Author: "Onodera, Masafumi" - Searchworks@Jio Institute Digital Library Search Results

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532 results on '"Onodera, Masafumi"'

51. Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome

Author: Oka, Yasuyoshi, primary, Hamada, Motoharu, additional, Nakazawa, Yuka, additional, Muramatsu, Hideki, additional, Okuno, Yusuke, additional, Higasa, Koichiro, additional, Shimada, Mayuko, additional, Takeshima, Honoka, additional, Hanada, Katsuhiro, additional, Hirano, Taichi, additional, Kawakita, Toshiro, additional, Sakaguchi, Hirotoshi, additional, Ichimura, Takuya, additional, Ozono, Shuichi, additional, Yuge, Kotaro, additional, Watanabe, Yoriko, additional, Kotani, Yuko, additional, Yamane, Mutsumi, additional, Kasugai, Yumiko, additional, Tanaka, Miyako, additional, Suganami, Takayoshi, additional, Nakada, Shinichiro, additional, Mitsutake, Norisato, additional, Hara, Yuichiro, additional, Kato, Kohji, additional, Mizuno, Seiji, additional, Miyake, Noriko, additional, Kawai, Yosuke, additional, Tokunaga, Katsushi, additional, Nagasaki, Masao, additional, Kito, Seiji, additional, Isoyama, Keiichi, additional, Onodera, Masafumi, additional, Kaneko, Hideo, additional, Matsumoto, Naomichi, additional, Matsuda, Fumihiko, additional, Matsuo, Keitaro, additional, Takahashi, Yoshiyuki, additional, Mashimo, Tomoji, additional, Kojima, Seiji, additional, and Ogi, Tomoo, additional
Published: 2020
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52. Chromosomal Translocation t(11;14) Induced By the Cre-Loxp System in Normal B Cell-Derived Ips Cells for the Study of Myeloma-Initiating Cells

Author: Sugai, Misaki, primary, Tsuyama, Naohiro, additional, Abe, Yu, additional, Azami, Yusuke, additional, Kudo, Kenichi, additional, Ota, Akinobu, additional, Karnan, Sivasundaram, additional, Muramatsu, Moe, additional, Shigemura, Tomonari, additional, Sasatani, Megumi, additional, Hashimoto, Yuko, additional, Kamiya, Kenji, additional, Hanamura, Ichiro, additional, Ikezoe, Takayuki, additional, Onodera, Masafumi, additional, and Sakai, Akira, additional
Published: 2020
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53. Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus

Author: Yamanaka, Ryuya, Zullo, Susan A, Ramsey, Jay, Onodera, Masafumi, Tanaka, Ryuichi, Blaese, Michael, and Xanthopoulos, Kleanthis G
Published: 2001
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54. Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance

Author: Kawano, Yoshinaga, Nakae, Jun, Watanabe, Nobuyuki, Fujisaka, Shiho, Iskandar, Kristy, Sekioka, Risa, Hayashi, Yoshitake, Tobe, Kazuyuki, Kasuga, Masato, Noda, Tetsuo, Yoshimura, Akihiko, Onodera, Masafumi, and Itoh, Hiroshi
Published: 2012
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55. A Distinct Feature of T Cell Subpopulations in a Patient with CHARGE Syndrome and Omenn Syndrome

Author: Uchiyama, Toru, primary, Kawakami, Saori, additional, Masuda, Hiroshi, additional, Yoshida, Kazue, additional, Niizeki, Hironori, additional, Mochizuki, Emi, additional, Edasawa, Kaori, additional, Ishiguro, Akira, additional, and Onodera, Masafumi, additional
Published: 2020
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56. Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan

Author: Yamaguchi, Teruhide, primary, Uchida, Eriko, additional, Okada, Takashi, additional, Ozawa, Keiya, additional, Onodera, Masafumi, additional, Kume, Akihiro, additional, Shimada, Takashi, additional, Takahashi, Satoru, additional, Tani, Kenzaburo, additional, Nasu, Yasutomo, additional, Mashimo, Tomoji, additional, Mizuguchi, Hiroyuki, additional, Mitani, Kohnosuke, additional, and Maki, Kazushige, additional
Published: 2020
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57. Bacillus Calmette-Guérin (BCG) Infections at High Frequency in Both AR-CGD and X-CGD Patients Following BCG Vaccination

Author: Ishikawa, Takashi, primary, Okai, Masashi, additional, Mochizuki, Emi, additional, Uchiyama, Toru, additional, Onodera, Masafumi, additional, and Kawai, Toshinao, additional
Published: 2020
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58. A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers

