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51. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

Author

Holman, Rr, Bethel, Ma, Mentz, Rj, Thompson, Vp, Lokhnygina, Y, Buse, Jb, Chan, Jc, Choi, J, Gustavson, Sm, Iqbal, N, Maggioni, Ap, Marso, Sp, Öhman, P, Pagidipati, Nj, Poulter, N, Ramachandran, A, Zinman, B, Hernandez, Af, EXSCEL Study Group, : Califf RM, Patel, R, George, J, Sourij, H, Wong, Yw, Hannan, K, Sellers, Ma, Gottlieb, P, Lavender, P, Leloudis, D, Meadows, Y, Larson, D, Anderson, H, Elkins, M, Stone, A, Tisch, A, Perkins, L, Sanders, K, Campbell, C, Kennedy, I, Heal, P, Masterson, M, Darbyshire, J, Mumtaz, L, Athwal, R, Ferch, A, Batra, P, Durborow, L, Vincent, J, Woodall, A, Flanagan, T, Katona, B, Reicher, B, Pozzi, E, Oulhaj, A, Coleman, R, Rouleau, Jl, Pocock, Sj, Gorelick, F, Mcmurray, J, Riddle, M, Gagel, R, Collier, T, Markovic, T, Kong, Aps, Hian, Sk, Scott, R, Panelo, A, Yoon, Kh, Sheu, W, Sritara, P, Linong, J, Pan, C, Yong, H, Schernthaner, G, Mathieu, C, Tankova, T, Widimsky, P, Hanefeld, M, Keltai, M, Wainstein, J, del Prato, S, Pirags, V, Jakuboniene, N, Kooy, A, Dziemidok, P, Veresiu, Ia, Dreval, Av, Murin, J, Torello, Al, Sattar, N, Parkhomenko, O, Omar, M, Diaz, R, Lopes, R, Lanas, F, Urina Triana, M, Leiva-Pons, Jl, Aguliera, D, Bergenstal, R, Goodman, S, Yale, Jf, Caterson, I, Weng, J, Hu, D, Junbo, G, Zannad, F, Anoop, M, Ambrish, M, Gallegos, Ja, Green, Jb, Akerblom, A, Alexander, K, Al-Khatib, S, Armaganijan, L, Barros, P, Batit, M, Bernacki, G, Bernandez, S, Bloomfield, G, Clausen, E, De Souza Brito, F, Devore, A, Dombrowski, K, Eapen, Z, Gellad, Z, George, D, Guimaraes, P, Halim, S, Harrison, R, Hawes, J, Hess, C, Hyland, K, Jackson, L, Jones, S, Jordan, D, Katz, M, Kong, D, Koshizaka, M, Lakey, W, Leblanc, T, Leonardi, S, Luo, N, Mahaffey, K, Mandawat, A, Mehta, R, Melloni, C, Morse, M, Pagidpati, N, Patel, C, Patel, K, Pokorney, S, Posvic, T, Rao, M, Roe, M, Shah, B, Tillmann, H, Truffa, A, Zazula, A, Zeitler, E, Sicer, M, Ulla, Mr, Maffei, L, Klyver, Mi, Calella, P, Alvarisqueta, A, De La Fuente RL, Aizenberg, D, Roque, F, Cruciani, A, Frechtel, G, Gelersztein, E, Villarino, A, Mallagray, M, Nardone, L, Zaidman, C, Novaretto, L, Bartolacci, I, de Salvo, M, Delcourt, C, Crimmins, D, Jackson, R, O’Neal, D, Colman, P, Jeffries, W, Mah, Pm, Wittert, G, Proietto, J, Amerena, J, Marks, S, Tan, R, Colquhoun, D, Pieber, T, Drexel, H, Prager, R, Schnack, C, Hoppichler, F, Fasching, P, Francesconi, C, Luger, A, Schoenherr, Hr, Ebenbichler, C, Paulweber, B, Shernthaner, G, Verhaegen, A, Vanuytsel, J, Thissen, Jp, e Silva P, Barros, Gonzaga, C, Borges, J, Hissa, M, Rea, R, Rossi, P, Chacra, A, Eliaschewitz, F, Garbelini, B, Felicio, J, Rassi, N, Rossi, F, Nunes dos Santos, M, e Farias F, Bandeira, Lisboa, H, e Forti A, Costa, Saraiva, Jk, Kovacheva, S, Levterov, G, Sheinkova, G, Ilieva, E, Lyubenova, L, Damyanova, V, Gushterova, V, Mincheva, L, Illiev, D, Ivanov, V, Bobeva, R, Nikitov, Z, Shumkova, R, Lefterov, In, Zaharieva, S, Videva, V, Yakov, A, Cheung, S, Elliott, T, Mehta, P, Ross, S, Sigal, R, Woo, V, Jaffer, S, Kuritsky, R, Bell, A, Dumas, R, Gosselin, G, Robitaille, Y, Greenspoon, A, Lochnan, H, Tytus, R, Leiter, L, Pandey, A, Punthakee, Z, Dube, F, Sigalas, J, Pearce, M, Woodford, T, Paul, P, Bourgeois, R, Conway, R, Mazza, G, Hatheway, R, Misterski, J, Raffo, C, Olivares, C, Godoy, J, Potthoff, S, Santibañez, C, Larenas Yanez GJ, Gu, W, Shen, F, Ma, J, Guo, X, Li, Q, Du, Y, Hu, J, Ji, L, Li, Y, Deng, H, Feng, Y, Liu, L, Mu, Y, Ma, C, Qu, S, Wang, J, Wang, Y, Yuan, Z, Zhang, L, Zhou, S, Yang, T, Dong, Y, Liu, D, Coronel Arroyo, J, Perez Amador, G, Botero Lopes, R, Jaramilo, C, Orozco Linares, A, Cure Cure CA, Hernandez Triana, E, Molina de Salazar DI, Marin, Cr, Jaramilo Gomez CJ, Kellinerova, I, Adamkova, V, Krami, P, Brychta, T, Havelkova, J, Pantikova, K, Schoper, F, Pohl, W, Schumm-Draeger, Pm, Julius, U, Tschöpe, D, Hamann, A, Seissler, J, Schellong, S, Rose, L, Becker, B, Linn, T, Oerter, Em, Strotmann, Hj, Mölle, A, Pfutzner, A, Forst, T, Schäufele, T, Mugge, A, Lehrke, M, Meyer-Pannwitt, U, Mehling, H, Simon-Wagner, I, Schenkenberger, I, Busch, K, Hermes, S, Milek, K, Landers, B, Grueneberg, M, Braun, M, Nothroff, J, Kamke, W, Hergdt, G, Duengen, Hd, Kleinertz, K, Kuesters, D, Boenninghoff, Ah, Appel, Kf, Schaefer, A, Bieler, T, Ozaki, R, Luk, Aoy, Chu, Dw, Cheung-Wong, Mm, Siu, Dc, Yan, Bpy, Kung, K, Wong, Sys, Tsang, Cc, Yeung, Vt, Cheung, Bm, Tse, Hf, Hodi, G, Nagy, K, Lippai, J, Takacs, J, Fulop, T, Gaal, Z, Pauker, Z, Foldesi, I, Simon, J, Oroszan, T, Futo, L, Bezzegh, K, Nagy, A, Vandorfi, G, Kiss, J, Kesmarki, N, Kis, E, Papp, A, Kovacs, A, Szakal, I, Palinkas, A, Czegany, Z, Voros, P, Reiber, I, Kerenyi, Z, Dezso, E, Wittman, I, Penzes, J, Ples, Z, Taller, A, Farago, K, Kis, Jt, Zilahi, Z, Molnar, M, Barkai, L, Mileder, M, Szentpeteri, I, Peterfai, E, Lovasz, O, Mosenzon, O, Minuchin, O, Jaffe, A, Vishlitsky, V, Shimon, I, Bashkin, A, Stern, N, Elias, N, Bental, T, Butnaru, A, Lewis, B, Adawi, F, Nseir, W, Klainman, E, Herskovits, T, Cignarelli, M, Rotella, Cm, Ambrosio, G, Pozzilli, P, Genovese, S, Cavarape, A, Salvioni, A, Sokolova, J, Strautina, I, Teterovska, D, Stalte, V, Pastare, S, Leitane, I, Lagzdina, L, Andersone, I, Eglite, R, Stelmane, I, Levinger, A, Barsiene, L, Sulskiene, M, Varanauskiene, E, Danyte, E, Urbanaviciene, E, Urbanavicius, V, Zabuliene, L, Juskiene, R, Velaviciene, A, Kakariekiene, V, Augusteniene, A, Velickiene, D, Lasiene, J, Dauksiene, D, Caponis, J, Tan, At, Ramanathan, L, Hassan, Mra, Tan, F, Ong, Tk, Foo, Sh, Ghani, Ra, Cheah, Wk, Sanchez