72 results on '"Novoa RA"'
Search Results
52. Development of RET mutant cutaneous angiosarcoma during BRAF inhibitor therapy.
- Author
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Dai J, Kunder CA, Chu EY, Chan EF, Egan CL, and Novoa RA
- Subjects
- Aged, Awareness, Carcinogenesis drug effects, Carcinoma, Squamous Cell genetics, Disease Progression, Enzyme Inhibitors adverse effects, Enzyme Inhibitors therapeutic use, Fatal Outcome, Hemangiosarcoma drug therapy, Hemangiosarcoma radiotherapy, Humans, Indoles therapeutic use, Male, Melanoma complications, Melanoma radiotherapy, Melanoma surgery, Mitogen-Activated Protein Kinase 1 drug effects, Mutation, Physicians, Positron Emission Tomography Computed Tomography methods, Protein Kinase Inhibitors therapeutic use, Proto-Oncogene Proteins B-raf genetics, Skin Neoplasms drug therapy, Skin Neoplasms radiotherapy, Sulfonamides therapeutic use, Vemurafenib, Hemangiosarcoma genetics, Hemangiosarcoma pathology, Indoles administration & dosage, Indoles adverse effects, Melanoma pathology, Protein Kinase Inhibitors adverse effects, Proto-Oncogene Proteins c-ret genetics, Skin Neoplasms pathology, Sulfonamides administration & dosage, Sulfonamides adverse effects
- Abstract
Treatment with BRAF inhibitors may lead to paradoxical mitogen-activated protein kinase (MAPK) pathway activation and accelerated tumorigenesis in cells with preexisting oncogenic hits. This phenomenon manifests clinically in the development of squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) in patients treated with BRAF inhibitors. Cases of extracutaneous malignancies associated with BRAF inhibitors have also been reported. We present a case of a patient who developed a cutaneous angiosarcoma 6 months after initiation of vemurafenib therapy. Next-generation sequencing (NGS) revealed a mutation in RET, which lies upstream of the MAPK pathway. This case highlights that treatment with BRAF inhibitors may promote the accelerated growth of secondary malignancies. Physician awareness of the spectrum of secondary malignancies associated with BRAF inhibitor treatment will support their early detection and treatment., (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2017
- Full Text
- View/download PDF
53. Corrigendum: Dermatologist-level classification of skin cancer with deep neural networks.
- Author
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Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, and Thrun S
- Abstract
This corrects the article DOI: 10.1038/nature21056.
- Published
- 2017
- Full Text
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54. Gain of CD26 expression on the malignant T-cells in relapsed erythrodermic leukemic mycosis fungoides.
- Author
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Cedeno-Laurent F, Wysocka M, Obstfeld AE, Novoa RA, Vittorio CC, Kim EJ, Weng WK, and Rook AH
- Subjects
- Aged, Female, Humans, Biomarkers, Tumor, CD4-Positive T-Lymphocytes metabolism, CD4-Positive T-Lymphocytes pathology, Dermatitis, Exfoliative metabolism, Dermatitis, Exfoliative pathology, Dipeptidyl Peptidase 4 biosynthesis, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Leukemic, Leukemia, T-Cell metabolism, Leukemia, T-Cell pathology, Mycosis Fungoides metabolism, Mycosis Fungoides pathology, Neoplasm Proteins biosynthesis, Skin Neoplasms metabolism, Skin Neoplasms pathology
- Abstract
Loss of CD26 surface expression on the circulating malignant T-cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T-cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T-cells with high CD26 expression. Polymerase chain reaction studies and high-throughput sequencing analyses from peripheral blood mononuclear cells at presentation and relapse consistently showed an identical clonal T-cell receptor suggesting evolution of her original malignant clone which lacked CD26 expression. Interestingly, quantitative expression of the sialomucin, CD164, mirrored her clinical picture, thus favoring its reliability as a novel biomarker in CTCL., (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2017
- Full Text
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55. Dermatologist-level classification of skin cancer with deep neural networks.