Author: Kataura, Tetsushi, primary, Tashiro, Etsu, additional, Nishikawa, Shota, additional, Shibahara, Kensuke, additional, Muraoka, Yoshihito, additional, Miura, Masahiro, additional, Sakai, Shun, additional, Katoh, Naohiro, additional, Totsuka, Misato, additional, Onodera, Masafumi, additional, Shin-Ya, Kazuo, additional, Miyamoto, Kengo, additional, Sasazawa, Yukiko, additional, Hattori, Nobutaka, additional, Saiki, Shinji, additional, and Imoto, Masaya, additional
Published: 2020
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59. Introduction of Chromosomal Translocation t(11; 14) and a p53 Deletion into Normal B Cell-Derived iPSCs to Elucidate the Cellular Origin of Myeloma Cells

Author: Yanagi, Aki, primary, Tsuyama, Naohiro, additional, Sugai, Misaki, additional, Abe, Yu, additional, Azami, Yusuke, additional, Yanai, Yukari, additional, Ota, Akinobu, additional, Sivasundaram, Karnan, additional, Muramatsu, Moe, additional, Shigemura, Tomonari, additional, Sasatani, Megumi, additional, Hashimoto, Yuko, additional, Kamiya, Kenji, additional, Hanamura, Ichiro, additional, Ikezoe, Takayuki, additional, Onodera, Masafumi, additional, and Sakai, Akira, additional
Published: 2019
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60. Phosphodiesterase III Inhibition Promotes Differentiation and Survival of Oligodendrocyte Progenitors and Enhances Regeneration of Ischemic White Matter Lesions in the Adult Mammalian Brain

Author: Miyamoto, Nobukazu, Tanaka, Ryota, Shimura, Hideki, Watanabe, Terubumi, Mori, Hideo, Onodera, Masafumi, Mochizuki, Hideki, Hattori, Nobutaka, and Urabe, Takao
Published: 2010
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61. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

Author: Sanada, Masashi, Suzuki, Takahiro, Shih, Lee-Yung, Otsu, Makoto, Kato, Motohiro, Yamazaki, Satoshi, Tamura, Azusa, Honda, Hiroaki, Sakata-Yanagimoto, Mamiko, Kumano, Keiki, Oda, Hideaki, Yamagata, Tetsuya, Takita, Junko, Gotoh, Noriko, Nakazaki, Kumi, Kawamata, Norihiko, Onodera, Masafumi, Nobuyoshi, Masaharu, Hayashi, Yasuhide, Harada, Hiroshi, Kurokawa, Mineo, Chiba, Shigeru, Mori, Hiraku, Ozawa, Keiya, Omine, Mitsuhiro, Hirai, Hisamaru, Nakauchi, Hiromitsu, Koeffler, Phillip H., and Ogawa, Seishi
Published: 2009
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62. The induction of tumor-specific CD4+ T cells via major histocompatibility complex class II is required to gain optimal anti-tumor immunity against B16 melanoma cell line in tumor immunotherapy using dendritic cells

Author: Fujisawa, Yasuhiro, Nabekura, Tsukasa, Nakao, Tomohei, Nakamura, Yasuhiro, Takahashi, Takenori, Kawachi, Yasuhiro, Otsuka, Fujio, and Onodera, Masafumi
Published: 2009
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63. Bacillus Calmette-Guérin (BCG) Infections at High Frequency in Both AR-CGD and X-CGD Patients Following BCG Vaccination.