Mijangos JH, Cabrera Jardines, R, Barrientos Perez, M, Sauque Reyna, L, Alcocer Gamba MA, Villeda Espinosa, E, Tamez Perez HE, De La Garza Hernandez NE, Lopes, Sm, Ramirez Diaz SP, Reyes Sanchez, R, Márquez-Rodriguez, E, Köse, V, Voors-Pette, C, Oldenburg-Ligtenberg, Pc, van Kempen WW, Cox, K, Hoogendyk, J, Swinkels-Diepenmaat, L, Rojas-Lingan, G, Kentgens, S, Schipperen, S, de Valk HW, Swart, H, van Bemmel, B, Hoogslag, Pam, Diamant, M, Serné, Eh, Hamer, A, Wilson, S, Fisher, N, Dixon, P, Chaudhri, O, Crawford, V, Quinn, D, Nirmalaraj, K, Dunn, P, Gillies, J, Cutfield, R, Krebs, J, Helm, C, Kerr, J, Pryke, J, Ebo, G, Denopol, M, Ang, E, Uy, N, Jimeno, C, Mirasoi, R, Paz Pacheco, E, Custodio, M, Nicodemus, N Jr, Catindig, Ea, Magno, M, Tirador, L, Cylkowska, B, Stasinksa, T, Silwinska, T, Sroka, M, Piepiorka, M, Korzeniak, R, Mirecka, H, Zaluska, R, Pupek-Musialik, D, Homenda, W, Grabowska, A, Okopien, B, Niegowska, J, Pogorzelska, H, Mikolajczyk-Swatko, A, Sikorski, M, Sowinski, D, Tahk, Sj, Kim, Yn, Nam, Cw, Rim, Sj, Kim, Cj, Choi, Km, Lee, Ik, Kim, Ij, Namgung, J, Moon, Kw, Kim, Ks, Oh, Bh, Lee, Wy, Choi, Sh, Kim, Es, Moon, S, Mindrescu, Nm, Aron, G, Graur, M, Hancu, N, Mlitaru, C, Nafornita, V, Szilagyi, I, Popa, Ar, Angelescu, Lm, Negrisanu, Gd, Zaharie, Dg, Culman, Mi, Vacaru, G, Munteanu, M, Constantinescu, S, Tivadar, S, Dreval, A, Barbarash, O, Strongin, L, Dogadin, S, Suplotova, L, Izmozherova, N, Marasaev, V, Khokhlov, A, Repin, A, Turova, E, Bondar, I, Samoylova, Y, Sherenkov, A, Smolenskaya, O, Zrahevskiy, K, Koshelskaya, O, Obrezan, A, Dzupina, A, Stevlik, J, Buganova, I, Pella, D, Vinanska, D, Jascur, J, Micko, K, Sosovec, D, Philippiova, A, Olexa, P, Fedacko, J, Selecky, J, Nicolau, J, Mediavilla Garcia, J, Botella Serrano, M, Lecube, A, Arguelles, I, Sabán, J, Gómez Cerezo, F, Soto, A, Bellido, D, Sucunza Alfonso, N, Vendrell Ortega, J, Alvarez, L, Garcia Puig, J, Angustias Quesada, M, Contreras Gilbert, J, Almeida, Ca, Tinahones, Fj, Garcia Ortiz, L, Gómez Marcos MA, Aomar, I, Fernández Balsells, M, Distiller, L, Padayachee, T, Badat, A, Ebrahim, I, Naiker, P, Ranjith, N, Kelfkens, Y, Makan, H, Mogashoa, S, Fulat, M, Carim-Ganey, N, Coetzee, K, Govender, T, Nortje, H, Wilhase, A, Seedat, S, Gani, M, Ellis, G, Rheeder, P, Wing, J, Blignaut, S, Kaplan, H, Lottering, H, Pillai, P, Louw, C, Coetzer, T, Sheu, Whh, Chen, Jf, Yang, Cy, Tseng, St, Wang, Cy, Lai, Wt, Hung, Yj, Hsieh, Ic, Su, Sl, Pei, D, Benjasuratwong, Y, Purewal, T, Milward, A, Dimitropoulos, I, Kumar, S, Barber, T, Wiles, P, Dang, C, Adler, A, Philip, S, Bellary, S, Price, D, Oelbaum, R, Heller, S, Sathayapalan, T, Clark, J, Leese, G, Simpson, H, Kilvert, A, Dawson, A, Hall, T, Takhar, A, Bundy, C, Harvey, P, Maxwell, S, Asamoah-Owusu, Nj, Mcknight, J, Chatterjee, S, Calvert, J, Wright, A, Macrury, S, Macfarlane, D, Johnson, A, Litchfield, J, Field, B, Koval, O, Larin, O, Levchenko, O, Martynyuk, L, Maslyanko, V, Rudyk, I, Suprun, Y, Tseluyko, V, Botsyurko, V, Vatutin, M, Fushtey, I, Grishyna, O, Kuskalo, P, Panina, S, Pererva, L, Prysupa, L, Teliatnikova, Z, Sokolova, L, Vlasenko, M, Berenfus, V, Gyrina, O, Kopytsya, M, Vizir, V, Vayda, M, Shanik, M, Headapohl, D, Pahl, J, Aronoff, S, Bartkowiak, A Jr, Chang, A, Gaudiani, L, Kayne, D, Look, M, Patel, N, Moran, J, Stout, E, Tsao, J, Struble, R, Fishman, N, Rodbard, H, Lucas, K, Dugano-Daphnis, P, Merrick, B, Nadar, V, Severa, L, Sorli, C, Chang, M, Reed, J III, Grunberger, G, Bain, C, Bestermann, W Jr, Morawski, E, White, J, Azizad, M, Ukwade, P, Anekwe, A, Jimenez, A, Weiss, D, Green, S, Overcash, J, Eaton, C, Roseman, H, Soler, N, Mikell, F, Manos, P, Levinson, L, Claxton, E Jr, Weiss, R, Argoud, G, Bickel, L, Wilson, J, Short, B, Webster, B, Mcneill, R, Schnall, A, Force, R, Phillips, L, Bybee, K, Forker, A, Denham, D, Vonderhaar, T, Pullman, J, Kruger, D, Whitehouse, F, Wysham, C, Baron, M, Kravitz, A, Dushkin, H, Manning, Mb, Wine, A, Jaffrani, N, Chadha, C, Sperl-Hillen, J, Busch, R, Estevez, R, Robbins, D, Rassouli, N, Garvey, T, Oparil, S, Eckel, R, Mcdermott, M, Rasouli, N, Mcgill, J, Corder, C, Klonoff, D, Mills, R, Earl, J, Kessel, J, Cuddihy, R, Zimmerman, R, Dayamani, P, Oral, E, Zimering, M, Marks, J, Farnsworth, K, Sugimoto, D, Toth, P, Bhargava, A, Mcguire, D, Rohatgi, A, Davies, M, Peden, E, Wyne, K, Alfonso, L, Seyoum, B, Akpunonu, B, Feinglos, M, Reaven, P, Soule, J, Luttrell, L, Schactman, B, Canadas, R, Boggs, B, Abbott, L, Herring, C, Roberts, L, Hage-Korban, E, Schubart, U, Taylon, A, Tannenbaum, A, Kingsley, J, Lenhard, J, Biscoveanu, M, Cohen, J, Donovan, D, Laferrere, B, Thompson, N, Wade, T, Detweiler, R, Henson, B, White, A, Cavale, A, Ravi, C, Thomas, A, Goodman, H, Kalen, V, Fox, D, Dauber, I, Rizvi, S, Marcus, A, Mulford, M, Higgins, A, Chane, M, Bland, V, Osunkoya, A, Suresh, D, Khan, S, Anastasi, L, Bajaj, M, Eisen, H, Mudaliar, Sr, Powell, S, Carr, K, Tripathy, D, Azad, N, Wakefield, P, Acheatel, R, Bressler, P, Dean, J, El Shahawy, M, Gilbert, J, Haque, I, Humiston, D, Ison, R, Karounos, D, Lillestol, M, Ferrier, N, Labroo, A, Vo, A, D’Agostino, R, Dulin, M, Mcwilliams, A, Hargrove, J, Blumberg, E, Jackson, B, Staniloae, C, Salacata, A, Hidalgo, H Jr, Nicol, P, Digiovanna, M, Soufer, J, Mahabadi, V, Akinboboye, O, Arauz-Pacheco, C, Neutel, J, Dungan, K, Benson, M, Powell, T, Gandy, W, Rovner, S, Berk, M, Khan, A, Ledesma, G, Madu, I, Erickson, B, Radbill, M, Graves, M, Kaczmarek, G, Giep, S, Baldauf, C, Golden, G, Lesh, K, Davis, C, Godbole, N, Kirby, W, Razzaque, N, Bhatt, B, Wilson, M., Internal medicine, ACS - Diabetes & metabolism, and ACS - Microcirculation

