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538 results on '"Ozelo, Margareth"'

51. Chronic pain in patients with hemophilia: Influence of kinesiophobia and catastrophizing thoughts.

Author

Feldberg, Glenda, Ricciardi, Janaína B.S., Zorzi, Alessandro R., Colella, Marina P., Yamaguti‐Hayakawa, Gabriela G., and Ozelo, Margareth C.

Subjects
CHRONIC pain, KNEE pain, HEMOPHILIACS, ANTERIOR cruciate ligament surgery
Abstract

To define the presence or absence of chronic pain, patients were asked based on the definition of the International Association for the Study of Pain (IASP),[4] which determines "chronic pain" as recurrent or persistent pain in the last 3 months. Keywords: catastrophizing thoughts; chronic pain; haemophilia; kinesiophobia; pain EN catastrophizing thoughts chronic pain haemophilia kinesiophobia pain 386 389 4 01/27/23 20230101 NES 230101 To the Editor, People with haemophilia (PWH) usually begin to suffer pain at a young age. Regarding chronic pain, 46 patients (64.8%) were placed in the chronic pain group, and 25 patients (35.2%) were allocated to the non-chronic pain group. Patients with chronic pain had a higher median level in HJHS when compared to the patient group without pain ( I p i < .001). [Extracted from the article]

Published
2023
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55. Relationship between Endogenous, Transgene FVIII Expression and Bleeding Events Following Valoctocogene Roxaparvovec Gene Transfer for Severe Hemophilia A: A Post-Hoc Analysis of the GENEr8-1 Phase 3 Trial

Author

Pipe, Steven W, primary, Ozelo, Margareth C, additional, Kenet, Gili, additional, Reding, Mark T, additional, Mason, Jane, additional, Leavitt, Andrew D, additional, Madan, Bella, additional, Laffan, Michael, additional, Quon, Doris V., additional, von Drygalski, Annette, additional, Chou, Sheng-Chieh, additional, Shapiro, Susan, additional, Dunn, Amy L, additional, Wang, Michael, additional, Key, Nigel S, additional, Kaczmarek, Radoslaw, additional, Symington, Emily, additional, Lawal, Adebayo, additional, Mahajan, Reena, additional, Chavele, Konstantia-Maria, additional, Reddy, Divya B, additional, Yu, Hua, additional, Wong, Wing Yen, additional, Robinson, Tara M, additional, and Kim, Benjamin, additional

Published
2021
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56. Acquired Hemophilia a Relapse Is Related to Th2 Response, and Increased Expression of B-Cell Activating Factor (BAFF)

Author

Frade-Guanaes, Jessica O, primary, Racanelli, Ana P, additional, Siqueira, Lucia H, additional, Costa-Lima, Carolina, additional, Medina, Samuel S, additional, Foschi, Nivia M, additional, Colella, Marina P, additional, Montalvão, Silmara A L, additional, Yamaguti-Hayakawa, Gabriela G, additional, and Ozelo, Margareth C, additional

Published
2021
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57. von Willebrand disease: proposing definitions for future research

Author

Connell, Nathan T., James, Paula D., Brignardello-Petersen, Romina, Abdul-Kadir, Rezan, Ameer, Barbara, Arapshian, Alice, Couper, Susie, Di Paola, Jorge, Eikenboom, Jeroen, Giraud, Nicolas, Grow, Jean M., Haberichter, Sandra, Jacobs-Pratt, Vicki, Konkle, Barbara A., Kouides, Peter, Laffan, Michael, Lavin, Michelle, Leebeek, Frank W.G., McLintock, Claire, McRae, Simon, Montgomery, Robert, O'Brien, Sarah H., O'Donnell, James S., Ozelo, Margareth C., Scappe, Nikole, Sidonio, Robert, Jr, Tosetto, Alberto, Weyand, Angela C., Kalot, Mohamad A., Husainat, Nedaa, Mustafa, Reem A., and Flood, Veronica H.

