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In 2014–15, Pakistan’s provincial government of Khyber Pakhtunkhwa (KPK) launched a decentralised power generation initiative, installing over 356 small hydro power units to provide electricity to over 2.5 million people in its mountainous regions. This initiative built on the foundation of prior community-based mini/micro hydro-power projects (MHPPs) deployed in the region since the 1980s that have experienced mixed success; by 2020, over 150 units were non-operational. This paper investigates the socio-technical factors influencing the success and failure of these projects, focusing on outcomes and processes integral to community MHPPs. The study analyses the critical implications of MHPPs for socio-economic welfare, gender equity and democratic governance through extensive primary research including field observations at 40 sites, questionnaire surveys with community residents in three in-depth case-studies, and expert interviews with local policymakers and project developers. Analysis shows that electricity provision from MHPPs has had positive outcomes for the communities in terms of improved education, poverty alleviation and economic growth, alongside enhanced access to information and gains in women’s entrepreneurship and health. Nonetheless, the study also identifies significant shortcomings in the processes involved in community MHPPs related to inadequate technical assessments, monitoring, and evaluation, as well as challenges arising from undemocratic governance mechanisms and inequitable participation. By teasing out the multiple socio-technical dimensions that shape infrastructure resilience of MHPPs in KPK, this paper contributes to the broader discourse on sustainable community energy projects and informs policy for decentralised energy transitions that ensure democratic alignment and inclusive design.

The present study concentrates on the motion of a third-grade fluid with magneto-hydrodynamics (MHD) over a stretching surface. Additionally, the Cattaneo–Christov model is employed to derive information about the heat flux, which is subsequently utilized to ascertain the heat transmission properties. The inquiry involves an assessment of the impact of thermal relaxation time on the boundary layer. The considered fluid is a type of non-Newtonian fluid that deal with both shear thinning and shear thickening behaviors. The study also involved calculating all normal stress components that are not accounted for by either the power law model or the second grade model. The motion of fluid is attributed by linear stretching, and the momentum flow is observed with the help of Soret–Dufour effects. The Cattaneo and Christov model is particularly beneficial for describing transmission of heat in materials with high thermal conductivity, where the classical Fourier’s law may not be accurate. The examination of the transport properties of velocity, heat, and mass involves the consideration of the temperature effect on variable viscosity and thermal conductivity, which are linearly associated with each other. A set of partial differential equations (PDEs) that are nonlinear in nature has been derived, and some boundary conditions have been identified that yield satisfactory results. Using similarity transformation a system of nonlinear PDE’s are modify into dimensionless system of ordinary differential equations (ODE’s). The homotopy analysis method (HAM) is applied in a convenient manner to obtain solutions for transform equations, while the impact of relevant flow parameters is visually demonstrated. Adequate graphical and tabular results are achieved using a semi-analytical approach. Moreover, the Cattaneo–Christov equation can provide a better understanding of the thermal behavior. It allows for a more comprehensive analysis of the thermal response, ensuring that the heat transfer models used are appropriate for such conditions.

Introduction: Ventricular remodeling is a mal-adaptive process. Both angiotensin-converting enzyme inhibitors and sacubitril/valsartan have been shown to reverse remodeling in mostly uncontrolled observational studies. There is a lack of head-to-head studies. Methods: This cohort study compares the remodeling effects of angiotensin receptor blockers combined with a neprilysin inhibitor (ARNI) and perindopril in heart failure with reduced ejection fraction (HFrEF) patients between January 2017 and December 2020. Inclusion criteria: (i) age > 18 years, (ii) recent diagnosis of de-novo HFrEF (EF

Penelitian ini bertujuan mengevaluasi keberhasilan penggunaan metode tutor sebaya untuk peserta didik pada materi penjumlahan dan pengurangan pecahan campuran di SDN Bungkus Kretek Bantul. Metode tutor sebaya adalah suatu pendekatan di mana peserta didik yang memiliki pemahaman yang baik dalam suatu materi membantu peserta didik lain dalam memahami materi tersebut. Penelitian dilakukan dengan menggunakan desain eksperimen kuasi. Sampel penelitian ini terdiri dari dua kelas di SDN Bungkus Kretek Bantul, yaitu kelas eksperimen yang menerapkan metode tutor sebaya dan kelas kontrol yang menerapkan metode pengajaran konvensional. Data dikumpulkan melalui tes prestasi belajar yang meliputi soal-soal penjumlahan dan pengurangan pecahan campuran sebelum dan setelah intervensi. Hasil penelitian menunjukkan bahwa terdapat peningkatan prestasi belajar yang signifikan pada kelompok peserta didik yang mendapatkan metode tutor sebaya. Skor rata-rata prestasi belajar pada kelompok eksperimen meningkat secara signifikan setelah intervensi metode tutor sebaya. Sedangkan pada kelompok kontrol, peningkatan prestasi belajar tidak signifikan setelah intervensi metode pengajaran konvensional. Penelitian ini menunjukkan metode tutor sebaya efektif dalam meningkatkan prestasi belajar penjumlahan dan pengurangan pecahan campuran. Metode ini memberikan kesempatan kepada peserta didik untuk belajar secara kolaboratif, saling membantu, dan saling membangun pemahaman. Oleh karena itu, disarankan bagi guru dan sekolah untuk mempertimbangkan penggunaan metode tutor sebaya dalam mengajar materi-materi yang sulit dipahami oleh sebagian peserta didik, seperti penjumlahan dan pengurangan pecahan campuran.

