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Materials and methods A retrospective cohort study of cases with tissue diagnosis of epibulbar choristoma in 2 centers presenting during the period: 2000–2016 with focus on cases of complex and osseous choristoma. Demographic and clinical data were collected by the resident from medical records. The histopathological slides were reviewed by 2 pathologists and cases of complex and osseous choristoma were analyzed by biostatical staff. Results 120 epibulbar choristomas were identified. 13/120 patients (10.8%) with complex choristoma and 2/120 patients (1.7%) with osseous choristoma. 15 cases were further analyzed: 7 were males and 8 were females. Mean age at presentation was 7.6 year. Commonest location was temporal in 66.6%. The presence of smooth muscle component was associated with a larger size choristoma (p = 0.042). 73.3% had other ophthalmic manifestations (mostly eyelid anomalies) while 9 systemic associations (mostly Goldenhar's syndrome) were found in 8/13 cases of complex choristoma. Conclusion Epibulbar complex and osseous choristomas are rare. Histopathologically, the presence of smooth muscle significantly correlates with the lesion size. Complex choristoma is more likely to be associated with systemic manifestations. Further genetic studies for this condition are recommended., Highlights • Choristomas are congenital tumors that may affect the epibulbar area. • They arise from ectopic pluripotent cells differentiating into simple or complex choristoma. • We present our cases to highlight interesting ophthalmic and/or systemic associations. • This might open the door for future molecular genetic testing. • Significant association is found between smooth muscle component and larger size choristoma.

An osseous choristoma is a rare benign lesion consisting of normal bone tissue; it is seen in abnormal locations. It is most often seen in the posterior 1/3 of the tongue in the head. Its etiopatogenesis is controversial, and till date, less than 100 cases have been reported in the literature. Although a lingual osseous choristoma is asymptomatic, in some patients, symptoms such as swelling sensation in the throat, globus pharyngeus, dysphagia, retching, nausea, and sore throat have been reported. In this article, a 41-year-old female patient admitted to our clinic with throat pain and globus pharyngeus who underwent an excision from the region of radix lingua and the result of histopathological examination was reported as “osseous choristoma” was presented and related literature is reviewed.

Osseous choristoma of soft tissue in the oral cavity is rare. The choristoma is a tumor-like mass of normal cells in an abnormal location. In this report, a case of osseous choristoma of the palate in a 37-year-old male patient was reported. Approximately 6 × 5 mm pedunculated healthy colored and hard mass was observed in the median palate. The mass was surgically removed. Microscopic examination of the hematoxylin and eosin-stained sections of the mass revealed that a dense lamellar bone nodule was surrounded by fibrous connective tissue under the squamous epithelium. Immunohistochemical analysis revealed that the mass was negative for S-100 protein, cytokeratin, and epithelial membrane antigens. According to these findings, the final pathologic diagnosis confirmed that the mass was an osseous choristoma.

Osseous lesions of the tongue, also referred to as osseous choristomas, are benign growths of bony tissue. These lesions are not true neoplasms but rather represent growth of normal tissue at an abnormal location. Clinically, they appear as exophytic masses of the tongue, and they are treated by surgical excision. Lingual osseous choristomas are rare entities, with only 71 reported cases in the literature. We present the case of a lingual osseous choristoma of the tongue base in a 21-year-old female. Of the cases of lingual osseous choristoma reported in the literature, ours is only the fifth case to involve this location.

Purpose To describe the clinical features and histopathology of epibulbar osseous choristoma in a series of patients. Methods Noncomparative case series with chart review of 8 patients. Results At presentation, the mean age of the patients was 19 years (median, 19 years; range, 0.8-38 years), with 6 women and 2 men (6 Caucasian, 1 Hispanic, and 1 African American). There were no related systemic syndromes, and visual acuity was unaffected in all cases. The choristoma was superotemporal (n = 8, 100%), with epicenter located in the fornix (n = 8, 100%), deep to Tenon fascia (n = 8, 100%), and of yellow (n = 2, 25%), white (n = 2, 25%), or pink (n = 4, 50%) color. The mean basal dimension was 9 mm (median, 10 mm; range, 3.5-14 mm), and mean thickness was 4 mm (median, 4 mm; range, 2-5 mm). Four cases were managed with observation and 4 with surgical excision, revealing tumor base adherent to the episclera (n = 2, 50%) or loose within Tenon fascia (n = 2, 50%). There were no cases to demonstrate intrascleral involvement, growth, or recurrence. Conclusions Epibulbar osseous choristoma is a congenital lesion of mature bone located superotemporally in the fornix at the level of Tenon fascia or episclera in young patients.