Author: Ishikawa, Takashi, Okai, Masashi, Mochizuki, Emi, Uchiyama, Toru, Onodera, Masafumi, and Kawai, Toshinao
Subjects: INFECTION prevention, CHRONIC disease treatment, GRANULOMA, IMMUNIZATION, GENETIC mutation, CHRONIC diseases, RETROSPECTIVE studies, MEDICAL protocols, BCG vaccines, SYMPTOMS, AGE factors in disease, FAMILY history (Medicine)
Abstract: Background Patients with chronic granulomatous disease (CGD) develop severe infections, including Bacillus Calmette-Guérin (BCG). Although the autosomal recessive CGD (AR-CGD) patients should hypothetically develop relatively fewer infections compared to the X-linked CGD (X-CGD) patients due to more residual reactive oxygen intermediates, the impacts of BCG vaccination on AR-CGD and X-CGD patients are unclear. Herein, we demonstrated the clinical features of BCG infections, treatments, and genetic factors in CGD patients after BCG vaccination under the Japanese immunization program. Methods We collected data retrospectively from 43 patients with CGD and assessed their history of initial infection, age at diagnosis of CGD, BCG vaccination history, clinical course, treatment for BCG infections, and genetic mutations associated with CGD. Results Fourteen CGD patients avoided BCG vaccination because of other preceding infections and family history. Of 29 patients with CGD who received BCG vaccination, 20 patients developed BCG infections. Although the age at onset of initial infection in X-CGD patients was significantly younger than that in AR-CGD patients (P < .01), the onset and frequency of BCG infections were similar in X-CGD and AR-CGD patients. In X-CGD patients, BCG infections equally developed in the patients carrying missense, insertion, deletion, nonsense, and splice mutations of CYBB. All CGD patients with BCG infections were successfully treated with anti-tuberculous drugs. Conclusions Although X-CGD patients develop severe infections at a younger age than AR-CGD patients, our data suggested that BCG infections develop at high frequency in both AR-CGD and X-CGD patients, regardless of genotype and mutant forms. [ABSTRACT FROM AUTHOR]
Published: 2021
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64. A new red fluorescent protein that allows efficient marking of murine hematopoietic stem cells

Author: Sanuki, Seiko, Hamanaka, Sanae, Kaneko, Shin, Otsu, Makoto, Karasawa, Satoshi, Miyawaki, Atsushi, Nakauchi, Hiromitsu, Nagasawa, Toshiro, and Onodera, Masafumi
Published: 2008
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65. 20. TOWARDS CLINICAL GENE THERAPY FOR CHRONIC GRANULOMATOUS DISEASE: OPTIMIZATION OF GENE TRANSDUCTION INTO HEMATOPOIETIC STEM/ PROGENITOR CELLS

Author: Horiuchi, Yasuomi, Otsu, Makoto, Kiyokawa, Nobutaka, Migita, Osuke, Ogata, Tsutomu, Li, Xiao-Kang, Onodera, Masafumi, Kume, Akihiro, Okuyama, Torayuki, Fujimoto, Junichiro, Nakauchi, Hiromitsu, and Kuratsuji, Tadatoshi
Published: 2008
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66. Additional file 1: of Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet’s disease

Author: Tsuchida, Naomi, Kirino, Yohei, Yutaro Soejima, Onodera, Masafumi, Arai, Katsuhiro, Tamura, Eiichiro, Ishikawa, Takashi, Toshinao Kawai, Uchiyama, Toru, Nomura, Shigeru, Kobayashi, Daisuke, Taguri, Masataka, Mitsuhashi, Satomi, Mizuguchi, Takeshi, Takata, Atsushi, Miyake, Noriko, Nakajima, Hideaki, Miyatake, Satoko, and Naomichi Matsumoto
Abstract: Table S1. Clinical features of Japanese haploinsufficiency of A20 (HA20) and Japanese Behçet’s disease (BD). (DOCX 22 kb)
Published: 2019
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67. Additional file 2: of Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet’s disease

Author: Tsuchida, Naomi, Kirino, Yohei, Yutaro Soejima, Onodera, Masafumi, Arai, Katsuhiro, Tamura, Eiichiro, Ishikawa, Takashi, Toshinao Kawai, Uchiyama, Toru, Nomura, Shigeru, Kobayashi, Daisuke, Taguri, Masataka, Mitsuhashi, Satomi, Mizuguchi, Takeshi, Takata, Atsushi, Miyake, Noriko, Nakajima, Hideaki, Miyatake, Satoko, and Naomichi Matsumoto
Abstract: Table S2. Clinical features of haploinsufficiency of A20 (HA20) and the Pediatric Behçet’s disease (PEDBD). (DOCX 21 kb)
Published: 2019
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68. Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus

Author: Seki, Tatsunori, Namba, Takashi, Mochizuki, Hideki, and Onodera, Masafumi
Published: 2007
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69. An RNA-binding protein αCP-1 is involved in the STAT3-mediated suppression of NF-κB transcriptional activity

Author: Nishinakamura, Hitomi, Minoda, Yasumasa, Saeki, Kazuko, Koga, Keiko, Takaesu, Giichi, Onodera, Masafumi, Yoshimura, Akihiko, and Kobayashi, Takashi
Published: 2007

70. Antitumor activity of chimeric immunoreceptor gene-modified Tc1 and Th1 cells against autologous carcinoembryonic antigen-expressing colon cancer cells