Published
2021
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58. Long-acting recombinant factor IX Fc fusion protein (rFIXFc) for perioperative management of subjects with haemophilia B in the phase 3 B-LONG study

Author

Powell, Jerry S., Apte, Shashikant, Chambost, Hervé, Hermans, Cedric, Jackson, Shannon, Josephson, Neil C., Mahlangu, Johnny N., Ozelo, Margareth C., Peerlinck, Kathelijne, Pasi, John, Perry, David, Ragni, Margaret V., Wang, Xuefeng, Jiang, Haiyan, Li, Shuanglian, Cristiano, Lynda M., Innes, Alison, Nugent, Karen, Brennan, Aoife, Luk, Alvin, Allen, Geoffrey, Pierce, Glenn F., and Robinson, Brian

Published
2015
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61. Addressing unmet needs in rare bleeding disorders: selected poster extracts of recent research in hemophilia A and von Willebrand disease presented at the 14th Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD) (Feb 3–5, 2021; virtual congress)

Author

Allen, Geoffrey, primary, Du, Ping, additional, Khair, Kate, additional, Lee, Hye-Youn, additional, Ozelo, Margareth C., additional, Berthoz, Françoise Truong, additional, and Windyga, Jerzy, additional

Published
2021
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62. Knee radiosynovectomy with Sm-153-hydroxyapatite compared to Y-90-hydroxyapatite : initial results of a prospective trial

Author

Santos, Allan de Oliveira, 1971, Ricciardi, Janaina Bosso da Silva, Pagnano, Rodrigo Gonçalves, 1967, Pereira, Luís Fernando Moreno, 1987, Sakuma, Emerson Taro Inoue, 1977, Brunetto, Sérgio Querino, 1955, Takahashi, Maria Emilia Seren, 1985, Brunetto, Edna Marcia Rodrigues, Zulli, Roberto, Ozelo, Margareth Castro, 1970, Etchebehere, Elba Cristina Sa de Camargo, 1967, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Hidroxiapatita, Samarium, Joelho, Y-90-hydroxyapatite, Hemarthrosis, Samário, Sm-153-hydroxyapatite, Artigo original, Knee, Radiosynovectomy, Samarium-153, Hydroxyapatite
Abstract

Agradecimentos: We thank the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP # 2013/05255-7) for partial financing of this investigation. We also thank Efrain Perini (PhD) and Jair Mengatti (PhD) from the Radiopharmacy Center of the Nuclear and Energy Research Institute (IPEN/CNEN), São Paulo, Brazil Abstract: Introduction Radiosynovectomy (RS) with Y-90-hydroxyapatite (Y-90-HyA) aims to control knee hemarthrosis in hemophiliac patients to prevent secondary arthropathy. However, knee RS using Sm-153-hydroxyapatite (Sm-153-HyA) is considered less suitable due to the lower average soft tissue range and energy of Sm-153 for large joints, such as the knees. Purpose The objective of this investigation was to assess the efficacy and safety of knee RS with Sm-153-HyA, compared to Y-90-HyA. Methods Forty patients were prospectively assigned to undergo knee RS with Sm-153-HyA (n = 19) or with Y-90-HyA (n = 21). The frequency of hemarthrosis episodes before and after treatment were compared. Results After six months of knee RS, Sm-153-HyA and Y-90-HyA promoted a similar reduction of hemarthrosis episodes (50% and 66.7%, respectively). However, after 12 months of knee RS, the reduction of hemarthrosis episodes was significantly (p = 0.037) higher using Sm-153-HyA (87.5%) compared to Y-90-HyA (50.0%). This discrepancy was more pronounced (p = 0.002) for Sm-153-HyA compared to Y-90-HyA in adults/adolescents. Conclusion Knee radiosynovectomy with Sm-153-HyA is safe, reduces hemarthrosis episodes after 12 months of treatments, especially in adults/adolescents and even with grades III/IV arthropathy, similar to Y-90-HyA. Y-90-HyA seems to promote better hemarthrosis control in small children FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP Fechado

Published
2021

66. Phase 3 Study of Recombinant Factor IX Fc Fusion Protein in Hemophilia B

Author

Powell, Jerry S., Pasi, John K., Ragni, Margaret V., Ozelo, Margareth C., Valentino, Leonard A., Mahlangu, Johnny N., Josephson, Neil C., Perry, David, Manco-Johnson, Marilyn J., Apte, Shashikant, Baker, Ross I., Chan, Godfrey C., Novitzky, Nicolas, Wong, Raymond S., Krassova, Snejana, Allen, Geoffrey, Jiang, Haiyan, Innes, Alison, Li, Shuanglian, Cristiano, Lynda M., Goyal, Jaya, Sommer, Jurg M., Dumont, Jennifer A., Nugent, Karen, Vigliani, Gloria, Brennan, Aoife, Luk, Alvin, and Pierce, Glenn F.