Subjects
Male, medicine.medical_specialty, EXSCEL Study Group, Injections, Subcutaneous, 030209 endocrinology & metabolism, Type 2 diabetes, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Placebo, Article, Drug Administration Schedule, GLP1-agonists, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Interquartile range, Internal medicine, Diabetes mellitus, General & Internal Medicine, medicine, Humans, Hypoglycemic Agents, Least-Squares Analysis, Aged, Glycated Hemoglobin, business.industry, Venoms, Semaglutide, Incidence, Type 2 diabetes, GLP1-agonists, exenatide, cardiovascular effects, General Medicine, 11 Medical And Health Sciences, Middle Aged, medicine.disease, Surgery, Albiglutide, Editorial, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Exenatide, Dulaglutide, Female, business, Peptides, cardiovascular effects, medicine.drug
Abstract

BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy. RESULTS: In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P

Published
2017
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58. State of the art psychopharmacological treatment options in seasonal affective disorder

Author

Yıldız, Mesut, Batmaz, Sedat, Songur, Emrah, Oral, E. Timuçin, and Bölüm Yok

Subjects
mental disorders, Psychopharmacological treatment, Seasonal affective disorder, SAD, Antidepressants, behavioral disciplines and activities
Abstract

PubMed ID: 26938817 Seasonal affective disorder (SAD) is defined as a subtype of mood disorders in DSM 5, and it is characterized by a seasonal onset. SAD is proposed to be related to the seasonal changes in naturally occurring light, and the use of bright light therapy for depressive symptoms has been shown to reduce them in placebo controlled trials. Cognitive behavioral therapy has also been demonstrated to be effective in SAD. This review article aims to focus on the psychopharmacological treatment options for SAD. According to clinical trial results, first line treatment options seem to be sertraline and fluoxetine, and are well tolerated by the patients. There is some evidence that other antidepressants (e.g. bupropion) might be effective as well. Although clinical trials have shown that some of these antidepressants may be of benefit, a recent review has concluded that there is not enough evidence to support the use of any of these agents for the treatment of SAD yet. Moreover, more studies are still needed to evaluate the effectiveness of other treatment options, e.g., propranolol, melatonin, hypericum, etc. In addition to the above proposed treatments, patients with seasonal depressive symptoms should thoroughly be evaluated for any cues of bipolarity, and their treatment should be planned accordingly. © Medicinska naklada - Zagreb, Croatia.

Published
2016

62. A fully functional drug-eluting joint implant

Author

Suhardi, V. J., primary, Bichara, D. A., additional, Kwok, S. J. J., additional, Freiberg, A. A., additional, Rubash, H., additional, Malchau, H., additional, Yun, S. H., additional, Muratoglu, O. K., additional, and Oral, E., additional

Published
2017
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66. THE IMPACT OF DIFFERENT SOWING-TIMES OF THE QUINOA (CHENOPODIUM QUINOA WILLD.) AND ITS VARIETIES ON THE YIELD AND YIELD COMPONENTS IN TURKEY-MARDIN ECOLOGY CONDITION.

Author

ALTUNER, F., ORAL, E., and KULAZ, H.