Author: Sasaki, Takeshi, Ikeda, Hiroaki, Sato, Masayoshi, Ohkuri, Takayuki, Abe, Hiroyuki, Kuroki, Masahide, Onodera, Masafumi, Miyamoto, Masaki, Kondo, Satoshi, and Nishimura, Takashi
Published: 2006

71. The fate of neural progenitor cells expressing astrocytic and radial glial markers in the postnatal rat dentate gyrus

Author: Namba, Takashi, Mochizuki, Hideki, Onodera, Masafumi, Mizuno, Yoshikuni, Namiki, Hideo, and Seki, Tatsunori
Published: 2005

72. 糖鎖プライマー法を基盤とするムコ多糖症診断プローブの創製

Author: 慶應義塾大学・理工学部 (矢上)・教授, 国立成育医療研究センター成育遺伝研究部・部長, 国立成育医療研究センターマススクリーニング研究室・研究員, サトウ, トシノリ, オノデラ, マサフミ, ナカジマ, ヒデキ, Satō, Toshinori, Onodera, Masafumi, Nakajima, Hideki, 佐藤, 智典, 小野寺, 雅史, 中島, 英規, 慶應義塾大学・理工学部 (矢上)・教授, 国立成育医療研究センター成育遺伝研究部・部長, 国立成育医療研究センターマススクリーニング研究室・研究員, サトウ, トシノリ, オノデラ, マサフミ, ナカジマ, ヒデキ, Satō, Toshinori, Onodera, Masafumi, Nakajima, Hideki, 佐藤, 智典, 小野寺, 雅史, and 中島, 英規
Abstract: Research team head, Research team member, publisher, ムコ多糖症 (MPS) は先天性のライソゾーム病のひとつである。本課題では、MPSの早期診断を実現するために、新生児マススクリーニングで利用可能な診断プローブとなる糖鎖ライブラリーを作製した。糖鎖ライブラリーの作製には、糖鎖生合成経路の前駆体である糖鎖プライマーXyl-Ser-C12を用いた。糖鎖プライマーを、正常ヒト皮膚繊維芽細胞等の細胞培養液中に添加し、得られた糖鎖ライブラリーの構造をLC-MSにより解析した。得られた糖鎖ライブラリー中からMPS診断基質化合物を探索するために、糖分解酵素を用いて糖鎖の配列解析を行った。結果として、MPSⅠ型とII型の診断基質候補となる糖鎖が得られた。 Mucopolysaccharidosis (MPS) is one of the congenital lysosomal diseases. In this study, in order to realize early diagnosis of MPS, we have prepared a saccharide library to be a diagnostic probe that can be used in newborn screening. For preparation of a saccharide library, saccharide primer Xyl-Ser-C12, which is a precursor of a glycan biosynthesis pathway, was used. The saccharide primer was added to the cell culture medium of normal human skin fibroblasts, and the structure of the obtained saccharide library was analyzed by LC-MS. In order to search MPS diagnostic substrate compounds from the obtained saccharide library, sequence analysis was performed using glycolytic enzymes. As a result, sugar chains that can be used as diagnostic substrates for MPS type I and type II were obtained., 研究種目 : 挑戦的研究(萌芽) 研究期間 : 2017～2018 課題番号 : 17K19208 研究分野 : 生体分子工学
Published: 2019

73. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

Author: Yagi, Haruhiko, Nomura, Takashi, Nakamura, Kyoko, Yamazaki, Sayuri, Kitawaki, Toshio, Hori, Shohei, Maeda, Michiyuki, Onodera, Masafumi, Uchiyama, Takashi, Fujii, Shingo, and Sakaguchi, Shimon
Published: 2004