Published
2013
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67. Effectiveness, safety, and health-related quality of life outcomes in patients with hemophilia A receiving antihemophilic factor (recombinant) in a real-world setting: results of a 6-year interim analysis of the AHEAD International study

Author

Oldenburg, Johannes, Ozelo, Margareth C., Klamroth, Robert, Guillet, Benoît, Khair, Kate, Tsakiris, Dimitrios A., Botha, Jaco, Fernandez-Martinez, Alejandro, Tang, Leilei, Santagostino, Elena, Bonn Universitat Clinique, Inst Expt Hematol and Transfus Med, Germany, University Hospital Bonn, Universidade Estadual de Campinas = University of Campinas (UNICAMP), Vivantes Klinikum Friedrichshain, Dept Internal Med Vasc Med and Haemostaseol, Germany, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU London, CHU Basel, CHU Milan, University of Campinas [Campinas] (UNICAMP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

70. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Author

Manno, Catherine S, Pierce, Glenn F, Arruda, Valder R, Glader, Bertil, Ragni, Margaret, Rasko, John J E, Ozelo, Margareth C, Hoots, Keith, Blatt, Philip, Konkle, Barbara, Dake, Michael, Kaye, Robin, Razavi, Mahmood, Zajko, Albert, Zehnder, James, Rustagi, Pradip, Nakai, Hiroyuki, Chew, Amy, Leonard, Debra, Wright, J Fraser, Lessard, Ruth R, Sommer, Jurg M, Tigges, Michael, Sabatino, Denise, Luk, Alvin, Jiang, Haiyan, Mingozzi, Federico, Couto, Linda, Ertl, Hildegund C, High, Katherine A, and Kay, Mark A

Abstract

Author(s): Catherine S Manno [1, 2, 15]; Glenn F Pierce [3, 15]; Valder R Arruda [1, 2, 15]; Bertil Glader [4, 15]; Margaret Ragni [5]; John J E Rasko [6]; [...]

Published
2006
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74. Effectiveness and Safety Outcomes in Patients with Hemophilia a Receiving Antihemophilic Factor (Recombinant) for at Least 5 Years in a Real-World Setting: 6-Year Interim Analysis of the Ahead International and German Studies

Author

Tsakiris, Dimitrios A., primary, Oldenburg, Johannes, additional, Klamroth, Robert, additional, Guillet, Benoît, additional, Khair, Kate, additional, Huth-Kühne, Angela, additional, Kurnik, Karin, additional, Regensburger, Stephan, additional, Botha, Jaco, additional, Fernandez, Alejandro, additional, Tang, Leilei, additional, and Ozelo, Margareth C., additional

Published
2020
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75. Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B

Author

George, Lindsey A., primary, Ragni, Margaret V., additional, Rasko, John E.J., additional, Raffini, Leslie J., additional, Samelson-Jones, Benjamin J., additional, Ozelo, Margareth, additional, Hazbon, Maria, additional, Runowski, Alexa R., additional, Wellman, Jennifer A., additional, Wachtel, Katie, additional, Chen, Yifeng, additional, Anguela, Xavier M., additional, Kuranda, Klaudia, additional, Mingozzi, Federico, additional, and High, Katherine A., additional

Published
2020
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76. Long‐term safety and sustained efficacy for up to 5 years of treatment with recombinant factor IX Fc fusion protein in subjects with haemophilia B: Results from the B‐YOND extension study

Author

Pasi, K. John, primary, Fischer, Kathelijn, additional, Ragni, Margaret, additional, Kulkarni, Roshni, additional, Ozelo, Margareth C., additional, Mahlangu, Johnny, additional, Shapiro, Amy, additional, P’Ng, Stephanie, additional, Chambost, Hervé, additional, Nolan, Beatrice, additional, Bennett, Carolyn, additional, Matsushita, Tadashi, additional, Winding, Bent, additional, Fruebis, Joachim, additional, Yuan, Huixing, additional, Rudin, Dan, additional, and Oldenburg, Johannes, additional

Published
2020
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78. Angiogenesis‐Related Genes in Endothelial Progenitor Cells May Be Involved in Sickle Cell Stroke