Osseous choristoma is a rare, benign lesion that presents at an abnormal location as a tumor-like mass comprising mature bone tissue. We report the case of a 50-year-old man who developed osseous choristoma in the submandibular legion. The patient was referred to our clinic in May 2011 with a 4-year history of a progressively growing tumor-like swelling in the submandibular region. The lesion was a hard, mobile, well-circumscribed, globular mass. Computed tomography revealed a heterogeneous high-density mass on the left side of the submandibular region. There was no bony connection to the mandible. Bone scanning revealed an increased uptake of 99mTc labeled hydroxymethylene diphosphonate by the lesion. The tumor was resected via an extraoral approach under general anesthesia. During surgery, it was observed that the tumor was not closely adherent to adjacent structures such as muscles or the submandibular salivary gland. Histopathological examination of the resected specimen revealed features indicative of osseous choristoma. The postoperative course was uneventful and there has been no evidence of recurrence till date.

A choristoma is a benign tumour-like growth consisting of normal tissue in an abnormal site. Seven cases of mixed osseous and cartilaginous choristoma of the tongue have been reported in the literature, only one on the anterior tongue. Here we review the literature regarding osseous and cartilaginous choristomas and report only the second case of mixed osseous choristoma to occur on the anterior dorsal tongue.

Osseous choristoma is a rare, benign lesion which usually develops in the tongue adjacent to the foramen caecum. This report presents a case occurring in the palatal region, as well as a review of the literature. A differential diagnosis of this condition from other bone-forming lesions of the soft tissue is also discussed.

We report a case of osseous choristoma on the tongue radix. A 25-year-old woman with Turner syndrome was seen for a 10-year-old asymptomatic tongue tumor. Assuming it to be benign, we totally resected the tumor through an oral approach under general anesthesia. The pathological diagnosis was osteoma of the tongue, called osseous choristoma. She had undergone estrogen and progestogen treatment for Turner syndrome. We concluded that estrogen treatmenat triggered osseous choristoma due to accelerated new bone formation.

This report presents a case of osseous choristoma in the submandibular region of a 33-year-old female. Her chief complaint was painless swelling in the submandibular region. Panoramic radiography showed a well-defined, round, radiopaque lesion near the inferior border of the right mandibular angle. Coronal and sagittal tomographic images indicated a high-density area in the right submandibular region with no bony connection. The lesion was diagnosed as an osseous choristoma based on histopathological examination of the surgical specimen. A 1-year follow-up period was uneventful.

Epibulbar osseous choristomas typically present, in the young, as a supero-temporal subconjunctival nodule and radiographic imaging often shows a densely radio-opaque fleck on the sclera--this often being misinterpreted as a parabulbar foreign body. Four illustrative cases are presented.

This case report is the third ever reported of a recurrent intraoral osseous choristoma. The lesion had manifested twice in the left mandibular buccal vestibule of a 63-year-old Caucasian female. The patient was treated with wide local excision on both occasions. We believe that the lesions may have arisen as a result of previous trauma, although the exact etiology of the lesions is unknown. Interestingly, the recurrent lesion contained satellite nodules of bone, which suggests that the osseous choristoma may recur yet again.