Subjects
QUINOA, GRAIN yields, ECOLOGY
Abstract

This research was planned to determine the correct sowing times of quinoa (Chenopodium quinoa Willd.) varieties under the ecological conditions of Turkey-Mardin. The study was conducted in three different sowing times (15 March, 30 March and 15 April) using 2 quinoa varieties in aqueous conditions in 2017 spring period with three repetitions. At the end of the research; according to the data obtained, the number of plants in the harvest (15.4- 29.2 plants/m²), plant height (73.9-90.3 cm), the main panicle length (31.1-43.9 cm), the number of panicle branches (23.7-29.7 units plant), thousand weight (3.37-3.46 g), grain yield (125.6-1339 kg ha-1), hectoliter weight (6220-6280 kg ha-1) and crude protein ratio (14.8-15.7%) ranged. The highest grain yield was obtained from the application of Valiente and Titicaca (April 15) with 1345-1333 kg ha-1, respectively. As a result of these properties, it was concluded that the most suitable planting time for quinoa (Chenopodium quinoa Willd.) cultivation in Mardin may be the second week of April. [ABSTRACT FROM AUTHOR]

Published
2019
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67. [Untitled]

Author

Oral, E. Timuçin and Bölüm Yok

Abstract

WOS: 000334575300001 …

Published
2014

69. Erişkin dikkat eksikliği hiperaktivite bozukluğu olan bipolar bozukluk tip-I hastalarının mizaç ve kişilik özellikleri

Author

Oğuz, Nihan, Oral, E. Timuçin, Oğuz, Mehmet, and Bölüm Yok

Subjects
Psikiyatri
Abstract

Amaç: Daha önce yapılan çalışmalarda bipolar I bozuklukta (BPB-I) mizaç ve kişilik araştırılmış, ancak erişkin dikkat eksikliği hiperaktivite bozukluğunun (DEHB) eşlik ettiği BPB-I hastalarında mizaç ve kişilik araştırılmamıştır. Bu çalışmada amaç remisyonda olan BP-I hastalarında DEHB'nin mizaç ve kişilik üzerinde farklılık oluşturup oluşturmadığını kontrol grubu ile karşılaştırarak ortaya koymaktır. Yöntem: BPB-I tanısıyla izlenen hastalar (s121, kadın 71, erkek 50) yaş, cinsiyet ve eğitim açısından eşleştirilmiş, bilinen bir psikiyatrik bozukluğu olmayan kontrol grubu (s100, kadın 55, erkek 45) ile karşılaştırılmıştır. Tüm hastalara ve kontrol grubuna ayrıntılı sosyodemografik form uygulandıktan sonra DSM-IV ölçütlerine göre çocukluk çağı ve erişkin DEHB tanısı ve diğer eksen I tanıları için SCID-I ve SCID-II uygulanmıştır. Tüm hastalar ve kontrol grubuyla erişkin ve çocukluk DEHB tanısı için klinik görüşme yapılmıştır. Hastaların ve kontrol grubunun Erişkin Dikkat Eksikliği Hiperaktivite Ölçeğini doldurmaları istenmiştir. Ayrıca hastaların ve kontrol grubunun TEMPS-A anketini doldurmaları istenmiştir. Bulgular: BPB-I hastalarında %21.7 (s27), kontrol grubunda %7 (s7) oranında erişkin DEHB tanısı konmuştur. Depresif mizaç, saf BPB-I ve erişkin DEHB'nin eşlik ettiği BPB-I hastalarında saf kontrol grubuna göre daha fazla sıklıkta gözlenmiştir. Saf kontrol grubunda hiç ağır şiddette depresif mizaç görülmemiştir. BPB-I ve erişkin DEHB'nin eşlik ettiği BPB-I hastaları arasında depresif mizaç açısından fark bulunamamıştır. Erişkin DEHB'nin eşlik ettiği BPB-I hastalarında hiç hafif şiddette dönem görülmezken, koruyucu tedavi başlangıcı daha erken, koruyucu tedavi süresi daha uzundur. Tüm üç grupta kişilik bozukluğu açısından belirgin bir farklılık gözlenmiştir. Antisosyal kişilik bozukluğu ve şizotipal kişilik bozukluğu sadece erişkin DEHB'nin eşlik ettiği BPB-I hastalarında gözlenmiştir. Sonuç: Erişkin DEHB'nin eşlik ettiği BPB-I hastalarının kliniğinin daha farklı olduğu, bu farkın eşlik eden kişilik bozukluğundan kaynaklanabileceği, bunun da DEHB'nin BPB-I üzerindeki etkisi olabileceği öne sürülebilir Objective: Temperament and personality in bipolar-I (BP-I) patients have been studied but temperament and personality in BP-I patients comorbid with adult attention deficit hyperactivity disorder (ADHD) have not been studied before. The aim of this study was to determine the effect of ADHD on the temperament and personality of BP-I patients in remission. Methods: Patients with a BP-I disorder diagnosis (n121, female 71, male 50) were matched with control group with no known psychiatric illness (n100, female 55, male 45) according to age, sex, education were recruited from consecutive admissions. After the sociodemographic form, SCID-I for childhood and adult ADHD and the other axis-I diagnoses according to DSM-IV criteria and SCID-II have been applied to all patients and control group. All patients were interviewed for the presence and history of current adult and childhood ADHD diagnosis. The subjects also completed the Adult ADD/ADHD DSM-IV Based Diagnostic and Screening Rating Scale Turkish version and the Turkish version of TEMPS-A Scale. Results: Adult ADHD diagnosis were observed in bipolar I patients with 21.7% (n26) and in control group with 7% (n7). Tempera-ment measurements revealed depressive type was found more commonly in the pure BP-I and the comorbid BP-I with adult ADHD group compared to the pure control group. There was no severe depressive temperament in the pure control group. When BP-I and the comorbid BP-I with adult ADHD group were analysed separately for the depressive temperament, there were no difference between the pure BP-I and the comorbid BP-I with adult ADHD group. The the comorbid BP-I with adult ADHD group were observed to have moderate/severe episodes, earlier and longer maintenance treatment periods. All three groups differ in terms of personality disorder. Antisocial personality disorder and schizotypal personality disorder were observed only in the comorbid BP-I with adult ADHD group. Conclusion: BP-I disorder comorbid with adult ADHD has significant clinical implications which may relate to a personality disorder. This may be due to the influence of ADHD on BP-I disorder

Published
2014

73. Constraining the point source parameters of the 11 November 2019 Mw 4.9 Le Teil earthquake using multiple relocation approaches, first motion and full waveform inversions

Author

Delouis, Bertrand, Oral, Elif, Menager, Marine, Ampuero, Jean-Paul, Guilhem Trilla, Aurélie, Régnier, Marc, and Deschamps, Anne

Subjects
Relative location, Le Teil earthquake, Master event, Focal mechanism, Earthquake location, Waveform inversion, Geophysics. Cosmic physics, QC801-809, Chemistry, QD1-999, Geology, QE1-996.5
Abstract

The point source parameters of the 11 November 2019 Le Teil earthquake (Mw 4.9) in France are revisited. Previous hypocenter determinations either located it on the wrong side of the causative fault, or had to restrain the depth ranges to obtain epicenters compatible with the fault geometry. Here, relocation is carried out with three different approaches: (1) using as a master event an aftershock well-recorded by the post-earthquake temporary seismic network; (2) optimizing the velocity model in two subareas; and (3) using a quarry blast. All three approaches concur in a common epicentral area located in the middle of the rupture, confirming its bilateral character. Hypocentral depth is best constrained at $1.5 \pm 0.5~\mathrm{km}$, a range confirmed by waveform inversion. The dip of the SE-dipping nodal plane corresponding to the fault is not well constrained by waveform inversion, but the focal mechanism at rupture initiation determined with the first motions suggests that fault dip may be constant (50°–60°) from the surface down to 1–1.5 km depth. Optimized velocity models point to a strong velocity contrast, mainly in the $V_p/V_s$ ratio, between the NW and the SE sides of the Cevennes fault system, which clearly correlates with the geology.

