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Intentional learning consists of the ability to learn how to learn, develop critical self-awareness and exercise full accountability for learning. It is highly effective in producing effective learners in a loosely structured learning environment in line with today's student-centric teaching-learning paradigm. Intentional learning equips students with the necessary skills to actively participate in, self-direct, and regulate their learning so they can fulfill their goals. Through this metamorphosis, students develop intrinsic motivation and self-efficacy for learning, laying the groundwork for lifelong learning capability. The foundational framework of intentional learning is: (1) Learner's trust and confidence in their learning capacity; (2) Learner highly engage in one learning and possessed critical awareness of what and how to learn; (3) Learner begins with the learning outcome in mind, realize the efforts required to unlearn, learn and unlearn with high valence; (4) Leaner able to master the learning content and learning objectives; and (5) Leaner able to exercise self-regulation and accountability in learning.

Abstract Background The Gas6/TAM (Tyro3, Axl, and Mer) receptor system has been implicated in demyelination and delayed remyelination in experimental animal models, but data in humans are scarce. We aimed to investigate the role of Gas6/TAM in neurodegenerative processes in multiple sclerosis (MS). Methods From a prospective 5-year follow-up study, soluble Gas6/TAM biomarkers were analyzed in cerebrospinal fluid (CSF) by enzyme-linked immunosorbent assay (ELISA) at baseline in patients with relapsing–remitting MS (RRMS) (n = 40), progressive MS (PMS) (n = 20), and healthy controls (HC) (n = 25). Brain volumes, including myelin content (MyC) and white matter (WM) were measured by synthetic magnetic resonance imaging at baseline, 12 months, and 60-month follow-up. Associations with brain volume changes were investigated in multivariable linear regression models. Gas6/TAM concentrations were also determined at 12 months follow-up in RRMS to assess treatment response. Results Baseline concentrations of Tyro3, Axl, and Gas6 were significantly higher in PMS vs. RRMS and HC. Mer was higher in PMS vs. HC. Tyro3 and Gas6 were associated with reduced WM (β = 25.5, 95% confidence interval [CI] [6.11–44.96, p = 0.012; β = 11.4, 95% CI [0.42–22.4], p = 0.042, respectively) and MyC (β = 7.95, 95%CI [1.84–14.07], p = 0.012; β = 4.4, 95%CI [1.04–7.75], p = 0.012 respectively) at 60 months. Patients with evidence of remyelination at last follow-up had lower baseline soluble Tyro3 (p = 0.033) and Gas6 (p = 0.014). Except Mer, Gas6/TAM concentrations did not change with treatment in RRMS. Discussion Our data indicate a potential role for the Gas6/TAM receptor system in neurodegenerative processes influencing demyelination and ineffective remyelination.

Abstract Background Individuals with diabetes and co-existing psychiatric disorders have more diabetes complications and lower life expectancy than those with diabetes but no co-existing psychiatric disorders. Psychiatric health professionals may have a role in improving these outcomes but often lack diabetes knowledge and skills. This study aims to examine the effectiveness of a diabetes training course for psychiatric health professionals on their diabetes knowledge and skills and clinical outcomes, diabetes support and diabetes distress among individuals with diabetes and psychiatric disorders treated in psychiatric outpatient clinics. Methods A pragmatic non-randomized controlled cluster trial was conducted in eight psychiatric outpatient clinics in Denmark. All psychiatric health professionals from four clinics participated in the diabetes training course (the intervention) and completed a questionnaire on experience of the training course and a 20-item pre- and post-test to measure diabetes knowledge and skills. Difference in pre- and post-tests were analyzed using t-tests. From August 2018 – June 2019, individuals with diabetes were recruited from the intervention clinics (n = 49) and from four control clinics continuing usual clinical practice (n = 57). Differences in clinical outcomes, diabetes support and diabetes distress between the intervention and control groups at six and 12 months after the training course, were analyzed using logistic and linear regression models adjusted for baseline levels. Results Psychiatric health professionals (n = 64) had more correct answers after completing the course, with a mean increase of 6.3 [95% CI 5.6 to 7.0] correct answers. A total of 49 and 57 individuals were recruited for the intervention and control group, respectively. At follow-up, individuals treated in the intervention group had lower levels (clinical improvement) of systolic blood pressure, but had lower receipt of annual assessment of blood pressure, and body mass index (BMI) (worsening of process measures). While there were observed differences in odds and means for several other outcomes, none of these received statistical significance (see Table 2 and Fig. 2). Conclusions Training psychiatric health professionals in diabetes care improved their diabetes knowledge and skills and improved clinical levels of systolic blood pressure in individuals treated in the intervention group. However, this training intervention was associated with a lower likelihood of receiving annual assessment of blood pressure and BMI. Trial registration ISRCTN registry registration number ISRCTN15523920, registration date: 02/10/2019.

