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1,426 results on '"Octavio M"'

55. Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial.

Author

Ouyang, Menglu, Anjum, Anila, Mc Cawley, Francisca Gonzalez, Wasay, Mohammad, Ma, Lu, Hu, Xin, Chen, Xiaoying, Malavera, Alejandra, Li, Xi, Venturelli, Paula Muñoz, Silva, H. Asita de, Thang, Nguyen Huy, Wahab, Kolawole W., Pandian, Jeyaraj D., Pontes-Neto, Octavio M., Abanto, Carlos, Cano-Nigenda, Venessa, Arauz, Antonio, You, Chao, and Jan, Stephen

Published
2024
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56. Orthopteran Neo‐Sex Chromosomes Reveal Dynamics of Recombination Suppression and Evolution of Supergenes.

Author

Jayaprasad, Suvratha, Peona, Valentina, Ellerstrand, Simon J., Rossini, Roberto, Bunikis, Ignas, Pettersson, Olga V., Olsen, Remi‐André, Rubin, Carl‐Johan, Einarsdottir, Elisabet, Bonath, Franziska, Bradford, Tessa M., Cooper, Steven J. B., Hansson, Bengt, Suh, Alexander, Kawakami, Takeshi, Schielzeth, Holger, and Palacios‐Gimenez, Octavio M.

Subjects
SEX chromosomes, SEX determination, CHROMOSOMAL rearrangement, KARYOTYPES, CHROMOSOMES, Y chromosome
Abstract

The early evolution of sex chromosomes has remained obscure for more than a century. The Vandiemenella viatica species group of morabine grasshoppers is highly suited for studying the early stages of sex chromosome divergence and degeneration of the Y chromosome. This stems from the fact that neo‐XY sex chromosomes have independently evolved multiple times by X‐autosome fusions with different autosomes. Here, we generated new chromosome‐level assemblies for two chromosomal races representing karyotypes with and without neo‐sex chromosomes (P24XY and P24X0), and sequence data of a third chromosomal race with a different neo‐XY chromosome system (P25XY). Interestingly, these two neo‐XY chromosomal races are formed by different X‐autosome fusions (involving chr1 and chrB, respectively), and we found that both neo‐Y chromosomes have partly ceased to recombine with their neo‐X counterpart. We show that the neo‐XY chromosomes have diverged through accumulation of SNPs and structural mutations, and that many neo‐Y‐linked genes have degenerated since recombination ceased. However, the non‐recombining regions of neo‐Y chromosomes host non‐degenerated genes crucial for sex determination, such as sex‐lethal and transformer, alongside genes associated with spermatogenesis, fertility, and reproduction, illustrating their integrative role as a masculinizing supergene. Contrary to expectations, the neo‐Y chromosomes showed (slightly) lower density of transposable elements (TEs) compared to other genomic regions. The study reveals the unique dynamics of young sex chromosomes, with evolution of recombination suppression and pronounced decay of (some) neo‐sex chromosome genes, and provides a compelling case illustrating how chromosomal fusions and post‐fusion mutational processes contribute to the evolution of supergenes. [ABSTRACT FROM AUTHOR]

Published
2024
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58. Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial

Author

Anderson, Craig S., Huang, Yining, Lindley, Richard I., Chen, Xiaoying, Arima, Hisatomi, Chen, Guofang, Li, Qiang, Billot, Laurent, Delcourt, Candice, Bath, Philip M., Broderick, Joseph P., Demchuk, Andrew M., Donnan, Geoffrey A., Durham, Alice C., Lavados, Pablo M., Lee, Tsong-Hai, Levi, Christopher, Martins, Sheila O., Olavarria, Veronica V., Pandian, Jeyaraj D., Parsons, Mark W., Pontes-Neto, Octavio M., Ricci, Stefano, Sato, Shoichiro, Sharma, Vijay K., Silva, Federico, Song, Lili, Thang, Nguyen H., Wardlaw, Joanna M., Wang, Ji-Guang, Wang, Xia, Woodward, Mark, Chalmers, John, Robinson, Thompson G., Kim, Jong S., Stapf, Christian, Simes, R. John, Hankey, Graeme J., Sandercock, Peter, Bousser, Marie-Germaine, Wong, K.S. Lawrence, Scaria, Anish, Hirakawa, Yoichiro, Moullaali, Tom J., Carcel, Cheryl, Gordon, Penny, Fuentes-Patarroyo, Sully X., Benito, Dino, Chen, Ruiqi, Cao, Yongjun, Kunchok, Amy, Winters, Stephen, Coutts, Shelagh, Yoshimura, Sohei, You, Shoujiang, Yang, Jie, Wu, Guojun, Zhang, Shihong, Manning, Lisa, Mistri, Amit, Haunton, Victoria, Minhas, Jatinder, Malavera, Alejandra, Lim, Joyce, Liu, Leibo, Kumar, Namrata N., Tay, Nicole, Jenson, Kerry, Richtering, Sarah, Tucker, Sharon, Knight, Elizabeth, Ivanova, Elizaveta, Thembani, Emma, Odgers, Elizabeth, Sanders, Elizabeth, Small, Sabrina, Vaghasiya, Ruchita, Armenis, Manuela, Donnelly, Paul, Baig, Merza A., Blacklock, Nick, Naidu, Bala, Monaghan, Helen, Smith, Phillipa, Glass, Parisa, Bai, Xuejie, Li, Qiancheng, Zhu, Pingping, Kong, Liang, He, Ruihong, Zhao, He, Lv, Jiajie, Jia, Haijing, Xi, Zhen, Cong, Yuhan, Cui, Buliang, Deng, Hua, Guo, Ying, He, Lingyu, Jia, Ruolan, Li, Nan, Li, Wei, Liu, Mengxiao, Zhang, Meng, Xu, Ziwei, Zhang, Ting, Zhao, Yan, Gregory, Philip, In, Yunjeong, Kim, Su J., Ahn, Jung E., Kim, Sul H., Hong, Young L., González-McCawley, Francisca, Martins, Magda C.O., Portales, Bernardita, Wang, Ching-Yi, Ryu, Shan-Jen, Aujla, Hardeep, Lewin, Sue, Kumar, Tracy, Barrows, Sara, Ebraimo, Ahtasam, Uyen, Hong H., Giang, Nguyen A., Linh, Le T.M., An, Le T.T., Phuong, Do M., Ngoc, Pham V.B., Hang, Nguyen M., Tran, Nguyen T.B., Hien, Ha T.T., Yen, Mai B., Tram, Ngo T.B., Truc, Tran T.T., Hoa, Nguyen A., Thuan, Nguyen T.B., Oanh, Ha T.K., Arora, Deepti, Verma, Shweta J., Krause, M., Priglinger, M., Day, S., Jala, S., Davies, L., Ray, E., Celestino, S., Law, L.Y., Wijeratne, T., Ng, G., Nagao, K., Weiss, G., Titton, N., Batista, C., Zãn, D., Carbonera, L., Ferreira, K., Castro, R., Martins Filho, R.K., Carvalho, M., Libardi, M., Martins, G., Fagundes, D., Baron, G., Boehringer, A., Barbosa, J., Bazan, R., Braga, G., Luvizutto, G., Ribeiro, P., Winckler, F., Moro, C., Longo, A., Liberato, R., Barbosa, R., Magalhães, P., Portal, M., Martin, K., Souza, A., Cuervo, D., Perin, D., Marques, L., Oliveira, F., Battaglini, M., Lourenço, F., Silva, G., Duarte, L., Alves, M., Sousa, J., Uhehara, M., Brunser, A., Mazzón, E., Spencer, M., Acosta, I., Rojo, A., Rivas, R., Klapp, C., Carvallo, L., Carvallo, P., Mansilla, E., Flores, J., Alvarado, M., Herrera, A., Reyes, C., Jurado, F., Bustamante, G., Bravo, L., Matamala, J.M., Guerrero, R., Zhou, S., Ping, L., Liu, W., Liu, L., Tian, Y., Xu, H., Wang, J., Wang, L., Zhen, Z., Zhang, J., Yan, M., Zhang, Q., Tao, X., Liu, C., Shi, J., Zhang, X., Tai, L., Xu, L., Lu, H., Nie, H., Li, X., Zhou, J., Liu, Y., Gong, P., Zhao, H., Li, R., Wang, X., Chen, Q., Li, Y., Wu, L., Jia, L., Guo, X., Chen, G., Lin, B., Zhu, W., Yang, K., Zhang, Z., Xie, C., Wu, D., Wang, Y., Liu, D., Liu, Z., Liang, L., Cao, Q., Xia, J., Weng, Y., Li, J., Xu, T., Geng, D., Yan, X., Wang, D., Zhao, N., Tang, Z., Yin, W., Wang, S., Huang, W., Yang, Y., Song, A., Hao, Y., Zhang, A., Qiao, B., Yang, J., Yan, H., Wei, X., Tao, Z., Liu, H., Lv, Y., Yang, H., Han, L., Mao, X., Ge, L., Zhang, Y., He, S., Jiang, J., Wu, W., Wang, H., Yang, L., Tang, Y., Sun, H., Li, F., Li, G., Sun, Y., Zhang, H., Wu, Y., Huang, L., Geng, C., Jin, Z., Zhu, J., Zhang, F., Zheng, R., Shen, H., Liu, F., Chen, C., Chen, S., Zhou, L., Hu, B., Zou, Z., Liu, J., Chang, X., Zhang, S., Huang, Q., Liu, X., Liu, S., He, W., Feng, J., Li, L., Chen, X., Zhuang, X., Zheng, W., Lai, Y., Zhou, Y., Duan, H., Yang, Q., Du, J., Lin, Q, Xu, E., Zhan, L., Wu, J., Feng, X., Wei, C., He, J., Wang, B., Li, W, Chen, P, Guo, F, Dai, H, Dai, M, Zeng, X., Chen, B., Long, F., Su, Q., Bao, B., Wu, T., Wu, X., Shao, Y., Li, S., Xu, Y., Castellanos, J.A., Muñoz-Collazos, M., Solano, E., Leung, W.H.T., Sureshbabu, S., Sharma, S.N., George, S., Shekhar, S., Singla, S., Saini, L., Sunita, Kate, M., Sarvotham, R., William, A.G., Deepak, A., BK, M., Benny, R., Bolegave, V., Basle, M., Gore, S., George, P., Kumaravelu, S., Rahamath, S., Raj, P.G., Devi, A.R., Sharma, A., Prajapati, J., Parmar, M., Patel, D., Panchal, T., Gorthi, S.P., Prabhu, V., Prabhu, A., Chandran, V., Chatterjee, A., Nair, R., Nambiar, V.K., TS, D., TP, S., Ajai, V., Paul, S., Natarajan, P.C., Chittibabu, D., Borah, N.C., Ghose, M., Choudhury, N., Gohain, P., Kalita, K., Duberkar, D., Pawar, N., Bhaviskar, R., Caterbi, E., Cenciarelli, S., Condurso, R., Gallinella, E., Greco, L., Marando, C., Mastrocola, S., Mattioni, A., Sacchini, E., Sicilia, I., Gallina, A., Giannandrea, D., Marsili, E., Mazzoli, T., Padiglioni, C., Corea, F., Guidubaldi, A., Micheli, S., Barbi, M., Kim, J., Song, H.J., Jeong, H.S., Lim, J.G., Park, S.M., Lee, K.B., Hwang, H.W., Kwon, S.U., Kang, D.W., Kim, Y.J., Kim, B.J., Park, J.M., Kang, K., Kim, B., Kwon, O., Kim, Y.W., Lee, J.J., Hwang, Y.H., Kwon, H.S., Koo, J., Lee, K., Kim, T., Ahn, A., Rha, J.H., Park, H.K., Yoon, C.W., Chan, B., Teoh, H.L., Paliwal, P., Wong, L.Y.J., Chen, J.T., De Silva, D.A., Chang, H.M., Fabiaña, N., Marti, J., Delgado, R., Martínez, A., Prats, L., Camps, P., Liou, C.W., Tan, T.Y., Liu, C.F., Cheng, H.H., Po, H.L., Lin, Y.J., Chou, C.L., Lin, C.H., Yen, C.C., Chang, Y.T., Hsu, Y.T., Lee, J.D., Lee, M., Huang, Y.C., Wu, C.Y., Suwanwela, N.C., Chutinet, A., Likitjaroen, Y., Roongpiboonsopit, D., Charnwut, S., Dyker, A., Hossain, M., Muddegowda, G.K., Sanyal, R., Roffe, C., Natarajan, I., Finney, K., Sztriha, L., Teo, J., Chan, F.K., Lim, J., Chitando, B., Clarke, B., Patel, B., Khan, U., Ghatala, R., Trippier, S., Kalra, L., Manawadu, D., Sikondari, N., Aeron-Thomas, J., Sunman, W., Wilkes, G., Richardson, C., Buch, A., Jackson, B., Halse, O., Mashate, S., Wilding, P., Nguyen, V., Qadiri, M.R., Rashed, K., Board, S., Buckley, C., Smith, C., James, M., Keenan, S., Bouring, A., England, T., Donnelly, R., Scott, J., Maddula, M., Beavan, J., Perry, R., Francia, N., Watchhurst, C., Banaras, A., Ashton, A., Mistri, A., Musarrat, K., Eveson, D., Kallingal, J., Perez, J., Harrison, L., Marsden, T., Furnace, J., Clarke, R., Reid, J., Warburton, E., Macleod, M.J., Mitchell, J., Day, D., Church, N., Amis, E., Price, C., Rodgers, H., Whiting, R., Hussain, M., Harvey, M., Brown, S., Foot, J., Tryambake, D., Broughton, D., Bergin, A., Annamalai, A., Dixon, L., Weir, N., Blank, C., Harkness, K., Ali, A., Richards, E., Stocks, K., Bruce, D.W., Wani, M., Anjum, T., Krishnan, M., Nguyen Huy, T., Le Tuan, A. Truong, Cam, L. Dam Thi, Kim, T. Ngo Thi, Nguyen, B. Pham, Dat, A. Nguyen, Van, C. Nguyen, Duy, T. Mai, Viet, P. Dao, Tien, D. Nguyen, Van, T. Vo, Le Kim, K., Ngoc, T. Bui, Le Thanh, T. Tran, Hoanh, S. Nguyen, Phuoc, S. Pham, Van, T. Tran, Thi, B. Doan, Thu, H. Nguyen Thi, Duy, M. Nguyen, Van, D. Ngo, Anderson, Craig S, Lindley, Richard I, Bath, Philip M, Broderick, Joseph P, Demchuk, Andrew M, Donnan, Geoffrey A, Durham, Alice C, Lavados, Pablo M, Martins, Sheila O, Olavarria, Veronica V, Pandian, Jeyaraj D, Parsons, Mark W, Pontes-Neto, Octavio M, Sharma, Vijay K, Thang, Nguyen H, Wardlaw, Joanna M, and Robinson, Thompson G

