual sources:Sgr A, Particle acceleration, Sagittarius A, Space and Planetary Science, individuals: Sgr $A^{\star }$ [X-rays], Flare
Abstract: The rapidly varying (~10 minute timescale) non-thermal X-ray emission observed from Sgr A* implies that particle acceleration is occuring close to the event horizon of the supermassive black hole. The TeV gamma-ray source HESS J1745-290 is coincident with Sgr A* and may be closely related to its X-ray emission. Simultaneous X-ray and TeV observations are required to elucidate the relationship between these objects. We report on joint H.E.S.S./Chandra observations performed in July 2005, during which an X-ray flare was detected. Despite a factor of 9 increase in the X-ray flux of Sgr A*, no evidence is found for an increase in the TeV gamma-ray flux from this region. We find that an increase in the gamma-ray flux of a factor of 2 or greater can be excluded at a confidence level of 99%. This finding disfavours scenarios in which the keV and TeV emission are associated with the same population of accelerated particles and in which the bulk of the gamma-ray emission is produced within ~10^{14} cm (~100 R_S) of the supermassive black hole., 5 pages, 2 figures
Published: 2008

88. Studies of a full-scale mechanical prototype line for the ANTARES neutrino telescope and tests of a prototype instrument for deep-sea acoustic measurements

Author: T. Legou, M. Ruppi, Chantal Compère, R. Ostasch, F. Urbano, Timo Karg, Diego Real, C. Gojak, V. Valente, G. Lamanna, V. Roca, V. Flaminio, C. Fiorello, I. Sokalski, J. Beltramelli, M. Taiuti, E. Kok, A. Rostovtsev, M.C. Bouwhuis, H. Loehner, A. Bigi, Chiara Roda, E. Falchini, Dominique Lefèvre, A. Le Van Suu, R. De Vita, F. Réthoré, V. Popa, H. Zaccone, J.R. Hubbard, Patrick Lamare, S. Cuneo, Julien Lavalle, Annarita Margiotta, K. Fratini, H. Laschinsky, Nicole Béthoux, R. Coniglione, Rosario Megna, C. Petta, L. Caponetto, C. Colnard, G. Wobbe, V. Niess, A. Ceres, Mario Musumeci, N. Randazzo, Thierry Pradier, G. Giacomelli, A. Heijboer, B. Vallage, B. Dinkespieler, J. Poinsignon, G. Damy, H. Le Provost, J. J. Aubert, R. Pillet, Nasser Kalantar-Nayestanaki, G. Vaudaine, G. Lelaizant, J.M. Gallone, F. Schmitt, F. Jouvenot, Paolo Sapienza, M. Jaquet, E. A. De Wolf, J. P. Schuller, G. Rusydi, Elie Aslanides, J. Carr, B. Hartmann, A. F. Yao, Holger Motz, A. Albert, P. Vernin, R. van Dantzig, R. Auer, S. Anvar, Juanan Aguilar, G. Wijnker, K. Salomon, M. de Jong, K. Streeb, Corinne Donzaud, J.J. Hernández-Rey, F. Salesa, J.-P. Pineau, D. Castel, G.V. Russo, S. Loucatos, M. Melissas, Robert Lahmann, Yvonne Becherini, Philippe Charvis, B. van Rens, J. P. Ernenwein, M. Marcelin, R. Masullo, Mohsen Harakeh, M. Circella, Alexander Kappes, F. Cafagna, L. A. M. Tasca, P. Valdy, D. Lo Presti, Gregory David Hallewell, Nathalie Palanque-Delabrouille, W. Kretschmer, V. Bertin, J. van Randwijk, Stephanie Escoffier, P. Payre, Tommaso Chiarusi, J.-L. Fuda, R. Blaes, M. Ageron, N. Cottini, G. Debonis, C. Kopper, V. Lyashuk, H. Peek, F. Lucarelli, S. Mangano, P. Lagier, J.D. Zornoza, M. Battaglieri, J.-X. Dessa, F. Fehr, G. Lim, Guillaume Lambard, Charling Tao, F.E. Ardellier-Desages, V. Rigaud, Jürgen Brunner, J.J. Destelle, E. Barbarito, U. F. Katz, C. Olivetto, S. Kuch, I. Dekeyser, L. Caillat, F. Guilloux, C. Naumann, Ana G. Pérez, F. Louis, P. Goret, C. De Marzo, Christian Tamburini, A. J. Noble, R. Bruijn, J. F. Drogou, T. Spona, F. Feinstein, J. Hößl, L. R. Sulak, M. Naumann-Godo, A. S. Cussatlegras, P. Piattelli, D. Zaborov, A. Kruijer, T. Montaruli, P. Chauchot, G. Loaec, J. Zúñiga, Anne Deschamps, S. Galeotti, Alain Mazure, J. Hogenbirk, Emanuele Castorina, C. Hoffman, G. Riccobene, D. Denans, F. Ameli, Vincenzo Cavasinni, C. Distefano, M. Billault, Y. Le Guen, M. Bazzotti, H. Kok, S. Basa, Eric Delagnes, J.-C. Languillat, M. Ripani, Jean-Francois Rolin, E. Carmona, Antoine Kouchner, G. Terreni, Dominique Durand, S. Cecchini, E. Heine, R. van Wijk, M. Morganti, Kay Graf, P. Coyle, Jean-Paul Kneib, Gisela Anton, T. Stolarczyk, C. Racca, J.