74. A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.

Author: Kataura, Tetsushi, Tashiro, Etsu, Nishikawa, Shota, Shibahara, Kensuke, Muraoka, Yoshihito, Miura, Masahiro, Sakai, Shun, Katoh, Naohiro, Totsuka, Misato, Onodera, Masafumi, Shin-Ya, Kazuo, Miyamoto, Kengo, Sasazawa, Yukiko, Hattori, Nobutaka, Saiki, Shinji, and Imoto, Masaya
Subjects: AUTOPHAGY, CHEMOGENOMICS, NEURODEGENERATION, ENDOPLASMIC reticulum, SMALL molecules
Abstract: Macroautophagy/autophagy plays a critical role in the pathogenesis of various human diseases including neurodegenerative disorders such as Parkinson disease (PD) and Huntington disease (HD). Chemical autophagy inducers are expected to serve as disease-modifying agents by eliminating cytotoxic/damaged proteins. Although many autophagy inducers have been identified, their precise molecular mechanisms are not fully understood because of the complicated crosstalk among signaling pathways. To address this issue, we performed several chemical genomic analyses enabling us to comprehend the dominancy among the autophagy-associated pathways followed by an aggresome-clearance assay. In a first step, more than 400 target-established small molecules were assessed for their ability to activate autophagic flux in neuronal PC12D cells, and we identified 39 compounds as autophagy inducers. We then profiled the autophagy inducers by testing their effect on the induction of autophagy by 200 well-established signal transduction modulators. Our principal component analysis (PCA) and clustering analysis using a dataset of "autophagy profiles" revealed that two Food and Drug Administration (FDA)-approved drugs, memantine and clemastine, activate endoplasmic reticulum (ER) stress responses, which could lead to autophagy induction. We also confirmed that SMK-17, a recently identified autophagy inducer, induced autophagy via the PRKC/PKC-TFEB pathway, as had been predicted from PCA. Finally, we showed that almost all of the autophagy inducers tested in this present work significantly enhanced the clearance of the protein aggregates observed in cellular models of PD and HD. These results, with the combined approach, suggested that autophagy-activating small molecules may improve proteinopathies by eliminating nonfunctional protein aggregates. Abbreviations: ADK: adenosine kinase; AMPK: AMP-activated protein kinase; ATF4: activating transcription factor 4; BECN1: beclin-1; DDIT3/CHOP: DNA damage inducible transcript 3; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; EIF2S1/eIF2α: eukaryotic translation initiation factor 2 subunit alpha; ER: endoplasmic reticulum; ERN1/IRE1α: endoplasmic reticulum to nucleus signaling 1; FDA: Food and Drug Administration; GSH: glutathione; HD: Huntington disease; HSPA5/GRP78: heat shock protein family A (Hsp70) member 5; HTT: huntingtin; JAK: Janus kinase, MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MAP2K/MEK: mitogen-activated protein kinase kinase; MAP3K8/Tpl2: mitogen-activated protein kinase kinase kinase 8; MAPK: mitogen-activated protein kinase; MPP+: 1-methyl-4-phenylpyridinium; MTOR: mechanistic target of rapamycin kinase; MTORC: MTOR complex; NAC: N-acetylcysteine; NGF: nerve growth factor 2; NMDA: N-methyl-D-aspartate; PCA: principal component analysis; PD: Parkinson disease; PDA: pancreatic ductal adenocarcinoma; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PMA: phorbol 12-myristate 13-acetate; PRKC/PKC: protein kinase C; ROCK: Rho-associated coiled-coil protein kinase; RR: ribonucleotide reductase; SIGMAR1: sigma non-opioid intracellular receptor 1; SQSTM1/p62: sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TFEB: Transcription factor EB; TGFB/TGF-β: Transforming growth factor beta; ULK1: unc-51 like autophagy activating kinase 1; XBP1: X-box binding protein 1. [ABSTRACT FROM AUTHOR]
Published: 2021
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75. Neurogenesis After Transient Global Ischemia in the Adult Hippocampus Visualized by Improved Retroviral Vector

Author: Tanaka, Ryota, Yamashiro, Kazuo, Mochizuki, Hideki, Cho, Nei, Onodera, Masafumi, Mizuno, Yoshikuni, and Urabe, Takao
Published: 2004
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76. Prospective identification and enrichment of self-renewing multipotential hepatic stem cells by flow cytometric cell sorting

Author: Suzuki, Atsushi, Zheng, Yun-wen, Kaneko, Shin, Onodera, Masafumi, Fukao, Katashi, Nakauchi, Hiromitsu, and Taniguchi, Hideki
Published: 2001

77. Retroviral-Mediated Transfer andExpression of the Common Gamma Chain intoHuman Hematopoietic Progenitors

Author: Candotti, Fabio, Onodera, Masafumi, Knazek, Richard A., and Blaese, Michael R.
Published: 1999
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78. Gene Therapy for Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency: Improved Retroviral Vectors for Clinical Trials

Author: Onodera, Masafumi, Nelson, David M., Sakiyama, Yukio, Candotti, Fabio, and Blaese, Michael R.
Published: 1999
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79. Infectivity Assessment of Recombinant Adeno-Associated Virus and Wild-Type Adeno-Associated Virus Exposed to Various Diluents and Environmental Conditions

