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55. Postnatal Treatment in Fetal and Neonatal Alloimmune Thrombocytopenia: An International Cohort Study

Author

de Vos, Thijs, primary, Winkelhorst, Dian, additional, Árnadóttir, Valgerdur, additional, van der Bom, Johanna G., additional, Suris, Carme Canals, additional, Caram-Deelder, Camila, additional, Deschmann, Emöke, additional, Haysom, Helen E., additional, Hverven, Hem Birgit C., additional, Krivec, Jana Lozar, additional, McQuilten, Zoe, additional, Diaz, Eduardo Muñiz, additional, Nogués, Núria, additional, Oepkes, Dick, additional, Porcelijn, Leendert, additional, van der Schoot, C. Ellen, additional, Saxonhouse, Matthew, additional, Sola-Visner, Martha, additional, Tiblad, Eleonor, additional, Tiller, Heidi, additional, Wood, Erica M., additional, Young, Vanessa, additional, Železnik, Mojca, additional, de Haas, Masja, additional, and Lopriore, Enrico, additional

Published
2022
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58. List of Contributors

Author

Agathokleous, Maria, primary, Allan, Lindsey D, additional, Bower, Sarah, additional, Cannie, Mieke, additional, Chaoui, Rabih, additional, Chaveeva, Petya, additional, Coady, Anne Marie, additional, De Catte, Luc, additional, Deprest, Jan, additional, Devlieger, Roland, additional, Dhillon, H K, additional, Farndon, Peter A, additional, Jani, Jacques, additional, Jeanty, Phillippe, additional, Homfray, Tessa, additional, Karl, Katrin, additional, Khalil, Asma, additional, Kilby, Mark, additional, Kyle, Philipa, additional, Leruez, Marianne, additional, Lewi, Liesbeth, additional, Napolitano, Raffaele, additional, Nicolaides, Kypros H, additional, Oepkes, Dick, additional, Paladini, Dario, additional, Pandya, Pranav P, additional, Papageorghiou, Aris T, additional, Pereira, Susana, additional, Pryce, Jeremy W, additional, Russell, Sarah A, additional, Sankaran, Srividhya, additional, Savvidou, Makrina, additional, Sebire, Neil J, additional, Selman, Tara, additional, Suff, Natalie, additional, To, Meekai, additional, Tsikhanenka, Irina, additional, Ville, Yves, additional, Weston, Michael J, additional, Yu, Christina K H, additional, and Zidere, Vita, additional

Published
2015
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60. The effectiveness of multifetal pregnancy reduction in trichorionic triplet gestation

Author

van de Mheen, Lidewij, Everwijn, Sheila M.P., Knapen, Maarten F.C.M., Oepkes, Dick, Engels, Melanie, Manten, Gwendolyn T.R., Zondervan, Hans, Wirjosoekarto, Soetinah A.M., van Vugt, John M.G., Erwich, Jan Jaap H.M., Nij Bijvank, Sebastiaan W.A., Ravelli, Anita, Heemelaar, Steffie, van Pampus, Maria G., de Groot, Christianne J.M., Mol, Ben W.J., and Pajkrt, Eva

Published
2014
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63. Association between low fetal fraction in cell-free DNA testing and adverse pregnancy outcome: A systematic review:A systematic review

Author

Scheffer, Peter G., Wirjosoekarto, Soetinah A. M., Becking, Ellis C., Weiss, Marjan M., Bax, Caroline J., Oepkes, Dick, Sistermans, Erik A., Henneman, Lidewij, and Bekker, Mireille N.

