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554 results on '"O'Sullivan, Jacintha"'

55. Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction

Author

Heeran, Aisling B., primary, McCready, Jessica, additional, Dunne, Margaret R., additional, Donlon, Noel E., additional, Nugent, Timothy S., additional, Bhardwaj, Anshul, additional, Mitchelson, Kathleen A. J., additional, Buckley, Amy M., additional, Ravi, Narayanasamy, additional, Roche, Helen M., additional, Reynolds, John V., additional, Lynam-Lennon, Niamh, additional, and O’Sullivan, Jacintha, additional

Published
2021
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56. Incorporating Clinicopathological and Immunological Profiling

Author

Donlon, Noel E., Davern, Maria, Sheppard, Andrew, Power, Robert, O’Connell, Fiona, Heeran, Aisling B., King, Ross, Hayes, Conall, Bhardwaj, Anshul, Phelan, James J., Dunne, Margaret R., Ravi, Narayanasamy, Donohoe, Claire L., O’Sullivan, Jacintha, Reynolds, John V., and Lysaght, Joanne

Subjects
immunophenotyping, tumour-draining lymph node, oesophageal adenocarcinoma, immune checkpoints, metastatic niche, prognostic
Abstract

Response rates to the current gold standards of care for treating oesophageal adenocarcinoma (OAC) remain modest with 15–25% of patients achieving meaningful pathological responses, highlighting the need for novel therapeutic strategies. This study consists of immune, angiogenic, and inflammatory profiling of the tumour microenvironment (TME) and lymph node microenvironment (LNME) in OAC. The prognostic value of nodal involvement and clinicopathological features was compared using a retrospective cohort of OAC patients (n = 702). The expression of inhibitory immune checkpoints by T cells infiltrating tumour-draining lymph nodes (TDLNs) and tumour tissue post-chemo(radio)therapy at surgical resection was assessed by flow cytometry. Nodal metastases is of equal prognostic importance to clinical tumour stage and tumour regression grade (TRG) in OAC. The TME exhibited a greater immuno-suppressive phenotype than the LNME. Our data suggests that blockade of these checkpoints may have a therapeutic rationale for boosting response rates in OAC.

Published
2021
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60. Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors

Author

Kennedy, Susan A., primary, Annett, Stephanie L., additional, Dunne, Margaret R., additional, Boland, Fiona, additional, O’Neill, Linda M., additional, Guinan, Emer M., additional, Doyle, Suzanne L., additional, Foley, Emma K., additional, Elliott, Jessie A., additional, Murphy, Conor F., additional, Bennett, Annemarie E., additional, Carey, Michelle, additional, Hillary, Daniel, additional, Robson, Tracy, additional, Reynolds, John V., additional, Hussey, Juliette, additional, and O’Sullivan, Jacintha, additional

Published
2021
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61. The Prognostic Value of the Lymph Node in Oesophageal Adenocarcinoma; Incorporating Clinicopathological and Immunological Profiling

Author

Donlon, Noel E., primary, Davern, Maria, additional, Sheppard, Andrew, additional, Power, Robert, additional, O’Connell, Fiona, additional, Heeran, Aisling B., additional, King, Ross, additional, Hayes, Conall, additional, Bhardwaj, Anshul, additional, Phelan, James J., additional, Dunne, Margaret R., additional, Ravi, Narayanasamy, additional, Donohoe, Claire L., additional, O’Sullivan, Jacintha, additional, Reynolds, John V., additional, and Lysaght, Joanne, additional

Published
2021
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63. Prognostic, Diagnostic and Predictive Biomarkers in the Barrett's Oesophagus-Adenocarcinoma Disease Sequence.

Author

O'Dowd, Darragh, O'Sullivan, Jacintha, and Marcone, Simone

Subjects
*ESOPHAGUS, *ADENOCARCINOMA, *BIOMARKERS, *EVALUATION of medical care, *RADIO frequency therapy, *EARLY detection of cancer, *INDIVIDUALIZED medicine, *CATHETER ablation, *BARRETT'S esophagus, *DIAGNOSTIC imaging, *COST effectiveness, *DISEASE management
Abstract