Published
2021
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74. Polycystic Kidney Disease in a Patient Using Lithium Chronically

Author

Murat İlhan Atagün, Oral, E. T., and Sevinç, C.

Abstract

Lithium remains to be the gold standard in the treatment of mood disorders. This study presents a case treated with lithium for an extended period with a good response. Following an increase in creatinine levels, further investigation of renal dysfunction revealed polycystic kidney disease. Lithium was used prior to the diagnosis of polycystic kidney disease, resulting in the unique opportunity to examine the effects of lithium on kidneys with polycystic kidney disease. Within this context, this study also discusses the pharmacokinetics of lithium, and its possible relation to cyst formation in polycystic kidney disease.

Published
2013

75. CLINICAL POTENTIAL OF CARIPRAZINE IN THE TREATMENT OF ACUTE MANIA

Author

Altınbaş, Kürşat, Gülöksüz, Sinan, Oral, E. Timuçin, and Bölüm Yok

Subjects
Antipsychotic, Mania, Clinical Trials as Topic, Bipolar Disorder, Bipolar disorder, Psychopharmacology, Acute Disease, Animals, Humans, Cariprazine, cariprazine – antipsychotic – psychopharmacology - bipolar disorder - mania, Piperazines, Antipsychotic Agents
Abstract

PubMed ID: 24048386 Cariprazine (RGH-188, trans-4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]- ethyl}-N,N-dimethylcarbamoyl-cyclohexyl-Amine hydrochloride), is a novel antipsychotic with dopamine D2 and D3 receptors antagonist-partial agonist properties. Cariprazine has also moderate affinity for serotonin 5-hydroxytryptophan (5-HT) 1A receptors, high affinity for 5-HT1B receptors with pure antagonism and low affinity for 5-HT2A receptors. Randomized, double blind, placebo controlled, flexible-dose (3-12 mg/day) studies have demonstrated cariprazine is effective in both schizophrenia and acute manic episodes associated with bipolar disorder. The incidence of serious adverse events in cariprazine arm was no different than in placebo arm in these studies. The most common adverse events were extrapyramidal symptoms, headache, akathisia, constipation, nausea, and dyspepsia which can be explained with cariprazine's partial dopamine agonism. Although cariprazine treatment was associated with a higher incidence of treatmentemergent adverse events, particularly akathisia and tremor, common side effects of marketed second generation antipsychotics such as weight gain, metabolic disturbances, prolactin increase or QTc prolongation were not associated with cariprazine, probably due to its moderate to low binding affinity for histamine H1 and 5-HT2C receptors. Animal studies show that cariprazine may have additional therapeutic benefit on impaired cognitive functioning with D3 receptor activity, however clinical data is still scarce. The aim of this article is to review the potential use of cariprazine for the treatment of acute manic episodes in the light of the preclinical and clinical trials reported to date. © Medicinska naklada - Zagreb, Croatia.

Published
2013

76. Reliability and validity of Turkish version of biological rhythms interview of assessment in neuropsychiatry

Author

Aydemir, Ömer, Altınbaş, Kürşat, Kora, Kaan, Suculluoğlu, Didem Dikici, Akdeniz, Fatma, Kalaycı, Fatma, Oral, E. Timuçin, Vahip, Simavi, Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı., and Akkaya, Cengiz

Subjects
Bipolar disorder, Biological rhythms interview of assessment in neuropsychiatry, Pittsburgh sleep quality index, Mood disorder, Receiver operating characteristic, Item total correlation, Major clinical study, Article, Concurrent validity, Validity, Cronbach alpha coefficient, Duygudurum bozuklukları, Bipolar I disorder, Psychiatry, Bipolar Disorder, Actimetry, Slow Wave Sleep, Circadian rhythm, Depression, Biyolojik ritim değerlendirme görüşmesi, Güvenilirlik, Reliability, Bipolar II disorder, Geçerlilik, Internal consistency, Clinical assessment tool, Mood disorders, Controlled study, Human
Abstract

Bu çalışmanın amacı Biyolojik Ritim Değerlendirme Görüşmesinin (BRDG) Türkçe sürümünün güvenilirlik ve geçerliliğini ortaya koymaktır. Yöntem: Araştırma üç üniversite hastanesi psikiyatri anabilim dalı ve bir eğitim hastanesi duygudurum bozuklukları birimlerine başvuran ve iki uçlu tip I bozukluk tanısı konan 79, iki uçlu tip II bozukluk tanısı konan 26, majör depresif bozukluk tanısı konan 42 hasta ile, üniversite öğrencilerinden oluşan 116 sağlıklı gönüllüden oluşan gruplarla yürütülmüştür. Hastalık süresi iki uçlu bozukluk grupları için 15.1 yıl ve majör depresif bozukluk grubu için 9.3 yıldır. Birlikte geçerliliği değerlendirmek amacıyla Pittsburgh Uyku Kalitesi Ölçeği uygulanmıştır. İstatistiksel değerlendirmede iç tutarlılık katsayısı, madde-toplam puan bağıntı katsayıları, açıklayıcı ve doğrulayıcı faktör çözümlemesi, diğer ölçekle bağıntı ve ROC eğrisi hesaplanmıştır. Bulgular: BRDG önce Türkçeye, sonra İngilizceye çevrilmiş ve çeviriler sonunda dil birliğiyle ölçek metni elde edilmiştir. İç tutarlılık çözümlemesinde Cronbach alfa katsayısı 0.899 ve madde-toplam puan bağıntı katsayıları 0.239-0.747 arasında elde edilmiştir. Açıklayıcı faktör çözümlemesinde varyansın %56.5‟ini açıklayan toplam üç faktör elde edilmiştir: Günlük etkinlikler, uyku ve yeme alışkanlıkları, kişilerarası ilişkiler. Doğrulayıcı faktör çözümlemesinde karşılaştırmalı uyum endeksi 0.932 ve tahminin ortalama kare kök hatası 0.065 olarak bulunmuştur. BRDG‟nin Pittsburgh Uyku Kalitesi Ölçeği ile bağıntısı r=0.238 olarak hesaplanmıştır. Özgüllük ve duyarlılık çözümlemesinde ROC eğrisinin altında kalan alan 0.876 olarak bulunmuştur. Ölçeğin duygudurum bozukluğu gruplarını kontrol grubundan ayırt ettiği görülmüştür. Sonuç: Hastaların günlük döngüsel ritmini ve bu ritime uygun olarak işlevselliğini değerlendirmeye elverişli BRDG‟nin Türkçe formunun güvenilir ve geçerli olduğu gösterilmiştir. Objective: In this study, it is aimed to perform the validity and reliability of the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry. Methods: The study was performed with 79 bipolar type-I disorder, 26 bipolar type-II disorder and 42 major depressive disorder patients attending to mood disorder clinics of three university hospitals and one state training hospital as well as 116 university students consisting healthy control subjects. The mean duration of the illness was 15.1 years for the bipolar groups and 9,3 years for the depressive group. For concurrent validity, Pittsburgh Sleep Quality Index was used. In the statistical analyzes, internal consistency coefficient, item-total score correlations, exploratory and confirmatory factor analyzes, correlation with the other scale and ROC curve were calculated. Results: The forward and back translation of the Biological Rhythms Interview of Assessment in Neuropsychiatry was performed, and linguistic equivalence was obtained with the scale prepared. In internal consistency, the Cronbach's alpha coefficient was found to be 0.899 and item-total correlation coefficients were between 0.239 and 0.747. In the exploratory factor analysis, a total of three factors representing 56.5% of the total variance were obtained and the themes of the factors were daily activities, sleep and eating habits and interpersonal relations. In the confirmatory factor analysis, confirmatory fit index was 0.932 and root mean square of approximation was 0.065. The correlation between Biological Rhythms Interview of Assessment in Neuropsychiatry and Pittsburgh Sleep Quality Index was found to be r=0.238. In the sensitivity and specificity analysis, the area under the ROC curve was 0.876. The scale discriminated mood disorder groups from the healthy control group. Conclusion: It is shown that the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry which is used in the assessment of circadian rhythm and functionality is reliable and valid.