Abstract

Objective: Low fetal fraction (LFF) in prenatal cell-free DNA (cfDNA) testing is an important cause of test failure and no-call results. LFF might reflect early abnormal placentation and therefore be associated with adverse pregnancy outcome. Here, we review the available literature on the relationship between LFF in cfDNA testing and adverse pregnancy outcome. Method: A systematic literature search was conducted in MEDLINE and EMBASE up to November 1, 2020. Results: Five studies met the criteria for inclusion; all were retrospective observational cohort studies. The cohort sizes ranged from 370 to 6375 pregnancies, with all tests performed in the first trimester or early second trimester. A 4% cutoff for LFF was used in two studies, two studies used the 5th and 25th percentiles, respectively, and one study used a variety of cutoff values for LFF. LFF in prenatal cfDNA testing was observed to be associated with hypertensive disease of pregnancy, small for gestational age neonates, and preterm birth. Conflicting results were found regarding the association between LFF and gestational diabetes mellitus. Conclusions: LFF in cfDNA testing is associated with adverse pregnancy outcome,specifically pregnancy-related hypertensive disorders, preterm birth, and impaired fetal growth related to placental dysfunction. Since the available evidence is limited, a large prospective cohort study on the relationship between fetal fraction and pregnancy outcomes is needed.

Published
2021
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70. Clinical characteristics of human platelet antigen (HPA)‐1a and HPA‐5b alloimmunised pregnancies and the association between platelet HPA‐5b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia

Author

de Vos, Thijs W., primary, Porcelijn, Leendert, additional, Hofstede‐van Egmond, Suzanne, additional, Pajkrt, Eva, additional, Oepkes, Dick, additional, Lopriore, Enrico, additional, van der Schoot, C. Ellen, additional, Winkelhorst, Dian, additional, and de Haas, Masja, additional

Published
2021
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74. Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study

Author

Vos, Thijs W. de, Winkelhorst, Dian, Baelde, Hans J., Dijkstra, Kyra L., Bergen, Rianne D. M. van, Meeren, Lotte E. van der, Nikkels, Peter G. J., Porcelijn, Leendert, Schoot, C. Ellen van der, Vidarsson, Gestur, Eikmans, Michael, Kapur, Rick, Keur, Carin van der, Trouw, Leendert A., Oepkes, Dick, Lopriore, Enrico, Hoorn, Marie-Louise P. van der, Bos, Manon, Haas, Masja de, Vos, Thijs W. de, Winkelhorst, Dian, Baelde, Hans J., Dijkstra, Kyra L., Bergen, Rianne D. M. van, Meeren, Lotte E. van der, Nikkels, Peter G. J., Porcelijn, Leendert, Schoot, C. Ellen van der, Vidarsson, Gestur, Eikmans, Michael, Kapur, Rick, Keur, Carin van der, Trouw, Leendert A., Oepkes, Dick, Lopriore, Enrico, Hoorn, Marie-Louise P. van der, Bos, Manon, and Haas, Masja de

Published
2021

75. Factors associated with poor outcome in fetuses prenatally diagnosed with sacrococcygeal teratoma

Author

van Heurn, Lieke J., Coumans, Audrey B.C., Derikx, Joep P.M., Bekker, Mireille N., Bilardo, Katia M., Duin, Leonie K., Knapen, Maarten F.C.M., Pajkrt, Eva, Sikkel, Esther, van Heurn, L. W.Ernest, Oepkes, Dick, van Heurn, Lieke J., Coumans, Audrey B.C., Derikx, Joep P.M., Bekker, Mireille N., Bilardo, Katia M., Duin, Leonie K., Knapen, Maarten F.C.M., Pajkrt, Eva, Sikkel, Esther, van Heurn, L. W.Ernest, and Oepkes, Dick

Abstract

Aim of the study: Outcome of fetuses, prenatally diagnosed with sacrococcygeal teratoma (SCT), is still poorly documented. This study assesses the incidence and prenatal predictors of outcome in all fetuses prenatally diagnosed with SCT. Methods: This is a retrospective study on all fetuses prenatally diagnosed with SCT from 1998 to 2018 in the Netherlands. Poor outcome was defined as terminations of pregnancy (TOP) because of expected unfavorable outcome, intrauterine fetal death, or early neonatal death. Potential risk factors for poor outcome were analyzed. Main results: Eighty-four fetuses were included. Sixteen (19.0%) TOPs were excluded from statistical analysis. Eleven of the remaining 68 fetuses had poor outcome. Overall mortality was 32.1%, with a mortality excluding TOPs of 13.1%. Thirteen fetal interventions were performed in 11 (13.1%) fetuses. Potential risk factors for poor outcome were the presence of fetal hydrops (OR: 21.0, CI: 2.6–275.1, p = 0.012) and cardiomegaly (OR: 10.3, CI: 1.9–55.8, p = 0.011). Conclusions: The overall mortality of fetuses prenatally diagnosed with SCTs including tTOP was 32.1%. This high mortality rate was mainly due to termination of pregnancy. Mortality excluding TOP was 13.1%. Potential risk factors for poor outcome were fetal hydrops and cardiomegaly.