Author

Ito, Mirta T., primary, da Silva Costa, Sueli M., additional, Baptista, Letícia C., additional, Carvalho‐Siqueira, Gabriela Q., additional, Albuquerque, Dulcinéia M., additional, Rios, Vinicius M., additional, Ospina‐Prieto, Stephanie, additional, Saez, Roberta C., additional, Vieira, Karla P., additional, Cendes, Fernando, additional, Ozelo, Margareth C., additional, Saad, Sara Teresinha O., additional, Costa, Fernando F., additional, and Melo, Mônica B., additional

Published
2020
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82. Impact of prophylaxis on health-related quality of life of boys with hemophilia: An analysis of pooled data from 9 countries

Author

Poli Van Creveldkliniek Medisch, Usuba, Koyo, Price, Victoria E, Blanchette, Victor, Abad, Audrey, Altisent, Carmen, Buchner-Daley, Loretta, Carneiro, Jorge D A, Feldman, Brian M, Fischer, Kathelijn, Grainger, John, Holzhauer, Susanne, Luke, Koon-Hung, Meunier, Sandrine, Ozelo, Margareth, Tang, Ling, Antunes, Sandra V, Villaça, Paula, Wakefield, Cindy, Wharfe, Gilian, Wu, Runhui, Young, Nancy L, Poli Van Creveldkliniek Medisch, Usuba, Koyo, Price, Victoria E, Blanchette, Victor, Abad, Audrey, Altisent, Carmen, Buchner-Daley, Loretta, Carneiro, Jorge D A, Feldman, Brian M, Fischer, Kathelijn, Grainger, John, Holzhauer, Susanne, Luke, Koon-Hung, Meunier, Sandrine, Ozelo, Margareth, Tang, Ling, Antunes, Sandra V, Villaça, Paula, Wakefield, Cindy, Wharfe, Gilian, Wu, Runhui, and Young, Nancy L

Published
2019

83. AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B

Author

Manno, Catherine S., Chew, Amy J., Hutchison, Sylvia, Larson, Peter J., Herzog, Roland W., Arruda, Valder R., Tai, Shing Jen, Ragni, Margaret V., Thompson, Arthur, Ozelo, Margareth, Couto, Linda B., Leonard, Debra G.B., Johnson, Frederick A., McClelland, Alan, Scallan, Ciaran, Skarsgard, Erik, Flake, Alan W., Kay, Mark A., High, Katherine A., and Glader, Bertil

Published
2003
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93. Obesity in the global haemophilia population: prevalence, implications and expert opinions for weight management.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service d'hématologie, Wilding, John, Zourikian, Nichan, Di Minno, Matteo, Khair, Kate, Marquardt, Natascha, Benson, Gary, Ozelo, Margareth, Hermans, Cédric, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service d'hématologie, Wilding, John, Zourikian, Nichan, Di Minno, Matteo, Khair, Kate, Marquardt, Natascha, Benson, Gary, Ozelo, Margareth, and Hermans, Cédric

Abstract

Overweight and obesity may carry a significant disease burden for patients with haemophilia (PWH), who experience reduced mobility due to joint inflammation, muscle dysfunction and haemophilic arthropathy. This review aimed to define the prevalence and clinical impact of overweight/obesity in the global population of PWH. A detailed literature search pertaining to overweight/obesity in haemophilia in the last 15 years (2003-2018) was conducted, followed by a meta-analysis of epidemiological data. The estimated pooled prevalence of overweight/obesity in European and North American PWH was 31%. Excess weight in PWH is associated with a decreased range in motion of joints, accelerated loss of joint mobility and increase in chronic pain. Additionally, the cumulative disease burden of obesity and haemophilia may impact the requirement for joint surgery, occurrence of perioperative complications and the prevalence of anxiety and depression that associates with chronic illness. Best practice guidelines for obesity prevention and weight management, based on multidisciplinary expert perspectives, are considered for adult and paediatric PWH. Recommendations in the haemophilia context emphasize the importance of patient education and tailoring engagement in physical activity to avoid the risk of traumatic bleeding.