Abstract Background The European Organization of Research and Treatment of Cancer (EORTC) has recently developed and validated a patient-reported outcome measure (PROM) for sexual health (SH) in cancer patients. Here, we present results from a secondary analysis of the EORTC QLQ-SH22 validation study. The objective was to investigate the impact of cancer treatment on SH over the disease trajectory into survivorship in patients who underwent curative treatment. Methods Participants completed the EORTC QLQ-SH22 and the EORTC QLQ-C30 assessing SH and Quality of Life. We analyzed differences in SH of patients on active cancer treatment compared to patients off-treatment (cross sectional group comparison) as well as changes in SH during the course of treatment (from pre-treatment to follow-up). Results Our sample consisted of n = 394 (66.2% females) curatively treated cancer patients with 34% of patients being on-treatment and 66% of patients being in their follow-up after primary treatment (off-treatment group). Compared to patients off- treatment, patients on active cancer treatment experienced less sexual satisfaction (p = .021, Cohen’s d = .36) and libido (p

Major international surveys and reports have considerably altered the expectations and outlooks of national policymakers in education over the last three decades. Through a comparative content analysis of bibliographies in policy documents, this article explores the intermediary bodies that facilitate salient interconnections between international organizations such as the Organization for Economic Cooperation and Development (OECD) and national policymakers and experts who prepare comprehensive school reforms in three Nordic countries: Denmark, Norway and Sweden. This article builds on a large Nordic research project that studied the transfer and translation of international policies in a Nordic reform context. It extends the study by examining the role of publishers as intermediary policy brokers that legitimize the usage of OECD knowledge as significant members of instrument constituencies. This study enhances our understanding of the variations in citation patterns across policy documents from three Nordic countries. It also investigates the extent to which differences in instrumental constituencies arise from institutional arrangements and the ideational foundations underpinning reform trajectories. Additionally, it examines the topics addressed by these reforms and the governments’ affiliations with new policy brokers supported by both public and private publishers.

Abstract The aim of this study was to investigate how self-rated health (SRH) reflects ongoing ill-health and how SRH is associated with previous ill-health and/or predicts future ill-health such as burnout, disturbed sleep, and somatic symptoms. The study used two waves from the population-based Västerbotten Environmental and Health Study in which 2 336 adult persons participated by answering a questionnaire at two time points three years apart. Hierarchical and logistic regression analyses were conducted, thus treating all variables both continuously (degree) and categorically (case). The analyses were performed both cross-sectionally and longitudinally. The results showed bidirectionality between suboptimal SRH and burnout, disturbed sleep and somatic severity caseness. Moreover, degree of poor SRH was more likely to occur simultaneously to high degrees of burnout and somatic severity than to degree of poor sleep quality. Also, caseness of burnout, disturbed sleep and somatic severity increased the risk of simultaneous suboptimal SRH. Finally, the results showed that degree of burnout three years earlier, predicted degree of poor SRH, and that degree of poor SRH predicted degree of sleep three years later. In conclusion, in a population-based, normal adult sample there is a bidirectional relationship between suboptimal SRH and caseness of burnout, disturbed sleep quality and somatic symptoms, but not between degree of these symptoms. The results can have implications for health care meeting patients complaining about poor general health.

Coping strategies, perceived environmental exposure control and mental distress appear to be important concepts in persons with symptoms associated with environmental factors (SAEF), but their interplay is not well documented. The objective was to investigate (i) use of coping strategies, (ii) prevalence of perceived exposure control, (iii) whether the control is associated with mental distress and SAEF type, and (iv) whether coping strategies are associated with mental distress in SAEF regarding chemicals (SAEF‑C), buildings (SAEF‑B), electromagnetic fields (SAEF‑EMF) and sounds (SAEF‑S) in a general population. Cross‑sectional population‑based data (n = 391) and validated questionnaire instruments were used to assess symptoms of anxiety, depression, burnout and sleep disturbance, applying analysis of covariance and hierarchical regression analysis. The most used problem‑ and emotion‑focused coping strategies were avoiding environments and accepting the situation, respectively. A majority of those with SAEF‑C (71.7%), SAEFF‑EMF (75.9%) and SAEF‑S (64.1%), but not SAEF‑B (36.4%) were able to control the adverse exposure, and low level of control was associated with anxiety, depression, burnout and sleep disturbance in all four SAEF types. Use of the strategies avoidance and eating/drinking/smoking were associated with depression, and reprioritizing with burnout. An implication of the results is that suitable coping strategies and perceived control may be considered as part of treatment of SAEF.