-Y. Coail, Marc Régnier, S. Favard, A. Calzas, L. Moscoso, Rezo Shanidze, Antonio Capone, N. Girard, Maurizio Spurio, J. Roux, G. Venekamp, P. Kooijman, M. Jaspers, B. Verlaat, Yann Hello, P. Keller, G. van der Steenhoven, F. Mazéas, M. Anghinolfi, G. F. Burgio, J. Busto, P. Rewiersma, M. Mongelli, E. Migneco, F. Druillole, N. de Botton, High Energy Astrophys. & Astropart. Phys (API, FNWI), ANTARES (IHEF, IoP, FNWI), M. AGERON, J.A. AGUILAR, A. ALBERT, F. AMELI, M. ANGHINOLFI, G. ANTON, S. ANVAR, F. ARDELLIER-DESAGES, E. ASLANIDES, J-J. AUBERT, R. AUER, E. BARBARITO, S. BASA, M. BATTAGLIERI, M. BAZZOTTI, Y. BECHERINI, N. BETHOUX, J. BELTRAMELLI, V. BERTIN, A. BIGI, M. BILLAULT, R. BLAES, N. DE BOTTON, M.C. BOUWHUIS, R. BRUIJN, J. BRUNNER, G.F. BURGIO, J. BUSTO, F. CAFAGNA, L. CAILLAT, A. CALZAS, A. CAPONE, L. CAPONETTO, E. CARMONA, J. CARR, D. CASTEL, E. CASTORINA, V. CAVASINNI, S. CECCHINI, A. CERES, P. CHARVIS, P. CHAUCHOT, T. CHIARUSI, M. CIRCELLA, J-Y- COAIL, C. COLNARD, C. COMPERE, R. CONIGLIONE, N. COTTINI, P. COYLE, S. CUNEO, A-S. CUSSATLEGRAS, G. DAMY, R. VAN DANTZIG, G. DE BONIS, C. DE MARZO, R. DE VITA, I. DEKEYSER, E. DELAGNES, D. DENANS, A. DESCHAMPS, J.-X. DESSA, J-J. DESTELLE, B. DINKESPIELER, C. DISTEFANO, C. DONZAUD, J-F. DROGOU, F. DRUILLOLE, D. DURAND, J-P. ERNENWEIN, S. ESCOFFIER, E. FALCHINI, S. FAVARD, F. FEHR, F. FEINSTEIN, C. FIORELLO, V. FLAMINIO, K. FRATINI, J-L. FUDA, S. GALEOTTI, J-M. GALLONE, G. GIACOMELLI, N. GIRARD, C. GOJAK, PH. GORET, K. GRAF, G. HALLEWELL, M.N. HARAKEH, B. HARTMANN, A. HEIJBOER, E. HEINE, Y. HELLO, J.J. HERNANDEZ-REY, J. HOSSL, C. HOFFMAN, J. HOGENBIRK, J.R. HUBBARD, M. JAQUET, M. JASPERS, M. DE JONG, F. JOUVENOT, N. KALANTAR-NAYESTANAKI, A. KAPPES, T. KARG, U. KATZ, P. KELLER, J. P. KNEIB, E. KOK, H. KOK, P. KOOIJMAN, C. KOPPER, A. KOUCHNER, W. KRETSCHMER, A. KRUIJER, S. KUCH, P. LAGIER, R. LAHMANN, G. LAMANNA, P. LAMARE, G. LAMBARD, J-C. LANGUILLAT, H. LASCHINSKY, J. LAVALLE, Y. LE GUEN, H.LE PROVOST, A. LE VAN SUU, D. LEFEVRE, T. LEGOU, G. LELAIZANT, G. LIM, D.LO PRESTI, G. LOAEC, H. LOEHNER, S. LOUCATOS, F. LOUIS, F. LUCARELLI, V. LYASHUK, S. MANGANO, M. MARCELIN, A. MARGIOTTA, R. MASULLO, F. MAZEAS, A. MAZURE, R. MEGNA, M. MELISSAS, E. MIGNECO, M. MONGELLI, T. MONTARULI, M. MORGANTI, L. MOSCOSO, H. MOTZ, M. MUSUMECI, M. NAUMANN-GODO, C. NAUMANN, V. NIESS, T. NOBLE, C. OLIVETTO, R. OSTASCH, N. PALANQUE-DELABROUILLE, P. PAYRE, H. PEEK, A. PEREZ, C. PETTA, P. PIATTELLI, R. PILLET, J-P. PINEAU, J. POINSIGNON, V. POPA, T. PRADIER, C. RACCA, N. RANDAZZO, J. VAN RANDWIJK, D. REAL, M. REGNIER, B. VAN RENS, F. RETHORE, P. REWIERSMA, G. RICCOBENE, V. RIGAUD, M. RIPANI, V. ROCA, C. RODA, J.F. ROLIN, A. ROSTOVTSEV, J. ROUX, M. RUPPI, G.V. RUSSO, G. RUSYDI, F. SALESA, K. SALOMON, P. SAPIENZA, F. SCHMITT, J-P. SCHULLER, R. SHANIDZE, I. SOKALSKI, T. SPONA, M. SPURIO, G. VAN DER STEENHOVEN, T. STOLARCZYK, K. STREEB, L. SULAK, M. TAIUTI, C. TAMBURINI, C. TAO, L. TASCA, G. TERRENI, F. URBANO, P. VALDY, V. VALENTE, B. VALLAGE, G. VAUDAINE, G. VENEKAMP, B. VERLAAT, P. VERNIN, R. VAN WIJK, G. WIJNKER, G. WOBBE, E. DE WOLF, A-F. YAO, D. ZABOROV, H. ZACCONE, J.D. ZORNOZA, J. ZUNIGA, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANTARES, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), KVI - Center for Advanced Radiation Technology, and Research unit Nuclear & Hadron Physics
Subjects: leak detection, Nuclear and High Energy Physics, Acoustics, ELECTROMECHANICAL CABLES, Full scale, electromechanical cable, 01 natural sciences, Optics, Data acquisition, Data logger, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], optical time domain reflectometry, 14. Life underwater, Time domain, Electronics, sea deployment, 010306 general physics, Reflectometry, Instrumentation, Astroparticle physics, Physics, ANTARES, Hydrophone, antares, underwater neutrino telescope, 010308 nuclear & particles physics, business.industry, ANTARES, underwater neutrino telescope, leak detection, optical time domain reflectometry, electromechanical cable, sea deployment, UNDERWATER NEUTRINO TELESCOPES, 29.40.Ka, 29.90.+r, 92.10.Vz, business
Abstract: full-scale mechanical prototype line was deployed to a depth of 2500 m to test the leak tightness of the electronics containers and the pressure-resistant properties of an electromechanical cable under evaluation for use in the ANTARES deep-sea neutrino telescope. During a month-long immersion study, line parameter data were taken using miniature autonomous data loggers and shore-based optical time domain reflectometry. Details of the mechanical prototype line, the electromechanical cable and data acquisition are presented. Data taken during the immersion study revealed deficiencies in the pressure resistance of the electromechanical cable terminations at the entry points to the electronics containers. The improvements to the termination, which have been integrated into subsequent detection lines, are discussed. The line also allowed deep-sea acoustic measurements with a prototype hydrophone system. The technical setup of this system is described, and the first results of the data analysis are presented. (c) 2007 Elsevier B.V. All rights reserved.
Published: 2007