- Author
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Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, and Thrun S
- Subjects
- Automation, Cell Phone statistics & numerical data, Datasets as Topic, Humans, Keratinocytes pathology, Keratosis, Seborrheic classification, Keratosis, Seborrheic diagnosis, Keratosis, Seborrheic pathology, Melanoma classification, Melanoma diagnosis, Melanoma pathology, Nevus classification, Nevus diagnosis, Nevus pathology, Photography, Reproducibility of Results, Skin Neoplasms pathology, Dermatologists standards, Neural Networks, Computer, Skin Neoplasms classification, Skin Neoplasms diagnosis
- Abstract
Skin cancer, the most common human malignancy, is primarily diagnosed visually, beginning with an initial clinical screening and followed potentially by dermoscopic analysis, a biopsy and histopathological examination. Automated classification of skin lesions using images is a challenging task owing to the fine-grained variability in the appearance of skin lesions. Deep convolutional neural networks (CNNs) show potential for general and highly variable tasks across many fine-grained object categories. Here we demonstrate classification of skin lesions using a single CNN, trained end-to-end from images directly, using only pixels and disease labels as inputs. We train a CNN using a dataset of 129,450 clinical images-two orders of magnitude larger than previous datasets-consisting of 2,032 different diseases. We test its performance against 21 board-certified dermatologists on biopsy-proven clinical images with two critical binary classification use cases: keratinocyte carcinomas versus benign seborrheic keratoses; and malignant melanomas versus benign nevi. The first case represents the identification of the most common cancers, the second represents the identification of the deadliest skin cancer. The CNN achieves performance on par with all tested experts across both tasks, demonstrating an artificial intelligence capable of classifying skin cancer with a level of competence comparable to dermatologists. Outfitted with deep neural networks, mobile devices can potentially extend the reach of dermatologists outside of the clinic. It is projected that 6.3 billion smartphone subscriptions will exist by the year 2021 (ref. 13) and can therefore potentially provide low-cost universal access to vital diagnostic care.
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- 2017
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56. Invasive Melanoma in a Patient with Congenital Ichthyosiform Erythroderma.
- Author
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Jaju P, Novoa RA, Swetter SM, and Sarin KY
- Subjects
- Adult, Female, Humans, Melanoma surgery, Neoplasm Staging, Skin Neoplasms surgery, Ichthyosiform Erythroderma, Congenital complications, Melanoma pathology, Skin Neoplasms pathology
- Abstract
We describe the case of a 26-year-old woman with a history of congenital ichthyosiform erythroderma (CIE) who initially presented with a stage IIA amelanotic melanoma on her forearm that was surgically excised. We also review the literature on CIE-associated skin cancers and discuss the possible contribution of ichthyosis to the risk of cutaneous malignancies. Our findings emphasize the importance of close lifelong skin cancer screening in individuals with CIE and highlight the unique malignancy risk of these individuals., (© 2016 Wiley Periodicals, Inc.)
- Published
- 2017
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57. Sarcoidosis and squamous cell carcinoma: a connection documented in a case series of 3 patients.
- Author
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Berg SA, Novoa RA, Stewart C, Sobanko JF, Miller CJ, and Rosenbach M
- Subjects
- Carcinoma, Squamous Cell diagnosis, Female, Humans, Male, Middle Aged, Risk, Sarcoidosis complications, Sarcoidosis diagnosis, Skin Diseases complications, Skin Diseases diagnosis, Skin Neoplasms diagnosis, Carcinoma, Squamous Cell pathology, Sarcoidosis pathology, Skin Diseases pathology, Skin Neoplasms pathology
- Abstract
Sarcoidosis is a chronic multisystem disease characterized by the formation of noncaseating granulomas in multiple organs, including the skin. An association between multisystem sarcoidosis and an increased risk for malignancy has been established. Dermatologists should be aware of the increased risk for nonmelanoma skin cancers in patients with sarcoidosis. We report a series of 3 patients with primarily cutaneous sarcoidosis who presented with new-onset cutaneous squamous cell carcinoma (SCC). Two patients were black women and 1 patient presented with lesions of cutaneous sarcoidosis arising concurrently with SCCs in the same location, distinguishable only by biopsy. These cases highlight the association between sarcoidosis and an increased risk for SCC. Because dermatologists may be the primary clinicians caring for these patients, it is important that they remain aware of the increased risk for cutaneous malignancies and that they have a low threshold for biopsy of new and unusual skin lesions. Furthermore, 2 patients were black women, a population not commonly affected by skin cancer, which further exemplifies the need for comprehensive skin examinations in black patients. Although the precise mechanism for an increased risk for malignancy in these patients requires further investigation, chronic inflammation and immune dysregulation may play a role.