Published
2019
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59. Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Author

Halliday, Alison, Bulbulia, Richard, Bonati, Leo H, Peto, Richard, Pan, Hongchao, Potter, John, Henning Eckstein, Hans, Farrell, Barbara, Flather, Marcus, Mansfield, Averil, Mihaylova, Boby, Rahimi, Kazim, Simpson, David, Thomas, Dafydd, Sandercock, Peter, Gray, Richard, Molyneux, Andrew, Shearman, Cliff P, Rothwell, Peter, Belli, Anna, Herrington, Will, Judge, Parminder, Leopold, Peter, Mafham, Marion, Gough, Michael, Cao, Piergiorgio, MacDonald, Sumaira, Bari, Vasha, Berry, Clive, Bradshaw, S, Brudlo, Wojciech, Clarke, Alison, Chester, Johanna, Cox, Robin, Cradduck-Bamford, Andrea, Fathers, Susan, Gaba, Kamran, Gray, Mo, Hayter, Elizabeth, Holliday, Constance, Kurien, Rijo, Lay, Michael, le Conte, Steffi, McManus, Jessica, Madgwick, Zahra, Morris, Dylan, Munday, Andrew, Pickworth, Sandra, Ostasz, Wiktor, Poorthuis, Michiel, Richards, Sue, Teixeira, Louisa, Tochlin, Sergey, Tully, Lynda, Wallis, Carol, Willet, Monique, Young, Alan, Casana, Renato, Malloggi, Chiara, Odero Jr, Andrea, Silani, Vincenzo, Parati, Gianfranco, Malchiodi, Giuseppe, Malferrari, Giovanni, Strozzi, Francesco, Tusini, Nicola, Vecchiati, Enrico, Coppi, Gioacchino, Lauricella, Antonio, Moratto, Roberto, Silingardi, Roberto, Veronesi, Jessica, Zini, Andrea, Ferrero, Emanuele, Ferri, Michelangelo, Gaggiano, Andrea, Labate, Carmelo, Nessi, Franco, Psacharopulo, Daniele, Viazzo, Andrea, Malacrida, Giovanni, Mazzaccaro, Daniela, Meola, Giovanni, Modafferi, Alfredo, Nano, Giovanni, Occhiuto, Maria Teresa, Righini, Paolo, Stegher, Silvia, Chiarandini, Stefano, Griselli, Filippo, Lepidi, Sandro, Pozzi Mucelli, Fabio, Naccarato, Marcello, D'Oria, Mario, Ziani, Barbara, Stella, Andrea, Dieng, Mortalla, Faggioli, Gianluca, Gargiulo, Mauro, Palermo, Sergio, Pini, Rodolfo, Puddu, Giovanni Maria, Vacirca, Andrea, Angiletta, Domenico, Desantis, Claudio, Marinazzo, Davide, Mastrangelo, Giovanni, Regina, Guido, Pulli, Raffaele, Bianchi, Paolo, Cireni, Lea, Coppi, Elisabetta, Pizzirusso, Rocco, Scalise, Filippo, Sorropago, Giovanni, Tolva, Valerio, Caso, Valeria, Cieri, Enrico, DeRango, Paola, Farchioni, Luca, Isernia, Giacomo, Lenti, Massimo, Parlani, Gian Battista, Pupo, Guglielmo, Pula, Grazia, Simonte, Gioele, Verzini, Fabio, Carimati, Federico, Delodovici, Maria Luisa, Fontana, Federico, Piffaretti, Gabriele, Tozzi, Matteo, Civilini, Efrem, Poletto, Giorgio, Reimers, Bernhard, Praquin, Barbara, Ronchey, Sonia, Capoccia, Laura, Mansour, Wassim, Sbarigia, Enrico, Speziale, Francesco, Sirignano, Pasqualino, Toni, Danilo, Galeotti, Roberto, Gasbarro, Vincenzo, Mascoli, Francesco, Rocca, Tiberio, Tsolaki, Elpiniki, Bernardini, Giulia, DeMarco, Ester, Giaquinta, Alessia, Patti, Francesco, Veroux, Massimiliano, Veroux, Pierfrancesco, Virgilio, Carla, Mangialardi, Nicola, Orrico, Matteo, Di Lazzaro, Vincenzo, Montelione, Nunzio, Spinelli, Francesco, Stilo, Francesco, Cernetti, Carlo, Irsara, Sandro, Maccarrone, Giuseppe, Tonello, Diego, Visonà, Adriana, Zalunardo, Beniamino, Chisci, Emiliano, Michelagnoli, Stefano, Troisi, Nicola, Masato, Maela, Dei Negri, Massimo, Pacchioni, Andrea, Saccà, Salvatore, Amatucci, Giovanni, Cannizzaro, Alfredo, Accrocca, Federico, Ambrogi, Cesare, Barbazza, Renzo, Marcucci, Giustino, Siani, Andrea, Bajardi, Guido, Savettieri, Giovanni, Argentieri, Angelo, Corbetta, Riccardo, Odero, Attilio, Quaretti, Pietro, Thyrion, Federico Z, Cappelli, Alessandro, Benevento, Domenico, De Donato, Gianmarco, Mele, Maria Agnese, Palasciano, Giancarlo, Pieragalli, Daniela, Rossi, Alessandro, Setacci, Carlo, Setacci, Francesco, Palombo, Domenico, Perfumo, Maria Cecilia, Martelli, Edoardo, Paolucci, Aldo, Trimarchi, Santi, Grassi, Viviana, Grimaldi, Luigi, La Rosa, Giuliana, Mirabella, Domenico, Scialabba, Matteo, Sichel, Leonildo, D'Angelo, Costantino L, Fadda, Gian Franco, Kasemi, Holta, Marino, Mario, Burzotta, Francesco, Codispoti, Francesco Alberto, Ferrante, Angela, Tinelli, Giovanni, Tshomba, Yamume, Vincenzoni, Claudio, Amis, Deborah, Anderson, Dawn, Catterson, Martin, Clarke, Mike, Davis, Michelle, Dixit, Anand, Dyker, Alexander, Ford, Gary, Jackson, Ralph, Kappadath, Sreevalsan, Lambert, David, Lees, Tim, Louw, Stephen, McCaslin, James, Parr, Noala, Robson, Rebecca, Stansby, Gerard, Wales, Lucy, Wealleans, Vera, Wilson, Lesley, Wyatt, Michael, Baht, Hardeep, Balogun, Ibrahim, Burger, Ilse, Cosier, Tracy, Cowie, Linda, Gunathilagan, Gunaratnam, Hargroves, David, Insall, Robert, Jones, Sally, Rudenko, Hannah, Schumacher, Natasha, Senaratne, Jawaharlal, Thomas, George, Thomson, Audrey, Webb, Tom, Brown, Ellen, Esisi, Bernard, Mehrzad, Ali, MacSweeney, Shane, McConachie, Norman, Southam, Alison, Sunman, Wayne, Abdul-Hamiq, Ahmed, Bryce, Jenny, Chetter, Ian, Ettles, Duncan, Lakshminarayan, Raghuram, Mitchelson, Kim, Rhymes, Christopher, Robinson, Graham, Scott, Paul, Vickers, Alison, Ashleigh, Ray, Butterfield, Stephen, Gamble, Ed, Ghosh, Jonathan, McCollum, Charles N, Welch, Mark, Welsh, Sarah, Wolowczyk, Leszek, Donnelly, Mary, D'Souza, Stephen, Egun, Anselm A, Gregary, Bindu, Joseph, Thomas, Kelly, Christine, Punekar, Shuja, Rahi, M Asad, Raj, Sonia, Seriki, Dare, Thomson, George, Brown, James, Durairajan, Ragunath, Grunwald, Iris, Guyler, Paul, Harman, Paula, Jakeways, Matthew, Khuoge, Christopher, Kundu, Ashish, Loganathan, Thayalini, Menon, Nisha, Prabakaran, Raji O, Sinha, Devesh, Thompson, Vicky, Tysoe, Sharon, Briley, Dennis, Darby, Chris, Hands, Linda, Howard, Dominic, Kuker, Wilhelm, Schulz, Ursula, Teal, Rachel, Barer, David, Brown, Andrew, Crawford, Susan, Dunlop, Paul, Krishnamurthy, Ramesh, Majmudar, Nikhil, Mitchell, Duncan, Myint, Min P, O'Brien, Richard, O'Connell, Janice, Sattar, Naweed, Vetrivel, Shanmugam, Beard, Jonathan, Cleveland, Trevor, Gaines, Peter, Humphreys, John, Jenkins, Alison, King, Craig, Kusuma, Daniel, Lindert, Ralph, Lonsdale, Robbie, Nair, Raj, Nawaz, Shah, Okhuoya, Faith, Turner, Douglas, Venables, Graham, Dorman, Paul, Hughes, Andrea, Jones, Deborah, Mendelow, David, Rodgers, Helen, Raudoniitis, Aidas, Enevoldson, Peter, Nahser, Hans, O'Brien, Imelda, Torella, Francesco, Watling, Dave, White, Richard, Brown, Pauline, Dutta, Dipankar, Emerson, Lorraine, Hilltout, Paula, Kulkarni, Sachin, Morrison, Jackie, Poskitt, Keith, Slim, Fiona, Smith, Sarah, Tyler, Amanda, Waldron, Joanne, Whyman, Mark, Bajoriene, Milda, Baker, Lucy, Colston, Amanda, Eliot-Jones, Bekky, Gramizadeh, Gita, Lewis-Clarke, Catherine, McCafferty, Laura, Oliver, Deborah, Palmer, Debbie, Patil, Abhijeet, Pegler, Suzannah, Ramadurai, Gopi, Roberts, Aisling, Sargent, Tracey, Siddegowda, Shivaprasad, Singh-Ranger, Ravi, Williams, Akintunde, Williams, Lucy, Windebank, Steve, Zuromskis, Tadas, Alwis, Lanka, Angus, Jane, Asokanathan, Asaipillai, Fornolles, Caroline, Hardy, Diana, Hunte, Sophy, Justin, Frances, Phiri, Duke, Mitabouana-Kibou, Marie, Sekaran, Lakshmanan, Sethuraman, Sakthivel, Tate, Margaret L, Akyea-Mensah, Joyce, Ball, Stephen, Chrisopoulou, Angela, Keene, Elizabeth, Phair, Alison, Rogers, Steven, Smyth, John V, Bicknell, Colin, Chataway, Jeremy, Cheshire, Nicholas, Clifton, Andrew, Eley, Caroline, Gibbs, Richard, Hamady, Mohammad, Hazel, Beth, James, Alex, Jenkins, Michael, Khanom, Nyma, Lacey, Austin, Mireskandari, Maz, O'Reilly, Joanna, Pereira, Antony, Sachs, Tina, Wolfe, John, Davey, Philip, Rogers, Gill, Smith, Gemma, Tervit, Gareth, Nichol, Ian, Parry, Andrew, Young, Gavin, Ashley, Simon, Barwell, James, Dix, Francis, Nor, Azlisham M, Parry, Chris, Birt, Angela, Davies, Paul, George, Jim, Graham, Anne, Jonker, Leon, Kelsall, Nicci, Potts, Caroline, Wilson, Toni, Crinnion, Jamie, Cuenoud, Larissa, Aleksic, Nikola, Babic, Srdan, Ilijevski, Nenad, Radak, Đorde, Sagic, Dragan, Tanaskovic, Slobodan, Colic, Momcilo, Cvetic, Vladimir, Davidovic, Lazar, Jovanovic, Dejana R, Koncar, Igor, Mutavdžic, Perica, Sladojevic, Miloš, Tomic, Ivan, Debus, Eike