Author: Tomono, Taro, primary, Hirai, Yukihiko, additional, Chono, Hideto, additional, Mineno, Junichi, additional, Ishii, Akiko, additional, Onodera, Masafumi, additional, Tamaoka, Akira, additional, and Okada, Takashi, additional
Published: 2019
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80. Establishment of immunity against Epstein‐Barr virus infection in a patient with CHARGE/complete DiGeorge syndrome after peripheral blood lymphocyte transfusion

Author: Hosaka, Sho, primary, Kobayashi, Chie, additional, Saito, Hirota, additional, Imai-Saito, Ayako, additional, Suzuki, Ryoko, additional, Iwabuchi, Atsushi, additional, Kato, Yoshiaki, additional, Jimbo, Takahiro, additional, Watanabe, Nobuyuki, additional, Onodera, Masafumi, additional, Imadome, Ken‐Ichi, additional, Masumoto, Kouji, additional, Nanmoku, Toru, additional, Fukushima, Takashi, additional, Kosaki, Kenjiro, additional, Sumazaki, Ryo, additional, and Takada, Hidetoshi, additional
Published: 2019
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81. Thymitis in chronic granulomatous disease

Author: Kanamori, Keita, primary, Tamura, Eiichiro, additional, Onodera, Masafumi, additional, Ishiguro, Akira, additional, and Kawai, Toshinao, additional
Published: 2019
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82. Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy

Author: Kimura, Yasuyoshi, primary, Shofuda, Tomoko, additional, Higuchi, Yuichiro, additional, Nagamori, Ippei, additional, Oda, Masaaki, additional, Nakamori, Masayuki, additional, Onodera, Masafumi, additional, Kanematsu, Daisuke, additional, Yamamoto, Atsuyo, additional, Katsuma, Asako, additional, Suemizu, Hiroshi, additional, Nakano, Toru, additional, Kanemura, Yonehiro, additional, and Mochizuki, Hideki, additional
Published: 2019
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83. Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9

Author: Tomono, Taro, primary, Hirai, Yukihiko, additional, Okada, Hironori, additional, Miyagawa, Yoshitaka, additional, Adachi, Kumi, additional, Sakamoto, Shuhei, additional, Kawano, Yasuhiro, additional, Chono, Hideto, additional, Mineno, Junichi, additional, Ishii, Akiko, additional, Shimada, Takashi, additional, Onodera, Masafumi, additional, Tamaoka, Akira, additional, and Okada, Takashi, additional
Published: 2018
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84. Attempt to Prove the Existence of Abnormal B Lymphocyte As Myeloma-Initiating Cells from B Cell-Derived Induced Pluripotent Stem Cells

Author: Yanagi, Aki, primary, Tsuyama, Naohiro, additional, Yanai, Yukari, additional, Abe, Yu, additional, Sugai, Misaki, additional, Ota, Akinobu, additional, Sivasundaram, Karnan, additional, Shigemura, Tomonari, additional, Sasatani, Megumi, additional, Kamiya, Kenji, additional, Hanamura, Ichiro, additional, Ikezoe, Takayuki, additional, Onodera, Masafumi, additional, and Sakai, Akira, additional
Published: 2018
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85. Multiple osteolytic lesions on the skull of a girl with Mendelian susceptibility to mycobacterial disease

Author: Shoji, Kensuke, primary, Kawai, Toshinao, additional, Onodera, Masafumi, additional, Tsutsumi, Yoshiyuki, additional, Nosaka, Shunsuke, additional, and Miyairi, Isao, additional
Published: 2018
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86. Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis

Author: Osawa, Mitsujiro, Yamaguchi, Tomoyuki, Nakamura, Yukio, Kaneko, Shin, Onodera, Masafumi, Sawada, Ken-ichi, Jegalian, Armin, Wu, Hong, Nakauchi, Hiromitsu, and Iwama, Atsushi
Published: 2002
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87. A prospective study of allogeneic transplantation from unrelated donors for chronic granulomatous disease with target busulfan-based reduced-intensity conditioning