- Published
- 2016
58. Low-dose radiotherapy for primary cutaneous anaplastic large-cell lymphoma while on low-dose methotrexate.
- Author
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Cornejo CM, Novoa RA, Krisch RE, and Kim EJ
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- Female, Head and Neck Neoplasms pathology, Humans, Lymphoma, Primary Cutaneous Anaplastic Large Cell pathology, Middle Aged, Radiotherapy, Skin Neoplasms pathology, Antimetabolites, Antineoplastic therapeutic use, Chemoradiotherapy methods, Head and Neck Neoplasms therapy, Lymphoma, Primary Cutaneous Anaplastic Large Cell therapy, Methotrexate therapeutic use, Skin Neoplasms therapy
- Abstract
Primary cutaneous anaplastic large-cell lymphoma (pcALCL) is part of a spectrum of CD30+ primary cutaneous lymphoproliferative disorders (pcLPDs) that also includes lymphomatoid papulosis (LyP). Localized radiotherapy at doses of 34 to 44 Gy is first-line treatment of pcALCL, but the use of low-dose radiotherapy for pcALCL has not been reported. We present the case of a patient with a history of pcALCL/LyP who was treated with low-dose radiotherapy while on oral low-dose methotrexate (MTX) once weekly. This report suggests that low-dose radiotherapy can be an effective palliative treatment of pcALCL. Low-dose radiotherapy may offer certain advantages over traditional radiotherapy, such as a more economical and efficient treatment for patients, potentially fewer short-term and long-term side effects, and the potential for concomitant use with low-dose MTX.
- Published
- 2016
59. Epidermotropic metastasis of primary lung adenocarcinoma.
- Author
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Scott GD, Kwong BY, and Novoa RA
- Subjects
- Adenocarcinoma of Lung, Biomarkers, Tumor analysis, Humans, Immunohistochemistry, Male, Middle Aged, Adenocarcinoma secondary, Epidermis pathology, Lung Neoplasms secondary, Skin Neoplasms secondary
- Abstract
Cutaneous metastasis of lung cancer is a rare event and usually portends a grim prognosis. Several cases of lung cancer with cutaneous metastasis have been reported, but these have been largely limited to the dermis. Here we describe a unique case of cutaneous metastatic lung adenocarcinoma largely limited to the epidermis, mimicking Paget's disease or a cutaneous adnexal tumor., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2016
- Full Text
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60. Multiple eccrine axillary hidrocystomas.
- Author
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Khosla D, Novoa RA, Merati M, Honda K, and Gerstenblith MR
- Published
- 2016
- Full Text
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61. Carpet beetle dermatitis: a possibly under-recognized entity.
- Author
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MacArthur KM, Richardson V, Novoa RA, Stewart CL, and Rosenbach M
- Subjects
- Aged, Animals, Dermatitis, Allergic Contact parasitology, Humans, Male, Coleoptera immunology, Dermatitis, Allergic Contact etiology
- Published
- 2016
- Full Text
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62. Immunohistochemical analysis of lichenoid reactions in patients treated with anti-PD-L1 and anti-PD-1 therapy.