S, Grzyska, Ulrich, Otto, Dagmar, Thomalla, Götz, Barlinn, Jessica, Gerber, Johannes, Haase, Kathrin, Hartmann, Christian, Ludwig, Stefan, Pütz, Volker, Reeps, Christian, Schmidt, Christine, Weiss, Norbert, Werth, Sebastian, Winzer, Simon, Gemper, Janine, Günther, Albrecht, Heiling, Bianka, Jochmann, Elisabeth, Karvouniari, Panagiota, Klingner, Carsten, Mayer, Thomas, Schubert, Julia, Schulze-Hartung, Friederike, Zanow, Jürgen, Bausback, Yvonne, Borger, Franka, Botsios, Spiridon, Branzan, Daniela, Bräunlich, Sven, Hölzer, Henryk, Lenzer, Janin, Piorkowski, Christopher, Richter, Nadine, Schuster, Johannes, Scheinert, Dierk, Schmidt, Andrej, Staab, Holger, Ulrich, Matthias, Werner, Martin, Berger, Hermann, Biró, Gábor, Eckstein, Hans-Henning, Kallmayer, Michael, Kreiser, Kornelia, Zimmermann, Alexander, Berekoven, Bärbel, Frerker, Klaus, Gordon, Vera, Torsello, Giovanni, Arnold, Sebastian, Dienel, Cora, Storck, Martin, Biermaier, Bernhard, Gissler, Hans Martin, Klötzsch, Christof, Pfeiffer, Tomas, Schneider, Ralph, Söhl, Leander, Wennrich, Michael, Alonso, Angelika, Keese, Michael, Groden, Christoph, Cöster, Andreas, Engelhardt, Andreas, Ratusinski, Christoph-Maria, Berg, Bengt, Delle, Martin, Formgren, Johan, Gillgren, Peter, Jarl, Lotta, Kall, Torbjörn B, Konrad, Peter, Nyman, Niklas, Skiöldebrand, Claes, Steuer, Johnny, Takolander, Rabbe, Malmstedt, Jonas, Acosta, Stefan, Björses, Katarina, Brandt, Kerstin, Dias, Nuno, Gottsäter, Anders, Holst, Jan, Kristmundsson, Thorarinn, Kühme, Tobias, Kölbel, Tilo, Lindblad, Bengt, Lindh, Mats, Malina, Martin, Ohrlander, Tomas, Resch, Tim, Rönnle, Viola, Sonesson, Björn, Warvsten, Margareta, Zdanowski, Zbigniew, Campbell, Erik, Kjellin, Per, Lindgren, Hans, Nyberg, Johan, Petersen, Björn, Plate, Gunnar, Pärsson, Håkan, Qvarfordt, Peter, Ignatenko, Pavel, Karpenko, Andrey, Starodubtsev, Vladimir, Chernyavsky, Mikhail A, Golovkova, Maria S, Komakha, Boris B, Zherdev, Nikolay N, Belyasnik, Andrey, Chechulov, Pavel, Kandyba, Dmitry, Stepanishchev, Igor, Csobay-Novák, Csaba, Dósa, Edit, Entz, László, Nemes, Balázs, Szeberin, Zoltán, Barzó, Pál, Bodosi, Mihaly, Fákó, Eniko, Fülöp, Béla, Németh, Tamás, Pazdernyik, Szilárd, Skoba, Krisztina, Vörös, Erika, Chatzinikou, Eleni, Giannoukas, Athanasios, Karathanos, Christos, Koutsias, Stylianos, Kouvelos, Georgios, Matsagkas, Miltiadis, Ralli, Styliani, Rountas, Christos, Rousas, Nikolaos, Spanos, Konstantinos, Brountzos, Elias, Kakisis, John D, Lazaris, Andreas, Moulakakis, Konstantinos G, Stefanis, Leonidas, Tsivgoulis, Georgios, Vasdekis, Spyros, Antonopoulos, Constantine N, Bellenis, Ion, Maras, Dimitrios, Polydorou, Antonios, Polydorou, Victoria, Tavernarakis, Antonios, Ioannou, Nikolaos, Terzoudi, Maria, Lazarides, Miltos, Mantatzis, Michalis, Vadikolias, Kostas, Dzieciuchowicz, Lukasz, Gabriel, Marcin, Krasinski, Zbigniew, Oszkinis, Grzegorz, Pukacki, Fryderyk, Slowinski, Maciej, Stanišic, Michal-Goran, Staniszewski, Ryszard, Tomczak, Jolanta, Zielinski, Maciej, Myrcha, Piotr, Rózanski, Dorota, Drelichowski, Stanislaw, Iwanowski, Wojciech, Koncewicz, Katarzyna, Bialek, Pawel, Biejat, Zbigniew, Czepel, Wojciech, Czlonkowska, Anna, Dowzenko, Anatol, Jedrzejewska, Julia, Kobayashi, Adam, Leszczynski, Jerzy, Malek, Andrzej, Polanski, Jerzy, Proczka, Robert, Skorski, Maciej, Szostek, Mieczyslaw, Andziak, Piotr, Dratwicki, Maciej, Gil, Robert, Nowicki, Miroslaw, Pniewski, Jaroslaw, Rzezak, Jaroslaw, Seweryniak, Piotr, Dabek, Pawel, Juszynski, Michal, Madycki, Grzegorz, Pacewski, Bartosz, Raciborski, Witold, Slowinski, Piotr, Staszkiewicz, Walerian, Bombic, Martin, Chlouba, Vladimír, Fiedler, Jirí, Hes, Karel, Koštál, Petr, Sova, Jindrich, Kríž, Zdenek, Prívara, Mojmír, Reif, Michal, Staffa, Robert, Vlachovský, Robert, Vojtíšek, Bohuslav, Hrbác, Tomáš, Kuliha, Martin, Procházka, Václav, Roubec, Martin, Školoudík, David, Netuka, David, Šteklácová, Anna, Beneš III, Vladimír, Buchvald, Pavel, Endrych, Ladislav, Šercl, Miroslav, Campos Jr, Walter, Casella, Ivan B, de Luccia, Nelson, Estenssoro, André E V, Presti, Calógero, Puech-Leão, Pedro, Neves, Celso R B, da Silva, Erasmo S, Sitrângulo Jr, Cid J, Monteiro, José A T, Tinone, Gisela, Bellini Dalio, Marcelo, Joviliano, Edwaldo E, Pontes Neto, Octávio M, Serra Ribeiro, Mauricio, Cras, Patrick, Hendriks, Jeroen M H, Hoppenbrouwers, Mieke, Lauwers, Patrick, Loos, Caroline, Yperzeele, Laetitia, Geenens, Mia, Hemelsoet, Dimitri, van Herzeele, Isabelle, Vermassen, Frank, Astarci, Parla, Hammer, Frank, Lacroix, Valérie, Peeters, André, Verhelst, Robert, Cirelli, Silvana, Dormal, Pol, Grimonprez, Annelies, Lambrecht, Bart, Lerut, Philipe, Thues, Eddy, De Koster, Guy, Desiron, Quentin, Maertens de Noordhout, Alain, Malmendier, Danielle, Massoz, Mireille, Saad, Georges, Bosiers, Marc, Callaert, Joren, Deloose, Koen, Blanco Cañibano, Estrella, García Fresnillo, Beatriz, Guerra Requena, Mercedes, Morata Barrado, Pilar C, Muela Méndez, Miguel, Yusta Izquierdo, Antonio, Aparici Robles, Fernando, Blanes Orti, Paula, García Dominguez, Luis, Martínez López, Rafael, Miralles Hernández, Manuel, Tembl Ferrairo, José I, Chamorro, Ángel, Macho, Juan, Obach, Víctor, Riambau, Vincent, San Román, Luis, Ahlhelm, Frank J, Blackham, Kristine, Engelter, Stefan, Eugster, Thomas, Gensicke, Henrik, Gürke, Lorenz, Lyrer, Philippe, Mariani, Luigi, Maurer, Marina, Mujagic, Edin, Müller, Mandy, Psychogios, Marios, Stierli, Peter, Stippich, Christoph, Traenka, Christopher, Wolff, Thomas, Wagner, Benjamin, Wiegert, Martina M, Clarke, Sandra, Diepers, Michael, Gröchenig, Ernst, Gruber, Philipp, Isaak, Andrej, Kahles, Timo, Marti, Regula, Nedeltchev, Krassen, Remonda, Luca, Tissira, Nadir, Valença Falcão, Martina, de Borst, Gert J, Lo, Rob H, Moll, Frans L, Toorop, Raechel, van der Worp, Bart H, Vonken, Evert J, Kappelle, Jaap L, Jahrome, Ommid, Vos, Floris, Schuiling, Wouter, van Overhagen, Hendrik, Keunen, Rudolf W M, Knippenberg, Bob, Wever, Jan J, Lardenoije, Jan W, Reijnen, Michel, Smeets, Luuk, van Sterkenburg, Steven, Fraedrich, Gustav, Gizewski, Elke, Gruber, Ingrid, Knoflach, Michael, Kiechl, Stefan, Rantner, Barbara, Abdulamit, Timur, Bergeron, Patrice, Padovani, Raymond, Trastour, Jean-Christophe, Cardon, Jean-Marie, Le Gallou-Wittenberg, Anne, Allaire, Eric, Becquemin, Jean-Pierre, Cochennec-Paliwoda, Frédéric, Desgranges, Pascal, Hosseini, Hassan, Kobeiter, Hicham, Marzelle, Jean, Almekhlafi, Mohammed A, Bal, Simerpreet, Barber, Phillip A, Coutts, Shelagh B, Demchuk, Andrew M, Eesa, Muneer, Gillies, Michelle, Goyal, Mayank, Hill, Michael D, Hudon, Mark E, Jambula, Anitha, Kenney, Carol, Klein, Gary, McClelland, Marie, Mitha, Alim, Menon, Bijoy K, Morrish, William F, Peters, Steven, Ryckborst, Karla J, Samis, Greg, Save, Supriya, Smith, Eric E, Stys, Peter, Subramaniam, Suresh, Sutherland, Garnette R, Watson, Tim, Wong, John H, Zimmel, L, Flis, Vojko, Matela, Jože, Miksic, Kazimir, Milotic, Franko, Mrdja, Božidar, Stirn, Barbara, Tetickovic, Erih, Gasparini, Mladen, Grad, Anton, Kompara, Ingrid, Miloševic, Zoren, Palmiste, Veronika, Toomsoo, Toomas, Aidashova, Balzhan, Kospanov, Nursultan, Lyssenko, Roman, Mussagaliev, Daulet, Beyar, Rafi, Hoffman, Aaron, Karram, Tony, Kerner, Arthur, Nikolsky, Eugenia, Nitecki, Samy, Andonova, Silva, Bachvarov, Chavdar, Petrov, Vesko, Cvjetko, Ivan, Vidjak, Vinko, Halužan, Damir, Petrunic, Mladen, Liu, Bao, Liu, Chang-Wei, Bartko, Daniel, Beno, Peter, Rusnák, František, Zelenák, Kamil, Ezura, Masayuki, Inoue, Takashi, Kimura, Naoto, Kondo, Ryushi, Matsumoto, Yasushi, Shimizu, Hiroaki, Endo, Hidenori, Furui, Eisuke, Bakke, Søren, Krohg-Sørensen, Kristen, Nome, Terje, Skjelland, Mona, Tennøe, Bjørn, Albuquerque e Castro, João, Alves, Gonçalo, Bastos Gonçalves, Frederico, de Aragão Morais, José, Garcia, Ana C, Valentim, Hugo, Vasconcelos, Leonor, Belcastro, Fernando, Cura, Fernando, Zaefferer, Patricio, Abd-Allah, Foad, Eldessoki, Mohamed H, Heshmat Kassem, Hussein, Soliman Gharieb, Haytham, Colgan, Mary P, Haider, Syed N, Harbison, Joe, Madhavan, Prakash, Moore, Dermot, Shanik, Gregor, Kazan, Viviane, Nazzal, Munier, and Ramsey-Williams, Vicki