The basic Helix-Loop-Helix (bHLH) superfamily is the most widespread family of transcription factors in eukaryotic organisms, which can activate the expression of genes by interacting with specific promoters in the genes. The bHLH transcription factors direct the development and metabolic process of plants, including flowering initiation and secondary metabolite production, by attaching to specific sites on their promoters. These transcription factors are essential for encouraging plant tolerance or the adjustment to harsh environmental conditions. The involvement of bHLH genes in anthocyanin formation in fleshy fruit-bearing plants, as well as the role of these genes in response to stimuli including drought, salt, and cold stress, are discussed in this article. New concepts and goals for the production of stress-tolerant fruit species are suggested. Furthermore, solid evidence for the critical role of bHLH genes in the growth and development, as well as anthocyanin biosynthesis in fleshy fruit plants, are also presented in this article. This review identifies several future research directions that can shed light on the roles of bHLH genes in fruit-bearing plants and will assist the use of these genes in efforts to breed fruit crop varieties that are more resistant to stress. Generally, there has been little research carried out on the role of bHLHs transcription factor family genes in fleshy fruit-bearing plant species and more in-depth studies are required to fully understand the diverse role of bHLH genes in these species.

It is a well-known fact that inclusion and pseudo-order relations are two different concepts which are defined on the interval spaces, and we can define different types of convexities with the help of both relations. By means of pseudo-order relation, the present article deals with the new notions of convex functions which are known as left and right log-ss-convex interval-valued functions (IVFs) in the second sense. The main motivation of this study is to present new inequalities for left and right log-ss-convex-IVFs. Therefore, we establish some new Jensen-type, Hermite-Hadamard (HH)-type, and Hermite-Hadamard-Fejér (HH-Fejér)-type inequalities for this kind of IVF, which generalize some known results. To strengthen our main results, we provide nontrivial examples of left and right log-ss-convex IVFs.

IntroductionIntellectual disability (ID) is a clinically and genetically heterogeneous disorder. It drastically affects the learning capabilities of patients and eventually reduces their IQ level below 70.MethodsThe current genetic study ascertained two consanguineous Pakistani families suffering from autosomal recessive intellectual developmental disorder-5 (MRT5). We have used exome sequencing followed by Sanger sequencing to identify the disease-causing variants.Results and discussionGenetic analysis using whole exome sequencing in these families identified two novel mutations in the NSUN2 (NM_017755.5). Family-A segregated a novel missense variant c.953A>C; p.Tyr318Ser in exon-9 of the NSUN2. The variant substituted an amino acid Tyr318, highly conserved among different animal species and located in the functional domain of NSUN2 known as “SAM-dependent methyltransferase RsmB/NOP2-type”. Whereas in family B, we identified a novel splice site variant c.97-1G>C that affects the splice acceptor site of NSUN2. The identified splice variant (c.97-1G>C) was predicted to result in the skipping of exon-2, which would lead to a frameshift followed by a premature stop codon (p. His86Profs*16). Furthermore, it could result in the termination of translation and synthesis of dysfunctional protein, most likely leading to nonsense-mediated decay. The dynamic consequences of NSUN2 missense variant was further explored together with wildtype through molecular dynamic simulations, which uncovered the disruption of NSUN2 function due to a gain in structural flexibility. The present molecular genetic study further extends the mutational spectrum of NSUN2 to be involved in ID and its genetic heterogeneity in the Pakistani population.

The Ziziphus mauritiana Lam. and Z. jujuba Mill. are the two most economically important members of the genus Ziziphus. The fruit color of Z. mauritiana remains green throughout fruit development in the majority of commercial cultivars, whereas its close relative, Z. jujuba Mill. turns from green to red in all cultivars. However, the lack of transcriptomic and genomic information confines our understanding of the molecular mechanisms underlying fruit coloration in Z. mauritiana (Ber). In the present study, we performed the transcriptome-wide analysis of MYB transcription factors (TFs) genes in Z. mauritiana and Z. jujuba, and identified 56 ZmMYB and 60 ZjMYB TFs in Z. mauritiana and Z. jujuba, respectively. Through transcriptomic expression analysis, four similar MYB genes (ZmMYB/ZjMYB13, ZmMYB/ZjMYB44, ZmMYB/ZjMYB50, and ZmMYB/ZjMYB56) from Z. mauritiana and Z. jujuba were selected as candidate key genes regulating flavonoid biosynthesis. Among these genes, the ZjMYB44 gene was transiently highly expressed in fruit, and flavonoid content accumulation also increased, indicating that this gene can influence flavonoid content during the period of fruit coloration in Z. jujuba. The current study adds to our understanding of the classification of genes, motif structure, and predicted functions of the MYB TFs, as well as identifying MYBs that regulate flavonoid biosynthesis in Ziziphus (Z. mauritiana and Z. jujuba). Based on this information, we concluded that MYB44 is involved in the flavonoids biosynthesis pathway during the fruit coloring of Ziziphus. Our research results provide an important understanding of the molecular mechanism of flavonoid biosynthesis resulting in fruit coloration and laying a foundation for further genetic improvement of fruit color in Ziziphus.