- Author
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Schaberg KB, Novoa RA, Wakelee HA, Kim J, Cheung C, Srinivas S, and Kwong BY
- Subjects
- Aged, Aged, 80 and over, Antineoplastic Agents administration & dosage, Female, Humans, Male, Antineoplastic Agents adverse effects, B7-H1 Antigen antagonists & inhibitors, Lichenoid Eruptions chemically induced, Lichenoid Eruptions pathology, Programmed Cell Death 1 Receptor antagonists & inhibitors
- Abstract
Background: Recent advances in the immunotherapeutic treatment of cancer have led to the development of multiple new directed therapies including monoclonal antibodies that block the immune checkpoint T-cell receptor programmed death 1 (PD-1) and the PD-1 ligand, programmed death ligand 1 (PD-L1). Various immune-related toxicities have been associated with these drugs including, most commonly, skin rashes., Methods: Five cases of lichenoid dermatitis, including one case of lichenoid mucositis and one case of lichen sclerosus, associated with anti-PD-L1 and anti-PD1 therapy were compared with three biopsies of non-drug-related lichen planus (LP) and three lichen planus-like keratoses (LPLK) used as controls., Results: Histopathologic and immunophenotypic analysis of these lichenoid lesions demonstrated significantly greater histiocytic infiltrates than observed in control lichenoid reactions (p = 0.0134). We also observed increased spongiosis and epidermal necrosis. No significant differences were seen in expression of CD3, CD4:CD8, CD20, PD-1, CD25, Foxp3, CXCL13 and PD-L1 expression., Conclusions: These findings expand the literature of immune-related toxicities of PD-L1 and PD-1 blockade to include lichenoid dermatitis and lichenoid mucositis. Of note, these cutaneous side effects were amenable to topical treatment, without the need for medication dose reduction or discontinuation., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2016
- Full Text
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63. Acquired port-wine stain with superimposed eczema following penetrating abdominal trauma.
- Author
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Langenhan J, Novoa RA, and Pappas-Taffer L
- Subjects
- Administration, Cutaneous, Adolescent, Anti-Inflammatory Agents administration & dosage, Diagnosis, Differential, Eczema drug therapy, Eczema etiology, Humans, Male, Port-Wine Stain drug therapy, Port-Wine Stain etiology, Triamcinolone administration & dosage, Abdominal Injuries complications, Eczema diagnosis, Port-Wine Stain diagnosis, Wounds, Stab complications
- Abstract
Port-wine stains (PWSs), or capillary malformations, are common congenital lesions, but acquired lesions rarely present in the setting of trauma. We present the case of an 18-year-old man who developed a PWS and associated localized eczema following penetrating trauma to the left abdomen. The diagnoses were confirmed on biopsy. The patient's eczema improved with topical steroids. Magnetic resonance imaging of PWSs is recommended in order to rule out deeper arteriovenous malformations. More research is needed to elucidate the connection between PWS pathophysiology and the development of eczema.
- Published
- 2015
64. Meckel's Diverticulitis Presenting with Abdominal Pain and Angina.
- Author
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Novoa RA and Shaffer K
- Abstract
Meckel's diverticulum is the most common congenital gastrointestinal anomaly, and 2-4% of patients with a Meckel's diverticulum will subsequently develop complications, including intestinal hemorrhage, intestinal obstruction, and diverticulitis. Meckel's diverticulitis is infrequently included in the differential diagnosis of abdominal pain in older adults. We present a case of Meckel's diverticulitis in a 74 year-old male who presented with non-specific abdominal pain and angina. Here, multi-detector computed tomography (MD-CT) imaging provided a pre-operative diagnosis of Meckel's diverticulitis. We then offer a review of the epidemiology, anatomy, radiologic findings, and differential diagnosis of Meckel's diverticulitis. This case presents coronal and sagittal MD-CT reconstructions of Meckel's diverticulitis that have yet to be well-described in the literature.
- Published
- 2015
- Full Text
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65. Presentation of Acute Megakaryoblastic Leukemia Associated with a GATA-1 Mutation Mimicking the Eruption of Transient Myeloproliferative Disorder.