The use of technology in education is believed to enhance students' learning experience. Technology such as Augmented Reality (AR) is increasingly used in the classroom through the use of gamification. This study aims to examine students' experience in using a board game with web-based Augmented Reality named REV-OPOLY in their learning. REV-OPOLY's theme is on the emerging technology revolution concepts where in this board game, players can buy, rent and sell technologies through question cards to gain the opportunity to own the technology. AR is implemented into the game as the play pieces and part of the play cards. The respondents are the undergraduate students enrolled in Computer Application in Management course in Universiti Utara Malaysia. In this qualitative study, respondents will be tested through pre-test and post-test to compare the effectiveness and efficacy of REV-OPOLY compared to traditional methods of self-revision. The findings showed that 98.8% of the respondents are interest-ed in using REV-OPOLY in learning and 86.1% of them are satisfied with the structure of the game, mainly the multiplayer aspects of it (95.3%) which enforce interaction and discussion among the players (89.5%) and 93.0% agreed that they can learn better through the game as an informal learning medium. In this study, REV-OPOLY has shown to have received positive feedback from the respondents. Further research is required to assess the students' learning outcomes and experience of REV-OPOLY.

This study explored the implementation of the whole school approach (WSA) on social and emotional guidance (SEG) in rural primary schools in Sarawak, Malaysia. Regular teachers (N = 2,532) in Sarawak responded to an electronic survey. The theory of planned behavior (TPB) and the socio-emotional guidance model were employed to explore the level of implementing the WSA on SEG among the respondents. Factors affecting the intention to be involved in SEG were also explored. This paper provides insights for policymakers and educational administrators to promote the social and emotional well-being of rural students in a developing country.

Event planning, handled by the event planner, involves organizing and coordinating events. The growing number of event planning companies has created a competitive environment where all strive to be the top choice for event managers. Ranking event planners can be subjective, as it depends on specific event requirements. Therefore, it is a crucial stage in selecting the best event planner since many criteria need to be considered. This study aims to identify event planner contractors and rank the alternatives by applying Consistent Fuzzy Linguistic Preference Relations (CFLPR). CFLPR is chosen because it reduces the number of comparisons, streamlines the process, and prevents inconsistencies, especially with large amounts of data. As hierarchy levels increase, there are more comparisons to make, leading to inconsistent decisions. CFLPR is also used to address the event planner selection issue comprehensively, improving the consistency of Fuzzy AHP and handling fuzzy judgments. This method constructs matrices of fuzzy preference relations using linguistic variables. This study considered 10 criteria to rank 3 alternatives Through CFLPR execution, Persona Fiza Bridal emerges as the top choice, followed by Butik Pengantin Seriheza and Nwahyu Butik Pengantin & Kecantikan. These rankings are based on consistent fuzzy linguistic preference relations, with the highest value assigned the top ranking and the lowest the last. Persona Fiza Bridal is thus recommended as the ideal event planner for Rio Event Management.

Background: Mammary gland carcinoma is a malignant type of cancer that occurs in mammae tissue. Dimethylbenzene (α) anthracene (DMBA) is a carcinogenic agent that causes mammary cancer by damaging cellular DNA. Flavonoids found in the black soybean (Glycine max L. Merr) exhibit anti-carcinogenic effects. Aim: This study evaluated the anticarcinogenic effects of black soybean extract. Methods: The activity of flavonoid compounds in black soybean was determined in silico. Five groups of rats, four in each group, were established, consisting of a negative control, a positive control, and three treatment groups. Treatment included black soybean extract administration (i.e., T1 = 200, T2 = 400, and T3 = 800 mg of black soybean extract/kg body weight for 10 days). The observed parameters included the immunohistochemical analysis of BRCA1 and TNF-α. Results: Based on an in silico study, compounds from black soybeans are non-toxic. Functional annotation analysis revealed that most of the target proteins have a role in biological processes associated with cancer development. An in vivo analysis using an animal mammae cancer model indicated that black soybean extracts inhibited mammae cancer progression by attenuating TNF-α and BRCA1 expression. Conclusion: The most effective dosage of black soybean extract was 200 mg/kg body weight. An increase in BRCA1 and TNF-α expression may be related to the effects of catechin, daidzein, genistein, and glycitein, which are present in black soybeans. [Open Vet J 2024; 14(10.000): 2678-2686]

The Finite Control Set-Predictive Torque Control (FSC-PTC) is a practical and intuitive method to control an Induction Motor (IM). However, the challenge of this technique is the difficulty of tuning the weighting factor so that it performs optimally at all speeds. Hence, this paper proposes a new method for improving the optimization technique by automatically tuning the weighting factor using a flux controller. The flux controller is represented as a DC gain and designed to be proportional to the absolute value of the predicted stator flux error. This method eliminates the need for complex computation to select the suitable weighting factor while also efficiently regulating flux and torque. The proposed method is experimentally validated on a DS1104 controller board and compared to a constant flux weighting factor method that was tested under speed conditions. The results demonstrate that the new method can further decrease the torque ripple compared to the constant weighting factor while maintaining the flux ripple and harmonic distortion limits.