Published
2021

76. Association between low fetal fraction in cell-free DNA testing and adverse pregnancy outcome: A systematic review

Author

MS Verloskunde, Child Health, Circulatory Health, Scheffer, Peter G., Wirjosoekarto, Soetinah A.M., Becking, Ellis C., Weiss, Marjan M., Bax, Caroline J., Oepkes, Dick, Sistermans, Erik A., Henneman, Lidewij, Bekker, Mireille N., MS Verloskunde, Child Health, Circulatory Health, Scheffer, Peter G., Wirjosoekarto, Soetinah A.M., Becking, Ellis C., Weiss, Marjan M., Bax, Caroline J., Oepkes, Dick, Sistermans, Erik A., Henneman, Lidewij, and Bekker, Mireille N.

Published
2021

77. Factors associated with poor outcome in fetuses prenatally diagnosed with sacrococcygeal teratoma

Author

MS Verloskunde, Child Health, Circulatory Health, van Heurn, Lieke J., Coumans, Audrey B.C., Derikx, Joep P.M., Bekker, Mireille N., Bilardo, Katia M., Duin, Leonie K., Knapen, Maarten F.C.M., Pajkrt, Eva, Sikkel, Esther, van Heurn, L. W.Ernest, Oepkes, Dick, MS Verloskunde, Child Health, Circulatory Health, van Heurn, Lieke J., Coumans, Audrey B.C., Derikx, Joep P.M., Bekker, Mireille N., Bilardo, Katia M., Duin, Leonie K., Knapen, Maarten F.C.M., Pajkrt, Eva, Sikkel, Esther, van Heurn, L. W.Ernest, and Oepkes, Dick

Published
2021

78. Placental complement activation in fetal and neonatal alloimmune thrombocytopenia: An observational study

Author

Pathologie Pathologen staf, Cancer, de Vos, Thijs W., Winkelhorst, Dian, Baelde, Hans J., Dijkstra, Kyra L., van Bergen, Rianne D.M., van der Meeren, Lotte E., Nikkels, Peter G.J., Porcelijn, Leendert, van der Schoot, C. Ellen, Vidarsson, Gestur, Eikmans, Michael, Kapur, Rick, van der Keur, Carin, Trouw, Leendert A., Oepkes, Dick, Lopriore, Enrico, van der Hoorn, Marie Louise P., Bos, Manon, de Haas, Masja, Pathologie Pathologen staf, Cancer, de Vos, Thijs W., Winkelhorst, Dian, Baelde, Hans J., Dijkstra, Kyra L., van Bergen, Rianne D.M., van der Meeren, Lotte E., Nikkels, Peter G.J., Porcelijn, Leendert, van der Schoot, C. Ellen, Vidarsson, Gestur, Eikmans, Michael, Kapur, Rick, van der Keur, Carin, Trouw, Leendert A., Oepkes, Dick, Lopriore, Enrico, van der Hoorn, Marie Louise P., Bos, Manon, and de Haas, Masja

Published
2021

79. Non-Invasive Chromosomal Evaluation (NICE) Study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18

Author

Norton, Mary E., Brar, Herb, Weiss, Jonathan, Karimi, Ardeshir, Laurent, Louise C., Caughey, Aaron B., Rodriguez, Hellen M., Williams, John, III, Mitchell, Michael E., Adair, Charles D., Lee, Hanmin, Jacobsson, Bo, Tomlinson, Mark W., Oepkes, Dick, Hollemon, Desiree, Sparks, Andrew B., Oliphant, Arnold, and Song, Ken

Published
2012
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91. Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study

Author

de Vos, Thijs W., primary, Winkelhorst, Dian, additional, Baelde, Hans J., additional, Dijkstra, Kyra L., additional, van Bergen, Rianne D. M., additional, van der Meeren, Lotte E., additional, Nikkels, Peter G. J., additional, Porcelijn, Leendert, additional, van der Schoot, C. Ellen, additional, Vidarsson, Gestur, additional, Eikmans, Michael, additional, Kapur, Rick, additional, van der Keur, Carin, additional, Trouw, Leendert A., additional, Oepkes, Dick, additional, Lopriore, Enrico, additional, van der Hoorn, Marie-Louise P., additional, Bos, Manon, additional, and de Haas, Masja, additional

Published
2021
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94. Fetoscopic myelomeningocoele closure: Is the scientific evidence enough to challenge the gold standard for prenatal surgery?