Published
2021
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65. Estatística Cardiovascular – Brasil 2023

Author

Oliveira, Gláucia Maria Moraes de, primary, Brant, Luisa Campos Caldeira, additional, Polanczyk, Carisi Anne, additional, Malta, Deborah Carvalho, additional, Biolo, Andreia, additional, Nascimento, Bruno Ramos, additional, Souza, Maria de Fatima Marinho de, additional, Lorenzo, Andrea Rocha De, additional, Fagundes, Antonio Aurélio de Paiva, additional, Schaan, Beatriz D., additional, Silva, Christina Grüne de Souza e, additional, Castilho, Fábio Morato de, additional, Cesena, Fernando Henpin Yue, additional, Soares, Gabriel Porto, additional, Xavier, Gesner Francisco, additional, Barreto, Jose Augusto Soares, additional, Passaglia, Luiz Guilherme, additional, Pinto, Marcelo Martins, additional, Machline-Carrion, M. Julia, additional, Bittencourt, Marcio Sommer, additional, Pontes, Octavio M., additional, Villela, Paolo Blanco, additional, Teixeira, Renato Azeredo, additional, Stein, Ricardo, additional, Sampaio, Roney Orismar, additional, Gaziano, Thomaz A., additional, Perel, Pablo, additional, Roth, Gregory A., additional, and Ribeiro, Antonio Luiz Pinho, additional

Published
2024
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68. Dynamic sex chromosome expression in Drosophila male germ cells

Author

Mahadevaraju, Sharvani, Fear, Justin M., Akeju, Miriam, Galletta, Brian J., Pinheiro, Mara M. L. S., Avelino, Camila C., Cabral-de-Mello, Diogo C., Conlon, Katie, Dell’Orso, Stafania, Demere, Zelalem, Mansuria, Kush, Mendonça, Carolina A., Palacios-Gimenez, Octavio M., Ross, Eli, Savery, Max, Yu, Kevin, Smith, Harold E., Sartorelli, Vittorio, Yang, Haiwang, Rusan, Nasser M., Vibranovski, Maria D., Matunis, Erika, and Oliver, Brian

Published
2021
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69. Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic

Author

Satoshi Yamada, Thomas G Devlin, David S Liebeskind, Michael D Hill, Tudor G Jovin, Jordi Blasco, Raul G Nogueira, John Thornton, Romain Bourcier, Robert Fahed, Michel Piotin, Salvatore Mangiafico, Maxim Mokin, Shadi Yaghi, Diogo C Haussen, Eytan Raz, Italo Linfante, Vitor Mendes Pereira, Monika Killer-Oberpfalzer, Alhamza R Al-Bayati, Patrick Nicholson, Georgios Tsivgoulis, Vanessa Chalumeau, Lissa Peeling, Xianjin Shang, Hao Zhang, Ajit S Puri, Osama O Zaidat, Santiago Ortega-Gutierrez, Dheeraj Gandhi, Gregory Walker, Kenichi Todo, Ameer E Hassan, Michael Chen, Nobuyuki Sakai, William J Mack, Simon Nagel, Pascal Jabbour, Michael Kelly, Don Frei, Hong Gee Roh, Fawaz Al-Mufti, Emma Griffin, Thanh N Nguyen, Alicia C Castonguay, Roberta Novakovic, Mohamad Abdalkader, Mario Martínez-Galdámez, Toshiyuki Fujinaka, Ken Wong, Daisuke Watanabe, Rishi Gupta, Sunil A Sheth, Melanie Walker, Hiroshi Yamagami, Brendan Steinfort, Alex Brehm, Johanna T Fifi, Nobuyuki Ohara, Yuichi Murayama, Ajay K Wakhloo, Wenguo Huang, Gianmarco Bernava, Paolo Machi, Nabeel Herial, Teddy Y Wu, Anna Luisa Kühn, Markus Möhlenbruch, James E Siegler, Stephan A Mayer, Takuya Kanamaru, André Beer-Furlan, Dileep Yavagal, Charles Matouk, Yuji Matsumaru, Pedro Lylyk, Allan Taylor, Leonardo Renieri, Pablo M Lavados, Verónica V Olavarría, Malveeka Sharma, Marios Psychogios, Laura Mechtouff, Vasu Saini, Jun Luo, Barbara Voetsch, Mudassir Farooqui, Ossama Y Mansour, Viktor Szeder, Jean Raymond, Muhammad M Qureshi, Michael Frankel, Zhongming Qiu, Omer F Eker, Fabricio Oliveira Lima, Francisco Mont'Alverne, Wazim Izzath, Mahmoud Mohammaden, David Ozretic, Saima Ahmad, Umair Rashid, Syed Irteza Hussain, Seby John, Jose Antonio Fiorot, Rodrigo Rivera, Nadia Hammami, Anna M Cervantes-Arslanian, Hormuzdiyar H Dasenbrock, Huynh Le Vu, Viet Quy Nguyen, Steven Hetts, Romain Guile, Atilla Ozcan Ozdemir, Ozlem Aykac, Chandril Chugh, Pascale Lavoie, Randall Edgell, Vikram Huded, Dong Hun Shin, Pedro SC Magalhaes, Raghid Kikano, Amal Abou-Hamden, Tatsuo Amano, Ryoo Yamamoto, Adrienne Weeks, Elena A Cora, Rotem Sivan-Hoffmann, Roberto Crosa, Hosam Al-Jehani, Victor S Lopez Rivera, Achmad Fidaus Sani, Daniel G Abud, Octavio M Pontes-Neto, Brijesh P Mehta, Naoto Kimura, Mamoru Murakami, Jin Soo Lee, Ji Man Hong, Eiji Hagashi, Steve M Cordina, Juan F Arenillas, Alejandro Rodriguez Vasquez, Luisa Fonseca, M Luis Silva, Simon John, Matthew Tenser, Tatemi Todaka, Miki Fujimura, Jun Deguchi, Yuri Sugiura, Hiroshi Tokimura, Rakesh Khatri, Hugh Stephen Winters, Johnny Wong, Mohamed Teleb, Jeremy Payne, Hiroki Fukuda, Kosuke Miyake, Junsuke Shimbo, Yusuke Sugimura, Masaaki Uno, Yohei Takenobu, Ryuhei Kono, Masafumi Morimoto, Junichi Iida, Saif Bushnaq, Jawad Kirmani, Ruchir Shah, Lee Birnbaum, Anchalee Churojana, Hesham E Masoud, Carlos Ynigo Lopez, Alice Ma, Amal Al Hashmi, Mollie McDermott, Alex Chebl, Odysseas Kargiotis, Jane G Morris, Clifford J Eskey, Jesse Thon, Leticia Rebello, Dorothea Altschul, Oriana Cornett, Varsha Singh, Jeyaraj Pandian, Anirudh Kulkarni, Yuki Yamamoto, Gisele Sampaio Silva, Serdar Geyik, Jasmine Johann, Sumeet Multani, Artem Kaliaev, Kazutaka Sonoda, Hiroyuki Hashimoto, Adel Alhazzani, David Y Chung, and Zhengzhou Yuan

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Background During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study’s objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before (1 year and immediately before) and during the pandemic, defined as 1 March–31 May 2020. The prior 1-year control period (1 March–31 May 2019) was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations, with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic, representing a relative decline of 22.5% (95% CI −24.3% to −20.7%, p

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70. Associations of Early Systolic Blood Pressure Control and Outcome After Thrombolysis-Eligible Acute Ischemic Stroke: Results From the ENCHANTED Study

Author

Wang, Xia, Minhas, Jatinder S., Moullaali, Tom J., Luca Di Tanna, Gian, Lindley, Richard I., Chen, Xiaoying, Arima, Hisatomi, Chen, Guofang, Delcourt, Candice, Bath, Philip M., Broderick, Joseph P., Demchuk, Andrew M., Donnan, Geoffrey A., Durham, Alice C., Lavados, Pablo M., Lee, Tsong-Hai, Levi, Christopher, Martins, Sheila O., Olavarria, Veronica V., Pandian, Jeyaraj D., Parsons, Mark W., Pontes-Neto, Octavio M., Ricci, Stefano, Sato, Shoichiro, Sharma, Vijay K., Silva, Federico, Thang, Nguyen H., Wang, Ji-Guang, Woodward, Mark, Chalmers, John, Song, Lili, Anderson, Craig S., and Robinson, Thompson G.

Published
2022
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72. The Diversity of Planetary Systems Architectures: Contrasting Theory with Observations

Author

Miguel, Yamila, Guilera, Octavio M., and Brunini, Adrian

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

We develop a semi-analytical model for computing planetary system formation with the aim of explaining the observed diversity of planetary systems architectures and relate this primordial diversity with the initial properties of the disc where they were born. We adopt different initial conditions based on recent results in protoplanetary discs observations, to generate a variety of planetary systems and analyze them statistically. We explore the relevance of the mass and size of the disc, its metallicity, the mass of the central star and the time-scale of gaseous disc dissipation, in defining the architecture of the planetary system. We also test different values of some key parameters of our model, to find out which factors best reproduce the diverse sample of observed planetary systems. According to this, we predict which systems are the most common in the solar neighbourhood. Our results show that planetary systems with only terrestrial planets are the most common, being the only planetary systems formed when considering low metallicity discs and which also represent the best environment for the developing of rocky, potentially habitable planets. We also found that planetary systems like our own are not rare in the solar neighbourhood, being its formation favoured in massive discs where there is not a large accumulation of solids in the inner region of the disc. Regarding the planetary systems that harbor hot and warm Jupiter planets, we found that this systems are born in very massive, metal-rich discs. Also a fast migration rate is required in order to form these systems. According to our results, most of the hot and warm Jupiter systems are composed by only one giant planet, which is also a tendency of the current observational data., Comment: MNRAS in press

Published
2011
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73. The role of the initial surface density profiles of the disc on giant planet formation: comparing with observations

Author

Miguel, Yamila, Guilera, Octavio M., and Brunini, Adrián

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

In order to explain the main characteristics of the observed population of extrasolar planets and the giant planets in the Solar System, we need to get a clear understanding of which are the initial conditions that allowed their formation. To this end we develop a semi-analytical model for computing planetary systems formation based on the core instability model for the gas accretion of the embryos and the oligarchic growth regime for the accretion of the solid cores. With this model we explore not only different initial discs profiles motivated by similarity solutions for viscous accretion discs, but we also consider different initial conditions to generate a variety of planetary systems assuming a large range of discs masses and sizes according to the last results in protoplanetary discs observations. We form a large population of planetary systems in order to explore the effects in the formation of assuming different discs and also the effects of type I and II regimes of planetary migration, which were found to play fundamental role in reproducing the distribution of observed exoplanets. Our results show that the observed population of exoplanets and the giant planets in the Solar System are well represented when considering a surface density profile with a power law in the inner part characterized by an exponent of -1, which represents a softer profile when compared with the case most similar to the MMSN model case., Comment: 14 pages, 12 figures, MNRAS, 412, 2113

Published
2010
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76. Cardiovascular Statistics – Brazil 2023

Author

Oliveira, Gláucia Maria Moraes de, primary, Brant, Luisa Campos Caldeira, additional, Polanczyk, Carisi Anne, additional, Malta, Deborah Carvalho, additional, Biolo, Andreia, additional, Nascimento, Bruno Ramos, additional, Souza, Maria de Fatima Marinho de, additional, Lorenzo, Andrea Rocha De, additional, Fagundes Júnior, Antonio Aurélio de Paiva, additional, Schaan, Beatriz D., additional, Silva, Christina Grüne de Souza e, additional, Castilho, Fábio Morato de, additional, Cesena, Fernando Henpin Yue, additional, Soares, Gabriel Porto, additional, Xavier Junior, Gesner Francisco, additional, Barreto-Filho, Jose Augusto Soares, additional, Passaglia, Luiz Guilherme, additional, Pinto-Filho, Marcelo Martins, additional, Machline-Carrion, M. Julia, additional, Bittencourt, Marcio Sommer, additional, Pontes Neto, Octavio M., additional, Villela, Paolo Blanco, additional, Teixeira, Renato Azeredo, additional, Stein, Ricardo, additional, Sampaio, Roney Orismar, additional, Gaziano, Thomaz A., additional, Perel, Pablo, additional, Roth, Gregory A., additional, and Ribeiro, Antonio Luiz Pinho, additional

Published
2023
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83. Encuesta sobre la formación de postgrado en la Confederación Americana de Urología: opiniones y realidades

Author

Abad, Jaime, Arley, Andrés, Arriaga, Hugo R., Beckford, Cleveland, Borgen, Jose L., Bueso, Gustavo, Cano, Luis F., Castillo, Octavio, Castillo, Pedro, Cornejo, Francisco, Corrales, Juan G., Costa, Miguel, Cózar, Jose M., de la Concepción, Octavio M., Figueirido, Arnaldo, Lafos, Norberto, Lobo, Luis A., López-Secchi, Gerardo, Martínez, Odir G., Nardozza, Archimedes, X, Alberto Páez, Pazos, Alberto J., Plata, Mauricio, Portillo, Carlos R., Salvador, Denis, Serrano, Eduardo A., Suero, Federico, Torres, Jesús, Torrico, Marcelo, Angulo, J.C., Dávila, H., and Vela, R.