89. Studies on the Epidemiology of Equine Infection Anemia in Europe using the Gel-Precipitation Test1

Author: P. Goret and B. Toma
Subjects: medicine.medical_specialty, business.industry, Epidemiology, Medicine, Precipitation, business, Virology, Infection anemia
Published: 2015

90. Discovery of the two 'wings' of the Kookaburra complex in VHE γ-rays with HESS

Author: F. Aharonian, A. G. Akhperjanian, A. R. Bazer-Bachi, M. Beilicke, W. Benbow, D. Berge, K. Bernlöhr, C. Boisson, O. Bolz, V. Borrel, I. Braun, A. M. Brown, R. Bühler, I. Büsching, S. Carrigan, P. M. Chadwick, L.-M. Chounet, R. Cornils, L. Costamante, B. Degrange, H. J. Dickinson, A. Djannati-Ataï, L. O'C. Drury, G. Dubus, K. Egberts, D. Emmanoulopoulos, P. Espigat, F. Feinstein, E. Ferrero, A. Fiasson, G. Fontaine, S. Funk, M. Füßling, Y. A. Gallant, B. Giebels, J. F. Glicenstein, P. Goret, C. Hadjichristidis, D. Hauser, M. Hauser, G. Heinzelmann, G. Henri, G. Hermann, J. A. Hinton, A. Hoffmann, W. Hofmann, M. Holleran, D. Horns, A. Jacholkowska, O. C. de Jager, E. Kendziorra, B. Khélifi, Nu. Komin, A. Konopelko, K. Kosack, I. J. Latham, R. Le Gallou, A. Lemière, M. Lemoine-Goumard, T. Lohse, J. M. Martin, O. Martineau-Huynh, A. Marcowith, C. Masterson, G. Maurin, T. J. L. McComb, M. de Naurois, D. Nedbal, S. J. Nolan, A. Noutsos, K. J. Orford, J. L. Osborne, M. Ouchrif, M. Panter, G. Pelletier, S. Pita, G. Pühlhofer, M. Punch, B. C. Raubenheimer, M. Raue, S. M. Rayner, A. Reimer, O. Reimer, J. Ripken, L. Rob, L. Rolland, G. Rowell, V. Sahakian, A. Santangelo, L. Saugé, S. Schlenker, R. Schlickeiser, R. Schröder, U. Schwanke, S. Schwarzburg, A. Shalchi, H. Sol, D. Spangler, F. Spanier, R. Steenkamp, C. Stegmann, G. Superina, J.-P. Tavernet, R. Terrier, C. G. Théoret, M. Tluczykont, C. van Eldik, G. Vasileiadis, C. Venter, P. Vincent, H. J. Völk, S. J. Wagner, and M. Ward
Subjects: Point spread function, Physics, Photon, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Cosmic microwave background, Gamma ray, Astronomy and Astrophysics, Radius, Astrophysics, 01 natural sciences, Pulsar, 13. Climate action, Space and Planetary Science, 0103 physical sciences, Light emission, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Cherenkov radiation
Abstract: Aims. Search for Very High Energy gamma-ray emission in the Kookaburra complex through observations with the H.E.S.S. array. Methods. Stereoscopic imaging of Cherenkov light emission of the gamma-ray showers in the atmosphere is used for the reconstruction and selection of the events to search for gamma-ray signals. Their spectrum is derived by a forward-folding maximum likelihood fit. Results. Two extended gamma-ray sources with an angular (68%) radius of 3.3-3.4' are discovered at high (>13sigma) statistical significance: HESS J1420-607 and HESS J1418-609. They exhibit a flux above 1 TeV of (2.97+/-0.18stat +/-0.60sys)x10-12 and (2.17+/-0.17stat +/-0.43sys)x10-12 cm-2 s-1, respectively, and similar hard photon indices ~2.2. Multi-wavelength comparisons show spatial coincidence with the wings of the Kookaburra. Two pulsar wind nebulae candidates, K3/PSR J1420-6048 and the Rabbit, lie on the edge of the H.E.S.S. sources. Conclusions. The two new sources confirm the non-thermal nature of at least parts of the two radio wings which overlap with the gamma-ray emission and establish their connection with the two X-ray pulsar wind nebulae candidates. Given the large point spread function of EGRET, the unidentified source(s) 3EG J1420-6038/GeV J1417-6100 could possibly be related to either or both H.E.S.S. sources. The most likely explanation for the Very High Energy gamma-rays discovered by H.E.S.S. is inverse Compton emission of accelerated electrons on the Cosmic Microwave Background near the two candidate pulsar wind nebulae, K3/PSR J1420-6048 and the Rabbit. Two scenarios which could lead to the observed large (~10 pc) offset-nebula type morphologies are briefly discussed.
Published: 2006

91. Tailoring Empirical Antimicrobial Therapy in Subjects With Ventilator-Associated Pneumonia With a 10-Hour E-Test Approach.

Author: Boyer, Alexandre, Goret, Julien, Clouzeau, Benjamin, Romen, Antoine, Prevel, Renaud, Lhomme, Edouard, Vargas, Frédéric, Hilbert, Gilles, Bébéar, Cecile, Gruson, Didier, and M'Zali, Fatima
Subjects: ANTIBIOTICS, ACADEMIC medical centers, BRONCHOALVEOLAR lavage, CULTURE media (Biology), INTENSIVE care units, MICROBIAL sensitivity tests, DESCRIPTIVE statistics, VENTILATOR-associated pneumonia
Abstract: BACKGROUND: In a previous study of subjects suspected of having ventilator-associated pneumonia, a rapid susceptibility testing approach by using ETEST (BioMérieux) strips directly applied to bronchoalveolar lavage samples provided valuable information at hour 24. The primary objective of this study was to assess a new direct specimen testing by using an even more-rapid E-test approach (at hour 10), which could promote an early de-escalation of the antimicrobial therapy. METHODS: Twenty-eight subjects with ventilator-associated pneumonia admitted to a medical ICU were prospectively included. In parallel with standard routine methods, E-test strips were directly applied onto agar plates seeded with bronchoalveolar lavage samples and were analyzed after 10 h of incubation. E-test results were used to identify potential drug choices by simulating clinical decision making if the microscopy results had been available at the point of care. These choices were analyzed for concordance with the narrowest adequate antimicrobial therapy according to the Minimum Inhibitory Concentrations (MICs) provided by the reference method (ie, the laboratory routine diagnostic). RESULTS: At hour 10, direct specimen testing was readable in 18 of 28 bronchoalveolar lavage samples (64%). Total agreement between the 10-h direct specimen testing approach and the laboratory routine diagnostic approach was 90%, with a sensitivity of 83% and a specificity of 95%, with 8% major errors and 3% very major errors. The concordance between the 2 tests was very good (kappa = 0.79). If the 10-h E-test results were taken into account, then an early de-escalation strategy would have been possible in 10 of 18 cases (55%) at hour 10. CONCLUSIONS: This rapid susceptibility testing approach provided early (10 h) and valuable information that could lead to an early adjustment of empirical antimicrobial treatment in a ventilator-associated pneumonia setting. [ABSTRACT FROM AUTHOR]
Published: 2019
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92. La coopération entre allergologues et biologistes membres du réseau AllergoBioNet : le succès d'un modèle français.

Author: Mariotte, D., Beauvillain, C., Garnier, L., Goret, J., Nicaise-Roland, P., Rogeau, S., Sarrat, A., Vitte, J., and Pouessel, G.
Abstract: Le réseau AllergoBioNet est constitué de biologistes hospitaliers spécialistes des analyses contribuant au diagnostic et au suivi des maladies allergiques. Initialement constitué d'une dizaine de membres, il comporte actuellement soixante-dix-neuf biologistes français exerçant dans 29 CHU et 15 CH, ainsi qu'un biologiste belge. Parmi ces laboratoires, 10 ont été labellisés « laboratoires de biologie médicale de référence » (LBMR) du fait de leur expertise des explorations biologiques des maladies allergiques, des autres causes d'hypersensibilité, des pathologies mastocytaires et du complément. Les objectifs principaux des biologistes du réseau sont de tester et mettre en oeuvre des techniques robustes et fiables accréditées par le COFRAC, d'être un outil de formation médicale continue pour maintenir et actualiser les connaissances et compétences et de promouvoir des projets de recherche dont les résultats sont présentés dans les congrès nationaux et internationaux et sous forme d'articles publiés dans des revues spécialisées. Cet article est un appel auprès des biologistes hospitaliers à s'impliquer dans le domaine de l'allergologie via le réseau AllergoBioNet, mais aussi auprès des allergologues qui peuvent solliciter la collaboration de ces biologistes spécialisés pour répondre à leurs questions pratiques (conditions pré-analytiques, conservation des échantillons), de discuter des qualités analytiques des méthodes utilisées pour comprendre leurs limites techniques, de savoir où adresser le patient nécessitant une analyse très spécialisée et d'échanger autour de l'interprétation des résultats. Ce partenariat permet d'enrichir mutuellement les savoirs et les pratiques dans le but d'optimiser la prise en charge des patients. AllergoBioNet is a French association of clinical laboratory specialists of allergic and mast-cell-related diseases and their differential diagnoses. Its 79 members are working in clinical laboratories in 29 Universitary Hospitals and 15 General Hospitals in France and another one in Belgium. Ten of these laboratories have recently been certified as « laboratoires de biologie médicale de référence » (Reference Clinical Laboratories, LBMR) to valorize the expertise in hypersensitivity, mast-cell and complement laboratory investigations. The first mission of these laboratory professionals is to ensure that results are accurate and reliable. Thus, they deal with all the process of continuous quality improvement and are able to minimize errors of the sample's workflow (pre-analytic, analytic and post-analytic phases). Since years, they are certified by the French Organization for Quality (COFRAC). Moreover, they evaluate newer diagnostic tests, ensure continuous medical formation to actualize competences and knowledge, participate in research protocols and publish in national and international specialized reviews. The aims of this article are (1) to encourage all medical laboratory specialists working in the field of allergic diseases (diagnosis, monitoring patients and responses to therapy) to join the AllergoBioNet network; (2) to encourage physicians to collaborate with these laboratory professionals, so that they could answer to practical questions (ie: pre-analytical needs and conservation samples), receive updates for state-of-the-art laboratory methods and devices, refer patients needing highly specialized analyses and ensure interdisciplinary interpretation of clinical and laboratory results. This partnership should improve mutual competences and contribute to patient care. [ABSTRACT FROM AUTHOR]
Published: 2023
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93. Besoins en formations et informations en biologie de l'allergie : résultats de l'enquête SFA/ANAFORCAL.