Author

Verweij, E. Joanne, primary, Vries, Martine C., additional, Oldekamp, Esther J., additional, Eggink, Alex J., additional, Oepkes, Dick, additional, Slaghekke, Femke, additional, Spoor, Jochem K. H., additional, Deprest, Jan A., additional, Miller, Jena L., additional, Baschat, Ahmet A., additional, and DeKoninck, Philip L. J., additional

Published
2021
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98. The Ethics of Consent for Fetal Therapy

Author

van der Hout, Sanne, Dondorp, Wybo, de Wert, Guido, Kilby, Mark D., Johnson, Anthony, Oepkes, Dick, RS: GROW - R4 - Reproductive and Perinatal Medicine, RS: CAPHRI - R6 - Promoting Health & Personalised Care, and Metamedica

Subjects
medicine.medical_specialty, business.industry, Obstetrics, Medicine, business, Fetal therapy
Abstract

In this chapter, we will discuss the ethics of consent for fetal therapy. The latter term refers to a very broad field, ranging from open surgery to pharmacotherapy, from experimental procedures to accepted treatment, and from interventions aimed at saving fetuses from in utero or perinatal death to treatments with a rationale of improving long-term health outcomes. Because the fetus can only be treated via the body of the pregnant woman, fetal therapy is always a form of ‘maternal-fetal medicine’ and cannot be performed without her informed consent (or that of her representative). However, what makes informed consent for fetal therapy special is that, unlike in other medical contexts, the consenting (or non-consenting) person not only decides for herself, but also for the fetus who may or may not survive and/or for the future child who may or may not benefit. As a consequence, consent for fetal therapy is inevitably asked and given in the context of ideas about the responsibility of the pregnant woman as an expectant mother, a responsibility that, rightly or wrongly, is either assumed by her from within or ascribed to her from without.

Published
2020
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99. The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