Published
2017
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87. Elevated neutrophil-lymphocyte ratio is associated with high rates of ICU mortality, length of stay, and invasive mechanical ventilation in critically ill patients with COVID-19: NRL and severe COVID-19.

Author

Santos, Heitor O., Delpino, Felipe M., Veloso, Octavio M., Freire, Juliana M. R., Gomes, Erlaine S. N., and Pereira, Cristina G. M.

Abstract

Neutrophil and lymphocyte ratio (NLR) has emerged as a complementary marker in intensive care. This study aimed to associate high NLR values with mortality as the primary outcome, and length of stay and need for invasive mechanical ventilation as secondary outcomes, in critically ill patients with COVID-19. A cross-sectional study encompassing 189 critically ill patients with COVID-19 was performed. The receiver operating characteristic curve was used to identify the best NLR cutoff value for ICU mortality (≥ 10.6). An NLR ≥ 10.6, compared with an NLR < 10.6, was associated with higher odds of ICU mortality (odds ratio [OR], 2.77; 95% confidence interval [CI], 1.24–6.18), ICU length of stay ≥ 14 days (OR, 3.56; 95% CI, 1.01–12.5), and need for invasive mechanical ventilation (OR, 5.39; 95% CI, 1.96–14.81) in the fully adjusted model (age, sex, kidney dysfunction, diabetes, obesity, hypertension, deep vein thrombosis, antibiotics, anticoagulants, antivirals, corticoids, neuromuscular blockers, and vasoactive drugs). In conclusion, elevated NLR is associated with high rates of mortality, length of stay, and need for invasive mechanical ventilation in critically ill patients with COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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88. Abstract 16954: Effect of a Multifaceted Quality Improvement Intervention on the Prescription of Cardiovascular Prevention Treatments in Patients With Coronary Artery Disease Insights From the Bridge Cardiovascular Prevention Cluster Randomized Trial

Author

Machline Carrion, M. Julia, Soares, Rafael M, Penna Guimaraes, Helio P, Nakagawa, Renato H, Damiani, Lucas P, Fonseca, Francisco A, Izar, Maria C, Pontes-neto, Octavio M, Amodeo, Celso, Barros, Pedro G, Stein, Airton T, Piegas, Leopoldo S, Lopes, Renato D, and Berwanger, Otavio B

Published
2020
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90. White Matter Hyperintensities and Poststroke Apathy: A Fully Automated MRI Segmentation Study

Author

Rui Kleber Martins-Filho, Guilherme Rodrigues, Raul Ferreira da Costa, Rodrigo de Souza Castro, Maria Clara Zanon Zotin, Millene R. Camilo, and Octavio M. Pontes-Neto

Subjects
Neurology, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract

Introduction: Poststroke apathy (PSA) is a common neuropsychiatric disorder that may affect up to 30% of stroke patients. Despite the difficulties of investigating this condition (overlapping with depression, heterogeneity of diagnostic criteria, a small number of studies), some recent diffusion tensor imaging studies have suggested that widespread microstructural white matter (WM) disruption plays a key role in the development of PSA. Therefore, we intended to investigate this hypothesis by evaluating the relationship between WM hyperintensities (WMH) and apathy in patients with cerebrovascular disease. Methods: We studied patients with apathy (n = 7), depression (n = 13), comorbid apathy and depression (n = 13), and controls (n = 20), and we investigated the variables associated with the volume of WMH measured by an automated brain MRI segmentation software. Results: The overall prevalence of PSA was 37.7% (pure and comorbid). Patients with apathy presented a higher volume of WMH in comparison to controls. Mini-Mental State Examination (MMSE), NPI-A, and the number of cerebral microbleeds were the only variables associated with WMH. Conversely, NPI-D did not correlate to WMH. Discussion/Conclusion: This is an exploratory study that supports the view of PSA as a distinct syndrome from PSD mediated mainly by diffuse white matter hyperintensities, which suggests that WM disruption is an important pathway to the development of apathy in stroke patients.

Published
2022
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93. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author