Author: Sève, E., Goret, J., Court-Devilliers, S., Léquipé, J., and Klingebiel, C.
Abstract: La biologie est un outil incontournable dans le diagnostic et la prise en charge des patients allergiques. Pour compléter l'enquête auprès des jeunes allergologues publiée en 2022, le Groupe de travail biologie de l'Allergie (GTBA) en partenariat avec l'ANAFORCAL a réalisé une nouvelle enquête auprès des allergologues seniors afin d'évaluer leur formation en biologie de l'allergie et de connaître leurs attentes en termes d'information et formation continue. Au total, 1092 allergologues ont été contactés (avec des doublons entre les deux listes) et 219 ont répondu. Les allergologues s'estiment être bien formés. Plus de 70 % estiment avoir de bonnes connaissances sur le sujet et 94 % se forment régulièrement sur le sujet, en congrès tout d'abord, par la lecture d'articles scientifiques puis en réunions de formation locales. Sur cet échantillon, 69,4 % ont lu les recommandations sur la biologie de l'allergie publiées en 2021. Parmi ceux qui l'ont lu, 90 % en sont satisfaits. Cependant sur cet échantillon, 89 % n'ont jamais fait de stage dans un laboratoire d'immunoallergologie pendant leurs études. Cette enquête rapporte que 95 % des répondants veulent plus de formation et information, à propos des nouveaux allergènes moléculaires, puis de l'exploration des angiœdèmes bradykiniques, des puces à allergènes, à propos de la tryptase et enfin pour le suivi de l'immunothérapie allergénique (ITA). Ces thématiques sont souhaitées en formation DPC en ligne, au congrès francophone d'allergologie (CFA), ou sous forme de fiches sur le site de la Société française d'allergologie (SFA). Biology is an essential tool in the diagnosis and management of allergic patients. To complete the survey of young allergists published in 2022, the Allergy Biology Working Group (GTBA) in partnership with ANAFORCAL has carried out a new survey of senior allergists to assess their training in allergy biology and to know their expectations in terms of information and continuing education. A total of 1095 allergists were contacted (with duplicates between the two lists) and 219 responded. Allergists consider themselves to be well trained. More than 70% believe they have a good knowledge of the subject and 94% receive regular training on the subject, first at congresses, by reading scientific articles and then at local training meetings. Of this sample, 69.4% have read the recommendations on the biology of allergy published in 2021. Of those who have read it, 90% are satisfied with it. However, of this sample, 89% had never done an internship in an immuno-allergology laboratory during their studies. This survey reports that 95% of respondents want more training and information, about new Activé par Editorial Manager® and ProduXion Manager® about Aries Systems Corporation molecular allergens, then the exploration of bradykine angioedema, allergen chips, about tryptase and finally for the follow-up of immunotherapy allergen (ITA). These themes are desired in online CPD training, at the French-speaking congress of allergology (CFA), or in the form of sheets on the site of the French Society of Allergology (SFA). [ABSTRACT FROM AUTHOR]
Published: 2023
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94. Et si c’était un choc à la Bétadine® ?

Author: Barbier, O., Goret, J., Bordes, M., Pellerin, C., and Guez, S.
Abstract: Les principaux agents responsables des réactions anaphylactiques peropératoires sont bien connus. Cependant lorsque le bilan allergologique initial est négatif, des explorations complémentaires doivent être réalisées afin d’identifier un nouvel allergène potentiel comme les antiseptiques. Nous présentons un cas de choc anaphylactique peropératoire rapporté à la Bétadine®.
Published: 2021
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95. Dark Matter Searches with the ANTARES Neutrino Telescope