Published
2012

81. Improving the limit of detection (LOD) of microsensor used in detection of brain diseases via wavelet filter

Author

Koc, Hilal, primary, Kadihasanoglu, Gulsah, additional, Geyikoglu, M. Dilruba, additional, Dertli, M. Emin, additional, Cavusoglu, Bulent, additional, Ozbek, I. Yucel, additional, Oral, E. Argun, additional, Hacimuftuoglu, Ahmet, additional, Sonmez, Erdal, additional, Karacali, Tevhit, additional, Ertugrul, Mehmet, additional, and Efeoglu, Hasan, additional

Published
2015
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84. Simultaneous removal of indomethacine, papaverine and allopurinol from aqueous solution by using submerged aquatic plant nasturtium officinale

Author

Veysi Okumuş, Oral, E., Basaran, D., Onay, A., Fen - Edebiyat Fakültesi, and Okumuş, Veysi

Subjects
HPTLC, Indomethacine, Papaverine, Allopurinol, Biosorption, Submerged aquatic plant, Nasturtium officinale
Abstract

Simultaneous removal of indomethacine, papaverine and allopurinol from aqueous solution by using submerged aquatic plant Nasturtium officinale biomass in high performance thin layer chromatography (HPTLC) was studied. Optimum biosorption conditions were determined as a function of contact time, pH, removal capacity of the amount of biomass and initial dry concentration. Experiments were performed in batch conditions. Concentrations of the drugs in the remaining solutions were simultaneously analyzed by HPTLC. Langmuir and Freundlich models were applied to describe the biosorption isotherm of the drugs by aquatic plant Nasturtium officinale biomass. According to the results, optimum parameters were found as 2.0 g biomass, pH:5.0 and 60 min contact time. Obtained from plots of Langmuir and Freundlich adsorption models, the highest drug uptakes were calculated from Langmuir isotherm and found to be 43.10, 39.68 and 38.61 mg/g for indomethacine, papaverine and allopurinol, respectively.

Published
2010

85. Bipolar bozuklukla ilgili genetik araştırmalar: Bir gözden geçirme

Author

Arısoy, Özden, Oral, E. Timuçin, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Arısoy, Özden

Subjects
Association, Genetic, Linkage, Assosiasyon, Bipolar, Bağlantı, Kromozom, Genetik, Chromosome
Abstract

Bipolar Bozukluk (BPB), toplumun yaklaşık % 1'ini etkileyen, manik ve depresif dönemlerle seyreden bir rahatsızlıktır. BPB'un nedeni halen tam olarak aydınlatılamamış olmakla birlikte; BPB'ta genetik faktörlerin merkezi bir rolü olduğu bilinmektedir. Bugüne kadar BPB ile ilgili pek çok araştırma yapılmış olup, BPB'un genetik yatkınlığına dair ilk veriler genetik epidemiyolojik araştırmalardan (aile, ikiz, evlat edinme çalışmaları) elde edilmiştir. Daha sonraları yapılan moleküler genetik araştırmalar da bu epidemiyolojik verileri desteklemiş ve pek çok kromozomal bölge BPB ile bağlantılı bulunmuştur ancak bozukluğa yol açan tek bir gen henüz saptanabilmiş değildir. Bunun nedeni, BPB'ta birden fazla genin çevre faktörleriyle etkileşimi sonucunda rahatsızlığın ortaya çıkması olup, bütün bu veriler BPB'un karmaşık bir genetiği olduğunu göstermiştir. Bu yazıda, BPB'un genetik temelleri ile ilgili bugüne kadar yapılmış araştırmaları gözden geçirmek amacıyla medline veri tabanında Türkçe karşılıkları "bipolar, genetik, kromozom" olan anahtar kelimeler ile literatür taraması yapılmış ve öncelikle pozitif sonuç elde edilen çalışmalar ele alınarak bu çalışmalarda bulunan sonuçlar sistematik olarak gözden geçirilmiş ve her bir kromozom için tek tek özetlenmiş, elde edilen bulguların niçin birbirini desteklemediğine kısaca değinilmiş ve bundan sonra yapılması düşünülen genetik araştırmalarda hangi noktalara dikkat edilmesi gerektiğinden bahsedilmiştir. Bipolar disorder is a severe mental illness that afflicts approximately 1% of the world's population, and is characterized by mood swings from elation to depression. Although the etiology of bipolar disorder remains unclear, heritable factors have been shown to be involved. Family, twin, and adoption studies suggest a genetic etiology. Molecular genetic studies also support a genetic component. Many chromosomal regions have been implicated by these molecular genetic studies, but no single susceptibility gene has been identified. These findings show that bipolar disorder has a complex genetic etiology in which multiple unidentified genes and environmental factors play an important role in its pathogenesis. Herein, molecular genetic studies of bipolar disorder are reviewed based on a search of Medline using the key words, bipolar, genetic, and chromosome. Studies with positive results for bipolar disorder were selected first. The findings from these molecular genetic studies are reviewed systematically, chromosome by chromosome. Causes of the differences between the reported findings and of non-replication are discussed. Finally, important factors for designing a genetic study of bipolar disorder are examined.