Ma, Lu, primary, Hu, Xin, additional, Song, Lili, additional, Chen, Xiaoying, additional, Ouyang, Menglu, additional, Billot, Laurent, additional, Li, Qiang, additional, Malavera, Alejandra, additional, Li, Xi, additional, Muñoz-Venturelli, Paula, additional, de Silva, Asita, additional, Thang, Nguyen Huy, additional, Wahab, Kolawole W, additional, Pandian, Jeyaraj D, additional, Wasay, Mohammad, additional, Pontes-Neto, Octavio M, additional, Abanto, Carlos, additional, Arauz, Antonio, additional, Shi, Haiping, additional, Tang, Guanghai, additional, Zhu, Sheng, additional, She, Xiaochun, additional, Liu, Leibo, additional, Sakamoto, Yuki, additional, You, Shoujiang, additional, Han, Qiao, additional, Crutzen, Bernard, additional, Cheung, Emily, additional, Li, Yunke, additional, Wang, Xia, additional, Chen, Chen, additional, Liu, Feifeng, additional, Zhao, Yang, additional, Li, Hao, additional, Liu, Yi, additional, Jiang, Yan, additional, Chen, Lei, additional, Wu, Bo, additional, Liu, Ming, additional, Xu, Jianguo, additional, You, Chao, additional, Anderson, Craig S, additional, Robinson, Thompson, additional, Miranda, J. Jaime, additional, Anderson, Craig S., additional, Parry-Jones, Adrian, additional, Sprigg, Nikola, additional, Durrans, Sophie, additional, Harris, Caroline, additional, Bamford, Ann, additional, Smith, Olivia, additional, Herbert, Robert, additional, Chen, Christopher, additional, Whiteley, William, additional, Hu, Rong, additional, Mysore, Jayanthi, additional, Zhang, Yao, additional, Jan, Stephen, additional, Liu, Hueiming, additional, Sun, Lingli, additional, Chu, Honglin, additional, Anjum, Anila, additional, Gonzalez Mc Cawley, Francisca, additional, Del Rio, Alejandra, additional, Rimoli, Bruna, additional, Cerantola, Rodrigo, additional, Jeevarajah, Thanushanthan, additional, Kannangara, Madhushani, additional, Joseph, Andrene, additional, Nanayakkara, Chamath, additional, Zhang, Chunmiao, additional, Yang, Zhao, additional, Li, Brook, additional, Meng, Zhuo, additional, Ning, Yi, additional, Dong, Le, additional, Armenis, Manuela, additional, Lim, Joyce, additional, Monaghan, Helen, additional, Ma, Lu, additional, Luo, Rui, additional, Cheng, Guojuan, additional, Dong, Yilin, additional, Liu, Ziqin, additional, Wang, Shuihong, additional, Zhang, Ying, additional, Cheng, Jipeng, additional, Shi, Hui, additional, Li, Wenjing, additional, Mou, Langming, additional, Yi, Ping, additional, Chen, Xue, additional, Weerawardena, Shalomi, additional, Ellawala, Poornima, additional, Ranasinghe, Enalee, additional, Rodrigo, Chrishmi, additional, Wahab, Kolawala, additional, Adeniyi, Sunday, additional, Pandian, Jeyaraj, additional, Khanna, Megha, additional, Muñoz Venturelli, Paula, additional, González, Francisca, additional, Urrutia Goldsack, Francisca, additional, Begum, Dilshad, additional, Pontes-Neto, Octavio, additional, Camilo, Millene, additional, Dias, Francisco, additional, Vincenzi, Octavio, additional, Moro, Carla, additional, Santos, Renata, additional, Texeira, Nara, additional, Longo, Alexandre, additional, Liberato, Rafaela, additional, Martins, Sheila, additional, Pille, Arthur, additional, Chwal, Bruna, additional, Silva, Isabel, additional, Titton, Natacha, additional, Weiss, Gustavo, additional, Mora, Daissy, additional, Ouriques, Magda, additional, Carbonera, Leonardo, additional, Bazan, Rodrigo, additional, Modolo, Gabriel, additional, Winckler, Fernanda, additional, Miranda, Luana, additional, Souza, Juli, additional, Rojo, Alexis, additional, Uslar, Wilhelm, additional, Medel, Lorena, additional, Lopez, Javiera, additional, Herrero, Diego, additional, Lavados, Pablo, additional, Vargas Latorre, Barbara, additional, Conejan, Nathalie, additional, Esparza, Tomas, additional, Sotomayor, Patricio, additional, Wenger, Denisse, additional, Gigoux, Juan Pablo, additional, Letelier, Aldo, additional, Acevedo, Lilian, additional, Moya, Vivianne, additional, Figueroa, Cristian, additional, Vallejos, Nicol, additional, Guerrero, Rodrigo, additional, Velasquez, Mauricio, additional, Vallejos, Jose, additional, Pallauta, Kimerly, additional, Santibanez, Tamara, additional, Queirolo, Angelo, additional, Lobos, Andrea, additional, Jiang, Yongming, additional, Li, Weimin, additional, Huang, Wei, additional, Luo, Ke, additional, Liu, Gangying, additional, Yang, Guang, additional, Jiang, Hongtao, additional, Zhang, Xu, additional, Jing, Hongyan, additional, Pu, Bo, additional, Lv, Dong, additional, Kang, Hui, additional, Hu, Qiuping, additional, Jiang, Xiaoming, additional, Chen, Yanli, additional, Yang, Shenghua, additional, He, Jianjun, additional, Li, Zongping, additional, Cheng, Gang, additional, Huang, Hailin, additional, Wang, Xiaoyi, additional, Lin, Jianqiong, additional, Chen, Minhui, additional, Yang, Chenghao, additional, Ding, Hao, additional, Deng, Yunliang, additional, Luo, Fei, additional, Zhang, Rongjun, additional, Wang, Xiaofeng, additional, Zhang, Hongbing, additional, Yang, Xiaoliang, additional, Zhang, Yang, additional, Yang, Chengyi, additional, He, Yu, additional, Liu, Feng, additional, Wang, Rongjie, additional, Zhang, Yuhui, additional, Xin, Xiaodong, additional, Feng, Bin, additional, Hao, Wanru, additional, Song, Chang, additional, Guo, Yun, additional, Jiang, Dehua, additional, Chen, Jie, additional, Tang, Changtong, additional, Zhu, Hongliang, additional, Li, Xin, additional, Cui, Jin, additional, Xu, Haidong, additional, Li, Boyang, additional, Tang, Fusheng, additional, Li, Yuanbin, additional, Gao, Min, additional, Yang, Bo, additional, Xu, Xuejun, additional, Deng, Bing, additional, Zheng, Yi, additional, Ge, Yuanhong, additional, Chen, Keyu, additional, Liu, Yang, additional, Li, Xinshen, additional, Zhong, Tingting, additional, Xu, Jianfeng, additional, Zhang, Hai, additional, Wang, Jiyue, additional, Zhu, Jianxin, additional, Sun, Hanyu, additional, Yu, Fuhua, additional, Zhang, Xueguang, additional, Zhang, Mingsen, additional, Wang, Bin, additional, Ma, Yiming, additional, Jiang, Donglin, additional, Zhou, Jun, additional, Liu, Cong, additional, Nie, Wenhong, additional, Li, Mingguo, additional, Tian, Tao, additional, Li, Yong, additional, He, Mingfang, additional, Tu, Xiaolong, additional, Wu, Zhengjun, additional, Liu, Hong, additional, Zhong, Dongsheng, additional, Jiang, Rongcai, additional, Sun, Jian, additional, Tian, Ye, additional, Wei, Yingsheng, additional, An, Shuo, additional, Wei, Pingbo, additional, Luo, Le, additional, Lin, Bin, additional, Liu, Gang, additional, Wen, Yan, additional, Cai, Qiang, additional, Chen, Qianxue, additional, Lei, Pan, additional, Li, Zhiyang, additional, Zhang, Meifang, additional, He, Jiaquan, additional, Chen, Yan, additional, Liu, Jun, additional, Liu, Xinghai, additional, Li, Junyan, additional, Chen, Min, additional, Wang, Jing, additional, Zhou, Bingzhi, additional, Ye, Baichun, additional, Zhang, Jiancheng, additional, Zhang, Manyuan, additional, Pan, Xuming, additional, Yu, Xiaoxiang, additional, Xu, Jian, additional, Xiao, Qingbao, additional, Wang, Yuefei, additional, Tao, Liang, additional, Shi, Lin, additional, Zheng, Niandong, additional, You, Guoliang, additional, Lei, Bo, additional, Chen, Shu, additional, Wu, Honggang, additional, Hu, Jin, additional, Zhao, Jianlan, additional, Yu, Jian, additional, Yuan, Qiang, additional, Du, Zhuoying, additional, Tang, Xielin, additional, Li, Qianke, additional, Liu, Shenghua, additional, Yang, Feilong, additional, Xiao, Kui, additional, Luo, Chao, additional, Wang, Guang, additional, Che, Xudong, additional, Teng, Zhipeng, additional, Wan, Wenwu, additional, Li, Jun, additional, Liu, Yu, additional, Fan, Mingbo, additional, Zhang, Tao, additional, Cai, Lun, additional, Ma, Yuan, additional, Ma, Zhifeng, additional, Li, Bin, additional, He, Linlin, additional, Li, Jinghui, additional, Zhang, Weibing, additional, Zhang, Shuxin, additional, Zhang, Hongzhen, additional, Dai, Yingguang, additional, Lei, Jun, additional, Mao, Lei, additional, Huang, Yiyang, additional, Zhou, Zhi, additional, Chen, Ping, additional, Chen, Fang, additional, Wei, Pan, additional, Li, Tiangui, additional, Chen, Honglin, additional, Zeng, Mengfei, additional, Mou, Kejie, additional, Xue, Jun, additional, Jiang, Yong, additional, Tang, Xiaoping, additional, Chen, Tao, additional, Zhang, Yalan, additional, Xu, Yanbing, additional, Gu, Yuchen, additional, Zhao, Yujun, additional, Yang, Bin, additional, Kuai, Peng, additional, Wang, Xi, additional, Yang, Yuwang, additional, Hu, Xueling, additional, Zhang, Huitian, additional, Yang, Yintao, additional, Wang, Weifeng, additional, Zhang, Junyi, additional, Cheng, Wei, additional, Zhang, Xiaoxue, additional, Ma, Xiaowen, additional, He, Qin, additional, Zhang, Li, additional, Gao, Rong, additional, Liu, Huixiang, additional, Ye, Jingwei, additional, Xu, Ping, additional, Wu, Xin, additional, Yuan, Yuan, additional, Zou, Peng, additional, Zhang, Zhen, additional, Cheng, Jiyong, additional, Zhou, Zhangming, additional, Zeng, Yijun, additional, Liang, Zhang, additional, Du, Deming, additional, Yu, Shui, additional, Cao, Yongjun, additional, Xu, Jiaping, additional, Huang, Zhichao, additional, Chen, Dongqin, additional, Xiao, Wenfeng, additional, Zhu, Li, additional, Yuan, Miao, additional, Wang, Yuhai, additional, Shi, Dongliang, additional, Hu, Xu, additional, Xiang, Dingchao, additional, Shi, Like, additional, Wang, Hongqin, additional, Yang, Liu, additional, Miao, Wang, additional, Hu, Yiyi, additional, Zhao, Yuchun, additional, Hu, Xi, additional, Zhou, Weiduo, additional, Sun, Chao, additional, Tang, Dong, additional, Yao, Kun, additional, You, Jin, additional, Chen, Shishi, additional, Yao, Jianmin, additional, Li, Huanmei, additional, Liu, Jinmei, additional, Bai, Ailin, additional, Yi, Yong, additional, Deng, Qingshan, additional, Luo, Peng, additional, Wang, Han, additional, Jiang, Jingcheng, additional, Yang, Qingwei, additional, He, Shunpo, additional, Wang, Jun, additional, Chen, Yu, additional, He, Hua, additional, Deng, Yuyang, additional, Cao, Zhikai, additional, Yi, Xuxia, additional, Luo, Jinbiao, additional, Luo, Shuang, additional, Gong, Min, additional, Liu, Li, additional, Gao, Xuejun, additional, Liu, Jia, additional, Wu, Li'e, additional, Zhang, Jia, additional, Sun, Hongying, additional, Li, Xinhui, additional, Jia, Lu, additional, Wu, Jianbing, additional, Zhang, Jie, additional, Zhang, Huajun, additional, Du, Chunfu, additional, Li, Shun, additional, Yang, Xiaobin, additional, He, Jie, additional, Liao, Lei, additional, Zhou, Gezhi, additional, Dong, Wentao, additional, Chen, Yunxiang, additional, Lin, Xiaofeng, additional, Shui, Xujian, additional, Zhang, Peng, additional, Zhao, Yuan, additional, Yang, Hongli, additional, Zhao, Wenbin, additional, Zhang, Xiaoyi, additional, Chen, Jincao, additional, Wu, Qian, additional, Dai, Xuan, additional, Tang, Baogui, additional, Wang, Yinjuan, additional, Liu, Tao, additional, Zhang, Haixia, additional, Duan, Faliang, additional, Luo, Ming, additional, Jiao, Qingfang, additional, Lei, Guoliang, additional, Wang, Dong, additional, Song, Chunwang, additional, Tan, Haopeng, additional, Ye, Feng, additional, Qin, Xinghu, additional, Liang, Xiaolong, additional, Liu, Junling, additional, Yang, Lang, additional, Yang, Jie, additional, Lin, Yapeng, additional, Yang, Qian, additional, Ma, Xuntai, additional, Qi, Yinkuang, additional, Pan, Baogen, additional, Jiang, Caixia, additional, Ye, Zhanying, additional, Dong, Ce, additional, Yue, Xiongfei, additional, Yang, Xiaopeng, additional, Maimaitiyiming, Tuoheti, additional, Dong, Jun, additional, Wu, Yonggang, additional, Gao, Feng, additional, Zhao, Deqiang, additional, Zhang, Xinghai, additional, Wang, PengJun, additional, Jiang, Hongbo, additional, Li, Jianping, additional, Zhang, Wei, additional, Chen, Jing, additional, Tong, Haibo, additional, Wang, Yonghong, additional, Qiao, Kaipeng, additional, Guo, Fuyou, additional, Zhang, Mingchu, additional, Hu, Yan, additional, Feng, Mengzhao, additional, Song, Dengpan, additional, Zuo, Yi, additional, Chen, Shangjun, additional, Qian, Chao, additional, Li, Baoming, additional, Ma, Jingku, additional, Zhang, Sunfu, additional, Kong, Bin, additional, Dong, Xingyu, additional, Fang, Sheng, additional, Lu, Bin, additional, Li, Yang, additional, Yang, Yongling, additional, Yu, Hong, additional, Sun, Huaiyu, additional, Wang, Yue, additional, Wang, Weimin, additional, Li, Tong, additional, Li, Shengli, additional, Xu, Zhiming, additional, Wang, Yongyi, additional, Dong, Qiang, additional, Tang, Yuping, additional, Chu, Heling, additional, Lu, Ying, additional, Wang, Zhong, additional, Sun, Xiaoou, additional, Zhao, Jianhua, additional, Yang, Shuaifeng, additional, Qian, Xiying, additional, Saroja, Aralikatte Onkarappa, additional, Naik k, Ravishankar, additional, Chindhi, Sandip, additional, Pampaniya, Nakul, additional, Amaresh, Kurubara, additional, Iype, Thomas, additional, R, Dileep, additional, Rajan, Reeja, additional, Panicker, Praveen, additional, Das, Rupjyoti, additional, Choudhury, Nupur, additional, Gohain, Pankaja, additional, Webster, Jemin, additional, Pakma, Biyol, additional, Sangi, Lalbiak, additional, Sebastian, Ivy, additional, Aggrawal, Gaurav, additional, Raj, Komal, additional, Rajoura, Deepankshi, additional, Singh, Sulena, additional, Aggrawal, Varun, additional, Narang, Amit, additional, Cano-Nigenda, Vanesa, additional, López-Mena, Diego, additional, Valdez-Ruvalcaba, Héctor, additional, Toledo-Treviño, Roberto, additional, Obiako, Reginald, additional, Abubakar, Sani, additional, Emeka, Oguike, additional, Olayemi, Balogun, additional, Lois, Melika, additional, Philip, Ibinaiye, additional, Comfort O, Olurishe, additional, Okubadejo, Njideka, additional, Agabi, Osigwe, additional, Ojo, Oluwadamilola, additional, Wahab, Kolawole, additional, Bello, Abiodun, additional, Ibukun, Oyinloye, additional, Sanayaolu, Olufemi, additional, Jimoh, Abdulraheem, additional, Waheed, Shahid, additional, Kamal, Dr.Ayeesha, additional, Shoaib, Raja Farhat, additional, Orooj, Fizza, additional, Majid, Sadaf, additional, Zehra, Taskeen, additional, Khan, Abdus Salam, additional, Shanker, Ravi, additional, Syed, Nadir Ali, additional, Ahmad, Nashwa, additional, Valencia, Ana, additional, Barrientos, Danny, additional, Ramirez, Jorge, additional, Calle, Pilar, additional, Palliyeguruge, Dilum, additional, Muthucumarana, Sumudu, additional, Ratnayaka, Shiroma, additional, Ganihiarachchi, Dilhara, additional, Bandaranayake, Arundathi, additional, Somaratne, S.D.B, additional, Narayana, Saumya, additional, Gallage, Sithara, additional, Senanayake, Bimsara, additional, Samarasiri, Udari, additional, Luke, Dunya, additional, Sivapathasundaram, Mythily, additional, Sahadevan, Vithoosan, additional, Rasmi, Amani, additional, Deshaka, Yuran, additional, Fernando, Nilukshi, additional, Munasinghe, Aruna, additional, Rathnapriya, Kapilanga, additional, Nissanka, A.S, additional, Karunathilake, Kanchana, additional, Gayan, Isuru, additional, Wijenayake, Kaminda, additional, Gunasekara, Hasitha, additional, Vidyarathne, Jagath, additional, Keshavaraj, Ajantha, additional, Janarthanan, Kanagasabapathy, additional, Gerald Jeevathasan, Arhivalaky, additional, Sivamainthan, Sivaram, additional, John Priyanth, Mathyamuthan, additional, John Priyanth, Abirami, additional, Rajendiran, Thambippillai, additional, Alwis, Sanjeewa, additional, Gunasekare, Nushara, additional, Liyanarachchi, Vasundara, additional, Dissanayake, Athula, additional, Uluwattage, Wimalasiri Mewa, additional, Ratnayake, Gimhani, additional, Rajinee, Charika, additional, Jayawardana, Sakura, additional, Peiris, Janaka, additional, Wicramasinghe, Ranjith, additional, Fernando, Chamila, additional, Abbas, Jessie, additional, Withanage, Nethmini, additional, Bandara, Makaranda, additional, Mai, Duy Ton, additional, Nguyen, Van Chi, additional, Dao, Viet Phuong, additional, Vuong, Xuan Trung, additional, Nguyen, Tien Dung, additional, Dinh, Trung Hieu, additional, Phan, Ha Quan, additional, Bui, Quoc Viet, additional, Phung, Dinh Tho, additional, Pham, Quang Tho, additional, Pham, Dinh Dai, additional, Do, Duc Thuan, additional, Dang, Phuc Duc, additional, Dang, Minh Duc, additional, Nguyen, Dang Hai, additional, Nguyen, Thi Phuong Nga, additional, Nguyen, Quoc Huy, additional, Pham, Quoc Dai, additional, Chau, Quoc Vinh, additional, Tai, Vinh Thy Van, additional, Le, Tran Vinh, additional, Le, Cong Tri, additional, Tran, Ha Mai Khuong, additional, Nguyen, Huu Khanh, additional, Ngyen, Hoang Minh Thao, additional, Vo, Duc Chien, additional, Nguyen, Thai My Phuong, additional, Tran, Trung Thanh, additional, Vo, Thi Hanh Vi, additional, Cao, Hao Nhien, additional, Nguyen, Ba Thang, additional, Le, Thi Ngoc Suong, additional, La, Thien Duc, additional, Pham, Chi Duc, additional, and Thai, Huy, additional