Simple Summary: Oesophageal adenocarcinoma (OAC) is a type of cancer of the oesophagus (food pipe) which is associated with poor patient outcomes. Barrett's oesophagus (BO) is a precancerous condition of the oesophagus associated with chronic heartburn. Currently, surveillance programs exist which monitor patients with BO to prevent it from developing into OAC. However, these surveillance programs are expensive and unpleasant for patients. Prognostic biomarkers are signs which could be measured to determine the chance of someone with BO developing OAC, allowing more targeted surveillance. Similarly, diagnostic biomarkers are indicators which could be measured to see if someone has OAC. Developing new diagnostic biomarkers could allow wider population testing. Only a small proportion of patients with OAC respond to treatment before surgery. Predictive biomarkers could be measured to predict whether someone would respond to the treatments, allowing more individualized therapy. This review focuses on potential biomarkers which could improve patient outcomes in BO/OAC. Oesophageal adenocarcinoma (OAC) incidence has increased dramatically in the developed world, yet outcomes remain poor. Extensive endoscopic surveillance programs among patients with Barrett's oesophagus (BO), the precursor lesion to OAC, have aimed to both prevent the development of OAC via radiofrequency ablation (RFA) and allow earlier detection of disease. However, given the low annual progression rate and the costs of endoscopy/RFA, improvement is needed. Prognostic biomarkers to stratify BO patients based on their likelihood to progress would enable a more targeted approach to surveillance and RFA of high-risk precursor lesions, improving the cost–risk–benefit ratio. Similarly, diagnostic biomarkers for OAC could enable earlier diagnosis of disease by allowing broader population screening. Current standard treatment for locally advanced OAC includes neoadjuvant chemotherapy (+/− radiotherapy) despite only a minority of patients benefiting from neoadjuvant treatment. Accordingly, biomarkers predictive of response to neoadjuvant therapy could improve patient outcomes by reducing time to surgery and unnecessary toxicity for the patients who would have received no benefit from the therapy. In this mini-review, we will discuss the emerging biomarkers which promise to dramatically improve patient outcomes along the BO-OAC disease sequence. [ABSTRACT FROM AUTHOR]

Published
2022
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64. Colonic oncostatin M expression evaluated by immunohistochemistry and infliximab therapy outcome in corticosteroid-refractory acute severe ulcerative colitis.

Author

O'Connell, Jim, Doherty, Jayne, Buckley, Amy, Cormican, David, Dunne, Cara, Hartery, Karen, Larkin, John, MacCarthy, Finbar, McCormick, Paul, McKiernan, Susan, Mehigan, Brian, Muldoon, Cian, Ryan, Ciara, O'Sullivan, Jacintha, and Kevans, David

Subjects
IMMUNOHISTOCHEMISTRY, INFLIXIMAB, ULCERATIVE colitis
Published
2022
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66. ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol

Author

O'Neill, Linda, primary, Guinan, Emer, additional, Brennan, Louise, additional, Doyle, Suzanne L., additional, O'Connor, Louise, additional, Sheill, Grainne, additional, Smyth, Emily, additional, Fairman, Ciaran M., additional, Segurado, Ricardo, additional, Connolly, Deirdre, additional, O'Sullivan, Jacintha, additional, Reynolds, John V., additional, and Hussey, Juliette, additional

Published
2021
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68. AB178. SOH21AS195. The importance of the lymph node: incorporating clinicopathological features with immunological modulation in tailored multimodal treatment for oesophageal adenocarcinoma

Author

Donlon, Noel Edward, primary, Davern, Maria, additional, Sheppard, Andrew, additional, Power, Robert, additional, Connell, Fiona O., additional, Heeran, Aisling, additional, King, Ross, additional, Hayes, Conall, additional, Bhardwaj, Anshul, additional, Ravi, Narayanasamy, additional, Donohoe, Claire, additional, O’Sullivan, Jacintha, additional, Reynolds, John, additional, and Lysaght, Joanne, additional

Published
2021
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74. The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses

Author

Heeran, Aisling B., primary, Dunne, Margaret R., additional, Morrissey, Maria E., additional, Buckley, Croí E., additional, Clarke, Niamh, additional, Cannon, Aoife, additional, Donlon, Noel E., additional, Nugent, Timothy S., additional, Durand, Michael, additional, Dunne, Cara, additional, Larkin, John O., additional, Mehigan, Brian, additional, McCormick, Paul, additional, Lynam-Lennon, Niamh, additional, and O’Sullivan, Jacintha, additional

Published
2021
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76. Radiation-induced Bystander Effect (RIBE) alters mitochondrial metabolism using a human rectal cancer ex vivo explant model