Author

Buffin-Meyer, Bénédicte, Klein, Julie, van der Zanden, Loes F M, Levtchenko, Elena, Moulos, Panogiotis, Lounis, Nadia, Conte-Auriol, Françoise, Hindryckx, An, Wühl, Elke, Persico, Nicola, Oepkes, Dick, Schreuder, Michiel F, Tkaczyk, Marcin, Ariceta, Gema, Fossum, Magdalena, Parvex, Paloma, Feitz, Wout, Olsen, Henning, Montini, Giovanni, Decramer, Stéphane, Schanstra, Joost P, De Catte, Luc, Vayssieres, Christophe, Sartor, Agnès, Groussolles, Marion, Plard, Christelle, Guerby, Paul, Connan, Laure, Morin, Mathieu, Simon, Elizabeth, Breaud, Jean, Saliou, Anne-Hélène, De Parscau, Loic, Jay, Nadine, Germouty, Isabelle, Le Bouar, Gwenaelle, Ryckewaert, Amelie, Manca-Pellissier, Marie-Christine, Merrot, Thierry, Laurichesse, Helene, Gallot, Denis, Bessenay, Lucie, Bidat, Laurent, Boize, Philippe, Winer, Norbert, Allain-Launey, Emma, Le Vaillant, Claudine, Prieur, Fabienne, Lavocat, Marie-Pierre, Coatleven, Frederic, Debromez, Eric, Harembat, Jérôme, Llanas, Brigitte, Favre, Romain, Moog, Raphael, Zaloszyc, Ariane, Massardier, Jérôme, Demede, Delphine, Perrotin, Franck, Cloarec, Sylvie, Vequeau-Goua, Valérie, Descombes, Emmanuelle, Boulot, Pierre, Morin, Denis, Fuchs, Florent, Tenenbaum, Julie, Ville, Yves, Blanc, Thomas, Heidet, Laurence, Paris, Anne, Dobremez, Eric, Froute, Marie-Françoise, Gondry, Jean, Muszynski, Charles, Haraux, Elodie, Lobelle, Fabienne, Chevreau, Julien, Rosenblatt, Jonathan, Baudoin, Véronique, Deschenes, Georges, Guigue, Virginie, Amblard, Florence, Bourdat-Michel, Guylhène, Schaefer, Franz, Elsässer, Michael, Rossi, Federica, Manzoni, Gianantonio, De Marco, Erika A, Capone, Valentina, Caforio, Leonardo, Zaccara, Antonio, Innocenzi, Michele, Bagolan, Pietro, Capozza, Nicola, Castagnetti, Marco, Mancini, Mariangela, van Scheltema, Phebe Adama, Kortmann, Barbara, Schreuder, Michiel, Stańczyk, Małgorzata, Szaflik, Krzysztof, Wojtera, Justyna, Krzeszowski, Waldemar, Talar, Tomasz, Pawłowska, Barbara, Fortecka-Piestrzeniewicz, Katarzyna, Olejniczak, Dariusz, Arevalo, Silvia, Rodo, Carlota, Lindgren, Peter, Chehade, Hassib, ANTENATAL Consortium, Hindryckx, A., De Catte, L., Vayssieres, C., Sartor, A., Groussolles, M., Plard, C., Guerby, P., Connan, L., Morin, M., Simon, E., Breaud, J., Saliou, A.H., De Parscau, L., Jay, N., Germouty, I., Le Bouar, G., Ryckewaert, A., Manca-Pellissier, M.C., Merrot, T., Laurichesse, H., Gallot, D., Bessenay, L., Bidat, L., Boize, P., Winer, N., Allain-Launey, E., Le Vaillant, C., Prieur, F., Lavocat, M.P., Coatleven, F., Debromez, E., Harembat, J., Llanas, B., Favre, R., Moog, R., Zaloszyc, A., Massardier, J., Demede, D., Perrotin, F., Cloarec, S., Vequeau-Goua, V., Descombes, E., Boulot, P., Morin, D., Fuchs, F., Tenenbaum, J., Ville, Y., Blanc, T., Heidet, L., Paris, A., Dobremez, E., Froute, M.F., Gondry, J., Muszynski, C., Haraux, E., Lobelle, F., Chevreau, J., Rosenblatt, J., Baudoin, V., Deschenes, G., Guigue, V., Amblard, F., Bourdat-Michel, G., Wühl, E., Schaefer, F., Elsässer, M., Persico, N., Rossi, F., Manzoni, G., De Marco, E.A., Montini, G., Capone, V., Caforio, L., Zaccara, A., Innocenzi, M., Bagolan, P., Capozza, N., Castagnetti, M., Mancini, M., Oepkes, D., van Scheltema, P.A., Feitz, W., Kortmann, B., Schreuder, M., Tkaczyk, M., Stańczyk, M., Szaflik, K., Wojtera, J., Krzeszowski, W., Talar, T., Pawłowska, B., Fortecka-Piestrzeniewicz, K., Olejniczak, D., Ariceta, G., Arevalo, S., Rodo, C., Fossum, M., Lindgren, P., Parvex, P., Chehade, H., Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Radboud University Medical Center [Nijmegen], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), HybridStat Predictive Analytics [Athens, Greece], Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospitals Leuven [Leuven], Heidelberg University Hospital [Heidelberg], University of Milan, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico [Milan, Italy], Leiden University Medical Center (LUMC), Radboud Institute for Molecular Life Sciences [Nijmegen, the Netherlands], Polish Mother’s Memorial Hospital Research Institute [Lodz] (ICZMP), Pediatric Nephrology [Barcelona, Spain] (Vall d’Hebron Hospital), Universitat Autònoma de Barcelona (UAB)-Vall d'Hebron University Hospital [Barcelona], Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Geneva University Hospital (HUG), Aarhus University Hospital, Aarhus University [Aarhus], Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, ANTENATAL Consortium: An Hindryckx, Luc De Catte, Christophe Vayssieres, Agnès Sartor, Marion Groussolles, Christelle Plard, Paul Guerby, Laure Connan, Mathieu Morin, Elizabeth Simon, Jean Breaud, Anne-Hélène Saliou, Loic De Parscau, Nadine Jay, Isabelle Germouty, Gwenaelle Le Bouar, Amelie Ryckewaert, Marie-Christine Manca-Pellissier, Thierry Merrot, Helene Laurichesse, Denis Gallot, Lucie Bessenay, Laurent Bidat, Philippe Boize, Norbert Winer, Emma Allain-Launey, Claudine Le Vaillant, Fabienne Prieur, Marie-Pierre Lavocat, Frederic Coatleven, Eric Debromez, Jérôme Harembat, Brigitte Llanas, Romain Favre, Raphael Moog, Ariane Zaloszyc, Jérôme Massardier, Delphine Demede, Franck Perrotin, Sylvie Cloarec, Valérie Vequeau-Goua, Emmanuelle Descombes, Pierre Boulot, Denis Morin, Florent Fuchs, Julie Tenenbaum, Yves Ville, Thomas Blanc, Laurence Heidet, Anne Paris, Eric Dobremez, Marie-Françoise Froute, Jean Gondry, Charles Muszynski, Elodie Haraux, Fabienne Lobelle, Julien Chevreau, Jonathan Rosenblatt, Véronique Baudoin, Georges Deschenes, Virginie Guigue, Florence Amblard, Guylhène Bourdat-Michel, Elke Wühl, Franz Schaefer, Michael Elsässer, Nicola Persico, Federica Rossi, Gianantonio Manzoni, Erika A De Marco, Giovanni Montini, Valentina Capone, Leonardo Caforio, Antonio Zaccara, Michele Innocenzi, Pietro Bagolan, Nicola Capozza, Marco Castagnetti, Mariangela Mancini, Dick Oepkes, Phebe Adama van Scheltema, Wout Feitz, Barbara Kortmann, Michiel Schreuder, Marcin Tkaczyk, Małgorzata Stańczyk, Krzysztof Szaflik, Justyna Wojtera, Waldemar Krzeszowski, Tomasz Talar, Barbara Pawłowska, Katarzyna Fortecka-Piestrzeniewicz, Dariusz Olejniczak, Gema Ariceta, Silvia Arevalo, Carlota Rodo, Magdalena Fossum, Peter Lindgren, Paloma Parvex, Hassib Chehade., Schanstra, Joost, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Università degli Studi di Milano = University of Milan (UNIMI)