Objective: To address the lack of research on invasive group B Streptococcus (GBS) infections in Malaysia and Southeast Asia through a comprehensive analysis of GBS isolates obtained from hospitals. Methods: Medical records from patients with GBS infection isolated from the sterile site, such as blood and cerebrospinal fluid from 14 July 2019 to 15 December 2020, were reviewed from six major hospitals in Peninsular Malaysia. Inclusion criteria were invasive GBS, sterile sites and non-repeated GBS isolated from the same patients in the same admission. Viable isolates were re-identified for GBS and serotyped. Results: A total of 118 patients were eligible, with a majority of non-pregnant adults (76.3%). Over half of the patients (62.7%) had underlying medical conditions, with diabetes as the most common disease, followed by respiratory disease, renal disease, cardiovascular disease and skin and soft tissue disease. The most common manifestations were sepsis, followed by soft tissue abscess, diabetic foot ulcer, wet gangrene and cellulitis. The overall mortality was 7.6%. The most common serotype was serotype V. Conclusions: Invasive GBS infection among non-pregnant adults showed a rising trend, particularly among diabetic individuals. The study underscores the importance of reducing risk factors and highlights the necessity of developing GBS vaccination as a preventive strategy for both infants and adults.

Abstract Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem cell (ESC) self-renewal but is required for mouse ESC growth and differentiation. Reintroduction of a catalytically-impaired LSD1 (LSD1MUT) recovers the proliferation capability of mouse ESCs, yet the enzymatic activity of LSD1 is essential to ensure proper differentiation. Indeed, increased H3K4me1 in Lsd1 knockout (KO) mouse ESCs does not lead to major changes in global gene expression programs related to stemness. However, ablation of LSD1 but not LSD1MUT results in decreased DNMT1 and UHRF1 proteins coupled to global hypomethylation. We show that both LSD1 and LSD1MUT control protein stability of UHRF1 and DNMT1 through interaction with HDAC1 and the ubiquitin-specific peptidase 7 (USP7), consequently, facilitating the deacetylation and deubiquitination of DNMT1 and UHRF1. Our studies elucidate a mechanism by which LSD1 controls DNA methylation in mouse ESCs, independently of its lysine demethylase activity.

In response to the reform in the Malaysian market that requires all publicly listed companies (PLCs) to have at least one female director on the board, this study examines how female directors’ attributes (FDAs) shape integrated reporting quality (IRQ) and assesses the potential influence of substantial shareholders on the FDA–IRQ nexus. Using all Malaysian PLCs implementing the integrated reporting from 2017 to 2021, our analysis yields four key findings. First, a positive relationship exists between the presence of a Muslim female director and IRQ. Second, female directors with financial expertise and those with higher education positively impact IRQ. Third, the holding of multiple directorships by female directors is negatively linked to IRQ, and the length of their tenure shows no significant effect. Fourth, the relationship between FDAs and IRQ is more pronounced in contexts with a greater ownership concentration. These results remain robust after rigorous analysis and mitigating for potential biases. Our findings offer valuable insights for policymakers, practitioners, and researchers interested in understanding the implications of gender diversity and IRQ in emerging markets.

Abstract The diverse applications of magnetorheological elastomer (MRE) drive efforts to understand consistent performance and resistance to failure. Stress relaxation can lead to molecular chain deterioration, degradation in stiffness and rheological properties, and ultimately affect the life cycle of MRE. However, quantifying the energy and molecular dynamics during stress relaxation is challenging due to the difficulty of obtaining atomic-level insights experimentally. This study employs molecular dynamics (MD) simulation to elucidate the stress relaxation in MRE during constant strain. Magnetorheological elastomer models incorporating silicone rubber filled with varying magnetic iron particles (50–80 wt%) were constructed. Experimental results from an oscillatory shear rheometer showed the linear viscoelastic region of MRE to be within 0.001–0.01% strain. The simulation results indicated that stress relaxation has occurred, with stored energies decreased by 8.63–52.7% in all MRE models. Monitoring changes in energy components, the highest final stored energy (12,045 kJ) of the MRE model with 80 wt% Fe particles was primarily attributed to stronger intramolecular and intermolecular interactions, revealed by higher potential energy (3262 kJ) and van der Waals energy (− 2717.29 kJ). Stress relaxation also altered the molecular dynamics of this MRE model as evidenced by a decrease in kinetic energy (9362 kJ) and mean square displacement value (20,318 Å2). The MD simulation provides a promising quantitative tool for elucidating stress relaxation, preventing material failure and offering insights for the design of MRE in the nanotechnology industry.