Author: A. Calzas, G. V. Russo, V. Roca-Blay, C. Ferdi, Elie Aslanides, E.-M. Clarke, A. Romeyer, H. Peek, C. Hoffmann, J.-F. Rollin, V. Lyashuk, Gisela Anton, T. Stolarczyk, M. Battaglieri, V. Niess, P. Keller, M. Ardid, F. Réthoré, F. Jouvenot, R. Bruyn, E. A. De Wolf, C. De Marzo, Antoine Kouchner, F. Mazéas, V. Bertin, J. Hoessl, E. Heine, P. Amram, J.-C. Languillat, Y. Le Guen, J.-L. Michel, E. Salusti, J. Jeffrey Carr, A. Usik, J.J. Destelle, De D.Zornoza, J. Boulesteix, A. Rostovtsev, A. Kruijer, M.C. Bouwhuis, S. Ferry, M. Billault, Alessia Capone, P.M. Kooijman, F. Burgio, F. Feinstein, D. Lo Presti, D. Zaborov, H. Le Provost, G. de Vries, J. Croquette, P. Piattelli, G. Venekamp, U. Katz, S. Loucatos, C. Racca, G. Giacomelli, J. E. McMillan, S. Saouter, P. Goret, I. Sokalski, Patrick Lamare, J.-F. Drougou, L. Laubier, V. Valente, J.J. Hernández-Rey, F. Louis, P. Coyle, Y. Benhammou, J.M. Gallone, G. Raia, T. Legou, A. Milovanovic, B. Dinkelspiler, S. Favard, E. V. Korolkova, M. Anghinolfi, Chantal Compère, L Lo Nigro, M. Romita, V. Popa, F. Sukowski, V. A. Kudryavtsev, A. Massol, M. Danilov, Philippe Charvis, Lester D.R. Thompson, S. Anvar, Yvonne Becherini, F. Bugeon, S. Cuneo, C. Petta, Fabrizio Ameli, H. Alleyne, J.J. Engelen, L. Caponetto, M. Ripani, E. Carmona, C. Olivetto, P. Vernin, F.E. Ardellier-Desages, S. L. Cartwright, Timo Karg, C. L. Naumann, B. Vallage, E. Migneco, Y. Sacquin, A. Bersani, K. Yearby, Anne Deschamps, J. Beltramelli, Alain Mazure, B. Hartmann, J. Hogenbirk, M. Godo, S. Cecchini, Sandra Zavatarelli, P.K.A. de Witt Huberts, M. Taiuti, E. Kok, G. Riccobene, R. van Wijk, T. Montaruli, Diego Real, M. Jaquet, J. Brunner, Yann Hello, O. Suvorova, Thierry Pradier, J.-P. Morel, G. Damy, D. Stubert, G. Herrouin, H. Zaccone, L. Moscoso, M. Circella, Annarita Margiotta, Maurizio Spurio, V. Zakharov, F. Cafagna, A.J. Heijboer, S. Karkar, W. Kretschmer, Alexander Kappes, J. J. Aubert, C. Millot, M. de Jong, P. Lagier, R. Blaes, P. Valdy, J.-P. Pineau, S. M. Bradbury, R. Masullo, Riccardo Papaleo, Roberto Bellotti, J. Zúñiga, M. Marcelin, J. P. Schuller, Mario Musumeci, A. Le Van Suu, R. De Vita, E. Vladimirsky, Gerardus Nooren, N. Randazzo, F. Druillole, D. Morgan, Elizabeth Winstanley, Jean Virieux, P. Payre, Gregory David Hallewell, H. J. Rose, Nathalie Palanque-Delabrouille, D. Festy, J. A. Aguilar, J.-L. Fuda, Van Rens, G. Vaudaine, R. van Dantzig, I. Varlamov, C. Maron, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Antares Collaboration
Subjects: Nuclear and High Energy Physics, Particle physics, WIMP, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, Bubble Chamber, neutrino telescopes, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 7. Clean energy, 0103 physical sciences, Bubble chamber, Dark Matter, 010306 general physics, 010303 astronomy & astrophysics, Cherenkov radiation, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Geyser detector, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Supersymmetry, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Neutrino detector, FISICA APLICADA, Weakly interacting massive particles, High Energy Physics::Experiment, Neutrino
Abstract: [EN] The MOSCAB experiment (Materia OSCura A Bolle) uses the Geyser technique for dark matter search. The results of the first 0.5 kg mass prototype detector using superheated C3F8 liquid were very encouraging, achieving a 5 keV nuclear recoil threshold with high insensitivity to gamma radiation. Additionally, the technique seems to be easily scalable to higher masses for both in terms of complexity and costs, resulting in a very competitive technique for direct dark matter search, especially for the spin dependent case. Here, we report as well in the construction and commissioning of the big detector of 40 kg at the Milano-Bicocca University. The detector, the calibration tests and the evaluation of the background will be presented. Once demonstrated the functionality of the detector, it will be operated at the Gran Sasso National Laboratory in 2015., We acknowledge the financial support of the Spanish Ministerio de Ciencia e Innovación (MICINN) and Ministerio de Economía y Competitividad (MINECO), Grants FPA2012-37528-C02-02, and Consolider MultiDark CSD2009-00064, and of the Generalitat Valenciana, Grants ACOMP/2014/153 and PrometeoII/2014/079.
Published: 2014

96. Radio to Gamma‐Ray Emission from Shell‐Type Supernova Remnants: Predictions from Nonlinear Shock Acceleration Models

Author: Stephen P. Reynolds, Isabelle Grenier, P. Goret, Matthew G. Baring, and Donald C. Ellison
Subjects: Physics, Photon, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics (astro-ph), Monte Carlo method, Bremsstrahlung, Gamma ray, FOS: Physical sciences, Astronomy and Astrophysics, Cosmic ray, Astrophysics, Electron, Supernova, Pion, Space and Planetary Science, Astrophysics::Galaxy Astrophysics
Abstract: Supernova remnants (SNRs) are widely believed to be the principal source of galactic cosmic rays. Such energetic particles can produce gamma-rays and lower energy photons via interactions with the ambient plasma. In this paper, we present results from a Monte Carlo simulation of non-linear shock structure and acceleration coupled with photon emission in shell-like SNRs. These non-linearities are a by-product of the dynamical influence of the accelerated cosmic rays on the shocked plasma and result in distributions of cosmic rays which deviate from pure power-laws. Such deviations are crucial to acceleration efficiency and spectral considerations, producing GeV/TeV intensity ratios that are quite different from test particle predictions. The Sedov scaling solution for SNR expansions is used to estimate important shock parameters for input into the Monte Carlo simulation. We calculate ion and electron distributions that spawn neutral pion decay, bremsstrahlung, inverse Compton, and synchrotron emission, yielding complete photon spectra from radio frequencies to gamma-ray energies. The cessation of acceleration caused by the spatial and temporal limitations of the expanding SNR shell in moderately dense interstellar regions can yield spectral cutoffs in the TeV energy range; these are consistent with Whipple's TeV upper limits on unidentified EGRET sources. Supernova remnants in lower density environments generate higher energy cosmic rays that produce predominantly inverse Compton emission at super-TeV energies; such sources will generally be gamma-ray dim at GeV energies., Comment: 62 pages, AASTeX format, including 1 table and 11 figures, accepted for publication in The Astrophysical Journal (Vol 513, March 1, 1999)
Published: 1999