Published
2018

94. An international survey to inform priorities for new guidelines on von Willebrand disease.

Author

Kalot, Mohamad A., Al‐Khatib, Mohammed, Connell, Nathan T., Flood, Veronica, Brignardello‐Petersen, Romina, James, Paula, Mustafa, Reem A., Abdul‐Kadir, Rezan, Ameer, Barbara, Arapshian, Alice, Ozelo, Margareth C., Couper, Susie, Grow, Jean, Eikenboom, Jeroen, Giraud, Nicolas, Haberichter, Sandra, Jacobs‐Pratt, Vicki, Di Paola, Jorge, Konkle, Barbara A., and Kouides, Peter

Subjects
VON Willebrand disease, MEDICAL personnel, VON Willebrand factor, DIAGNOSIS, WOMEN patients, GUIDELINES
Abstract

Introduction: von Willebrand disease (VWD) is an inherited bleeding disorder caused by a quantitative or qualitative dysfunction of von Willebrand factor. Clinicians, patients and other stakeholders have many questions about the diagnosis and management of the disease. Aim: To identify topics of highest importance to stakeholders that could be addressed by guidelines to be developed by the American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation (NHF) and the World Federation of Hemophilia (WFH). Methods: A survey to determine and prioritize topics to be addressed in the collaborative development of guidelines for VWD was distributed to international stakeholders including patients, caregivers and healthcare providers (HCPs). Representatives of the four organizations coordinated the distribution strategy. The survey focused on both diagnosis and management of VWD, soliciting 7‐point Likert‐scale responses and open‐ended comments, in English, French and Spanish. We conducted descriptive analysis with comparison of results by stakeholder type, gender and countries' income classification for the rating questions and qualitative conventional content data analysis for the open‐ended responses. Results: A total of 601 participants responded to the survey (49% patients/caregivers and 51% healthcare providers). The highest priority topics identified were diagnostic criteria/classification, bleeding assessment tools and treatment options for women and surgical patients. In contrast, screening for anaemia and differentiating plasma‐derived therapy versus recombinant therapies received lower ratings. Conclusion: This survey highlighted areas of importance to a diverse representation of stakeholders in the diagnosis and management of VWD, providing a framework for future guideline development and implementation. [ABSTRACT FROM AUTHOR]

Published
2020
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95. Creating a Population Model for PK-Tailored Dosing Using Real-World Data from the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) Platform

Author

Chelle, Pierre, primary, Yeung, Cindy, additional, Bonanad Boix, Santiago, additional, Morales, Juan Cristobal, additional, Ozelo, Margareth C, additional, Megias Vericat, Juan E., additional, Iorio, Alfonso, additional, Spears, Jeffrey, additional, Mir, Roser, additional, and Edginton, Andrea N, additional

Published
2018
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96. Incidence of Inhibitors in a Previously Untreated Patients with Severe Hemophilia Α Cohort Treated with a Single Third-Generation Recombinant Factor VIII Concentrate

Author

Prezotti, Alessandra N L, primary, Cerqueira, Monica H, additional, Renni, Marilia, additional, Ferreira, Clarissa, additional, Pinto, Ieda S., additional, Roberti, Maria do Rosário, additional, Ribeiro, Rosangela, additional, Villaça, Paula Ribeiro, additional, Orletti, Maria P S V, additional, Costa-Lima, Carolina, additional, Yamaguti-Hayakawa, Gabriela G, additional, Medina, Samuel S, additional, and Ozelo, Margareth C, additional

Published
2018
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99. Proliferative Sickle Cell Retinopathy in SS and SC Hemoglobinopathies: Identification of New Candidate Genes

Author

da Silva Costa, Sueli Matilde, primary, Ito, Mirta Tomie, additional, Souza, Bruno Batista, additional, Cruz, Pedro Rodrigues Souza, additional, Bapista, Letícia de Carvalho, additional, Rios, Vinicius Mandolesi, additional, Viturino, Marina Gonçalves Monteiro, additional, Pietro, Stephanie Ospina, additional, Ozelo, Margareth C, additional, Costa, Fernando F., additional, and Melo, Monica Barbosa, additional

Published
2018
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100. Long-term safety and efficacy of turoctocog alfa in prophylaxis and treatment of bleeding episodes in severe haemophilia A: Final results from the guardian 2 extension trial

Author

Lentz, Steven R., primary, Janic, Dragana, additional, Kavakli, Kaan, additional, Miljic, Predrag, additional, Oldenburg, Johannes, additional, C. Ozelo, Margareth, additional, Santagostino, Elena, additional, Suzuki, Takashi, additional, Zupancic Šalek, Silva, additional, Korsholm, Lars, additional, Matytsina, Irina, additional, and Tiede, Andreas, additional

Published
2018
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