Background: Atrioventricular nodal re-entrant tachycardia (AVNRT) is the most common paroxysmal supraventricular tachycardia. We sought to investigate the incidence of atrial fibrillation in patients with electrophysiologically confirmed/ablated AVNRT and its association with transient ischemic attack (TIA)/stroke as well as mortality during long-term follow-up. Methods: From the Karolinska Ablation Registry, 2855 consecutive patients with a first-time ablation for AVNRT between 2005 and 2018 were analyzed. Results: Patients were 52.1 ± 15.9 years old and 59.3% were women. During follow-up of up to 10 years (median 6.0 years; interquartile range 3.3 to 9.2 years), new onset or recurrence of atrial fibrillation occurred in 317 (11.1%) patients (incidence rate 19 cases per 1000 person-years). Excluding those with history of atrial fibrillation, new onset of atrial fibrillation occurred in 153 (6.1%) patients. In multivariable analysis, history of atrial fibrillation, arterial hypertension, history of TIA/stroke, and heart failure remained independently associated with new onset or recurrence of atrial fibrillation during follow-up. Death of any cause and TIA/stroke occurred in 141 (4.9%) patients and 107 (3.7%) patients, respectively. In multivariable analysis, occurrence of atrial fibrillation during follow-up remained independently associated with both outcomes. The prevalence of atrial fibrillation according to age at the end of follow-up was high among young patients (

Purpose: This study aims to explore how the integration of augmented reality (AR) filters into English as a second language (ESL) can enhance speaking fluency teaching. The study sheds light on how AR filter can be best implemented in speaking fluency teaching by the innovative opportunities to transform language learning experiences. In this study, ESL teachers' perceptions and experiences with AR filters in speaking fluency instructions were examined through qualitative research method. Design/methodology/approach: This study is an evaluation stage study within a bigger study which utilized design and developmental research (DDR) approach. In this third phase of DDR which is the evaluation phase, this study involved semi-structured interviews with six ESL teachers from six different public secondary school settings. Thematic analysis was conducted on the interview transcripts. Findings: Data analysis revealed several key findings regarding the utilization of AR filters in ESL speaking fluency teaching. Firstly, participants reported that AR filters can be best used in various educational settings. Secondly, AR filters were found to provide supports for various students' levels. Thirdly, participants identified that AR filters can be best used to cater students with diverse learning styles. Research limitations/implications: The work aims to help ESL educators in using AR filters in their speaking fluency teaching. The limitation of this study is that it includes only the experience of teachers from a public secondary school setting without taking into consideration other secondary institutions such as ESL teachers from private schools or boarding schools. The generalizability of our findings may be affected due to our reliance on self-reported data from a small sample size. Practical implications: The implications of these findings for ESL pedagogy and teacher professional development are discussed. By incorporating AR filters into ESL speaking fluency instruction, educators can create speaking fluency teaching in various settings such as formal and informal settings. Furthermore, ESL teachers may immerse students in environments that cater to the diverse language learners' styles and language levels through the use of AR filter. Overall, this research contributes to a deeper understanding of the potential of AR filters to transform ESL teaching and learning practices, paving the way for future innovations in language education. Originality/value: Available studies exploring AR in English teaching exist, but very limited of those utilized markerless AR, in the form of AR filters with speaking fluency teaching. Also, this paper focused on teachers' experience with AR filters in contrast to students' experience in public secondary school settings.

This study examines the reference societies of Norway and Sweden embedded in their education policy documents. We examined 4,260 bibliographic references in 19 white papers and green papers prepared for the 2016/2020 renewal of the Knowledge Promotion Reform in Norway and the 2015/2018 Knowledge Achievement Reform in Sweden. In addition, we interviewed 10 policy experts who participated in the preparation of the analyzed policy documents. The results show that the reference societies overall reflect the existing knowledge production and dissemination mechanisms in education policy; however, they significantly differed between Norway and Sweden regarding whether and to what extent they reference knowledge produced in other Nordic countries. Specifically, while Norway drew extensively on knowledge from its neighbors, particularly Sweden, Sweden seldom referenced knowledge produced in other Nordic countries. Policy actors identified similarity, relevance, accessibility, reform contexts, and institutional arrangements as reasons for (not) referencing neighbors. This study calls for further consideration of the political, social, and cultural embeddedness of the 'socio-logic' to understand implicit reference societies.

This study investigates the impact of principals' instructional leadership practices on secondary school teachers' effectiveness in the North Central Geo-Political Zone of Nigeria. To answer the research question of the study, the Principal Instructional Management Rating Scale (PIMRS) and the Virgilio Teacher Behaviour Inventory (VTBI) were administered to 389 teachers in 18 public secondary schools. The results indicate that instructional leadership, in terms of defining school mission; managing instructional programs; and developing a positive school learning climate, are significantly and positively associated with teachers' effectiveness. Therefore, stakeholders in the education sector can make informed decisions and interventions to enhance teachers' effectiveness through the principals for desirable learning outcomes. Similarly, school principals should focus more on instructional leadership practices that relate to teaching and learning in order to improve teachers' effectiveness. This study adds to the existing knowledge on factors that determine teachers' effectiveness in Africa, in particular, in Nigeria.