97. First results of the Instrumentation Line for the deep-sea ANTARES neutrino telescope

Author: Philippe Charvis, R. De Vita, C. Kopper, B. van Rens, A. F. Yao, E. Castorina, S. Cecchini, G. Lim, E. A. De Wolf, E. Barbarito, V. A. Kudryavtsev, C. De Marzo, Corinne Donzaud, J. P. Schuller, C. Racca, F. Ameli, J. Beltramelli, V. Roca, J.-C. Languillat, P. Piattelli, P. Valdy, R. Bruijn, Annarita Margiotta, K. Streeb, S. Cuneo, W. Kretschmer, R. Ostasch, M. de Jong, G. Damy, Teresa Montaruli, M. Jaspers, J. E. Mcmillan, G. V. Russo, J.A. Aguilar, Gregory David Hallewell, F. Druillole, A. Capone, Nathalie Palanque-Delabrouille, M. Mongelli, S. Favard, N. de Botton, Yann Hello, N. Cottini, P. Chauchot, E. Falchini, H. J. Rose, F. Lucarelli, J. F. Drogou, F. Rethore, M. Morganti, D. Lo Presti, S. Kuch, Christian Tamburini, J.J. Destelle, L. Caillat, C. Gojak, Eric Delagnes, V. Cavasinni, A. Rostovtsev, S. Loucatos, R. Masullo, M. Jaquet, M. Melissas, C. Petta, I. Sokalski, H. Laschinsky, Roberto Bellotti, N. Girard, Gisela Anton, T. Stolarczyk, D. Real, Maurizio Spurio, N. Kalantar-Nayestanaki, V. Lyashuk, M. Ruppi, F. Feinstein, Rosario Megna, D. Stubert, M. Ripani, J. Zúñiga, H. Peek, J. Busto, J. J. Aubert, R. van Dantzig, J. Carr, P. Rewiersma, V. Rigaud, C. Olivetto, S. L. Cartwright, M.C. Bouwhuis, J.-P. Pineau, U. F. Katz, A.J. Heijboer, Ivan Dekeyser, P. Coyle, J. van Randwijk, K. Graf, P. Sapienza, H. Zaccone, F. Salesa, V. Flaminio, Alexander Kappes, Ch. Naumann, M. Naumann-Godo, M. Battaglieri, F. Jouvenot, A. Albert, D. Zaborov, A. Ceres, R. Shadnize, M. Billault, B. Vallage, A. S. Cussatlegras, P. Keller, P. Goret, C. Roda, A. Levan Suu, P. Payre, A. Milovanovic, G. de Vries, Anne Deschamps, M. Romita, Y. Leguen, R. Coniglione, G. van der Steenhoven, Alain Mazure, J. Hogenbirk, D. Festy, L. Moscoso, B. Dinkespieler, D. Denans, T. Spona, M. Marcelin, E. Korolkova, C. Hoffman, R. Lahmann, G. Terreni, H. Kok, F. Mazéas, C. Fiorello, S. M. Bradbury, J.R. Hubbard, Patrick Lamare, R. van Wijk, Juan José Hernández-Rey, M. Circella, H. Le Provost, J.M. Gallone, J. Roux, S. Anvar, Charling Tao, F. Louis, S. Basa, D. Lachartre, Yvonne Becherini, G. F. Burgio, J. Poinsignon, Jean-Francois Rolin, V. Bertin, B. Verlaat, Lester D.R. Thompson, Elie Aslanides, A. Kruijer, G. Wobbe, P. K. A. de Witt-Huberts, S. Ferry, A. Calzas, L. Caponetto, S. Galeotti, N. Randazzo, G. Venekamp, M. Musumeci, H. Lafoux, Jean-Pierre Ernenwein, E. Migneco, T. Karg, C. Colnard, P. Vernin, V. Valente, Mohsen Harakeh, B. Hartmann, F. Dessages-Ardellier, P. Lagier, M. Taiuti, P. Kooijman, T. Legou, F. Schmitt, G. Giacomelli, G. Lamanna, J. Hossl, Stephanie Escoffier, Giorgio Riccobene, J.D. Zornoza, Antoine Kouchner, V. Niess, T. Pradier, E. Carmona, Dominique Durand, D. Castel, M. Anghinolfi, C. Distefano, S. Karkar, K. Salomon, R. Blaes, E. Heine, T. Chiarusi, A. Bigi, Lawrence Sulak, Jürgen Brunner, F. Cafagna, Chantal Compère, H. Löhner, L Lo Nigro, V. Popa, Groupe de Recherche en Physique des Hautes Energies (GRPHE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut Universitaire de Technologie de Colmar, Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Géoazur (GEOAZUR 6526), Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer - Brest (IFREMER Centre de Bretagne), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Centre d'océanologie de Marseille (COM), Université de la Méditerranée - Aix-Marseille 2-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), IFREMER - Centre de Toulon/La Seyne Sur Mer (IFREMER), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), ANTARES, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer - Brest (IFREMER), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de la Méditerranée - Aix-Marseille 2, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), J.A. AGUILAR, A. ALBERT, F. AMELI, P. AMRAM, M. ANGHINOLFI, G. ANTON, S. ANVAR, F.E. ARDELLIER-DESAGES, E. ASLANIDES, J.J. AUBERT, D. BAILEY, S. BASA, M. BATTAGLIERI, Y. BECHERINI, R. BELLOTTI, J. BELTRAMELLI, V. BERTIN, M. BILLAULT, R. BLAES, F. BLANC, N. DE BOTTON, J. BOULESTEIX, M.C. BOUWHUIS, C.B. BROOKS, S.M. BRADBURY, R. BRUIJN, J. BRUNNER, G.F. BURGIO, F. CAFAGNA, A. CALZAS, A. CAPONE, L. CAPONETTO, E. CARMONA, J. CARR, S.L. CARTWRIGHT, E. CASTORINA, V. CAVASINNI, S. CECCHINI, P. CHARVIS, M. CIRCELLA, C. COLNARD, C. COMPERE, R. CONIGLIONE, S. COOPER, P. COYLE, S. CUNEO, G. DAMY, R. VAN DANTZIG, A. DESCHAMPS, C. DE MARZO, D. DENANS, J.J. DESTELLE, R. DE VITA, B. DINKELSPILER, C. DISTEFANO, J.F. DROGOU, F. DRUILLOLE, J. ENGELEN, J.P. ERNENWEIN, E. FALCHINI, S. FAVARD, F. FEINSTEIN, S. FERRY, D. FESTY, V. FLAMINIO, J. FOPMA, J.L. FUDA, J.M. GALLONE, G. GIACOMELLI, N. GIRARD, P. GORET, K. GRAF, G. HALLEWELL, B. HARTMANN, A. HEIJBOER, Y. HELLO, J.J. HERNANDEZ-REY, G. HERROUIN, J. HÖßL, C. HOFFMANN, J.R. HUBBARD, M. JAQUET, M. DE JONG, F. JOUVENOT, A. KAPPES, T. KARG, S. KARKAR, M. KAROLAK, U. KATZ, P. KELLER, P. KOOIJMAN, E.V. KOROLKOVA, A. KOUCHNER, W. KRETSCHMER, S. KUCH, V.A. KUDRYAVTSEV, H. LAFOUX, P. LAGIER, R. LAHMANN, P. LAMARE, J.C. LANGUILLAT, H. LASCHINSKY, L. LAUBIER, T. LEGOU, Y. LE GUEN, H. LE PROVOST, A. LE VAN SUU, L. LO NIGRO, D. LO PRESTI, S. LOUCATOS, F. LOUIS, V. LYASHUK, M. MARCELIN, A. MARGIOTTA, C. MARON, A. MASSOL, R. MASULLO, F. MAZÉAS, A. MAZURE, J.E. MCMILLAN, E. MIGNECO, C. MILLOT, A. MILOVANOVIC, F. MONTANET, T. MONTARULI, J.-P. MOREL, M. MORGANTI, L. MOSCOSO, M. MUSUMECI, C. NAUMANN, M. NAUMANN-GODO, E. NEZRI, V. NIESS, G.J. NOOREN, P. OGDEN, C. OLIVETTO, N. PALANQUE-DELABROUILLE, R. PAPALEO, P. PAYRE, C. PETTA, P. PIATTELLI, J.P. PINEAU, J. POINSIGNON, V. POPA, R. POTHEAU, T. PRADIER, C. RACCA, G. RAIA, N. RANDAZZO, D. REAL, B.A.P. VAN RENS, F. RÉTHORÉ, G. RICCOBENE, V. RIGAUD, M. RIPANI, V. ROCA-BLAY, J.F. ROLIN, M. ROMITA, H.J. ROSE, A. ROSTOVTSEV, M. RUPPI, G.V. RUSSO, Y. SACQUIN, F. SALESA, K. SALOMON, S. SAOUTER, P. SAPIENZA, R. SHANIDZE, J.-P. SCHULLER, W. SCHUSTER, I. SOKALSKI, M. SPURIO, T. STOLARCZYK, D. STUBERT, M. TAIUTI, L.F. THOMPSON, S. TILAV, P. VALDY, V. VALENTE, B. VALLAGE, P. VERNIN, J. VIRIEUX, G. DE VRIES, P. DE WITT HUBERTS, E. DE WOLF, D. ZABOROV, H. ZACCONE, V. ZAKHAROV, J.D. ZORNOZA, J. ZUÑIGA, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), and KVI - Center for Advanced Radiation Technology
Subjects: Photomultiplier, neutrino astronomy, photon detection, underwater detector, Positioning system, Instrumentation, Astrophysics::High Energy Astrophysical Phenomena, Neutrino astronomy, Underwater detector, Photon detection, FOS: Physical sciences, Astrophysics, 01 natural sciences, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], 0103 physical sciences, Calibration, Angular resolution, 010306 general physics, Remote sensing, Astroparticle physics, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Detector, Astrophysics (astro-ph), Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, SITE, Astronomy and Astrophysics, LIGHT, PHOTON DETECTION, NEUTRINO ASTRONOMY, Física nuclear, UNDERWATER DETECTOR, Neutrino astronomy
Abstract: In 2005, the ANTARES Collaboration deployed and operated at a depth of 2500 m a so-called Mini Instrumentation Line equipped with Optical Modules (MILOM) at the ANTARES site. The various data acquired during the continuous operation from April to December 2005 of the MILOM confirm the satisfactory performance of the Optical Modules, their front-end electronics and readout system, as well as the calibration devices of the detector. The in-situ measurement of the Optical Module time response yields a resolution better than 0.5 ns. The performance of the acoustic positioning system, which enables the spatial reconstruction of the ANTARES detector with a precision of about 10 cm, is verified. These results demonstrate that with the full ANTARES neutrino telescope the design angular resolution of better than $0.3^\circ$ can be realistically achieved., Comment: 18 pages, 12 figures, submitted to Astroparticle Physics
Published: 2006