Summary Choristomas are defined as proliferations of histologically normal tissue located in an abnormal position. Osseous choristomas of oral soft tissue are rare lesions, especially in children, occurring most frequently in the tongue, and less commonly in other sites such as buccal mucosa, palate and alveolar mucosa. It has been suggested that osseous choristomas have developmental or traumatic origins. Definite diagnosis can only be determined after histologic examination, whereupon the treatment of choice is surgical excision. Here we present, what is to our knowledge, a second case of buccal osseous choristoma in a pediatric patient, along with a brief review of the current, pertinent literature.

Choristoma of the eye are common epibulbar and ocular tumours in children, but osseous choristoma of the eye are very rare with few case reports being published in literature. We report one such case which presented in a 14 year female child who had small tiny nodule in the left eye present since birth with gradual increase in size. Excision biopsy was done. Histologically, nodule was composed of mature lamellated bone with a surrounding connective tissue.

El osteoma lingual (coristoma oseo lingual) es una alteracion del desarrollo poco comun, con menos de 100 casos reportados mundialmente. La localizacion mas frecuente de esta lesion es la cara dorsal de la lengua. Su etiologia no es completamente clara. Debido a su escasa incidencia, reportamos un nuevo caso, en una paciente de sexo femenino de 12 anos de edad. En este articulo tambien se revisara la epidemiologia, histologia y patogenesis de esta condicion. Palabras clave: Osteoma lingua, Coristoma, Histologia. Lingual osteoma (lingual osseous choristoma) is a rare condition, with fewer than 100 cases reported. The most common location of this lesion is the dorsal surface of the tongue. Because of its low incidence, we present a new case that ocurred in a 12 years old woman. This article also review the epidemiology, histology and pathogenesis of this condition. Keywords: Lingual Osteoma, Choristoma, Histology.

Osseous choristoma is a normal bone tissue in an ectopic position. In the oral region lingual localization occurs more frequently and the mass is generally localized on the dorsum of the tongue. Definitive diagnosis is obtained only after histopathologic examination. The etiology remains already debatable. The treatment of choice is surgical excision. In this paper we present a case of tongue osseous choristoma and a review of the literature.

The topic of this case report is a rare subconjuctival osseous choristoma that corresponded to the left lateral sunconjunctiva and canthus. A 20-year-old man was asymptomatic when he arrived for the examination. His full ophthalmic examination was normal. Orbital computerized tomography was concordant with osseous lesion. Osseous choristomas are the rarest forms of ocular choristomas, they are usually being defined as sporadic, and they are found at the superior temporal region of the episclera. In our case, choristoma was in the lateral canthus of the left eye. We had administered surgical excision by reason of the patient’s cosmetic requirement. We had noted that the lesion was adherent to conjunctiva but not to the sclera and the muscles. After surgical treatment, we saw mature heterotrophic osseous tissue in subconjunctival area and Haversian canals in compact bone tissue.

Epibulbar osseous choristomas are rare congenital simple choristomas consisting of pure bone on the sclera. It is usually recognized in childhood and most often located in the superotemporal quadrant. A case of 7-year-old male who presented with a history of mass in the left eye was reported in this paper. The mass had been present since birth but had showed slight enlargement during the last 6 months. Examination revealed a 7 × 5 mm reddish, hard, and mobile mass located in the superotemporal quadrant. Excisional biopsy was done. On histopathological examination, excised mass was found to be composed of mature bony trabeculae enclosing osteocytes, and diagnosis of epibulbar osseous choristoma was made.

Lingual osseous choristoma is an extremely rare condition, of which only 61 cases have been reported. Monserrat in 1913 was the first to report this bony lesion on the dorsum of the tongue and it was labelled as lingual osteoma, the term that normally describes neoplastic pathology. Krolls et al changed this term later to osseous choristoma, which means normal tissue in an abnormal location. The aetiology and pathogenesis of lingual osseous choristoma remain debatable. We report a case of lingual osseous choristoma and review the literature. Keywords : Lingual osteoma; Osseous choristoma; Torus. Libyan Journal of Medicine Vol. 2 (1) 2007

We report a case of binary occurrence of osseous choristoma of the tongue in a 25-year-old woman. To date, 82 cases of osseous choristoma of the oral region have been reported. However, the binary occurrence of tumors has not been described previously.