The aim of this article is to explore the interrelationships between a national government and the Organisation for Economic Co-operation and Development (OECD) in terms of the power and legitimization of education reforms, here based on the reciprocal dependence of the two actors. Although the current case study only analyses the shifting relationships between Sweden and the OECD, the assumption is that the case is quite representative of the ambiguities of power in the relationships between the OECD and its smaller member countries and the Nordic countries in particular. To explore the relationship between the Swedish national government and OECD, we make use of discursive institutionalism as a general framework. For a closer understanding of the standpoints of the OECD and Sweden on different matters and at different times, two explanation logics are used. The discourses we found characterizing the different kinds of relationships over time are a discourse of opposition, a discourse of mentorship and a discourse of subordination. We argue that there are both ideational and institutional reasons affecting the conditions for cooperation on educational policy. Although institutional reasons strengthen the maintenance of the cooperation, ideational reasons both challenge and develop the nature of the collaboration between the OECD and Sweden.

Pyrethroid pesticides are essential for modern agriculture, helping to control pests and protect crops. However, due to growing concerns about their potential impact on human health and the environment, reliable detection methods are essential to ensure food safety. In this literature review, we explore the techniques used over the past decade to detect pyrethroid residues in agricultural products. Until now, various methods have been developed for detecting pyrethroid pesticides, ranging from conventional analytical approaches to innovative approaches. The conventional analytical approaches include gas, liquid, and supercritical fluid chromatography, micellar electrokinetic capillary chromatography, and enzyme-linked immunosorbent assay. Whereas innovative approaches refer to various optical-based and electrochemical-based sensors. For each method, we evaluate its strengths, limitations, and practical applications. Recent innovations are highlighted, focusing on sensitivity, selectivity, and practical applicability. By summarizing the current state of research, this review serves as a valuable resource for researchers and practitioners, providing insights into the evolving technology and strategy for detecting pyrethroid residue.

This article argues for the problematic dominance of education research striving for relevance for policy and practice, with little to no consideration of its contribution to shared internal disciplinary discourse. Drawing on non-affirmative education theory, we use empirical examples from the Swedish context to contend that such a one-sided focus on external relevance may lead to a relevance paradox in which education research becomes increasingly irrelevant while striving for relevance. Two issues are discussed in relation to this development. First, such a discourse on education research runs the risk of becoming undisciplined in the sense that it becomes detached from the shared disciplinary language, with little to no connection to fundamental education theory. Second, education research runs the risk of becoming uncritical. In closing the gap between practice/policy and research, education researchers jeopardise their critical distance and become subordinated to practitioners and policymakers in an unequal and uncritical relationship. Finally, we argue for a more dynamic and reflexive understanding of the relevance of education research, where the reflexive relationship between policy/practice and fundamental education theory research is understood as the thing that makes it possible for disciplinary discourse to thrive.

Even though mobile tourism analysis is developing, there is still a lack of literature regarding its formation patterns which makes the picture of its evolution incomplete. The evaluation in this study was carried out in general by emphasizing the evolution of exploratory analysis on the theme of "mobile tourism". This article aims to determine the increasing development of mobile tourism in terms of the number of publications, journals, authors, and the most relevant citations. Then analyze the itinerant tourism distribution map based on grouping, with merging, joint citation, collaboration network analysis, and joint word assessment, and interpret the conceptual structure of the country's co-occurrence and collaboration network regarding its visual representation. The method used is a descriptive approach through bibliometric analysis. An in-depth search of the Scopus database and RStudio software was conducted, screening, analyzing, and interpreting 752 relevant articles from 2014 to 2023. The findings show that an increase in the development of mobile tourism is identified from an increase in the number of publications, the most relevant journals, and authors, as well as the increasingly diverse origins of the authors even though the number of annual average citations has decreased slightly. Recommended six themes in mobile tourism studies, namely Tourism, Technology Acceptance Models (TAM), Mobile Applications, Recommendation Systems, Loyalty, and Cultural Tourism, and produced Technology Acceptance Models and Tourism as important studies with great prospects in the future.

Pineapple peel extracts constitute bioactive compounds that degrade due to light, oxidation, and moisture. This study aimed to encapsulate cellulase-treated MD2 pineapple peel extracts ensuring stability of bioactive compounds-rich extracts in the form of powders. Two drying methods were employed including spray-drying (150 °C) and foam-mat drying (60 °C) using maltodextrin (5 % v/v and 10 % v/v) and gum Arabic (GA) (5 % v/v and 10 % v/v) as carrier agents. Spray-drying for all microencapsulated powders exhibited high-quality powder with lower water activity (0.35–0.44), particle size diameters (D50) ranging from 19.7 to 53.71 μm and higher solubility index (75.42–98.53 %) in comparison to foam-mat drying. Spray-drying using 10 % GA exhibited the highest encapsulation efficiency (EE%) of above 99 % and further extraction of different phenolic fractions is shown to be the most efficient encapsulation of insoluble-bound phenolic (IBP). Bioactive volatile compounds comprised of 2-Methoxy-4-vinylphenol and Phenol, 2,4-bis(1,1-dimethylethyl) in the microcapsules of 10 % GA. Cellulase-treated MD2 pineapple peel extract powder containing 10 % GA exhibited low in toxicity effect (IC50 > 1000 μg/mL) against NIH3T3 fibroblast cells. Microcapsule powder from bioactive-rich extracts of cellulase-treated MD2 pineapple peel has the potential to be used in functional foods, nutraceuticals, pharmaceuticals, and cosmetics ingredients.