Author

Heeran, Aisling B., primary, Berrigan, Helen P., additional, Buckley, Croí E., additional, Bottu, Heleena Moni, additional, Prendiville, Orla, additional, Buckley, Amy M., additional, Clarke, Niamh, additional, Donlon, Noel E., additional, Nugent, Timothy S., additional, Durand, Michael, additional, Dunne, Cara, additional, Larkin, John O., additional, Mehigan, Brian, additional, McCormick, Paul, additional, Brennan, Lorraine, additional, Lynam-Lennon, Niamh, additional, and O'Sullivan, Jacintha, additional

Published
2021
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77. Additional file 5 of Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

Author

Kennedy, Susan A., Morrissey, Maria E., Dunne, Margaret R., O’Connell, Fiona, Butler, Clare T., Mary-Clare Cathcart, Buckley, Amy M., Mehigan, Brian J., Larkin, John O., McCormick, Paul, Kennedy, Breandán N., and O’Sullivan, Jacintha

Subjects
chemical and pharmacologic phenomena, hemic and immune systems
Abstract

Additional file 5 Figure S3. Flow Cytometry Analysis: A The experimental outline is illustrated describing the incubation of (i) DC preparations for the specified time and (ii) the conditions to which the cells were exposed, specifically IL-4 and GM-CSF cytokines to derive the DCs, conditioned media from the TCM to precondition the DCs and LPS to mature the DCs. Finally, DCs were analyzed by flow cytometry and DC supernatants were analyzed by ELISA. B-C The gating strategy of the monocyte-derived DCs is shown of singlet, monogate cells which are CD11c + (B) and the Fluorescence Minus One staining controls (C).

Published
2020
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78. Additional file 1 of Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

Author

Kennedy, Susan A., Morrissey, Maria E., Dunne, Margaret R., O’Connell, Fiona, Butler, Clare T., Mary-Clare Cathcart, Buckley, Amy M., Mehigan, Brian J., Larkin, John O., McCormick, Paul, Kennedy, Breandán N., and O’Sullivan, Jacintha

Abstract

Additional file 1 Table S1. Patient characteristics including surgical details, and Tumor-Nodal-Metastasis (TNM) stage. The median age at the time of surgery 74.5 years (range: 62–82 years), with an equal number of males [4] & females [4]

Published
2020
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79. Privileged Structure: Novel Indane Scaffolds as Potential Anticancer and Anti-Inflammatory Agents

Author

Chan, Kit, Zhang, Tao, Bandero-Filho, Vilmar Cláudio, Moriarty, Andrew, McCormick, Paul, Mehigan, Brian, Mary Clare, Cathcart, Daly, Robin, Kennedy, Breandán, O'Sullivan, Jacintha, Frankish, Neil, and Sheridan, Helen

Subjects
Indane, 5-lipoxygenase, Life Sciences, plant, anticancer, anti-inflammatory
Abstract

The identification and use of “privileged structures” can increase the reliability and shorten the process in the drug discovery and drug design (a-b). Indane scaffolds occur in various natural products and they constitute the privileged structure that is ubiquitous in many biologically and pharmaceutically active molecules (c-e). Our research group has been working on the synthesis and pharmacological activity of nature identical and synthetically modified indanes and indanones for 20 years. In the current study, the molecular design is centred on elaboration of a fern derived bioactive pharmacophore. The fern is used in traditional Taiwanese medicine to treat inflammation, allergy, stomach cramps and fever (f). Using a synthetic approach we have designed a novel chemical scaffold which can be modified to inhibit angiogenesis and 5-lipoxygenase activity. The parent scaffold and a number of strategically modified derivatives were initially screened using the Zebra fish (Danio rerio) model of tumour angiogenesis (g). This screen led to the identification of two lead molecules, which were then further evaluated in in vitro cell lines and colorectal explants. Results from these experiments establish that the lead compounds affect inter-segmental vessel formation. These molecules also inhibit cell invasion and tube formation. When evaluated in ex vivo colorectal cancer explants where the molecules significantly affected angiogenic and inflammatory protein secretions. These small molecules also alter gene expression. Modification of the scaffold can inhibit 5-lipoxygenase activity. These data suggest that the new scaffold may have significant potential in the treatment of angiogenesis and inflammatory related diseases.