Published
2009

86. Rapid response to the M$_{\protect \rm w}$ 4.9 earthquake of November 11, 2019 in Le Teil, Lower Rhône Valley, France

Author

Cornou, Cécile, Ampuero, Jean-Paul, Aubert, Coralie, Audin, Laurence, Baize, Stéphane, Billant, Jérémy, Brenguier, Florent, Causse, Mathieu, Chlieh, Mohamed, Combey, Andy, de Michele, Marcello, Delouis, Bertrand, Deschamps, Anne, Ferry, Matthieu, Foumelis, Michalis, Froment, Bérénice, Gélis, Céline, Grandin, Raphaël, Grasso, Jean-Robert, Hannouz, Estelle, Hok, Sébastien, Jung, Axel, Jolivet, Romain, Langlais, Mickaël, Langlaude, Philippe, Larroque, Christophe, Leloup, Philippe Hervé, Manchuel, Kevin, Marconato, Léo, Maron, Christophe, Mathot, Emmanuel, Maufroy, Emeline, Mercerat, Diego, Metois, Marianne, Nayman, Emmanuelle, Pondaven, Ildut, Provost, Ludmila, Régnier, Julie, Ritz, Jean-François, Rivet, Diane, Schlupp, Antoine, Sladen, Anthony, Voisin, Christophe, Walpersdorf, Andrea, Wolynieck, David, Allemand, Pascal, Beck, Elise, Bertrand, Etienne, Bertrand, Véronique, Briole, Pierre, Brunel, Didier, Cavalié, Olivier, Chèze, Jérôme, Courboulex, Françoise, Douste-Bacque, Isabelle, Dretzen, Rémi, Giampietro, Tiziano, Godano, Maxime, Grandjean, Philippe, Grunberg, Marc, Guerin, Gauthier, Guillot, Stéphane, Haber, Elias El, Hernandez, Alain, Jomard, Hervé, Lasserre, Cécile, Liang, Chao, Lior, Itzhak, Martin, Xavier, Mata, Daniel, Menager, Marine, Mercier, Antoine, Mordret, Aurélien, Oral, Elif, Paul, Anne, Peix, Fabrice, Pequegnat, Catherine, Pernoud, Michel, Satriano, Claudio, Sassi, Rihab, Schaming, Marc, Sellier, Valérie, Sira, Christophe, Socquet, Anne, Sue, Christian, Trilla, Aurélie, Vallée, Martin, van den Ende, Martijn, Vernant, Philippe, Vial, Benjamin, and Weng, Huihui

Subjects
Le Teil earthquake, Rhône valley, Seismic sequence, Post-seismic, Surface rupture, InSAR interferometry, Geophysics. Cosmic physics, QC801-809, Chemistry, QD1-999, Geology, QE1-996.5
Abstract

On November 11, 2019, a M$_{\mathrm{w}}$ 4.9 earthquake hit the region close to Montelimar (lower Rhône Valley, France), on the eastern margin of the Massif Central close to the external part of the Alps. Occuring in a moderate seismicity area, this earthquake is remarkable for its very shallow focal depth (between 1 and 3 km), its magnitude, and the moderate to large damages it produced in several villages. InSAR interferograms indicated a shallow rupture about 4 km long reaching the surface and the reactivation of the ancient NE–SW La Rouvière normal fault in reverse faulting in agreement with the present-day E–W compressional tectonics. The peculiarity of this earthquake together with a poor coverage of the epicentral region by permanent seismological and geodetic stations triggered the mobilisation of the French post-seismic unit and the broad French scientific community from various institutions, with the deployment of geophysical instruments (seismological and geodesic stations), geological field surveys, and field evaluation of the intensity of the earthquake. Within 7 days after the mainshock, 47 seismological stations were deployed in the epicentral area to improve the Le Teil aftershocks locations relative to the French permanent seismological network (RESIF), monitor the temporal and spatial evolution of microearthquakes close to the fault plane and temporal evolution of the seismic response of 3 damaged historical buildings, and to study suspected site effects and their influence in the distribution of seismic damage. This seismological dataset, completed by data owned by different institutions, was integrated in a homogeneous archive and distributed through FDSN web services by the RESIF data center. This dataset, together with observations of surface rupture evidences, geologic, geodetic and satellite data, will help to unravel the causes and rupture mechanism of this earthquake, and contribute to account in seismic hazard assessment for earthquakes along the major regional Cévenne fault system in a context of present-day compressional tectonics.

Published
2021
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88. Reliability and Validity Study of The Turkish Version of Hypomania Checklist-32-Revised.

Author

VAHİP, Simavi, AYDEMİR, Ömer, AKKAYA, Cengiz, ALTINBAŞ, Kürşat, KORA, Kaan, SÜCÜLLÜOĞLU DİKİCİ, Didem, AKDENİZ, Fatma, KALAYCI, Fatma, ORAL, E. Timuçin, VAHİP, Işıl, ALKAN, Müge, and ANGST, Jules

Subjects
HYPOMANIA, RELIABILITY (Personality trait), IMPULSE (Psychology), SENSITIVITY (Personality trait), EXPLORATORY factor analysis, DIAGNOSIS
Abstract

Objective: In this study, we aimed to evaluate the reliability and validity of the Turkish version of Hypomania Checklist-32-Revised. Method: The study was carried out with 80 patients diagnosed with bipolar I disorder, 26 patients diagnosed with bipolar II disorder and 42 patients diagnosed with major depressive disorder attending the out- and in-patient psychiatry departments of three university hospitals and one training hospital and 116 healthy volunteers consisting of university students. Mean duration of illness was 15.1 years for the bipolar disorder group and 9.3 years for the major depressive disorder group. For concurrent validity, the Mood Disorder Questionnaire was used. In the statistical analysis, internal consistency coefficient, item-total score correlation coefficients, exploratory factor analysis, correlation with concurrent scale and ROC curve were calculated. Results: Translation into Turkish and back-translation into English of Hypomania Checklist-32-Revised were performed and thus the semantic harmony of the scale was obtained. In the internal consistency, Cronbach alpha coefficient was 0.914 and item-total score correlations were between 0.235-0.743. Unlike the rest, the coefficient of item #23 was found as 0.110. In factor analysis, six factors were obtained; however, a two-factor solution representing 44.5% of the total variance was accepted whereas the first factor represents overactivity and being expansive, where the second factor represents impulsivity and risky behaviors. Correlation of Hypomania Checklist-32-R with Mood Disorder Questionnaire was r=0.379. In the ROC analysis, the cutoff point of the scale was calculated as 14 with a sensitivity of 71.0 and specificity of 69.8. The scale discriminates well between the bipolar group, depressive and control groups. Conclusion: Hypomania Checklist-32-Revised developed for screening hypomania is reliable and valid in Turkish after exclusion of item #23. [ABSTRACT FROM AUTHOR]