98. SAM: A new GHz sampling ASIC for the H.E.S.S.-II front-end electronics

Author: P. Nayman, E. Delagnes, F. Toussenel, Yavuz Degerli, P. Goret, Pascal Vincent, Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), P. Bourgeois, H. El Mamouni, P. Goret, P. LeDû, O. Limousin, P. Nédélec, V. Puill and J.C. Vanel, and HESS
Subjects: Nuclear and High Energy Physics, 01 natural sciences, Sampler, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Application-specific integrated circuit, Sampling (signal processing), 0103 physical sciences, Electronics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, 010306 general physics, Instrumentation, Electronic circuit, Analogue to digital conversion, Readout, Physics, 95.55.Ka, 85.40.−e, 84.30.−r, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, business.industry, Dynamic range, ASIC, Bandwidth (signal processing), Electrical engineering, Chip, business, Communication channel, Analogue memory
Abstract: The H.E.S.S.-II front-end electronics, with its 20 GeV energy threshold, will require a much higher acquisition rate capability and a larger dynamic range than was relevant for H.E.S.S.-I. These constraints led to the development of a new ASIC, called SAM for Swift Analogue Memory, to replace the ARS used for H.E.S.S.-I. The SAM chip features 2 channels for the low and high gain outputs of a PMT, each channel having a depth of 256 analogue memory cells. The sampling frequency is adjustable from 0.7 up to 2 GS/s and the read-out time for one event is decreased from 275 down to 2.3 μs. The SAM input bandwidth and dynamic range are increased up to 300 MHz and more than 11 bits, respectively.
Published: 2005