Published
2020

80. Additional file 1 of The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation

Author

Morrissey, Maria E., Róisín Byrne, Nulty, Celina, McCabe, Niamh H., Lynam-Lennon, Niamh, Butler, Clare T., Kennedy, Susan, O’Toole, Dermot, Larkin, John, McCormick, Paul, Mehigan, Brian, Mary-Clare Cathcart, Lysaght, Joanne, Reynolds, John V., Ryan, Elizabeth J., Dunne, Margaret R., and O’Sullivan, Jacintha

Abstract

Additional file 1 Supplementary Table 1. Patient demographics. Supplementary Fig. 1. Experimental outline and flow cytometry gating strategy and staining controls. Supplementary Fig. 2. ex vivo TCM from distinct gastrointestinal adenocarcinoma types induced differential effects on LPS-induced DC maturation. Supplementary Fig. 3. ex vivo TCM from distinct gastrointestinal adenocarcinoma types induced differential effects on unstimulated DC marker levels. Supplementary Fig. 4. in vitro TCM of 2Gy-irradiated cell lines from gastrointestinal cancers induced significant inhibition of DC markers compared to mock irradiation. Supplementary Fig. 5. ex vivo TCM of 2Gy-irradiated TME from gastrointestinal cancers inhibited DC markers compared to mock irradiation

Published
2020
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81. Additional file 3 of Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

Author

Kennedy, Susan A., Morrissey, Maria E., Dunne, Margaret R., O’Connell, Fiona, Butler, Clare T., Mary-Clare Cathcart, Buckley, Amy M., Mehigan, Brian J., Larkin, John O., McCormick, Paul, Kennedy, Breandán N., and O’Sullivan, Jacintha

Abstract

Additional file 3 Figure S1. Expression of angiogenic mediators in tumor conditioned media from resected CRC tissue. The MSD V-plex Angiogenesis panel 1 was used to determine the expression level of angiogenic markers in tumor conditioned media generated from resected patient CRC tissue (n = 8). Following drug treatment, no significant difference in expression level was observed for (A) bFGF, (B) PGF, (C) FLT-1, and (D) VEGF-C.

Published
2020
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82. Additional file 2 of Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

Author

Kennedy, Susan A., Morrissey, Maria E., Dunne, Margaret R., O’Connell, Fiona, Butler, Clare T., Mary-Clare Cathcart, Buckley, Amy M., Mehigan, Brian J., Larkin, John O., McCormick, Paul, Kennedy, Breandán N., and O’Sullivan, Jacintha

Subjects
sense organs, skin and connective tissue diseases
Abstract

Additional file 2 Table S2. Summary of significant results including fold-change.

Published
2020
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83. Additional file 4 of Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

Author

Kennedy, Susan A., Morrissey, Maria E., Dunne, Margaret R., O’Connell, Fiona, Butler, Clare T., Mary-Clare Cathcart, Buckley, Amy M., Mehigan, Brian J., Larkin, John O., McCormick, Paul, Kennedy, Breandán N., and O’Sullivan, Jacintha

Abstract

Additional file 4 Figure S2. Expression of pro-inflammatory mediators in TCM from resected CRC tissue. The MSD V-plex Proinflammatory panel 1 was used to determine the expression level of proinflammatory markers in tumor conditioned media generated from resected patient CRC tissue. Following drug treatment, no significant difference in expression level was observed for (A) IL-1β, IL-2, IL-4, IL-8, IL-12p70, and TNF-α.

Published
2020
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85. ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol

Author

O'Neill, Linda, primary, Guinan, Emer, additional, Doyle, Suzanne L., additional, O'Connor, Louise, additional, Sheill, Grainne, additional, Smyth, Emily, additional, Fairman, Ciaran M., additional, Segurado, Ricardo, additional, Connolly, Deirdre, additional, O'Sullivan, Jacintha, additional, Reynolds, John V., additional, and Hussey, Juliette, additional

Published
2020
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86. Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma—An Emerging Role for Chemokines

Author

Donlon, Noel E., primary, Sheppard, Andrew, additional, Davern, Maria, additional, O’Connell, Fiona, additional, Phelan, James J., additional, Power, Robert, additional, Nugent, Timothy, additional, Dinneen, Kate, additional, Aird, John, additional, Greene, John, additional, Nevins Selvadurai, Paul, additional, Bhardwaj, Anshul, additional, Foley, Emma K., additional, Ravi, Narayanasamy, additional, Donohoe, Claire L., additional, Reynolds, John V., additional, Lysaght, Joanne, additional, O’Sullivan, Jacintha, additional, and Dunne, Margaret R., additional