Published
2023
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95. Analysis of 565 thrombectomies for anterior circulation stroke: A Brazilian registry

Author

Luis Henrique de Castro-Afonso, Thiago Giansante Abud, Lucas Moretti Monsignore, Guilherme Seizem Nakiri, Francisco Antunes Dias, Octavio M. Pontes-Neto, Vitor Rodrigues Fornazari, and Daniel Giansante Abud

Subjects
medicine.medical_specialty, Large vessel, law.invention, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Humans, 030212 general & internal medicine, Registries, Stroke, Acute ischemic stroke, Stent retriever, Acute stroke, Retrospective Studies, Thrombectomy, business.industry, Original Articles, medicine.disease, Mechanical thrombectomy, Treatment Outcome, Cardiology, Stents, business, 030217 neurology & neurosurgery, Brazil, Large vessel occlusion
Abstract

Introduction The benefits of mechanical thrombectomy in the treatment of patients with acute stroke due to large vessel occlusions (LVOs) have been extensively demonstrated by randomized trials and registries in developed countries. However, data on thrombectomy outside controlled trials are scarce in developing countries. The aim of this study was to assess the safety and efficacy, and to investigate the predictors for good and poor outcomes of thrombectomy for treatment of AIS due to anterior circulation LVOs in Brazil. Materials and Methods This was a single center registry of thrombectomy in the treatment of stroke caused by anterior circulation LVOs. Between 2011 and 2019, a total of 565 patients were included. Results the mean baseline NIHSS score on admission was 17.2. The average baseline ASPECTS was 8, and 91.0% of patients scored ≥6. Half of the patients received intravenous thrombolysis. The mean time from symptom onset to arterial puncture was 296.4 minutes. The mean procedure time was 61.4 minutes. The rates of the main outcomes were recanalization (TICI 2b-3) 85.6%, symptomatic intracranial hemorrhage (sICH) 8,1%, good clinical outcome (mRS=0-2) 43,5%, and mortality 22.1% at three months. Conclusions This study demonstrates the efficacy and safety of mechanical thrombectomy for treatment of patients with AIS of the anterior circulation in real-life conditions under limited facilities and resources. The results of the present study were relatively similar to those of large trials and population registers of developed countries.

Published
2023

96. Subtle white matter intensity changes on FLAIR imaging in patients with ischemic stroke

Author

Pedro Cougo, Heber Colares, João Gabriel Farinhas, Mariana Hämmerle, Pedro Neves, Raquel Bezerra, Alex Balduíno, Ona Wu, and Octavio M. Pontes-Neto

Abstract

BackgroundThere is increasing evidence from pathology and neuroimaging suggesting that the structural abnormalities which characterize leukoaraiosis are present within regions of normal-appearing white matter. In this study, we aimed to verify whether signal intensity on FLAIR imaging in normal-appearing white matter is related to the leukoaraiosis burden.MethodsWe performed a cross-sectional study of adult patients admitted with a diagnosis of acute ischemic stroke or transient ischemic attack. Leukoaraiosis was segmented using a semi-automated method involving manual outlining and signal thresholding. White matter regions were segmented based on the probabilistic tissue maps from the International Consortium for Brain Mapping 152 atlas. Also, white matter was further segmented based on voxel-distance from leukoaraiosis borders. Normalized mean FLAIR signal intensity on normal-appearing white matter (NAWMM) was used as a dependent variable in univariate and multivariate statistical analysis, and leukoaraiosis volume quartiles (LKAV) and clinical data as independent variables.ResultsOne-hundred consecutive patients were selected for analysis (53% female, mean age 68 years). NAWMMwas higher in the vicinity of leukoaraiosis and progressively lower at increasing distances from leukoaraiosis. NAWMMwas independently associated with leukoaraiosis volume. In voxels in the vicinity of leukoaraiosis borders, there was a linear association between LKAVand NAWMM(B=0.03;PMamong patients in the second and third quartiles, and lower in the first and fourth quartiles (B=-0.21 for the second order term;PM.ConclusionsOur results show that normal-appearing white matter exhibits subtle signal intensity changes that are related to leukoaraiosis burden. The neuroimaging signature of these subtle changes suggests that they might not be a milder form of leukoaraiosis, but rather rather reflect widespread etiopathogenic processes underlying small-vessel disease and thus, leukoaraiosis development.

Published
2023
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97. The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Author

Lu Ma, Xin Hu, Lili Song, Xiaoying Chen, Menglu Ouyang, Laurent Billot, Qiang Li, Alejandra Malavera, Xi Li, Paula Muñoz-Venturelli, Asita de Silva, Nguyen Huy Thang, Kolawole W Wahab, Jeyaraj D Pandian, Mohammad Wasay, Octavio M Pontes-Neto, Carlos Abanto, Antonio Arauz, Haiping Shi, Guanghai Tang, Sheng Zhu, Xiaochun She, Leibo Liu, Yuki Sakamoto, Shoujiang You, Qiao Han, Bernard Crutzen, Emily Cheung, Yunke Li, Xia Wang, Chen Chen, Feifeng Liu, Yang Zhao, Hao Li, Yi Liu, Yan Jiang, Lei Chen, Bo Wu, Ming Liu, Jianguo Xu, Chao You, Craig S Anderson, Thompson Robinson, J. Jaime Miranda, Craig S. Anderson, Adrian Parry-Jones, Nikola Sprigg, Sophie Durrans, Caroline Harris, Ann Bamford, Olivia Smith, Robert Herbert, Christopher Chen, William Whiteley, Rong Hu, Jayanthi Mysore, Yao Zhang, Stephen Jan, Hueiming Liu, Lingli Sun, Honglin Chu, Anila Anjum, Francisca Gonzalez Mc Cawley, Alejandra Del Rio, Bruna Rimoli, Rodrigo Cerantola, Thanushanthan Jeevarajah, Madhushani Kannangara, Andrene Joseph, Chamath Nanayakkara, Chunmiao Zhang, Zhao Yang, Brook Li, Zhuo Meng, Yi Ning, Le Dong, Manuela Armenis, Joyce Lim, Helen Monaghan, Rui Luo, Guojuan Cheng, Yilin Dong, Ziqin Liu, Shuihong Wang, Ying Zhang, Jipeng Cheng, Hui Shi, Wenjing Li, Langming Mou, Ping Yi, Xue Chen, Shalomi Weerawardena, Poornima Ellawala, Enalee Ranasinghe, Chrishmi Rodrigo, Kolawala Wahab, Sunday Adeniyi, Jeyaraj Pandian, Megha Khanna, Paula Muñoz Venturelli, Francisca González, Francisca Urrutia Goldsack, Dilshad Begum, Octavio Pontes-Neto, Millene Camilo, Francisco Dias, Octavio Vincenzi, Carla Moro, Renata Santos, Nara Texeira, Alexandre Longo, Rafaela Liberato, Sheila Martins, Arthur Pille, Bruna Chwal, Isabel Silva, Natacha Titton, Gustavo Weiss, Daissy Mora, Magda Ouriques, Leonardo Carbonera, Rodrigo Bazan, Gabriel Modolo, Fernanda Winckler, Luana Miranda, Juli Souza, Alexis Rojo, Wilhelm Uslar, Lorena Medel, Javiera Lopez, Diego Herrero, Pablo Lavados, Barbara Vargas Latorre, Nathalie Conejan, Tomas Esparza, Patricio Sotomayor, Denisse Wenger, Juan Pablo Gigoux, Aldo Letelier, Lilian Acevedo, Vivianne Moya, Cristian Figueroa, Nicol Vallejos, Rodrigo Guerrero, Mauricio Velasquez, Jose Vallejos, Kimerly Pallauta, Tamara Santibanez, Angelo Queirolo, Andrea Lobos, Yongming Jiang, Weimin Li, Wei Huang, Ke Luo, Gangying Liu, Guang Yang, Hongtao Jiang, Xu Zhang, Hongyan Jing, Bo Pu, Dong Lv, Hui Kang, Qiuping Hu, Xiaoming Jiang, Yanli Chen, Shenghua Yang, Jianjun He, Zongping Li, Gang Cheng, Hailin Huang, Xiaoyi Wang, Jianqiong Lin, Minhui Chen, Chenghao Yang, Hao Ding, Yunliang Deng, Fei Luo, Rongjun Zhang, Xiaofeng Wang, Hongbing Zhang, Xiaoliang Yang, Yang Zhang, Chengyi Yang, Yu He, Feng Liu, Rongjie Wang, Yuhui Zhang, Xiaodong Xin, Bin Feng, Wanru Hao, Chang Song, Yun Guo, Dehua Jiang, Jie Chen, Changtong Tang, Hongliang Zhu, Xin Li, Jin Cui, Haidong Xu, Boyang Li, Fusheng Tang, Yuanbin Li, Min Gao, Bo Yang, Xuejun Xu, Bing Deng, Yi Zheng, Yuanhong Ge, Keyu Chen, Yang Liu, Xinshen Li, Tingting Zhong, Jianfeng Xu, Hai Zhang, Jiyue Wang, Jianxin Zhu, Hanyu Sun, Fuhua Yu, Xueguang Zhang, Mingsen Zhang, Bin Wang, Yiming Ma, Donglin Jiang, Jun Zhou, Cong Liu, Wenhong Nie, Mingguo Li, Tao Tian, Yong Li, Mingfang He, Xiaolong Tu, Zhengjun Wu, Hong Liu, Dongsheng Zhong, Rongcai Jiang, Jian Sun, Ye Tian, Yingsheng Wei, Shuo An, Pingbo Wei, Le Luo, Bin Lin, Gang Liu, Yan Wen, Qiang Cai, Qianxue Chen, Pan Lei, Zhiyang Li, Meifang Zhang, Jiaquan He, Yan Chen, Jun Liu, Xinghai Liu, Junyan Li, Min Chen, Jing Wang, Bingzhi Zhou, Baichun Ye, Jiancheng Zhang, Manyuan Zhang, Xuming Pan, Xiaoxiang Yu, Jian Xu, Qingbao Xiao, Yuefei Wang, Liang Tao, Lin Shi, Niandong Zheng, Guoliang You, Bo Lei, Shu Chen, Honggang Wu, Jin Hu, Jianlan Zhao, Jian Yu, Qiang Yuan, Zhuoying Du, Xielin Tang, Qianke Li, Shenghua Liu, Feilong Yang, Kui Xiao, Chao Luo, Guang Wang, Xudong Che, Zhipeng Teng, Wenwu Wan, Jun Li, Yu Liu, Mingbo Fan, Tao Zhang, Lun Cai, Yuan Ma, Zhifeng Ma, Bin Li, Linlin He, Jinghui Li, Weibing Zhang, Shuxin Zhang, Hongzhen Zhang, Yingguang Dai, Jun Lei, Lei Mao, Yiyang Huang, Zhi Zhou, Ping Chen, Fang Chen, Pan Wei, Tiangui Li, Honglin Chen, Mengfei Zeng, Kejie Mou, Jun Xue, Yong Jiang, Xiaoping Tang, Tao Chen, Yalan Zhang, Yanbing Xu, Yuchen Gu, Yujun Zhao, Bin Yang, Peng Kuai, Xi Wang, Yuwang Yang, Xueling Hu, Huitian Zhang, Yintao Yang, Weifeng Wang, Junyi Zhang, Wei Cheng, Xiaoxue Zhang, Xiaowen Ma, Qin He, Li Zhang, Rong Gao, Huixiang Liu, Jingwei Ye, Ping Xu, Xin Wu, Yuan Yuan, Peng Zou, Zhen Zhang, Jiyong Cheng, Zhangming Zhou, Yijun Zeng, Zhang Liang, Deming Du, Shui Yu, Yongjun Cao, Jiaping Xu, Zhichao Huang, Dongqin Chen, Wenfeng Xiao, Li Zhu, Miao Yuan, Yuhai Wang, Dongliang Shi, Xu Hu, Dingchao Xiang, Like Shi, Hongqin Wang, Liu Yang, Wang Miao, Yiyi Hu, Yuchun Zhao, Xi Hu, Weiduo Zhou, Chao Sun, Dong Tang, Kun Yao, Jin You, Shishi Chen, Jianmin Yao, Huanmei Li, Jinmei Liu, Ailin Bai, Yong Yi, Qingshan Deng, Peng Luo, Han Wang, Jingcheng Jiang, Qingwei Yang, Shunpo He, Jun Wang, Yu Chen, Hua He, Yuyang Deng, Zhikai Cao, Xuxia Yi, Jinbiao Luo, Shuang Luo, Min Gong, Li Liu, Xuejun Gao, Jia Liu, Li'e Wu, Jia Zhang, Hongying Sun, Xinhui Li, Lu Jia, Jianbing Wu, Jie Zhang, Huajun Zhang, Chunfu Du, Shun Li, Xiaobin Yang, Jie He, Lei Liao, Gezhi Zhou, Wentao Dong, Yunxiang Chen, Xiaofeng Lin, Xujian Shui, Peng Zhang, Yuan Zhao, Hongli Yang, Wenbin Zhao, Xiaoyi Zhang, Jincao Chen, Qian Wu, Xuan Dai, Baogui Tang, Yinjuan Wang, Tao Liu, Haixia Zhang, Faliang Duan, Ming Luo, Qingfang Jiao, Guoliang Lei, Dong Wang, Chunwang Song, Haopeng Tan, Feng Ye, Xinghu Qin, Xiaolong Liang, Junling Liu, Lang Yang, Jie Yang, Yapeng Lin, Qian Yang, Xuntai Ma, Yinkuang Qi, Baogen Pan, Caixia Jiang, Zhanying Ye, Ce Dong, Xiongfei Yue, Xiaopeng Yang, Tuoheti Maimaitiyiming, Jun Dong, Yonggang Wu, Feng Gao, Deqiang Zhao, Xinghai Zhang, PengJun Wang, Hongbo Jiang, Jianping Li, Wei Zhang, Jing Chen, Haibo Tong, Yonghong Wang, Kaipeng Qiao, Fuyou Guo, Mingchu Zhang, Yan Hu, Mengzhao Feng, Dengpan Song, Yi Zuo, Shangjun Chen, Chao Qian, Baoming Li, Jingku Ma, Sunfu Zhang, Bin Kong, Xingyu Dong, Sheng Fang, Bin Lu, Yang Li, Yongling Yang, Hong Yu, Huaiyu Sun, Yue Wang, Weimin Wang, Tong Li, Shengli Li, Zhiming Xu, Yongyi Wang, Qiang Dong, Yuping Tang, Heling Chu, Ying Lu, Zhong Wang, Xiaoou Sun, Jianhua Zhao, Shuaifeng Yang, Xiying Qian, Aralikatte Onkarappa Saroja, Ravishankar Naik k, Sandip Chindhi, Nakul Pampaniya, Kurubara Amaresh, Thomas Iype, Dileep R, Reeja Rajan, Praveen Panicker, Rupjyoti Das, Nupur Choudhury, Pankaja Gohain, Jemin Webster, Biyol Pakma, Lalbiak Sangi, Ivy Sebastian, Gaurav Aggrawal, Komal Raj, Deepankshi Rajoura, Sulena Singh, Varun Aggrawal, Amit Narang, Vanesa Cano-Nigenda, Diego López-Mena, Héctor Valdez-Ruvalcaba, Roberto Toledo-Treviño, Reginald Obiako, Sani Abubakar, Oguike Emeka, Balogun Olayemi, Melika Lois, Ibinaiye Philip, Olurishe Comfort O, Njideka Okubadejo, Osigwe Agabi, Oluwadamilola Ojo, Kolawole Wahab, Abiodun Bello, Oyinloye Ibukun, Olufemi Sanayaolu, Abdulraheem Jimoh, Shahid Waheed, Dr.Ayeesha Kamal, Raja Farhat Shoaib, Fizza Orooj, Sadaf Majid, Taskeen Zehra, Abdus Salam Khan, Ravi Shanker, Nadir Ali Syed, Nashwa Ahmad, Ana Valencia, Danny Barrientos, Jorge Ramirez, Pilar Calle, Dilum Palliyeguruge, Sumudu Muthucumarana, Shiroma Ratnayaka, Dilhara Ganihiarachchi, Arundathi Bandaranayake, S.D.B Somaratne, Saumya Narayana, Sithara Gallage, Bimsara Senanayake, Udari Samarasiri, Dunya Luke, Mythily Sivapathasundaram, Vithoosan Sahadevan, Amani Rasmi, Yuran Deshaka, Nilukshi Fernando, Aruna Munasinghe, Kapilanga Rathnapriya, A.S Nissanka, Kanchana Karunathilake, Isuru Gayan, Kaminda Wijenayake, Hasitha Gunasekara, Jagath Vidyarathne, Ajantha Keshavaraj, Kanagasabapathy Janarthanan, Arhivalaky Gerald Jeevathasan, Sivaram Sivamainthan, Mathyamuthan John Priyanth, Abirami John Priyanth, Thambippillai Rajendiran, Sanjeewa Alwis, Nushara Gunasekare, Vasundara Liyanarachchi, Athula Dissanayake, Wimalasiri Mewa Uluwattage, Gimhani Ratnayake, Charika Rajinee, Sakura Jayawardana, Janaka Peiris, Ranjith Wicramasinghe, Chamila Fernando, Jessie Abbas, Nethmini Withanage, Makaranda Bandara, Duy Ton Mai, Van Chi Nguyen, Viet Phuong Dao, Xuan Trung Vuong, Tien Dung Nguyen, Trung Hieu Dinh, Ha Quan Phan, Quoc Viet Bui, Dinh Tho Phung, Quang Tho Pham, Dinh Dai Pham, Duc Thuan Do, Phuc Duc Dang, Minh Duc Dang, Dang Hai Nguyen, Thi Phuong Nga Nguyen, Quoc Huy Nguyen, Quoc Dai Pham, Quoc Vinh Chau, Vinh Thy Van Tai, Tran Vinh Le, Cong Tri Le, Ha Mai Khuong Tran, Huu Khanh Nguyen, Hoang Minh Thao Ngyen, Duc Chien Vo, Thai My Phuong Nguyen, Trung Thanh Tran, Thi Hanh Vi Vo, Hao Nhien Cao, Ba Thang Nguyen, Thi Ngoc Suong Le, Thien Duc La, Chi Duc Pham, and Huy Thai