This scoping review explores what is currently understood about how masculinity norms interplay with loneliness and social connectedness among men in a Western context. Human beings inherently need social connections, and this review particularly addresses how traditional masculinity norms—emphasizing independence, emotional stoicism, and pain endurance—can increase vulnerability to loneliness and insufficient social connections. The review followed the Joanna Briggs Institute (JBI) methodology for scoping reviews and systematically assessed the literature published between September 2013 and September 2023. Initial literature searches were conducted using multiple databases, including EBSCO and PubMed. Of the 1,730 articles identified, 13 studies met the inclusion criteria and were quality assessed. Results show that men often formed social connections through productive activities. Still, these connections were restricted by conflicting masculine ideals such as self-reliance, which could be prioritized over social and emotional support. Masculine bonds were often formed and strengthened through collectively rejecting diversity. Nevertheless, there were some narratives where participants attempted to redefine masculinity to access permission to care and connect. This review highlights the urgent need for cultural and societal reevaluation of gender norms to support men’s social connectedness. This shift could reduce stigma around emotional vulnerability and in turn men’s opportunities for health and well-being.

Business will prosper if the environment is conducive to talent gathering. If the environment is nurturing and transformative for workers, it will attract and retain global talent. This study clarifies China’s global talent management policies through a quantitative analysis of the content of global talent management policy texts. We selected two dimensions to explore, namely, policy instrument types and management functions, and constructed a quantitative analysis framework of global talent management policy texts in China. Utilizing the Chinalawinfo Pkulaw Database, which is jointly launched by Peking University and Chinalawinfo Co. Ltd., the keywords “global talent,” “foreign experts,” and “foreign employees” were searched and a total of 145 relevant policy texts were selected. Based on the results, we recommend that for the formulation of future policies of global talent management, the frequency of using policy instruments of customs and traditions should be increased. Additionally, we should promote the integration and cross-cultural adaptation of global talent and strengthen the recognition of foreigners within Chinese culture.

Examining the physical aging of materials is essential for assessing their long-term performance and determining their suitability for specific applications. Material aging involves changes from their initial state, including deterioration or degradation. A key example of such a progressive, continuous process is the aging of materials in response to natural weathering conditions. While extensive research has focused on macro- and micro-scale aging, further investigation at the nanoscale could provide a more detailed understanding of material deterioration. This study explores the nanomechanical properties of magnetorheological elastomers (MREs) after nine months of natural weathering, focusing on stiffness, elasticity, surface roughness, and adhesion at the nanometer scale. Atomic Force Microscopy (AFM) with a sharp tip affixed to a cantilever was employed to characterize these properties. After nine months of exposure to natural weathering, MREs exhibited unique nanomechanical changes compared to their bulk properties, highlighting the significance of nanoscale analysis. At the nanoscale, the nanomechanical properties of MREs, including stiffness and elasticity, exhibited noticeable alterations within the first month of exposure, followed by a gradual reduction, and slight increments observed up to the nine-month mark. Surface roughness steadily increased over the nine months, while adhesion energy initially rose during the first month before gradually decreasing by the end of the study. These findings provide valuable insights into the material's mechanical behavior and offer a deeper understanding of its structural and functional properties at the nanoscale.

Virtual reality (VR)-based therapy has demonstrated potential in enhancing upper and lower limb functions, postural control, and balance. Despite its growing use, evidence regarding its impact on physical function and quality of life (QoL) in individuals with cerebral palsy (CP) remains scarce. This study protocol outlines a randomized controlled trial (RCT) designed to evaluate the efficacy of VR-based therapy as an adjunct to conventional therapy on physical function and QoL in adolescents with CP, as well as to explore the perceptions of participants and their caregivers regarding the intervention. This RCT will include 56 adolescents with CP, aged 10-17 years, who will be randomly assigned in a 1:1 ratio to either the intervention group (VR-based therapy) or the control group. Both groups will receive their usual conventional therapy, equated between groups. Additionally, the intervention group will receive VR therapy using the Xbox 360 Kinect, delivered twice weekly in 45- to 60-minute sessions for 12 weeks. Outcome measures will include the Gross Motor Function Measure-88, the 6-Minute Walk Test, handheld dynamometry, and the Paediatric Quality of Life Inventory. Assessments will be conducted at baseline, mid-intervention (week 6), and post-intervention (week 12). Qualitative data will be collected through semi-structured interviews with participants and caregivers after the 12-week program. Statistical analyses will be conducted on an intention-to-treat basis. Repeated measures ANOVA will be used to evaluate changes in physical function and QoL over time at baseline, mid- and post-intervention. The qualitative data from interviews will be analyzed using thematic analysis to identify key themes related to the experiences and perceptions of caregivers and participants.