Abstract Ziziphus fruits have attracted much attention within the field of medicine due to their high potential against central nervous system disorders. Abundance of secondary metabolites and their composition is key to the pharmaceutical potential and commercial qualities of plants. The in vitro antioxidant activities of Ziziphus nummularia (Burm. f.) and Ziziphus oxyphylla Edgew fruit extract were analyzed using 2,2‐diphenil‐1‐pycrilhydrazyl (DPPH) and 2,2′‐azino‐bis (3‐ethylbenzothiazoline)‐6‐sulfonic acid (ABTS) free radical scavenging assay methods. Phenolic profiles were explored using high‐performance liquid chromatography‐diode array detector (HPLC‐DAD). The result revealed high concentration of polyphenols and their antioxidant potential. In Z. nummularia, the total phenolic content (TPC) (80.270 ± 0.422 μg/ml), DPPH (62.03 ± 0.98 μg/ml), ABTS (66.32 ± 0.73 μg/ml), and TFC (90.683 ± 0.274 μg/ml) were recorded. However, in Z. oxyphylla, DPPH and ABTS values were 60.66 ± 0.56 μg/ml and 61.55 ± 0.77 μg/ml, respectively, indicative of the impacts of climate and soil nutrients. The overall screening of phytochemicals revealed that both the Ziziphus species contain diverse bioactive compounds, including spinacetine‐3‐O‐(2 feruloyl glucopyranosyl)‐glucopyranoside, kaempferol‐3‐O‐glucoside‐7‐O‐glucoside, and caffeic acid; p‐hydroxybenzoyl hexose, p‐coumaric acid, salicylic acid, and ellagic acid pentoxide. Additionally, the highest concentrated amino acid noted was of Lue 0.19 g/100 g with 596.00 retention time (RT), followed by Thr>Ale>Isl>Phya>Val in Z. nummularia. Similarly, the highest concentration of Lue amino acid was recorded as 0.18/100 g with 564.52 RT followed by Pr>Thr>Ale>Lue>Isl>Phya>Val in all genotypes of Z. oxyphylla. Reporting of polyphenols rich and stable species along with identification of favorable regions of cultivation for amino acid, polyphenols, and higher antioxidant potential may lead the way for the identification of elite clones of the species as well as may result in new drug discovery.

Cinnamomum balansae Lecomte (Lauraceae), an economically important forest tree, is distributed in the tropical forests of central and northern Vietnam, which has been threatened in recent decades due to the destruction of its habitat and over-exploitation. The genetic diversity and population structure of the species have not been fully evaluated. We used a set of 15 microsatellites to analyze 161 adult trees from 9 different populations, representing the geographical distribution of C. balansae. Ninety-two different alleles were identified. Here our results showed a low genetic diversity level with an average H o = 0.246 and H e = 0.262, and a high level of genetic differentiation (F ST = 0.601). The bottleneck tests indicated evidence of a reduction in the population size of the two populations (TC and CP). Additionally, all three clustering methods (Bayesian analysis, principal coordinate analysis, and Neighbor-joining tree) were identified in the two genetic groups. The Mantel test showed a significant positive correlation between genetic distance and geographic distance (R 2 = 0.7331). This study will provide a platform for the conservation of C. balansae both in ex-situ and in-situ plans.

The World Health Organization (WHO) acknowledges that the absence of a common definition of the private health sector may hinder a comprehensive understanding of its ubiquity. (1) Physicians, nurses, pharmacists, [...]

To study the difference among cytoplasm at the different nitrogen conditions, a research experiment was conducted using five different cytoplasmic male sterile (CMS) hybrid rice with nitrogen levels at N0, N1, N2, and N3; the nitrogen application rates were 0, 90, 180, and 270 kg/ha, from 2018 to 2019. Results showed that among tested cultivars of CMS hybrid rice, JW (J803A × Chenghui727) showed the highest yield in both years for the low nitrogen and high nitrogen treatments. The dry matter accumulation and translation of JW type in nutritive organs were higher than that of others during the low nitrogen level (N1). We concluded that the nutrient translocation within plants organs and dry biomass accumulation were highly dependent on CMS type and nitrogen application. This research indicates that selecting a rice cultivar with greater efficiency of nitrogen is favourable for raising the number of grains per panicle, grain yield, and nitrogen use efficiency. JW cytoplasm displayed great efficiency in low nitrogen, which is a potential cytoplasmic resource.