99. Study of Large Hemispherical Photomultiplier Tubes for the ANTARES Neutrino Telescope

Author: F. Salesa, F. Ameli, I. Sokalski, Jean Virieux, T. Legou, Robert Lahmann, J. Carr, G.V. Russo, Lester D.R. Thompson, Nathalie Palanque-Delabrouille, F. Montanet, C. Hoffmann, A. Calzas, J. Fopma, V. Roca-Blay, E. Falchini, A. Le Van Suu, E. Nezri, L. Caponetto, W. Kretschmer, D. Lo Presti, R. Coniglione, R. De Vita, V. Rigaud, F. Réthoré, C. Racca, S. Saouter, P. Goret, R. Blaes, S. L. Cartwright, J. Poinsignon, L. Moscoso, J-J. Aubert, E. Castorina, M. Jaquet, U. F. Katz, Jean-Luc Fuda, V. Bertin, Elie Aslanides, Giorgio Riccobene, M. Anghinolfi, A. Mazure, C. Olivetto, C.B. Brooks, H. Lafoux, Timo Karg, L. Laubier, D. Denans, Vincenzo Cavasinni, V. A. Kudryavtsev, C. Distefano, Yann Hello, V. Valente, S. Favard, P.M. Kooijman, P. A. Ogden, R. Potheau, R. van Dantzig, G. Giacomelli, V. Lyashuk, J.D. Zornoza, Nunzio Randazzo, M. Battaglieri, S. Loucatos, J.-P. Ernenwein, R. Bruijn, F.E. Ardellier-Desages, E. Migneco, Rezo Shanidze, G. Damy, M. Taiuti, T. Pradier, C. De Marzo, P. Coyle, S. Cuneo, G. de Vries, M. Karolak, Paolo Sapienza, F. Jouvenot, V. Niess, F. Mazéas, S. Kuch, F. Blanc, S. Basa, A. Albert, H. J. Rose, Teresa Montaruli, P.K.A. de Witt Huberts, G. F. Burgio, G. Raia, Y. Sacquin, Jürgen Brunner, A. Rostovtsev, M. Ripani, Jean-Francois Rolin, E. Carmona, M.C. Bouwhuis, J.-C. Languillat, D. S. Bailey, J.-J. Destelle, J. Hößl, F. Louis, P. Lamare, M. Naumann-Godo, S. Tilav, S. Ferry, E. A. De Wolf, Juanan Aguilar, Philippe Charvis, P. Valdy, E. V. Korolkova, Alexander Kappes, B. van Rens, C. Maron, S. Cecchini, H. Le Provost, Juan José Hernández-Rey, P. Keller, F. Feinstein, Y. Le Guen, S. Karkar, Antonio Capone, N. Girard, Maurizio Spurio, A.J. Heijboer, J.J. Engelen, Kay Graf, F. Cafagna, Chantal Compère, M. Ruppi, Roberto Bellotti, V. Flaminio, Antoine Kouchner, M. Morganti, L Lo Nigro, B. Vallage, B. Dinkelspiler, J. Zúñiga, Jean-Pierre Morel, M. Romita, V. Popa, B. Hartmann, D. Festy, J. E. McMillan, S. M. Bradbury, R. Masullo, J. Beltramelli, Riccardo Papaleo, C. Petta, Wolfgang Schuster, H. Laschinsky, P. Amram, J. Boulesteix, J. F. Drogou, Annarita Margiotta, Gisela Anton, T. Stolarczyk, A. Milovanovic, D. Stubert, G.D. Hallewell, J. P. Schuller, P. Payre, K. Salomon, C. Millot, J.-P. Pineau, C. Naumann, P. Piattelli, D. Zaborov, Anne Deschamps, A. Massol, M. Marcelin, M. Billault, V. Zakharov, J.R. Hubbard, Diego Real, J.M. Gallone, Susan Cooper, S. Anvar, Yvonne Becherini, M. de Jong, F. Druillole, N. de Botton, G. Herrouin, H. Zaccone, C. Colnard, Mario Musumeci, Gerardus Nooren, P. Vernin, M. Circella, P. Lagier, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Géoazur (GEOAZUR 6526), Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANTARES, J.A. AGUILAR, A. ALBERT, F. AMELI, P. AMRAM, M. ANGHINOLFI, G. ANTON, S. ANVAR, F.E. ARDELLIER-DESAGES, E. ASLANIDES, J.J. AUBERT, D. BAILEY, S. BASA, M. BATTAGLIERI, Y. BECHERINI, R. BELLOTTI, J. BELTRAMELLI, V. BERTIN, M. BILLAULT, R. BLAES, F. BLANC, N. DE BOTTON, J. BOULESTEIX, M.C. BOUWHUIS, C.B. BROOKS, S.M. BRADBURY, R. BRUIJN, J. BRUNNER, G.F. BURGIO, F. CAFAGNA, A. CALZAS, A. CAPONE, L. CAPONETTO, E. CARMONA, J. CARR, S.L. CARTWRIGHT, E. CASTORINA, V. CAVASINNI, S. CECCHINI, P. CHARVIS, M. CIRCELLA, C. COLNARD, C. COMPERE, R. CONIGLIONE, S. COOPER, P. COYLE, S. CUNEO, G. DAMY, R. VAN DANTZIG, A. DESCHAMPS, C. DE MARZO, D. DENANS, J.J. DESTELLE, R. DE VITA, B. DINKELSPILER, C. DISTEFANO, J.F. DROGOU, F. DRUILLOLE, J. ENGELEN, J.P. ERNENWEIN, E. FALCHINI, S. FAVARD, F. FEINSTEIN, S. FERRY, D. FESTY, V. FLAMINIO, J. FOPMA, J.L. FUDA, J.M. GALLONE, G. GIACOMELLI, N. GIRARD, P. GORET, K. GRAF, G. HALLEWELL, B. HARTMANN, A. HEIJBOER, Y. HELLO, J.J. HERNANDEZ-REY, G. HERROUIN, J. HÖßL, C. HOFFMANN, J.R. HUBBARD, M. JAQUET, M. DE JONG, F. JOUVENOT, A. KAPPES, T. KARG, S. KARKAR, M. KAROLAK, U. KATZ, P. KELLER, P. KOOIJMAN, E.V. KOROLKOVA, A. KOUCHNER, W. KRETSCHMER, S. KUCH, V.A. KUDRYAVTSEV, H. LAFOUX, P. LAGIER, R. LAHMANN, P. LAMARE, J.C. LANGUILLAT, H. LASCHINSKY, L. LAUBIER, T. LEGOU, Y. LE GUEN, H. LE PROVOST, A. LE VAN SUU, L. LO NIGRO, D. LO PRESTI, S. LOUCATOS, F. LOUIS, V. LYASHUK, M. MARCELIN, A. MARGIOTTA, C. MARON, A. MASSOL, R. MASULLO, F. MAZÉAS, A. MAZURE, J.E. MCMILLAN, E. MIGNECO, C. MILLOT, A. MILOVANOVIC, F. MONTANET, T. MONTARULI, J.-P. MOREL, M. MORGANTI, L. MOSCOSO, M. MUSUMECI, C. NAUMANN, M. NAUMANN-GODO, E. NEZRI, V. NIESS, G.J. NOOREN, P. OGDEN, C. OLIVETTO, N. PALANQUE-DELABROUILLE, R. PAPALEO, P. PAYRE, C. PETTA, P. PIATTELLI, J.P. PINEAU, J. POINSIGNON, V. POPA, R. POTHEAU, T. PRADIER, C. RACCA, G. RAIA, N. RANDAZZO, D. REAL, B.A.P. VAN RENS, F. RÉTHORÉ, G. RICCOBENE, V. RIGAUD, M. RIPANI, V. ROCA-BLAY, J.F. ROLIN, M. ROMITA, H.J. ROSE, A. ROSTOVTSEV, M. RUPPI, G.V. RUSSO, Y. SACQUIN, F. SALESA, K. SALOMON, S. SAOUTER, P. SAPIENZA, R. SHANIDZE, J.-P. SCHULLER, W. SCHUSTER, I. SOKALSKI, M. SPURIO, T. STOLARCZYK, D. STUBERT, M. TAIUTI, L.F. THOMPSON, S. TILAV, P. VALDY, V. VALENTE, B. VALLAGE, P. VERNIN, J. VIRIEUX, G. DE VRIES, P. DE WITT HUBERTS, E. DE WOLF, D. ZABOROV, H. ZACCONE, V. ZAKHAROV, J.D. ZORNOZA, J. ZUÑIGA, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)
Subjects: Nuclear and High Energy Physics, Photomultiplier, Physics - Instrumentation and Detectors, Neutrino detection, Neutrino telescope, FOS: Physical sciences, 01 natural sciences, large area photosensor, hemispherical photomultiplier, neutrino detection, Nuclear physics, Optics, Intensive Phase, 0103 physical sciences, 14. Life underwater, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation, Astroparticle physics, Physics, 010308 nuclear & particles physics, business.industry, Hemispherical photomultiplier, Instrumentation and Detectors (physics.ins-det), Large area photosensor, Glass spheres, Neutrino detector, 95.55.Vj, 85.60.Ha, Física nuclear, business, hemispherical photomultiplier, large area photosensor, neutrino detection
Abstract: The ANTARES neutrino telescope, to be immersed depth in the Mediterranean Sea, will consist of a 3 dimensional matrix of 900 large area photomultiplier tubes housed in pressure resistant glass spheres. The selection of the optimal photomultiplier was a critical step for the project and required an intensive phase of tests and developments carried out in close collaboration with the main manufacturers worldwide. This paper provides an overview of the tests performed by the collaboration and describes in detail the features of the PMT chosen for ANTARES., Comment: 21 pages, 10 figures. To be published in Nuclear Inst. and Methods in Physics Research, A
Published: 2005

100. Recommandations d'AllergoBioNet pour les critères de performance des dosages d'IgE et de la tryptase.

Author: Goret, Julien, Couderc, Rémy, Garnier, Lorna, Grenier, Angélique, Vitte, Joana, Sarrat, Anne, and AllergoBioNet, pour le réseau
Abstract: La vérification d'une méthode de dosage selon la norme NF/EN/ISO 15189 requiert l'analyse des performances de la technique (répétabilité, fidélité intermédiaire, exactitude et incertitude de mesure) avant toute utilisation en routine. Les coefficients de variation (CV) des résultats de précision intra-essai et inter-essais obtenus doivent être comparés à ceux des pairs et à ceux qui pratiquent ces mêmes dosages quelle que soit la technique. En l'absence de publications nationales ou internationales pour les IgE spécifiques et la tryptase, le réseau des biologistes des centres hospitaliers AllergoBioNet a analysé les résultats fournis par 24 centres pour proposer des limites acceptables des critères de performance pour le dosage des IgE totales et spécifiques et de la tryptase. Checking a dosing method according to NF/EN/ISO 15189 standard requires analysis of the performance of the technique (repeatability, intermediate fidelity, accuracy and measurement uncertainty) before routine use and follow-up annually. The coefficients of variation (CV) of the intra-assay and inter-assays accuracy results obtained must be compared with those of peers and those who perform the same determination regardless of the technique. In the absence of national or international guidelines for monitoring the performance of specific IgE and tryptase assay, the French network of hospital laboratories AllergoBioNet analysed the results provided by 24 centers and propose recommendations for total IgE, specific IgE and tryptase assays. [ABSTRACT FROM AUTHOR]
Published: 2020
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