Burnout is an increasing public health problem. Although research indicate that cognitive and affective factors are related to burnout, there is a lack of knowledge about the extent to which specific cognitive and affective symptoms are related to burnout, and whether there are sex-related differences. An aim of this study was to identify specific self-reported cognitive and affective symptoms that are particularly associated with burnout, both in the population in general and in men and women separately. Another aim was to examine the risk of burnout for specific symptoms and total number of symptoms in the general population and in men and women separately. Cross-sectional data were used from a large population-based questionnaire study consisting of 3406 participants (18–79 years) randomly selected from a general population in northern Sweden. Eleven cognitive and affective symptoms were assessed with a subsection of the Environmental Hypersensitivity Symptom Inventory, and the 22-item Shirom-Melamed Burnout Questionnaire (SMBQ) was used to assess burnout. The findings suggest that burnout is associated with a rather large number of cognitive and affective symptoms, in particular feeling tired/lethargic, having concentration difficulties, sleep disturbance, feeling depressed and being absent minded. Women with burnout (SMBQ score ≥ 4) reported higher prevalence of feeling tired/lethargic and sleep disturbance. The results add to the understanding of affective and cognitive symptomatology in burnout, which might have implications for early identification and prevention of burnout and exhaustion disorder.

The growing global concern about food security will be exacerbated by a projected population increase of nearly 10 billion by the year 2050. Rice cultivation is central to this discussion, as it feeds more than half of the world’s population. This systematic review addresses the urgent issue of global food security with an emphasis on sustainable rice farming. Traditional rice cultivation methods pose significant environmental challenges, such as methane emissions and high carbon footprints. Despite the increasing body of work on sustainable rice farming techniques, a gap exists from the absence of consolidated reviews. This study synthesised existing literature from SCOPUS and Web of Science databases according to PRISMA guidelines. Under strict inclusion and exclusion criteria, 49 of the initial 3259 studies identified were analysed. This present study established three pivotal factors influencing the adoption of sustainable practices among rice farmers: individual characteristics, community and social variables, and institutional frameworks. These elements hold crucial implications for policy formulation and provide a foundation for multidisciplinary collaboration to foster sustainable rice farming. This study fills a critical research void by delineating the key parameters that guide the adoption of sustainable practices within the rice farming community.

Background: The interplay of OGG1, 8-Oxoguanine, and oxidative stress triggers the exaggerated release of cytokines during malaria, which worsens the outcome of the disease. We aimed to investigate the involvement of OGG1 in malaria and assess the effect of modulating its activity on the cytokine environment and anemia during P. berghei malaria in mice. Methods: Plasmodium berghei ANKA infection in ICR mice was used as a malaria model. OGG1 concentration and oxidative stress levels in P. berghei-infected mice and their control counterparts were assessed during malaria using enzyme-linked immunosorbent assay. OGG1 activity in malaria mice was modulated using treatment with TH5487 and O8-OGG1 inhibitors. The effects of modulating OGG1 activity using OGG1 inhibitors on cytokine release and anemia during P. berghei malaria infection were assessed by cytometric bead array and measurement of total normal red blood cell count respectively. Results: The plasma OGG1 level was significantly upregulated and positively correlated with parasitemia during P. berghei malaria in mice. Modulation of OGG1 ameliorated malaria severity by improving the total normal RBC count in TH5487 and O8-treated mice. Modulation of OGG1 with TH5487 caused significant reductions in serum levels of TNF-α, IFN-γ, IL-6, and IL-10. Similarly, OGG1 modulation activity using an O8-OGG1 inhibitor caused a significant reduction in serum levels of TNF-α, IL-2, IL-6, and IL-10. Conclusion: The findings indicate the involvement of OGG1 in the P. berghei malaria infection. OGG1 inhibition by TH5487 and O8-OGG1 inhibitors suppressed excessive cytokine release, and this may represent a novel therapeutic strategy for ameliorating the severity of malaria infection.

The primary function of banks is to gather public deposits and extend credit. While banks aim for profit, they also play a crucial role in enhancing societal welfare, which requires adherence to prudential principles. Unfortunately, banking crimes committed by managers often occur, adversely affecting both the institutions and the public. This study explores the application of prudential principles in banking as a state responsibility, the nature of violations associated with banking crimes, and the enforcement of Banking Law in Indonesia. The research analyzes court decisions related to banking crimes from 2015 to 2020, focusing on the relevant legal substances. Employing a judicial normative method that includes statutory, conceptual, and case analyses, the findings indicate that violations typically arise from managers with decision-making authority and access to internal data, leading to breaches of Banking Law and standard operating procedures (SOPs). Courts respond to these violations with criminal sanctions, while the Financial Services Authority (OJK) revokes licenses as necessary. Recommendations include appointing OJK supervisors with banking expertise and clarifying Article 49, paragraph (2), letter b of the Banking Law to prevent misinterpretation.