This report details the gross and histopathologic findings of an unusual complex choristoma at the lateral canthus. Although this lesion displays elements of hair follicle nevus, bulbar dermoid, epibulbar osseous choristoma, and accessory tragus, it does not fit neatly in any of these categories. We propose that this lesion is the result of faulty migration of pluripotential cells during embryogenesis.

Journal of Pediatrics, The - In Press.Proof corrected by the author Available online since lundi 6 juin 2016

Background: Choristomas are benign, congenital tumours composed of normal tissue in an abnormal location. Osseous choristomas represent the rarest form of epibulbar choristomas, with now 65 cases reported in the literature. We did a retrospective clinicopathological study of all patients with epibulbar osseous choristoma observed at our institution since 1982 and updated the last review of the literature. History and Signs: Three Caucasian male patients, aged between 3 months and 11 years, were identified. All osseous choristomas were located under the superotemporal bulbar conjunctiva of the right eye. Therapy and Outcome: All lesions were managed with surgical excision. Histopathology revealed the presence of lamellar bone in all cases, one of which was associated with a dermolipoma. Conclusions: We report a small rare case series of 3 epibulbar osseous choristomas and did a review of the literature. In one patient, the osteoma was associated with a dermolipoma, corresponding to the fourth reported complex choristoma of this type, in an otherwise normal eye, in the literature.

Lingual osseous choristoma is an extremely rare condition, of which only 61 cases have been reported. Monserrat in 1913 was the first to report this bony lesion on the dorsum of the tongue and it was labelled as lingual osteoma, the term that normally describes neoplastic pathology. Krolls et al changed this term later to osseous choristoma, which means normal tissue in an abnormal location. The aetiology and pathogenesis of lingual osseous choristoma remain debatable. We report a case of lingual osseous choristoma and review the literature. Keywords: Lingual osteoma; Osseous choristoma; Torus Libyan Journal of Medicine Vol. 2 (1) 2007

Lingual osseous choristoma is a rare lesion. We describe a case of lingual osseous choristoma in a 23 year old female. The lesion appeared as a pedunculated mass measuring about 4×4×8 mm, near the foramen caecum of the tongue. The mass was excised under general anesthesia. Histologically this lesion consisted of a well circumscribed mass of dense lamellar bone with Haversian canals. The bony nodule was bordered by a narrow band of dense fibrous tissue, and covered with squarnous mucosa. The excised area of the tongue was healed and free of recurrence one year later.

Ocular osseous choristoma, a rare idiopathic benign deposit of bone, is typically a static epibulbar lesion that occurs sporadically in the supertemporal quadrant of an otherwise normal eye. The subject of this report is a unique U-shaped subcutaneous osseous choristoma that did not involve the eye itself but rather conformed to the right lateral canthus in an otherwise normal 2-year-old boy.

Lingual osseous choristoma is an extremely rare condition, of which only 61 cases have been reported. Monserrat in 1913 was the first to report this bony lesion on the dorsum of the tongue and it was labelled as lingual osteoma, the term that normally describes neoplastic pathology. Krolls et al changed this term later to osseous choristoma, which means normal tissue in an abnormal location. The aetiology and pathogenesis of lingual osseous choristoma remain debatable. We report a case of lingual osseous choristoma and review the literature.

Choristoma is a benign tumour defined as normal tissue in an ectopic location. Osseous choristoma, one subtype of this entity, occurring within the orbit has rarely been reported in the world literature. We report a 6-year-old girl with bilateral ocular osseous choristomas who presented with palpable nodules protruding from both upper lids. The radiological and clinical findings are described and previous reports are reviewed.

A case of osseous choristoma in the buccal mucosa of a 9 -year-old girl is described. In the literature only 11 cases have been reported previously. The lesion measured 8.5×8.5mm and was removed under local anesthesia.Histologically, the lesion consisted of a well circumscribed mass of dense lamellar bone, surrouded by a thin layer of fibrous connective tissue. The excised area of bum' mucosa healed and was free of recurrence after 5 months.