Subjects
Posterior urethral valve, medicine.medical_specialty, Urinary system, [SDV]Life Sciences [q-bio], kidney disease, prenatal biomarkers, Renal function, Prenatal care, 030204 cardiovascular system & hematology, DIAGNOSIS, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Medicine, obstructive uropathy, Obstructive uropathy, development, 030304 developmental biology, RISK, 0303 health sciences, Transplantation, Kidney, ddc:618, Science & Technology, business.industry, Obstetrics, Original Articles, prediction, Urology & Nephrology, Omics, medicine.disease, 6. Clean water, 3. Good health, [SDV] Life Sciences [q-bio], Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], medicine.anatomical_structure, Nephrology, embryonic structures, Settore MED/20, URINARY-TRACT OBSTRUCTION, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business, Life Sciences & Biomedicine, Kidney disease
Abstract

Altres ajuts: The study is partially made possible by support of the 'Programme Hospitalier de Recherche Clinique and 'La Foundation de la Recherche Médicale (grant number DEQ20170336759, France). M.T. was supported by the Polish Mothers Memorial Hospital Research Institute (internal grant number 2016/IV/54-GW. LvdZ is supported by a Kolff grant from the Dutch Kidney Foundation (13OKJ36) and a ZonMW-VENI grant from the Netherlands Organisation for Scientific Research (91618036). This project has been supported by ERN ERKNet and ERN eUROGEN, which are partly co-funded by the European Union within the framework of the Third Health Programme 'ERN-2016-Framework Partnership Agreement 2017-2021'. Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1-β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV.

Published
2020
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