Author: Osumi, Tomoo, primary, Tomizawa, Daisuke, additional, Kawai, Toshinao, additional, Sako, Mayumi, additional, Inoue, Eisuke, additional, Takimoto, Tetsuya, additional, Tamura, Eiichiro, additional, Uchiyama, Toru, additional, Imadome, Ken-Ichi, additional, Taniguchi, Maki, additional, Shirai, Ryota, additional, Yoshida, Masanori, additional, Ando, Rie, additional, Tsumura, Yusuke, additional, Fuji, Hiroshi, additional, Matsumoto, Kana, additional, Shioda, Yoko, additional, Kiyotani, Chikako, additional, Terashima, Keita, additional, Onodera, Masafumi, additional, Matsumoto, Kimikazu, additional, and Kato, Motohiro, additional
Published: 2018
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88. Development of gene therapy using genome editing technology

Author: Onodera, Masafumi, primary
Published: 2018
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89. Effects of enzyme replacement therapy on immune function in ADA deficiency patient

Author: Nakazawa, Yumiko, Kawai, Toshinao, Uchiyama, Toru, Goto, Fumihiro, Watanabe, Nobuyuki, Maekawa, Takanobu, Ishiguro, Akira, Okuyama, Torayuki, Otsu, Makoto, Yamada, Masafumi, Hershfield, Michael S., Ariga, Tadashi, and Onodera, Masafumi
Published: 2015
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90. Single Cell-Based Vector Tracing in Patients with ADA-SCID Treated with Stem Cell Gene Therapy

Author: Igarashi, Yuka, primary, Uchiyama, Toru, additional, Minegishi, Tomoko, additional, Takahashi, Sirirat, additional, Watanabe, Nobuyuki, additional, Kawai, Toshinao, additional, Yamada, Masafumi, additional, Ariga, Tadashi, additional, and Onodera, Masafumi, additional
Published: 2017
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91. Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells

Author: Kawamura, Fumihiko, primary, Inaki, Makoto, additional, Katafuchi, Atsushi, additional, Abe, Yu, additional, Tsuyama, Naohiro, additional, Kurosu, Yumiko, additional, Yanagi, Aki, additional, Higuchi, Mitsunori, additional, Muto, Satoshi, additional, Yamaura, Takumi, additional, Suzuki, Hiroyuki, additional, Noji, Hideyoshi, additional, Suzuki, Shinichi, additional, Yoshida, Mitsuaki A., additional, Sasatani, Megumi, additional, Kamiya, Kenji, additional, Onodera, Masafumi, additional, and Sakai, Akira, additional
Published: 2017
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92. Reduced intensity stem cell transplantation with targeted BU from unrelated donor for chronic granulomatous disease

Author: Shirai, Ryota, primary, Osumi, Tomoo, additional, Yamada, Yuji, additional, Goto, Fumihiro, additional, Nakazawa, Yumiko, additional, Shioda, Yoko, additional, Kiyotani, Chikako, additional, Terashima, Keita, additional, Imadome, Ken-Ichi, additional, Matsumoto, Kana, additional, Morita, Kunihiko, additional, Uchiyama, Toru, additional, Kawai, Toshinao, additional, Onodera, Masafumi, additional, Tomizawa, Daisuke, additional, Kato, Motohiro, additional, and Matsumoto, Kimikazu, additional
Published: 2017
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93. Establishment of Induced Pluripotent Stem Cells from Lymph Node B Cells and Induction of Aid Expression in Their Differentiation into Hematopoietic Stem Cells

Author: Kawamura, Fumihiko, primary, Makoto, Inaki, additional, Katafuchi, Atsushi, additional, Abe, Yu, additional, Tsuyama, Naohiro, additional, Kurosu, Yumiko, additional, Yanagi, Aki, additional, Higuchi, Mitsunori, additional, Muto, Satoshi, additional, Yamamura, Takumi, additional, Suzuki, Hiroyuki, additional, Noji, Hideyoshi, additional, Suzuki, Shinichi, additional, Yoshida, Mitsuaki A, additional, Sasatani, Megumi, additional, Kamiya, Kenji, additional, Onodera, Masafumi, additional, and Sakai, Akira, additional
Published: 2016
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94. Nucleotide substitutions in CD101 , the human homolog of a diabetes susceptibility gene in non-obese diabetic mouse, in patients with type 1 diabetes

Author: Okuno, Misako, primary, Kasahara, Yoshihito, additional, Onodera, Masafumi, additional, Takubo, Noriyuki, additional, Okajima, Michiko, additional, Suga, Shigeru, additional, Watanabe, Nobuyuki, additional, Suzuki, Junichi, additional, Ayabe, Tadayuki, additional, Urakami, Tatsuhiko, additional, Kawamura, Tomoyuki, additional, Kikuchi, Nobuyuki, additional, Yokota, Ichiro, additional, Kikuchi, Toru, additional, Amemiya, Shin, additional, Nakabayashi, Kazuhiko, additional, Hayashi, Keiko, additional, Hata, Kenichiro, additional, Matsubara, Yoichi, additional, Ogata, Tsutomu, additional, Fukami, Maki, additional, and Sugihara, Shigetaka, additional
Published: 2016
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95. Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3is clinically distinct from Behçet’s disease