Subjects
General Medicine
Published
2023
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98. Karyotype evolution in Ronderosia grasshoppers (Orthoptera: Acrididae)

Author

Castillo, Elio Rodrigo D., Celeste Scattolini, M., Palacios-Gimenez, Octavio M., Marti, Dardo A., Cabral-De-Mello, Diogo C., Cigliano, Maria M., Castillo, Elio Rodrigo D., Celeste Scattolini, M., Palacios-Gimenez, Octavio M., Marti, Dardo A., Cabral-De-Mello, Diogo C., and Cigliano, Maria M.

Abstract

Grasshoppers in the genus Ronderosia (divergence time < 5 Mya) provide a special opportunity to examine the impact of chromosome rearrangements (CRs) in evolution and speciation, because they exhibit extensively rearranged karyotypes involving autosome-autosome and autosome-X chromosomes, the latter leading to the formation of a neo-sex chromosome system (neo-SCS). Despite the potential role of CRs in speciation, the general patterns of karyotype changes resulting from CRs in Ronderosia are still unclear. Here we investigated karyotype evolution in eight Ronderosia species using cytogenetic and phylogenetic models of ancestral character reconstruction. The overall findings suggest a central role for CRs in generating variability in chromosome number and neo-SCS across Ronderosia grasshoppers. It also suggests that incipient species with little morphological change, such as those observed in Ronderosia species, could accumulate marked differences in their karyotypes contributing to post-zygotic reproductive isolation. Besides the evolution of chromosome number in the phylogeny of the genus, chromosome change due to centric fusion is coupled with the divergence pattern observed in the group. While a cladogenetic event could represent a case where karyotypic differences result in speciation, further in-depth genomic studies are needed to better understand how these dramatic restructurings of karyotypes may have occurred.

Published
2023
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99. Early Intubation in Endovascular Therapy for Basilar Artery Occlusion:A Post Hoc Analysis of the BASICS Trial

Author

Barlinn, Kristian, Langezaal, Lucianne C.M., Dippel, Diederik W.J., Van, Wim H., Roessler, Martin, Roos, Yvo B.W.E.M., Emmer, Bart J., van Oostenbrugge, Robert J., Gerber, Johannes C., Yoo, Albert J., Pontes-Neto, Octavio M., Mazighi, Mikael, Audebert, Heinrich J., Michel, Patrik, Schonewille, Wouter J., Puetz, Volker, Barlinn, Kristian, Langezaal, Lucianne C.M., Dippel, Diederik W.J., Van, Wim H., Roessler, Martin, Roos, Yvo B.W.E.M., Emmer, Bart J., van Oostenbrugge, Robert J., Gerber, Johannes C., Yoo, Albert J., Pontes-Neto, Octavio M., Mazighi, Mikael, Audebert, Heinrich J., Michel, Patrik, Schonewille, Wouter J., and Puetz, Volker

Abstract

BACKGROUND: The optimal anesthetic management for endovascular therapy (EVT) in patients with posterior circulation stroke remains unclear. Our objective was to investigate the impact of early intubation in patients enrolled in the BASICS trial (Basilar Artery International Cooperation Study). METHODS: BASICS was a multicenter, randomized, controlled trial that compared the efficacy of EVT compared with the best medical care alone in patients with basilar artery occlusion. In this post hoc analysis, early intubation within the first 24 hours of the estimated time of basilar artery occlusion was examined as an additional covariate using regression modeling. We estimated the adjusted relative risks (RRs) for favorable outcomes, defined as modified Rankin Scale scores of 0 to 3 at 90 days. An adjusted common odds ratio was estimated for a shift in the distribution of modified Rankin Scale scores at 90 days. RESULTS: Of 300 patients in BASICS, 289 patients were eligible for analysis (151 in the EVT group and 138 in the best medical care group). compared with medical care alone, EVT was related to a higher risk of early intubation (RR, 1.29 [95% CI, 1.09–1.53]; P<0.01), and early intubation was negatively associated with favorable outcome (RR, 0.61 [95% CI, 0.45–0.84]; P=0.002). Whereas there was no overall treatment effect of EVT on favorable outcome (RR, 1.22 [95% CI, 0.95–1.55]; P=0.121), EVT was associated with favorable outcome (RR, 1.34 [95% CI, 1.05–1.71]; P=0.018) and a shift toward lower modified Rankin Scale scores (adjusted common odds ratio, 1.63 [95% CI, 1.04–2.57]; P=0.033) if adjusted for early intubation. CONCLUSIONS: In this post hoc analysis of the neutral BASICS trial, early intubation was linked to unfavorable outcomes, which might mitigate a potential benefit from EVT by indirect effects due to an increased risk of early intubation. This relationship may be considered when assessing the efficacy of EVT in patients with basilar artery occlusion

Published
2023

100. What ethical conflicts do internists in Spain, México and Argentina encounter? An international cross-sectional observational study based on a self-administrated survey

Author

Antonio Blanco Portillo, Rebeca García-Caballero, Diego Real de Asúa, Karmele Olaciregui Dague, Octavio Márquez Mendoza, Pascual Valdez, and Benjamín Herreros

Subjects
Clinical bioethics, Internal Medicine, Culture, Mediterranean region, Hispanic, Medical philosophy. Medical ethics, R723-726
Abstract

Abstract Background The differences in clinical bioethics between the Mediterranean and Latin American cultures have not been analyzed. The objective of the study is to compare the ethical conflicts that internists in Spain, Mexico and Argentina have. Methods Cross-sectional observational study through a survey directed at internists from Spain, Argentina and Mexico. The survey was administered to affiliated members of the National Societies of Internal Medicine across three countries via an online platform. Results 762 internists participated, 261 from Spain, 154 from Argentina and 347 from Mexico. The main ethical conflicts that internists in Spain, Argentina and Mexico have are related (in order) to the end of life, to the clinical relationship and to the patient’s autonomy. Withholding and withdrawing life-sustaining treatment is the most frequent conflict in Spain and Argentina and the second in Mexico. Conclusions Internists from Spain and Argentina identify very similar ethical conflicts. Furthermore, they consider them more frequent and difficult than in Mexico. In Argentina they are less satisfied with the way they are resolved. To explain these differences, socio-cultural factors are postulated, among others: paternalism, individualism, masculinity, organization of the health system, formal training in bioethics and assessment of death.

Published
2024
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