- Author
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Boos MD, Wine Lee L, Freedman JL, Novoa RA, Chu EY, and Perman MJ
- Subjects
- Antineoplastic Combined Chemotherapy Protocols, Biopsy, Needle, Diagnosis, Differential, Down Syndrome diagnosis, Follow-Up Studies, Humans, Immunohistochemistry, Infant, Leukemia, Megakaryoblastic, Acute diagnosis, Leukemia, Megakaryoblastic, Acute drug therapy, Leukemoid Reaction diagnosis, Male, Mutation, Rare Diseases, Risk Assessment, Treatment Outcome, Down Syndrome genetics, GATA1 Transcription Factor genetics, Genetic Predisposition to Disease, Leukemia, Megakaryoblastic, Acute genetics, Leukemoid Reaction genetics
- Abstract
Children with trisomy 21 are prone to developing hematologic disorders, including transient myeloproliferative disorder (TMD) and acute megakaryoblastic leukemia (AMKL). The papulovesicular eruption of TMD provides an important clue to the diagnosis. In contrast, AMKL rarely has associated cutaneous findings. We report the case of a 22-month-old child with trisomy 21 who presented with the acute onset of diffusely scattered and crusted papules, plaques, and vesicles. A thorough infectious evaluation was negative and the patient was unresponsive to empiric antibiotic and antiinflammatory therapies. Complete blood count (CBC) was notable for mild pancytopenia, with a normal peripheral smear. Two weeks later he was reassessed and found to have a population of blasts on repeat CBC. Subsequent evaluation ultimately led to a diagnosis of AMKL. This is the first reported case of a cutaneous eruption in a young child with Down syndrome and transformed AMKL. When children with trisomy 21 present with the acute onset of crusted papules and vesicles that cannot be accounted for by an infectious etiology, a diagnosis of AMKL should be considered even in the absence of a history of TMD., (© 2015 Wiley Periodicals, Inc.)
- Published
- 2015
- Full Text
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66. Erythrodermic Leukemia Cutis in a Patient With Pre-B-Cell Acute Lymphoblastic Leukemia.
- Author
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Novoa RA, Wanat KA, Rosenbach M, Frey N, Frank DM, and Elenitsas R
- Subjects
- Aged, Dermatitis, Exfoliative etiology, Dermatitis, Exfoliative metabolism, Fatal Outcome, Female, Humans, Leukemic Infiltration etiology, Skin chemistry, Dermatitis, Exfoliative pathology, Leukemic Infiltration pathology, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma complications, Skin pathology
- Abstract
The clinical differential diagnosis of erythroderma is extensive and includes both benign and malignant causes. The authors present an exceptional case of erythroderma secondary to pre-B-cell lymphoblastic leukemia cutis, with diagnostic findings on biopsy.
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- 2015
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67. Hypertensive emergency, matlike telangiectasias, and calciphylaxis in POEMS syndrome.
- Author
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Novoa RA, Honda KS, Campagnaro E, and Gerstenblith MR
- Subjects
- Adult, Female, Humans, Calciphylaxis etiology, Hypertension, Malignant etiology, POEMS Syndrome complications, Telangiectasis etiology
- Published
- 2014
- Full Text
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68. Cutaneous epithelioid melanocytic neurofibroma arising in a patient with neurofibromatosis-1.
- Author
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Novoa RA, Kovarik CL, Low DW, and Argenyi Z
- Subjects
- Biomarkers, Tumor analysis, Cell Differentiation, Child, Humans, Immunohistochemistry, Male, Melanocytes pathology, Neurofibromatosis 1 pathology, Skin Neoplasms pathology
- Abstract
Tumors expressing both melanocytic and neural features can pose a diagnostic challenge to the dermatopathologist and provoke questions regarding their lineage. We report a case of a tumor arising on the right cheek of a 9-year-old boy with neurofibromatosis type 1 (NF-1). This neoplasm featured nests of non-pigmented epithelioid cells arising within a neurofibroma. The entire tumor stained strongly with S100, whereas the epithelioid population stained with MART-1, HMB-45 and MiTF. The neoplasm shows only scattered Ki-67 positivity. This tumor represents a neurofibroma with portions that have undergone melanocytic differentiation (melanocytic neurofibroma). This exceedingly rare tumor represents a distinct entity from neurotized melanocytic nevi, combined melanocytic nevi or pigmented neurofibromas and provides further evidence that melanocytes arise indirectly from ventromedial neural crest-derived Schwann cell precursors., (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2014