Author: Tsuchida, Naomi, Kirino, Yohei, Soejima, Yutaro, Onodera, Masafumi, Arai, Katsuhiro, Tamura, Eiichiro, Ishikawa, Takashi, Kawai, Toshinao, Uchiyama, Toru, Nomura, Shigeru, Kobayashi, Daisuke, Taguri, Masataka, Mitsuhashi, Satomi, Mizuguchi, Takeshi, Takata, Atsushi, Miyake, Noriko, Nakajima, Hideaki, Miyatake, Satoko, and Matsumoto, Naomichi
Abstract: Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3variants. Phenotypic and genetic features of HA20 remain uncertain; therefore, the clinical distinction between HA20 and Behçet’s disease (BD) requires clarification. We have collected 12 Japanese BD-like families. Probands of these families were analyzed by whole exome sequencing (WES) and subsequent Sanger sequencing. Clinical features were compared between 54 HA20 patients (including previously reported and new cases) and 520 Japanese BD patients. We identified c.1434C>A:p.(Cys478*) in one family and a 236 kb deletion at 6q23.3 containing TNFAIP3in another family. Four HA20 patients in the two families presented with childhood-onset recurrent oral and genital ulcers and were initially diagnosed and treated as BD. Consistent with the clinical features of HA20, recurrent, refractory fever attacks (three of four patients), and digestive ulcers (two of the four patients) were observed. A comparison of clinical features between HA20 patients and cohorts of BD patients revealed several critical features specific to HA20. These were early-onset, familial occurrence, recurrent fever attacks, gastrointestinal involvement, and infrequent ocular involvement. We identified a novel nonsense variant and deletion of the entire TNFAIP3gene in two unrelated Japanese HA20 families. Genetic screening of TNFAIP3should be considered for familial BD-like patients with early-onset recurrent fevers.
Published: 2019
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96. 308. Ultracentrifugation-Free Chromatography-Mediated Large-Scale Purification of Recombinant Adeno-Associated Virus Serotype 1 (rAAV1) and rAAV9 from the Serum-Free Culture Supernatant

Author: Tomono, Taro, primary, Hirai, Yukihiko, additional, Okada, Hironori, additional, Adachi, Kumi, additional, Ishii, Akiko, additional, Shimada, Takashi, additional, Onodera, Masafumi, additional, Tamaoka, Akira, additional, and Okada, Takashi, additional
Published: 2016
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97. 224. A Gene Therapy Clinical Study of a Patient with X-Linked Chronic Granulomatous Disease

Author: Kawai, Toshinao, primary, Okamura, Kohji, additional, Yagita, Mari, additional, Goto, Fumihiro, additional, Nakazawa, Yumiko, additional, Uchiyama, Toru, additional, Nakabayashi, Kazuhiko, additional, Nunoi, Hiroyuki, additional, Malech, Harry, additional, and Onodera, Masafumi, additional
Published: 2016
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98. Effect of the linkers between the zinc fingers in zinc finger protein 809 on gene silencing and nuclear localization

Author: Ichida, Yu, primary, Utsunomiya, Yuko, additional, and Onodera, Masafumi, additional
Published: 2016
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99. Long time-course monitoring of ZFP809-mediated gene silencing in transgene expression driven by promoters containing MLV-derived PBS

Author: Ichida, Yu, primary, Utsunomiya, Yuko, additional, Tomikawa, Junko, additional, Nakabayashi, Kazuhiko, additional, Sato, Toshinori, additional, and Onodera, Masafumi, additional
Published: 2016
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100. Leopard Skin–Like Colonic Mucosa

Author: Obayashi, Naho, primary, Arai, Katsuhiro, additional, Nakano, Natsuko, additional, Mizukami, Tomoyuki, additional, Kawai, Toshinao, additional, Yamamoto, Shojiro, additional, Shimizu, Hirotaka, additional, Nunoi, Hiroyuki, additional, Shimizu, Toshiaki, additional, Tang, Julian, additional, and Onodera, Masafumi, additional
Published: 2016
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