Published
2020
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87. Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT)

Author

O'Neill, Linda, primary, Knapp, Peter, additional, Doyle, Suzanne L., additional, Guinan, Emer, additional, Parker, Adwoa, additional, Segurado, Ricardo, additional, Connolly, Deirdre, additional, O'Sullivan, Jacintha, additional, Reynolds, John V., additional, and Hussey, Juliette, additional

Published
2020
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89. High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

Author

Slater, Kayleigh, primary, Heeran, Aisling B., additional, Garcia-Mulero, Sandra, additional, Kalirai, Helen, additional, Sanz-Pamplona, Rebeca, additional, Rahman, Arman, additional, Al-Attar, Nebras, additional, Helmi, Mays, additional, O’Connell, Fiona, additional, Bosch, Rosa, additional, Portela, Anna, additional, Villanueva, Alberto, additional, Gallagher, William M., additional, Jensen, Lasse D., additional, Piulats, Josep M., additional, Coupland, Sarah E., additional, O’Sullivan, Jacintha, additional, and Kennedy, Breandán N., additional

Published
2020
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90. Prediction of pathological response to neo‐adjuvant chemoradiotherapy for oesophageal cancer using vibrational spectroscopy

Author

Nguyen, Thi N. Q., primary, Maguire, Adrian, additional, Mooney, Catherine, additional, Jackson, Naomi, additional, Lynam‐Lennon, Niamh, additional, Weldon, Vicki, additional, Muldoon, Cian, additional, Maguire, Aoife A., additional, O'Toole, D., additional, Ravi, Narayanasamy, additional, Reynolds, John V., additional, O'Sullivan, Jacintha, additional, and Meade, Aidan D., additional

Published
2020
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92. Barrett’s Registry Collaboration of academic centers in Ireland reveals high progression rate of low-grade dysplasia and low risk from nondysplastic Barrett’s esophagus: report of the RIBBON network

Author

O’Byrne, Lisa M, primary, Witherspoon, Jolene, additional, Verhage, Roy J J, additional, O’Brien, Marie, additional, Muldoon, Cian, additional, Ryan, Ciara, additional, Buckley, Martin, additional, Murphy, Thomas, additional, Reynolds, Rob, additional, Patchett, Stephen, additional, Kay, Elaine, additional, Azam, Halsema, additional, Robb, William, additional, Arumugasamy, Mayilone, additional, Mathuna, Padraic Mc, additional, Leyden, Jan, additional, Gargan, Siobhan, additional, Doherty, Glen, additional, Sheahan, Kieran, additional, Collins, Chris, additional, Nath, Amar, additional, O’Sullivan, Jacintha, additional, Donohoe, Claire L, additional, Ravi, Narayanasamy, additional, O’Toole, Dermot, additional, and Reynolds, John V, additional

Published
2020
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93. Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT)

Author

O'Neill, Linda, primary, Knapp, Peter, additional, Doyle, Suzanne L., additional, Guinan, Emer, additional, Parker, Adwoa, additional, Segurado, Ricardo, additional, Connolly, Deirdre, additional, O'Sullivan, Jacintha, additional, Reynolds, John V., additional, and Hussey, Juliette, additional

Published
2019
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96. Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint

Author

Biniecka, Monika, Kennedy, Aisling, Fearon, Ursula, Ng, Chin Teck, Veale, Douglas J., and O'Sullivan, Jacintha N.

Subjects
Oxidative stress -- Measurement, Oxidative stress -- Research, Arthritis -- Development and progression, Arthritis -- Research, Biological markers -- Identification and classification, Biological markers -- Physiological aspects, Biological markers -- Research, Health
Published
2010

98. Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma

Author

Melo, Ashanty M., primary, O'Brien, Aisling M., additional, Phelan, James J., additional, Kennedy, Susan A., additional, Wood, Nicole A. W., additional, Veerapen, Natacha, additional, Besra, Gurdyal S., additional, Clarke, Niamh E., additional, Foley, Emma K., additional, Ravi, Akshaya, additional, MacCarthy, Finbar, additional, O'Toole, Dermot, additional, Ravi, Narayamasami, additional, Reynolds, John V., additional, Conroy, Melissa J., additional, Hogan, Andrew E., additional, O'Sullivan, Jacintha, additional, and Dunne, Margaret R., additional

Published
2019
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