Published
2017
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91. Yurt dışından dönen Türk öğrencilerin uyum düzeyleri ve benlik algıları

Author

AKBALIK, F. Gül, KARADUMAN, B. Dilek, ORAL, E. Arzu, and ÖZDOĞAN, Belka

Subjects
education, High-school,adaptation,school adaptation,self-perception,academic performance,foreign country,Turkish students
Abstract

This study examines the adaptation and self perception level differences between the Turkish students who had been and not been in a foreign country. A total of 299 students, attending three different Anatolian high schools, participated in the study. Three groups of students were compared; the first group had come from abroad within a year, the second group had come more than a year ago and the third group had not been in a foreign country. The results demonstrated that there were no differences between the group's Total, Social Adjustment Subscale and Academic Adjustment Subscale scores. The exception for this were the fırst group, who scored lower on School Adaptation Subscale of the Adjustment Scale than those of the other two groups. Additionally, It was found that the third group scored higher on only one of the six sub-scales of the Piers-Harris' Self Concept Scale, namely the Cognitive and Academic Performance Subscale from the other two groups

Published
2003

92. Effect of different types of intrauterine devices on intrauterine activity

Author

Sahmay, S, Kaleli, S, Oral, E, Alper, T, Unal, O, Karacan, I, Atasu, T, and Ondokuz Mayıs Üniversitesi

Subjects
intrauterine activity (IUA), side effects, copper-T, intrauterine device (IUD), multiload
Abstract

WOS: 000081430000005 PubMed: 10435914 Objective-To compare the effects of various IUDs on intrauterine activity. Patients and Methods-57 women volunteers aged 18 to 25 in the outpatient clinic of the Department of Obstetrics and Gynecology at Cerrahpasa Medical Faculty of Istanbul University were included in the study. All were in good health and menstruating normally. The subjects were introduced to different types of IUDs on the fifth to eighth days of their menstrual cycle. Intrauterine activities with and without naproxen were recorded, for at least 20 minutes-each time, with a micro-tip transducer before insertion, lust after insertion, and 1 month later. Results-Intrauterine activity increased lust after insertion of both IUDs and disappeared 1 month later in copper-T wearing women, but persisted in multiload wearers. Naproxen seemed to be useful in preventing intrauterine activity caused by the IUD. Conclusions-The IUD itself causes an increase in intrauterine activity which is preventable by naproxen, suggesting the possible role of prostaglandins. Persistence of intrauterine activity depends upon the type of device. Optimal designing of IUDs is required to decrease side effects and make them more acceptable.

Published
1999

93. PSİKOSOSYAL BOYUTLARI İLE BAZI KRİZ OLGULARI

Author

ORAL E., Arzu

Subjects
Krize müdahale,toplumsaldeğişim, Crisis intervention,social change
Abstract

Issues on mental health and social changes were taken into consideration by the cases who applied Crisis Intervention Center. Especially social changes and motives were presented by the effects on individual and his/her relations., Ruh Sağlığı ve toplumsal değişim konuları, Kriz Merkezi'ne başvuran bazı olgular üzerinden ele alınmış, özellikle bireye ve ilişkilerine yansıyan yönüyle aktarılmaya çalışılmıştır.

Published
1998

99. KRİZ OLGULARINDA AİLE İÇİNDE YAŞANAN ŞİDDET

Author

ORAL E., Arzu, BİNİCİ, Semra A, BÜYÜKÇELİK, Dilek, and YAZAR, Ö. Hülya

Subjects
Aile,kriz,şiddet,kadın, Family,crisis,violence,vvoman
Abstract

Summary: It's knovvn that the women are exposed to violence in the family. This result is supported by both clinical experiences and rescarches. İis mentioned that the person who used violence and the person who is exposed to violence have some characteristics. İn this study, it is investigated the patients who are exposed to violence from between married patients have applicated tho Crisis Center in 1996. Ali of them are vvomen and are exposed to bad langage, Majority of applications have exposed to violence in the first years of marriage. İn the paper, two cases are discussed in the light of these characteristics., Özet: Aile içindeki şiddetin daha çok kadınlara yönelik olduğu hem yapılan çalışmalarda hem de klinik uygulamalarda gözlenmektedir. Çalışmalarda şiddeti uygulayan ve şiddete maruz kalanların belirli bir takım özelliklere sahip oldukları da belirtilmektedir. Bu çalışmada 1996 yılında Kriz Merkezi'ne çeşitli şikayetlerle başvuranlar arasından, öyküsünde şiddet olan evli müracaatçılar ele alınmış; özellikleri retrospektif olarak incelenmiştir. Sonuç olarak ele alınan hemen her vak'ada saptanan özellikler, bu müracaatçıların hepsinin kadın olduğu ve şiddete evlilik öncesi tanışma süresi de dahil ilk yıllarda maruz kaldıkları, fiziksel şiddet yanında sözel şiddetin de yer aldığıdır. Çalışmada iki örnek vak'a bu özellikler açısından tartışılmıştır.

Published
1997

100. Anti-inflammatory effects of troglitazone in nondiabetic obese subjects independent of changes in insulin sensitivity.

Author

Tits, L.J.H. van, Arioglu-Oral, E., Sweep, C.G.J., Smits, P., Stalenhoef, A.F.H., Tack, C.J.J., Tits, L.J.H. van, Arioglu-Oral, E., Sweep, C.G.J., Smits, P., Stalenhoef, A.F.H., and Tack, C.J.J.

Abstract

Contains fulltext : 48530.pdf (publisher's version ) (Closed access), BACKGROUND: Obesity is characterised by insulin resistance and by elevated levels of proinflammatory markers. We investigated whether, in the absence of changes in glucose, thiazolidinediones (TZDs) have anti-inflammatory effects and whether improvement of insulin sensitivity correlates with suppression of inflammatory markers. METHODS: We performed a randomised double-blind placebo-controlled crossover study with troglitazone (400 mg daily for eight weeks) in 15 normoglycaemic obese subjects. We measured plasma high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), leptin, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and tumour necrosis factor-alpha (TNF-alpha) after each of the two treatment periods and in 13 age- and sex-matched lean individuals. RESULTS: Obese subjects were insulin resistant (decreased glucose infusion rate (GIR) during euglycaemic hyperinsulinaemic clamp) and had higher plasma levels of hsCRP, IL-6, leptin, tPA, and PAI-1 compared with lean subjects. TNF-alpha also tended to be higher. Troglitazone improved insulin sensitivity (mean increase in whole body glucose uptake 23.1 +/- 10.5% (p = 0.047)) and normalised plasma concentrations of hsCRP, tPA and TNF-alpha, whereas it did not significantly change IL-6, leptin and PAI-1. Changes in GIR did not correlate with changes in inflammatory markers. CONCLUSION: Troglitazone induces suppression of some of the inflammatory markers that are elevated in normoglycaemic obese subjects. The suppression of inflammatory markers, however, does not correlate with improvement in insulin sensitivity, suggesting involvement of partially differential mechanisms in these effects of TZDs.

Published
2005

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