- Full Text
- View/download PDF
69. Cutaneous complications in hematopoietic cell transplant recipients: impact of biopsy on patient management.
- Author
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Paun O, Phillips T, Fu P, Novoa RA, Honda KS, Lu KQ, and Lazarus HM
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult, Biopsy methods, Hematopoietic Stem Cell Transplantation adverse effects, Hematopoietic Stem Cell Transplantation methods, Skin pathology, Skin Diseases etiology, Skin Diseases pathology
- Abstract
The utility of cutaneous biopsies in directing the management of post-hematopoietic cell transplantation (HCT) eruptions remains uncertain. We retrospectively analyzed 439 consecutive HCT procedures for malignant hematologic disorders performed at our institution between January 2005 and December 2012; 192 patients underwent 430 cutaneous biopsies. The clinical and dermatopathologic diagnosis differed in 240 cases (56%). Biopsy results led to a change in therapy in 69 (16%) episodes. Seventeen of 69 management changes occurred in response to a clinical diagnosis of graft-versus-host disease and resulted in augmentation of systemic immunosuppression. The management was modified with similar frequencies with respect to concordance or discordance between the clinical and histopathologic diagnosis (P = .51). We used classification and regression tree (CART) analysis, a decision-modeling technique, to predict the biopsy yield as expressed by impact on clinical management in the allogeneic and autologous setting. The models were cross-validated and then tested against a validation subset, and they maintained a high negative predictive value and high specificity. Although skin biopsies may not be mandatory for either diagnostic or therapeutic reasons, in carefully chosen circumstances, this procedure can yield extremely important data. We believe a prospective study should be undertaken to evaluate current practice data and to validate our decision tree models., (Copyright © 2013 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
70. Acneiform eruptions associated with vemurafenib.
- Author
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Petukhova TA, Novoa RA, Honda K, Koon HB, and Gerstenblith MR
- Subjects
- Fatal Outcome, Female, Humans, Male, Melanoma drug therapy, Melanoma pathology, Middle Aged, Vemurafenib, Acneiform Eruptions chemically induced, Antineoplastic Agents adverse effects, Indoles adverse effects, Sulfonamides adverse effects
- Published
- 2013
- Full Text
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71. Vasculitis and panniculitis associated with vemurafenib.
- Author
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Novoa RA, Honda K, Koon HB, and Gerstenblith MR
- Subjects
- Female, Humans, Male, Middle Aged, Vemurafenib, Indoles adverse effects, Panniculitis chemically induced, Sulfonamides adverse effects, Vasculitis chemically induced
- Published
- 2012
- Full Text
- View/download PDF
72. Ecstasy use and its association with sexual behaviors among drug users in New York City.
- Author
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Novoa RA, Ompad DC, Wu Y, Vlahov D, and Galea S
- Subjects
- Adolescent, Adult, Female, Humans, Interviews as Topic, Male, New York City epidemiology, N-Methyl-3,4-methylenedioxyamphetamine pharmacology, Sexual Behavior, Substance-Related Disorders epidemiology
- Abstract
In the past two decades, recreational use of ecstasy has become a growing concern in the United States, although most studies assessing ecstasy use have focused on white, middle-class adolescents who use ecstasy during raves and in clubs. We assessed the prevalence of recent ecstasy use among predominantly minority heroin, cocaine, and crack users in New York City and the association between ecstasy and sexual risk above and beyond that of the other drugs. Between 2002 and 2004, injection and non-injection heroin, crack and cocaine users (N= 534) completed a risk behavior questionnaire that included items on ecstasy use. Logistic regression was used to investigate the relation between current ecstasy use and sexual behaviors. Of 534 illicit drug users, 69.7% were aged 25 years or older, 65.2% were Hispanic, 27.9% Black and 77.4% male; 36.7% were injectors. 17.2% of respondents reported recent (last six months) ecstasy use. In a multivariable logistic regression model, current ecstasy use was associated both with initiating sex before age 14 (adjusted odds ratio (AOR) = 1.51) and having two or more partners in the past two months (AOR = 1.86) after adjusting for age at study entry, current cocaine and marijuana use and being an injection drug user. This study suggests that ecstasy use may be more prevalent among urban drug users. Ecstasy use in urban settings, beyond clubs and raves, should continue to be monitored.
- Published
- 2005
- Full Text
- View/download PDF
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